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Ernst Schönbrunn

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Ronil A Patel; Roberta Pireddu; Ernst Schönbrunn; Kara D Forinash; Nicholas J Lawrence; Mathew P Martin; Nan Sun; Ying Sun; Saïd M Sebti
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Mathew P Martin; Riazul Alam; Stephane Betzi; Donna J Ingles; Jin-Yi Zhu; Ernst Schönbrunn
A novel approach to the discovery of small-molecule ligands of CDK2.
Mathew P Martin; Sevil Ozcan; Roberta Pireddu; Riazul Alam; Harshani R Lawrence; Nicholas J Lawrence; Yunting Luo; Said M Sebti; Jin-Yi Zhu; Ernst Schönbrunn
A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

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2012: Ronil A Patel; Roberta Pireddu; Ernst Schönbrunn; Kara D Forinash; Nicholas J Lawrence; Mathew P Martin; Nan Sun; Ying Sun; Saïd M Sebti
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Cancer research 2012;72(19):5025-34.
2012: Mathew P Martin; Riazul Alam; Stephane Betzi; Donna J Ingles; Jin-Yi Zhu; Ernst Schönbrunn
A novel approach to the discovery of small-molecule ligands of CDK2.
Chembiochem : a European journal of chemical biology 2012;13(14):2128-36.
2012: Mathew P Martin; Sevil Ozcan; Roberta Pireddu; Riazul Alam; Harshani R Lawrence; Nicholas J Lawrence; Yunting Luo; Said M Sebti; Jin-Yi Zhu; Ernst Schönbrunn
A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.
ACS chemical biology 2012;7(4):698-706.
2012: Jin-Yi Zhu; Yan Yang; Stephane Betzi; Huijong Han; Frank Marsilio; Sanne H Olesen; Ernst Schönbrunn
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA).
The Journal of biological chemistry 2012;287(16):12657-67.
2012: Jae Chul Lee; Ernst Schönbrunn; Joseph S Tash; Yan Yang; Jin-Yi Zhu; Dinah Dutta; Subhashree Francis; Vijayalaxmi Gupta; Gunda I Georg
Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.
The Journal of organic chemistry 2012;77(7):3082-98.
2011: Stephane Betzi; Gunda I Georg; Huijong Han; Sudhakar R Jakkaraj; Donna J Lubbers; Mathew Martin; Riazul Alam; Ernst Schönbrunn
Discovery of a potential allosteric ligand binding site in CDK2.
ACS chemical biology 2011;6(5):492-501.
2010: Norbert Berndt; H Yang; B Trinczek; S Betzi; Z Zhang; B Wu; N J Lawrence; M Pellecchia; Ernst Schönbrunn; J Q Cheng; S M Sebti
The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane.
Cell death and differentiation 2010;17(11):1795-804.
2010: Huijong Han; Yan Yang; Sanne H Olesen; Andreas Becker; Stephane Betzi; Ernst Schönbrunn
The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .
Biochemistry 2010;49(19):4276-82.
2010: Jason Phan; Zhenyu Li; Agnieszka Kasprzak; Baozong Li; Said Sebti; Wayne Guida; Ernst Schönbrunn; Jiandong Chen
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
The Journal of biological chemistry 2010;285(3):2174-83.
2010: Kiran N Mahajan; Domenico Coppola; Sridevi Challa; Bin Fang; Y Ann Chen; Weiwei Zhu; Alexis S Lopez; John Koomen; Robert W Engelman; Charlene Rivera; Rebecca S Muraoka-Cook; Jin Q Cheng; Ernst Schönbrunn; Said M Sebti; H Shelton Earp; Nupam P Mahajan
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
PloS one 2010;5(3):e9646.
2009: Todd Funke; Yan Yang; Huijong Han; Martha Healy-Fried; Sanne Olesen; Andreas Becker; Ernst Schönbrunn
Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli.
The Journal of biological chemistry 2009;284(15):9854-60.
2009: Aileen Y Alontaga; Juan Carlos Rodriguez; Ernst Schönbrunn; Andreas Becker; Todd Funke; Erik T Yukl; Takahiro Hayashi; Jordan Stobaugh; Pierre Moanne-Loccoz; Mario Rivera
Structural characterization of the hemophore HasAp from Pseudomonas aeruginosa: NMR spectroscopy reveals protein-protein interactions between Holo-HasAp and hemoglobin.
Biochemistry 2009;48(1):96-109.
2008: An Wang; Juan Carlos Rodríguez; Huijong Han; Ernst Schönbrunn; Mario Rivera
X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa.
Biochemistry 2008;47(31):8080-93.
2007: Todd Funke; Martha L Healy-Fried; Huijong Han; David G Alberg; Paul A Bartlett; Ernst Schönbrunn
Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.
Biochemistry 2007;46(46):13344-51.
