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Helmut Schmidt

Research Profile

Chemicals & Drugs

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Pain
Miosis

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Christian Brenneis; Ovidiu Coste; Kai Altenrath; Carlo Angioni; Helmut Schmidt; Claus-Dieter Schuh; Dong Dong Zhang; Marina Henke; Andreas Weigert; Bernhard Brüne; Barry Rubin; Rolf Nusing; Klaus Scholich; Gerd Geisslinger
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Susanne Schiffmann; Simone Ziebell; Jessica Sandner; Kerstin Birod; Klaus Deckmann; Daniela Hartmann; Sina Rode; Helmut Schmidt; Carlo Angioni; Gerd Geisslinger; Sabine Grösch
Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide.
Ralf Frederik Claas; Michael ter Braak; Bianca Hegen; Verena Hardel; Carlo Angioni; Helmut Schmidt; Karl H Jakobs; Paul P Van Veldhoven; Dagmar Meyer zu Heringdorf
Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.

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All Publications

2011: Christian Brenneis; Ovidiu Coste; Kai Altenrath; Carlo Angioni; Helmut Schmidt; Claus-Dieter Schuh; Dong Dong Zhang; Marina Henke; Andreas Weigert; Bernhard Brüne; Barry Rubin; Rolf Nusing; Klaus Scholich; Gerd Geisslinger
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
The Journal of biological chemistry 2011;286(3):2331-42.
2010: Susanne Schiffmann; Simone Ziebell; Jessica Sandner; Kerstin Birod; Klaus Deckmann; Daniela Hartmann; Sina Rode; Helmut Schmidt; Carlo Angioni; Gerd Geisslinger; Sabine Grösch
Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide.
Biochemical pharmacology 2010;80(11):1632-40.
2010: Ralf Frederik Claas; Michael ter Braak; Bianca Hegen; Verena Hardel; Carlo Angioni; Helmut Schmidt; Karl H Jakobs; Paul P Van Veldhoven; Dagmar Meyer zu Heringdorf
Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.
Cellular signalling 2010;22(3):476-83.
2010: Bruno Georg Oertel; L Felden; P V Tran; M H Bradshaw; M S Angst; Helmut Schmidt; S Johnson; J J Greer; Gerd Geisslinger; M A Varney; Jörn Lötsch
Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia.
Clinical pharmacology and therapeutics 2010;87(2):204-11.
2010: Philipp Bishay; Helmut Schmidt; Claudiu Marian; Annett Häussler; Nina Wijnvoord; Simone Ziebell; Julia Metzner; Marco Koch; Thekla Myrczek; Ingo Bechmann; Rohini Kuner; Michael Costigan; Faramarz Dehghani; Gerd Geisslinger; Irmgard Tegeder
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.
PloS one 2010;5(5):e10628.
2009: Kosta Altis; Achim Schmidtko; Carlo Angioni; Karina Kuczka; Helmut Schmidt; Gerd Geisslinger; Jörn Lötsch; Irmgard Tegeder
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.
Pain 2009;147(1-3):116-21.
2009: Harald Farnik; Juliane El-Duweik; Christoph Welsch; Christoph Sarrazin; Jörn Lötsch; Stefan Zeuzem; Gerd Geisslinger; Helmut Schmidt
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(31):4001-6.
2009: Jörn Lötsch; Maren Rohrbacher; Helmut Schmidt; Alexandra Doehring; Jürgen Brockmöller; Gerd Geisslinger
Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?
Pain 2009;144(1-2):119-24.
2009: Susanne Schiffmann; Jessica Sandner; Kerstin Birod; Ivonne Wobst; Carlo Angioni; Eugen Ruckhäberle; Manfred Kaufmann; Hanns Ackermann; Jörn Lötsch; Helmut Schmidt; Gerd Geisslinger; Sabine Grösch
Ceramide synthases and ceramide levels are increased in breast cancer tissue.
Carcinogenesis 2009;30(5):745-52.
2009: Voahanginirina Randriamboavonjy; Klaus Badenhoop; Helmut Schmidt; Gerd Geisslinger; Beate Fisslthaler; Ingrid Fleming
The S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes.
Basic research in cardiology 2009;104(3):333-40.
2008: Ovidiu Coste; Christian Brenneis; Bona Linke; Sandra C Pierre; Christian Maeurer; Wiebke Becker; Helmut Schmidt; Wei Gao; Gerd Geisslinger; Klaus Scholich
Sphingosine 1-phosphate modulates spinal nociceptive processing.
