FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Heinz Schmeiser

Research Profile

Chemicals & Drugs

Living Beings

Co-author Network

Publications

TOP 3
M Refik Gökmen; Volker M Arlt; H Terence Cook; Jean-Pierre Cosyns; Joëlle L Nortier; David H Phillips; Heinz H Schmeiser; Monique S J Simmonds; Marie Stiborova; Jean-Louis Vanherweghem; Graham M Lord
The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.
Marie Stiborova; Dagmar Svášková; Žaneta Hejduková; Jaroslav Brotánek; Helena Dračínská; Petr Hodek; Václav Martínek; Jan Milichovský; Heinz H Schmeiser; Eva Frei
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Katerina Levova; Michaela Moserova; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Marie Stiborova
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Heinz Schmeiser (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: M Refik Gökmen; Volker M Arlt; H Terence Cook; Jean-Pierre Cosyns; Joëlle L Nortier; David H Phillips; Heinz H Schmeiser; Monique S J Simmonds; Marie Stiborova; Jean-Louis Vanherweghem; Graham M Lord
The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.
Annals of internal medicine 2013;158(6):469-77.
2013: Marie Stiborova; Dagmar Svášková; Žaneta Hejduková; Jaroslav Brotánek; Helena Dračínská; Petr Hodek; Václav Martínek; Jan Milichovský; Heinz H Schmeiser; Eva Frei
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Chemical research in toxicology 2013;26(2):290-9.
2012: Katerina Levova; Michaela Moserova; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Marie Stiborova
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Toxicology and applied pharmacology 2012;265(3):360-7.
2012: Heinz H Schmeiser; Volker M Arlt; Liviu Daminescu; Cristina Gluhovschi; Gheorghe Gluhovschi; Monica Hollstein; Jill E Kucab; Mirela Modilca; Ligia Petrica; David H Phillips; Silvia Velciov
Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania.
Environmental and molecular mutagenesis 2012;53(8):636-41.
2012: Karel Naiman; Heinz H Schmeiser; Eva Frei; Petr Hodek; Markéta Martínková; Martin Dracínský; Marie Stiborová
Formation, persistence, and identification of DNA adducts formed by the carcinogenic environmental pollutant o-anisidine in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):348-59.
2012: Marie Stiborová; Frantisek Bárta; Eva Frei; Katerina Levová; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Zhanquan Shi; Volker M Arlt
Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(2):345-58.
2012: Marie Stiborova; Lucie Borek-Dohalska; Tereza Cechova; Eva Frei; Michaela Moserova; Jan Paca; Heinz H Schmeiser; Volker M Arlt
Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.
Neuro endocrinology letters 2012;33 Suppl 3():8-15.
2011: Karel Naiman; Heinz H Schmeiser; Eva Frei; Markéta Martínková; Marie Stiborová
Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity.
Mutation research 2011;726(2):160-8.
2011: Volker M Arlt; František Bárta; James D Evans; Eva Frei; Kateřina Levová; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Zhanquan Shi; Marie Stiborová
Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.
Chemical research in toxicology 2011;24(10):1710-9.
2011: Marie Stiborová; Volker M Arlt; Eva Frei; Jaroslav Mareîs; Václav Martínek; Heinz H Schmeiser
The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.
Environmental and molecular mutagenesis 2011;52(6):448-59.
2011: Annette M Krais; Yoon Jung Park; Christoph Plass; Heinz H Schmeiser
Determination of genomic 5-hydroxymethyl-2'-deoxycytidine in human DNA by capillary electrophoresis with laser induced fluorescence.
Epigenetics : official journal of the DNA Methylation Society 2011;6(5):560-5.
2011: Katerina Levová; Michaela Moserová; Vera Kotrbová; Miroslav Sulc; Colin Henderson; C Roland Wolf; David H Phillips; Eva Frei; Heinz H Schmeiser; Jaroslav Mares; Volker M Arlt; Marie Stiborová
Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Toxicological sciences : an official journal of the Society of Toxicology 2011;121(1):43-56.
