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SM Schnittman

Research Profile

Living Beings

HIV-1
HIV

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HIV Seropositivity

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Publications

TOP 3
M T Niu; J Bethel; M Holodniy; HC Standiford; SM Schnittman
Zidovudine treatment in patients with primary (acute) human immunodeficiency virus type 1 infection: a randomized, double-blind, placebo-controlled trial. DATRI 002 Study Group. Division of AIDS Treatment Research Initiative.
DL Mayers; J Bethel; Mark A Wainberg; O Weislow; SM Schnittman
Human immunodeficiency virus proviral DNA from peripheral blood and lymph nodes demonstrates concordant resistance mutations to zidovudine (codon 215) and didanosine (codon 74). Division of AIDS Treatment Research Initiative 003 Study Group.
A L Landay; J Bethel; SM Schnittman
Phenotypic variability of lymphocyte populations in peripheral blood and lymph nodes from HIV-infected individuals and the impact of antiretroviral therapy. DATRI 003 Study Group. Division of AIDS Treatment Research Initiative.

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All Publications

1998: M T Niu; J Bethel; M Holodniy; HC Standiford; SM Schnittman
Zidovudine treatment in patients with primary (acute) human immunodeficiency virus type 1 infection: a randomized, double-blind, placebo-controlled trial. DATRI 002 Study Group. Division of AIDS Treatment Research Initiative.
The Journal of infectious diseases 1998;178(1):80-91.
1998: DL Mayers; J Bethel; Mark A Wainberg; O Weislow; SM Schnittman
Human immunodeficiency virus proviral DNA from peripheral blood and lymph nodes demonstrates concordant resistance mutations to zidovudine (codon 215) and didanosine (codon 74). Division of AIDS Treatment Research Initiative 003 Study Group.
The Journal of infectious diseases 1998;177(6):1730-3.
1998: A L Landay; J Bethel; SM Schnittman
Phenotypic variability of lymphocyte populations in peripheral blood and lymph nodes from HIV-infected individuals and the impact of antiretroviral therapy. DATRI 003 Study Group. Division of AIDS Treatment Research Initiative.
AIDS research and human retroviruses 1998;14(5):445-51.
1997: SM Schnittman; L Fox
Preliminary evidence for partial restoration of immune function in HIV type 1 infection with potent antiretroviral therapies: clues from the Fourth Conference on Retroviruses and Opportunistic Diseases.
AIDS research and human retroviruses 1997;13(10):815-8.
1996: SM Schnittman; P F Pierce
Potential role of lamivudine (3TC) in the clearance of chronic hepatitis B virus infection in a patient coinfected with human immunodeficiency virus type.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1996;23(3):638-9.
1996: OJ Cohen; Giuseppe Pantaleo; Mark Holodniy; CH Fox; Jan M Orenstein; SM Schnittman; M Niu; C Graziosi; George Pavlakis; J Lalezari; J A Bartlett; R T Steigbigel; Jonathan A Cohn; Richard M Novak; D McMahon; John Bilello; Anthony Fauci
Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.
The Journal of infectious diseases 1996;173(4):849-56.
1995: OJ Cohen; Giuseppe Pantaleo; Mark Holodniy; SM Schnittman; M Niu; C Graziosi; George Pavlakis; J Lalezari; J A Bartlett; R T Steigbigel
Decreased human immunodeficiency virus type 1 plasma viremia during antiretroviral therapy reflects downregulation of viral replication in lymphoid tissue.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6017-21.
1994: SM Schnittman; S Vogel; Michael Baseler; H Clifford Lane; Richard Davey
A phase I study of interferon-alpha 2b in combination with interleukin-2 in patients with human immunodeficiency virus infection.
The Journal of infectious diseases 1994;169(5):981-9.
1994: Andrea De Maria; S Colombini; SM Schnittman; Lorenzo Moretta
CD8+ cytolytic T lymphocytes become infected in vitro in the process of killing HIV-1-infected target cells.
European journal of immunology 1994;24(3):531-6.
1994: SM Schnittman; Anthony Fauci
Human immunodeficiency virus and acquired immunodeficiency syndrome: an update.
Advances in internal medicine 1994;39():305-55.
1993: M T Niu; D S Stein; SM Schnittman
Treatment trials for primary human immunodeficiency virus type 1 infection.
The Journal of infectious diseases 1993;168(6):1601-2.
1993: M T Niu; D S Stein; SM Schnittman
Primary human immunodeficiency virus type 1 infection: review of pathogenesis and early treatment intervention in humans and animal retrovirus infections.
The Journal of infectious diseases 1993;168(6):1490-501.
1993: D S Stein; J G Timpone; Jeremy David Gradon; J M Kagan; SM Schnittman
Immune-based therapeutics: scientific rationale and the promising approaches to the treatment of the human immunodeficiency virus-infected individual.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993;17(4):749-71.
1993: Carla Pettinelli; SM Schnittman
Treatment research priorities for human immunodeficiency virus infection.
Infectious agents and disease 1993;2(5):291-303.
1993: M T Niu; J A Jermano; P Reichelderfer; SM Schnittman
