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Donald Schmechel

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Winnie S Liang; Travis Dunkley; Thomas Beach; Andrew Grover; Diego Mastroeni; Keri Ramsey; Richard Caselli; Walter A Kukull; Daniel W McKeel; John C Morris; Christine M Hulette; Donald E Schmechel; Eric Reiman; Joseph Rogers; Dietrich A Stephan
Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology.
Stephan Zuchner; John Gilbert; Eden R Martin; C R Leon-Guerrero; P-T Xu; C Browning; P G Bronson; P Whitehead; Donald E Schmechel; Jonathan L Haines; Margaret Pericak-Vance
Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3.
Patrick M. Sullivan; Brian E Mace; Januario C Estrada; Donald E Schmechel; Mark J Alberts
Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.

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All Publications

2010: Winnie S Liang; Travis Dunkley; Thomas Beach; Andrew Grover; Diego Mastroeni; Keri Ramsey; Richard Caselli; Walter A Kukull; Daniel W McKeel; John C Morris; Christine M Hulette; Donald E Schmechel; Eric Reiman; Joseph Rogers; Dietrich A Stephan
Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology.
Neurobiology of aging 2010;31(4):549-66.
2008: Stephan Zuchner; John Gilbert; Eden R Martin; C R Leon-Guerrero; P-T Xu; C Browning; P G Bronson; P Whitehead; Donald E Schmechel; Jonathan L Haines; Margaret Pericak-Vance
Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3.
Annals of human genetics 2008;72(Pt 6):725-31.
2008: Patrick M. Sullivan; Brian E Mace; Januario C Estrada; Donald E Schmechel; Mark J Alberts
Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2008;17(5):303-11.
2008: R M Carney; Michael Slifer; Ping-I Lin; Perry C Gaskell; William Scott; C F Potocky; C M Hulette; Kathleen A Welsh-Bohmer; Donald E Schmechel; Jeffery Vance; Margaret Pericak-Vance
Longitudinal follow-up of late-onset Alzheimer disease families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(5):571-8.
2008: Jeffrey Browndyke; James Paskavitz; Lawrence H Sweet; Ronald A Cohen; Karen A Tucker; Kathleen A Welsh-Bohmer; James R Burke; Donald E Schmechel
Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task.
Brain injury : [BI] 2008;22(6):481-9.
2008: Winnie S Liang; Travis Dunkley; Thomas Beach; Andrew Grover; Diego Mastroeni; Keri Ramsey; Richard Caselli; Walter A Kukull; Daniel W McKeel; John C Morris; Christine M Hulette; Donald E Schmechel; Eric Reiman; Joseph Rogers; Dietrich A Stephan
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.
Physiological genomics 2008;33(2):240-56.
2008: Winnie S Liang; Eric Reiman; Jonathan Valla; Travis Dunkley; Thomas Beach; Andrew Grover; Tracey L Niedzielko; Lonnie E Schneider; Diego Mastroeni; Richard Caselli; Walter A Kukull; John C Morris; Christine M Hulette; Donald E Schmechel; Joseph Rogers; Dietrich A Stephan
Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4441-6.
2008: Xueying Liang; Nathalie Schnetz-Boutaud; Jackie Bartlett; Melissa J Allen; Harry E Gwirtsman; Donald E Schmechel; Regina M Carney; John Gilbert; Margaret Pericak-Vance; Jonathan L Haines
No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets.
Annals of human genetics 2008;72(Pt 1):141-4.
2007: Christopher L Edwards; Renee Dunn Raynor; Miriam Feliu; Camela McDougald; Stephanie Johnson; Donald E Schmechel; Mary Wood; Gary Bennett; Patrick Saurona; Melanie Bonner; Chante' Wellington; Laura M DeCastro; Elaine Whitworth; Mary Abrams; Patrick E Logue; Lekisha Edwards; Salutario Martinez; Keith E Whitfield
Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD).
Neuropsychiatric disease and treatment 2007;3(6):705-9.
2007: Pu-Ting Xu; Yi-Ju Li; Xue-Jun Qin; Charles C Kroner; Anya Green-Odlum; Hong Xu; Tian-Yuan Wang; Donald E Schmechel; Christine M Hulette; John F Ervin; Mike Hauser; Jonathan L Haines; Margaret Pericak-Vance; John Gilbert
A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.
Molecular and cellular neurosciences 2007;36(3):313-31.
2007: Xueying Liang; Eden R Martin; Nathalie Schnetz-Boutaud; Jackie Bartlett; Brent Anderson; Stephan Zuchner; Harry E Gwirtsman; Donald E Schmechel; Regina Carney; John Gilbert; Margaret Pericak-Vance; Jonathan L Haines
Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease.
Human mutation 2007;28(11):1065-73.
2007: Donald E Schmechel
Art, alpha-1-antitrypsin polymorphisms and intense creative energy: blessing or curse?
Neurotoxicology 2007;28(5):899-914.
2007: Jeremy Sugarman; Debra Roter; Carole Cain; Roberta Wallace; Donald E Schmechel; Kathleen A Welsh-Bohmer
Proxies and consent discussions for dementia research.
Journal of the American Geriatrics Society 2007;55(4):556-61.