2011: Jana Mizerovská; Helena Dračínská; Eva Frei; Heinz H Schmeiser; Volker M Arlt; Marie Stiborová
Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats.
Mutation research 2011;720(1-2):34-41.
2011: Marie Stiborova; Frantisek Barta; Eva Frei; Petr Hodek; Katerina Levova; Jaroslav Mares; Jana Pavlickova; Heinz H Schmeiser
Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver.
Neuro endocrinology letters 2011;32 Suppl 1():121-30.
2011: Vaclav Martinek; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Jirí Hudecek; Bozena Kubickova; Marie Stiborova
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.
Neuro endocrinology letters 2011;32 Suppl 1():57-70.
2011: Volker M Arlt; Jie Zuo; Kristina Trenz; Candice A Roufosse; Graham M Lord; Joelle L Nortier; Heinz H Schmeiser; Monica Hollstein; David H Phillips
Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice.
International journal of cancer. Journal international du cancer 2011;128(1):21-32.
2010: Annette M Krais; Michael G Cornelius; Heinz H Schmeiser
Genomic N(6)-methyladenine determination by MEKC with LIF.
Electrophoresis 2010;31(21):3548-51.
2010: Marie Stiborová; Václav Martínek; Martina Svobodová; Jana Sístková; Zdenek Dvorák; Jitka Ulrichová; Vilím Simánek; Eva Frei; Heinz H Schmeiser; David H Phillips; Volker M Arlt
Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone.
Chemical research in toxicology 2010;23(7):1192-201.
2010: Dorothee Funk; Bernd L Sorg; Sabine C Lindner; Heinz H Schmeiser
32P-postlabeling analysis of DNA adducts formed by leukotriene A4 (LTA4).
Environmental and molecular mutagenesis 2010;51(4):338-43.
2010: Agnieszka A Pozdzik; Alix Berton; Heinz H Schmeiser; Wassim Missoum; Christine Decaestecker; Isabelle J Salmon; Jean-Louis Vanherweghem; Joëlle L Nortier
Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity?
Histopathology 2010;56(4):449-63.
2010: Monika Hassel; Michael G Cornelius; Jochen Vom Brocke; Heinz H Schmeiser
Total nucleotide analysis of Hydra DNA and RNA by MEKC with LIF detection and 32P-postlabeling.
Electrophoresis 2010;31(2):299-302.
2009: Gonçalo Gamboa da Costa; Rajinder Singh; Volker M Arlt; Amin Mirza; Meirion Richards; Takeji Takamura-Enya; Heinz H Schmeiser; Peter B Farmer; David H Phillips
Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry.
Chemical research in toxicology 2009;22(11):1860-8.
2009: Heinz H Schmeiser; Gerhard Fürstenberger; Takeji Takamura-Enya; David H Phillips; Volker M Arlt
The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin.
Cancer letters 2009;284(1):21-9.
2009: Marie Stiborová; Václav Martínek; Marcela Semanská; Petr Hodek; Martin Dračínský; Josef Cvačka; Heinz H Schmeiser; Eva Frei
Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study.
Interdisciplinary toxicology 2009;2(3):195-200.
2009: Marie Stiborová; Helena Dracínská; Markéta Martínková; Jana Mizerovská; Jirí Hudecek; Petr Hodek; Jirí Liberda; Eva Frei; Heinz H Schmeiser; David H Phillips; Volker M Arlt
3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.
Mutation research 2009;676(1-2):93-101.
2009: Marie Stiborová; Karel Naiman; Markéta Martínková; Václav Martínek; Martina Svobodová; Heinz H Schmeiser; Eva Frei
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA.
Interdisciplinary toxicology 2009;2(1):24-7.
2009: Marie Stiborova; Eva Frei; Volker M Arlt; Heinz H Schmeiser
The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2009;153(1):5-11.
2009: Jana Mizerovska; Helena Dracinska; Volker M Arlt; Heinz H Schmeiser; Eva Frei; Marie Stiborova
Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes.
Neuro endocrinology letters 2009;30 Suppl 1():52-9.
2009: Heinz H Schmeiser; Marie Stiborovà; Volker M Arlt
Chemical and molecular basis of the carcinogenicity of Aristolochia plants.
