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Reinhard Schliebs

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Francisco J Gil-Bea; Ludmil P Kirazov; Barbara Aisa; Gorka Gerenu; Reinhard Schliebs; María J Ramírez
Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.
F Kara; Reinhard Schliebs; M A van Buchem; E S van Dongen; H J M de Groot; A Alia
Monitoring blood flow alterations in the Tg2576 mouse model of Alzheimer's disease by in vivo magnetic resonance angiography at 17.6 T.
Reinhard Schliebs; Thomas Arendt
The cholinergic system in aging and neuronal degeneration.

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2012: Francisco J Gil-Bea; Ludmil P Kirazov; Barbara Aisa; Gorka Gerenu; Reinhard Schliebs; María J Ramírez
Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.
Neurobiology of disease 2012;48(3):439-46.
2012: F Kara; Reinhard Schliebs; M A van Buchem; E S van Dongen; H J M de Groot; A Alia
Monitoring blood flow alterations in the Tg2576 mouse model of Alzheimer's disease by in vivo magnetic resonance angiography at 17.6 T.
NeuroImage 2012;60(2):958-66.
2011: Reinhard Schliebs; Thomas Arendt
The cholinergic system in aging and neuronal degeneration.
Behavioural brain research 2011;221(2):555-63.
2011: Maike Hartlage-Rübsamen; Carsten Jäger; Birgit Koch; Markus Morawski; Stephan Schilling; Reinhard Schliebs; Alexander Waniek; Ulrike Zeitschel; Holger Cynis; Hans-Ulrich Demuth; Steffen Rossner
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.
Acta neuropathologica 2011;121(6):705-19.
2011: Cheryl A Hawkes; Wolfgang Härtig; Johannes Kacza; Reinhard Schliebs; Roy O Weller; Nicoll James; Roxana O Carare
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy.
Acta neuropathologica 2011;121(4):431-43.
2010: Susanne Bürger; Yousef Yafai; Marina Bigl; Peter Wiedemann; Reinhard Schliebs
Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the β-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2010;28(7):597-604.
2010: Markus Morawski; Sanja Pavlica; Gudrun Seeger; Jens Grosche; Elena Kouznetsova; Reinhard Schliebs; Gert Brückner; Thomas Arendt
Perineuronal nets are largely unaffected in Alzheimer model Tg2576 mice.
Neurobiology of aging 2010;31(7):1254-6.
2010: Sandra Ebert; Miriam Goos; Lena Rollwagen; Daniel Baake; Wolf-Dieter Zech; Hermann Esselmann; Jens Wiltfang; Brit Mollenhauer; Reinhard Schliebs; Joachim Gerber; Roland Nau
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.
Journal of neuroscience research 2010;88(5):1124-36.
2010: Cornelius K Donat; Bernd Walter; Tanja Kayser; Winnie Deuther-Conrad; Reinhard Schliebs; Karen Nieber; Reinhard Bauer; Wolfgang Härtig; Peter Brust
Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2010;28(1):31-8.
2010: Amadi O Ihunwo; Reinhard Schliebs
Cell proliferation and total granule cell number in dentate gyrus of transgenic Tg2576 mouse.
Acta neurobiologiae experimentalis 2010;70(4):362-9.
2010: Konstanze Plaschke; Juergen Kopitz; Markus Siegelin; Reinhard Schliebs; Melita Salkovic-Petrisic; Peter Riederer; Siegfried Hoyer
Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice.
Journal of Alzheimer's disease : JAD 2010;19(2):691-704.
2009: Gordana Glavan; Reinhard Schliebs; Marko Zivin
Synaptotagmins in neurodegeneration.
Anatomical record (Hoboken, N.J. : 2007) 2009;292(12):1849-62.
2009: Susanne Bürger; Monika Noack; Ludmil Kirazov; Evgeni P Kirazov; Cyrill L Naydenov; Elena Kouznetsova; Yousef Yafai; Reinhard Schliebs
Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(6):517-23.
2009: M C Rivera-Cervantes; M E Flores-Soto; V Chaparro-Huerta; J Reyes-Gómez; A Feria-Velasco; Reinhard Schliebs; C Beas-Zárate
Changes in hippocampal NMDA-R subunit composition induced by exposure of neonatal rats to L-glutamate.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(2):197-204.
2009: Sabine Augustin; Gerald Rimbach; Kay Augustin; Reinhard Schliebs; Siegfried Wolffram; Rainer Cermak
Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease.
Archives of biochemistry and biophysics 2009;481(2):177-82.
2009: Thomas Walther; Doris Albrecht; Matthias Becker; Manja Schubert; Elena Kouznetsova; Burkard Wiesner; Björn Maul; Reinhard Schliebs; Gisela Grecksch; Jens Furkert; Anja Sterner-Kock; Heinz-Peter Schultheiss; Axel Becker; Wolf-Eberhard Siems
Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.
PloS one 2009;4(2):e4590.
