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Dominique Schols

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Marijke M F Alen; Jan Balzarini; Kai Dallmeier; Johan Neyts; Dominique Schols
Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection.
Geoffrey Férir; Katrien O François; Anne Hänchen; Bart Hoorelbeke; Dana Huskens; Frank Dettner; Roderich D Süssmuth; Dominique Schols
Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120.
Geoffrey Férir; Dana Huskens; David M Markovitz; Kenneth Edward Palmer; Jan Balzarini; Daniel M Boudreaux; Michael D Swanson; Dominique Schols
Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains.

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2012: Marijke M F Alen; Jan Balzarini; Kai Dallmeier; Johan Neyts; Dominique Schols
Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection.
Antiviral research 2012;96(3):280-7.
2012: Geoffrey Férir; Katrien O François; Anne Hänchen; Bart Hoorelbeke; Dana Huskens; Frank Dettner; Roderich D Süssmuth; Dominique Schols
Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120.
Virology 2012;433(2):308-19.
2012: Geoffrey Férir; Dana Huskens; David M Markovitz; Kenneth Edward Palmer; Jan Balzarini; Daniel M Boudreaux; Michael D Swanson; Dominique Schols
Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains.
AIDS research and human retroviruses 2012;28(11):1513-23.
2012: Dana Huskens; Dominique Schols
Algal lectins as potential HIV microbicide candidates.
Marine drugs 2012;10(7):1476-97.
2012: Renee Mosi; Kim L Nelson; Ketan Patel; Zefferino Santucci; Dominique Schols; Renato T Skerlj; Rebecca S Y Wong; Virginia Anastassova; Gary J Bridger; Jennifer Cox; Marilyn C Darkes; Dana Huskens; Stefan R Idzan; Jean Labrecque; Gloria Lau; Simon P Fricker
The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.
Biochemical pharmacology 2012;83(4):472-9.
2012: Marijke M F Alen; Dominique Schols
Dengue virus entry as target for antiviral therapy.
Journal of tropical medicine 2012;2012():628475.
2012: Thomas W Bell; Violeta G Demillo; Dominique Schols; Kurt Vermeire
Improving potencies and properties of CD4 down-modulating CADA analogs.
Expert opinion on drug discovery 2012;7(1):39-48.
2012: Jan Balzarini; Dominique Schols
Combination of antiretroviral drugs as microbicides.
Current HIV research 2012;10(1):53-60.
2011: Geoffrey Férir; Kenneth Edward Palmer; Dominique Schols
Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C.
Virology 2011;417(2):253-8.
2011: Violeta G Demillo; Florian Goulinet-Mateo; Jessica Kim; Dominique Schols; Kurt Vermeire; Thomas W Bell
Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents.
Journal of medicinal chemistry 2011;54(16):5712-21.
2011: Miguel E Quiñones-Mateu; Dominique Schols
Virus-inhibitory peptide: a natural HIV entry inhibitor in search for a formal target in the viral genome.
AIDS (London, England) 2011;25(13):1663-4.
2011: Virginia Lozano; Marleen Renders; Ana San-Félix; Dominique Schols; Leire Aguado; Jan Balzarini; María-José Camarasa; Bart Hoorelbeke; María-Jesús Pérez-Pérez
Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.
Journal of medicinal chemistry 2011;54(15):5335-48.
2011: Joachim Brouwers; Carolien Grammen; Dominique Schols; Kurt Vermeire; Patrick Augustijns
Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir.
Antiviral research 2011;91(2):217-23.
2011: Geoffrey Férir; Kurt Vermeire; Dana Huskens; Jan Balzarini; Els J M Van Damme; Jan-Christoph Kehr; Elke Dittmann; Michael D Swanson; David M Markovitz; Dominique Schols
Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).
Antiviral research 2011;90(3):200-4.
2011: Mieke Gouwy; Sofie Struyf; Nele Berghmans; Christophe Vanormelingen; Dominique Schols; Jo Van Damme
CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection.
European journal of immunology 2011;41(4):963-73.
2011: Marijke M F Alen; Jan Balzarini; Tine De Burghgraeve; Suzanne J F Kaptein; Johan Neyts; Dominique Schols
Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells.
PloS one 2011;6(6):e21658.
2011: Bart Hoorelbeke; Els Jm Van Damme; Pierre Rougé; Dominique Schols; Kristel Van Laethem; Elke Fouquaert; Jan Balzarini
Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity.
Retrovirology 2011;8(1):10.
2010: Suzanne J F Kaptein; Tine De Burghgraeve; Matheus Froeyen; Boris Pastorino; Marijke M F Alen; Juan A Mondotte; Piet Herdewijn; Michael Jacobs; Xavier de Lamballerie; Dominique Schols; Andrea V Gamarnik; Ferenc Sztaricskai; Johan Neyts
A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro.
Antimicrobial agents and chemotherapy 2010;54(12):5269-80.
2010: Valentina Svicher; Claudia Alteri; Anna Artese; Federica Forbici; Maria Mercedes Santoro; Dominique Schols; Kristel Van Laethem; Stefano Alcaro; Giosuè Costa; Chiara Tommasi; Mauro Zaccarelli; Pasquale Narciso; Andrea Antinori; Francesca Ceccherini-Silberstein; Jan Balzarini; Carlo Federico Perno
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens.
