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Vern Schramm

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Azotobacter

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Co-Publications
Name
53
Tyler, Peter
45
Furneaux, Richard
34
Evans, Gary
22
Almo, Steven
15
Shi, Wuxian
13
Singh, Vipender
13
Lewandowicz, Andrzej
9
Kicska, Gregory
9
Murkin, Andrew
9
Luo, Minkui
8
Sauve, Anthony
8
Kim, Kami
7
Li, Lei
7
Clinch, Keith
7
Schwartz, Steven

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Publications

TOP 3
Riegelhaupt Paul M; Cassera María B; Fröhlich Richard F G; Hazleton Keith Z; Hefter Jonathan J; Schramm Vern L; Akabas Myles H
Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
Schramm Vern L
Transition States.
Sturm Matthew B; Tyler Peter C; Evans Gary B; Schramm Vern L
Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein.

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All Publications

2010: Riegelhaupt Paul M; Cassera María B; Fröhlich Richard F G; Hazleton Keith Z; Hefter Jonathan J; Schramm Vern L; Akabas Myles H
Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
Molecular and biochemical parasitology 2010;169(1):40-9.
2009: Schramm Vern L
Transition States.
The Journal of biological chemistry 2009;284(47):32201-8.
2009: Sturm Matthew B; Tyler Peter C; Evans Gary B; Schramm Vern L
Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein.
Biochemistry 2009;48(41):9941-8.
2009: Ho Meng-Chiao; Cassera María B; Madrid Dennis C; Ting Li-Min; Tyler Peter C; Kim Kami; Almo Steven C; Schramm Vern L
Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Biochemistry 2009;48(40):9618-26.
2009: Ghanem Mahmoud; Murkin Andrew S; Schramm Vern L
Ribocation transition state capture and rebound in human purine nucleoside phosphorylase.
Chemistry & biology 2009;16(9):971-9.
2009: Burgos Emmanuel S; Ho Meng-Chiao; Almo Steven C; Schramm Vern L
A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13748-53.
2009: Schwartz Steven D; Schramm Vern L
Enzymatic transition states and dynamic motion in barrier crossing.
Nature chemical biology 2009;5(8):551-8.
2009: Edwards Achelle A; Mason Jennifer M; Clinch Keith; Tyler Peter C; Evans Gary B; Schramm Vern L
Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase.
Biochemistry 2009;48(23):5226-38.
2009: Sturm Matthew B; Schramm Vern L
Detecting ricin: sensitive luminescent assay for ricin A-chain ribosome depurination kinetics.
Analytical chemistry 2009;81(8):2847-53.
2009: Zhang Yong; Luo Minkui; Schramm Vern L
Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.
Journal of the American Chemical Society 2009;131(13):4685-94.
2009: Gutierrez Jemy A; Crowder Tamara; Rinaldo-Matthis Agnes; Ho Meng-Chiao; Almo Steven C; Schramm Vern L
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Nature chemical biology 2009;5(4):251-7.
2009: Ghanem Mahmoud; Zhadin Nickolay; Callender Robert; Schramm Vern L
Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics.
Biochemistry 2009;48(16):3658-68.
2009: Clinch Keith; Evans Gary B; Fröhlich Richard F G; Furneaux Richard H; Kelly Peter M; Legentil Laurent; Murkin Andrew S; Li Lei; Schramm Vern L; Tyler Peter C; Woolhouse Anthony D
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.
Journal of medicinal chemistry 2009;52(4):1126-43.
2008: Madrid Dennis C; Ting Li-Min; Waller Karena L; Schramm Vern L; Kim Kami
Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites.
The Journal of biological chemistry 2008;283(51):35899-907.
2008: Cassera María B; Hazleton Keith Z; Riegelhaupt Paul M; Merino Emilio F; Luo Minkui; Akabas Myles H; Schramm Vern L
Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.
The Journal of biological chemistry 2008;283(47):32889-99.
2008: Murkin Andrew S; Clinch Keith; Mason Jennifer M; Tyler Peter C; Schramm Vern L
Immucillins in custom catalytic-site cavities.
Bioorganic & medicinal chemistry letters 2008;18(22):5900-3.
2008: Saen-Oon Suwipa; Quaytman-Machleder Sara; Schramm Vern L; Schwartz Steven D
Atomic detail of chemical transformation at the transition state of an enzymatic reaction.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16543-8.
2008: Burgos Emmanuel S; Schramm Vern L
Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase.
Biochemistry 2008;47(42):11086-96.
2008: Mason Jennifer M; Murkin Andrew S; Li Lei; Schramm Vern L; Gainsford Graeme J; Skelton Brian W
A beta-fluoroamine inhibitor of purine nucleoside phosphorylase.
Journal of medicinal chemistry 2008;51(18):5880-4.
2008: Hawse William F; Hoff Kevin G; Fatkins David G; Daines Alison; Zubkova Olga V; Schramm Vern L; Zheng Weiping; Wolberger Cynthia
Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure (London, England : 1993) 2008;16(9):1368-77.
2008: Luo Minkui; Schramm Vern L
Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-(2)H kinetic isotope effect.
Journal of the American Chemical Society 2008;130(35):11617-9.
2008: Huang Min; Wang Yanhong; Gu Jingjin; Yang Jing; Noel Karen; Mitchell Beverly S; Schramm Vern L; Graves Lee M
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H.
Leukemia research 2008;32(8):1268-78.
2008: Saen-Oon Suwipa; Ghanem Mahmoud; Schramm Vern L; Schwartz Steven D
Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase.
Biophysical journal 2008;94(10):4078-88.
