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Marc Schmidt-Supprian

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Katharina U Vogel; Sebastian C Warth; Wolfgang Wurst; Jessica Zöller; Arianna Bertossi; Helmut Blum; Stephanie L Edelmann; Arie Geerlof; Klaus Heger; Mathias Heikenwälder; Gitta A Heinz; Kai P Hoefig; Katharina M Jeltsch; Elisabeth Kremmer; Claudia Lohs; Frauke Neff; Dirk Repsilber; Joel Schick; Marc Schmidt-Supprian; Vigo Heissmeyer
Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation.
Gloria Lutzny; Robert Oostendorp; Christian Peschel; Jan Dürig; Alexander Egle; Andrew J Finch; Claudia Haferlach; Ludger Klein-Hitpass; Thomas Kocher; Alexander Kohlmann; Toni Kuhnt; Benedikt Lampl; Michael Leitges; Martina Rudelius; Jürgen Ruland; Yvonne Schäfer; Marc Schmidt-Supprian; Susanne Schnittger; Marc Seifert; Michaela Wagner; Stefan Wanninger; Nadja Zaborsky; Ingo Ringshausen
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Martin Pal; Marc Schmidt-Supprian; Gabriele Spohn; Claudia M Wunderlich; Hella S Brönneke; F Thomas Wunderlich
Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice.

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All Publications

2013: Katharina U Vogel; Sebastian C Warth; Wolfgang Wurst; Jessica Zöller; Arianna Bertossi; Helmut Blum; Stephanie L Edelmann; Arie Geerlof; Klaus Heger; Mathias Heikenwälder; Gitta A Heinz; Kai P Hoefig; Katharina M Jeltsch; Elisabeth Kremmer; Claudia Lohs; Frauke Neff; Dirk Repsilber; Joel Schick; Marc Schmidt-Supprian; Vigo Heissmeyer
Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation.
Immunity 2013;38(4):655-68.
2013: Gloria Lutzny; Robert Oostendorp; Christian Peschel; Jan Dürig; Alexander Egle; Andrew J Finch; Claudia Haferlach; Ludger Klein-Hitpass; Thomas Kocher; Alexander Kohlmann; Toni Kuhnt; Benedikt Lampl; Michael Leitges; Martina Rudelius; Jürgen Ruland; Yvonne Schäfer; Marc Schmidt-Supprian; Susanne Schnittger; Marc Seifert; Michaela Wagner; Stefan Wanninger; Nadja Zaborsky; Ingo Ringshausen
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Cancer cell 2013;23(1):77-92.
2013: Martin Pal; Marc Schmidt-Supprian; Gabriele Spohn; Claudia M Wunderlich; Hella S Brönneke; F Thomas Wunderlich
Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice.
PloS one 2013;8(1):e54247.
2012: Yuanyuan Chu; Laura Glockner; Daniel Krappmann; Ramin Massoumi; Valeria Soberon; Geert Van Loo; Rudi Beyaert; Marc Schmidt-Supprian
A20 and CYLD do not share significant overlapping functions during B cell development and activation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(9):4437-43.
2012: Sally J Deeb; Rochelle C J D'Souza; Jürgen Cox; Marc Schmidt-Supprian; Matthias Mann
Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles.
Molecular & cellular proteomics : MCP 2012;11(5):77-89.
2012: Lin Liu; Basma Abdel Motaal; Marc Schmidt-Supprian; Nicola L B Pohl
Multigram synthesis of isobutyl-β-C-galactoside as a substitute of isopropylthiogalactoside for exogenous gene induction in mammalian cells.
The Journal of organic chemistry 2012;77(3):1539-46.
2011: Natalie Krahmer; Susanne Lingrell; Matthias Mann; Heather W Newman; Marc Schmidt-Supprian; Dennis E Vance; Robert V Farese; Yi Guo; Klaus Heger; Maximiliane Hilger; Florian Wilfling; Tobias C Walther
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
Cell metabolism 2011;14(4):504-15.
2011: Mourad Matmati; Patrick Matthys; Manolis Pasparakis; Marc Schmidt-Supprian; Steven Staelens; Mozes Sze; Lars Vereecke; Eveline Verheugen; Conor Mc Guire; Rudi Beyaert; Louis Boon; Yuanyuan Chu; Dirk Elewaut; Lies Geboes; Peggy Jacques; Mirjam Kool; Bart N Lambrecht; Els Louagie; Jonathan Maelfait; Geert Van Loo
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Nature genetics 2011;43(9):908-12.
2011: Arianna Bertossi; Ludger Klein; Maciej Lech; Frauke Neff; Martin Pal; Paola Sansonetti; Martin Aichinger; Hans-Joachim Anders; F Thomas Wunderlich; Marc Schmidt-Supprian
Loss of Roquin induces early death and immune deregulation but not autoimmunity.
The Journal of experimental medicine 2011;208(9):1749-56.
2011: Janin Hofmann; Florian Mair; Marc Schmidt-Supprian; Melanie Greter; Burkhard Becher
NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses.