2009: Dietlind Sorger; Matthias Scheunemann; Johnny Vercouillie; Udo Grossmann; Steffen Fischer; Achim Hiller; Barbara Wenzel; Ali Roghani; Reinhard Schliebs; Jörg Steinbach; Peter Brust; Osama Sabri
Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines.
Nuclear medicine and biology 2009;36(1):17-27.
2008: Katrin Bigl; Frank Gaunitz; Annett Schmitt; Sven Rothemund; Reinhard Schliebs; Gerald Münch; Thomas Arendt
Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(11):1545-56.
2008: Michael Baier; Jenny Apelt; Constanze Riemer; Sandra Gültner; Anja Schwarz; Theresa Bamme; Michael Burwinkel; Reinhard Schliebs
Prion infection of mice transgenic for human APPSwe: increased accumulation of cortical formic acid extractable Abeta(1-42) and rapid scrapie disease development.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2008;26(7):821-4.
2008: Anna Fiedorowicz; Izabela Figiel; Małgorzata Zaremba; Karolina Dzwonek; Reinhard Schliebs; Barbara Oderfeld-Nowak
Trimethyltin-evoked apoptosis of murine hippocampal granule neurons is accompanied by the expression of interleukin-1beta and interleukin-1 receptor antagonist in cells of ameboid phenotype, the majority of which are NG2-positive.
Brain research bulletin 2008;77(1):19-26.
2008: Philipp Herrmann; Caroline Druckrey-Fiskaaen; Elena Kouznetsova; Katrin Heinitz; Marina Bigl; Susan L Cotman; Reinhard Schliebs
Developmental impairments of select neurotransmitter systems in brains of Cln3(Deltaex7/8) knock-in mice, an animal model of juvenile neuronal ceroid lipofuscinosis.
Journal of neuroscience research 2008;86(8):1857-70.
2008: Sabrina Joerchel; Maik Raap; Marina Bigl; Klaus Eschrich; Reinhard Schliebs
Oligomeric beta-amyloid(1-42) induces the expression of Alzheimer disease-relevant proteins in cholinergic SN56.B5.G4 cells as revealed by proteomic analysis.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2008;26(3-4):301-8.
2008: Dietlind Sorger; Matthias Scheunemann; Udo Grossmann; Steffen Fischer; Johnny Vercouille; Achim Hiller; Barbara Wenzel; Ali Roghani; Reinhard Schliebs; Peter Brust; Osama Sabri; Jörg Steinbach
A new 18F-labeled fluoroacetylmorpholino derivative of vesamicol for neuroimaging of the vesicular acetylcholine transporter.
Nuclear medicine and biology 2008;35(2):185-95.
2008: Sabine Augustin; Patricia Huebbe; Nicole Matzner; Kay Augustin; Reinhard Schliebs; Rainer Cermak; Siegfried Wolffram; Gerald Rimbach
Ginkgo biloba extract and its flavonol and terpenelactone fractions do not affect beta-secretase mRNA and enzyme activity levels in cultured neurons and in mice.
Planta medica 2008;74(1):6-13.
2007: Cornelius Kurt Donat; Martin U Schuhmann; Cornelia Voigt; Karen Nieber; Reinhard Schliebs; Peter Brust
Alterations of acetylcholinesterase activity after traumatic brain injury in rats.
Brain injury : [BI] 2007;21(10):1031-7.
2007: Seong-Wook Yun; Elena Kouznetsova; Cindy Nitschke; Katrin Heinitz; Reinhard Schliebs; Manfred Gerlach; Peter Riederer; Michael A Klein
beta-Amyloid deposition and prion infection in adult primary brain cell long-term culture model.
Biochemical and biophysical research communications 2007;360(3):520-4.
2007: Francisco J Gil-Bea; Bárbara Aisa; Reinhard Schliebs; María J Ramírez
Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice.
Behavioral neuroscience 2007;121(2):340-4.
2007: Dietlind Sorger; Georg A Becker; Marianne Patt; Andreas Schildan; Udo Grossmann; Reinhard Schliebs; Anita Seese; Kai Kendziorra; Magnus Kluge; Peter Brust; Alexey G Mukhin; Osama Sabri
Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study.
Nuclear medicine and biology 2007;34(3):331-42.
2006: Reinhard Schliebs; Kristin Heidel; Jenny Apelt; Magdalena Gniezdzinska; Ludmil Kirazov; Andrzej Szutowicz
Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Brain research 2006;1122(1):78-85.
2006: Reinhard Schliebs; Thomas Arendt
The significance of the cholinergic system in the brain during aging and in Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(11):1625-44.
2006: Tobias Stahl; Christine Reimers; Reimar Johne; Reinhard Schliebs; Johannes Seeger
Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.
The European journal of neuroscience 2006;24(7):1923-34.
2006: Dietlind Sorger; Georg A Becker; Katharina Hauber; Andreas Schildan; Marianne Patt; Gerd Birkenmeier; Andreas Otto; Philipp Meyer; Magnus Kluge; Reinhard Schliebs; Osama Sabri
Binding properties of the cerebral alpha4beta2 nicotinic acetylcholine receptor ligand 2-[18F]fluoro-A-85380 to plasma proteins.
