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Burkhart Schraven

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Börge Arndt; Thomas Kalinski; Dirk Reinhold; Albert Roessner; Burkhart Schraven; Anja Thielitz; Luca Simeoni
Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.
Anja Stirnweiss; Hannes Stockinger; Werner Zuschratter; Luca Simeoni; Steffi Gieseler; Matthias Gunzer; Thomas Harder; Roland Hartig; Jonathan A Lindquist; Camilla Merten; Wolfgang Paster; Lars Philipsen; Mateusz Poltorak; Yury Prokazov; Peter Reichardt; Burkhart Schraven
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.
Boerge Arndt; Bhavani S Kowtharapu; Jonathan A Lindquist; Lars Philipsen; Mateusz Poltorak; Peter Reichardt; Burkhart Schraven; Luca Simeoni
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.

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All Publications

2013: Börge Arndt; Thomas Kalinski; Dirk Reinhold; Albert Roessner; Burkhart Schraven; Anja Thielitz; Luca Simeoni
Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.
Journal of leukocyte biology 2013;93(3):353-62.
2013: Anja Stirnweiss; Hannes Stockinger; Werner Zuschratter; Luca Simeoni; Steffi Gieseler; Matthias Gunzer; Thomas Harder; Roland Hartig; Jonathan A Lindquist; Camilla Merten; Wolfgang Paster; Lars Philipsen; Mateusz Poltorak; Yury Prokazov; Peter Reichardt; Burkhart Schraven
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.
Science signaling 2013;6(263):ra13.
2013: Boerge Arndt; Bhavani S Kowtharapu; Jonathan A Lindquist; Lars Philipsen; Mateusz Poltorak; Peter Reichardt; Burkhart Schraven; Luca Simeoni
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.
Journal of immunological methods 2013;387(1-2):276-83.
2013: Michal Smida; Miloslav Suchanek; Monika C Brunner-Weinzierl; Clemens Cammann; Slavyana Gurbiel; Nadja Kerstin; Sabine Lindquist; Holger Lingel; Burkhart Schraven; Luca Simeoni; Jonathan A Lindquist
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.
Cell communication and signaling : CCS 2013;11(1):28.
2013: Kathrin Ballerstein; Tilo Beyer; Utz-Uwe Haus; Jonathan Axel Lindquist; Burkhart Schraven; Robert Weismantel
Discrete, qualitative models of interaction networks.
Frontiers in bioscience (Scholar edition) 2013;5():149-66.
2012: Mandy Pierau; Burkhart Schraven; Narasimhulu Simma; Theresa Lowinus; Alexander Marx; Shin-Young Na; Ursula H Bommhardt
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function.
European journal of immunology 2012;42(12):3381-93.
2012: Nicole Warnecke; James C Stone; Boerge Arndt; Bhavani S Kowtharapu; Mateusz Poltorak; Burkhart Schraven; Luca Simeoni
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
EMBO reports 2012;13(4):386-91.
2012: Stefanie Kliche; Bernhard Meineke; Markus Moser; Irene Patzak; Annegret Reinhold; Janine Degen; Reinhold Förster; Christian Freund; Friedemann Kiefer; Mauro Togni; Xiaoqian Wang; Tim Worbs; Burkhart Schraven
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.
Blood 2012;119(3):777-85.
2012: Mohammad Mobashir; Burkhart Schraven; Tilo Beyer
Simulated evolution of signal transduction networks.
PloS one 2012;7(12):e50905.
2012: Sebastian König; Michael Probst-Kepper; Tobias Reinl; Burkhart Schraven; Jochen Huehn; Andreas Jeron; Lothar Jänsch
First insight into the kinome of human regulatory T cells.
PloS one 2012;7(7):e40896.
2012: Mauro Togni; Swen Engelmann; Dirk Reinhold; Burkhart Schraven; Annegret Reinhold
The adapter protein ADAP is required for selected dendritic cell functions.
Cell communication and signaling : CCS 2012;10(1):14.
2011: Jeremy C Burns; Evann Corbo; Janine Degen; Mercy Gohil; Stefanie Kliche; Gary A Koretzky; Burkhart Schraven; Christine Anterasian; Martha S Jordan
The SLP-76 Src homology 2 domain is required for T cell development and activation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4459-66.