The Journal of experimental medicine 2011;208(9):1917-29.
2011: Andreas Birbach; David Eisenbarth; Nicolas Kozakowski; Eva Ladenhauf; Marc Schmidt-Supprian; Johannes A Schmid
Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model.
Neoplasia (New York, N.Y.) 2011;13(8):692-703.
2011: Kamyar Hadian; Wolfgang Beisker; Scarlett Dornauer; Richard A Griesbach; Moritz Metlitzky; Daniel Nagel; Marc Schmidt-Supprian; Tim M Wanger; Daniel Krappmann
NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation.
The Journal of biological chemistry 2011;286(29):26107-17.
2011: Katerina Vlantis; Andy Wullaert; Klaus Rajewsky; Tania Roskams; Yoshiteru Sasaki; Marc Schmidt-Supprian; Manolis Pasparakis
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice.
The Journal of clinical investigation 2011;121(7):2781-93.
2011: Zohar Keren; Shulamit Naor; Shahar Nussbaum; Karin Golan; Tomer Itkin; Yoshiteru Sasaki; Marc Schmidt-Supprian; Tsvee Lapidot; Doron Melamed
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.
Blood 2011;117(11):3104-12.
2011: Yuanyuan Chu; J Christoph Vahl; Dilip Kumar; Klaus Heger; Arianna Bertossi; Edyta Wójtowicz; Valeria Soberon; Dominik Schenten; Brigitte Mack; Miriam Reutelshöfer; Rudi Beyaert; Kerstin Amann; Geert van Loo; Marc Schmidt-Supprian
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice.
Blood 2011;117(7):2227-36.
2011: Michael Green; Stefano Monti; Riccardo Dalla-Favera; Laura Pasqualucci; Nicole C Walsh; Marc Schmidt-Supprian; Jeffery L Kutok; Scott Rodig; Donna S Neuberg; Klaus Rajewsky; Todd R Golub; Frederick W Alt; Margaret A Shipp; John P Manis
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2873-8.
2010: Dinis Calado; Baochun Zhang; Lakshmi Srinivasan; Yoshiteru Sasaki; Jane Seagal; Christine Unitt; Scott Rodig; Jeffery Kutok; Alexander Tarakhovsky; Marc Schmidt-Supprian; Klaus Rajewsky
Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.
Cancer cell 2010;18(6):580-9.
2010: Lars Vereecke; Mozes Sze; Conor Mc Guire; Brecht Rogiers; Yuanyuan Chu; Marc Schmidt-Supprian; Manolis Pasparakis; Rudi Beyaert; Geert Van Loo
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.
The Journal of experimental medicine 2010;207(7):1513-23.
2010: Hiroshi Ashida; Minsoo Kim; Marc Schmidt-Supprian; Averil Ma; Ogawa Michinaga; Chihiro Sasakawa
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response.
Nature cell biology 2010;12(1):66-73; sup pp 1-9.
2009: Emmanuel Derudder; Emily J Cadera; J Christoph Vahl; Jing Wang; Casey J Fox; Shan Zha; Geert van Loo; Manolis Pasparakis; Mark S Schlissel; Marc Schmidt-Supprian; Klaus Rajewsky
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Nature immunology 2009;10(6):647-54.
2008: Kevin L Otipoby; Yoshiteru Sasaki; Marc Schmidt-Supprian; Alina Patke; Ralph Gareus; Manolis Pasparakis; Alexander Tarakhovsky; Klaus Rajewsky
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12435-8.
2008: Yoshiteru Sasaki; Dinis Calado; Emmanuel Derudder; Baochun Zhang; Yuri Shimizu; Fabienne Mackay; Shin-ichi Nishikawa; Klaus Rajewsky; Marc Schmidt-Supprian
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10883-8.
2008: F Thomas Wunderlich; Tom Luedde; Stephan Singer; Marc Schmidt-Supprian; Julia Baumgartl; Peter Schirmacher; Manolis Pasparakis; Jens C Brüning
Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1297-302.
2007: Marc Schmidt-Supprian; F Thomas Wunderlich; Klaus Rajewsky
Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination.
Transgenic research 2007;16(5):657-60.
2007: Marc Schmidt-Supprian; Klaus Rajewsky
Vagaries of conditional gene targeting.
Nature immunology 2007;8(7):665-8.
2007: Bernhard Greve; Robert Weissert; Nada Hamdi; Estelle Bettelli; Raymond A Sobel; Anthony J Coyle; Vijay K Kuchroo; Klaus Rajewsky; Marc Schmidt-Supprian
I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):179-85.
2007: Huifei Liu; Marc Schmidt-Supprian; Yujiang Shi; Elias Hobeika; Natasha Barteneva; Hassan Jumaa; Roberta Pelanda; Michael Reth; Jane Skok; Klaus Rajewsky; Yang Shi
Yin Yang 1 is a critical regulator of B-cell development.
Genes & development 2007;21(10):1179-89.
2007: Yinon Ben-Neriah; Marc Schmidt-Supprian
Epithelial NF-kappaB maintains host gut microflora homeostasis.