2008: Roday Setu; Sturm Matthew B; Blakaj Dukajgin; Schramm Vern L
Detection of an abasic site in RNA with stem-loop DNA beacons: application to an activity assay for Ricin Toxin A-Chain.
Journal of biochemical and biophysical methods 2008;70(6):945-53.
2008: Ghanem Mahmoud; Saen-oon Suwipa; Zhadin Nickolay; Wing Corin; Cahill Sean M; Schwartz Steven D; Callender Robert; Schramm Vern L
Tryptophan-free human PNP reveals catalytic site interactions.
Biochemistry 2008;47(10):3202-15.
2008: Li Lei; Luo Minkui; Ghanem Mahmoud; Taylor Erika A; Schramm Vern L
Second-sphere amino acids contribute to transition-state structure in bovine purine nucleoside phosphorylase.
Biochemistry 2008;47(8):2577-83.
2008: Luo Minkui; Li Lei; Schramm Vern L
Remote mutations alter transition-state structure of human purine nucleoside phosphorylase.
Biochemistry 2008;47(8):2565-76.
2008: Ghanem Mahmoud; Li Lei; Wing Corin; Schramm Vern L
Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase.
Biochemistry 2008;47(8):2559-64.
2008: Evans Gary B; Furneaux Richard H; Greatrex Ben; Murkin Andrew S; Schramm Vern L; Tyler Peter C
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
Journal of medicinal chemistry 2008;51(4):948-56.
2008: Luo Minkui; Schramm Vern L
Transition state structure of E. coli tRNA-specific adenosine deaminase.
Journal of the American Chemical Society 2008;130(8):2649-55.
2008: Murkin Andrew S; Tyler Peter C; Schramm Vern L
Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects.
Journal of the American Chemical Society 2008;130(7):2166-7.
2008: Rinaldo-Matthis Agnes; Murkin Andrew S; Ramagopal Udupi A; Clinch Keith; Mee Simon P H; Evans Gary B; Tyler Peter C; Furneaux Richard H; Almo Steven C; Schramm Vern L
L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.
Journal of the American Chemical Society 2008;130(3):842-4.
2008: Mundt Janna M; Hah Sang Soo; Sumbad Rhoda A; Schramm Vern; Henderson Paul T
Incorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells.
Nucleic acids research 2008;36(1):228-36.
2008: Schramm Vern L; Gutierrez Jemy A; Cordovano Grace; Basu Indranil; Guha Chandan; Belbin Thomas J; Evans Gary B; Tyler Peter C; Furneaux Richard H
Transition state analogues in quorum sensing and SAM recycling.
Nucleic acids symposium series (2004) 2008;(52):75-6.
2007: Gutierrez Jemy A; Luo Minkui; Singh Vipender; Li Lei; Brown Rosemary L; Norris Gillian E; Evans Gary B; Furneaux Richard H; Tyler Peter C; Painter Gavin F; Lenz Dirk H; Schramm Vern L
Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.
ACS chemical biology 2007;2(11):725-34.
2007: Singh Vipender; Luo Minkui; Brown Rosemary L; Norris Gillian E; Schramm Vern L
Transition-state structure of neisseria meningitides 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Journal of the American Chemical Society 2007;129(45):13831-3.
2007: Taylor Erika A; Rinaldo-Matthis Agnes; Li Lei; Ghanem Mahmoud; Hazleton Keith Z; Cassera María B; Almo Steven C; Schramm Vern L
Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition.
Biochemistry 2007;46(43):12405-15.
2007: Schramm Vern L
Binding isotope effects: boon and bane.
Current opinion in chemical biology 2007;11(5):529-36.
2007: Schramm Vern L
Enzymatic transition state theory and transition state analogue design.
The Journal of biological chemistry 2007;282(39):28297-300.
2007: Basu Indranil; Cordovano Grace; Das Ishita; Belbin Thomas J; Guha Chandan; Schramm Vern L
A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers.
The Journal of biological chemistry 2007;282(29):21477-86.
2007: Luo Minkui; Singh Vipender; Taylor Erika A; Schramm Vern L
Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases.
Journal of the American Chemical Society 2007;129(25):8008-17.
2007: Taylor Erika A; Clinch Keith; Kelly Peter M; Li Lei; Evans Gary B; Tyler Peter C; Schramm Vern L
Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases.
Journal of the American Chemical Society 2007;129(22):6984-5.
2007: Tyler Peter C; Taylor Erika A; Fröhlich Richard F G; Schramm Vern L
Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase.
Journal of the American Chemical Society 2007;129(21):6872-9.
2007: Roday Setu; Saen-oon Suwipa; Schramm Vern L
Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin a-chain.
Biochemistry 2007;46(21):6169-82.
2007: Sturm Matthew B; Roday Setu; Schramm Vern L
Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design.
Journal of the American Chemical Society 2007;129(17):5544-50.
2007: Murkin Andrew S; Birck Matthew R; Rinaldo-Matthis Agnes; Shi Wuxian; Taylor Erika A; Almo Steven C; Schramm Vern L
Neighboring group participation in the transition state of human purine nucleoside phosphorylase.
Biochemistry 2007;46(17):5038-49.
2007: Singh Vipender; Schramm Vern L
Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase.
Journal of the American Chemical Society 2007;129(10):2783-95.
2007: Rinaldo-Matthis Agnes; Wing Corin; Ghanem Mahmoud; Deng Hua; Wu Peng; Gupta Arti; Tyler Peter C; Evans Gary B; Furneaux Richard H; Almo Steven C; Wang Ching C; Schramm Vern L
Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
Biochemistry 2007;46(3):659-68.
2007: Evans Gary B; Furneaux Richard H; Kelly Peter M; Schramm Vern L; Tyler Peter C
Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.