Journal of acquired immune deficiency syndromes (1999) 2010;55(3):336-44.
2010: Dana Huskens; Geoffrey Férir; Kurt Vermeire; Jan-Christoph Kehr; Jan Balzarini; Elke Dittmann; Dominique Schols
Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile.
The Journal of biological chemistry 2010;285(32):24845-54.
2010: Bart Hoorelbeke; Dana Huskens; Geoffrey Férir; Katrien O François; Atsushi Takahashi; Kristel Van Laethem; Dominique Schols; Haruo Tanaka; Jan Balzarini
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope.
Antimicrobial agents and chemotherapy 2010;54(8):3287-301.
2010: Jan Balzarini; Katrien O François; Kristel Van Laethem; Bart Hoorelbeke; Marleen Renders; Joeri Auwerx; Sandra Liekens; Toshikazu Oki; Yasuhiro Igarashi; Dominique Schols
Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
Antimicrobial agents and chemotherapy 2010;54(4):1425-35.
2010: Christophe Vanpouille; Andrea Lisco; Marco Derudas; Elisa Saba; Jean-Charles Grivel; Beda Brichacek; Francesca Scrimieri; Ray F Schinazi; Dominique Schols; Christopher McGuigan; Jan Balzarini; Leonid Margolis
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.
The Journal of infectious diseases 2010;201(4):635-43.
2010: Sandra Liekens; Dominique Schols; Sigrid Hatse
CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.
Current pharmaceutical design 2010;16(35):3903-20.
2009: Mohammad-Ali Jenabian; Héla Saïdi; Charlotte Charpentier; Yven Van Herrewege; Jong Chan Son; Dominique Schols; Jan Balzarini; Guido Vanham; Laurent Bélec
In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).
The Journal of antimicrobial chemotherapy 2009;64(6):1192-5.
2009: Katrien O François; Christophe Pannecouque; Joeri Auwerx; Virginia Lozano; María-Jesús Pérez-Pérez; Dominique Schols; Jan Balzarini
The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.
Antimicrobial agents and chemotherapy 2009;53(11):4852-9.
2009: Dana Huskens; Kurt Vermeire; Albert T Profy; Dominique Schols
The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1.
Antiviral research 2009;84(1):38-47.
2009: Kurt Vermeire; Kristel Van Laethem; Wouter Janssens; Thomas W Bell; Dominique Schols
Human immunodeficiency virus type 1 escape from cyclotriazadisulfonamide-induced CD4-targeted entry inhibition is associated with increased neutralizing antibody susceptibility.
Journal of virology 2009;83(18):9577-83.
2009: Joeri Auwerx; Katrien O François; Els Vanstreels; Kristel Van Laethem; Dirk Daelemans; Dominique Schols; Jan Balzarini
Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions.
Antiviral research 2009;83(1):61-70.
2009: Marijke M F Alen; Suzanne J F Kaptein; Tine De Burghgraeve; Jan Balzarini; Johan Neyts; Dominique Schols
Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection.
Virology 2009;387(1):67-75.
2009: Sofie Struyf; Samuel Noppen; Tamara Loos; Anneleen Mortier; Mieke Gouwy; Hannelien Verbeke; Dana Huskens; Souphalone Luangsay; Marc Parmentier; Karel Geboes; Dominique Schols; Jo Van Damme; Paul Proost
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):666-74.
2008: Joachim Brouwers; Kurt Vermeire; Dominique Schols; Patrick Augustijns
Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection.
Virology 2008;378(2):306-10.
2008: Katrien O François; Joeri Auwerx; Dominique Schols; Jan Balzarini
Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development.
Molecular pharmacology 2008;74(2):330-7.
2008: Kurt Vermeire; Joachim Brouwers; Yven Van Herrewege; Roger Le Grand; Guido Vanham; Patrick Augustijns; Thomas W Bell; Dominique Schols
CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor.
Current HIV research 2008;6(3):246-56.
2008: Michela Pollicita; Dominique Schols; Stefano Aquaro; W J Peumans; E J M Van Damme; Carlo Federico Perno; Jan Balzarini
Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes.
Virology 2008;370(2):382-91.
2008: Dana Huskens; Kurt Vermeire; Elise Vandemeulebroucke; Jan Balzarini; Dominique Schols
Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent.
The international journal of biochemistry & cell biology 2008;40(12):2802-14.
2007: Mette M Rosenkilde; Lars-Ole Gerlach; Sigrid Hatse; Renato T Skerlj; Dominique Schols; Gary J Bridger; Thue W Schwartz
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.
The Journal of biological chemistry 2007;282(37):27354-65.
2007: Kurt Vermeire; Andrea Lisco; Jean-Charles Grivel; Emily Scarbrough; Kaka Dey; Noah Duffy; Leonid Margolis; Thomas W Bell; Dominique Schols
Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity.
Biochemical pharmacology 2007;74(4):566-78.
2007: Dana Huskens; Katrien Princen; Michael Schreiber; Dominique Schols
The role of N-glycosylation sites on the CXCR4 receptor for CXCL-12 binding and signaling and X4 HIV-1 viral infectivity.
Virology 2007;363(2):280-7.
2007: Dana Huskens; Kristel Van Laethem; Kurt Vermeire; Jan Balzarini; Dominique Schols
Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.
Virology 2007;360(2):294-304.