Nuclear medicine and biology 2006;33(7):899-906.
2006: ME Flores-Soto; J Bañuelos-Pineda; Sandra Orozco-Suárez; Reinhard Schliebs; Carlos Beas-Zárate
Neuronal damage and changes in the expression of muscarinic acetylcholine receptor subtypes in the neonatal rat cerebral cortical upon exposure to sparteine, a quinolizidine alkaloid.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(6):401-10.
2006: Katrin Heinitz; Martin Beck; Reinhard Schliebs; J Regino Perez-Polo
Toxicity mediated by soluble oligomers of beta-amyloid(1-42) on cholinergic SN56.B5.G4 cells.
Journal of neurochemistry 2006;98(6):1930-45.
2006: Niels Braakman; Jörg Matysik; Sjoerd G van Duinen; Fons Verbeek; Reinhard Schliebs; Huub J M de Groot; A Alia
Longitudinal assessment of Alzheimer's beta-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging.
Journal of magnetic resonance imaging : JMRI 2006;24(3):530-6.
2006: Elena Kouznetsova; Margrit Klingner; Dietlind Sorger; Osama Sabri; Udo Grossmann; Jörg Steinbach; Matthias Scheunemann; Reinhard Schliebs
Developmental and amyloid plaque-related changes in cerebral cortical capillaries in transgenic Tg2576 Alzheimer mice.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(2-3):187-93.
2006: Wolfgang Liskowsky; Reinhard Schliebs
Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(2-3):149-56.
2006: Thole Zuchner; N Schliebe; Reinhard Schliebs
Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(1):23-7.
2005: Barbara Wenzel; Dietlind Sorger; Katrin Heinitz; Matthias Scheunemann; Reinhard Schliebs; Jörg Steinbach; Osama Sabri
Structural changes of benzylether derivatives of vesamicol and their influence on the binding selectivity to the vesicular acetylcholine transporter.
European journal of medicinal chemistry 2005;40(12):1197-205.
2005: Thole Zuchner; Reinhard Schliebs; J Regino Perez-Polo
Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins.
Journal of neurochemistry 2005;95(1):20-32.
2005: Reinhard Schliebs
Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling.
Neurochemical research 2005;30(6-7):895-908.
2005: Steffen Rossner; Ingo Schulz; Ulrike Zeitschel; Reinhard Schliebs; Volker Bigl; Hans-Ulrich Demuth
Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease.
Neurochemical research 2005;30(6-7):695-702.
2005: Ludmil Kirazov; E Kirazovi; Reinhard Schliebs
L-glutamate and phorbol ester stimulate the release of secretory amyloid precursor protein from rat cortical synaptosomes.
Acta biologica Hungarica 2005;56(3-4):177-83.
2004: Jenny Apelt; Marina Bigl; Patrick Wunderlich; Reinhard Schliebs
Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(7):475-84.
2004: Reinhard Schliebs
Molecular mechanisms of neurodegeneration and neuroprotection--experimental approaches and the diseased brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(7):441-2.
2004: Thole Züchner; J Regino Perez-Polo; Reinhard Schliebs
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling.
Journal of neuroscience research 2004;77(2):250-7.
2004: Imrich Blasko; R Beer; Marina Bigl; Jenny Apelt; Gerhard Franz; D Rudzki; Gerhard Ransmayr; Andreas Kampfl; Reinhard Schliebs
Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(4):523-36.
2004: Matthias Scheunemann; Dietlind Sorger; Barbara Wenzel; Katrin Heinitz; Reinhard Schliebs; Margrit Klingner; Osama Sabri; Jörg Steinbach
Synthesis of novel 4- and 5-substituted benzyl ether derivatives of vesamicol and in vitro evaluation of their binding properties to the vesicular acetylcholine transporter site.
Bioorganic & medicinal chemistry 2004;12(6):1459-65.
2003: Margrit Klingner; Jenny Apelt; Ashok Kumar; Dietlind Sorger; Osama Sabri; Jörg Steinbach; Matthias Scheunemann; Reinhard Schliebs
Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(7):357-69.
2003: Maria Tomaszewicz; Steffen Rossner; Reinhard Schliebs; Justyna Cwikowska; Andrzej Szutowicz
Changes in cortical acetyl-CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG-saporin.
Journal of neurochemistry 2003;87(2):318-24.
2003: Hans-Joachim Lüth; Jenny Apelt; Amadi O Ihunwo; Thomas Arendt; Reinhard Schliebs
Degeneration of beta-amyloid-associated cholinergic structures in transgenic APP SW mice.
Brain research 2003;977(1):16-22.
2003: Gerald Münch; Jenny Apelt; Peter Stahl; Hans-Joachim Lüth; Reinhard Schliebs
Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology.
Journal of neurochemistry 2003;86(2):283-9.
2003: Jenny Apelt; Katrin Ach; Reinhard Schliebs
Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques.
Neuroscience letters 2003;339(3):183-6.