2007: Winnie S Liang; Travis Dunkley; Thomas Beach; Andrew Grover; Diego Mastroeni; Douglas G. Walker; Richard Caselli; Walter A Kukull; Daniel W McKeel; John C Morris; Christine M Hulette; Donald E Schmechel; Gene Alexander; Eric Reiman; Joseph Rogers; Dietrich A Stephan
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
Physiological genomics 2007;28(3):311-22.
2007: Xueying Liang; Nathalie Schnetz-Boutaud; Jackie Bartlett; Brent M Anderson; Harry E Gwirtsman; Donald E Schmechel; Regina Carney; John Gilbert; Margaret Pericak-Vance; Jonathan L Haines
Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease.
Dementia and geriatric cognitive disorders 2007;23(2):126-32.
2006: Travis Dunkley; Thomas Beach; Keri E Ramsey; Andrew Grover; Diego Mastroeni; Douglas G. Walker; Bonnie LaFleur; Keith D Coon; Kevin Brown; Richard Caselli; Walter A Kukull; Roger Higdon; Daniel W McKeel; John C Morris; Christine M Hulette; Donald E Schmechel; Eric Reiman; Joseph Rogers; Dietrich A Stephan
Gene expression correlates of neurofibrillary tangles in Alzheimer's disease.
Neurobiology of aging 2006;27(10):1359-71.
2006: Donald E Schmechel; Jeffrey Browndyke; Andrew J Ghio
Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.
Neurotoxicology 2006;27(5):637-57.
2006: Ping-I Lin; Eden R Martin; PG Bronson; Carrie A Browning-Large; Gary W Small; Donald E Schmechel; Kathleen A Welsh-Bohmer; Jonathan L Haines; John Gilbert; Margaret Pericak-Vance
Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.
Neurology 2006;67(1):64-8.
2006: Ping-I Lin; Eden R Martin; Carrie A Browning-Large; Donald E Schmechel; Kathleen A Welsh-Bohmer; P Murali Doraiswamy; John Gilbert; Jonathan L Haines; Margaret Pericak-Vance
Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis.
Neurogenetics 2006;7(3):157-65.
2006: Pu-Ting Xu; Yi-Ju Li; Xue-Jun Qin; Clemens R Scherzer; Hong Xu; Donald E Schmechel; Christine M Hulette; John F Ervin; Steven R Gullans; Jonathan L Haines; Margaret Pericak-Vance; John Gilbert
Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.
Neurobiology of disease 2006;21(2):256-75.
2006: Goldis Malek; Brian E Mace; Peter Saloupis; Donald E Schmechel; Dennis W Rickman; Patrick M. Sullivan; Catherine Bowes Rickman
Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice.
Advances in experimental medicine and biology 2006;572():109-17.
2006: Yi-Ju Li; Puting Xu; Xuejun Qin; Donald E Schmechel; Christine M Hulette; Jonathan L Haines; Margaret Pericak-Vance; John Gilbert
A comparative analysis of the information content in long and short SAGE libraries.
BMC bioinformatics 2006;7():504.
2005: Eden R Martin; PG Bronson; Y-J Li; N Wall; Ren-Hua Chung; Donald E Schmechel; Gary W Small; Pu-Ting Xu; J Bartlett; Nathalie Schnetz-Boutaud; Jonathan L Haines; John Gilbert; Margaret Pericak-Vance
Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease.
Journal of medical genetics 2005;42(10):787-92.
2005: Maher A Noureddine; Yi-Ju Li; Joelle M van der Walt; Robert Walters; Rita M Jewett; Hong Xu; Tianyuan Wang; Jeffrey W Walter; Burton L Scott; Christine M Hulette; Donald E Schmechel; Judith E Stenger; Fred S Dietrich; Jeffery Vance; Michael A Hauser
Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra.
Movement disorders : official journal of the Movement Disorder Society 2005;20(10):1299-309.
2005: Goldis Malek; L V Johnson; Brian E Mace; Peter Saloupis; Donald E Schmechel; Dennis W Rickman; Cynthia A Toth; Patrick M. Sullivan; Catherine Bowes Rickman
Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11900-5.
2005: Elizabeth H Corder; John F Ervin; Evelyn Lockhart; Mari H Szymanski; Donald E Schmechel; Christine M Hulette
Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC.
Journal of biomedicine & biotechnology 2005;2005(2):189-97.
2005: Michael A Hauser; Yi-Ju Li; Hong Xu; Maher A Noureddine; Yujun S Shao; Steven R Gullans; Clemens R Scherzer; Roderick V Jensen; Adam C McLaurin; Jason R Gibson; Burton L Scott; Rita M Jewett; Judith E Stenger; Donald E Schmechel; Christine M Hulette; Jeffery Vance
Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism.
Archives of neurology 2005;62(6):917-21.
2005: Ryan T Mott; dennis dickson; John Q Trojanowski; Victoria Zhukareva; Virginia M-Y Lee; Mark Forman; Vivianna M Van Deerlin; John F Ervin; Dengshun Wang; Donald E Schmechel; Christine M Hulette
Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias.
Journal of neuropathology and experimental neurology 2005;64(5):420-8.
2005: Chunsheng Wang; Wilkie A Wilson; Scott D Moore; Brian E Mace; Nobuyo Maeda; Donald E Schmechel; Patrick M. Sullivan
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.
Neurobiology of disease 2005;18(2):390-8.