2007: Sigrid Hatse; Dana Huskens; Katrien Princen; Kurt Vermeire; Gary J Bridger; Erik De Clercq; Mette M Rosenkilde; Thue W Schwartz; Dominique Schols
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor.
Journal of virology 2007;81(7):3632-9.
2007: Miguel Stevens; Michela Pollicita; Christophe Pannecouque; Erik Verbeken; Oriana Tabarrini; Violetta Cecchetti; Stefano Aquaro; Carlo Federico Perno; Arnaldo Fravolini; Erik De Clercq; Dominique Schols; Jan Balzarini
Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives.
Antimicrobial agents and chemotherapy 2007;51(4):1407-13.
2007: Michela Pollicita; Michael R Ruff; Candace B Pert; Maria T Polianova; Dominique Schols; Alessandro Ranazzi; Carlo Federico Perno; Stefano Aquaro
Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells.
Antiviral chemistry & chemotherapy 2007;18(5):285-95.
2007: Andrea Lisco; Jean-Charles Grivel; Angelique Biancotto; Christophe Vanpouille; Francesco Origgi; Mauro S Malnati; Dominique Schols; Paolo Lusso; Leonid Margolis
Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation.
Journal of virology 2007;81(2):708-17.
2007: Jan Balzarini; Yven Van Herrewege; Kurt Vermeire; Guido Vanham; Dominique Schols
Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes.
Molecular pharmacology 2007;71(1):3-11.
2007: Jan Balzarini; Kristel Van Laethem; Dirk Daelemans; Sigrid Hatse; Antonella Bugatti; MARCO RUSNATI; Yasuhiro Igarashi; Toshikazu Oki; Dominique Schols
Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus.
Journal of virology 2007;81(1):362-73.
2006: Stefano Aquaro; Valentina Svicher; Dominique Schols; Michela Pollicita; Andrea Antinori; Jan Balzarini; Carlo Federico Perno
Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies.
Journal of leukocyte biology 2006;80(5):1103-10.
2006: Dominique Schols
HIV coreceptor CXCR4 antagonists.
Current opinion in HIV and AIDS 2006;1(5):361-6.
2006: Jan Balzarini; Kristel Van Laethem; Willy J Peumans; Els J M Van Damme; Anders Bolmstedt; Federico Gago; Dominique Schols
Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes.
Journal of virology 2006;80(17):8411-21.
2006: Carlo Federico Perno; Valentina Svicher; Dominique Schols; Michela Pollicita; Jan Balzarini; Stefano Aquaro
Therapeutic strategies towards HIV-1 infection in macrophages.
Antiviral research 2006;71(2-3):293-300.
2006: Dominique Schols
HIV co-receptor inhibitors as novel class of anti-HIV drugs.
Antiviral research 2006;71(2-3):216-26.
2006: Thomas W Bell; Sreenivasa Anugu; Patrick Bailey; Vincent J Catalano; Kaka Dey; Michael G B Drew; Noah H Duffy; Qi Jin; Meinrado F Samala; Andrej Sodoma; William H Welch; Dominique Schols; Kurt Vermeire
Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues.
Journal of medicinal chemistry 2006;49(4):1291-312.
2006: Kurt Vermeire; Dominique Schols; Thomas W Bell
Inhibitors of HIV infection via the cellular CD4 receptor.
Current medicinal chemistry 2006;13(7):731-43.
2005: Jan Balzarini; Kristel Van Laethem; Sigrid Hatse; Matheus Froeyen; Willy J Peumans; Els J M Van Damme; Dominique Schols
Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIV.
The Journal of biological chemistry 2005;280(49):41005-14.
2005: Katrien Princen; Dominique Schols
HIV chemokine receptor inhibitors as novel anti-HIV drugs.
Cytokine & growth factor reviews 2005;16(6):659-77.
2005: Stuart G Turville; Kurt Vermeire; Jan Balzarini; Dominique Schols
Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer.
Journal of virology 2005;79(21):13519-27.
2005: Kurt Vermeire; Dominique Schols
Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor.
Expert opinion on investigational drugs 2005;14(10):1199-212.
2005: Sigrid Hatse; Katrien Princen; Erik De Clercq; Mette M Rosenkilde; Thue W Schwartz; Pedro E Hernandez-Abad; Renato T Skerlj; Gary J Bridger; Dominique Schols
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.
Biochemical pharmacology 2005;70(5):752-61.
2005: Kurt Vermeire; Dominique Schols
Cyclotriazadisulfonamides: promising new CD4-targeted anti-HIV drugs.
The Journal of antimicrobial chemotherapy 2005;56(2):270-2.
2005: Jan Balzarini; Kristel Van Laethem; Sigrid Hatse; Matheus Froeyen; Els J M Van Damme; Anders Bolmstedt; Willy J Peumans; Erik De Clercq; Dominique Schols
Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.
Molecular pharmacology 2005;67(5):1556-65.
2005: Jan Balzarini; Miguel Stevens; Erik De Clercq; Dominique Schols; Christophe Pannecouque
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.
The Journal of antimicrobial chemotherapy 2005;55(2):135-8.
2005: Bert De Klerck; Lies Geboes; Sigrid Hatse; Hilde Kelchtermans; Yves Meyvis; Kurt Vermeire; Gary J Bridger; An D Billiau; Dominique Schols; Patrick Matthys
Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis.