Summary of the National Institutes of Health workshop on primary human immunodeficiency virus type 1 infection.
AIDS research and human retroviruses 1993;9(9):913-24.
1992: S K Stanley; S W Kessler; J S Justement; SM Schnittman; J J Greenhouse; C C Brown; L Musongela; K Musey; B Kapita; Anthony Fauci
CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):689-97.
1992: Jeremy David Gradon; J G Timpone; SM Schnittman
Emergence of unusual opportunistic pathogens in AIDS: a review.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1992;15(1):134-57.
1991: Giuseppe Pantaleo; C Graziosi; Luca Butini; P A Pizzo; SM Schnittman; D P Kotler; Anthony Fauci
Lymphoid organs function as major reservoirs for human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9838-42.
1991: SM Schnittman; K H Singer; J J Greenhouse; S K Stanley; LP Whichard; P T Le; Barton F Haynes; Anthony Fauci
Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2553-8.
1991: D C Kalter; J J Greenhouse; Jan M Orenstein; SM Schnittman; Howard Gendelman; M S Meltzer
Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3396-404.
1991: Anthony Fauci; SM Schnittman; G Poli; Scott Koenig; G Pantaleo
NIH conference. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection.
Annals of internal medicine 1991;114(8):678-93.
1991: Andrea De Maria; Giuseppe Pantaleo; SM Schnittman; J J Greenhouse; Michael Baseler; Jan M Orenstein; Anthony Fauci
Infection of CD8+ T lymphocytes with HIV. Requirement for interaction with infected CD4+ cells and induction of infectious virus from chronically infected CD8+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2220-6.
1991: SM Schnittman; J J Greenhouse; H Clifford Lane; P F Pierce; Anthony Fauci
Frequent detection of HIV-1-specific mRNAs in infected individuals suggests ongoing active viral expression in all stages of disease.
AIDS research and human retroviruses 1991;7(4):361-7.
1991: Giuseppe Pantaleo; Luca Butini; C Graziosi; G Poli; SM Schnittman; J J Greenhouse; John Gallin; Anthony Fauci
Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission.
The Journal of experimental medicine 1991;173(2):511-4.
1991: S K Stanley; SM Schnittman; J J Greenhouse; W C Hatch; William D Lyman; Jan M Orenstein; Anthony Fauci
Characterization of an early thymocyte cell line which is chronically infected with the human immunodeficiency virus.
Transactions of the Association of American Physicians 1991;104():248-57.
1990: SM Schnittman; S M Denning; J J Greenhouse; J S Justement; Michael Baseler; J Kurtzberg; Barton F Haynes; Anthony Fauci
Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7727-31.
1990: SM Schnittman; J J Greenhouse; M C Psallidopoulos; Michael Baseler; N P Salzman; Anthony Fauci; H Clifford Lane
Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease.
Annals of internal medicine 1990;113(6):438-43.
1990: SM Schnittman; H Clifford Lane; J Greenhouse; J S Justement; Michael Baseler; Anthony Fauci
Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6058-62.
1990: F E Massari; G Poli; SM Schnittman; M C Psallidopoulos; Victoria Davey; Anthony Fauci
In vivo T lymphocyte origin of macrophage-tropic strains of HIV. Role of monocytes during in vitro isolation and in vivo infection.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4628-32.
1990: SM Schnittman; S M Denning; J J Greenhouse; J S Justement; Michael Baseler; Barton F Haynes; Anthony Fauci
Evidence for susceptibility of intrathymic T cell precursors to human immunodeficiency virus infection: a mechanism for T4 (CD4) lymphocyte depletion.
Transactions of the Association of American Physicians 1990;103():96-101.
1989: M C Psallidopoulos; SM Schnittman; L M Thompson; Michael Baseler; Anthony Fauci; H Clifford Lane; N P Salzman
Integrated proviral human immunodeficiency virus type 1 is present in CD4+ peripheral blood lymphocytes in healthy seropositive individuals.
Journal of virology 1989;63(11):4626-31.
1989: SM Schnittman; M C Psallidopoulos; H Clifford Lane; L Thompson; Michael Baseler; F Massari; C H Fox; N P Salzman; Anthony Fauci
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.
Science (New York, N.Y.) 1989;245(4915):305-8.
1989: G Poli; F E Massari; SM Schnittman; M C Psallidopoulos; Victoria Davey; H Clifford Lane; Anthony Fauci
Efficient macrophage isolation of human immunodeficiency virus from peripheral blood leukocytes from healthy seropositive individuals: implications for cell tropism.
Transactions of the Association of American Physicians 1989;102():110-6.
1988: SM Schnittman; H Clifford Lane; J Roth; A Burrows; Thomas M Folks; John Kehrl; Scott Koenig; P Berman; Anthony Fauci
Characterization of GP120 binding to CD4 and an assay that measures ability of sera to inhibit this binding.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4181-6.
1988: SM Schnittman; H Clifford Lane; Frank G Witebsky; L L Gosey; M D Hoggan; Anthony Fauci
Host defense against Mycobacterium-avium complex.
Journal of clinical immunology 1988;8(4):234-43.
1988: Thomas M Folks; J Justement; Audrey L Kinter; SM Schnittman; Jan M Orenstein; G Poli; Anthony Fauci
Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1117-22.