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Werner Schmitz

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Publications

TOP 3
Viswanadham Duppatla; Maja Gjorgjevikj; Mathias Kottmair; Thomas D Mueller; Werner Schmitz; Walter Sebald
Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol.
Satyan Sharma; Rajaram Venkatesan; Prasenjit Bhaumik; Ernst Conzelmann; J Kalervo Hiltunen; André H Juffer; Werner Schmitz; Rik K Wierenga
The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations.
Gerhard Bringmann; Barbara Hertlein-Amslinger; Inga Kajahn; Michael Dreyer; Reto Brun; Heidrun Moll; August Stich; Karine Ndjoko Ioset; Werner Schmitz; Luu Hoang Ngoc
Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities.

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All Publications

2012: Viswanadham Duppatla; Maja Gjorgjevikj; Mathias Kottmair; Thomas D Mueller; Werner Schmitz; Walter Sebald
Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol.
Bioconjugate chemistry 2012;23(7):1396-405.
2012: Satyan Sharma; Rajaram Venkatesan; Prasenjit Bhaumik; Ernst Conzelmann; J Kalervo Hiltunen; André H Juffer; Werner Schmitz; Rik K Wierenga
The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations.
The journal of physical chemistry. B 2012;116(11):3619-29.
2011: Gerhard Bringmann; Barbara Hertlein-Amslinger; Inga Kajahn; Michael Dreyer; Reto Brun; Heidrun Moll; August Stich; Karine Ndjoko Ioset; Werner Schmitz; Luu Hoang Ngoc
Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities.
Phytochemistry 2011;72(1):89-93.
2010: Junli Hu; Viswanadham Duppatla; Stefan Harth; Werner Schmitz; Walter Sebald
Site-specific PEGylation of bone morphogenetic protein-2 cysteine analogues.
Bioconjugate chemistry 2010;21(10):1762-72.
2009: Lisa Polzien; Angela Baljuls; Ulrike E E Rennefahrt; Andreas Fischer; Werner Schmitz; René P Zahedi; Albert Sickmann; Renate Metz; Stefan Albert; Roland Benz; Mirko Hekman; Ulf R Rapp
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
The Journal of biological chemistry 2009;284(41):28004-20.
2009: Ilkka J Miinalainen; Werner Schmitz; Anne Huotari; Kaija J Autio; Raija Soininen; Emiel Ver Loren van Themaat; Myriam Baes; Karl-Heinz Herzig; Ernst Conzelmann; J Kalervo Hiltunen
Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.
PLoS genetics 2009;5(7):e1000543.
2009: Stella E Weidauer; Peter Schmieder; Monika Beerbaum; Werner Schmitz; Hartmut Oschkinat; Thomas D Mueller
NMR structure of the Wnt modulator protein Sclerostin.
Biochemical and biophysical research communications 2009;380(1):160-5.
2009: Kai Heinecke; Axel Seher; Werner Schmitz; Thomas D Mueller; Walter Sebald; Joachim Nickel
Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.
BMC biology 2009;7():59.
2008: Gitte Meriläinen; Werner Schmitz; Rik K Wierenga; Petri Kursula
The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme.
The FEBS journal 2008;275(24):6136-48.
2008: Angela Baljuls; Werner Schmitz; Thomas Mueller; René P Zahedi; Albert Sickmann; Mirko Hekman; Ulf R Rapp
Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.
The Journal of biological chemistry 2008;283(40):27239-54.
2007: Prasenjit Bhaumik; Werner Schmitz; Antti Hassinen; J Kalervo Hiltunen; Ernst Conzelmann; Rik K Wierenga
The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface.
Journal of molecular biology 2007;367(4):1145-61.
2006: Radim Vicik; Matthias Busemann; Christoph Gelhaus; Nikolaus Stiefl; Josef Scheiber; Werner Schmitz; Franziska Schulz; Milena Mladenovic; Bernd Engels; Joachim Grötzinger; Knut Baumann; Tanja Schirmeister
Aziridide-based inhibitors of cathepsin L: synthesis, inhibition activity, and docking studies.