2011: Tilo Beyer; Mandy Busse; Slavyana Gurbiel; Utz-Uwe Haus; Kroum Hristov; Frank Pfeuffer; Burkhart Schraven; Michal Smida; Robert Weismantel; Kathrin Ballerstein; Jonathan A Lindquist
Integrating signals from the T-cell receptor and the interleukin-2 receptor.
PLoS computational biology 2011;7(8):e1002121.
2011: Anja Köhler; Katia De Filippo; Mike Hasenberg; Cindy van den Brandt; Emma Nye; Martin P Hosking; Thomas E Lane; Linda Männ; Richard M Ransohoff; Anja E Hauser; Oliver Winter; Burkhart Schraven; Hartmut Geiger; Nancy Hogg; Matthias Gunzer
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.
Blood 2011;117(16):4349-57.
2011: Börge Arndt; Thomas Kalinski; Tina Krieger; Dirk Reinhold; Albert Roessner; Burkhart Schraven; Anja Thielitz; Luca Simeoni
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.
PloS one 2011;6(9):e23761.
2011: Sabine Lindquist; Anita Posevitz-Fejfar; Burkhart Schraven; Brian Seed; Ramnik Xavier; Diana Karitkina; Kristina Langnaese; Jonathan A Lindquist
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
PloS one 2011;6(9):e23978.
2011: Mike Hasenberg; Anja Köhler; Susanne Bonifatius; Katrin Borucki; Monika Riek-Burchardt; Julia Achilles; Linda Männ; Kathleen Baumgart; Burkhart Schraven; Matthias Gunzer
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.
PloS one 2011;6(2):e17314.
2010: Cornelia Rieke; Thilo Kähne; Katrin Schweitzer; Burkhart Schraven; Jürgen Wienands; Michael Engelke; Michael Naumann
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells.
Cellular signalling 2010;22(3):395-403.
2010: Marc Sylvester; Stefanie Kliche; Sabine Lange; Sabine Geithner; Clementine Klemm; Andreas Schlosser; Arndt Grossmann; Ulrich Stelzl; Burkhart Schraven; Eberhard Krause; Christian Freund
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
PloS one 2010;5(7):e11708.
2010: Mahima Swamy; Gabrielle M Siegers; Gina J Fiala; Eszter Molnar; Elaine P Dopfer; Paul Fisch; Burkhart Schraven; Wolfgang Wa Schamel
Stoichiometry and intracellular fate of TRIM-containing TCR complexes.
Cell communication and signaling : CCS 2010;8():5.
2009: Christine Börner; Michal Smida; Volker Höllt; Burkhart Schraven; Jürgen Kraus
Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.
The Journal of biological chemistry 2009;284(51):35450-60.
2009: Mandy Pierau; Swen Engelmann; Dirk Reinhold; Thabo Lapp; Burkhart Schraven; Ursula H Bommhardt
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6124-34.
2009: Jessica Horn; Xiaoqian Wang; Peter Reichardt; Theresia E Stradal; Nicole Warnecke; Luca Simeoni; Matthias Gunzer; Deborah Yablonski; Burkhart Schraven; Stefanie Kliche
Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5756-67.
2009: Matthias Bleeke; Stefan Fest; Nicole Huebener; Christiane Landgraf; Burkhart Schraven; Gerhard Gaedicke; Rudolf Volkmer; Holger N Lode
Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma.
European journal of cancer (Oxford, England : 1990) 2009;45(16):2915-21.
2009: Carsten Linnemann; Frank A Schildberg; Anna Schurich; Linda Diehl; Silke I Hegenbarth; Elmar Endl; Svenja Lacher; Christa E Müller; Jürgen Frey; Luca Simeoni; Burkhart Schraven; Dirk Stabenow; Percy A Knolle
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling.
Immunology 2009;128(1 Suppl):e728-37.
2009: Christine Börner; Beate Warnick; Michal Smida; Roland Hartig; Jonathan A Lindquist; Burkhart Schraven; Volker Höllt; Jürgen Kraus
Mechanisms of opioid-mediated inhibition of human T cell receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):882-9.
