Lawrence Schopfer

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Grigoryan Hasmik; Li Bin; Xue Weihua; Grigoryan Marine; Schopfer Lawrence M; Lockridge Oksana
Mass spectral characterization of organophosphate-labeled lysine in peptides.
Gilley Cynthia; MacDonald Mary; Nachon Florian; Schopfer Lawrence M; Zhang Jun; Cashman John R; Lockridge Oksana
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
Grigoryan Hasmik; Schopfer Lawrence M; Peeples Eric S; Duysen Ellen G; Grigoryan Marine; Thompson Charles M; Lockridge Oksana
Mass spectrometry identifies multiple organophosphorylated sites on tubulin.

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2009: Grigoryan Hasmik; Li Bin; Xue Weihua; Grigoryan Marine; Schopfer Lawrence M; Lockridge Oksana
Mass spectral characterization of organophosphate-labeled lysine in peptides.
Analytical biochemistry 2009;394(1):92-100.
2009: Gilley Cynthia; MacDonald Mary; Nachon Florian; Schopfer Lawrence M; Zhang Jun; Cashman John R; Lockridge Oksana
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
Chemical research in toxicology 2009;22(10):1680-8.
2009: Grigoryan Hasmik; Schopfer Lawrence M; Peeples Eric S; Duysen Ellen G; Grigoryan Marine; Thompson Charles M; Lockridge Oksana
Mass spectrometry identifies multiple organophosphorylated sites on tubulin.
Toxicology and applied pharmacology 2009;240(2):149-58.
2009: Grigoryan Hasmik; Li Bin; Anderson Erica K; Xue Weihua; Nachon Florian; Lockridge Oksana; Schopfer Lawrence M
Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine.
Chemico-biological interactions 2009;180(3):492-8.
2009: Li He; Ricordel Ivan; Tong Larry; Schopfer Lawrence M; Baud Frédéric; Mégarbane Bruno; Maury Eric; Masson Patrick; Lockridge Oksana
Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum.
Journal of applied toxicology : JAT 2009;29(2):149-55.
2008: Carletti Eugénie; Li He; Li Bin; Ekström Fredrik; Nicolet Yvain; Loiodice Mélanie; Gillon Emilie; Froment Marie T; Lockridge Oksana; Schopfer Lawrence M; Masson Patrick; Nachon Florian
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.
Journal of the American Chemical Society 2008;130(47):16011-20.
2008: Ding Shi-Jian; Carr John; Carlson James E; Tong Larry; Xue Weihua; Li Yifeng; Schopfer Lawrence M; Li Bin; Nachon Florian; Asojo Oluwatoyin; Thompson Charles M; Hinrichs Steven H; Masson Patrick; Lockridge Oksana
Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Chemical research in toxicology 2008;21(9):1787-94.
2008: Li He; Tong Larry; Schopfer Lawrence M; Masson Patrick; Lockridge Oksana
Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase.
Chemico-biological interactions 2008;175(1-3):68-72.
2008: Masson Patrick; Nachon Florian; Broomfield Clarence A; Lenz David E; Verdier Laurent; Schopfer Lawrence M; Lockridge Oksana
A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.
Chemico-biological interactions 2008;175(1-3):273-80.
2008: Grigoryan Hasmik; Schopfer Lawrence M; Thompson Charles M; Terry Alvin V; Masson Patrick; Lockridge Oksana
Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.
Chemico-biological interactions 2008;175(1-3):180-6.
2008: Lockridge Oksana; Xue Weihua; Gaydess Andrea; Grigoryan Hasmik; Ding Shi-Jian; Schopfer Lawrence M; Hinrichs Steven H; Masson Patrick
Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines.
The Journal of biological chemistry 2008;283(33):22582-90.
2008: Masson Patrick; Froment Marie-Thérèse; Gillon Emilie; Nachon Florian; Lockridge Oksana; Schopfer Lawrence M
Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters.
The FEBS journal 2008;275(10):2617-31.
2008: Li He; Schopfer Lawrence M; Masson Patrick; Lockridge Oksana
Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers.
The Biochemical journal 2008;411(2):425-32.
2008: Mikami Liya R; Wieseler Stacy; Souza Ricardo L R; Schopfer Lawrence M; Nachon Florian; Lockridge Oksana; Chautard-Freire-Maia Eleidi A
Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.
Pharmacogenetics and genomics 2008;18(3):213-8.
