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Gabriele Schramm

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Bart Everts; Helmut Haas; Cornelis H Hokke; Leonie Hussaarts; Moniek H J Meevissen; Markus Mohrs; Edward J Pearce; Thomas Scholzen; Gabriele Schramm; Hermelijn H Smits; Alwin J van der Ham; Barbara van der Hoeven; Sven Burgdorf; Nicole N Driessen; Maria Yazdanbakhsh
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
Moniek H J Meevissen; Gabriele Schramm; Hermelijn H Smits; Yvette van Kooyk; Sandra J van Vliet; Rick Versteegh; Maria Yazdanbakhsh; André M Deelder; Nicole N Driessen; Helmut Haas; Cornelis H Hokke
Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors.
Paola Zaccone; Oliver T Burton; Michael J Doenhoff; David W Dunne; Sarah E Gibbs; Helmut Haas; Frances M Jones; Nigel Miller; Gabriele Schramm; Anne Cooke
The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4⁺ T cells.

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All Publications

2012: Bart Everts; Helmut Haas; Cornelis H Hokke; Leonie Hussaarts; Moniek H J Meevissen; Markus Mohrs; Edward J Pearce; Thomas Scholzen; Gabriele Schramm; Hermelijn H Smits; Alwin J van der Ham; Barbara van der Hoeven; Sven Burgdorf; Nicole N Driessen; Maria Yazdanbakhsh
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
The Journal of experimental medicine 2012;209(10):1753-67, S1.
2012: Moniek H J Meevissen; Gabriele Schramm; Hermelijn H Smits; Yvette van Kooyk; Sandra J van Vliet; Rick Versteegh; Maria Yazdanbakhsh; André M Deelder; Nicole N Driessen; Helmut Haas; Cornelis H Hokke
Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors.
International journal for parasitology 2012;42(3):269-77.
2011: Paola Zaccone; Oliver T Burton; Michael J Doenhoff; David W Dunne; Sarah E Gibbs; Helmut Haas; Frances M Jones; Nigel Miller; Gabriele Schramm; Anne Cooke
The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4⁺ T cells.
European journal of immunology 2011;41(9):2709-18.
2011: Moniek H J Meevissen; Crina I A Balog; Carolien A M Koeleman; Michael J Doenhoff; Gabriele Schramm; Helmut Haas; André M Deelder; Manfred Wuhrer; Cornelis H Hokke
Targeted glycoproteomic analysis reveals that kappa-5 is a major, uniquely glycosylated component of Schistosoma mansoni egg antigens.
Molecular & cellular proteomics : MCP 2011;10(5):M110.005710.
2011: Ishwinder Kaur; Gabriele Schramm; Bart Everts; Thomas Scholzen; Karin B Kindle; Christian Beetz; Cristina Montiel-Duarte; Silke Blindow; Arwyn T Jones; Helmut Haas; Snjezana Stolnik; David M Heery; Franco Falcone
Interleukin-4-inducing principle from Schistosoma mansoni eggs contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake.
Infection and immunity 2011;79(4):1779-88.
2010: Gabriele Schramm; Helmut Haas
Th2 immune response against Schistosoma mansoni infection.
Microbes and infection / Institut Pasteur 2010;12(12-13):881-8.
2010: Moniek H J Meevissen; Manfred Wuhrer; Michael J Doenhoff; Gabriele Schramm; Helmut Haas; André M Deelder; Cornelis H Hokke
Structural characterization of glycans on omega-1, a major Schistosoma mansoni egg glycoprotein that drives Th2 responses.
Journal of proteome research 2010;9(5):2630-42.
2009: Bart Everts; Georgia Perona-Wright; Hermelijn H Smits; Cornelis H Hokke; Alwin J van der Ham; Colin M Fitzsimmons; Michael J Doenhoff; Jürgen van der Bosch; Katja Mohrs; Helmut Haas; Markus Mohrs; Maria Yazdanbakhsh; Gabriele Schramm
Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses.
The Journal of experimental medicine 2009;206(8):1673-80.
2009: Gabriele Schramm; J V Hamilton; C I A Balog; M Wuhrer; Achim Gronow; S Beckmann; Volker Wippersteg; Christoph G Grevelding; Torsten Goldmann; E Weber; N W Brattig; A M Deelder; D W Dunne; C H Hokke; Helmut Haas; Michael J Doenhoff
Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs.
