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D H R Blackwood

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L Sha; D G Watson; David J Porteous; D H R Blackwood; N J Brandon; Steven J Clapcote; M P Kelly; Judith Machell; L MacIntyre; Walter J Muir; Ben S Pickard
Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.
William Hennah; P Thomson; A McQuillin; N Bass; A Loukola; A Anjorin; D H R Blackwood; D Curtis; Ian J Deary; Sarah E Harris; E T Isometsä; J Lawrence; J Lönnqvist; Walter Muir; A Palotie; Timo Partonen; T Paunio; E Pylkkö; M Robinson; P Soronen; K Suominen; J Suvisaari; S Thirumalai; D St Clair; H Gurling; L Peltonen; David J Porteous
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.
Ben S Pickard; A Christoforou; P A Thomson; A Fawkes; K L Evans; S W Morris; David J Porteous; D H R Blackwood; Walter J Muir
Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder.

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All Publications

2012: L Sha; D G Watson; David J Porteous; D H R Blackwood; N J Brandon; Steven J Clapcote; M P Kelly; Judith Machell; L MacIntyre; Walter J Muir; Ben S Pickard
Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.
Molecular psychiatry 2012;17(3):267-79.
2009: William Hennah; P Thomson; A McQuillin; N Bass; A Loukola; A Anjorin; D H R Blackwood; D Curtis; Ian J Deary; Sarah E Harris; E T Isometsä; J Lawrence; J Lönnqvist; Walter Muir; A Palotie; Timo Partonen; T Paunio; E Pylkkö; M Robinson; P Soronen; K Suominen; J Suvisaari; S Thirumalai; D St Clair; H Gurling; L Peltonen; David J Porteous
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.
Molecular psychiatry 2009;14(9):865-73.
2009: Ben S Pickard; A Christoforou; P A Thomson; A Fawkes; K L Evans; S W Morris; David J Porteous; D H R Blackwood; Walter J Muir
Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder.
Molecular psychiatry 2009;14(9):874-84.
2009: H C Whalley; B S Pickard; A M McIntosh; R Zuliani; E C Johnstone; D H R Blackwood; S M Lawrie; W J Muir; J Hall
A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function.
Molecular psychiatry 2009;14(5):467-8.
2009: Heather C Whalley; Ben S Pickard; Andrew M McIntosh; R Zuliani; Eve C Johnstone; D H R Blackwood; Stephen M Lawrie; Walter J Muir; Jeremy Hall
Modulation of hippocampal activation by genetic variation in the GRIK4 gene.
Molecular psychiatry 2009;14(5):465.
2008: Ben S Pickard; H M Knight; R S Hamilton; D C Soares; R Walker; J K F Boyd; Judith Machell; A Maclean; McGhee Kevin; A Condie; David J Porteous; D St Clair; I Davis; D H R Blackwood; Walter J Muir
A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14940-5.
2008: Helen M Knight; Alan Maclean; Muhammad Irfan; Farooq Naeem; Stephen Cass; Benjamin S Pickard; Walter J Muir; D H R Blackwood; Muhammad Ayub
Homozygosity mapping in a family presenting with schizophrenia, epilepsy and hearing impairment.
European journal of human genetics : EJHG 2008;16(6):750-8.
2008: Carl A Anderson; Alan Maclean; Matthew G Dunnigan; Anthony Pelosi; Valerie Murray; I McKee; George McDonald; David W Burt; David R Morrice; Walter J Muir; Peter M Visscher; D H R Blackwood
A genome-wide linkage study in families with major depression and co-morbid unexplained swelling.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147(3):356-62.
2008: Walter J Muir; Benjamin S Pickard; D H R Blackwood
Disrupted-in-Schizophrenia-1.
Current psychiatry reports 2008;10(2):140-7.
2007: Andrea Christoforou; Stéphanie Le Hellard; Pippa A Thomson; stewart morris; A Tenesa; Ben S Pickard; Naomi R Wray; Walter J Muir; D H R Blackwood; David J Porteous; Kathryn L Evans
Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.
Molecular psychiatry 2007;12(11):1011-25.
2007: J Kirsty Millar; Shaun Mackie; Steven J Clapcote; Hannah Murdoch; Ben S Pickard; Sheila Christie; Walter J Muir; D H R Blackwood; John C Roder; Miles D Houslay; David J Porteous
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.
The Journal of physiology 2007;584(Pt 2):401-5.