Nucleic acids symposium series (2004) 2007;(51):63-4.
2006: Singh Vipender; Schramm Vern L
Transition-state structure of human 5'-methylthioadenosine phosphorylase.
Journal of the American Chemical Society 2006;128(45):14691-6.
2006: Singh Vipender; Shi Wuxian; Almo Steven C; Evans Gary B; Furneaux Richard H; Tyler Peter C; Painter Gavin F; Lenz Dirk H; Mee Simon; Zheng Renjian; Schramm Vern L
Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
Biochemistry 2006;45(43):12929-41.
2006: Chattopadhyay Shrikanta; Zhao Rongbao; Tsai Eugenia; Schramm Vern L; Goldman I David
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Molecular cancer therapeutics 2006;5(10):2549-55.
2006: Deng Hua; Murkin Andrew S; Schramm Vern L
Phosphate activation in the ground state of purine nucleoside phosphorylase.
Journal of the American Chemical Society 2006;128(24):7765-71.
2006: Taylor Ringia Erika A; Tyler Peter C; Evans Gary B; Furneaux Richard H; Murkin Andrew S; Schramm Vern L
Transition state analogue discrimination by related purine nucleoside phosphorylases.
Journal of the American Chemical Society 2006;128(22):7126-7.
2006: Kim Jungwook; Malashkevich Vladimir; Roday Setu; Lisbin Michael; Schramm Vern L; Almo Steven C
Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase.
Biochemistry 2006;45(20):6407-16.
2006: Lewis Brett E; Choytun Nankishoresing; Schramm Vern L; Bennet Andrew J
Transition states for glucopyranose interconversion.
Journal of the American Chemical Society 2006;128(15):5049-58.
2006: Clinch Keith; Evans Gary B; Fleet George W J; Furneaux Richard H; Johnson Stephen W; Lenz Dirk H; Mee Simon P H; Rands Peter R; Schramm Vern L; Taylor Ringia Erika A; Tyler Peter C
Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.
Organic & biomolecular chemistry 2006;4(6):1131-9.
2006: Núñez Sara; Wing Corin; Antoniou Dimitri; Schramm Vern L; Schwartz Steven D
Insight into catalytically relevant correlated motions in human purine nucleoside phosphorylase.
The journal of physical chemistry. A 2006;110(2):463-72.
2006: Sauve Anthony A; Wolberger Cynthia; Schramm Vern L; Boeke Jef D
The biochemistry of sirtuins.
Annual review of biochemistry 2006;75():435-65.
2005: Schramm Vern L
Enzymatic transition states and transition state analogues.
Current opinion in structural biology 2005;15(6):604-13.
2005: Singh Vipender; Lee Jeffrey E; Núñez Sara; Howell P Lynne; Schramm Vern L
Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.
Biochemistry 2005;44(35):11647-59.
2005: Lewandowicz Andrzej; Ringia Erika A Taylor; Ting Li-Min; Kim Kami; Tyler Peter C; Evans Gary B; Zubkova Olga V; Mee Simon; Painter Gavin F; Lenz Dirk H; Furneaux Richard H; Schramm Vern L
Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.
The Journal of biological chemistry 2005;280(34):30320-8.
2005: Evans Gary B; Furneaux Richard H; Lenz Dirk H; Painter Gavin F; Schramm Vern L; Singh Vipender; Tyler Peter C
Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.
Journal of medicinal chemistry 2005;48(14):4679-89.
2005: Singh Vipender; Evans Gary B; Lenz Dirk H; Mason Jennifer M; Clinch Keith; Mee Simon; Painter Gavin F; Tyler Peter C; Furneaux Richard H; Lee Jeffrey E; Howell P Lynne; Schramm Vern L
Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.
The Journal of biological chemistry 2005;280(18):18265-73.
2005: Lee Jeffrey E; Singh Vipender; Evans Gary B; Tyler Peter C; Furneaux Richard H; Cornell Kenneth A; Riscoe Michael K; Schramm Vern L; Howell P Lynne
Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
The Journal of biological chemistry 2005;280(18):18274-82.
2005: Amukele Tim K; Roday Setu; Schramm Vern L
Ricin A-chain activity on stem-loop and unstructured DNA substrates.
Biochemistry 2005;44(11):4416-25.
2005: Ting Li-Min; Shi Wuxian; Lewandowicz Andrzej; Singh Vipender; Mwakingwe Agnes; Birck Matthew R; Ringia Erika A Taylor; Bench Graham; Madrid Dennis C; Tyler Peter C; Evans Gary B; Furneaux Richard H; Schramm Vern L; Kim Kami
Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins.
The Journal of biological chemistry 2005;280(10):9547-54.
2005: Sauve Anthony A; Moir Robyn D; Schramm Vern L; Willis Ian M
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
Molecular cell 2005;17(4):595-601.
2005: Schramm Vern L
Enzymatic transition states: thermodynamics, dynamics and analogue design.
Archives of biochemistry and biophysics 2005;433(1):13-26.
2005: Taylor Ringia Erika A; Schramm Vern L
Transition states and inhibitors of the purine nucleoside phosphorylase family.
Current topics in medicinal chemistry 2005;5(13):1237-58.
2004: Deng Hua; Cahill Sean M; Abad José-Luis; Lewandowicz Andrzej; Callender Robert H; Schramm Vern L; Jones Roger A
Active site contacts in the purine nucleoside phosphorylase--hypoxanthine complex by NMR and ab initio calculations.
Biochemistry 2004;43(50):15966-74.
2004: Núñez Sara; Antoniou Dimitri; Schramm Vern L; Schwartz Steven D
Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study.
Journal of the American Chemical Society 2004;126(48):15720-9.