Arthritis research & therapy 2005;7(6):R1208-20.
2004: Katrien Princen; Sigrid Hatse; Kurt Vermeire; Stefano Aquaro; Erik De Clercq; Lars-Ole Gerlach; Mette M Rosenkilde; Thue W Schwartz; Renato T Skerlj; Gary J Bridger; Dominique Schols
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist.
Journal of virology 2004;78(23):12996-3006.
2004: Kurt Vermeire; Katrien Princen; Sigrid Hatse; Erik De Clercq; Kaka Dey; Thomas W Bell; Dominique Schols
CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro.
AIDS (London, England) 2004;18(16):2115-25.
2004: Jan Balzarini; Sigrid Hatse; Kurt Vermeire; Katrien Princen; Stefano Aquaro; Carlo Federico Perno; Erik De Clercq; Herman Egberink; Guy Vanden Mooter; Willy J Peumans; Els J M Van Damme; Dominique Schols
Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection.
Antimicrobial agents and chemotherapy 2004;48(10):3858-70.
2004: Craig W Hendrix; Ann C Collier; Michael M Lederman; Dominique Schols; Richard B Pollard; Stephen Brown; J Brooks Jackson; Robert W Coombs; Marshall J Glesby; Charles Flexner; Gary J Bridger; Karin Badel; Ronald T MacFarland; Geoffrey Henson; Gary Calandra
Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.
Journal of acquired immune deficiency syndromes (1999) 2004;37(2):1253-62.
2004: Sigrid Hatse; Katrien Princen; Sandra Liekens; Kurt Vermeire; Erik De Clercq; Dominique Schols
Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;61(2):178-88.
2004: Jan Balzarini; Elin Andersson; Dominique Schols; Paul Proost; Jo Van Damme; Bo Svennerholm; Peter Horal; Anders Vahlne
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).
The international journal of biochemistry & cell biology 2004;36(9):1848-59.
2004: Kurt Vermeire; Dominique Schols; Thomas W Bell
CD4 down-modulating compounds with potent anti-HIV activity.
Current pharmaceutical design 2004;10(15):1795-803.
2004: Katrien Princen; Sigrid Hatse; Kurt Vermeire; Erik De Clercq; Dominique Schols
Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists.
Retrovirology 2004;1():2.
2004: Dominique Schols
HIV co-receptors as targets for antiviral therapy.
Current topics in medicinal chemistry 2004;4(9):883-93.
2003: Katrien Princen; Sigrid Hatse; Kurt Vermeire; Gary J Bridger; Renato T Skerlj; Erik De Clercq; Dominique Schols
The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.
AIDS research and human retroviruses 2003;19(12):1135-9.
2003: Kurt Vermeire; Dominique Schols
Specific CD4 down-modulating compounds with potent anti-HIV activity.
Journal of leukocyte biology 2003;74(5):667-75.
2003: Sigrid Hatse; Katrien Princen; Kurt Vermeire; Lars-Ole Gerlach; Mette M Rosenkilde; Thue W Schwartz; Gary J Bridger; Erik De Clercq; Dominique Schols
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
FEBS letters 2003;546(2-3):300-6.
2003: Sigrid Hatse; Gary J Bridger; Erik De Clercq; Dominique Schols
X4 HIV-1 induces neuroblastoma cell death by interference with CXCL12/CXCR4 interaction.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49 Online Pub():OL443-52.
2003: Katrien Princen; Sigrid Hatse; Kurt Vermeire; Erik De Clercq; Dominique Schols
Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;51(1):35-45.
2003: Kurt Vermeire; Thomas W Bell; Heung-Jin Choi; Qi Jin; Meinrado F Samala; Andrej Sodoma; Erik De Clercq; Dominique Schols
The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor.
Molecular pharmacology 2003;63(1):203-10.
2002: Brian R Lane; Jianguo Liu; Paul J Bock; Dominique Schols; Michael J Coffey; Robert M Strieter; Peter J Polverini; David M Markovitz
Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma.
Journal of virology 2002;76(22):11570-83.
2002: Kurt Vermeire; Ying Zhang; Katrien Princen; Sigrid Hatse; Meinrado F Samala; Kaka Dey; Heung-Jin Choi; Youngmi Ahn; Andrej Sodoma; Robert Snoeck; Graciela Andrei; Erik De Clercq; Thomas W Bell; Dominique Schols
CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor.
Virology 2002;302(2):342-53.
2002: Sigrid Hatse; Katrien Princen; Gary J Bridger; Erik De Clercq; Dominique Schols
Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.
FEBS letters 2002;527(1-3):255-62.
2002: Robert Snoeck; Graciela Andrei; Bahram Bodaghi; Laurence Lagneaux; Dirk Daelemans; Erik De Clercq; Johan Neyts; Dominique Schols; Lieve Naesens; Susan Michelson; Dominique Bron; Michael J Otto; Anne Bousseau; Conception Nemecek; Christine Roy
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.
Antiviral research 2002;55(3):413-24.
2002: Nicholas W Lukacs; Aaron A Berlin; Dominique Schols; Renato T Skerlj; Gary J Bridger
AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
The American journal of pathology 2002;160(4):1353-60.
2002: Paul Proost; Dominique Schols
[Role of chemokines in the HIV infection process].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2002;64(6):403-20.