2009: Annegret Reinhold; Sibylle Reimann; Dirk Reinhold; Burkhart Schraven; Mauro Togni
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo.
Journal of leukocyte biology 2009;86(1):61-71.
2008: Isabelle Bekeredjian-Ding; Anne Doster; Martin Schiller; Petra Heyder; Hanns-Martin Lorenz; Burkhart Schraven; Ursula Bommhardt; Klaus Heeg
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8267-77.
2008: Uwe Koelsch; Burkhart Schraven; Luca Simeoni
SIT and TRIM determine T cell fate in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5930-9.
2008: Laurence Veracini; Valérie Simon; Véronique Richard; Burkhart Schraven; Vaclav Horejsi; Serge Roche; Christine Benistant
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.
The Journal of cell biology 2008;182(3):603-14.
2008: Luca Simeoni; Jonathan A Lindquist; Michal Smida; Vanessa Witte; Boerge Arndt; Burkhart Schraven
Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins.
Immunological reviews 2008;224():215-28.
2008: Christine Börner; Jürgen Kraus; Andrea Bedini; Burkhart Schraven; Volker Höllt
T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional mu-opioid receptors.
Molecular pharmacology 2008;74(2):496-504.
2008: Xiaoqian Wang; Luca Simeoni; Jonathan A Lindquist; Julio Saez-Rodriguez; Andreas Ambach; Ernst Dieter Gilles; Stefanie Kliche; Burkhart Schraven
Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6703-12.
2008: Burkhart Schraven; Ulrich Kalinke
CD28 superagonists: what makes the difference in humans?
Immunity 2008;28(5):591-5.
2008: Sebastien Tauzin; Heidrun Ding; Karim Khatib; Ishtiaq Ahmad; Dimitri Burdevet; Gerhild van Echten-Deckert; Jonathan A Lindquist; Burkhart Schraven; Nasir-Ud- Din; Bettina Borisch; Daniel C Hoessli
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.
Blood 2008;111(4):2310-20.
2008: Vilmos Posevitz; Boerge Arndt; Tina Krieger; Nicole Warnecke; Burkhart Schraven; Luca Simeoni
Regulation of T cell homeostasis by the transmembrane adaptor protein SIT.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1634-42.
2008: Zoe Waibler; Linda Y Sender; Camilla Merten; Roland Hartig; Stefanie Kliche; Matthias Gunzer; Peter Reichardt; Ulrich Kalinke; Burkhart Schraven
Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
PloS one 2008;3(3):e1708.
2008: Anita Posevitz-Fejfár; Michal Smída; Stefanie Kliche; Roland Hartig; Burkhart Schraven; Jonathan A Lindquist
A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration.
European journal of immunology 2008;38(1):250-9.
2007: Claude Grégoire; Sarka Simova; Ying Wang; Amandine Sansoni; Sylvie Richelme; Anja Schmidt-Giese; Luca Simeoni; Pavla Angelisova; Dirk Reinhold; Burkhart Schraven; Vaclav Horejsi; Bernard Malissen; Marie Malissen
Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
European journal of immunology 2007;37(11):3259-69.
2007: Andrew Filby; Benedict Seddon; Joanna Kleczkowska; Robert Salmond; Peter Tomlinson; Michal Smida; Jonathan A Lindquist; Burkhart Schraven; Rose Zamoyska
Fyn regulates the duration of TCR engagement needed for commitment to effector function.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4635-44.
2007: Martha S Jordan; Jonathan S Maltzman; Stefanie Kliche; Jacob Shabason; Jennifer E Smith; Amrom Obstfeld; Burkhart Schraven; Gary A Koretzky
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction.
European journal of immunology 2007;37(10):2961-72.
2007: Julio Saez-Rodriguez; Luca Simeoni; Jonathan A Lindquist; Rebecca Hemenway; Ursula Bommhardt; Boerge Arndt; Utz-Uwe Haus; Robert Weismantel; Ernst Dieter Gilles; Steffen Klamt; Burkhart Schraven
A logical model provides insights into T cell receptor signaling.