2008: Li Bin; Nachon Florian; Froment Marie-Thérèse; Verdier Laurent; Debouzy Jean-Claude; Brasme Bernardo; Gillon Emilie; Schopfer Lawrence M; Lockridge Oksana; Masson Patrick
Binding and hydrolysis of soman by human serum albumin.
Chemical research in toxicology 2008;21(2):421-31.
2007: Li He; Schopfer Lawrence M; Nachon Florian; Froment Marie-Thérèse; Masson Patrick; Lockridge Oksana
Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):136-45.
2007: Mikami Liya R; Wieseler Stacy; Souza Ricardo L R; Schopfer Lawrence M; Lockridge Oksana; Chautard-Freire-Maia Eleidi A
Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.
Pharmacogenetics and genomics 2007;17(9):681-5.
2007: Masson Patrick; Froment Marie-Thérèse; Gillon Emilie; Nachon Florian; Darvesh Sultan; Schopfer Lawrence M
Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides.
Biochimica et biophysica acta 2007;1774(9):1139-47.
2007: Masson Patrick; Froment Marie-Thérèse; Darvesh Sultan; Schopfer Lawrence M; Lockridge Oksana
Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):463-9.
2007: Li Bin; Schopfer Lawrence M; Hinrichs Steven H; Masson Patrick; Lockridge Oksana
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.
Analytical biochemistry 2007;361(2):263-72.
2007: Masson Patrick; Froment Marie-Thérèse; Gillon Emilie; Nachon Florian; Lockridge Oksana; Schopfer Lawrence M
Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase.
Biochimica et biophysica acta 2007;1774(1):16-34.
2006: Poyot Thomas; Nachon Florian; Froment Marie-Thérèse; Loiodice Mélanie; Wieseler Stacy; Schopfer Lawrence M; Lockridge Oksana; Masson Patrick
Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters.
Biochimica et biophysica acta 2006;1764(9):1470-8.
2006: Wieseler Stacy; Schopfer Lawrence; Lockridge Oksana
Markers of organophosphate exposure in human serum.
Journal of molecular neuroscience : MN 2006;30(1-2):93-4.
2005: Li He; Schopfer Lawrence; Spaulding Reggie; Thompson Charles M; Lockridge Oksana
Identification of organophosphate-reactive proteins by tandem mass spectrometry.
Chemico-biological interactions 2005;157-158():383-4.
2005: Masson Patrick; Schopfer Lawrence M; Froment Marie-Thérèse; Debouzy Jean-Claude; Nachon Florian; Gillon Emilie; Lockridge Oksana; Hrabovska Anna; Goldstein Boris N
Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics.
Chemico-biological interactions 2005;157-158():143-52.
2005: Schopfer Lawrence M; Champion Matthew M; Tamblyn Nate; Thompson Charles M; Lockridge Oksana
Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410).
Analytical biochemistry 2005;345(1):122-32.
2005: Schopfer Lawrence M; Voelker Troy; Bartels Cynthia F; Thompson Charles M; Lockridge Oksana
Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase.
Chemical research in toxicology 2005;18(4):747-54.
2005: Peeples Eric S; Schopfer Lawrence M; Duysen Ellen G; Spaulding Reggie; Voelker Troy; Thompson Charles M; Lockridge Oksana
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(2):303-12.
2004: Wang Yuxia; Schopfer Lawrence M; Duysen Ellen G; Nachon Florian; Masson Patrick; Lockridge Oksana
Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants.
Analytical biochemistry 2004;329(1):131-8.
2004: Masson Patrick; Bec Nicole; Froment Marie-Thérèse; Nachon Florian; Balny Claude; Lockridge Oksana; Schopfer Lawrence M
Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior.
European journal of biochemistry / FEBS 2004;271(10):1980-90.
2004: Masson Patrick; Goldstein Boris N; Debouzy Jean-Claude; Froment Marie-Thérèse; Lockridge Oksana; Schopfer Lawrence M
Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate.
European journal of biochemistry / FEBS 2004;271(1):220-34.
2002: Boeck Andreea Ticu; Schopfer Lawrence M; Lockridge Oksana
DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase.
Biochemical pharmacology 2002;63(12):2101-10.
2002: Masson Patrick; Froment Marie Thérèse; Fort Sébastien; Ribes Fabien; Bec Nicole; Balny Claude; Schopfer Lawrence M
Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior.
Biochimica et biophysica acta 2002;1597(2):229-43.