2001: Erik De Clercq; Lieve Naesens; Leen De Bolle; Dominique Schols; Ying Zhang; Johan Neyts
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.
Reviews in medical virology 2001;11(6):381-95.
2001: Ying Zhang; Leen De Bolle; Stefano Aquaro; Alfons Van Lommel; Erik De Clercq; Dominique Schols
Productive infection of primary macrophages with human herpesvirus 7.
Journal of virology 2001;75(21):10511-4.
2001: Patrick Matthys; Sigrid Hatse; Kurt Vermeire; Anja Wuyts; Gary J Bridger; Geoffrey Henson; Erik De Clercq; An D Billiau; Dominique Schols
AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4686-92.
2001: Sofie Struyf; Patricia Menten; Jean-Pierre Lenaerts; Willy Put; A D'Haese; Erik De Clercq; Dominique Schols; Paul Proost; Jo Van Damme
Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils.
European journal of immunology 2001;31(7):2170-8.
2001: Sigrid Hatse; Katrien Princen; Lars-Ole Gerlach; Gary J Bridger; Geoffrey Henson; Erik De Clercq; Thue W Schwartz; Dominique Schols
Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.
Molecular pharmacology 2001;60(1):164-73.
2001: Stefano Aquaro; Patricia Menten; Sofie Struyf; Paul Proost; Jo Van Damme; Erik De Clercq; Dominique Schols
The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages.
Journal of virology 2001;75(9):4402-6.
2001: Erik De Clercq; Graciela Andrei; Robert Snoeck; Leen De Bolle; Lieve Naesens; B Degrève; Jan Balzarini; Ying Zhang; Dominique Schols; Pieter Leyssen; Chunxiao Ying; Johan Neyts
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):271-85.
2001: N Malkevitch; David H McDermott; Y Yi; Jean-Charles Grivel; Dominique Schols; E De Clercq; Philip M Murphy; Svetlana Glushakova; R G Collman; Leonid Margolis
Coreceptor choice and T cell depletion by R5, X4, and R5X4 HIV-1 variants in CCR5-deficient (CCR5delta32) and normal human lymphoid tissue.
Virology 2001;281(2):239-47.
2001: Erik De Clercq; Dominique Schols
Inhibition of HIV infection by CXCR4 and CCR5 chemokine receptor antagonists.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():19-31.
2000: Myriam Witvrouw; Valery Fikkert; Wim Pluymers; Barry Matthews; K Mardel; Dominique Schols; J Raff; zeger debyser; Erik De Clercq; George Holan; Christophe Pannecouque
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Molecular pharmacology 2000;58(5):1100-8.
2000: Wim Pluymers; Nouri Neamati; Christophe Pannecouque; Valery Fikkert; C Marchand; Terrence R Burke; Y Pommier; Dominique Schols; Erik De Clercq; zeger debyser; Myriam Witvrouw
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
Molecular pharmacology 2000;58(3):641-8.
2000: Myriam Witvrouw; H Weigold; Christophe Pannecouque; Dominique Schols; Erik De Clercq; George Holan
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.
Journal of medicinal chemistry 2000;43(5):778-83.
2000: Ying Zhang; Sigrid Hatse; Erik De Clercq; Dominique Schols
CXC-chemokine receptor 4 is not a coreceptor for human herpesvirus 7 entry into CD4(+) T cells.
Journal of virology 2000;74(4):2011-6.
2000: Dirk Daelemans; Dominique Schols; Myriam Witvrouw; Christophe Pannecouque; Sigrid Hatse; Sonia Van Dooren; François Hamy; Thomas Klimkait; Erik De Clercq; Anne-Mieke Vandamme
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.
Molecular pharmacology 2000;57(1):116-24.
1999: Gary J Bridger; Renato T Skerlj; S Padmanabhan; S A Martellucci; Geoffrey Henson; Sofie Struyf; Myriam Witvrouw; Dominique Schols; Erik De Clercq
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.
Journal of medicinal chemistry 1999;42(19):3971-81.
1999: Patrick Matthys; Kurt Vermeire; Tania Mitera; Hubertine Heremans; S Huang; Dominique Schols; Christiane De Wolf-Peeters; An D Billiau
Enhanced autoimmune arthritis in IFN-gamma receptor-deficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3503-10.
1999: Svetlana Glushakova; Y Yi; Jean-Charles Grivel; A Singh; Dominique Schols; E De Clercq; R G Collman; Leonid Margolis
Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.
The Journal of clinical investigation 1999;104(5):R7-R11.
1999: Yanjie Yi; Stuart N Isaacs; D A Williams; I Frank; Dominique Schols; Erik De Clercq; Dennis L Kolson; Ronald G Collman
Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism.
Journal of virology 1999;73(9):7117-25.
1999: Ying Zhang; Dominique Schols; Erik De Clercq
Selective activity of various antiviral compounds against HHV-7 infection.
Antiviral research 1999;43(1):23-35.
1999: Patricia Menten; Sofie Struyf; Evemie Schutyser; Anja Wuyts; Erik De Clercq; Dominique Schols; Paul Proost; Jo Van Damme
The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine.
The Journal of clinical investigation 1999;104(4):R1-5.
1999: Herman F Egberink; Erik De Clercq; Arno L W van Vliet; J Balzarini; Gary J Bridger; Geoffrey Henson; Marian C Horzinek; Dominique Schols
Bicyclams, selective antagonists of the human chemokine receptor CXCR4, potently inhibit feline immunodeficiency virus replication.