Current opinion in drug discovery & development 2009;12(1):141-8.
2009: Jochen Vom Brocke; Annette Krais; Catherine Whibley; Monica Hollstein; Heinz H Schmeiser
The carcinogenic air pollutant 3-nitrobenzanthrone induces GC to TA transversion mutations in human p53 sequences.
Mutagenesis 2009;24(1):17-23.
2008: Volker M Arlt; John Gingerich; Heinz H Schmeiser; David H Phillips; George R Douglas; Paul A White
Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse.
Mutagenesis 2008;23(6):483-90.
2008: Jana Sistkova; Jirí Hudecek; Petr Hodek; Eva Frei; Heinz H Schmeiser; Marie Stiborova
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.
Neuro endocrinology letters 2008;29(5):733-7.
2008: Maria L Simões; Sarah L Hockley; Tanja Schwerdtle; Gonçalo Gamboa da Costa; Heinz H Schmeiser; David H Phillips; Volker M Arlt
Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53.
Toxicology and applied pharmacology 2008;232(1):86-98.
2008: Jana Mizerovská; Helena Dračínská; Volker M Arlt; Jiří Hudeček; Petr Hodek; Heinz H Schmeiser; Eva Frei; Marie Stiborová
Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.
Interdisciplinary toxicology 2008;1(2):150-4.
2008: Karel Naiman; Helena Dracínská; Markéta Martínková; Miroslav Sulc; Martin Dracínský; Lucie Kejíková; Petr Hodek; Jirí Hudecek; Jirí Liberda; Heinz H Schmeiser; Eva Frei; Marie Stiborová
Redox cycling in the metabolism of the environmental pollutant and suspected human carcinogen o-anisidine by rat and rabbit hepatic microsomes.
Chemical research in toxicology 2008;21(8):1610-21.
2008: Marie Stiborová; Jiří Hudeček; Eva Frei; Heinz H Schmeiser
Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answers.
Interdisciplinary toxicology 2008;1(1):8-12.
2008: Marie Stiborová; Eva Frei; Heinz H Schmeiser
Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid.
Kidney international 2008;73(11):1209-11.
2008: Marie Stiborová; Helena Dracínská; Jana Mizerovská; Eva Frei; Heinz H Schmeiser; Jirí Hudecek; Petr Hodek; David H Phillips; Volker M Arlt
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Toxicology 2008;247(1):11-22.
2008: Gisela A Umbuzeiro; Alexandre Franco; Maria Helena Martins; Fábio Kummrow; Lilian Carvalho; Heinz H Schmeiser; Jutta Leykauf; Marie Stiborova; Larry Davis Claxton
Mutagenicity and DNA adduct formation of PAH, nitro-PAH, and oxy-PAH fractions of atmospheric particulate matter from São Paulo, Brazil.
Mutation research 2008;652(1):72-80.
2008: Marie Stiborová; Eva Frei; Volker M Arlt; Heinz H Schmeiser
Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.
Mutation research 2008;658(1-2):55-67.
2007: Michael G Cornelius; Heinz H Schmeiser
RNA analysis by MEKC with LIF detection.
Electrophoresis 2007;28(21):3901-7.
2007: Volker M Arlt; Marie Stiborová; Jochen Vom Brocke; Maria L Simões; Graham M Lord; Joelle L Nortier; Monica Hollstein; David H Phillips; Heinz H Schmeiser
Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
Carcinogenesis 2007;28(11):2253-61.
2007: Christian A Bieler; Michael G Cornelius; Marie Stiborova; Volker M Arlt; Manfred Wiessler; David H Phillips; Heinz H Schmeiser
Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats.
Carcinogenesis 2007;28(5):1117-21.
2007: Volker M Arlt; Eva Frei; Heinz H Schmeiser
ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006.
Mutagenesis 2007;22(1):83-8.
2006: Marie Stiborová; Václav Martínek; Heinz H Schmeiser; Eva Frei
Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.
Neuro endocrinology letters 2006;27 Suppl 2():35-9.