2003: Maike Hartlage-Rübsamen; Ulrike Zeitschel; Jenny Apelt; Ulrich Gärtner; Heike Franke; Tobias Stahl; Albrecht Günther; Reinhard Schliebs; Milena Penkowa; Volker Bigl; Steffen Rossner
Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.
Glia 2003;41(2):169-79.
2003: Marina Bigl; Jenny Apelt; Klaus Eschrich; Reinhard Schliebs
Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(1):77-94.
2002: Jenny Apelt; Ashok Kumar; Reinhard Schliebs
Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein.
Brain research 2002;953(1-2):17-30.
2002: CAROLA OTTH; Ilona I Concha; Thomas Arendt; Jens Stieler; Reinhard Schliebs; Christian Gonzalez-Billault; Ricardo B Maccioni
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.
Journal of Alzheimer's disease : JAD 2002;4(5):417-30.
2002: Ulrike Zeitschel; Reinhard Schliebs; Steffen Rossner; Volker Bigl; Klaus Eschrich; Marina Bigl
Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion.
Journal of neurochemistry 2002;83(2):371-80.
2002: EA Lushchekina; Marina Bigl; Jenny Apelt; Christine Lange-Dohna; Steffen Rossner; Reinhard Schliebs
Expression of beta-Secretase mRNA in the brain of rats with immunohistochemical destruction of basal forebrain cholinergic system.
Bulletin of experimental biology and medicine 2002;134(3):236-40.
2002: Jenny Apelt; Jacqueline Lessig; Reinhard Schliebs
Beta-amyloid-associated expression of intercellular adhesion molecule-1 in brain cortical tissue of transgenic Tg2576 mice.
Neuroscience letters 2002;329(1):111-5.
2002: Wolfgang Härtig; Andreas Bauer; Kurt Brauer; Jens Grosche; Tibor Hortobágyi; Botond Penke; Reinhard Schliebs; Tibor Harkany
Functional recovery of cholinergic basal forebrain neurons under disease conditions: old problems, new solutions?
Reviews in the neurosciences 2002;13(2):95-165.
2001: Steffen Rossner; Jenny Apelt; Reinhard Schliebs; J Regino Perez-Polo; Volker Bigl
Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.
Journal of neuroscience research 2001;64(5):437-46.
2001: E Kirazov; Ludmil Kirazov; Volker Bigl; Reinhard Schliebs
Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2001;19(3):287-96.
2001: Thorsten Löffler; Samiya Al-Robaiy; Marina Bigl; Klaus Eschrich; Reinhard Schliebs
Expression of fructose-1,6-bisphosphatase mRNA isoforms in normal and basal forebrain cholinergic lesioned rat brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2001;19(3):279-85.
2001: Reinhard Schliebs
Neuronal plasticity and degeneration.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2001;19(3):229-30.
2001: Maike Hartlage-Rübsamen; Jenny Apelt; Reinhard Schliebs
Fibrillary beta-amyloid deposits are closely associated with atrophic nitric oxide synthase (NOS)-expressing neurons but do not upregulate the inducible NOS in transgenic Tg2576 mouse brain with Alzheimer pathology.
Neuroscience letters 2001;302(2-3):73-6.
2001: Maike Hartlage-Rübsamen; Reinhard Schliebs
Sequential upregulation of cell adhesion molecules in degenerating rat basal forebrain cholinergic neurons and in phagocytotic microglial cells.
Brain research 2001;897(1-2):20-6.
2001: Steffen Rossner; Klaus Mendla; Reinhard Schliebs; Volker Bigl
Protein kinase Calpha and beta1 isoforms are regulators of alpha-secretory proteolytic processing of amyloid precursor protein in vivo.
The European journal of neuroscience 2001;13(8):1644-8.
2001: Jenny Apelt; Reinhard Schliebs
Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology.
Brain research 2001;894(1):21-30.
2001: Maike Hartlage-Rübsamen; Reinhard Schliebs
Rat basal forebrain cholinergic lesion affects neuronal nitric oxide synthase activity in hippocampal and neocortical target regions.
Brain research 2001;889(1-2):155-64.
2001: Thorsten Löffler; S K Lee; Michael Nöldner; Shyam Chatterjee; Siegfried Hoyer; Reinhard Schliebs
Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain.
Journal of neural transmission (Vienna, Austria : 1996) 2001;108(12):1457-74.
2001: Steffen Rossner; G Mehlhorn; Reinhard Schliebs; Volker Bigl
Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology.
The European journal of neuroscience 2001;13(2):269-78.
2000: Marina Bigl; Jenny Apelt; E A Luschekina; Christine Lange-Dohna; Steffen Rossner; Reinhard Schliebs
Expression of beta-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology.
Neuroscience letters 2000;292(2):107-10.
2000: Steffen Rossner; M Beck; Tobias Stahl; Klaus Mendla; Reinhard Schliebs; Volker Bigl
Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation.
The European journal of neuroscience 2000;12(9):3191-200.