2004: Kristin K Nicodemus; Judith E Stenger; Donald E Schmechel; Kathleen A Welsh-Bohmer; Ann M Saunders; Allen D Roses; John Gilbert; Jeffery Vance; Jonathan L Haines; Margaret Pericak-Vance; Eden R Martin
Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease.
Neurogenetics 2004;5(4):201-8.
2004: Joelle M van der Walt; Yulia A Dementieva; Eden R Martin; William Scott; Kristin K Nicodemus; Charles C Kroner; Kathleen A Welsh-Bohmer; Ann M Saunders; Allen D Roses; Gary W Small; Donald E Schmechel; P Murali Doraiswamy; John Gilbert; Jonathan L Haines; Jeffery Vance; Margaret Pericak-Vance
Analysis of European mitochondrial haplogroups with Alzheimer disease risk.
Neuroscience letters 2004;365(1):28-32.
2004: John F Ervin; Catherine Pannell; Mari Szymanski; Kathleen A Welsh-Bohmer; Donald E Schmechel; Christine M Hulette
Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis.
Journal of neuropathology and experimental neurology 2004;63(7):735-41.
2004: Carol A. Colton; Leila K Needham; Candice Brown; Danielle Cook; Karima Rasheed; James R Burke; Warren J Strittmatter; Donald E Schmechel; Michael P. Vitek
APOE genotype-specific differences in human and mouse macrophage nitric oxide production.
Journal of neuroimmunology 2004;147(1-2):62-7.
2004: Patrick M. Sullivan; Brian E Mace; Nobuyo Maeda; Donald E Schmechel
Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice.
Neuroscience 2004;124(4):725-33.
2003: Yi-Ju Li; Sofia A Oliveira; Puting Xu; Eden R Martin; Judith E Stenger; Clemens R Scherzer; Michael A Hauser; William Scott; Gary W Small; Martha A Nance; Ray L Watts; Jean P Hubble; William Koller; Rajesh Pahwa; Matthew B Stern; Bradley C Hiner; Joseph Jankovic; Christopher G Goetz; Frank L Mastaglia; Lefkos T Middleton; Allen D Roses; Ann M Saunders; Donald E Schmechel; Steven R Gullans; Jonathan L Haines; John Gilbert; Jeffery Vance; Margaret Pericak-Vance; Christine M Hulette; Kathleen A Welsh-Bohmer
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
Human molecular genetics 2003;12(24):3259-67.
2003: William Scott; Elizabeth R Hauser; Donald E Schmechel; Kathleen A Welsh-Bohmer; Gary W Small; Allen D Roses; Ann M Saunders; John Gilbert; Jeffery Vance; Jonathan L Haines; Margaret Pericak-Vance
Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22.
American journal of human genetics 2003;73(5):1041-51.
2003: Shalini L Kulasingam; Gregory P Samsa; Deborah A Zarin; Olivier T Rutschmann; Meenal B Patwardhan; Douglas C McCrory; Donald E Schmechel; David B Matchar
When should functional neuroimaging techniques be used in the diagnosis and management of Alzheimer's dementia? A decision analysis.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2003;6(5):542-50.
2003: Sofia A Oliveira; Eden R Martin; William Scott; Kristin K Nicodemus; Gary W Small; Donald E Schmechel; P Murali Doraiswamy; Allen D Roses; Ann M Saunders; John Gilbert; Jonathan L Haines; Jeffery Vance; Margaret Pericak-Vance
The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease.
Neuroscience letters 2003;347(3):143-6.
2003: Yuri Trembath; Carolyn Rosenberg; John F Ervin; Donald E Schmechel; Perry C Gaskell; Margaret Pericak-Vance; Jeffery Vance; Christine M Hulette
Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease.
Acta neuropathologica 2003;105(5):484-8.
2003: Joelle M van der Walt; Kristin K Nicodemus; Eden R Martin; William Scott; Martha A Nance; Ray L Watts; Jean P Hubble; Jonathan L Haines; William Koller; Kelly E Lyons; Rajesh Pahwa; Matthew B Stern; Amy Colcher; Bradley C Hiner; Joseph Jankovic; William G Ondo; Fred H Allen; Christopher G Goetz; Gary W Small; Frank L Mastaglia; Jeffrey M Stajich; Adam C McLaurin; Lefkos T Middleton; Burton L Scott; Donald E Schmechel; Margaret Pericak-Vance; Jeffery Vance
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease.
American journal of human genetics 2003;72(4):804-11.
2003: Michael A Hauser; Yi-Ju Li; Satoshi Takeuchi; Robert Walters; Maher A Noureddine; Melinda Maready; Tiffany Darden; Christine M Hulette; Eden R Martin; Elizabeth R Hauser; Hong Xu; Donald E Schmechel; Judith E Stenger; Fred S Dietrich; Jeffery Vance
Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage.
Human molecular genetics 2003;12(6):671-7.
2002: Carol A. Colton; Candice Brown; Danielle Cook; Leila K Needham; Qing Xu; Meggan Czapiga; Ann M Saunders; Donald E Schmechel; Karima Rasheed; Michael P. Vitek
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.
Neurobiology of aging 2002;23(5):777-85.
2002: Marian Swinker; Patricia Tester; Deborah Koltai Attix; Donald E Schmechel
Human health effects of exposure to Pfiesteria piscicida: a review.