2004: Schramm Vern L
Immucillins as antibiotics for T-cell proliferation and malaria.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1305-11.
2004: Deng Hua; Lewandowicz Andrzej; Schramm Vern L; Callender Robert
Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study.
Journal of the American Chemical Society 2004;126(31):9516-7.
2004: Birck Matthew R; Schramm Vern L
Binding causes the remote [5'-3H]thymidine kinetic isotope effect in human thymidine phosphorylase.
Journal of the American Chemical Society 2004;126(22):6882-3.
2004: Evans Gary B; Furneaux Richard H; Schramm Vern L; Singh Vipender; Tyler Peter C
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
Journal of medicinal chemistry 2004;47(12):3275-81.
2004: Zhou Guo-Chun; Parikh Sapan L; Tyler Peter C; Evans Gary B; Furneaux Richard H; Zubkova Olga V; Benjes Paul A; Schramm Vern L
Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states.
Journal of the American Chemical Society 2004;126(18):5690-8.
2004: Roday Setu; Amukele Timothy; Evans Gary B; Tyler Peter C; Furneaux Richard H; Schramm Vern L
Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.
Biochemistry 2004;43(17):4923-33.
2004: Amukele Tim K; Schramm Vern L
Ricin A-chain substrate specificity in RNA, DNA, and hybrid stem-loop structures.
Biochemistry 2004;43(17):4913-22.
2004: Sauve Anthony A; Schramm Vern L
SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates.
Current medicinal chemistry 2004;11(7):807-26.
2004: Shi Wuxian; Ting Li-Min; Kicska Gregory A; Lewandowicz Andrzej; Tyler Peter C; Evans Gary B; Furneaux Richard H; Kim Kami; Almo Steve C; Schramm Vern L
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
The Journal of biological chemistry 2004;279(18):18103-6.
2004: Birck Matthew R; Schramm Vern L
Nucleophilic participation in the transition state for human thymidine phosphorylase.
Journal of the American Chemical Society 2004;126(8):2447-53.
2004: Deng Hua; Lewandowicz Andrzej; Cahill Sean M; Furneaux Richard H; Tyler Peter C; Girvin Mark E; Callender Robert H; Schramm Vern L
Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs.
Biochemistry 2004;43(7):1980-7.
2004: Lewandowicz Andrzej; Schramm Vern L
Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.
Biochemistry 2004;43(6):1458-68.
2004: Parikh Sapan L; Schramm Vern L
Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin.
Biochemistry 2004;43(5):1204-12.
2004: Singh Vipender; Shi Wuxian; Evans Gary B; Tyler Peter C; Furneaux Richard H; Almo Steven C; Schramm Vern L
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
Biochemistry 2004;43(1):9-18.
2004: Schramm Vern L; Grubmeyer Charles
Phosphoribosyltransferase mechanisms and roles in nucleic acid metabolism.
Progress in nucleic acid research and molecular biology 2004;78():261-304.
2003: Kicska Gregory A; Ting Li-Min; Schramm Vern L; Kim Kami
Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infection.
The Journal of infectious diseases 2003;188(11):1776-81.
2003: Evans Gary B; Furneaux Richard H; Lewandowicz Andrzej; Schramm Vern L; Tyler Peter C
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.
Journal of medicinal chemistry 2003;46(24):5271-6.
2003: Evans Gary B; Furneaux Richard H; Tyler Peter C; Schramm Vern L
Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction.
Organic letters 2003;5(20):3639-40.
2003: Schramm Vern L
Enzymatic transition state poise and transition state analogues.
Accounts of chemical research 2003;36(8):588-96.
2003: Sauve Anthony A; Schramm Vern L
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.
Biochemistry 2003;42(31):9249-56.
2003: Lewandowicz Andrzej; Tyler Peter C; Evans Gary B; Furneaux Richard H; Schramm Vern L
Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase.
The Journal of biological chemistry 2003;278(34):31465-8.
2003: Evans Gary B; Furneaux Richard H; Lewandowicz Andrzej; Schramm Vern L; Tyler Peter C
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
Journal of medicinal chemistry 2003;46(15):3412-23.
2003: Lewis Brett E; Schramm Vern L
Isotope effect-mapping of the ionization of glucose demonstrates unusual charge sharing.
Journal of the American Chemical Society 2003;125(26):7872-7.
2003: Lewandowicz Andrzej; Shi Wuxian; Evans Gary B; Tyler Peter C; Furneaux Richard H; Basso Luiz A; Santos Diogenes S; Almo Steven C; Schramm Vern L
Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.
Biochemistry 2003;42(20):6057-66.
2003: Sauve Anthony A; Cahill Sean M; Zech Stephan G; Basso Luiz A; Lewandowicz Andrzej; Santos Diogenes S; Grubmeyer Charles; Evans Gary B; Furneaux Richard H; Tyler Peter C; McDermott Ann; Girvin Mark E; Schramm Vern L
Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.
Biochemistry 2003;42(19):5694-705.
2003: Lewis Brett E; Schramm Vern L
Binding equilibrium isotope effects for glucose at the catalytic domain of human brain hexokinase.
Journal of the American Chemical Society 2003;125(16):4785-98.
2003: Lewis Brett E; Schramm Vern L
Glucose binding isotope effects in the ternary complex of brain hexokinase demonstrate partial relief of ground-state destabilization.
Journal of the American Chemical Society 2003;125(16):4672-3.
2003: Evans Gary B; Furneaux Richard H; Gainsford Graeme J; Hanson John C; Kicska Gregory A; Sauve Antony A; Schramm Vern L; Tyler Peter C
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.
Journal of medicinal chemistry 2003;46(1):155-60.