2007: Martha L Healy-Fried; Todd Funke; Melanie A Priestman; Huijong Han; Ernst Schönbrunn
Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
The Journal of biological chemistry 2007;282(45):32949-55.
2007: An Wang; Yuhong Zeng; Huijong Han; Saroja Weeratunga; Bailey N Morgan; Pierre Moanne-Loccoz; Ernst Schönbrunn; Mario Rivera
Biochemical and structural characterization of Pseudomonas aeruginosa Bfd and FPR: ferredoxin NADP+ reductase and not ferredoxin is the redox partner of heme oxygenase under iron-starvation conditions.
Biochemistry 2007;46(43):12198-211.
2006: Todd Funke; Huijong Han; Martha L Healy-Fried; Markus Fischer; Ernst Schönbrunn
Molecular basis for the herbicide resistance of Roundup Ready crops.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13010-5.
2006: Qingshan Li; Robert P Hanzlik; Robert F Weaver; Ernst Schönbrunn
Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core.
Biochemistry 2006;45(3):701-8.
2005: Melanie A Priestman; Martha L Healy; Todd Funke; Andreas Becker; Ernst Schönbrunn
Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate.
FEBS letters 2005;579(25):5773-80.
2005: Susanne Eschenburg; Melanie A Priestman; Farid A Abdul-Latif; Carole Delachaume; Florence Fassy; Ernst Schönbrunn
A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).
The Journal of biological chemistry 2005;280(14):14070-5.
2005: Melanie A Priestman; Martha L Healy; Andreas Becker; David G Alberg; Paul A Bartlett; Gerald H Lushington; Ernst Schönbrunn
Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail.
Biochemistry 2005;44(9):3241-8.
2005: Susanne Eschenburg; Melanie A Priestman; Ernst Schönbrunn
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release.
The Journal of biological chemistry 2005;280(5):3757-63.
2005: Melanie A Priestman; Todd Funke; Inder M Singh; Scott S Crupper; Ernst Schönbrunn
5-Enolpyruvylshikimate-3-phosphate synthase from Staphylococcus aureus is insensitive to glyphosate.
FEBS letters 2005;579(3):728-32.
2002: Susanne Eschenburg; Martha L Healy; Melanie A Priestman; Gerald H Lushington; Ernst Schönbrunn
How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli.
Planta 2002;216(1):129-35.
2001: Ernst Schönbrunn; Susanne Eschenburg; Wendy A Shuttleworth; John Vinton Schloss; Nikolaus Amrhein; Jeremy N S Evans; Wolfgang Kabsch
Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1376-80.
2000: Susanne Eschenburg; Ernst Schönbrunn
Comparative X-ray analysis of the un-liganded fosfomycin-target murA.
Proteins 2000;40(2):290-8.
2000: Ernst Schönbrunn; Susanne Eschenburg; F Krekel; Karolin Luger; Nikolaus Amrhein
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.
Biochemistry 2000;39(9):2164-73.
1999: Ernst Schönbrunn; W Phlippen; Bernhard Trinczek; S Sack; Susanne Eschenburg; Eva-Maria Mandelkow; Eckhard Mandelkow
Crystallization of a macromolecular ring assembly of tubulin liganded with the anti-mitotic drug podophyllotoxin.
Journal of structural biology 1999;128(2):211-5.
1998: Peter Macheroux; Ernst Schönbrunn; D I Svergun; V V Volkov; M H Koch; Stephen Bornemann; Roger N F Thorneley
Evidence for a major structural change in Escherichia coli chorismate synthase induced by flavin and substrate binding.
The Biochemical journal 1998;335 ( Pt 2)():319-27.
1998: Ernst Schönbrunn; D I Svergun; Nikolaus Amrhein; M H Koch
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA).
European journal of biochemistry / FEBS 1998;253(2):406-12.
1997: F Kozielski; S Sack; A Marx; M Thormählen; Ernst Schönbrunn; V Biou; A Thompson; Eva-Maria Mandelkow; Eckhard Mandelkow
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
Cell 1997;91(7):985-94.
1997: F Kozielski; Ernst Schönbrunn; S Sack; Jens Müller; Scott T Brady; Eckhard Mandelkow
Crystallization and preliminary X-ray analysis of the single-headed and double-headed motor protein kinesin.
Journal of structural biology 1997;119(1):28-34.
1996: Ernst Schönbrunn; S Sack; S Eschenburg; Anastassis Perraks; F Krekel; Nikolaus Amrhein; Eckhard Mandelkow
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin.
Structure (London, England : 1993) 1996;4(9):1065-75.
1996: S Sack; Z Dauter; C Wanke; Nikolaus Amrhein; Eckhard Mandelkow; Ernst Schönbrunn
Crystallization and preliminary X-ray diffraction analysis of UDP-N-acetylglucosamine enolpyruvyltransferase of Enterobacter cloacae.
Journal of structural biology 1996;117(1):73-6.