Microbes and infection / Institut Pasteur 2002;4(7):751-62.
2002: Yi-Ju Li; William Scott; Dale Hedges; Fengyu Zhang; P Craig Gaskell; Martha A Nance; Ray L Watts; Jean P Hubble; William Koller; Rajesh Pahwa; Matthew B Stern; Bradley C Hiner; Joseph Jankovic; Fred A Allen; Christopher G Goetz; Frank Mastaglia; Jeffrey M Stajich; Rachel A Gibson; Lefkos T Middleton; Ann M Saunders; Burton L Scott; Gary W Small; Kristin K Nicodemus; Allison D Reed; Donald E Schmechel; Kathleen A Welsh-Bohmer; P Michael Conneally; Allen D Roses; John Gilbert; Jeffery Vance; Jonathan L Haines; Margaret Pericak-Vance
Age at onset in two common neurodegenerative diseases is genetically controlled.
American journal of human genetics 2002;70(4):985-93.
2001: Donald E Schmechel; D C Koltai
Potential human health effects associated with laboratory exposures to Pfiesteria piscicida.
Environmental health perspectives 2001;109 Suppl 5():775-9.
2001: C E Clayton; Martha Sue Carraway; Hagir Suliman; Edward D Thalmann; K N Thalmann; Donald E Schmechel; Claude A Piantadosi
Inhaled carbon monoxide and hyperoxic lung injury in rats.
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L949-57.
2001: Marian Swinker; D Koltai; J Wilkins; K Hudnell; C Hall; D Darcey; K Robertson; Donald E Schmechel; W Stopford; S Music
Estuary-associated syndrome in North Carolina: an occupational prevalence study.
Environmental health perspectives 2001;109(1):21-6.
2000: G Jean Harry; Christian Lefebvre d'Hellencourt; Alessandra Bruccoleri; Donald E Schmechel
Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice.
Brain, behavior, and immunity 2000;14(4):288-304.
2000: Eden R Martin; Eric H Lai; John Gilbert; AR Rogala; A J Afshari; John Riley; K L Finch; J F Stevens; K J Livak; BD Slotterbeck; Susan H Slifer; LL Warren; PM Conneally; Donald E Schmechel; Ian Purvis; Margaret Pericak-Vance; Allen D Roses; Jeffery Vance
SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.
American journal of human genetics 2000;67(2):383-94.
2000: Daniel T Laskowitz; DM Lee; Donald E Schmechel; Herman F Staats
Altered immune responses in apolipoprotein E-deficient mice.
Journal of lipid research 2000;41(4):613-20.
2000: Eden R Martin; John Gilbert; Eric H Lai; John Riley; AR Rogala; BD Slotterbeck; C A Sipe; Janet Grubber; LL Warren; PM Conneally; Ann M Saunders; Donald E Schmechel; Ian Purvis; Margaret Pericak-Vance; Allen D Roses; Jeffery Vance
Analysis of association at single nucleotide polymorphisms in the APOE region.
Genomics 2000;63(1):7-12.
1999: Christine M Hulette; Margaret Pericak-Vance; Allen D Roses; Donald E Schmechel; LH Yamaoka; Perry C Gaskell; Kathleen A Welsh-Bohmer; R A Crowther; Maria Grazia Spillantini
Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684.
Journal of neuropathology and experimental neurology 1999;58(8):859-66.
1999: Edward D Levin; BB Simon; Donald E Schmechel; Howard B Glasgow; NJ Deamer-Melia; JoAnn M Burkholder; Virginia C Moser; K Jensen; G Jean Harry
Pfiesteria toxin and learning performance.
Neurotoxicology and teratology 1999;21(3):215-21.
1999: E A Rogaeva; S Premkumar; Janet Grubber; L Serneels; William Scott; T Kawarai; Y Song; D L Hill; S M Abou-Donia; Eden R Martin; Jeffery Vance; Gang G. Yu; A Orlacchio; Y Pei; M Nishimura; Agnes Supala; B Roberge; Ann M Saunders; Allen D Roses; Donald E Schmechel; A Crane-Gatherum; Sandro Sorbi; A Bruni; Gary W Small; P M Conneally; Jonathan L Haines; Fred Van Leuven; Peter St George-Hyslop; Lindsay A Farrer; Margaret Pericak-Vance
An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.
Nature genetics 1999;22(1):19-22.
1999: Pu-Ting Xu; Donald E Schmechel; HL Qiu; Michael H Herbstreith; TR Rothrock-Christian; M Eyster; Allen D Roses; John Gilbert
Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.
Neurobiology of disease 1999;6(1):63-75.
1999: Pu-Ting Xu; John Gilbert; HL Qiu; John F Ervin; TR Rothrock-Christian; Christine M Hulette; Donald E Schmechel
Specific regional transcription of apolipoprotein E in human brain neurons.
The American journal of pathology 1999;154(2):601-11.
1998: Gillian Einstein; V Patel; P Bautista; M Kenna; L Melone; R Fader; K Karson; S Mann; Ann M Saunders; Christine M Hulette; Deborah C Mash; Allen D Roses; Donald E Schmechel
Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology.
Journal of neuropathology and experimental neurology 1998;57(12):1190-201.