2006: Helena Dracínska; Markéta Miksanová; Martina Svobodová; Stanislav Smrcek; Eva Frei; Heinz H Schmeiser; Marie Stiborová
Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.
Neuro endocrinology letters 2006;27 Suppl 2():9-13.
2006: Jochen Vom Brocke; Heinz H Schmeiser; Manuela Reinbold; Monica Hollstein
MEF immortalization to investigate the ins and outs of mutagenesis.
Carcinogenesis 2006;27(11):2141-7.
2006: N Feldmeyer; Heinz H Schmeiser; Karl-Rudolf Muehlbauer; Djeda Belharazem; Y Knyazev; T Nedelko; Monica Hollstein
Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences.
Mutation research 2006;608(2):163-8.
2006: Marie Stiborová; Helena Dracínská; Jana Hájková; Pavla Kaderábková; Eva Frei; Heinz H Schmeiser; Pavel Soucek; David H Phillips; Volker M Arlt
The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1398-405.
2006: Marie Stiborova; Martina Rupertova; Heinz H Schmeiser; Eva Frei
Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2006;150(1):13-23.
2006: Volker M Arlt; Heinz H Schmeiser; Martin R Osborne; Masanobu Kawanishi; Takaharu Kanno; Takashi Yagi; David H Phillips; Takeji Takamura-Enya
Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine.
International journal of cancer. Journal international du cancer 2006;118(9):2139-46.
2006: Volker M Arlt; Colin Henderson; C Roland Wolf; Heinz H Schmeiser; David H Phillips; Marie Stiborova
Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.
Cancer letters 2006;234(2):220-31.
2005: Marie Stiborová; Volker M Arlt; Colin Henderson; C Roland Wolf; Eva Frei; Heinz H Schmeiser; David H Phillips
Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):191-7.
2005: Marie Stiborová; Bruno Sopko; Petr Hodek; Eva Frei; Heinz H Schmeiser; Jirí Hudecek
The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.
Cancer letters 2005;229(2):193-204.
2005: Christian A Bieler; Michael G Cornelius; Reinhold Klein; Volker M Arlt; Manfred Wiessler; David H Phillips; Heinz H Schmeiser
DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats.
International journal of cancer. Journal international du cancer 2005;116(6):833-8.
2005: Marie Stiborová; Markéta Miksanová; Miroslav Sulc; Helena Rýdlová; Heinz H Schmeiser; Eva Frei
Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine.
International journal of cancer. Journal international du cancer 2005;116(5):667-78.
2005: Martin R Osborne; Volker M Arlt; Christian Kliem; William E Hull; Amin Mirza; Christian A Bieler; Heinz H Schmeiser; David H Phillips
Synthesis, characterization, and 32p-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-nitrobenzanthrone.
Chemical research in toxicology 2005;18(6):1056-70.
2005: Michael G Cornelius; Christian G C T Wörth; Hans-Christian Kliem; Manfred Wiessler; Heinz H Schmeiser
Detection and separation of nucleoside-5'-monophosphates of DNA by conjugation with the fluorescent dye BODIPY and capillary electrophoresis with laser-induced fluorescence detection.
Electrophoresis 2005;26(13):2591-8.
2005: Volker M Arlt; Marie Stiborova; Colin Henderson; Martin R Osborne; Christian A Bieler; Eva Frei; Vaclav Martinek; Bruno Sopko; C Roland Wolf; Heinz H Schmeiser; David H Phillips
Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.
Cancer research 2005;65(7):2644-52.
2005: Zhipei Liu; Karl-Rudolf Muehlbauer; Heinz H Schmeiser; Manfred Hergenhahn; Djeda Belharazem; Monica Hollstein
p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors.
Cancer research 2005;65(7):2583-7.
2005: Marie Stiborová; Eva Frei; Petr Hodek; Manfred Wiessler; Heinz H Schmeiser
Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
International journal of cancer. Journal international du cancer 2005;113(2):189-97.
2004: Volker M Arlt; Véronique Alunni-Perret; Gérald Quatrehomme; Patrick Ohayon; Laetitia Albano; Hacène Gaïd; Jean-Francois Michiels; Alain Meyrier; Elisabeth Cassuto; Manfred Wiessler; Heinz H Schmeiser; Jean-Pierre Cosyns
Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancer.
