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Ian Blagbrough

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Publications

TOP 3
Abdelkader A Metwally; Ian S Blagbrough; Judith M Mantell
Quantitative silencing of EGFP reporter gene by self-assembled siRNA lipoplexes of LinOS and cholesterol.
Manal S Elmasry; Ian S Blagbrough; Michael G Rowan; Hanaa M Saleh; Afaf Aboul Kheir; Philip J Rogers
Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.
Ian S Blagbrough; Abdelkader A Metwally; Andrew J Geall
Measurement of polyamine pKa values.

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All Publications

2012: Abdelkader A Metwally; Ian S Blagbrough; Judith M Mantell
Quantitative silencing of EGFP reporter gene by self-assembled siRNA lipoplexes of LinOS and cholesterol.
Molecular pharmaceutics 2012;9(11):3384-95.
2011: Manal S Elmasry; Ian S Blagbrough; Michael G Rowan; Hanaa M Saleh; Afaf Aboul Kheir; Philip J Rogers
Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.
Journal of pharmaceutical and biomedical analysis 2011;54(4):646-52.
2011: Ian S Blagbrough; Abdelkader A Metwally; Andrew J Geall
Measurement of polyamine pKa values.
Methods in molecular biology (Clifton, N.J.) 2011;720():493-503.
2010: Ian S Blagbrough; Soad A L Bayoumi; Michael G Rowan; John R Beeching
Cassava: an appraisal of its phytochemistry and its biotechnological prospects.
Phytochemistry 2010;71(17-18):1940-51.
2010: Soad A L Bayoumi; Michael G Rowan; John R Beeching; Ian S Blagbrough
Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots.
Phytochemistry 2010;71(5-6):598-604.
2010: Hassan M Ghonaim; Shi Li; Ian S Blagbrough
N1,N12-Diacyl spermines: SAR studies on non-viral lipopolyamine vectors for plasmid DNA and siRNA formulation.
Pharmaceutical research 2010;27(1):17-29.
2009: Moustafa K Soltan; Hassan Ghonaim; Mohamed El Sadek; M Abou Kull; Lubna Abd El-aziz; Ian S Blagbrough
Design and synthesis of N4,N9-disubstituted spermines for non-viral siRNA delivery--structure-activity relationship studies of siFection efficiency versus toxicity.
Pharmaceutical research 2009;26(2):286-95.
2008: Soad A L Bayoumi; Michael G Rowan; Ian S Blagbrough; John R Beeching
Biosynthesis of scopoletin and scopolin in cassava roots during post-harvest physiological deterioration: the E-Z-isomerisation stage.
Phytochemistry 2008;69(17):2928-36.
2008: Hassan Ghonaim; Osama A A Ahmed; Charareh Pourzand; Ian S Blagbrough
Varying the chain length in N4,N9-diacyl spermines: non-viral lipopolyamine vectors for efficient plasmid DNA formulation.
Molecular pharmaceutics 2008;5(6):1111-21.
2008: Hanan S M Farghaly; Ian S Blagbrough; David A Medina-Tato; Malcolm Watson
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism.
Molecular pharmacology 2008;73(5):1530-7.
2006: Noppadon Adjimatera; Teresa Kral; Martin Hof; Ian S Blagbrough
Lipopolyamine-mediated single nanoparticle formation of calf thymus DNA analyzed by fluorescence correlation spectroscopy.
Pharmaceutical research 2006;23(7):1564-73.
2006: Debra McLaggan; Noppadon Adjimatera; Kristina Sepcić; Marcel Jaspars; David J MacEwan; Ian S Blagbrough; Roderick H Scott
Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA.
BMC biotechnology 2006;6():6.
2006: Osama A A Ahmed; Charareh Pourzand; Ian S Blagbrough
Varying the unsaturation in N4,N9-dioctadecanoyl spermines: nonviral lipopolyamine vectors for more efficient plasmid DNA formulation.
Pharmaceutical research 2006;23(1):31-40.
2005: Osama A A Ahmed; Noppadon Adjimatera; Charareh Pourzand; Ian S Blagbrough
N4,N9-dioleoyl spermine is a novel nonviral lipopolyamine vector for plasmid DNA formulation.
Pharmaceutical research 2005;22(6):972-80.
2003: Ian S Blagbrough; Andrew Geall; A P Neal
Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy.
Biochemical Society transactions 2003;31(2):397-406.
2002: Jean-Guy Delcros; Sophie Tomasi; Simon Carrington; Bénédicte Martin; Jacques Renault; Ian S Blagbrough; Philippe Uriac
Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.
Journal of medicinal chemistry 2002;45(23):5098-111.
2002: Andrew Geall; Dima Al-Hadithi; Ian S Blagbrough
Efficient calf thymus DNA condensation upon binding with novel bile acid polyamine amides.
Bioconjugate chemistry 2002;13(3):481-90.
2001: RJ Lind; DJ Hardick; Ian S Blagbrough; BV Potter; Adrian J Wolstenholme; AR Davies; M S Clough; F G Earley; Stuart E Reynolds; Susan Wonnacott
[3H]-Methyllycaconitine: a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors.