Journal of virology 1999;73(8):6346-52.
1999: José A Esté; C Cabrera; Julià Blanco; A Gutierrez; Gary J Bridger; Geoffrey Henson; Bonaventura Clotet; Dominique Schols; Erik De Clercq
Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4.
Journal of virology 1999;73(7):5577-85.
1999: Wim Pluymers; Peter Cherepanov; Dominique Schols; Erik De Clercq; zeger debyser
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.
Virology 1999;258(2):327-32.
1999: Sofie Struyf; Paul Proost; Dominique Schols; Erik De Clercq; Ghislain Opdenakker; Jean-Pierre Lenaerts; Michel detheux; Marc Parmentier; Ingrid De Meester; Simon Scharpé; Jo Van Damme
CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4903-9.
1999: Paul Proost; Sofie Struyf; Dominique Schols; Ghislain Opdenakker; S Sozzani; Paola Allavena; Alberto Mantovani; Koen Augustyns; Gunther Bal; Achiel Haemers; Anne-Marie Lambeir; Simon Scharpé; Jo Van Damme; Ingrid De Meester
Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.
The Journal of biological chemistry 1999;274(7):3988-93.
1999: Jo Van Damme; Sofie Struyf; Anja Wuyts; Els Van Coillie; Patricia Menten; Dominique Schols; S Sozzani; Ingrid De Meester; Paul Proost
The role of CD26/DPP IV in chemokine processing.
Chemical immunology 1999;72():42-56.
1999: José A Esté; C Cabrera; Erik De Clercq; Sofie Struyf; J Van Damme; Gary J Bridger; Renato T Skerlj; M J Abrams; Geoffrey Henson; A Gutierrez; Bonaventura Clotet; Dominique Schols
Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor.
Molecular pharmacology 1999;55(1):67-73.
1998: Dominique Schols; P Proost; Sofie Struyf; Anja Wuyts; Ingrid De Meester; S Scharpé; J Van Damme; Erik De Clercq
CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.
Antiviral research 1998;39(3):175-87.
1998: Sofie Struyf; Paul Proost; S Sozzani; Alberto Mantovani; Anja Wuyts; Erik De Clercq; Dominique Schols; Jo Van Damme
Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2672-5.
1998: Paul Proost; Sofie Struyf; Anja Wuyts; Patricia Menten; Ingrid De Meester; Anne-Marie Lambeir; Simon Scharpé; Dominique Schols; Erik De Clercq; Jo Van Damme
Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: effects of posttranslational modifications on receptor usage, chemotactic and anti-HIV-1 activity.
European cytokine network 1998;9(3 Suppl):73-5.
1998: Dominique Schols; Erik De Clercq
The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells.
The Journal of general virology 1998;79 ( Pt 9)():2203-5.
1998: Paul Proost; Sofie Struyf; Dominique Schols; Christine Durinx; Anja Wuyts; Jean-Pierre Lenaerts; Erik De Clercq; Ingrid De Meester; Jo Van Damme
Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1alpha.
FEBS letters 1998;432(1-2):73-6.
1998: Dominique Schols; José A Esté; C Cabrera; Erik De Clercq
T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use.
Journal of virology 1998;72(5):4032-7.
1998: Paul Proost; Ingrid De Meester; Dominique Schols; Sofie Struyf; Anne-Marie Lambeir; Anja Wuyts; Ghislain Opdenakker; Erik De Clercq; Simon Scharpé; Jo Van Damme
Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
The Journal of biological chemistry 1998;273(13):7222-7.
1998: José A Esté; C Cabrera; Dominique Schols; Peter Cherepanov; A Gutierrez; Myriam Witvrouw; Christophe Pannecouque; zeger debyser; RF Rando; B Clotet; Jan Desmyter; E De Clercq
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
Molecular pharmacology 1998;53(2):340-5.
1998: G A Donzella; Dominique Schols; SW Lin; José A Esté; Kirsten A Nagashima; Paul J Maddon; GP Allaway; Thomas P Sakmar; Geoffrey Henson; Erik De Clercq; John P Moore
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
Nature medicine 1998;4(1):72-7.
1997: Dominique Schols; Sofie Struyf; J Van Damme; José A Esté; Geoffrey Henson; Erik De Clercq
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4.
The Journal of experimental medicine 1997;186(8):1383-8.
1997: Dominique Schols; Paul Proost; Jo Van Damme; Erik De Clercq
RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE).
Journal of virology 1997;71(10):7300-4.
1997: Dominique Schols; José A Esté; Geoffrey Henson; Erik De Clercq
Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.
Antiviral research 1997;35(3):147-56.
1997: J A Este; Dominique Schols; K De Vreese; Kristel Van Laethem; Anne-Mieke Vandamme; Jan Desmyter; Erik De Clercq
Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein.
Molecular pharmacology 1997;52(1):98-104.
1997: Myriam Witvrouw; Jan Balzarini; Christophe Pannecouque; S Jhaumeer-Laulloo; José A Esté; Dominique Schols; Peter Cherepanov; Jean-Claude Schmit; zeger debyser; Anne-Mieke Vandamme; Jan Desmyter; S R Ramadas; Erik De Clercq
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1997;41(2):262-8.