1998: Pu-Ting Xu; John Gilbert; HL Qiu; TR Rothrock-Christian; D L Settles; Allen D Roses; Donald E Schmechel
Regionally specific neuronal expression of human APOE gene in transgenic mice.
Neuroscience letters 1998;246(2):65-8.
1998: Huaxin Sheng; Daniel T Laskowitz; E Bennett; Donald E Schmechel; RD Bart; Ann M Saunders; Robert D Pearlstein; Allen D Roses; David S Warner
Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(4):361-6.
1998: Daniel T Laskowitz; William D. Matthew; Ellen R Bennett; Donald E Schmechel; Michael H Herbstreith; S Goel; Michael McMillian
Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.
Neuroreport 1998;9(4):615-8.
1998: Allen D Roses; John Gilbert; Pu-Ting Xu; Patrick M. Sullivan; Brian Popko; D S Burkhart; T Christian-Rothrock; Ann M Saunders; Nobuyo Maeda; Donald E Schmechel
Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.
Neurobiology of aging 1998;19(1 Suppl):S53-8.
1997: Edward D Levin; Donald E Schmechel; J B Burkholder; NJ Deamer-Melia; Virginia C Moser; G Jean Harry
Persisting learning deficits in rats after exposure to Pfiesteria piscicida.
Environmental health perspectives 1997;105(12):1320-5.
1997: Claude A Piantadosi; J Zhang; Edward Levin; R J Folz; Donald E Schmechel
Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.
Experimental neurology 1997;147(1):103-14.
1996: LH Yamaoka; Kathleen A Welsh-Bohmer; Christine M Hulette; Perry C Gaskell; M Murray; J L Rimmler; B R Helms; M Guerra; Allen D Roses; Donald E Schmechel; Margaret Pericak-Vance
Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype.
American journal of human genetics 1996;59(6):1306-12.
1996: Donald E Schmechel; D S Burkhart; R Ange; M K Izard
Cholinergic axonal dystrophy and mitochondrial pathology in prosimian primates.
Experimental neurology 1996;142(1):111-27.
1996: S C Lane; R D Jolly; Donald E Schmechel; J Alroy; Rose-Mary N Boustany
Apoptosis as the mechanism of neurodegeneration in Batten's disease.
Journal of neurochemistry 1996;67(2):677-83.
1996: Ann M Saunders; O Hulette; Kathleen A Welsh-Bohmer; Donald E Schmechel; Barbara J Crain; James R Burke; M J Alberts; Warren J Strittmatter; John C S Breitner; Cathy Rosenberg
Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease.
Lancet 1996;348(9020):90-3.
1996: Allen D Roses; Gillian Einstein; John Gilbert; Michel Goedert; S H Han; D Huang; Christine M Hulette; Eliezer Masliah; Margaret Pericak-Vance; Ann M Saunders; Donald E Schmechel; Warren J Strittmatter; Karl H Weisgraber; P T Xi
Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.
Annals of the New York Academy of Sciences 1996;777():146-57.
1996: Pu-Ting Xu; Donald E Schmechel; T Rothrock-Christian; D S Burkhart; H L Qiu; Brian Popko; Patrick M. Sullivan; Nobuyo Maeda; Ann M Saunders; Allen D Roses; John Gilbert
Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.
Neurobiology of disease 1996;3(3):229-45.
1995: Howard B Glasgow; JoAnn M Burkholder; Donald E Schmechel; P A Tester; P A Rublee
Insidious effects of a toxic estuarine dinoflagellate on fish survival and human health.
Journal of toxicology and environmental health 1995;46(4):501-22.
1995: Carmelo Graffagnino; Michael H Herbstreith; Donald E Schmechel; Efrat Levy; Allen D Roses; Mark J Alberts
Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage.
Stroke; a journal of cerebral circulation 1995;26(11):2190-3.
1995: Elizabeth H Corder; Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Perry C Gaskell; J B Rimmler; P A Locke; P M Conneally; Kenneth E Schmader; Rudolph E Tanzi
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.
Neurology 1995;45(7):1323-8.
1995: Allen D Roses; Ann M Saunders; Elizabeth H Corder; Margaret Pericak-Vance; S H Han; Gillian Einstein; Christine M Hulette; Donald E Schmechel; M Holsti; David Y Huang
Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease.
Arzneimittel-Forschung 1995;45(3A):413-7.
1995: Allen D Roses; Ann M Saunders; M A Alberts; Warren J Strittmatter; Donald E Schmechel; E Gorder; Margaret Pericak-Vance
Apolipoprotein E E4 allele and risk of dementia.
JAMA : the journal of the American Medical Association 1995;273(5):374-5; author reply 375-6.
1995: Elizabeth H Corder; Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Perry C Gaskell; Allen D Roses; Margaret Pericak-Vance; Gary W Small; Jonathan L Haines
The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease.
JAMA : the journal of the American Medical Association 1995;273(5):373-4.
1995: Allen D Roses; Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Margaret Pericak-Vance; Bradley T Hyman
Apolipoprotein E in Creutzfeldt-Jacob disease.
Lancet 1995;345(8941):69.
1994: David Y Huang; Michel Goedert; R Jakes; Karl H Weisgraber; C C Garner; Ann M Saunders; Margaret Pericak-Vance; Donald E Schmechel; Allen D Roses; Warren J Strittmatter
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
Neuroscience letters 1994;182(1):55-8.
