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Louis Schofield

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Victoria Ryg-Cornejo; Louis Schofield; Rachel J Lundie; Catherine Q Nie; Nicholas J Bernard; Brendan S Crabb; Krystal J Evans; Diana Hansen
NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection.
Danika L Hill; Danny W Wilson; Amandine B Carmagnac; Alan F Cowman; Emily M Eriksson; Diana Hansen; Louis Schofield
Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites.
Nicolas Senn; Peter Siba; Danielle I Stanisic; Nandao Tarongka; Peter Zimmerman; John J Aponte; Céline Barnadas; James G Beeson; Jonah Iga; Serej Ley; Doris Manong; Patricia Rarau; John C Reeder; Leanne Robinson; Stephen J Rogerson; Anna Rosanas-Urgell; Mary Salib; Louis Schofield; Ivo Mueller
Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial.

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2013: Victoria Ryg-Cornejo; Louis Schofield; Rachel J Lundie; Catherine Q Nie; Nicholas J Bernard; Brendan S Crabb; Krystal J Evans; Diana Hansen
NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection.
Immunobiology 2013;218(2):263-71.
2012: Danika L Hill; Danny W Wilson; Amandine B Carmagnac; Alan F Cowman; Emily M Eriksson; Diana Hansen; Louis Schofield
Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites.
PloS one 2012;7(12):e51692.
2012: Nicolas Senn; Peter Siba; Danielle I Stanisic; Nandao Tarongka; Peter Zimmerman; John J Aponte; Céline Barnadas; James G Beeson; Jonah Iga; Serej Ley; Doris Manong; Patricia Rarau; John C Reeder; Leanne Robinson; Stephen J Rogerson; Anna Rosanas-Urgell; Mary Salib; Louis Schofield; Ivo Mueller
Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial.
PLoS medicine 2012;9(3):e1001195.
2010: Wei Shi; Carolyn A de Graaf; Sarah A Kinkel; Ariel H Achtman; Tracey Baldwin; Louis Schofield; Hamish S Scott; Douglas J Hilton; Gordon K Smyth
Estimating the proportion of microarray probes expressed in an RNA sample.
Nucleic acids research 2010;38(7):2168-76.
2009: Leanne J Robinson; Marthe C D'Ombrain; Danielle I Stanisic; Jack Taraika; Nicholas Bernard; Jack S Richards; James G Beeson; Livingstone Tavul; Pascal Michon; Ivo Mueller; Louis Schofield
Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea.
Infection and immunity 2009;77(7):3033-43.
2009: Marthe C D'Ombrain; Leanne J Robinson; Ivo Mueller; Louis Schofield
Mechanisms underlying early interferon-gamma production in human Plasmodium falciparum malaria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(10):1482-3.
2009: Catherine Q Nie; Nicholas J Bernard; M Ursula Norman; Fiona H Amante; Rachel J Lundie; Brendan S Crabb; William R Heath; Christian R Engwerda; Michael J Hickey; Louis Schofield; Diana Hansen
IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection.
PLoS pathogens 2009;5(4):e1000369.
2008: Marthe C D'Ombrain; Leanne J Robinson; Danielle I Stanisic; Jack Taraika; Nicholas Bernard; Pascal Michon; Ivo Mueller; Louis Schofield
Association of early interferon-gamma production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(11):1380-7.
2008: Rachel J Lundie; Tania F de Koning-Ward; Gayle M Davey; Catherine Q Nie; Diana Hansen; Lei Shong Lau; Justine D Mintern; Gabrielle Belz; Louis Schofield; Francis R Carbone; Jose A Villadangos; Brendan S Crabb; William R Heath
Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14509-14.
2007: Irina Caminschi; Fatma Ahmet; Klaus Heger; Jason Brady; Stephen L Nutt; David Vremec; Suzanne Pietersz; Mireille Lahoud; Louis Schofield; Diana Hansen; Meredith O'Keeffe; Mark J Smyth; Sammy Bedoui; Gayle M Davey; Jose A Villadangos; William R Heath; Ken Shortman
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.
The Journal of experimental medicine 2007;204(11):2579-90.
2007: Marthe C D'Ombrain; Till S Voss; Alexander G Maier; J Andrew Pearce; Diana Hansen; Alan F Cowman; Louis Schofield
Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma.
Cell host & microbe 2007;2(2):130-8.