PLoS computational biology 2007;3(8):e163.
2007: Gaël Ménasché; Stefanie Kliche; Natalie A. Bezman; Burkhart Schraven
Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.
Immunological reviews 2007;218():82-91.
2007: Burkhart Schraven; Michael Reth
Immunoreceptors and integrins.
Immunological reviews 2007;218():5-8.
2007: Michal Smida; Anita Posevitz-Fejfar; Vaclav Horejsi; Burkhart Schraven; Jonathan A Lindquist
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.
Blood 2007;110(2):596-615.
2007: Gaël Ménasché; Stefanie Kliche; Emily J H Chen; Theresia E B Stradal; Burkhart Schraven; Gary A Koretzky
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
Molecular and cellular biology 2007;27(11):4070-81.
2007: Vera Preller; Annegret Gerber; Sabine Wrenger; Mauro Togni; Didier Marguet; Janine Tadje; Uwe Lendeckel; Christoph Röcken; Jürgen Faust; Klaus Neubert; Burkhart Schraven; Roland Martin; Siegfried Ansorge; Stefan Brocke; Dirk Reinhold
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4632-40.
2007: Dominique Davidson; Burkhart Schraven; André Veillette
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.
Molecular and cellular biology 2007;27(5):1960-73.
2007: Ana Kasirer-Friede; Barry Moran; Jennifer Nagrampa-Orje; Ken Swanson; Zaverio M Ruggeri; Burkhart Schraven; Benjamin G Neel; Gary A Koretzky; Sanford J Shattil
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
Blood 2007;109(3):1018-25.
2007: Jonathan A Lindquist; Burkhart Schraven
Systems biology of T cell activation.
Ernst Schering Foundation symposium proceedings 2007;(3):43-61.
2006: Stefanie Kliche; Dennis Breitling; Mauro Togni; Rico Pusch; Katja Heuer; Xiaoqian Wang; Christian Freund; Ana Kasirer-Friede; Gael Menasche; Gary A Koretzky; Burkhart Schraven
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.
Molecular and cellular biology 2006;26(19):7130-44.
2006: Janine Reichenbach; Ralf Schubert; Rita Horvàth; Jens Petersen; Nancy Fütterer; Elisabeth Malle; Andreas Stumpf; Boris R Gebhardt; Ulrike Koehl; Burkhart Schraven; Stefan Zielen
Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency.
Pediatric research 2006;60(3):321-6.
2006: Katja Heuer; Marc Sylvester; Stefanie Kliche; Rico Pusch; Katharina Thiemke; Burkhart Schraven; Christian Freund
Lipid-binding hSH3 domains in immune cell adapter proteins.
Journal of molecular biology 2006;361(1):94-104.
2006: Uwe Kölsch; Börge Arndt; Dirk Reinhold; Jonathan A Lindquist; Nicole Jüling; Stefanie Kliche; Klaus Pfeffer; Eddy Bruyns; Burkhart Schraven; Luca Simeoni
Normal T-cell development and immune functions in TRIM-deficient mice.
Molecular and cellular biology 2006;26(9):3639-48.
2006: Vera Preller; Annegret Gerber; Mauro Togni; Sabine Wrenger; Burkhart Schraven; Christoph Röcken; Didier Marguet; Siegfried Ansorge; Stefan Brocke; Dirk Reinhold
CD26/DP IV in T cell activation and autoimmunity.
Advances in experimental medicine and biology 2006;575():187-93.
2005: Mauro Togni; Kenneth D Swanson; S Reimann; Stefanie Kliche; A C Pearce; Luca Simeoni; Dirk Reinhold; Jürgen Wienands; Benjamin G Neel; Burkhart Schraven; Annegret Gerber
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
Molecular and cellular biology 2005;25(18):8052-63.
2005: Luca Simeoni; Vilmos Posevitz; Uwe Kölsch; Ines Meinert; Eddy Bruyns; Klaus Pfeffer; Dirk Reinhold; Burkhart Schraven
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
Molecular and cellular biology 2005;25(17):7557-68.