2007: Ben S Pickard; Pippa A Thomson; Andrea Christoforou; Kathryn L Evans; stewart morris; David J Porteous; D H R Blackwood; Walter J Muir
The PDE4B gene confers sex-specific protection against schizophrenia.
Psychiatric genetics 2007;17(3):129-33.
2007: Stéphanie Le Hellard; Andrew J Lee; Sarah Underwood; Pippa A Thomson; stewart morris; Helen S Torrance; Susan M Anderson; Richard R Adams; Pau Navarro; Andrea Christoforou; Lorna M Houlihan; Sevilla D Detera-Wadleigh; Michael J Owen; Philip Asherson; Walter J Muir; D H R Blackwood; Naomi R Wray; David J Porteous; Kathryn L Evans
Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder.
Biological psychiatry 2007;61(6):797-805.
2007: D H R Blackwood; Ben J Pickard; Pippa A Thomson; Kathryn L Evans; David J Porteous; Walter J Muir
Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1.
Neurotoxicity research 2007;11(1):73-83.
2007: Leonie Boeing; Val Murray; Anthony Pelosi; Robert McCabe; D H R Blackwood; Robert Wrate
Adolescent-onset psychosis: prevalence, needs and service provision.
The British journal of psychiatry : the journal of mental science 2007;190():18-26.
2007: Pippa A Thomson; Andrea Christoforou; stewart morris; Euan Adie; Ben S Pickard; David J Porteous; Walter J Muir; D H R Blackwood; Kathryn L Evans
Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population.
Molecular psychiatry 2007;12(1):94-104.
2006: J E Severinsen; Carsten R Bjarkam; S Kiaer-Larsen; I M Olsen; Morten Muhlig Nielsen; J Blechingberg; Anders Lade Nielsen; Ida E Holm; Leslie Foldager; B D Young; Walter J Muir; D H R Blackwood; Thomas J Corydon; Ole Mors; Anders D Børglum
Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder.
Molecular psychiatry 2006;11(12):1126-38.
2006: Ben S Pickard; M Pat Malloy; Andrea Christoforou; Pippa A Thomson; Kathryn L Evans; stewart morris; M Hampson; David J Porteous; D H R Blackwood; Walter J Muir
Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder.
Molecular psychiatry 2006;11(9):847-57.
2006: J E Severinsen; Thomas D Als; Helle Glud Binderup; Torben A Kruse; August Wang; Maria Vang; Walter J Muir; D H R Blackwood; Ole Mors; Anders D Børglum
Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(5):524-33.
2006: Walter J Muir; Ben S Pickard; D H R Blackwood
Chromosomal abnormalities and psychosis.
The British journal of psychiatry : the journal of mental science 2006;188():501-3.
2006: S L Underwood; Andrea Christoforou; Pippa A Thomson; Naomi R Wray; A Tenesa; J Whittaker; R A Adams; Stéphanie Le Hellard; stewart morris; D H R Blackwood; Walter J Muir; David J Porteous; Kathryn L Evans
Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia.
Molecular psychiatry 2006;11(4):384-94.
2006: Ben S Pickard; Andrew A Pieper; David J Porteous; D H R Blackwood; Walter J Muir
The NPAS3 gene--emerging evidence for a role in psychiatric illness.
Annals of medicine 2006;38(6):439-48.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Ben S Pickard; M Pat Malloy; David J Porteous; D H R Blackwood; Walter J Muir
Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):26-32.
2005: Daniel J Smith; Laura Duffy; Mary E Stewart; Walter J Muir; D H R Blackwood
High harm avoidance and low self-directedness in euthymic young adults with recurrent, early-onset depression.
Journal of affective disorders 2005;87(1):83-9.
2005: Daniel J Smith; Walter J Muir; D H R Blackwood
Borderline personality disorder characteristics in young adults with recurrent mood disorders: a comparison of bipolar and unipolar depression.
Journal of affective disorders 2005;87(1):17-23.
2005: Pippa A Thomson; Naomi R Wray; J Kirsty Millar; Kathryn L Evans; S Le Hellard; A Condie; Walter J Muir; D H R Blackwood; David J Porteous
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.
Molecular psychiatry 2005;10(7):657-68, 616.
2005: Mikkel D Lundorf; H N Buttenschøn; Leslie Foldager; D H R Blackwood; Walter J Muir; V Murray; Anthony Pelosi; Torben A Kruse; Henrik Ewald; Ole Mors
Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;135B(1):94-101.