2007: Diana Hansen; Marthe C D'Ombrain; Louis Schofield
The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malaria.
Current opinion in immunology 2007;19(4):416-23.
2007: Marthe C D'Ombrain; Diana Hansen; Ken M Simpson; Louis Schofield
gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria.
European journal of immunology 2007;37(7):1864-73.
2007: Salenna R Elliott; Timothy P Spurck; Joelle M Dodin; Alexander G Maier; Till S Voss; Francisca Yosaatmadja; Paul D Payne; Geoffrey I McFadden; Alan F Cowman; Stephen J Rogerson; Louis Schofield; Graham V Brown
Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1.
Infection and immunity 2007;75(7):3621-32.
2007: Pascal Michon; Jennifer L Cole-Tobian; Elijah Dabod; Sonja Schoepflin; Jennifer Igu; Melinda Susapu; Nandao Tarongka; Peter Zimmerman; John C Reeder; James G Beeson; Louis Schofield; Christopher L King; Ivo Mueller
The risk of malarial infections and disease in Papua New Guinean children.
The American journal of tropical medicine and hygiene 2007;76(6):997-1008.
2007: Diana Hansen; Nicholas J Bernard; Catherine Q Nie; Louis Schofield
NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5779-88.
2007: Louis Schofield
Rational approaches to developing an anti-disease vaccine against malaria.
Microbes and infection / Institut Pasteur 2007;9(6):784-91.
2007: Catherine Q Nie; Nicholas J Bernard; Louis Schofield; Diana Hansen
CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis.
Infection and immunity 2007;75(5):2275-82.
2007: Louis Schofield
Intravascular infiltrates and organ-specific inflammation in malaria pathogenesis.
Immunology and cell biology 2007;85(2):130-7.
2006: Deborah Cromer; Krystal J Evans; Louis Schofield; Miles P Davenport
Preferential invasion of reticulocytes during late-stage Plasmodium berghei infection accounts for reduced circulating reticulocyte levels.
International journal for parasitology 2006;36(13):1389-97.
2006: Françoise Debierre-Grockiego; Louis Schofield; Nahid Azzouz; Jörg Schmidt; Cristiana Macedo; Michael A J Ferguson; Ralph T Schwarz
Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols.
Infection and immunity 2006;74(10):5487-96.
2006: Paul R Gilson; Thomas Nebl; Damjan Vukcevic; Robert L Moritz; Tobias Sargeant; Terence P Speed; Louis Schofield; Brendan S Crabb
Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum.
Molecular & cellular proteomics : MCP 2006;5(7):1286-99.
2006: Louis Schofield; Ivo Mueller
Clinical immunity to malaria.
Current molecular medicine 2006;6(2):205-21.
2006: Krystal J Evans; Diana Hansen; Nico van Rooijen; Lynn Buckingham; Louis Schofield
Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes.
Blood 2006;107(3):1192-9.
2005: Paul R Sanders; Paul R Gilson; Greg T Cantin; Doron C Greenbaum; Thomas Nebl; Daniel J Carucci; Malcolm J McConville; Louis Schofield; Anthony N Hodder; John R Yates; Brendan S Crabb
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.
The Journal of biological chemistry 2005;280(48):40169-76.
2005: Louis Schofield; Georges E Grau
Immunological processes in malaria pathogenesis.
Nature reviews. Immunology 2005;5(9):722-35.
2005: Diana Hansen; Krystal J Evans; Marthe C D'Ombrain; Nicholas J Bernard; Adrienne Clare Sexton; Lynn Buckingham; Anthony A Scalzo; Louis Schofield
The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA.
Infection and immunity 2005;73(4):2288-97.
2005: Thomas Nebl; Michael J de Veer; Louis Schofield
Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptors.
Parasitology 2005;130 Suppl():S45-62.
2004: Adrienne Clare Sexton; Rob Trygve Good; Diana Hansen; Marthe C D'Ombrain; Lynn Buckingham; Ken Simpson; Louis Schofield
Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malaria.
The Journal of infectious diseases 2004;189(7):1245-56.
2004: Diana Hansen; Louis Schofield
Regulation of immunity and pathogenesis in infectious diseases by CD1d-restricted NKT cells.
International journal for parasitology 2004;34(1):15-25.