2005: Ying Wang; Ondrej Horvath; Andrea Hamm-Baarke; Mireille Richelme; Claude Grégoire; Rodolphe Guinamard; Vaclav Horejsi; Pavla Angelisova; Jiri Spicka; Burkhart Schraven; Bernard Malissen; Marie Malissen
Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Molecular and cellular biology 2005;25(11):4455-65.
2005: Luca Simeoni; Michal Smida; Vilmos Posevitz; Burkhart Schraven; Jonathan A Lindquist
Right time, right place: the organization of membrane proximal signaling.
Seminars in immunology 2005;17(1):35-49.
2004: Stefanie Kliche; Jonathan A Lindquist; Burkhart Schraven
Transmembrane adapters: structure, biochemistry and biology.
Seminars in immunology 2004;16(6):367-77.
2004: Björn Stork; Michael Engelke; Jürgen Frey; Václav Horejsí; Andrea Hamm-Baarke; Burkhart Schraven; Tomohiro Kurosaki; Jürgen Wienands
Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Immunity 2004;21(5):681-91.
2004: Ralf Lobmann; Annelore Ittenson; S Schiweck; M Motzkau; Burkhart Schraven; Stephan Winckler; Hendrik Lehnert
Expression of cell surface antigens in diabetic patients and healthy controls after injury.
Diabetes, nutrition & metabolism 2004;17(4):244-6.
2004: Václav Horejsí; Weiguo Zhang; Burkhart Schraven
Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
Nature reviews. Immunology 2004;4(8):603-16.
2004: Mauro Togni; Jonathan A Lindquist; Annegret Gerber; Uwe Kölsch; Andrea Hamm-Baarke; Stefanie Kliche; Burkhart Schraven
The role of adaptor proteins in lymphocyte activation.
Molecular immunology 2004;41(6-7):615-30.
2004: Andrea Weren; Bernd Bonnekoh; Burkhart Schraven; Harald Gollnick; Andreas Ambach
A novel flow cytometric assay focusing on perforin release mechanisms of cytotoxic T lymphocytes.
Journal of immunological methods 2004;289(1-2):17-26.
2004: Luca Simeoni; Stefanie Kliche; Jonathan A Lindquist; Burkhart Schraven
Adaptors and linkers in T and B cells.
Current opinion in immunology 2004;16(3):304-13.
2003: Nadezda Brdicková; Tomás Brdicka; Pavla Angelisová; Ondrej Horváth; Jiri Spicka; Ivan Hilgert; Jan Paces; Luca Simeoni; Stefanie Kliche; Camilla Merten; Burkhart Schraven; Václav Horejsí
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
The Journal of experimental medicine 2003;198(10):1453-62.
2003: Barbara Marinari; Luca Simeoni; Burkhart Schraven; Enza Piccolella; Loretta Tuosto
The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.
European journal of immunology 2003;33(9):2609-18.
2003: Jonathan A Lindquist; Luca Simeoni; Burkhart Schraven
Transmembrane adapters: attractants for cytoplasmic effectors.
Immunological reviews 2003;191():165-82.
2002: Tomás Brdicka; Martin Imrich; Pavla Angelisová; Nadezda Brdicková; Ondrej Horváth; Jiri Spicka; Ivan Hilgert; Petra Lusková; Petr Dráber; Petr Novák; Niklas Engels; Jürgen Wienands; Luca Simeoni; Jan Osterreicher; Enrique Aguado; Marie Malissen; Burkhart Schraven; Václav Horejsí
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
The Journal of experimental medicine 2002;196(12):1617-26.
2002: Marylène Fortin; Ann-Muriel Steff; Jackie Felberg; Isabelle Ding; Burkhart Schraven; Pauline Johnson; Patrice Hugo
Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6084-9.
2002: Peter Wonerow; Achim Obergfell; Jonathan Wilde; Regis BOBE; Naoki Asazuma; Tomás Brdicka; Albrecht Leo; Burkhart Schraven; Václav Horejsí; Sanford J Shattil; Steve P Watson
Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets.
The Biochemical journal 2002;364(Pt 3):755-65.
2002: Albrecht Leo; Jürgen Wienands; Gottfried Baier; Vaclav Horejsi; Burkhart Schraven
Adapters in lymphocyte signaling.