2005: Pippa A Thomson; Naomi R Wray; A M Thomson; Donald Dunbar; M A Grassie; A Condie; M T Walker; Daniel J Smith; D J Pulford; Walter Muir; D H R Blackwood; David J Porteous
Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.
Molecular psychiatry 2005;10(5):470-8.
2005: V Murray; I McKee; P McC Miller; D Young; Walter J Muir; Anthony Pelosi; D H R Blackwood
Dimensions and classes of psychosis in a population cohort: a four-class, four-dimension model of schizophrenia and affective psychoses.
Psychological medicine 2005;35(4):499-510.
2005: Ben S Pickard; M Pat Malloy; Leanne Clark; Stéphanie Lehellard; Henrik Ewald; Ole Mors; David J Porteous; D H R Blackwood; Walter J Muir
Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18.
Psychiatric genetics 2005;15(1):37-44.
2005: Peter M Visscher; Chris S Haley; Henrik Ewald; Ole Mors; Janice A Egeland; B Thiel; Edward I Ginns; Walter Muir; D H R Blackwood
Joint multi-population analysis for genetic linkage of bipolar disorder or "wellness" to chromosome 4p.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;133B(1):18-24.
2005: Daniel J Smith; Nadine Harrison; Walter Muir; D H R Blackwood
The high prevalence of bipolar spectrum disorders in young adults with recurrent depression: toward an innovative diagnostic framework.
Journal of affective disorders 2005;84(2-3):167-78.
2005: Ben S Pickard; J Kirsty Millar; David J Porteous; W J Muir; D H R Blackwood
Cytogenetics and gene discovery in psychiatric disorders.
The pharmacogenomics journal 2005;5(2):81-8.
2004: Stuart Macgregor; Peter M Visscher; Sara A Knott; P Thomson; David J Porteous; J Kirsty Millar; Rebecca S Devon; D H R Blackwood; Walter J Muir
A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.
Molecular psychiatry 2004;9(12):1083-90.
2004: Ben S Pickard; Ed Hollox; M Pat Malloy; David J Porteous; D H R Blackwood; John A L Armour; Walter J Muir
A 4q35.2 subtelomeric deletion identified in a screen of patients with co-morbid psychiatric illness and mental retardation.
BMC medical genetics 2004;5():21.
2004: Daniel J Smith; Walter J Muir; D H R Blackwood
Is borderline personality disorder part of the bipolar spectrum?
Harvard review of psychiatry 2004;12(3):133-9.
2004: D H R Blackwood; Walter J Muir
Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia.
Neurotoxicity research 2004;6(1):35-41.
2003: D J MacIntyre; D H R Blackwood; David J Porteous; Ben S Pickard; Walter J Muir
Chromosomal abnormalities and mental illness.
Molecular psychiatry 2003;8(3):275-87.
2003: J Kirsty Millar; Pippa A Thomson; Naomi R Wray; Walter J Muir; D H R Blackwood; David J Porteous
Response to Amar J. Klar: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders.
Genetics 2003;163(2):833-5; author reply 837-8.
2003: Anders D Børglum; G Kirov; N Craddock; Ole Mors; Walter Muir; V Murray; I McKee; David A Collier; Henrik Ewald; Michael J Owen; D H R Blackwood; Torben A Kruse
Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;117B(1):18-22.
2003: David J Porteous; Kathryn L Evans; J Kirsty Millar; Ben S Pickard; Pippa A Thomson; R James; S MacGregor; Naomi R Wray; P M Visscher; Walter J Muir; D H R Blackwood
Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes.
Cold Spring Harbor symposia on quantitative biology 2003;68():383-94.
2002: Stuart Macgregor; Peter M Visscher; Sara A Knott; David J Porteous; Walter Muir; Kirsty Millar; D H R Blackwood
Is schizophrenia linked to chromosome 1q?
Science (New York, N.Y.) 2002;298(5602):2277; author reply 2277.
2002: Stéphanie Le Hellard; Stéphane J Ballereau; Peter M Visscher; Helen S Torrance; Jeni Pinson; stewart morris; Marian L Thomson; Colin Semple; Walter J Muir; D H R Blackwood; David J Porteous; Kathryn L Evans
SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis.
Nucleic acids research 2002;30(15):e74.
2002: J T O Cavanagh; M Van Beck; Walter Muir; D H R Blackwood
Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania.
The British journal of psychiatry : the journal of mental science 2002;180():320-6.
2001: Anders D Børglum; M Hampson; T E Kjeldsen; Walter Muir; V Murray; Henrik Ewald; Ole Mors; D H R Blackwood; Torben A Kruse
Dopa decarboxylase genotypes may influence age at onset of schizophrenia.