1994: Warren J Strittmatter; Ann M Saunders; Michel Goedert; Karl H Weisgraber; L M Dong; R Jakes; David Y Huang; Margaret Pericak-Vance; Donald E Schmechel; Allen D Roses
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11183-6.
1994: S H Han; Gillian Einstein; Karl H Weisgraber; Warren J Strittmatter; Ann M Saunders; Margaret Pericak-Vance; Allen D Roses; Donald E Schmechel
Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study.
Journal of neuropathology and experimental neurology 1994;53(5):535-44.
1994: David A Sanan; Karl H Weisgraber; S J Russell; Robert W Mahley; D Huang; Ann M Saunders; Donald E Schmechel; Thomas Wisniewski; Blas Frangione; Allen D Roses
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
The Journal of clinical investigation 1994;94(2):860-9.
1994: S H Han; Christine M Hulette; Ann M Saunders; Gillian Einstein; Margaret Pericak-Vance; Warren J Strittmatter; Allen D Roses; Donald E Schmechel
Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls.
Experimental neurology 1994;128(1):13-26.
1994: Allen D Roses; Warren J Strittmatter; Margaret Pericak-Vance; Elizabeth H Corder; Ann M Saunders; Donald E Schmechel
Clinical application of apolipoprotein E genotyping to Alzheimer's disease.
Lancet 1994;343(8912):1564-5.
1994: Elizabeth H Corder; Ann M Saunders; N J Risch; Warren J Strittmatter; Donald E Schmechel; Perry C Gaskell; J B Rimmler; P A Locke; P M Conneally; Kenneth E Schmader
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.
Nature genetics 1994;7(2):180-4.
1994: Allen D Roses; Margaret Pericak-Vance; Ann M Saunders; Donald E Schmechel; Dmitry Goldgaber; Warren J Strittmatter
Complex genetic disease: can genetic strategies in Alzheimer's disease and new genetic mechanisms be applied to epilepsy?
Epilepsia 1994;35 Suppl 1():S20-8.
1993: Donald E Schmechel; Ann M Saunders; Warren J Strittmatter; Barbara J Crain; Christine M Hulette; S H Joo; Margaret Pericak-Vance; Dmitry Goldgaber; Allen D Roses
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9649-53.
1993: Dmitry Goldgaber; A I Schwarzman; R Bhasin; Luisa Gregori; Donald E Schmechel; Ann M Saunders; Allen D Roses; Warren J Strittmatter
Sequestration of amyloid beta-peptide.
Annals of the New York Academy of Sciences 1993;695():139-43.
1993: Warren J Strittmatter; Karl H Weisgraber; David Y Huang; L M Dong; Guy S Salvesen; Margaret Pericak-Vance; Donald E Schmechel; Ann M Saunders; Dmitry Goldgaber; Allen D Roses
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8098-102.
1993: Elizabeth H Corder; Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Perry C Gaskell; Gary W Small; Allen D Roses; Jonathan L Haines; Margaret Pericak-Vance
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
Science (New York, N.Y.) 1993;261(5123):921-3.
1993: Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Peter St George-Hyslop; Margaret Pericak-Vance; S H Joo; B L Rosi; James Gusella; D R Crapper-MacLachlan; Mark J Alberts
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Neurology 1993;43(8):1467-72.
1993: Warren J Strittmatter; Ann M Saunders; Donald E Schmechel; Margaret Pericak-Vance; Jan J Enghild; Guy S Salvesen; Allen D Roses
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1977-81.
1993: I T Diamond; David Fitzpatrick; Donald E Schmechel
Calcium binding proteins distinguish large and small cells of the ventral posterior and lateral geniculate nuclei of the prosimian galago and the tree shrew (Tupaia belangeri).
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1425-9.
1991: Donald E Schmechel
New approaches to therapy for neurodegenerative diseases.
Southern medical journal 1991;84(5 Suppl 1):S11-23.
1990: Dmitry Goldgaber; Donald E Schmechel
Expression of the amyloid beta-protein precursor gene.
Advances in neurology 1990;51():163-9.
1989: TJ Walsh; D F Emerich; Donald E Schmechel
GM1 ganglioside attenuates the behavioral deficits but not the granule cell damage produced by intradentate colchicine.
Brain research 1989;478(1):24-33.
1988: James J Chrobak; I Hanin; Donald E Schmechel; TJ Walsh
AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates.
Brain research 1988;463(1):107-17.
1988: Donald E Schmechel; Dmitry Goldgaber; D S Burkhart; John Gilbert; D Carleton Gajdusek; Allen D Roses
Cellular localization of messenger RNA encoding amyloid-beta-protein in normal tissue and in Alzheimer disease.
Alzheimer disease and associated disorders 1988;2(2):96-111.
1987: David Fitzpatrick; J S Lund; Donald E Schmechel; A C Towles
Distribution of GABAergic neurons and axon terminals in the macaque striate cortex.
The Journal of comparative neurology 1987;264(1):73-91.
1987: Donald E Schmechel; P J Marangos; Brian M Martin; SL Winfield; D S Burkhart; Allen D Roses; Edward I Ginns
Localization of neuron-specific enolase (NSE) mRNA in human brain.