Nature immunology 2007;8(5):479-81.
2007: To-Ha Thai; Dinis Calado; Stefano Casola; K Mark Ansel; Changchun Xiao; Yingzi Xue; Andrew Murphy; David Frendewey; David M Valenzuela; Jeffery L Kutok; Marc Schmidt-Supprian; Nikolaus Rajewsky; George D Yancopoulos; Anjana Rao; Klaus Rajewsky
Regulation of the germinal center response by microRNA-155.
Science (New York, N.Y.) 2007;316(5824):604-8.
2007: Alla V Tsytsykova; James V Falvo; Marc Schmidt-Supprian; Gilles Courtois; Dimitris Thanos; Anne E Goldfeld
Post-induction, stimulus-specific regulation of tumor necrosis factor mRNA expression.
The Journal of biological chemistry 2007;282(16):11629-38.
2007: Yoshiteru Sasaki; Marc Schmidt-Supprian; Emmanuel Derudder; Klaus Rajewsky
Role of NFkappaB signaling in normal and malignant B cell development.
Advances in experimental medicine and biology 2007;596():149-54.
2006: Geert Van Loo; Rossana De Lorenzi; Hauke Schmidt; Marion Huth; Alexander Mildner; Marc Schmidt-Supprian; Hans Lassmann; Marco R Prinz; Manolis Pasparakis
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice.
Nature immunology 2006;7(9):954-61.
2006: Elmar Wegener; Andrea Oeckinghaus; Nikoletta Papadopoulou; Liron Lavitas; Marc Schmidt-Supprian; Uta Ferch; Tak W Mak; Jürgen Ruland; Vigo Heissmeyer; Daniel Krappmann
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Molecular cell 2006;23(1):13-23.
2006: Yoshiteru Sasaki; Emmanuel Derudder; Elias Hobeika; Roberta Pelanda; Michael Reth; Klaus Rajewsky; Marc Schmidt-Supprian
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.
Immunity 2006;24(6):729-39.
2006: Manolis Pasparakis; Tom Luedde; Marc Schmidt-Supprian
Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.
Cell death and differentiation 2006;13(5):861-72.
2006: Arianna Nenci; Marion Huth; Alfred Funteh; Marc Schmidt-Supprian; Wilhelm Bloch; Daniel Metzger; Pierre Chambon; Klaus Rajewsky; Thomas Krieg; Ingo Haase; Manolis Pasparakis
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.
Human molecular genetics 2006;15(4):531-42.
2005: Tom Luedde; Ulrike Assmus; Torsten Wüstefeld; Andreas Meyer zu Vilsendorf; Tania Roskams; Marc Schmidt-Supprian; Klaus Rajewsky; David A Brenner; Michael P Manns; Manolis Pasparakis; Christian Trautwein
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
The Journal of clinical investigation 2005;115(4):849-59.
2004: Yoshiteru Sasaki; Stefano Casola; Jeffery L Kutok; Klaus Rajewsky; Marc Schmidt-Supprian
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2245-52.
2004: Marc Schmidt-Supprian; Jane Tian; Hongbin Ji; Cox Terhorst; Atul K Bhan; Ethan P Grant; Manolis Pasparakis; Stefano Casola; Anthony J Coyle; Klaus Rajewsky
I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1612-9.
2004: Marc Schmidt-Supprian; Jane Tian; Ethan P Grant; Manolis Pasparakis; Rene Maehr; Huib Ovaa; Hidde L Ploegh; Anthony J Coyle; Klaus Rajewsky
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4566-71.
2003: Christian Schmidt; Bailu Peng; Zhongkui Li; Guido M Sclabas; Shuichi Fujioka; Jiangong Niu; Marc Schmidt-Supprian; Douglas B Evans; James L Abbruzzese; Paul J Chiao
Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation.
Molecular cell 2003;12(5):1287-300.
2003: Marc Schmidt-Supprian; Gilles Courtois; Jane Tian; Anthony J Coyle; Alain Israël; Klaus Rajewsky; Manolis Pasparakis
Mature T cells depend on signaling through the IKK complex.
Immunity 2003;19(3):377-89.
2002: Manolis Pasparakis; Marc Schmidt-Supprian; Klaus Rajewsky
IkappaB kinase signaling is essential for maintenance of mature B cells.
The Journal of experimental medicine 2002;196(6):743-52.
2002: Manolis Pasparakis; Gilles Courtois; Martin Hafner; Marc Schmidt-Supprian; Arianna Nenci; Atiye Toksoy; Monika Krampert; Matthias Goebeler; Reinhard Gillitzer; Alain Israel; Thomas Krieg; Klaus Rajewsky; Ingo Haase
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.
Nature 2002;417(6891):861-6.
2000: Marc Schmidt-Supprian; Wilhelm Bloch; Gilles Courtois; Klaus Addicks; Alain Israël; Klaus Rajewsky; Manolis Pasparakis
NEMO/IKK gamma-deficient mice model incontinentia pigmenti.
Molecular cell 2000;5(6):981-92.