The Journal of biological chemistry 2008;283(47):32442-51.
2008: Irmgard Tegeder; Jan Adolph; Helmut Schmidt; Clifford J Woolf; Gerd Geisslinger; Jörn Lötsch
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.
European journal of pain (London, England) 2008;12(8):1069-77.
2008: Dana Schiefelbein; Oliver Seitz; Itamar Goren; Jan Philipp Dissmann; Helmut Schmidt; Malte Bachmann; Robert Sader; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank
Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.
Molecular pharmacology 2008;74(4):952-63.
2008: Ovidiu Coste; Sandra Pierre; Claudiu Marian; Christian Brenneis; Carlo Angioni; Helmut Schmidt; Laura Popp; Gerd Geisslinger; Klaus Scholich
Antinociceptive activity of the S1P-receptor agonist FTY720.
Journal of cellular and molecular medicine 2008;12(3):995-1004.
2008: Dana Schiefelbein; Itamar Goren; Beate Fisslthaler; Helmut Schmidt; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank
Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.
The Journal of biological chemistry 2008;283(22):15479-90.
2008: Charles Mills; Milan Makwana; Adam Wallace; Susanna C Benn; Helmut Schmidt; Irmgard Tegeder; Michael Costigan; Robert H Brown; Gennadij Raivich; Clifford J Woolf
Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats.
The European journal of neuroscience 2008;27(4):937-46.
2007: Helmut Schmidt; Jörn Lötsch
Pharmacokinetic-pharmacodynamic modeling of the miotic effects of dihydrocodeine in humans.
European journal of clinical pharmacology 2007;63(11):1045-54.
2007: Andreas Weigert; Nico Tzieply; Andreas von Knethen; Axel M Johann; Helmut Schmidt; Gerd Geisslinger; Bernhard Brüne
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.
Molecular biology of the cell 2007;18(10):3810-9.
2007: Sandra Ulrich; Andrea Huwiler; Stefan Loitsch; Helmut Schmidt; Jürgen M Stein
De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity.
Biochemical pharmacology 2007;74(2):281-9.
2007: Bruno Georg Oertel; Andreas Schneider; Maren Rohrbacher; Helmut Schmidt; Irmgard Tegeder; Gerd Geisslinger; Jörn Lötsch
The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans.
Clinical pharmacology and therapeutics 2007;81(1):59-68.
2007: Martin Michaelis; Ruth Michaelis; Tatyana Suhan; Helmut Schmidt; Annisuddin Mohamed; Hans Wilhelm Doerr; Jindrich Cinatl
Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):81-7.
2006: Helmut Schmidt; Ronald Schmidt; Gerd Geisslinger
LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples.
Prostaglandins & other lipid mediators 2006;81(3-4):162-70.
2006: Irmgard Tegeder; Michael Costigan; Robert S Griffin; Andrea Abele; Inna Belfer; Helmut Schmidt; Corina Ehnert; Jemiel Nejim; Claudiu Marian; Joachim Scholz; Tianxia Wu; Andrew J Allchorne; Luda Diatchenko; Alexander M Binshtok; David Goldman; Jan Adolph; Swetha Sama; Steven J Atlas; William A Carlezon; Aram Parsegian; Jörn Lötsch; Roger B Fillingim; William Maixner; Gerd Geisslinger; Mitchell B Max; Clifford J Woolf
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
Nature medicine 2006;12(11):1269-77.
2006: Andreas Weigert; Axel M Johann; Andreas von Knethen; Helmut Schmidt; Gerd Geisslinger; Bernhard Brüne
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.
Blood 2006;108(5):1635-42.
2006: Jörn Lötsch; Carsten Skarke; Johannes Wieting; Bruno Georg Oertel; Helmut Schmidt; Jürgen Brockmöller; Gerd Geisslinger
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.
Clinical pharmacology and therapeutics 2006;79(1):72-89.
2006: Jörn Lötsch; Carsten Skarke; Helmut Schmidt; Maren Rohrbacher; ute hofmann; Matthias Schwab; Gerd Geisslinger
Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites.
Clinical pharmacology and therapeutics 2006;79(1):35-48.
2004: Carsten Skarke; Michael Langer; Marwan Jarrar; Helmut Schmidt; Gerd Geisslinger; Jörn Lötsch
Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.
Anesthesiology 2004;101(6):1394-9.