International journal of cancer. Journal international du cancer 2004;111(6):977-80.
2004: Volker M Arlt; Alan Hewer; Bernd L Sorg; Heinz H Schmeiser; David H Phillips; Marie Stiborova
3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.
Chemical research in toxicology 2004;17(8):1092-101.
2004: Torsten Haack; Gernot Boche; Christian Kliem; Manfred Wiessler; Dieter Albert; Heinz H Schmeiser
Synthesis, characterization, and 32P-postlabeling of N-(deoxyguanosin)-4-aminobiphenyl 3'-phosphate adducts.
Chemical research in toxicology 2004;17(6):776-84.
2004: Markéta Miksanová; Miroslav Sulc; Helena Rýdlová; Heinz H Schmeiser; Eva Frei; Marie Stiborová
Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.
Chemical research in toxicology 2004;17(5):663-71.
2004: Marie Stiborová; Markéta Miksanová; Stanislav Smrcek; Christian A Bieler; Andrea Breuer; Karl A Klokow; Heinz H Schmeiser; Eva Frei
Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans.
Carcinogenesis 2004;25(5):833-40.
2004: Graham M Lord; Monica Hollstein; Volker M Arlt; Candice Roufosse; Charles D Pusey; Terry Cook; Heinz H Schmeiser
DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;43(4):e11-7.
2004: Zhipei Liu; Manfred Hergenhahn; Heinz H Schmeiser; Gerald N Wogan; Amanda Hong; Monica Hollstein
Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2963-8.
2004: Evelyn Lamy; Fekadu Kassie; Richard Gminski; Heinz H Schmeiser; Volker Mersch-Sundermann
3-Nitrobenzanthrone (3-NBA) induced micronucleus formation and DNA damage in human hepatoma (HepG2) cells.
Toxicology letters 2004;146(2):103-9.
2004: Volker M Arlt; Li Zhan; Heinz H Schmeiser; Masamitsu Honma; Makoto Hayashi; David H Phillips; Takayoshi Suzuki
DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse.
Environmental and molecular mutagenesis 2004;43(3):186-95.
2003: Christian A Bieler; Volker M Arlt; Manfred Wiessler; Heinz H Schmeiser
DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone in V79 cells expressing human cytochrome P450 enzymes.
Cancer letters 2003;200(1):9-18.
2003: Marie Stiborová; Eva Frei; Bruno Sopko; Klára Sopková; Vladimira Marková; Martina Lanková; Tereza Kumstýrová; Manfred Wiessler; Heinz H Schmeiser
Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.
Carcinogenesis 2003;24(10):1695-703.
2003: Volker M Arlt; Hansruedi Glatt; Eva Muckel; Ulrike Pabel; Bernd L Sorg; Albrecht Seidel; Heinz Frank; Heinz H Schmeiser; David H Phillips
Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
International journal of cancer. Journal international du cancer 2003;105(5):583-92.
2003: Volker M Arlt; Marie Stiborova; Alan Hewer; Heinz H Schmeiser; David H Phillips
Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.
Cancer research 2003;63(11):2752-61.
2003: Joëlle L Nortier; Heinz H Schmeiser; Marie-Carmen Muniz Martinez; Volker M Arlt; Catherine Vervaet; Christian Hubert Garbar; Philippe Daelemans; Jean-Louis Vanherweghem
Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(2):426-8.
2003: Volker M Arlt; Bernd L Sorg; Martin Osborne; Alan Hewer; Albrecht Seidel; Heinz H Schmeiser; David H Phillips
DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats.
Biochemical and biophysical research communications 2003;300(1):107-14.
2002: Volker M Arlt; Hansruedi Glatt; Eva Muckel; Ulrike Pabel; Bernd L Sorg; Heinz H Schmeiser; David H Phillips
Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase.
Carcinogenesis 2002;23(11):1937-45.