2002: Masson Patrick; Schopfer Lawrence M; Bartels Cynthia F; Froment Marie-Thérèse; Ribes Fabien; Nachon Florian; Lockridge Oksana
Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite.
Biochimica et biophysica acta 2002;1594(2):313-24.
2001: Josse D; Lockridge O; Xie W; Bartels C F; Schopfer L M; Masson P
The active site of human paraoxonase (PON1).
Journal of applied toxicology : JAT 2001;21 Suppl 1():S7-11.
2001: Duysen E G; Li B; Xie W; Schopfer L M; Anderson R S; Broomfield C A; Lockridge O
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.
The Journal of pharmacology and experimental therapeutics 2001;299(2):528-35.
2001: Salhany J M; Schopfer L M
Kinetic mechanism of DIDS binding to band 3 (AE1) in human erythrocyte membranes.
Blood cells, molecules & diseases 2001;27(5):844-9.
2001: Sun H; El Yazal J; Lockridge O; Schopfer L M; Brimijoin S; Pang Y P
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
The Journal of biological chemistry 2001;276(12):9330-6.
2000: Li B; Stribley J A; Ticu A; Xie W; Schopfer L M; Hammond P; Brimijoin S; Hinrichs S H; Lockridge O
Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse.
Journal of neurochemistry 2000;75(3):1320-31.
2000: Bartels C F; Xie W; Miller-Lindholm A K; Schopfer L M; Lockridge O
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.
Biochemical pharmacology 2000;60(4):479-87.
1999: Josse D; Xie W; Masson P; Schopfer L M; Lockridge O
Tryptophan residue(s) as major components of the human serum paraoxonase active site.
Chemico-biological interactions 1999;119-120():79-84.
1999: Josse D; Xie W; Renault F; Rochu D; Schopfer L M; Masson P; Lockridge O
Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities.
Biochemistry 1999;38(9):2816-25.
1998: Schopfer L M; Salhany J M
Spectroscopic and kinetic characterization of eosin-5-maleimide.
Analytical biochemistry 1998;257(2):139-48.
1997: Masson P; Legrand P; Bartels C F; Froment M T; Schopfer L M; Lockridge O
Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.
Biochemistry 1997;36(8):2266-77.
1996: Salhany J M; Sloan R L; Schopfer L M
Characterization of the stilbenedisulphonate binding site on band 3 Memphis variant II (Pro-854-->Leu).
The Biochemical journal 1996;317 ( Pt 2)():509-14.
1996: Salhany J M; Schopfer L M
Interactions between mutant and wild-type band 3 subunits in hereditary Southeast Asian ovalocytic red blood cell membranes.
Biochemistry 1996;35(1):251-7.
1995: Salhany J M; Schopfer L M; Kay M M; Gamble D N; Lawrence C
Differential sensitivity of stilbenedisulfonates in their reaction with band 3 HT (Pro-868-->Leu).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11844-8.
1995: Schopfer L M; Salhany J M
Characterization of the stilbenedisulfonate binding site on band 3.
Biochemistry 1995;34(26):8320-9.
1994: Salhany J M; Sloan R L; Cordes K A; Schopfer L M
Kinetic evidence for ternary complex formation and allosteric interactions in chloride and stilbenedisulfonate binding to band 3.
Biochemistry 1994;33(39):11909-16.
1994: Guo L; Heinzinger N K; Stevenson M; Schopfer L M; Salhany J M
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
Antimicrobial agents and chemotherapy 1994;38(10):2483-7.
1994: Van Dort H M; Low P S; Cordes K A; Schopfer L M; Salhany J M
Calorimetric evidence for allosteric subunit interactions associated with inhibitor binding to band 3 transporter.
The Journal of biological chemistry 1994;269(1):59-61.
1993: Salhany J M; Cordes K A; Schopfer L M
Kinetics of conformational changes associated with inhibitor binding to the purified band 3 transporter. Direct observation of allosteric subunit interactions.
Biochemistry 1993;32(29):7413-20.
1993: Salhany J M; Schopfer L M
Pyridoxal 5'-phosphate binds specifically to soluble CD4 protein, the HIV-1 receptor. Implications for AIDS therapy.
The Journal of biological chemistry 1993;268(11):7643-5.
1992: Schopfer L M; Salhany J M
Factors determining the conformation and quaternary structure of isolated human erythrocyte band 3 in detergent solution.
Biochemistry 1992;31(50):12610-7.

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Lawrence Schopfer

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