2003: Schramm Vern L
Transition state analogues for enzymes of nucleic acid metabolism.
Nucleic acids research. Supplement (2001) 2003;(3):107-8.
2003: Schramm Vern L; Tyler Peter C
Imino-sugar-based nucleosides.
Current topics in medicinal chemistry 2003;3(5):525-40.
2002: Kicska Greg A; Tyler Peter C; Evans Gary B; Furneaux Richard H; Shi Wuxian; Fedorov Alexander; Lewandowicz Andrzej; Cahill Sean M; Almo Steven C; Schramm Vern L
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.
Biochemistry 2002;41(49):14489-98.
2002: Shi Wuxian; Sarver Anne E; Wang Ching C; Tanaka Kelly S E; Almo Steven C; Schramm Vern L
Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration.
The Journal of biological chemistry 2002;277(42):39981-8.
2002: Schramm Vern L
Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents.
Biochimica et biophysica acta 2002;1587(2-3):107-17.
2002: Sauve Anthony A; Schramm Vern L
Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase.
Biochemistry 2002;41(26):8455-63.
2002: Kicska Gregory A; Tyler Peter C; Evans Gary B; Furneaux Richard H; Kim Kami; Schramm Vern L
Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum.
The Journal of biological chemistry 2002;277(5):3219-25.
2002: Kicska Gregory A; Tyler Peter C; Evans Gary B; Furneaux Richard H; Schramm Vern L; Kim Kami
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
The Journal of biological chemistry 2002;277(5):3226-31.
2001: Schramm V L; Shi W
Atomic motion in enzymatic reaction coordinates.
Current opinion in structural biology 2001;11(6):657-65.
2001: Sauve A A; Celic I; Avalos J; Deng H; Boeke J D; Schramm V L
Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions.
Biochemistry 2001;40(51):15456-63.
2001: Schramm V L
Transition state variation in enzymatic reactions.
Current opinion in chemical biology 2001;5(5):556-63.
2001: Shi W; Tanaka K S; Crother T R; Taylor M W; Almo S C; Schramm V L
Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.
Biochemistry 2001;40(36):10800-9.
2001: Evans G B; Furneaux R H; Hutchison T L; Kezar H S; Morris P E; Schramm V L; Tyler P C
Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.
The Journal of organic chemistry 2001;66(17):5723-30.
2001: Shi W; Basso L A; Santos D S; Tyler P C; Furneaux R H; Blanchard J S; Almo S C; Schramm V L
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry 2001;40(28):8204-15.
2001: Basso L A; Santos D S; Shi W; Furneaux R H; Tyler P C; Schramm V L; Blanchard J S
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
Biochemistry 2001;40(28):8196-203.
2001: Wang F; Shi W; Nieves E; Angeletti R H; Schramm V L; Grubmeyer C
A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase.
Biochemistry 2001;40(27):8043-54.
2001: Tanaka K S; Chen X Y; Ichikawa Y; Tyler P C; Furneaux R H; Schramm V L
Ricin A-chain inhibitors resembling the oxacarbenium ion transition state.
Biochemistry 2001;40(23):6845-51.
2001: Kicska G A; Long L; Hörig H; Fairchild C; Tyler P C; Furneaux R H; Schramm V L; Kaufman H L
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4593-8.
2001: Lewis B E; Schramm V L
Conformational equilibrium isotope effects in glucose by (13)C NMR spectroscopy and computational studies.
Journal of the American Chemical Society 2001;123(7):1327-36.
2001: Fedorov A; Shi W; Kicska G; Fedorov E; Tyler P C; Furneaux R H; Hanson J C; Gainsford G J; Larese J Z; Schramm V L; Almo S C
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.
Biochemistry 2001;40(4):853-60.
2001: LoBrutto R; Bandarian V; Magnusson O T; Chen X; Schramm V L; Reed G H
5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies.
Biochemistry 2001;40(1):9-14.
2000: Wang F; Miles R W; Kicska G; Nieves E; Schramm V L; Angeletti R H
Immucillin-H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange.
Protein science : a publication of the Protein Society 2000;9(9):1660-8.
2000: Shi W; Munagala N R; Wang C C; Li C M; Tyler P C; Furneaux R H; Grubmeyer C; Schramm V L; Almo S C
Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Biochemistry 2000;39(23):6781-90.
1999: Braunheim B B; Miles R W; Schramm V L; Schwartz S D
Prediction of inhibitor binding free energies by quantum neural networks. Nucleoside analogues binding to trypanosomal nucleoside hydrolase.
Biochemistry 1999;38(49):16076-83.
1999: Furneaux R H; Schramm V L; Tyler P C
Transition state analogue inhibitors of protozoan nucleoside hydrolases.
Bioorganic & medicinal chemistry 1999;7(11):2599-606.
1999: Miles R W; Tyler P C; Evans G B; Furneaux R H; Parkin D W; Schramm V L
Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases.
Biochemistry 1999;38(40):13147-54.
1999: Shi W; Li C M; Tyler P C; Furneaux R H; Cahill S M; Girvin M E; Grubmeyer C; Schramm V L; Almo S C
The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
Biochemistry 1999;38(31):9872-80.
1999: Shi W; Schramm V L; Almo S C
Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-å crystal structure.
The Journal of biological chemistry 1999;274(30):21114-20.
1999: Shi W; Li C M; Tyler P C; Furneaux R H; Grubmeyer C; Schramm V L; Almo S C
The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
Nature structural biology 1999;6(6):588-93.
1999: Li C M; Tyler P C; Furneaux R H; Kicska G; Xu Y; Grubmeyer C; Girvin M E; Schramm V L
Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.
Nature structural biology 1999;6(6):582-7.