2002: Volker M Arlt; Dusan Ferluga; Marie Stiborova; Annie Pfohl-Leszkowicz; Mato Vukelic; Stjepan Ceovic; Heinz H Schmeiser; Jean-Pierre Cosyns
Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?
International journal of cancer. Journal international du cancer 2002;101(5):500-2.
2002: Volker M Arlt; Marie Stiborova; Heinz H Schmeiser
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
Mutagenesis 2002;17(4):265-77.
2002: Marie Stiborová; Eva Frei; Bruno Sopko; Manfred Wiessler; Heinz H Schmeiser
Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.
Carcinogenesis 2002;23(4):617-25.
2002: Marie Stiborová; Markéta Miksanová; Vladimír Havlícek; Heinz H Schmeiser; Eva Frei
Mechanism of peroxidase-mediated oxidation of carcinogenic o-anisidine and its binding to DNA.
Mutation research 2002;500(1-2):49-66.
2001: Marie Stiborová; M Hájek; Eva Frei; Heinz H Schmeiser
Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH : cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy.
General physiology and biophysics 2001;20(4):375-92.
2001: Graham M Lord; T Cook; Volker M Arlt; Heinz H Schmeiser; G Williams; Charles D Pusey
Urothelial malignant disease and Chinese herbal nephropathy.
Lancet 2001;358(9292):1515-6.
2001: Gaëlle Gillerot; M Jadoul; Volker M Arlt; C van Ypersele de Strihou; Heinz H Schmeiser; P P But; Christian A Bieler; Jean-Pierre Cosyns
Aristolochic acid nephropathy in a Chinese patient: time to abandon the term "Chinese herbs nephropathy"?
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(5):E26.
2001: Catherine Lebeau; Volker M Arlt; Heinz H Schmeiser; Alain Boom; P J Verroust; Olivier Devuyst; Renaud Beauwens
Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells.
Kidney international 2001;60(4):1332-42.
2001: Marie Stiborová; Heinz H Schmeiser; Andrea Breuer; Eva Frei
Evidence for activation of carcinogenic o-anisidine by prostaglandin H synthase: 32P-postlabelling analysis of DNA adduct formation.
General physiology and biophysics 2001;20(3):267-79.
2001: Marie Stiborová; Eva Frei; Manfred Wiessler; Heinz H Schmeiser
Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2.
Chemical research in toxicology 2001;14(8):1128-37.
2001: Volker M Arlt; Christian A Bieler; Walter Mier; Manfred Wiessler; Heinz H Schmeiser
DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling.
International journal of cancer. Journal international du cancer 2001;93(3):450-4.
2001: Volker M Arlt; Annie Pfohl-Leszkowicz; Jean-Pierre Cosyns; Heinz H Schmeiser
Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy.
Mutation research 2001;494(1-2):143-50.
2001: Marie Stiborová; Eva Frei; Andrea Breuer; Manfred Wiessler; Heinz H Schmeiser
Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation.
Mutation research 2001;493(1-2):149-60.
2001: Volker M Arlt; Heinz H Schmeiser; G P Pfeifer
Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.
Carcinogenesis 2001;22(1):133-40.
2000: Joëlle L Nortier; Marie-Carmen Muniz Martinez; Heinz H Schmeiser; Volker M Arlt; Christian A Bieler; M Petein; Michel Depierreux; Luc De Pauw; Daniel Abramowicz; Pierre Vereerstraeten; Jean-Louis Vanherweghem
Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
The New England journal of medicine 2000;342(23):1686-92.
2000: Marie Stiborová; Heinz H Schmeiser; E Frei
Oxidation of xenobiotics by plant microsomes, a reconstituted cytochrome P450 system and peroxidase: a comparative study.
Phytochemistry 2000;54(4):353-62.
2000: Volker M Arlt; Manfred Wiessler; Heinz H Schmeiser
Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene.
Carcinogenesis 2000;21(2):235-42.
1999: Marie Stiborová; Heinz H Schmeiser; Eva Frei
Prostaglandin H synthase-medicated oxidation and binding to DNA of a detoxication metabolite of carcinogenic Sudan I, 1-(phenylazo)-2,6-dihydroxynaphthalene.
