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Wilhelm Schoner

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Wilhelm Schoner; Georgios Scheiner-Bobis
Role of endogenous cardiotonic steroids in sodium homeostasis.
Wilhelm Schoner
Salt abuse: the path to hypertension.
Wilhelm Schoner; Georgios Scheiner-Bobis
Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

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All Publications

2008: Wilhelm Schoner; Georgios Scheiner-Bobis
Role of endogenous cardiotonic steroids in sodium homeostasis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(9):2723-9.
2008: Wilhelm Schoner
Salt abuse: the path to hypertension.
Nature medicine 2008;14(1):16-7.
2007: Wilhelm Schoner; Georgios Scheiner-Bobis
Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.
American journal of physiology. Cell physiology 2007;293(2):C509-36.
2007: Wilhelm Schoner; Georgios Scheiner-Bobis
Endogenous and exogenous cardiac glycosides and their mechanisms of action.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2007;7(3):173-89.
2005: Wilhelm Schoner; Georgios Scheiner-Bobis
Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer.
Seminars in nephrology 2005;25(5):343-51.
2005: Natali B Bauer; Jochen Müller-Ehmsen; Ulrike Krämer; Njde Hambarchian; Carsten Zobel; Robert H G Schwinger; Horst Neu; Ulrike Kirch; Ernst-Günther Grünbaum; Wilhelm Schoner
Ouabain-like compound changes rapidly on physical exercise in humans and dogs: effects of beta-blockade and angiotensin-converting enzyme inhibition.
Hypertension 2005;45(5):1024-8.
2004: Rita Krumscheid; Rüdiger Ettrich; Zofie Sovová; Klára Susánková; Zdenek Lánský; Katerina Hofbauerová; Holger Linnertz; Jan Teisinger; Evzen Amler; Wilhelm Schoner
The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site.
European journal of biochemistry / FEBS 2004;271(19):3923-36.
2004: Zdenek Lánský; Martin Kubala; Rüdiger Ettrich; Michal Kutý; Jaromír Plásek; Jan Teisinger; Wilhelm Schoner; Evzen Amler
The hydrogen bonds between Arg423 and Glu472 and other key residues, Asp443, Ser477, and Pro489, are responsible for the formation and a different positioning of TNP-ATP and ATP within the nucleotide-binding site of Na(+)/K(+)-ATPase.
Biochemistry 2004;43(26):8303-11.
2004: Alexander Boldyrev; Elena Bulygina; O Gerassimova; L Lyapina; Wilhelm Schoner
Functional relationship between Na/K-ATPase and NMDA-receptors in rat cerebellum granule cells.
Biochemistry. Biokhimii͡a 2004;69(4):429-34.
2003: Martin Kubala; Jan Teisinger; Rüdiger Ettrich; Katerina Hofbauerová; Vladimír Kopecký; Vladimír Baumruk; Rita Krumscheid; Jaromír Plásek; Wilhelm Schoner; Evzen Amler
Eight amino acids form the ATP recognition site of Na(+)/K(+)-ATPase.
Biochemistry 2003;42(21):6446-52.
2003: Wilhelm Schoner; Natali B Bauer; Jochen Müller-Ehmsen; Ulrike Krämer; Njde Hambarchian; Robert H G Schwinger; Hans Moeller; Holger Kost; Christine Weitkamp; Thomas Schweitzer; Ulrike Kirch; Horst Neu; Ernst-Günther Grünbaum
Ouabain as a mammalian hormone.
Annals of the New York Academy of Sciences 2003;986():678-84.
2003: Alexander Boldyrev; Elena Bulygina; Maria Yuneva; Wilhelm Schoner
Na/K-ATPase regulates intracellular ROS level in cerebellum neurons.
Annals of the New York Academy of Sciences 2003;986():519-21.
2003: Rita Krumscheid; Klára Suánková; Rüdiger Ettrich; Jan Teisinger; Evzen Amler; Wilhelm Schoner
Localization of catalytic active sites in the large cytoplasmic domain of Na+/K+-ATPase.
Annals of the New York Academy of Sciences 2003;986():242-4.
2003: Alexander Boldyrev; Elena Bulygina; David Carpenter; Wilhelm Schoner
Glutamate receptors communicate with Na+/K+-ATPase in rat cerebellum granule cells: demonstration of differences in the action of several metabotropic and ionotropic glutamate agonists on intracellular reactive oxygen species and the sodium pump.