2003: Michael J de Veer; Joan M Curtis; Tracey M Baldwin; Joseph A DiDonato; Adrienne Clare Sexton; Malcolm J McConville; Emanuela Handman; Louis Schofield
MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling.
European journal of immunology 2003;33(10):2822-31.
2003: Diana Hansen; Mary-Anne Siomos; Tania F de Koning-Ward; Lynn Buckingham; Brendan S Crabb; Louis Schofield
CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses.
European journal of immunology 2003;33(9):2588-98.
2003: Denise V R Bullen; Diana Hansen; Mary-Anne Siomos; Louis Schofield; Warren S Alexander; Emanuela Handman
The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA.
Parasite immunology 2003;25(3):113-8.
2003: Diana Hansen; Mary-Anne Siomos; Lynn Buckingham; Anthony A Scalzo; Louis Schofield
Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex.
Immunity 2003;18(3):391-402.
2002: Louis Schofield; Michael C Hewitt; Krystal Evans; Mary-Anne Siomos; Peter H Seeberger
Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria.
Nature 2002;418(6899):785-9.
2002: Mauro Delorenzi; Adrienne Clare Sexton; Hosam Shams-Eldin; Ralph T Schwarz; Terence P Speed; Louis Schofield
Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum.
Infection and immunity 2002;70(8):4510-22.
2002: Louis Schofield
Antidisease vaccines.
Chemical immunology 2002;80():322-42.
1999: SD Tachado; R Mazhari-Tabrizi; Louis Schofield
Specificity in signal transduction among glycosylphosphatidylinositols of Plasmodium falciparum, Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.
Parasite immunology 1999;21(12):609-17.
1999: S Berhe; Louis Schofield; Ralph T Schwarz; Peter Gerold
Conservation of structure among glycosylphosphatidylinositol toxins from different geographic isolates of Plasmodium falciparum.
Molecular and biochemical parasitology 1999;103(2):273-8.
1997: SD Tachado; Peter Gerold; R Schwarz; S Novakovic; M McConville; Louis Schofield
Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4022-7.
1997: CF Zinecker; Peter Gerold; Nahid Azzouz; Boris Striepen; A Schmidt; S Berhe; Jürgen Kimmel; M H Keddes; M J Blackman; Louis Schofield; Solabomi A Ogun; J B Damm; P A Melgers; M Koolen; G J Gerwig; J F Vliegenhardt; Jean-François Dubremetz; Anthony A Holder; Volker Eckert; Y Capdeville; SD Tachado; Ralph T Schwarz
Glycosyl-phosphatidylinositols in protozoa structure, biosynthesis and intracellular localisation.
Indian journal of biochemistry & biophysics 1997;34(1-2):105-9.
1996: Louis Schofield; SD Tachado
Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa.
Immunology and cell biology 1996;74(6):555-63.
1996: SD Tachado; Peter Gerold; Malcolm J McConville; T Baldwin; D Quilici; Ralph T Schwarz; Louis Schofield
Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1897-1907.
1996: Louis Schofield; S Novakovic; Peter Gerold; Ralph T Schwarz; Malcolm J McConville; SD Tachado
Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1886-96.
1996: Peter Gerold; Louis Schofield; M J Blackman; Anthony A Holder; Ralph T Schwarz
Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum.
Molecular and biochemical parasitology 1996;75(2):131-43.
1994: SD Tachado; Louis Schofield
Glycosylphosphatidylinositol toxin of Trypanosoma brucei regulates IL-1 alpha and TNF-alpha expression in macrophages by protein tyrosine kinase mediated signal transduction.
Biochemical and biophysical research communications 1994;205(2):984-91.
1994: Louis Schofield; Peter Gerold; Ralph T Schwarz; SD Tachado
Signal transduction in host cells mediated by glycosylphosphatidylinositols of the parasitic protozoa, or why do the parasitic protozoa have so many GPI molecules?
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):249-54.
1993: Louis Schofield; L Vivas; Fiona Hackett; Peter Gerold; Ralph T Schwarz; SD Tachado
Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.
Annals of tropical medicine and parasitology 1993;87(6):617-26.
1993: Louis Schofield; Fiona Hackett
Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.
The Journal of experimental medicine 1993;177(1):145-53.
1991: Louis Schofield
On the function of repetitive domains in protein antigens of Plasmodium and other eukaryotic parasites.
Parasitology today (Personal ed.) 1991;7(5):99-105.