2000: G Mehlhorn; Margrit Hollborn; Reinhard Schliebs
Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2000;18(4-5):423-31.
2000: Steffen Rossner; Reinhard Schliebs; Volker Bigl
Intracerebroventricular infusion of CHO5, a rat monoclonal antibody directed against mouse low-affinity nerve growth factor receptor (p75NTR), specifically labels basal forebrain cholinergic neurons in mouse brain.
Metabolic brain disease 2000;15(1):17-27.
2000: Siegfried Hoyer; S K Lee; Thorsten Löffler; Reinhard Schliebs
Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
Annals of the New York Academy of Sciences 2000;920():256-8.
2000: Dietlind Sorger; Reinhard Schliebs; I Kämpfer; Steffen Rossner; J Heinicke; Claudia Dannenberg; P Georgi
In vivo [125I]-iodobenzovesamicol binding reflects cortical cholinergic deficiency induced by specific immunolesion of rat basal forebrain cholinergic system.
Nuclear medicine and biology 2000;27(1):23-31.
1999: E Reisner; Michael Nöldner; Steffen Rossner; Shyam Chatterjee; Volker Bigl; Reinhard Schliebs
Acute effect of KA-672, a putative cognitive enhancer, on neurotransmitter receptor binding in mouse brain.
Neuroscience letters 1999;274(3):187-90.
1999: Jenny Apelt; G Mehlhorn; Reinhard Schliebs
Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain.
Journal of neuroscience research 1999;57(5):693-705.
1999: Steffen Rossner; Uwe Ueberham; Reinhard Schliebs; J Regino Perez-Polo; Volker Bigl
Regulated secretion of amyloid precursor protein by TrkA receptor stimulation in rat pheochromocytoma-12 cells is mitogen activated protein kinase sensitive.
Neuroscience letters 1999;271(2):97-100.
1999: Maike Hartlage-Rübsamen; R Lemke; Reinhard Schliebs
Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection.
Journal of neuroscience research 1999;57(3):388-98.
1999: R Lemke; Maike Hartlage-Rübsamen; Reinhard Schliebs
Differential injury-dependent glial expression of interleukins-1 alpha, beta, and interleukin-6 in rat brain.
Glia 1999;27(1):75-87.
1999: R Lemke; Steffen Rossner; Reinhard Schliebs
Leukemia inhibitory factor expression is not induced in activated microglia and reactive astrocytes in response to rat basal forebrain cholinergic lesion.
Neuroscience letters 1999;267(1):53-6.
1999: Dietlind Sorger; I Kämpfer; Reinhard Schliebs; Steffen Rossner; Claudia Dannenberg; WH Knapp
Iodo-QNB cortical binding and brain perfusion: effects of a cholinergic basal forebrain lesion in the rat.
Nuclear medicine and biology 1999;26(1):9-16.
1998: Steffen Rossner; Uwe Ueberham; Reinhard Schliebs; J Regino Perez-Polo; Volker Bigl
The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling.
Progress in neurobiology 1998;56(5):541-69.
1998: Tobias Stahl; Axel Goldammer; E Luschekina; M Beck; Reinhard Schliebs; Volker Bigl
Long-term basal forebrain cholinergic-rich grafts derived from trisomy 16 mice do not develop beta-amyloid pathology and neurodegeneration but demonstrate neuroinflammatory responses.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(7-8):763-75.
1998: G Mehlhorn; Thorsten Löffler; Jenny Apelt; Steffen Rossner; T Urabe; N Hattori; S Nagamatsu; Volker Bigl; Reinhard Schliebs
Glucose metabolism in cholinoceptive cortical rat brain regions after basal forebrain cholinergic lesion.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(7-8):675-90.
1998: Steffen Rossner; N Bakinde; Ulrike Zeitschel; Reinhard Schliebs; Volker Bigl
Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons?
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(7-8):669-73.
1998: Reinhard Schliebs
Basal forebrain cholinergic dysfunction-experimental approaches and the diseased brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(7-8):591-3.
1998: Kurt Brauer; Gudrun Seeger; Wolfgang Härtig; Steffen Rossner; R Poethke; Johannes Kacza; Reinhard Schliebs; Gert Brückner; Volker Bigl
Electron microscopic evidence for a cholinergic innervation of GABAergic parvalbumin-immunoreactive neurons in the rat medial septum.
Journal of neuroscience research 1998;54(2):248-53.
1998: Steffen Rossner; Uwe Ueberham; Reinhard Schliebs; J Regino Perez-Polo; Volker Bigl
p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells.
Journal of neurochemistry 1998;71(2):757-66.
1998: Roger M Nitsch; Steffen Rossner; C Albrecht; M Mayhaus; Janna Enderich; Reinhard Schliebs; Michael Wegner; Thomas Arendt; Heinz von der Kammer
Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter.
Journal of physiology, Paris 1998;92(3-4):257-64.
1998: R Lemke; Wolfgang Härtig; Steffen Rossner; Volker Bigl; Reinhard Schliebs
Interleukin-6 is not expressed in activated microglia and in reactive astrocytes in response to lesion of rat basal forebrain cholinergic system as demonstrated by combined in situ hybridization and immunocytochemistry.