Journal of molecular neuroscience : MN 2003;21(3):213-22.
2002: Martin Kubala; Katerina Hofbauerová; Rüdiger Ettrich; Vladimír Kopecký; Rita Krumscheid; Jaromír Plásek; Jan Teisinger; Wilhelm Schoner; Evzen Amler
Phe(475) and Glu(446) but not Ser(445) participate in ATP-binding to the alpha-subunit of Na(+)/K(+)-ATPase.
Biochemical and biophysical research communications 2002;297(1):154-9.
2002: Wilhelm Schoner
Endogenous cardiac glycosides, a new class of steroid hormones.
European journal of biochemistry / FEBS 2002;269(10):2440-8.
2002: Wilhelm Schoner
Sodium pump and steroid hormone receptor. Na(+)/K(+)-ATPase.
European journal of biochemistry / FEBS 2002;269(10):2423.
2001: Georgios Scheiner-Bobis; Wilhelm Schoner
A fresh facet for ouabain action.
Nature medicine 2001;7(12):1288-9.
2001: Wilhelm Schoner
Endogenous cardiotonic steroids.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(2):273-80.
2000: R Antolovic; Natali B Bauer; M Mohadjerani; Holger Kost; Horst Neu; Ulrike Kirch; Ernst-Günther Grünbaum; Wilhelm Schoner
Endogenous ouabain and its binding globulin: effects of physical exercise and study on the globulin's tissue distribution.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23 Suppl():S93-8.
2000: Fabio Tanfani; Holger Linnertz; Tomas Obsil; Rita Krumscheid; P Urbanova; O Jelinek; Laura Mazzanti; Enrico Bertoli; Wilhelm Schoner; Evzen Amler
Effects of fluorescent pseudo-ATP and ATP-metal analogs on secondary structure of Na(+)/K(+)-ATPase.
Biochimica et biophysica acta 2000;1457(1-2):94-102.
2000: Wilhelm Schoner
Ouabain, a new steroid hormone of adrenal gland and hypothalamus.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2000;108(7):449-54.
1999: F Bernhardt; Wilhelm Schoner; B Schroeder; Gerhard Breves; Georgios Scheiner-Bobis
Functional expression and characterization of the wild-type mammalian renal cortex sodium/phosphate cotransporter and an 215R mutant in Saccharomyces cerevisiae.
Biochemistry 1999;38(41):13551-9.
1999: R Antolovic; E Hamer; E H Serpersu; Holger Kost; Holger Linnertz; Z Kovarik; Wilhelm Schoner
Affinity labelling with MgATP analogues reveals coexisting Na+ and K+ forms of the alpha-subunits of Na+/K+-ATPase.
European journal of biochemistry / FEBS 1999;261(1):181-9.
1999: D Thoenges; Evzen Amler; T Eckert; Wilhelm Schoner
Tight binding of bulky fluorescent derivatives of adenosine to the low affinity E2ATP site leads to inhibition of Na+/K+-ATPase. Analysis of structural requirements of fluorescent ATP derivatives with a Koshland-Némethy-Filmer model of two interacting ATP sites.
The Journal of biological chemistry 1999;274(4):1971-8.
1999: Holger Linnertz; E Lanz; Martin Gregor; R Antolovic; Rita Krumscheid; Tomas Obsil; J Slavik; Z Kovarik; Wilhelm Schoner; Evzen Amler
Microenvironment of the high affinity ATP-binding site of Na+/K+-ATPase is slightly acidic.
Biochemical and biophysical research communications 1999;254(1):215-21.
1998: Holger Linnertz; Holger Kost; Tomas Obsil; A Kotyk; Evzen Amler; Wilhelm Schoner
Erythrosin 5'-isothiocyanate labels Cys549 as part of the low-affinity ATP binding site of Na+/K+-ATPase.
FEBS letters 1998;441(1):103-5.
1998: Holger Linnertz; P Urbanova; Tomas Obsil; P Herman; Evzen Amler; Wilhelm Schoner
Molecular distance measurements reveal an (alpha beta)2 dimeric structure of Na+/K+-ATPase. High affinity ATP binding site and K+-activated phosphatase reside on different alpha-subunits.
The Journal of biological chemistry 1998;273(44):28813-21.
1998: R Schneider; R Antolovic; Holger Kost; B Sich; Ulrike Kirch; M Tepel; W Zidek; Wilhelm Schoner
Proscillaridin A immunoreactivity: its purification, transport in blood by a specific binding protein and its correlation with blood pressure.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(5-6):593-9.