1996: Dominique Schols; E De Clercq
Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production.
Journal of virology 1996;70(8):4953-60.
1996: Jan Balzarini; H Pelemans; Stefano Aquaro; Carlo Federico Perno; Myriam Witvrouw; Dominique Schols; E De Clercq; Anna Karlsson
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.
Molecular pharmacology 1996;50(2):394-401.
1996: Alain Leydet; H El Hachemi; B Boyer; G Lamaty; JP Roque; Dominique Schols; Robert Snoeck; Graciela Andrei; S Ikeda; Johan Neyts; D Reymen; J Este; Myriam Witvrouw; E De Clercq
Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides.
Journal of medicinal chemistry 1996;39(8):1626-34.
1995: Johan Neyts; D Reymen; Didier Letourneur; J Jozefonvicz; Dominique Schols; J Este; Graciela Andrei; P McKenna; Myriam Witvrouw; S Ikeda
Differential antiviral activity of derivatized dextrans.
Biochemical pharmacology 1995;50(6):743-51.
1994: Rudi Pauwels; Koen Andries; zeger debyser; M J Kukla; Dominique Schols; H J Breslin; R Woestenborghs; Jan Desmyter; M A Janssen; E De Clercq
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.
Antimicrobial agents and chemotherapy 1994;38(12):2863-70.
1993: Robert Snoeck; Graciela Andrei; Johan Neyts; Dominique Schols; M Cools; Jan Balzarini; E De Clercq
Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication.
Antiviral research 1993;21(3):197-216.
1993: Rudi Pauwels; Koen Andries; zeger debyser; P Van Daele; Dominique Schols; P Stoffels; K De Vreese; R Woestenborghs; Anne-Mieke Vandamme; C G Janssen
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1711-5.
1993: Jan Balzarini; A Holy; J Jindrich; Lieve Naesens; Robert Snoeck; Dominique Schols; E De Clercq
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.
Antimicrobial agents and chemotherapy 1993;37(2):332-8.
1992: Robert Snoeck; Graciela Andrei; Dominique Schols; Jan Balzarini; E De Clercq
Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1992;11(12):1144-55.
1992: Myriam Witvrouw; Rudi Pauwels; Anne-Mieke Vandamme; Dominique Schols; D Reymen; N Yamamoto; Jan Desmyter; E De Clercq
Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335.
Antimicrobial agents and chemotherapy 1992;36(12):2628-33.
1992: N Yamamoto; Dominique Schols; E De Clercq; zeger debyser; Rudi Pauwels; Jan Balzarini; H Nakashima; M Baba; M Hosoya; Robert Snoeck
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.
Molecular pharmacology 1992;42(6):1109-17.
1992: Robert Snoeck; Dominique Schols; Catherine Sadzot; J M Cloes; Graciela Andrei; E De Clercq; Jacques Piette; Bernard Rentier
Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents.
Journal of virological methods 1992;38(2):243-54.
1992: Dominique Schols; Rudi Pauwels; Jan Desmyter; E De Clercq
Presence of class II histocompatibility DR proteins on the envelope of human immunodeficiency virus demonstrated by FACS analysis.
Virology 1992;189(1):374-6.
1992: Johan Neyts; Robert Snoeck; Dominique Schols; Jan Balzarini; J D Esko; Ann Van Schepdael; E De Clercq
Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate.
Virology 1992;189(1):48-58.
1992: E De Clercq; N Yamamoto; Rudi Pauwels; M Baba; Dominique Schols; H Nakashima; Jan Balzarini; zeger debyser; B A Murrer; D Schwartz
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5286-90.
1992: Jan Balzarini; Johan Neyts; Dominique Schols; M Hosoya; Els J M Van Damme; Willy J Peumans; E De Clercq
The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro.
Antiviral research 1992;18(2):191-207.
1992: Jan Balzarini; María-Jesús Pérez-Pérez; Ana San-Félix; Dominique Schols; Carlo Federico Perno; Anne-Mieke Vandamme; María-José Camarasa; E De Clercq
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4392-6.
1992: Rudi Pauwels; Koen Andries; zeger debyser; M Kukla; Dominique Schols; Jan Desmyter; E De Clercq; P A Janssen
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication.
Biochemical Society transactions 1992;20(2):509-12.
1991: Graciela Andrei; Robert Snoeck; Dominique Schols; Patrick Goubau; Jan Desmyter; E De Clercq
Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1991;10(12):1026-33.
1991: Johan Neyts; Robert Snoeck; Dominique Schols; Bernard Himpens; E De Clercq
Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anti-cytomegalovirus agents.
Journal of virological methods 1991;35(1):27-38.
1991: Jan Balzarini; C K Lee; Dominique Schols; E De Clercq
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes.
Biochemical and biophysical research communications 1991;178(2):563-9.
1991: Jan Balzarini; Carlo Federico Perno; Dominique Schols; E De Clercq
Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes.
Biochemical and biophysical research communications 1991;178(1):329-35.
1991: Robert Snoeck; Dominique Schols; Graciela Andrei; Johan Neyts; E De Clercq
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.
Antiviral research 1991;16(1):1-9.
1991: Jan Balzarini; Dominique Schols; Johan Neyts; Els J M Van Damme; Willy J Peumans; E De Clercq
Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro.
Antimicrobial agents and chemotherapy 1991;35(3):410-6.