Journal of neuroscience research 1998;51(2):223-36.
1998: Steffen Rossner; Uwe Ueberham; Reinhard Schliebs; J Regino Perez-Polo; Volker Bigl
Neurotrophin binding to the p75 neurotrophin receptor is necessary but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells.
Journal of neural transmission. Supplementum 1998;54():279-85.
1998: Volker Bigl; Reinhard Schliebs
Simulation of cortical cholinergic deficits--a novel experimental approach to study pathogenetic aspects of Alzheimer's disease.
Journal of neural transmission. Supplementum 1998;54():237-47.
1998: F Engel; Rosemarie Blatz; Reinhard Schliebs; M Palmer; S Bhakdi
Bacterial cytolysin perturbs round window membrane permeability barrier in vivo: possible cause of sensorineural hearing loss in acute otitis media.
Infection and immunity 1998;66(1):343-6.
1997: W Sihver; Peter Günther; Reinhard Schliebs; Volker Bigl
Repeated administration of tacrine to normal rats: effects on cholinergic, glutamatergic, and GABAergic receptor subtypes in rat brain using receptor autoradiography.
Neurochemistry international 1997;31(5):693-703.
1997: Steffen Rossner; Uwe Ueberham; J Yu; Ludmil Kirazov; Reinhard Schliebs; J Regino Perez-Polo; Volker Bigl
In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity.
The European journal of neuroscience 1997;9(10):2125-34.
1997: Steffen Rossner; Gitta Wörtwein; Z Gu; J Yu; Reinhard Schliebs; Volker Bigl; J Regino Perez-Polo
Cholinergic control of nerve growth factor in adult rats: evidence from cortical cholinergic deafferentation and chronic drug treatment.
Journal of neurochemistry 1997;69(3):947-53.
1997: M Heider; Reinhard Schliebs; Steffen Rossner; Volker Bigl
Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals.
Neurochemical research 1997;22(8):957-66.
1997: Steffen Rossner; Reinhard Schliebs; Wolfgang Härtig; J Regino Perez-Polo; Volker Bigl
Selective induction of c-Jun and NGF in reactive astrocytes after cholinergic degenerations in rat basal forebrain.
Neuroreport 1997;8(9-10):2199-202.
1997: R Lemke; RA Gadient; Paul H Patterson; Volker Bigl; Reinhard Schliebs
Leukemia inhibitory factor (LIF) mRNA-expressing neuronal subpopulations in adult rat basal forebrain.
Neuroscience letters 1997;229(1):69-71.
1997: Gudrun Seeger; Wolfgang Härtig; Steffen Rossner; Reinhard Schliebs; Gert Brückner; Volker Bigl; Kurt Brauer
Electron microscopic evidence for microglial phagocytic activity and cholinergic cell death after administration of the immunotoxin 192IgG-saporin in rat.
Journal of neuroscience research 1997;48(5):465-76.
1997: Ludmil Kirazov; Thorsten Löffler; Reinhard Schliebs; Volker Bigl
Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices.
Neurochemistry international 1997;30(6):557-63.
1997: Jenny Apelt; Reinhard Schliebs; M Beck; Steffen Rossner; Volker Bigl
Expression of amyloid precursor protein mRNA isoforms in rat brain is differentially regulated during postnatal maturation and by cholinergic activity.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1997;15(1):95-112.
1997: Reinhard Schliebs; André Liebmann; S K Bhattacharya; Ashok Kumar; S Ghosal; Volker Bigl
Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain.
Neurochemistry international 1997;30(2):181-90.
1996: R Lemke; RA Gadient; Reinhard Schliebs; Volker Bigl; Paul H Patterson
Neuronal expression of leukemia inhibitory factor (LIF) in the rat brain.
Neuroscience letters 1996;215(3):205-8.
1996: Steffen Rossner; J Yu; D Pizzo; K Werrbach-Perez; Reinhard Schliebs; Volker Bigl; J Regino Perez-Polo
Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesion.
Journal of neuroscience research 1996;45(1):40-56.
1996: I Kämpfer; Dietlind Sorger; Reinhard Schliebs; W Kärger; K Günther; K Schulze; WH Knapp
Radioiodination of nicotine with specific activity high enough for mapping nicotinic acetylcholine receptors.
European journal of nuclear medicine 1996;23(2):157-62.
1996: Reinhard Schliebs; Steffen Rossner; Volker Bigl
Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction.
Progress in brain research 1996;109():253-64.
1995: Steffen Rossner; Reinhard Schliebs; Volker Bigl
192IgG-saporin-induced immunotoxic lesions of cholinergic basal forebrain system differentially affect glutamatergic and GABAergic markers in cortical rat brain regions.
Brain research 1995;696(1-2):165-76.