1998: R Antolovic; Holger Kost; M Mohadjerani; Dietmar Linder; Monica Linder; Wilhelm Schoner
A specific binding protein for cardiac glycosides exists in bovine serum.
The Journal of biological chemistry 1998;273(26):16259-64.
1998: Wilhelm Schoner; W Mertens; M Helms; G Fortes
Binding of the Co(NH3)4 derivative of (2')3'-O-[N-methyl-anthraniloyl]-ATP to the E2ATP site of Na+/K+-transporting ATPase lowers the conformational flexibility of its E1ATP site.
European journal of biochemistry / FEBS 1998;253(1):245-50.
1998: Holger Linnertz; Ivan Miksik; P Kvasnicka; Enrico Bertoli; Laura Mazzanti; Wilhelm Schoner; Evzen Amler
Binding of pyrene isothiocyanate to the E1ATP site makes the H4-H5 cytoplasmic loop of Na+/K+-ATPase rigid.
European journal of biochemistry / FEBS 1998;251(1-2):522-7.
1998: R Schneider; Victor Wray; Manfred Nimtz; W D Lehmann; Ulrike Kirch; R Antolovic; Wilhelm Schoner
Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump.
The Journal of biological chemistry 1998;273(2):784-92.
1998: S Li; C Eim; Ulrike Kirch; R E Lang; Wilhelm Schoner
Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities.
Life sciences 1998;62(11):1023-33.
1997: S Q Li; C Eim; R Schneider; B Sich; Ulrike Kirch; Wilhelm Schoner
Proscillaridin A immunoreactivity: a new endogenous cardiac glycoside?
Annals of the New York Academy of Sciences 1997;834():646-7.
1997: R Antolovic; Holger Kost; Dietmar Linder; Monica Linder; D Thönges; D Lichtstein; Wilhelm Schoner
Demonstration of a specific transport protein for cardiac glycosides in bovine blood.
Annals of the New York Academy of Sciences 1997;834():618-20.
1997: D Thoenges; Holger Linnertz; Wilhelm Schoner
A two-site model of interacting ATP sites.
Annals of the New York Academy of Sciences 1997;834():322-6.
1997: K Brinkmann; Holger Linnertz; Evzen Amler; E Lanz; Petr Herman; Wilhelm Schoner
Fluoresceinyl-ethylenediamine-ouabain detects an acidic environment in the cardiac glycoside binding site of Na+/K+-ATPase.
European journal of biochemistry / FEBS 1997;249(1):301-8.
1997: D Thoenges; Wilhelm Schoner
2'-O-Dansyl analogs of ATP bind with high affinity to the low affinity ATP site of Na+/K+-ATPase and reveal the interaction of two ATP sites during catalysis.
The Journal of biological chemistry 1997;272(26):16315-21.
1997: Holger Linnertz; I Lastres Becker; Rita Krumscheid; Evzen Amler; D Thoenges; Wilhelm Schoner
2'(3')-O-[N- [2- [3- [5-fluoresceinyl] thioureido] ethyl] carbamoyl] adenosine 5'-triphosphate and its Cr(H2O)4 and Co(NH3)4 complex derivatives are new fluorescent tools for labelling ATP binding sites of Na+/K+-ATPase.
Physiological research / Academia Scientiarum Bohemoslovaca 1997;46(5):345-9.
1996: B Sich; Ulrike Kirch; M Tepel; W Zidek; Wilhelm Schoner
Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound.
Hypertension 1996;27(5):1073-8.
1995: Holger Linnertz; D Thönges; Wilhelm Schoner
Na+/K(+)-ATPase with a blocked E1ATP site still allows backdoor phosphorylation of the E2ATP site.
European journal of biochemistry / FEBS 1995;232(2):420-4.
1995: R Antolovic; Wilhelm Schoner; K Geering; Cecilia M Canessa; B C Rossier; Jean-Daniel Horisberger
Labeling of a cysteine in the cardiotonic glycoside binding site by the steroid derivative HDMA.
FEBS letters 1995;368(1):169-72.
1995: R Antolovic; Dietmar Linder; J Hahnen; Wilhelm Schoner
Affinity labeling of a sulfhydryl group in the cardiacglycoside receptor site of Na+/K(+)-ATPase by N-hydroxysuccinimidyl derivatives of digoxigenin.