The Journal of clinical investigation 2002;109(3):301-9.
2002: Corinna Klein; Eva-Maria Kramer; Anne-Marie Cardine; Burkhart Schraven; Roland Brandt; Jacqueline Trotter
Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):698-707.
2001: T Huynh; Andreas Würch; Eddy Bruyns; V Korinek; Burkhart Schraven; Klaus Eichmann
Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells.
Scandinavian journal of immunology 2001;54(1-2):146-54.
2001: Henning Kirchgessner; J Dietrich; J Scherer; Pia Isomäki; V Korinek; Ivan Hilgert; Eddy Bruyns; Albrecht Leo; A P Cope; Burkhart Schraven
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
The Journal of experimental medicine 2001;193(11):1269-84.
2001: K I Pfrepper; Anne Marie-Cardine; Luca Simeoni; Y Kuramitsu; Albrecht Leo; Jiri Spicka; Ivan Hilgert; J Scherer; Burkhart Schraven
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).
European journal of immunology 2001;31(6):1825-36.
2001: Albrecht Leo; Burkhart Schraven
Adapters in lymphocyte signalling.
Current opinion in immunology 2001;13(3):307-16.
2001: C Hübener; A Mincheva; Peter Lichter; Burkhart Schraven; Eddy Bruyns
Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT).
Immunogenetics 2001;53(4):337-41.
2000: Albrecht Leo; Burkhart Schraven
Networks in signal transduction: the role of adaptor proteins in platelet activation.
Platelets 2000;11(8):429-45.
2000: Naoki Asazuma; Jonathan Wilde; Oscar Berlanga; Mireille Leduc; Albrecht Leo; Edina Schweighoffer; Victor L J Tybulewicz; Cassian Bon; Stanley K-W Liu; C Jane McGlade; Burkhart Schraven; Steve P Watson
Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
The Journal of biological chemistry 2000;275(43):33427-34.
2000: Burkhart Schraven
CD2.
Journal of biological regulators and homeostatic agents 2000;14(3):223-5.
2000: Burkhart Schraven
CD148.
Journal of biological regulators and homeostatic agents 2000;14(3):220-2.
2000: Albrecht Leo; J Mytilineos; Maria Teresa Voso; R Weber-Nordt; P Liebisch; C Lensing; Burkhart Schraven
Passenger lymphocyte syndrome with severe hemolytic anemia due to an anti-Jk(a) after allogeneic PBPC transplantation.
Transfusion 2000;40(6):632-6.
2000: Tomás Brdicka; Dagmar Pavlistová; Albrecht Leo; Eddy Bruyns; V Korínek; Pavla Angelisová; J Scherer; A Shevchenko; Ivan Hilgert; J Cerný; Karel Drbal; Y Kuramitsu; B Kornacker; Václav Horejsí; Burkhart Schraven
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
The Journal of experimental medicine 2000;191(9):1591-604.
2000: C Hübener; A Mincheva; Peter Lichter; Burkhart Schraven; Eddy Bruyns
Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM).
Immunogenetics 2000;51(2):154-8.
1999: Isabelle Ding; Eddy Bruyns; P Li; D Magada; M Paskind; L Rodman; T Seshadri; D Alexander; Thomas Giese; Burkhart Schraven
Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP.
European journal of immunology 1999;29(12):3956-61.
1999: Anne Marie-Cardine; Burkhart Schraven
Coupling the TCR to downstream signalling pathways: the role of cytoplasmic and transmembrane adaptor proteins.
Cellular signalling 1999;11(10):705-12.
1999: Burkhart Schraven; Anne Marie-Cardine; C Hübener; Eddy Bruyns; Isabelle Ding
Integration of receptor-mediated signals in T cells by transmembrane adaptor proteins.
Immunology today 1999;20(10):431-4.
1999: M K Wild; W Strittmatter; S Matzku; Burkhart Schraven; Stefan C Meuer
Tumor therapy with bispecific antibody: the targeting and triggering steps can be separated employing a CD2-based strategy.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2064-72.