1999: Schramm V L
Enzymatic transition-state analysis and transition-state analogs.
Methods in enzymology 1999;308():301-55.
1998: Sauve A A; Munshi C; Lee H C; Schramm V L
The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries.
Biochemistry 1998;37(38):13239-49.
1998: Chen X Y; Link T M; Schramm V L
Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors.
Biochemistry 1998;37(33):11605-13.
1998: Miles R W; Tyler P C; Furneaux R H; Bagdassarian C K; Schramm V L
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
Biochemistry 1998;37(24):8615-21.
1998: Degano M; Almo S C; Sacchettini J C; Schramm V L
Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.
Biochemistry 1998;37(18):6277-85.
1998: Scheuring J; Berti P J; Schramm V L
Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin.
Biochemistry 1998;37(9):2748-58.
1998: Pellé R; Schramm V L; Parkin D W
Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence, expression, and molecular analysis.
The Journal of biological chemistry 1998;273(4):2118-26.
1998: Schramm V L
Enzymatic transition states and transition state analog design.
Annual review of biochemistry 1998;67():693-720.
1997: Schramm V L
Enzymatic N-riboside scission in RNA and RNA precursors.
Current opinion in chemical biology 1997;1(3):323-31.
1997: Scheuring J; Schramm V L
Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20.
Biochemistry 1997;36(27):8215-23.
1997: Scheuring J; Schramm V L
Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin.
Biochemistry 1997;36(15):4526-34.
1997: Parkin D W; Limberg G; Tyler P C; Furneaux R H; Chen X Y; Schramm V L
Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases.
Biochemistry 1997;36(12):3528-34.
1996: Link T; Chen X Y; Niu L H; Schramm V L
A hypothesis to explain the substrate reactivity of ribosomal and stem-loop RNA with ricin A-chain.
Toxicon : official journal of the International Society on Toxinology 1996;34(11-12):1317-24.
1996: Deng H; Chan A W; Bagdassarian C K; Estupiñán B; Ganem B; Callender R H; Schramm V L
Trypanosomal nucleoside hydrolase. Resonance Raman spectroscopy of a transition-state inhibitor complex.
Biochemistry 1996;35(19):6037-47.
1996: Degano M; Gopaul D N; Scapin G; Schramm V L; Sacchettini J C
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.
Biochemistry 1996;35(19):5971-81.
1996: Gopaul D N; Meyer S L; Degano M; Sacchettini J C; Schramm V L
Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.
Biochemistry 1996;35(19):5963-70.
1995: Parkin D W; Schramm V L
Binding modes for substrate and a proposed transition-state analogue of protozoan nucleoside hydrolase.
Biochemistry 1995;34(42):13961-6.
1995: Kline P C; Schramm V L
Pre-steady-state transition-state analysis of the hydrolytic reaction catalyzed by purine nucleoside phosphorylase.
Biochemistry 1995;34(4):1153-62.
1994: Estupiñán B; Schramm V L
Guanosine-inosine-preferring nucleoside N-glycohydrolase from Crithidia fasciculata.
The Journal of biological chemistry 1994;269(37):23068-73.
1994: Kline P C; Schramm V L
Electrostatic potential surfaces of the transition state for AMP deaminase and for (R)-coformycin, a transition state inhibitor.
The Journal of biological chemistry 1994;269(35):22385-90.
1994: Ehrlich J I; Schramm V L
Electrostatic potential surface analysis of the transition state for AMP nucleosidase and for formycin 5'-phosphate, a transition-state inhibitor.
Biochemistry 1994;33(30):8890-6.
1994: Schramm V L; Horenstein B A; Kline P C
Transition state analysis and inhibitor design for enzymatic reactions.
The Journal of biological chemistry 1994;269(28):18259-62.
1994: Boutellier M; Horenstein B A; Semenyaka A; Schramm V L; Ganem B
Amidrazone analogues of D-ribofuranose as transition-state inhibitors of nucleoside hydrolase.
Biochemistry 1994;33(13):3994-4000.
1993: Kline P C; Schramm V L
Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction.
Biochemistry 1993;32(48):13212-9.
1993: Merkler D J; Kline P C; Weiss P; Schramm V L
Transition-state analysis of AMP deaminase.
Biochemistry 1993;32(48):12993-3001.
1993: Horenstein B A; Schramm V L
Correlation of the molecular electrostatic potential surface of an enzymatic transition state with novel transition-state inhibitors.
Biochemistry 1993;32(38):9917-25.
1993: Horenstein B A; Schramm V L
Electronic nature of the transition state for nucleoside hydrolase. A blueprint for inhibitor design.
Biochemistry 1993;32(28):7089-97.
1993: Merkler D J; Schramm V L
Catalytic mechanism of yeast adenosine 5'-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects.
Biochemistry 1993;32(22):5792-9.
1993: Kvalnes-Krick K; Labdon J E; Ma X; Nieves E; Schramm V L
Mutagenic analysis of AMP nucleosidase from Escherichia coli. Deletion of a region similar to AMP deaminase and peptide characterization by mass spectrometry.
The Journal of biological chemistry 1993;268(12):8717-26.
1993: Sollitti P; Merkler D J; Estupiñán B; Schramm V L
Yeast AMP deaminase. Catalytic activity in Schizosaccharomyces pombe and chromosomal location in Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(6):4549-55.
1992: Kline P C; Schramm V L
Purine nucleoside phosphorylase. Inosine hydrolysis, tight binding of the hypoxanthine intermediate, and third-the-sites reactivity.
Biochemistry 1992;31(26):5964-73.
1991: Parkin D W; Horenstein B A; Abdulah D R; Estupiñán B; Schramm V L
Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism.