European journal of biochemistry / FEBS 1995;227(1-2):61-7.
1994: C M Tran; Georgios Scheiner-Bobis; Wilhelm Schoner; Robert A Farley
Identification of an amino acid in the ATP binding site of Na+/K(+)-ATPase after photochemical labeling with 8-azido-ATP.
Biochemistry 1994;33(14):4140-7.
1994: Z M Rap; Wilhelm Schoner; Z Czernicki; G Hildebrandt; H W Mueller; Oskar Hoffmann
The endogenous ouabain-like sodium pump inhibitor in cold injury-induced brain edema.
Acta neurochirurgica. Supplementum 1994;60():98-100.
1993: E Hamer; Wilhelm Schoner
Modification of the E1ATP binding site of Na+/K(+)-ATPase by the chromium complex of adenosine 5'-[beta,gamma-methylene]triphosphate blocks the overall reaction but not the partial activities of the E2 conformation.
European journal of biochemistry / FEBS 1993;213(2):743-8.
1993: B Ahlemeyer; H Weintraut; Wilhelm Schoner
Extent of increase in intracellular calcium concentration in electrically stimulated chick embryo heart cells does not depend on resting intracellular calcium concentration.
Cardiology 1993;83(1-2):55-60.
1993: Wilhelm Schoner
Endogenous digitalis-like factors.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1993;41():249-91.
1993: Wilhelm Schoner; E Heidrich-Lorsbach; Ulrike Kirch; B Ahlemeyer; B Sich
Purification and properties of endogenous ouabain-like substances from hemofiltrate and adrenal glands.
Journal of cardiovascular pharmacology 1993;22 Suppl 2():S29-31.
1992: B Ahlemeyer; H Weintraut; Wilhelm Schoner
Cultured chick-embryo heart cells respond differently to ouabain as measured by the increase in their intracellular Na+ concentration.
Biochimica et biophysica acta 1992;1137(2):135-42.
1992: B Ahlemeyer; H Weintraut; Wilhelm Schoner
The regulation of the intracellular sodium ion concentration in cultured chick embryo heart cells.
Biochemical and biophysical research communications 1992;186(2):674-9.
1992: B Ahlemeyer; H Weintraut; Wilhelm Schoner
Chick embryo heart cells with high and low intracellular calcium concentrations respond differently to ouabain.
Biochimica et biophysica acta 1992;1136(1):91-8.
1992: B Ahlemeyer; H Weintraut; R Antolović; Wilhelm Schoner
Chick heart cells with high intracellular calcium concentration have a higher affinity for cardiac glycosides than those with low intracellular calcium concentration, as revealed by affinity labelling with a digoxigenin derivative.
European journal of biochemistry / FEBS 1992;205(1):269-75.
1992: E Buxbaum; Wilhelm Schoner
Investigation of subunit interactions by radiation inactivation: the case of Na+/K+-ATPase.
Journal of theoretical biology 1992;155(1):21-31.
1992: Georgios Scheiner-Bobis; W Mertens; M Willeke; Wilhelm Schoner
Synthesis and biochemical characterization of the new sulfhydryl-reactive ATP analogue 8-thiocyano-ATP. Its interaction with Na,K-ATPase and kinases.
Biochemistry 1992;31(7):2107-13.
1992: Wilhelm Schoner
Endogenous digitalis-like factors.
Clinical and experimental hypertension. Part A, Theory and practice 1992;14(5):767-814.
1991: R Antolovic; H J Brüller; S Bunk; Dietmar Linder; Wilhelm Schoner
Epitope mapping by amino-acid-sequence-specific antibodies reveals that both ends of the alpha subunit of Na+/K(+)-ATPase are located on the cytoplasmic side of the membrane.
European journal of biochemistry / FEBS 1991;199(1):195-202.
1991: Wilhelm Schoner
Endogenous digitalis-like factors.
Trends in pharmacological sciences 1991;12(6):209-11.
1991: E Buxbaum; Wilhelm Schoner
Phosphate binding and ATP-binding sites coexist in Na+/K(+)-transporting ATPase, as demonstrated by the inactivating MgPO4 complex analogue Co(NH3)4PO4.
European journal of biochemistry / FEBS 1991;195(2):407-19.