Neuroscience letters 1987;76(2):233-8.
1987: P J Marangos; Donald E Schmechel
Neuron specific enolase, a clinically useful marker for neurons and neuroendocrine cells.
Annual review of neuroscience 1987;10():269-95.
1987: Albert Heyman; Donald E Schmechel; W Wilkinson; H Rogers; R Krishnan; D Holloway; K Schultz; Lisa P Gwyther; R Peoples; C Utley
Failure of long term high-dose lecithin to retard progression of early-onset Alzheimer's disease.
Journal of neural transmission. Supplementum 1987;24():279-86.
1986: T J Walsh; D W Schulz; H A Tilson; Donald E Schmechel
Colchicine-induced granule cell loss in rat hippocampus: selective behavioral and histological alterations.
Brain research 1986;398(1):23-36.
1986: C S Lin; S M Lu; Donald E Schmechel
Glutamic acid decarboxylase and somatostatin immunoreactivities in rat visual cortex.
The Journal of comparative neurology 1986;244(3):369-83.
1985: Lary Walker; C A Kitt; R G Struble; Donald E Schmechel; Wolfgang H Oertel; L C Cork; Donald L Price
Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques.
Neuroscience letters 1985;59(2):165-9.
1985: G Worley; B Lipman; Ira H Gewolb; J A Green; Donald E Schmechel; C R Roe; S J Gross
Creatine kinase brain isoenzyme: relationship of cerebrospinal fluid concentration to the neurologic condition of newborns and cellular localization in the human brain.
Pediatrics 1985;76(1):15-21.
1985: C S Lin; S M Lu; Donald E Schmechel
Glutamic acid decarboxylase immunoreactivity in layer IV of barrel cortex of rat and mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(7):1934-9.
1985: Mark F Bear; Donald E Schmechel; F F Ebner
Glutamic acid decarboxylase in the striate cortex of normal and monocularly deprived kittens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(5):1262-75.
1985: Richard J Weinberg; M Bentivoglio; K Phend; Donald E Schmechel; Aldo Rustioni
A new double-labeling method demonstrates transmitter-specific projections.
Neuroscience letters 1985;55(3):349-53.
1985: Donald E Schmechel
Gamma-subunit of the glycolytic enzyme enolase: nonspecific or neuron specific?
Laboratory investigation; a journal of technical methods and pathology 1985;52(3):239-42.
1985: J DeFelipe; STEWART HENDRY; Edward G Jones; Donald E Schmechel
Variability in the terminations of GABAergic chandelier cell axons on initial segments of pyramidal cell axons in the monkey sensory-motor cortex.
The Journal of comparative neurology 1985;231(3):364-84.
1984: STEWART HENDRY; Edward G Jones; J DeFelipe; Donald E Schmechel; C Brandon; P C Emson
Neuropeptide-containing neurons of the cerebral cortex are also GABAergic.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(20):6526-30.
1984: G R Penny; M Conley; Donald E Schmechel; I T Diamond
The distribution of glutamic acid decarboxylase immunoreactivity in the diencephalon of the opossum and rabbit.
The Journal of comparative neurology 1984;228(1):38-56.
1984: David Fitzpatrick; G R Penny; Donald E Schmechel
Glutamic acid decarboxylase-immunoreactive neurons and terminals in the lateral geniculate nucleus of the cat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(7):1809-29.
1984: Donald E Schmechel; B G Vickrey; D Fitzpatrick; R P Elde
GABAergic neurons of mammalian cerebral cortex: widespread subclass defined by somatostatin content.
Neuroscience letters 1984;47(3):227-32.
1984: Aldo Rustioni; Donald E Schmechel; S Cheema; D Fitzpatrick
Glutamic acid decarboxylase-containing neurons in the dorsal column nuclei of the cat.
Somatosensory research 1984;1(4):329-57.
1984: Robert Elde; Virginia S Seybold; R L Sorenson; S Cummings; V Holets; D Onstott; C Sasek; Donald E Schmechel; Wolfgang H Oertel
Peptidergic regulation in neuroendocrine and autonomic systems.
Peptides 1984;5 Suppl 1():101-7.
1984: J R Wolff; Vladimir J Balcar; T Zetzsche; H Böttcher; Donald E Schmechel; B M Chronwall
Development of GABA-ergic system in rat visual cortex.
Advances in experimental medicine and biology 1984;181():215-39.
1983: Albert Heyman; W E Wilkinson; B J Hurwitz; Donald E Schmechel; A H Sigmon; T Weinberg; M J Helms; M Swift
Alzheimer's disease: genetic aspects and associated clinical disorders.
Annals of neurology 1983;14(5):507-15.
1983: G R Penny; David Fitzpatrick; Donald E Schmechel; I T Diamond
Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(9):1868-87.
1983: R Spreafico; Donald E Schmechel; L C Ellis; Aldo Rustioni
Cortical relay neurons and interneurons in the N. ventralis posterolateralis of cats: a horseradish peroxidase, electron-microscopic, Golgi and immunocytochemical study.
Neuroscience 1983;9(3):491-509.
1983: Wolfgang H Oertel; Ann M Graybiel; E Mugnaini; R P Elde; Donald E Schmechel; I J Kopin
Coexistence of glutamic acid decarboxylase- and somatostatin-like immunoreactivity in neurons of the feline nucleus reticularis thalami.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(6):1322-32.