The Journal of biological chemistry 1991;266(31):20658-65.
1991: Horenstein B A; Parkin D W; Estupiñán B; Schramm V L
Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata.
Biochemistry 1991;30(44):10788-95.
1991: Chen C Y; Emig F A; Schramm V L; Ash D E
Inactivation of chicken mitochondrial phosphoenolpyruvate carboxykinase by o-phthalaldehyde.
The Journal of biological chemistry 1991;266(25):16645-52.
1991: Parkin D W; Mentch F; Banks G A; Horenstein B A; Schramm V L
Transition-state analysis of a Vmax mutant of AMP nucleosidase by the application of heavy-atom kinetic isotope effects.
Biochemistry 1991;30(18):4586-94.
1991: Chen C Y; Sato Y; Schramm V L
Isotope trapping and positional isotope exchange with rat and chicken liver phosphoenolpyruvate carboxykinases.
Biochemistry 1991;30(17):4143-51.
1990: Merkler D J; Brenowitz M; Schramm V L
The rate constant describing slow-onset inhibition of yeast AMP deaminase by coformycin analogues is independent of inhibitor structure.
Biochemistry 1990;29(36):8358-64.
1990: Ash D E; Emig F A; Chowdhury S A; Satoh Y; Schramm V L
Mammalian and avian liver phosphoenolpyruvate carboxykinase. Alternate substrates and inhibition by analogues of oxaloacetate.
The Journal of biological chemistry 1990;265(13):7377-84.
1990: Wente S R; Villalba M; Schramm V L; Rosen O M
Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2805-9.
1990: Merkler D J; Schramm V L
Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism.
The Journal of biological chemistry 1990;265(8):4420-6.
1989: Merkler D J; Wali A S; Taylor J; Schramm V L
AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme.
The Journal of biological chemistry 1989;264(35):21422-30.
1989: Meyer S L; Kvalnes-Krick K L; Schramm V L
Characterization of AMD, the AMP deaminase gene in yeast. Production of amd strain, cloning, nucleotide sequence, and properties of the protein.
Biochemistry 1989;28(22):8734-43.
1989: Leung H B; Kvalnes-Krick K L; Meyer S L; deRiel J K; Schramm V L
Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli.
Biochemistry 1989;28(22):8726-33.
1989: Giranda V L; Berman H M; Schramm V L
Crystallographic quaternary structural analysis of AMP nucleosidases from Escherichia coli and Azotobacter vinelandii.
The Journal of biological chemistry 1989;264(26):15674-80.
1988: Dolinger D L; Schramm V L; Shockman G D
Covalent modification of the beta-1,4-N-acetylmuramoylhydrolase of Streptococcus faecium with 5-mercaptouridine monophosphate.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6667-71.
1988: Giranda V L; Berman H M; Schramm V L
Crystal structure of formycin 5'-phosphate: an explanation for its tight binding to AMP nucleosidase.
Biochemistry 1988;27(15):5813-8.
1987: Merkler D J; Schramm V L
A preparative method for the enzymatic 5'-monophosphorylation of nucleosides.
Analytical biochemistry 1987;167(1):148-53.
1987: Markham G D; Parkin D W; Mentch F; Schramm V L
A kinetic isotope effect study and transition state analysis of the S-adenosylmethionine synthetase reaction.
The Journal of biological chemistry 1987;262(12):5609-15.
1987: Mentch F; Parkin D W; Schramm V L
Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator.
Biochemistry 1987;26(3):921-30.
1987: Parkin D W; Schramm V L
Catalytic and allosteric mechanism of AMP nucleosidase from primary, beta-secondary, and multiple heavy atom kinetic isotope effects.
Biochemistry 1987;26(3):913-20.
1986: Giranda V L; Berman H M; Schramm V L
Crystallization and preliminary X-ray study of AMP nucleosidase.
The Journal of biological chemistry 1986;261(32):15307-9.
1986: DeWolf W E; Emig F A; Schramm V L
AMP nucleosidase: kinetic mechanism and thermodynamics.
Biochemistry 1986;25(14):4132-40.
1985: Schramm V L; Baker D C
Spontaneous epimerization of (S)-deoxycoformycin and interaction of (R)-deoxycoformycin, (S)-deoxycoformycin, and 8-ketodeoxycoformycin with adenosine deaminase.
Biochemistry 1985;24(3):641-6.
1984: Barrett J F; Dolinger D L; Schramm V L; Shockman G D
The mechanism of soluble peptidoglycan hydrolysis by an autolytic muramidase. A processive exodisaccharidase.
The Journal of biological chemistry 1984;259(19):11818-27.
1984: Parkin D W; Leung H B; Schramm V L
Synthesis of nucleotides with specific radiolabels in ribose. Primary 14C and secondary 3H kinetic isotope effects on acid-catalyzed glycosidic bond hydrolysis of AMP, dAMP, and inosine.
The Journal of biological chemistry 1984;259(15):9411-7.
1984: Barrett J F; Schramm V L; Shockman G D
Hydrolysis of soluble, linear, un-cross-linked peptidoglycans by endogenous bacterial N-acetylmuramoylhydrolases.
Journal of bacteriology 1984;159(2):520-6.
1984: Parkin D W; Schramm V L
Effects of allosteric activation on the primary and secondary kinetic isotope effects for three AMP nucleosidases.
The Journal of biological chemistry 1984;259(15):9418-25.
1984: Leung H B; Schramm V L
The structural gene for AMP nucleosidase. Mapping, cloning, and overproduction of the enzyme.
The Journal of biological chemistry 1984;259(11):6972-8.
1984: Zlotnik H; Schramm V L; Buckley H R
Purification and partial characterization of a Nocardia brasiliensis extracellular protease.