1995: Steffen Rossner; Wolfgang Härtig; Reinhard Schliebs; Gert Brückner; Kurt Brauer; J Regino Perez-Polo; R G Wiley; Volker Bigl
192IgG-saporin immunotoxin-induced loss of cholinergic cells differentially activates microglia in rat basal forebrain nuclei.
Journal of neuroscience research 1995;41(3):335-46.
1995: Steffen Rossner; Reinhard Schliebs; Wolfgang Härtig; Volker Bigl
192IGG-saporin-induced selective lesion of cholinergic basal forebrain system: neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus.
Brain research bulletin 1995;38(4):371-81.
1995: Steffen Rossner; Reinhard Schliebs; J Regino Perez-Polo; R G Wiley; Volker Bigl
Differential changes in cholinergic markers from selected brain regions after specific immunolesion of the rat cholinergic basal forebrain system.
Journal of neuroscience research 1995;40(1):31-43.
1994: Steffen Rossner; Reinhard Schliebs; Volker Bigl
Ibotenic acid lesion of nucleus basalis magnocellularis differentially affects cholinergic, glutamatergic and GABAergic markers in cortical rat brain regions.
Brain research 1994;668(1-2):85-99.
1994: Steffen Rossner; J Regino Perez-Polo; R G Wiley; Reinhard Schliebs; Volker Bigl
Differential expression of immediate early genes in distinct layers of rat cerebral cortex after selective immunolesion of the forebrain cholinergic system.
Journal of neuroscience research 1994;38(3):282-93.
1994: A Kumar; Reinhard Schliebs; Volker Bigl
Postnatal development of NMDA, AMPA, and kainate receptors in individual layers of rat visual cortex and the effect of monocular deprivation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1994;12(1):31-41.
1994: Steffen Rossner; A Kumar; Veit Witzemann; Reinhard Schliebs
Development of laminar expression of the m2 muscarinic cholinergic receptor gene in rat visual cortex and the effect of monocular visual deprivation.
Brain research. Developmental brain research 1994;77(1):55-61.
1994: Reinhard Schliebs; Steffen Rossner; A Kumar; Volker Bigl
Muscarinic acetylcholine receptor subtypes in rat visual cortex--a comparative study using quantitative receptor autoradiography and in situ hybridization.
Indian journal of experimental biology 1994;32(1):25-30.
1994: Reinhard Schliebs; T Feist; Steffen Rossner; Volker Bigl
Receptor function in cortical rat brain regions after lesion of nucleus basalis.
Journal of neural transmission. Supplementum 1994;44():195-208.
1994: Carlos Beas-Zárate; Reinhard Schliebs; D Ortuño-Sahagún; A Morales-Villagrán; Alfredo Feria-Velasco
Effect of systemic monosodium L-glutamate on muscarinic cholinergic receptors in selected rat brain regions during development.
Archives of medical research 1994;25(3):341-6.
1993: A Kumar; Reinhard Schliebs
Postnatal ontogeny of GABAA and benzodiazepine receptors in individual layers of rat visual cortex and the effect of visual deprivation.
Neurochemistry international 1993;23(2):99-106.
1993: Steffen Rossner; A Kumar; Wilfried Kues; Veit Witzemann; Reinhard Schliebs
Differential laminar expression of AMPA receptor genes in the developing rat visual cortex using in situ hybridization histochemistry. Effect of visual deprivation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1993;11(4):411-24.
1993: Steffen Rossner; Wilfried Kues; Veit Witzemann; Reinhard Schliebs
Laminar expression of m1-, m3- and m4-muscarinic cholinergic receptor genes in the developing rat visual cortex using in situ hybridization histochemistry. Effect of monocular visual deprivation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1993;11(3):369-78.
1992: A Kumar; Reinhard Schliebs
Postnatal laminar development of cholinergic receptors, protein kinase C and dihydropyridine-sensitive calcium antagonist binding in rat visual cortex. Effect of visual deprivation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1992;10(6):491-504.
1992: G Guzmán-Godínez; Reinhard Schliebs
Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats.
Neurochemistry international 1992;21(3):447-53.
1991: HH Webster; Douglas D Rasmusson; RW Dykes; Reinhard Schliebs; W Schober; Gert Brückner; D Biesold
Long-term enhancement of evoked potentials in raccoon somatosensory cortex following co-activation of the nucleus basalis of Meynert complex and cutaneous receptors.
Brain research 1991;545(1-2):292-6.
1990: Reinhard Schliebs; M G Stewart
Unilateral decortication affects muscarinic cholinergic receptor binding in rat basal forebrain.
Neurochemistry international 1990;16(1):81-7.
1990: Uwe-Frithjof Haustein; Reinhard Schliebs; Jörg Schaller
Changes in muscarinic acetylcholine receptor binding in skin slices of cholinergic urticaria.
Acta dermato-venereologica 1990;70(3):208-11.
1990: Thomas Rothe; U K Hanisch; K Krohn; Reinhard Schliebs; Wolfgang Härtig; HH Webster; D Biesold
Changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury.
Somatosensory & motor research 1990;7(4):435-46.