1990: E Buxbaum; Wilhelm Schoner
Blocking of Na+/K+ transport by the MgPO4 complex analogue Co(NH3)4PO4 leaves the Na+/Na(+)-exchange reaction of the sodium pump unaltered and shifts its high-affinity ATP-binding site to a Na(+)-like form.
European journal of biochemistry / FEBS 1990;193(2):355-60.
1990: M Rösler; Wilhelm Schoner
Antagonizing effects of phorbol 12-myristate 13-acetate on hormonally stimulated gluconeogenesis in isolated rat hepatocytes involve activity changes of pyruvate kinase.
Archives of biochemistry and biophysics 1990;281(2):185-90.
1990: E H Serpersu; S Bunk; Wilhelm Schoner
How do MgATP analogues differentially modify high-affinity and low-affinity ATP binding sites of Na+/K(+)-ATPase?
European journal of biochemistry / FEBS 1990;191(2):397-404.
1990: M Wenzel; E Heidrich; Ulrike Kirch; K Moreth-Wolfrat; V Wizemann; Wilhelm Schoner
Increased concentrations of a circulating sodium pump inhibitor in essential hypertension and uraemia and its partial purification from haemofiltrate.
Physiologia Bohemoslovaca 1990;39(1):79-85.
1989: E Skriver; Arvid B Maunsbach; Hans Hebert; Georgios Scheiner-Bobis; Wilhelm Schoner
Two-dimensional crystalline arrays of Na,K-ATPase with new subunit interactions induced by cobalt-tetrammine-ATP.
Journal of ultrastructure and molecular structure research 1989;102(3):189-95.
1989: Georgios Scheiner-Bobis; M Esmann; Wilhelm Schoner
Shift to the Na+ form of Na+/K+-transporting ATPase due to modification of the low-affinity ATP-binding site by Co(NH3)4ATP.
European journal of biochemistry / FEBS 1989;183(1):173-8.
1989: R Kison; H E Meyer; Wilhelm Schoner
Characterization of a cysteine-containing peptide after affinity labelling of Ca2+-ATPase of sarcoplasmic reticulum with the disulfide of 3'(2')-O-biotinyl-thioinosine triphosphate.
European journal of biochemistry / FEBS 1989;181(2):503-11.
1988: Georgios Scheiner-Bobis; E Buxbaum; Wilhelm Schoner
The catalytic subunits cooperate in (Na+ + K+)-ATPase: demonstration with MgPO4 and MgATP complex analogues.
Progress in clinical and biological research 1988;268A():219-26.
1988: Wilhelm Schoner; Georgios Scheiner-Bobis
Photoaffinity labeling with ATP analogs.
Methods in enzymology 1988;156():312-22.
1987: Georgios Scheiner-Bobis; K Fahlbusch; Wilhelm Schoner
Demonstration of cooperating alpha subunits in working (Na+ + K+)-ATPase by the use of the MgATP complex analogue cobalt tetrammine ATP.
European journal of biochemistry / FEBS 1987;168(1):123-31.
1987: Georgios Scheiner-Bobis; M Zimmermann; Ulrike Kirch; Wilhelm Schoner
Ouabain-binding site of (Na+ + K+)-ATPase in right-side-out vesicles has not an externally accessible SH group.
European journal of biochemistry / FEBS 1987;165(3):653-6.
1986: H Pauls; E H Serpersu; Ulrike Kirch; Wilhelm Schoner
Chromium(III)ATP inactivating (Na+ + K+)-ATPase supports Na+-Na+ and Rb+-Rb+ exchanges in everted red blood cells but not Na+,K+ transport.
European journal of biochemistry / FEBS 1986;157(3):585-95.
1985: Georgios Scheiner-Bobis; Wilhelm Schoner
Demonstration of an Mg2+-induced conformational change by photoaffinity labelling of the high-affinity ATP-binding site of (Na+ + K+)-ATPase with 8-azido-ATP.
European journal of biochemistry / FEBS 1985;152(3):739-46.
1982: E H Serpersu; Ulrike Kirch; Wilhelm Schoner
Demonstration of a stable occluded form of Ca2+ by the use of the chromium complex of ATP in the Ca2+-ATPase of sarcoplasmic reticulum.
European journal of biochemistry / FEBS 1982;122(2):347-54.
1980: H Pauls; B Bredenbröcker; Wilhelm Schoner
Inactivation of (Na+ + K+)-ATPase by chromium(III) complexes of nucleotide triphosphates.
European journal of biochemistry / FEBS 1980;109(2):523-33.