Molecular psychiatry 2001;6(6):712-7.
2001: Peter M Visscher; M H Yazdi; A D Jackson; Martin Schalling; Kerstin Lindblad; Qiu-Ping Yuan; David J Porteous; Walter J Muir; D H R Blackwood
Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families.
Psychiatric genetics 2001;11(3):129-37.
2001: D H R Blackwood; A Fordyce; M T Walker; D M St Clair; David J Porteous; Walter J Muir
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.
American journal of human genetics 2001;69(2):428-33.
2001: Rebecca S Devon; S Anderson; PW Teague; P Burgess; T M Kipari; Colin Semple; J Kirsty Millar; Walter J Muir; V Murray; Anthony Pelosi; D H R Blackwood; David J Porteous
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.
Psychiatric genetics 2001;11(2):71-8.
2001: Rebecca S Devon; S Anderson; PW Teague; Walter J Muir; V Murray; Anthony Pelosi; D H R Blackwood; David J Porteous
The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia.
Molecular psychiatry 2001;6(3):311-4.
2001: Walter J Muir; M L Thomson; Patrick McKeon; Lesley Mynett-Johnson; Claire Whitton; Kathryn L Evans; David J Porteous; D H R Blackwood
Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder.
American journal of medical genetics 2001;105(2):152-8.
2001: J Kirsty Millar; S Christie; S Anderson; D Lawson; Dawn Loh; Rebecca S Devon; B Arveiler; Walter J Muir; D H R Blackwood; David J Porteous
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.
Molecular psychiatry 2001;6(2):173-8.
2001: Kathryn L Evans; Stéphanie Le Hellard; stewart morris; D Lawson; Claire Whitton; Colin Semple; Judy A Fantes; Helen S Torrance; M Pat Malloy; John Maule; Sean Humphray; Mark T Ross; David R Bentley; Walter J Muir; D H R Blackwood; David J Porteous
A 6.9-Mb high-resolution BAC/PAC contig of human 4p15.3-p16.1, a candidate region for bipolar affective disorder.
Genomics 2001;71(3):315-23.
2001: Kathryn L Evans; Walter J Muir; D H R Blackwood; David J Porteous
Nuts and bolts of psychiatric genetics: building on the Human Genome Project.
Trends in genetics : TIG 2001;17(1):35-40.
2000: J Kirsty Millar; JC Wilson-Annan; S Anderson; Sheila Christie; Martin Taylor; Colin Semple; Rebecca S Devon; D M St Clair; Walter J Muir; D H R Blackwood; David J Porteous
Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Human molecular genetics 2000;9(9):1415-23.
2000: Kathryn L Evans; D Lawson; Thomas Meitinger; D H R Blackwood; David J Porteous
Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder.
American journal of medical genetics 2000;96(2):158-60.
1999: Peter M Visscher; Chris S Haley; S C Heath; Walter J Muir; D H R Blackwood
Detecting QTLs for uni- and bipolar disorder using a variance component method.
Psychiatric genetics 1999;9(2):75-84.
1999: S Battersby; Alan D Ogilvie; D H R Blackwood; S Shen; M M Muqit; Walter J Muir; PW Teague; Guy M Goodwin; Anthony J Harmar
Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene.
Journal of neurochemistry 1999;72(4):1384-8.
1998: Julie Williams; Gillian Spurlock; Peter Holmans; R Mant; K Murphy; Lesley Jones; Alastair G Cardno; Philip Asherson; D H R Blackwood; Walter Muir; Kurt Meszaros; Harald N Aschauer; J Mallet; C Laurent; P Pekkarinen; J Seppala; Costas N Stefanis; George N Papadimitriou; Fabio Macciardi; M Verga; C Pato; H Azevedo; M A Crocq; Hugh M D Gurling; Michael J Owen
A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia.
Molecular psychiatry 1998;3(2):141-9.
1998: J Kirsty Millar; J Brown; John Maule; Y Shibasaki; Sheila Christie; D Lawson; S Anderson; JC Wilson-Annan; Rebecca S Devon; D M St Clair; D H R Blackwood; Walter J Muir; David J Porteous
A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes.
Psychiatric genetics 1998;8(3):175-81.
1997: JC Wilson-Annan; D H R Blackwood; Walter Muir; J Kirsty Millar; David J Porteous
An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) that co-segregates with mental illness.
Psychiatric genetics 1997;7(4):171-4.