Insect biochemistry and molecular biology 2001;31(6-7):533-42.
2000: Ian S Blagbrough; Andrew Geall; S A David
Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide.
Bioorganic & medicinal chemistry letters 2000;10(17):1959-62.
2000: Andrew Geall; Ian S Blagbrough
Rapid and sensitive ethidium bromide fluorescence quenching assay of polyamine conjugate-DNA interactions for the analysis of lipoplex formation in gene therapy.
Journal of pharmaceutical and biomedical analysis 2000;22(5):849-59.
2000: Andrew Geall; R J Taylor; M E Earll; M A Eaton; Ian S Blagbrough
Synthesis of cholesteryl polyamine carbamates: pK(a) studies and condensation of calf thymus DNA.
Bioconjugate chemistry 2000;11(3):314-26.
1999: Andrew Geall; M A Eaton; T Baker; C Catterall; Ian S Blagbrough
The regiochemical distribution of positive charges along cholesterol polyamine carbamates plays significant roles in modulating DNA binding affinity and lipofection.
FEBS letters 1999;459(3):337-42.
1999: Paul Whiteaker; AR Davies; Michael J Marks; Ian S Blagbrough; BV Potter; Adrian J Wolstenholme; Allan C Collins; Susan Wonnacott
An autoradiographic study of the distribution of binding sites for the novel alpha7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain.
The European journal of neuroscience 1999;11(8):2689-96.
1999: AR Davies; DJ Hardick; Ian S Blagbrough; BV Potter; Adrian J Wolstenholme; Susan Wonnacott
Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors.
Neuropharmacology 1999;38(5):679-90.
1998: Roderick H Scott; NM Thatcher; A Ayar; S J Mitchell; J Pollock; M T Gibson; Ian Duce; E Moya; Ian S Blagbrough
Extracellular or intracellular application of argiotoxin-636 has inhibitory actions on membrane excitability and voltage-activated currents in cultured rat sensory neurones.
Neuropharmacology 1998;37(12):1563-78.
1997: AR Davies; DJ Hardick; Ian S Blagbrough; BV Potter; Adrian J Wolstenholme; Susan Wonnacott
Structure-activity studies of bicyclic and tricyclic analogues of methyllycaconitine.
Biochemical Society transactions 1997;25(3):545S.
1997: Mohammad Fatehi; Edward G Rowan; Alan L Harvey; E Moya; Ian S Blagbrough
Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals.
Neuropharmacology 1997;36(2):185-94.
1996: D J Hardick; Ian S Blagbrough; G Cooper; B V Potter; T Critchley; Susan Wonnacott
Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding.
Journal of medicinal chemistry 1996;39(24):4860-6.
1996: T M Norris; E Moya; Ian S Blagbrough; Michael E Adams
Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3.
Molecular pharmacology 1996;50(4):939-46.
1996: P A Coates; Ian S Blagbrough; M G Rowan; D P Pearson; T Lewis; B V Potter
Preliminary synthetic studies of methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist: rapid syntheses of AE-bicyclic analogues.
The Journal of pharmacy and pharmacology 1996;48(2):210-3.
1996: E Moya; Ian S Blagbrough
Efficient syntheses of polyamine and polyamine amide voltage-sensitive calcium channel blockers: FTX-3.3 and sFTX-3.3.
The Journal of pharmacy and pharmacology 1996;48(2):179-82.
1996: J R Dupere; E Moya; Ian S Blagbrough; Maria M Usowicz
Differential inhibition of Ca2+ channels in mature rat cerebellar Purkinje cells by sFTX-3.3 and FTX-3.3.
Neuropharmacology 1996;35(1):1-11.
1995: P A Coates; Ian S Blagbrough; T Lewis; B V Potter; M G Rowan
An HPLC assay for the norditerpenoid alkaloid methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist.
Journal of pharmaceutical and biomedical analysis 1995;13(12):1541-44.
1995: A Rodger; S Taylor; G Adlam; Ian S Blagbrough; Ian S Haworth
Multiple DNA binding modes of anthracene-9-carbonyl-N1-spermine.
Bioorganic & medicinal chemistry 1995;3(6):861-72.
1995: D J Hardick; G Cooper; T Scott-Ward; Ian S Blagbrough; B V Potter; Susan Wonnacott
Conversion of the sodium channel activator aconitine into a potent alpha 7-selective nicotinic ligand.
FEBS letters 1995;365(1):79-82.
1995: J Screen; E Moya; Ian S Blagbrough; Anthony W Smith
Iron uptake in Pseudomonas aeruginosa mediated by N-(2,3-dihydroxybenzoyl)-L-serine and 2,3-dihydroxybenzoic acid.
FEMS microbiology letters 1995;127(1-2):145-9.
1994: A Rodger; Ian S Blagbrough; G Adlam; M L Carpenter
DNA binding of a spermine derivative: spectroscopic study of anthracene-9-carbonyl-N1-spermine with poly[d(G-C).(d(G-C)] and poly[d(A-T).d(A-T)].
Biopolymers 1994;34(12):1583-93.
1994: Ian S Blagbrough; E Moya; S Taylor
Polyamines and polyamine amides from wasps and spiders.
Biochemical Society transactions 1994;22(4):888-93.