Molecular and biochemical parasitology 2009;166(1):4-14.
2007: J Lin; N Renault; Helmut Haas; Gabriele Schramm; Stefan Vieths; Lothar Vogel; Franco Falcone; M J C Alcocer
A novel tool for the detection of allergic sensitization combining protein microarrays with human basophils.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(12):1854-62.
2007: Gabriele Schramm; Katja Mohrs; Maren Wodrich; Michael J Doenhoff; Edward J Pearce; Helmut Haas; Markus Mohrs
Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6023-7.
2006: Manfred Wuhrer; Crina I A Balog; M Isabel Catalina; Frances M Jones; Gabriele Schramm; Helmut Haas; Michael J Doenhoff; David W Dunne; André M Deelder; Cornelis H Hokke
IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans.
The FEBS journal 2006;273(10):2276-92.
2006: Gabriele Schramm; Achim Gronow; Jürgen Knobloch; Volker Wippersteg; Christoph G Grevelding; Jürgen Galle; heidi Fuller; Ronald G Stanley; P L Chiodini; Helmut Haas; Michael J Doenhoff
IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs.
Molecular and biochemical parasitology 2006;147(1):9-19.
2005: Colin M Fitzsimmons; Gabriele Schramm; Frances M Jones; Iain W Chalmers; Karl F Hoffmann; Christoph G Grevelding; Manfred Wuhrer; Cornelis H Hokke; Helmut Haas; Michael J Doenhoff; David W Dunne
Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.
Molecular and biochemical parasitology 2005;144(1):123-7.
2004: E Aumüller; Gabriele Schramm; Achim Gronow; K Brehm; Bernhard F Gibbs; Michael J Doenhoff; Helmut Haas
Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4.
Parasite immunology 2004;26(10):387-95.
2003: Gabriele Schramm; Franco Falcone; Achim Gronow; Karin Haisch; Uwe Mamat; Michael J Doenhoff; Guilherme Oliveira; Jürgen Galle; Clemens Dahinden; Helmut Haas
Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs.
The Journal of biological chemistry 2003;278(20):18384-92.
2003: Ute Lepp; Frank Eberhardt; Gabriele Schramm; Peter Zabel; Roland Suck; Hans Meyer; Helmut Fiebig; Oliver Cromwell; Wolf-Meinhard Becker
Approaches based on mutated or modified recombinant grass pollen allergens--in vivo evaluation of the constructs.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2003;(94):188-91.
2003: Oliver Cromwell; Helga Kahlert; Gabriele Schramm; Roland Suck; Andreas Nandy; Bernhard Weber; Helmut Fiebig
Mechanisms of immunotherapy with allergoids: lessons for the development of recombinant allergens with reduced IgE-binding activity.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2003;(94):156-61; discussion 161-2.
2001: Karin Haisch; Gabriele Schramm; Franco Falcone; C Alexander; MW Schlaak; Helmut Haas
A glycoprotein from Schistosoma mansoni eggs binds non-antigen-specific immunoglobulin E and releases interleukin-4 from human basophils.
Parasite immunology 2001;23(8):427-34.
2001: Gabriele Schramm; Albrecht Bufe; Arnd Petersen; Helmut Haas; R Merget; MW Schlaak; Wolf-Meinhard Becker
Discontinuous IgE-binding epitopes contain multiple continuous epitope regions: results of an epitope mapping on recombinant Hol l 5, a major allergen from velvet grass pollen.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(2):331-41.
1999: Helmut Haas; Franco Falcone; Martin Holland; Gabriele Schramm; Karin Haisch; Bernhard F Gibbs; Albrecht Bufe; MW Schlaak
Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy.
International archives of allergy and immunology 1999;119(2):86-94.
1999: Helmut Haas; Franco Falcone; Gabriele Schramm; Karin Haisch; Bernhard F Gibbs; J Klaucke; Marco Pöppelmann; Wolf-Meinhard Becker; Hans-Joachim Gabius; MW Schlaak
Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils.
European journal of immunology 1999;29(3):918-27.
1999: Gabriele Schramm; Helga Kahlert; Roland Suck; B Weber; HT Stüwe; WD Müller; Albrecht Bufe; Wolf-Meinhard Becker; MW Schlaak; L Jäger; Oliver Cromwell; Helmut Fiebig
"Allergen engineering": variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2406-14.