1999: Anne Marie-Cardine; Henning Kirchgessner; Eddy Bruyns; A Shevchenko; M Mann; Frank Autschbach; S Ratnofsky; Stefan C Meuer; Burkhart Schraven
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
The Journal of experimental medicine 1999;189(8):1181-94.
1999: Anne Marie-Cardine; Henning Kirchgessner; Burkhart Schraven
Molecular alterations of the Fyn-complex occur as late events of human T cell activation.
European journal of immunology 1999;29(4):1175-87.
1998: Anne Marie-Cardine; LR Hendricks-Taylor; NJ Boerth; H Zhao; Burkhart Schraven; Gary A Koretzky
Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.
The Journal of biological chemistry 1998;273(40):25789-95.
1998: Anne Marie-Cardine; A M Verhagen; C Eckerskorn; Burkhart Schraven
SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55.
FEBS letters 1998;435(1):55-60.
1998: Eddy Bruyns; Anne Marie-Cardine; Henning Kirchgessner; K Sagolla; A Shevchenko; M Mann; Frank Autschbach; Armand Bensussan; Stefan C Meuer; Burkhart Schraven
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.
The Journal of experimental medicine 1998;188(3):561-75.
1998: Eddy Bruyns; Henning Kirchgessner; Stefan C Meuer; Burkhart Schraven
Biochemical analysis of the CD45-p56(lck) complex in Jurkat T cells lacking expression of lymphocyte phosphatase-associated phosphoprotein.
International immunology 1998;10(2):185-94.
1998: Dorothea Stahl; H Kreft; H Hack; Burkhart Schraven; D Roelcke
Serum affinity chromatography for the detection of IgG alloantibodies in a patient with high-titer IgM cold agglutinins.
Vox sanguinis 1998;74(4):253-5.
1997: M K Wild; A M Verhagen; Stefan C Meuer; Burkhart Schraven
The receptor function of CD2 in human CD2 transgenic mice is based on highly conserved associations with signal transduction molecules.
Cellular immunology 1997;180(2):168-75.
1997: Anne Marie-Cardine; Eddy Bruyns; C Eckerskorn; Henning Kirchgessner; Stefan C Meuer; Burkhart Schraven
Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes.
The Journal of biological chemistry 1997;272(26):16077-80.
1997: Burkhart Schraven; Anne Marie-Cardine; Gary A Koretzky
Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling.
Immunology letters 1997;57(1-3):165-9.
1997: Dorothea Stahl; H Kreft; H Hack; Burkhart Schraven; D Roelcke
Identification of IgG alloantibodies in patients with high-titer IgM cold agglutinins by serum/plasma affinity chromatography.
Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine 1997;34():176-9.
1996: A M Verhagen; Burkhart Schraven; M Wild; Reinhard Wallich; Stefan C Meuer
Differential interaction of the CD2 extracellular and intracellular domains with the tyrosine phosphatase CD45 and the zeta chain of the TCR/CD3/zeta complex.
European journal of immunology 1996;26(12):2841-9.
1996: Eddy Bruyns; A Mincheva; R M Bruyns; Henning Kirchgessner; S Weitz; Peter Lichter; Stefan C Meuer; Burkhart Schraven
Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.
Genomics 1996;38(1):79-83.
1995: Eddy Bruyns; L R Hendricks-Taylor; Stefan C Meuer; Gary A Koretzky; Burkhart Schraven
Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45.
The Journal of biological chemistry 1995;270(52):31372-6.
1995: Anne Marie-Cardine; Henning Kirchgessner; C Eckerskorn; Stefan C Meuer; Burkhart Schraven
Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase.
European journal of immunology 1995;25(12):3290-7.
1995: Burkhart Schraven; Marcus E Peter
APO-1(CD95)-mediated apoptosis in Jurkat cells does not involve src kinases or CD45.
FEBS letters 1995;368(3):491-4.
1995: Stefan C Meuer; Y Samstag; Burkhart Schraven
Accessory signals for growth and differentiation of human T lymphocytes.
Cancer surveys 1995;22():63-73.
1994: Burkhart Schraven; D Schoenhaut; Eddy Bruyns; Gary A Koretzky; C Eckerskorn; Reinhard Wallich; Henning Kirchgessner; P Sakorafas; B Labkovsky; S Ratnofsky
LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes.