1991: R Pauwels; Dominique Schols
Development of new potent and selective agents against HIV (human immunodeficiency virus).
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1991;53(6):629-55.
1991: Dominique Schols; P Wutzler; R Klöcking; B Helbig; E De Clercq
Selective inhibitory activity of polyhydroxycarboxylates derived from phenolic compounds against human immunodeficiency virus replication.
Journal of acquired immune deficiency syndromes 1991;4(7):677-85.
1990: Johan Neyts; Robert Snoeck; Dominique Schols; Jan Balzarini; E De Clercq
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).
Virology 1990;179(1):41-50.
1990: H Nakashima; Jan Balzarini; Rudi Pauwels; Dominique Schols; Jan Desmyter; E De Clercq
Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells.
Journal of virological methods 1990;29(2):197-208.
1990: Dominique Schols; Rudi Pauwels; Jan Desmyter; E De Clercq
Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.
Virology 1990;175(2):556-61.
1990: M Baba; E De Clercq; Dominique Schols; Rudi Pauwels; Robert Snoeck; Constant van Boeckel; G Van Dedem; N Kraaijeveld; P Hobbelen; H Ottenheijm
Novel sulfated polysaccharides: dissociation of anti-human immunodeficiency virus activity from antithrombin activity.
The Journal of infectious diseases 1990;161(2):208-13.
1990: Rudi Pauwels; Koen Andries; Jan Desmyter; Dominique Schols; M J Kukla; H J Breslin; A Raeymaeckers; J Van Gelder; R Woestenborghs; J Heykants
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives.
Nature 1990;343(6257):470-4.
1990: M Baba; Dominique Schols; E De Clercq; Rudi Pauwels; M Nagy; J Györgyi-Edelényi; M Löw; S Görög
Novel sulfated polymers as highly potent and selective inhibitors of human immunodeficiency virus replication and giant cell formation.
Antimicrobial agents and chemotherapy 1990;34(1):134-8.
1990: Dominique Schols; Rudi Pauwels; Jan Desmyter; E De Clercq
Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells.
Cytometry 1990;11(6):736-43.
1990: M Baba; Dominique Schols; Rudi Pauwels; H Nakashima; E De Clercq
Sulfated polysaccharides as potent inhibitors of HIV-induced syncytium formation: a new strategy towards AIDS chemotherapy.
Journal of acquired immune deficiency syndromes 1990;3(5):493-9.
1989: M Baba; H Tanaka; E De Clercq; Rudi Pauwels; Jan Balzarini; Dominique Schols; H Nakashima; Carlo Federico Perno; R T Walker; T Miyasaka
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.
Biochemical and biophysical research communications 1989;165(3):1375-81.
1989: Dominique Schols; Robert Snoeck; Johan Neyts; E de Clercq
Detection of immediate early, early and late antigens of human cytomegalovirus by flow cytometry.
Journal of virological methods 1989;26(3):247-54.
1989: H Nakashima; Rudi Pauwels; M Baba; Dominique Schols; Jan Desmyter; E De Clercq
Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds.
Journal of virological methods 1989;26(3):319-29.
1989: Dominique Schols; Rudi Pauwels; M Baba; Jan Desmyter; E De Clercq
Syncytium formation and destruction of bystander CD4+ cells cocultured with T cells persistently infected with human immunodeficiency virus as demonstrated by flow cytometry.
The Journal of general virology 1989;70 ( Pt 9)():2397-408.
1989: Jan Balzarini; Arthur Van Aerschot; Rudi Pauwels; M Baba; Dominique Schols; Piet Herdewijn; E De Clercq
5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine.
Molecular pharmacology 1989;35(5):571-7.
1989: Dominique Schols; M Baba; Rudi Pauwels; Jan Desmyter; E De Clercq
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3322-6.
1989: M Baba; Dominique Schols; H Nakashima; Rudi Pauwels; G Parmentier; D K Meijer; E De Clercq
Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro.
Journal of acquired immune deficiency syndromes 1989;2(3):264-71.
1989: Dominique Schols; M Baba; Rudi Pauwels; E De Clercq
Flow cytometric method to demonstrate whether anti-HIV-1 agents inhibit virion binding to T4+ cells.
Journal of acquired immune deficiency syndromes 1989;2(1):10-5.
1988: Dominique Schols; Rudi Pauwels; F Vanlangendonck; Jan Balzarini; E De Clercq
A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells.
Journal of immunological methods 1988;114(1-2):27-32.
1988: M Baba; Dominique Schols; Rudi Pauwels; Jan Balzarini; E De Clercq
Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro.
Biochemical and biophysical research communications 1988;155(3):1404-11.
1988: M Baba; M Nakajima; Dominique Schols; Rudi Pauwels; Jan Balzarini; E De Clercq
Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro.
Antiviral research 1988;9(6):335-43.
1988: Rudi Pauwels; Jan Balzarini; M Baba; Robert Snoeck; Dominique Schols; Piet Herdewijn; Jan Desmyter; E De Clercq
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.
Journal of virological methods 1988;20(4):309-21.
1988: Rudi Pauwels; Jan Balzarini; Dominique Schols; M Baba; Jan Desmyter; I Rosenberg; A Holy; E De Clercq
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents.
Antimicrobial agents and chemotherapy 1988;32(7):1025-30.