1983: T Kirino; M W Brightman; Wolfgang H Oertel; Donald E Schmechel; P J Marangos
Neuron-specific enolase as an index of neuronal regeneration and reinnervation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(5):915-23.
1983: Wolfgang H Oertel; G Riethmüller; E Mugnaini; Donald E Schmechel; A Weindl; C Gramsch; A Herz
Opioid peptide-like immunoreactivity localized in GABAErgic neurons of rat neostriatum and central amygdaloid nucleus.
Life sciences 1983;33 Suppl 1():73-6.
1982: Wolfgang H Oertel; Enrico Mugnaini; M Tappaz; V K Weise; A L Dahl; Donald E Schmechel; I J Kopin
Central GABAergic innervation of neurointermediate pituitary lobe: biochemical and immunocytochemical study in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(2):675-9.
1981: Wolfgang H Oertel; Donald E Schmechel; M J Brownstein; M Tappaz; D H Ransom; I J Kopin
Decrease of glutamate decarboxylase (GAD)-immunoreactive nerve terminals in the substantia nigra after kainic acid lesion of the striatum.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(8):977-80.
1981: M L Tappaz; Michèle Aguera; Marie-Françoise Belin; Wolfgang H Oertel; Donald E Schmechel; I J Kopin; J F Pujol
GABA markers in the hypothalamic median eminence.
Advances in biochemical psychopharmacology 1981;26():229-36.
1981: Wolfgang H Oertel; Donald E Schmechel; V K Weise; D H Ransom; M Tappaz; H C Krutzsch; I J Kopin
Comparison of cysteine sulphinic acid decarboxylase isoenzymes and glutamic acid decarboxylase in rat liver and brain.
Neuroscience 1981;6(12):2701-14.
1981: Wolfgang H Oertel; Donald E Schmechel; M L Tappaz; I J Kopin
Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex.
Neuroscience 1981;6(12):2689-700.
1981: Wolfgang H Oertel; Donald E Schmechel; E Mugnaini; M L Tappaz; I J Kopin
Immunocytochemical localization of glutamate decarboxylase in rat cerebellum with a new antiserum.
Neuroscience 1981;6(12):2715-35.
1980: Wolfgang H Oertel; Donald E Schmechel; J W Daly; M L Tappaz; I J Kopin
Localization of glutamate decarboxylase on line-immunoelectrophoresis and two-dimensional electrophoresis by use of the radioactive suicide substrate [2-3H]-gamma-acetylenic GABA.
Life sciences 1980;27(22):2133-41.
1980: Donald E Schmechel; M W Brightman; P J Marangos
Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation.
Brain research 1980;190(1):195-214.
1980: P J Marangos; Donald E Schmechel; A M Parma; F K Goodwin
Developmental profile of neuron-specific (NSE) and non-neuronal (NNE) enolase.
Brain research 1980;190(1):185-93.
1980: P J Marangos; I C Campbell; Donald E Schmechel; D L Murphy; F K Goodwin
Blood platelets contain a neuron-specific enolase subunit.
Journal of neurochemistry 1980;34(5):1254-8.
1980: Donald E Schmechel; M W Brightman; J L Barker
Localization of neuron-specific enolase in mouse spinal neurons grown in tissue culture.
Brain research 1980;181(2):391-400.
1980: P J Marangos; Donald E Schmechel
The neurobiology of the brain enolases.
Essays in neurochemistry and neuropharmacology 1980;4():211-47.
1979: E Hooghe-Peters; M Dubois-Dalcq; Donald E Schmechel
Visna virus-induced fusion of nerve cells in vitro.
Laboratory investigation; a journal of technical methods and pathology 1979;41(3):247-55.
1979: P J Marangos; Donald E Schmechel; A P Zis; F K Goodwin
The existence and neurobiological significance of neuronal and glial forms of the glycolytic enzyme enolase.
Biological psychiatry 1979;14(4):563-79.
1979: P J Marangos; Donald E Schmechel; A M Parma; R L Clark; F K Goodwin
Measurement of neuron-specific (NSE) and non-neuronal (NNE) isoenzymes of enolase in rat, monkey and human nervous tissue.
Journal of neurochemistry 1979;33(1):319-29.
1979: Donald E Schmechel; P Rakic
A Golgi study of radial glial cells in developing monkey telencephalon: morphogenesis and transformation into astrocytes.
Anatomy and embryology 1979;156(2):115-52.
1979: Donald E Schmechel; P Rakic
Arrested proliferation of radial glial cells during midgestation in rhesus monkey.
Nature 1979;277(5694):303-5.
1978: Donald E Schmechel; P J Marangos; M Brightman
Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells.
Nature 1978;276(5690):834-6.
1978: J Havrankova; Donald E Schmechel; J Roth; M Brownstein
Identification of insulin in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(11):5737-41.
1978: Donald E Schmechel; P J Marangos; A P Zis; M Brightman; F K Goodwin
Brain endolases as specific markers of neuronal and glial cells.
Science (New York, N.Y.) 1978;199(4326):313-5.
1971: Donald E Schmechel; D M Crothers
Kinetic and hydrodynamic studies of the complex of proflavine with poly A-poly U.
Biopolymers 1971;10(3):465-80.