ChemMedChem 2006;1(10):1126-41.
2005: Ulrich Kaeppler; Nikolaus Stiefl; Markus Schiller; Radim Vicik; Alexander Breuning; Werner Schmitz; Daniel Rupprecht; Carsten Schmuck; Knut Baumann; John Ziebuhr; Tanja Schirmeister
A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods.
Journal of medicinal chemistry 2005;48(22):6832-42.
2005: Kalle Savolainen; Prasenjit Bhaumik; Werner Schmitz; Tiina J Kotti; Ernst Conzelmann; Rik K Wierenga; J Kalervo Hiltunen
Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.
The Journal of biological chemistry 2005;280(13):12611-20.
2004: Kalle Savolainen; Tiina J Kotti; Werner Schmitz; Teuvo I Savolainen; Raija Sormunen; Mika Ilves; Seppo Vainio; Ernst Conzelmann; J Kalervo Hiltunen
A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.
Human molecular genetics 2004;13(9):955-65.
2003: Prasenjit Bhaumik; Petri Kursula; Ville Ratas; Ernst Conzelmann; J Kalervo Hiltunen; Werner Schmitz; Rik K Wierenga
Crystallization and preliminary X-ray diffraction studies of an alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 2):353-5.
2002: Dean Cuebas; Christopher Phillips; Werner Schmitz; Ernst Conzelmann; Dmitry K Novikov
The role of alpha-methylacyl-CoA racemase in bile acid synthesis.
The Biochemical journal 2002;363(Pt 3):801-7.
2001: Juha M Torkko; Kari T Koivuranta; I J Miinalainen; AI Yagi; Werner Schmitz; Alexander J Kastaniotis; Tomi T Airenne; Aner Gurvitz; KJ Hiltunen
Candida tropicalis Etr1p and Saccharomyces cerevisiae Ybr026p (Mrf1'p), 2-enoyl thioester reductases essential for mitochondrial respiratory competence.
Molecular and cellular biology 2001;21(18):6243-53.
2000: Tiina J Kotti; Kalle Savolainen; Heli M Helander; AI Yagi; Dmitry K Novikov; N Kalkkinen; Ernst Conzelmann; J Kalervo Hiltunen; Werner Schmitz
In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes.
The Journal of biological chemistry 2000;275(27):20887-95.
1999: Tiila-Riikka Kiema; CK Engel; Werner Schmitz; Sirpa A Filppula; Rik K Wierenga; J Kalervo Hiltunen
Mutagenic and enzymological studies of the hydratase and isomerase activities of 2-enoyl-CoA hydratase-1.
Biochemistry 1999;38(10):2991-9.
1997: Werner Schmitz; Heli M Helander; J Kalervo Hiltunen; Ernst Conzelmann
Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases.
The Biochemical journal 1997;326 ( Pt 3)():883-9.
1997: Werner Schmitz; Ernst Conzelmann
Stereochemistry of peroxisomal and mitochondrial beta-oxidation of alpha-methylacyl-CoAs.
European journal of biochemistry / FEBS 1997;244(2):434-40.
1997: Yong-Mei Qin; Matti Poutanen; Heli M Helander; Ari-Pekka Kvist; K M Siivari; Werner Schmitz; Ernst Conzelmann; U Hellman; J Kalervo Hiltunen
Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization.
The Biochemical journal 1997;321 ( Pt 1)():21-8.
1995: Werner Schmitz; C Albers; R Fingerhut; Ernst Conzelmann
Purification and characterization of an alpha-methylacyl-CoA racemase from human liver.
European journal of biochemistry / FEBS 1995;231(3):815-22.
1994: Werner Schmitz; R Fingerhut; Ernst Conzelmann
Purification and properties of an alpha-methylacyl-CoA racemase from rat liver.
European journal of biochemistry / FEBS 1994;222(2):313-23.
1994: R Fingerhut; Werner Schmitz; B Garavaglia; Heinz Reichmann; Ernst Conzelmann
Impaired degradation of phytanic acid in cells from patients with mitochondriopathies: evidence for the involvement of ETF and the respiratory chain in phytanic acid alpha-oxidation.
Journal of inherited metabolic disease 1994;17(5):527-32.
1993: R Fingerhut; Werner Schmitz; Ernst Conzelmann
Accumulation of phytanic acid alpha-oxidation intermediates in Zellweger fibroblasts.
Journal of inherited metabolic disease 1993;16(3):591-4.