Journal of bacteriology 1984;157(2):627-31.
1984: Schramm V L; McCluskey R; Emig F A; Litwack G
Kinetic studies and active site-binding properties of glutathione S-transferase using spin-labeled glutathione, a product analogue.
The Journal of biological chemistry 1984;259(2):714-22.
1983: Wilson D F; Erecinska M; Schramm V L
Evaluation of the relationship between the intra- and extramitochondrial [ATP]/[ADP] ratios using phosphoenolpyruvate carboxykinase.
The Journal of biological chemistry 1983;258(17):10464-73.
1981: Leung H B; Schramm V L
A mutant AMP nucleosidase. Purification, properties, and in vivo turnover of the protein.
The Journal of biological chemistry 1981;256(24):12823-9.
1981: Schramm V L; Fullin F A; Zimmerman M D
Kinetic studies of the interaction of substrates, Mn2+, and Mg2+ with the Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase.
The Journal of biological chemistry 1981;256(21):10803-8.
1981: Brinkworth R I; Hanson R W; Fullin F A; Schramm V L
Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase (GTP).
The Journal of biological chemistry 1981;256(21):10795-802.
1980: Leung H B; Schramm V L
Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme.
The Journal of biological chemistry 1980;255(22):10867-74.
1980: DeWolf W E; Markham G D; Schramm V L
Evidence of substantial separation of the catalytic and allosteric sites of AMP nucleosidase.
The Journal of biological chemistry 1980;255(17):8210-5.
1980: Schramm V L; Reed G H
Interaction of Mn2+ and MnATP2- with the allosteric sites of AMP nucleosidase.
The Journal of biological chemistry 1980;255(12):5796-801.
1979: DeWolf W E; Fullin F A; Schramm V L
The catalytic site of AMP nucleosidase. Substrate specificity and pH effects with AMP and formycin 5'-PO4.
The Journal of biological chemistry 1979;254(21):10868-75.
1979: DeWolf W E; Schramm V L
Synthesis of a new 8-spin-labeled analog of adenosine 5'-phosphate and its interaction with AMP nucleosidase.
The Journal of biological chemistry 1979;254(14):6215-7.
1978: Leung H B; Schramm V L
The role of adenosine monophosphate nucleosidase in the regulation of adenine nucleotide levels in Azotobacter vinelandii during aerobic-anaerobic transitions.
Archives of biochemistry and biophysics 1978;190(1):46-56.
1978: Jomain-Baum M; Schramm V L
Kinetic mechanism of phosphoenolpyruvate carboxykinase (GTP) from rat liver cytosol. Product inhibition, isotope exchange at equilibrium, and partial reactions.
The Journal of biological chemistry 1978;253(10):3648-59.
1978: Schramm V L; Fullin F A
Kinetics of adenosine monophosphate nucleosidase inactivation by phosphate and protection by substrate and allosteric activator.
The Journal of biological chemistry 1978;253(7):2161-7.
1978: Schramm V L; Leung H B
Adenosine monophosphate nucleosidase from Azotobacter vinelandii and Escherichia coli.
Methods in enzymology 1978;51():263-70.
1976: Schramm V L
Comparison of initial velocity and binding data for allosteric adenosine monophosphate nucleosidase.
The Journal of biological chemistry 1976;251(11):3417-24.
1976: Jomain-Baum M; Schramm V L; Hanson R W
Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP).
The Journal of biological chemistry 1976;251(1):37-44.
1975: Schramm V L; Lazorik F C
The pathway of adenylate catabolism in Azotobacter vinelandii. Evidence for adenosine monophosphate nucleosidase as the regulatory enzyme.
The Journal of biological chemistry 1975;250(5):1801-8.
1974: Plaut G W; Schramm V L; Aogaichi T
Action of magnesium ion on diphosphopyridine nucleotide-linked isocitrate dehydrogenase from bovine heart. Characterization of the forms of the substrate and the modifier of the reaction.
The Journal of biological chemistry 1974;249(6):1848-56.
1974: Schramm V L
Kinetic properties of allosteric adenosine monophosphate nucleosidase from Azotobacter vinelandii.
The Journal of biological chemistry 1974;249(6):1729-36.
1973: Schramm V L; Leung H
Regulation of adenosine monophosphate levels as a function of adenosine triphosphate and inorganic phosphate. A proposed metabolic role for adenosine monophosphate nucleosidase from Azotobacter vinelandii.
The Journal of biological chemistry 1973;248(23):8313-5.
1972: Schramm V L; Hochstein L I
Purification, crystallization, and subunit structure of allosteric adenosine 5'-monophosphate nucleosidase.
Biochemistry 1972;11(15):2777-83.
1971: Schramm V L; Hochstein L I
Stabilization of allosteric adenosine monophosphate nucleosidase by inorganic salts, substrate, and essential activator.
Biochemistry 1971;10(18):3411-7.
1971: Schramm V L; Morrison J F
Studies on the allosteric modification of nucleoside diphosphatase activity by magnesium nucleoside triphosphates and inosine diphosphate.
Biochemistry 1971;10(12):2272-7.
1970: Schramm V L; Morrison J F
Studies on an aged preparation of nucleoside diphosphatase. Kinetics and reaction mechanism.
Biochemistry 1970;9(3):671-7.
1969: Schramm V L; Morrison J F
Kinetic studies of the mechanism and allosteric activation of the reaction catalyzed by nucleoside diphosphatase.
Biochemistry 1969;8(9):3821-8.
1968: Schramm V L; Morrison J F
Purification, properties, and allosteric activation of nucleoside diphosphatase.
Biochemistry 1968;7(10):3642-52.

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