1989: Thomas Rothe; Reinhard Schliebs
Laminar distribution of benzodiazepine receptors in visual cortex of adult rat.
General physiology and biophysics 1989;8(4):371-80.
1989: Carlos Beas-Zárate; Reinhard Schliebs; A Morales-Villagran; Alfredo Feria-Velasco
Monosodium L-glutamate-induced convulsions: changes in uptake and release of catecholamines in cerebral cortex and caudate nucleus of adult rats.
Epilepsy research 1989;4(1):20-7.
1989: Reinhard Schliebs; M Zivin; J Steinbach; Thomas Rothe
Changes in cholinergic but not in GABAergic markers in amygdala, piriform cortex, and nucleus basalis of the rat brain following systemic administration of kainic acid.
Journal of neurochemistry 1989;53(1):212-8.
1989: M Aurich; Reinhard Schliebs; M G Stewart; E Rudolph; H D Fischer; Volker Bigl
Adaptive changes in the central noradrenergic system in monocular deprived rats.
Brain research bulletin 1989;22(2):173-80.
1989: C Walch; Reinhard Schliebs
Age-dependent changes in the laminar distribution of cholinergic markers in rat visual cortex.
Neurochemistry international 1989;14(3):337-46.
1989: Reinhard Schliebs; C Walch; M G Stewart
Laminar pattern of cholinergic and adrenergic receptors in rat visual cortex using quantitative receptor autoradiography.
Journal für Hirnforschung 1989;30(3):303-11.
1989: C Walch; Reinhard Schliebs; Volker Bigl
Effect of early visual pattern deprivation on development and laminar distribution of cholinergic markers in rat visual cortex.
EXS 1989;57():295-304.
1988: Reinhard Schliebs; Thomas Rothe
Development of GABAA receptors in the central visual structures of rat brain. Effect of visual pattern deprivation.
General physiology and biophysics 1988;7(3):281-91.
1988: Reinhard Schliebs; C Gödicke
Laminar distribution of noradrenergic markers in rat visual cortex.
Neurochemistry international 1988;13(4):481-6.
1987: Reinhard Schliebs; Thomas Rothe; Volker Bigl
Rat retinal benzodiazepine receptors are controlled by visual cortical mechanisms.
Neurochemistry international 1987;10(2):179-84.
1986: Reinhard Schliebs; E Kullmann; Volker Bigl
Development of glutamate binding sites in the visual structures of the rat brain. Effect of visual pattern deprivation.
Biomedica biochimica acta 1986;45(4):495-506.
1986: Reinhard Schliebs; Thomas Rothe; Volker Bigl
Dark-rearing affects the development of benzodiazepine receptors in the central visual structures of rat brain.
Brain research 1986;389(1-2):179-85.
1985: Reinhard Schliebs; S P Rose; M G Stewart
Effect of passive avoidance training on in vitro protein synthesis in forebrain slices of day-old chicks.
Journal of neurochemistry 1985;44(4):1014-28.
1985: Thomas Rothe; Reinhard Schliebs; Volker Bigl
Benzodiazepine receptors in the visual structures of monocularly deprived rats. Effect of light and dark adaptation.
Brain research 1985;329(1-2):143-50.
1984: Reinhard Schliebs; E Kunert; Volker Bigl
Effect of monocular deprivation on uptake and binding of [3H]glutamate in the visual system of rat brain.
Journal of neurochemistry 1984;43(5):1490-3.
1984: Reinhard Schliebs; Volker Bigl
A simple non-parametric procedure for rapid estimation of Scatchard parameters.
General physiology and biophysics 1984;3(3):271-5.
1984: Reinhard Schliebs; Volker Bigl
Kinetics of the interaction of dihydroalprenolol with beta-adrenergic receptors in rat cerebral cortex.
General physiology and biophysics 1984;3(1):31-46.
1984: Reinhard Schliebs; E Estrada; Thomas Rothe; M Aurich; Volker Bigl
Regional distribution of neurotransmitter receptors in the visual structures of the rat brain.
Biomedica biochimica acta 1984;43(10):1119-25.
1983: Reinhard Schliebs; Thomas Rothe; Volker Bigl
[Measurement of radioligand binding to beta-adrenergic and benzodiazepine receptors in the cerebral cortex of the rat. Comparison of filtration and centrifugation technics].
Biomedica biochimica acta 1983;42(5):537-46.
1982: Reinhard Schliebs; Volker Bigl; D Biesold
Development of muscarinic cholinergic receptor binding in the visual system of monocularly deprived and dark reared rats.
Neurochemical research 1982;7(9):1181-98.
1982: Reinhard Schliebs; R D Burgoyne; Volker Bigl
The effect of visual deprivation on beta-adrenergic receptors in the visual centres of the rat brain.
Journal of neurochemistry 1982;38(4):1038-43.
1980: R D Burgoyne; Reinhard Schliebs; Volker Bigl
The effect of visual deprivation on beta-adrenergic receptors in the visual centres of the rat brain.
Biochemical Society transactions 1980;8(5):623-4.