1999: Arnd Petersen; Kay Grobe; Gabriele Schramm; Stefan Vieths; Friedrich Altmann; MW Schlaak; Wolf-Meinhard Becker
Implications of the grass group I allergens on the sensitization and provocation process.
International archives of allergy and immunology 1999;118(2-4):411-3.
1998: Albrecht Bufe; Kirsten Gehlhar; Gabriele Schramm; MW Schlaak; Wolf-Meinhard Becker
Allergenic activity of a major grass pollen allergen is elevated in the presence of nasal secretion.
American journal of respiratory and critical care medicine 1998;157(4 Pt 1):1269-76.
1998: Arnd Petersen; Gabriele Schramm; MW Schlaak; Wolf-Meinhard Becker
Post-translational modifications influence IgE reactivity to the major allergen Phl p 1 of timothy grass pollen.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(3):315-21.
1998: Gabriele Schramm; Albrecht Bufe; Arnd Petersen; MW Schlaak; Wolf-Meinhard Becker
Molecular and immunological characterization of group V allergen isoforms from velvet grass pollen (Holcus lanatus).
European journal of biochemistry / FEBS 1998;252(2):200-6.
1997: Kirsten Gehlhar; Arnd Petersen; Gabriele Schramm; Wolf-Meinhard Becker; MW Schlaak; Albrecht Bufe
Investigation of different recombinant isoforms of grass group-V allergens (timothy grass pollen) isolated by low-stringency cDNA hybridization--antibody binding capacity and allergenic activity.
European journal of biochemistry / FEBS 1997;247(1):217-23.
1997: Gabriele Schramm; Albrecht Bufe; Arnd Petersen; Helmut Haas; MW Schlaak; Wolf-Meinhard Becker
Mapping of IgE-binding epitopes on the recombinant major group I allergen of velvet grass pollen, rHol l 1.
The Journal of allergy and clinical immunology 1997;99(6 Pt 1):781-7.
1996: Albrecht Bufe; Christian Betzel; Gabriele Schramm; Arnd Petersen; Wolf-Meinhard Becker; MW Schlaak; Markus Perbandt; Z Dauter; W Weber
Crystallization and preliminary diffraction data of a major pollen allergen. Crystal growth separates a low molecular weight form with elevated biological activity.
The Journal of biological chemistry 1996;271(44):27193-6.
1996: Albrecht Bufe; Gabriele Schramm
[Pathogenetic significance of IgE-binding epitopes allergens].
Pneumologie (Stuttgart, Germany) 1996;50(9):625-31.
1996: Gabriele Schramm; Arnd Petersen; Albrecht Bufe; MW Schlaak; Wolf-Meinhard Becker
Identification and characterization of the major allergens of velvet grass (Holcus lanatus), Hol l 1 and Hol l 5.
International archives of allergy and immunology 1996;110(4):354-63.
1996: Albrecht Bufe; Gabriele Schramm; Arnd Petersen; MW Schlaak; Wolf-Meinhard Becker
The function of allergens may determine allergenicity.
Advances in experimental medicine and biology 1996;409():399-402.
1995: Arnd Petersen; Albrecht Bufe; Gabriele Schramm; MW Schlaak; Wolf-Meinhard Becker
Characterization of the allergen group VI in timothy grass pollen (Phl p 6). II. cDNA cloning of Phl p 6 and structural comparison to grass group V.
International archives of allergy and immunology 1995;108(1):55-9.
1995: Arnd Petersen; Gabriele Schramm; Albrecht Bufe; MW Schlaak; Wolf-Meinhard Becker
Structural investigations of the major allergen Phl p I on the complementary DNA and protein level.
The Journal of allergy and clinical immunology 1995;95(5 Pt 1):987-94.
1995: Albrecht Bufe; Gabriele Schramm; M B Keown; MW Schlaak; Wolf-Meinhard Becker
Major allergen Phl p Vb in timothy grass is a novel pollen RNase.
FEBS letters 1995;363(1-2):6-12.
1994: Albrecht Bufe; Wolf-Meinhard Becker; Gabriele Schramm; Arnd Petersen; U Mamat; MW Schlaak
Major allergen Phl p Va (timothy grass) bears at least two different IgE-reactive epitopes.
The Journal of allergy and clinical immunology 1994;94(2 Pt 1):173-81.