Cancer letters 1999;146(1):53-60.
1999: Sebastian Kevekordes; Volker Mersch-Sundermann; C M Burghaus; J Spielberger; Heinz H Schmeiser; Volker M Arlt; Hartmut Dunkelberg
SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
Mutation research 1999;445(1):81-91.
1999: Marie Stiborová; Eva Frei; Andrea Breuer; Christian A Bieler; Heinz H Schmeiser
Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(4-5):421-7.
1999: Marie Stiborová; Heinz H Schmeiser; Manfred Wiessler; Eva Frei
Direct evidence for the formation of deoxyribonucleotide adducts from carcinogenic N-nitroso-N-methylaniline revealed by the 32P-postlabeling technique.
Cancer letters 1999;138(1-2):61-6.
1999: Christian A Bieler; Manfred Wiessler; L Erdinger; H Suzuki; T Enya; Heinz H Schmeiser
DNA adduct formation from the mutagenic air pollutant 3-nitrobenzanthrone.
Mutation research 1999;439(2):307-11.
1998: Jean-Pierre Cosyns; Rose-Marie Goebbels; V Liberton; Heinz H Schmeiser; Christian A Bieler; A M Bernard
Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats.
Archives of toxicology 1998;72(11):738-43.
1997: Marie Stiborová; Hana Hansíková; Heinz H Schmeiser; Eva Frei
An investigation of the metabolism of N-nitrosodimethylamine and N-nitrosomethylaniline by horseradish peroxidase in vitro.
General physiology and biophysics 1997;16(3):285-97.
1997: Christian A Bieler; Marie Stiborova; Manfred Wiessler; Jean-Pierre Cosyns; C van Ypersele de Strihou; Heinz H Schmeiser
32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy.
Carcinogenesis 1997;18(5):1063-7.
1997: Heinz H Schmeiser; Eva Frei; Manfred Wiessler; Marie Stiborova
Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases.
Carcinogenesis 1997;18(5):1055-62.
1996: Heinz H Schmeiser; Christian A Bieler; Manfred Wiessler; C van Ypersele de Strihou; Jean-Pierre Cosyns
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy.
Cancer research 1996;56(9):2025-8.
1995: T H Broschard; Manfred Wiessler; Heinz H Schmeiser
Effect of site-specifically located aristolochic acid DNA adducts on in vitro DNA synthesis by human DNA polymerase alpha.
Cancer letters 1995;98(1):47-56.
1995: Marie Stiborová; Befekadu Asfaw; Eva Frei; Heinz H Schmeiser; Manfred Wiessler
Benzenediazonium ion derived from Sudan I forms an 8-(phenylazo)guanine adduct in DNA.
Chemical research in toxicology 1995;8(4):489-98.
1994: T H Broschard; Manfred Wiessler; Claus-W von der Lieth; Heinz H Schmeiser
Translesional synthesis on DNA templates containing site-specifically placed deoxyadenosine and deoxyguanosine adducts formed by the plant carcinogen aristolochic acid.
Carcinogenesis 1994;15(10):2331-40.
1994: Marie Stiborová; R C Fernando; Heinz H Schmeiser; Eva Frei; Wolfgang Pfau; Manfred Wiessler
Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures.
Carcinogenesis 1994;15(6):1187-92.
1993: P M Baumgart; H C Kliem; J Gottfried-Anacker; M Wiessler; Heinz H Schmeiser
Site-specific mutagenesis induced by single O6-alkylguanines (O6-n-propyl, O6-n-butyl, O6-n-octyl) in vivo.
Nucleic acids research 1993;21(16):3755-60.
1993: D Hadjiolov; R C Fernando; Heinz H Schmeiser; Manfred Wiessler; N Hadjiolov; G Pirajnov
Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats.
Carcinogenesis 1993;14(3):407-10.
1993: Marie Stiborová; Eva Frei; Heinz H Schmeiser; Manfred Wiessler; J Hradec
Detoxication products of the carcinogenic azodye Sudan I (solvent yellow 14) bind to nucleic acids after activation by peroxidase.
Cancer letters 1993;68(1):43-7.