The Journal of biological chemistry 1994;269(46):29102-11.
1994: Burkhart Schraven; S Ratnofsky; Y Gaumont; H Lindegger; Henning Kirchgessner; Eddy Bruyns; U Moebius; Stefan C Meuer
Identification of a novel dimeric phosphoprotein (PP29/30) associated with signaling receptors in human T lymphocytes and natural killer cells.
The Journal of experimental medicine 1994;180(3):897-906.
1994: Stefan C Meuer; Burkhart Schraven; Y Samstag
An 'alternative' pathway of T cell activation.
International archives of allergy and immunology 1994;104(3):216-21.
1994: Frank Rösl; M Lengert; J Albrecht; K Kleine; R Zawatzky; Burkhart Schraven; Harald zur Hausen
Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids.
Journal of virology 1994;68(4):2142-50.
1994: S E Ross; Burkhart Schraven; Frederick D Goldman; J Crabtree; Gary A Koretzky
The association between CD45 and lck does not require CD4 or CD8 and is independent of T cell receptor stimulation.
Biochemical and biophysical research communications 1994;198(1):88-96.
1993: Stefan C Meuer; Burkhart Schraven; Y Samstag
Molecular mechanisms mediating lymphocyte recirculation, inflammation, and metastasis formation.
The American review of respiratory disease 1993;148(6 Pt 2):S65-9.
1993: U Westenfelder; Burkhart Schraven; Daniela N Männel
Characterization of monocyte-activating tumour cell membrane structures.
Scandinavian journal of immunology 1993;38(4):388-94.
1993: S Wesselborg; U Prüfer; M Wild; Burkhart Schraven; Stefan C Meuer; Dieter Kabelitz
Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes.
European journal of immunology 1993;23(10):2707-10.
1993: Burkhart Schraven; M Wild; Henning Kirchgessner; B Siebert; Reinhard Wallich; S Henning; Y Samstag; Stefan C Meuer
Alterations of CD2 association with T cell receptor signaling molecules in "CD2 unresponsive" human T lymphocytes.
European journal of immunology 1993;23(1):119-23.
1992: Burkhart Schraven; A Schirren; Henning Kirchgessner; B Siebert; Stefan C Meuer
Four CD45/P56lck-associated phosphorproteins (pp29-pp32) undergo alterations in human T cell activation.
European journal of immunology 1992;22(7):1857-63.
1991: M Roux; Burkhart Schraven; A Roux; H Gamm; R Mertelsmann; Stefan C Meuer
Natural inhibitors of T-cell activation in Hodgkin's disease.
Blood 1991;78(9):2365-71.
1991: Burkhart Schraven; Henning Kirchgessner; B Gaber; Y Samstag; Stefan C Meuer
A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate.
European journal of immunology 1991;21(10):2469-77.
1991: B Endler-Jobst; Burkhart Schraven; B Hutmacher; Stefan C Meuer
Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1736-42.
1990: Burkhart Schraven; Y Samstag; Peter Altevogt; Stefan C Meuer
Association of CD2 and CD45 on human T lymphocytes.
Nature 1990;345(6270):71-4.
1990: Peter Altevogt; J Schreck; Burkhart Schraven; Stefan C Meuer; Volker Schirrmacher; A Mitsch
Association of CD2 and T200 (CD45) in mouse T lymphocytes.
International immunology 1990;2(4):353-60.
1989: Burkhart Schraven; M Roux; B Hutmacher; Stefan C Meuer
Triggering of the alternative pathway of human T cell activation involves members of the T 200 family of glycoproteins.
European journal of immunology 1989;19(2):397-403.
1989: Stefan C Meuer; M M Roux; Burkhart Schraven
The alternative pathway of T cell activation: biology, pathophysiology, and perspectives for immunopharmacology.
Clinical immunology and immunopathology 1989;50(1 Pt 2):S133-9.
1988: Stefan C Meuer; Burkhart Schraven; U Möbius
T cell activation by monoclonal antibodies: an approach to study principles of immunoregulation.
Transplantation proceedings 1988;20(2):269-72.