2004: Ellen Niederberger; Christine Manderscheid; Sabine Grösch; Helmut Schmidt; Corina Ehnert; Gerd Geisslinger
Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells.
Biochemical pharmacology 2004;68(2):341-50.
2004: Helmut Schmidt; Barry G Woodcock; Gerd Geisslinger
Benefit-risk assessment of rofecoxib in the treatment of osteoarthritis.
Drug safety : an international journal of medical toxicology and drug experience 2004;27(3):185-96.
2003: Lutz Bräutigam; Maic Seegel; Irmgard Tegeder; Helmut Schmidt; Silke Meier; Maurizio Podda; Roland Kaufmann; Marcella Grundmann-Kollmann; Gerd Geisslinger
Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(2):223-9.
2003: Carsten Skarke; Marwan Jarrar; Helmut Schmidt; Gerold F Kauert; Michael Langer; Gerd Geisslinger; Jörn Lötsch
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.
Pharmacogenetics 2003;13(11):651-60.
2003: Carsten Skarke; Marwan Jarrar; Katharina Erb; Helmut Schmidt; Gerd Geisslinger; Jörn Lötsch
Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine.
Clinical pharmacology and therapeutics 2003;74(4):303-11.
2003: Carsten Skarke; Helmut Schmidt; Gerd Geisslinger; Jutta Darimont; Jörn Lötsch
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome.
British journal of clinical pharmacology 2003;56(2):228-31.
2003: Irmgard Tegeder; Silke Meier; Martin Burian; Helmut Schmidt; Gerd Geisslinger; Jörn Lötsch
Peripheral opioid analgesia in experimental human pain models.
Brain : a journal of neurology 2003;126(Pt 5):1092-102.
2003: Irmgard Tegeder; Sabine Grösch; Achim Schmidtko; Annett Häussler; Helmut Schmidt; Ellen Niederberger; Klaus Scholich; Gerd Geisslinger
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
Cancer research 2003;63(8):1846-52.
2003: Helmut Schmidt; Stefan Viktor Vormfelde; Monika Walchner-Bonjean; Klaus Klinder; Stefan Freudenthaler; Christoph H Gleiter; Ursula Gundert-Remy; Gisela Skopp; Rolf Aderjan; Uwe Fuhr
The role of active metabolites in dihydrocodeine effects.
International journal of clinical pharmacology and therapeutics 2003;41(3):95-106.
2003: Carsten Skarke; Jutta Darimont; Helmut Schmidt; Gerd Geisslinger; Jörn Lötsch
Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers.
Clinical pharmacology and therapeutics 2003;73(1):107-21.
2002: Jörn Lötsch; Rodolfo Schmidt; Gregor Vetter; Helmut Schmidt; Ellen Niederberger; Gerd Geisslinger; Irmgard Tegeder
Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein.
Journal of neurochemistry 2002;83(2):241-8.
2002: Jörn Lötsch; Rodolfo Schmidt; Gregor Vetter; Helmut Schmidt; Carsten Skarke; Ellen Niederberger; Gerd Geisslinger; Irmgard Tegeder
The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats.
Neuroscience letters 2002;329(2):145-8.
2002: Helmut Schmidt; Stefan Viktor Vormfelde; Klaus Klinder; Ursula Gundert-Remy; Christoph H Gleiter; Gisela Skopp; Rolf Aderjan; Uwe Fuhr
Affinities of dihydrocodeine and its metabolites to opioid receptors.
Pharmacology & toxicology 2002;91(2):57-63.
2002: Jörn Lötsch; Carsten Skarke; Helmut Schmidt; Jürgen Liefhold; Gerd Geisslinger
Pharmacokinetic modeling to predict morphine and morphine-6-glucuronide plasma concentrations in healthy young volunteers.
Clinical pharmacology and therapeutics 2002;72(2):151-62.
2002: Jörn Lötsch; Carsten Skarke; Sabine Grösch; Jutta Darimont; Helmut Schmidt; Gerd Geisslinger
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.
Pharmacogenetics 2002;12(1):3-9.
2001: Jörn Lötsch; Carsten Skarke; Helmut Schmidt; Sabine Grösch; Gerd Geisslinger
The transfer half-life of morphine-6-glucuronide from plasma to effect site assessed by pupil size measurement in healthy volunteers.
Anesthesiology 2001;95(6):1329-38.
2001: Ellen Niederberger; Irmgard Tegeder; Gregor Vetter; Achim Schmidtko; Helmut Schmidt; C Euchenhofer; Lutz Bräutigam; Sabine Grösch; Gerd Geisslinger
Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1622-4.