1993: Heinz H Schmeiser; A Castonguay; Manfred Wiessler
32P-postlabelling analysis of DNA-adducts formed by 4-(N-carbethoxy-N-nitrosamino)-(3-pyridyl)-1-butanone and 4-oxo-4-(3-pyridyl)- butanal.
IARC scientific publications 1993;(124):207-10.
1993: R C Fernando; Heinz H Schmeiser; H R Scherf; Manfred Wiessler
Formation and persistence of specific purine DNA adducts by 32P-postlabelling in target and non-target organs of rats treated with aristolochic acid I.
IARC scientific publications 1993;(124):167-71.
1992: R C Fernando; Heinz H Schmeiser; W Nicklas; Manfred Wiessler
Detection and quantitation of dG-AAI and dA-AAI adducts by 32P-postlabeling methods in urothelium and exfoliated cells in urine of rats treated with aristolochic acid I.
Carcinogenesis 1992;13(10):1835-9.
1992: Marie Stiborová; Eva Frei; Heinz H Schmeiser
Comparison of cytochrome P-450- and peroxidase-mediated activations of carcinogenic azo dyes and N-nitrosamines.
General physiology and biophysics 1992;11(5):489-98.
1992: Marie Stiborová; Eva Frei; Heinz H Schmeiser; Manfred Wiessler; J Hradec
Formation and 32P-postlabeling of DNA and tRNA adducts derived from peroxidative activation of carcinogenic azo dye N,N-dimethyl-4-aminoazobenzene.
Carcinogenesis 1992;13(9):1657-62.
1992: Marie Stiborová; Eva Frei; Heinz H Schmeiser; Manfred Wiessler
32P-postlabeling analysis of adducts formed from 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) with DNA and homopolydeoxyribonucleotides.
Carcinogenesis 1992;13(7):1221-5.
1992: Marie Stiborová; Eva Frei; Heinz H Schmeiser; Manfred Wiessler; Pavel Anzenbacher
Peroxidase oxidizes N-nitrosomethylaniline to ultimate carcinogens(s) binding to DNA and transfer RNA in vitro.
Cancer letters 1992;63(1):53-9.
1992: Martin R Berger; P Yanapirut; M Reinhardt; T Klenner; H R Scherf; Heinz H Schmeiser; Hansjörg Eibl
Antitumor activity of alkylphosphocholines and analogues in methylnitrosourea-induced rat mammary carcinomas.
Progress in experimental tumor research 1992;34():98-115.
1991: Wolfgang Pfau; Heinz H Schmeiser; Manfred Wiessler
N6-adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen.
Chemical research in toxicology 1991;4(5):581-6.
1991: Heinz H Schmeiser; H R Scherf; Manfred Wiessler
Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice.
Cancer letters 1991;59(2):139-43.
1991: Marie Stiborová; Eva Frei; Heinz H Schmeiser; Pavel Anzenbacher
The role of peroxidases in the activation of chemical carcinogens.
Drug metabolism and drug interactions 1991;9(3-4):177-90.
1990: Marie Stiborová; Eva Frei; Heinz H Schmeiser; Manfred Wiessler; J Hradec
Mechanism of formation and 32P-postlabeling of DNA adducts derived from peroxidative activation of carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I).
Carcinogenesis 1990;11(10):1843-8.
1990: Wolfgang Pfau; Heinz H Schmeiser; Manfred Wiessler
32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II.
Carcinogenesis 1990;11(9):1627-33.
1990: Heinz H Schmeiser; J W Janssen; J Lyons; H R Scherf; Wolfgang Pfau; Albrecht Buchmann; C R Bartram; Manfred Wiessler
Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.
Cancer research 1990;50(17):5464-9.
1990: Wolfgang Pfau; Heinz H Schmeiser; Manfred Wiessler
Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA.
Carcinogenesis 1990;11(2):313-9.
1988: Heinz H Schmeiser; K B Schoepe; Manfred Wiessler
DNA adduct formation of aristolochic acid I and II in vitro and in vivo.
Carcinogenesis 1988;9(2):297-303.