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Gideon Schreiber

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TOP 3
Yael Phillip; Gideon Schreiber
Formation of protein complexes in crowded environments--from in vitro to in vivo.
Amir Apelbaum; Daniel Harari; Shira Warszawski; Ganit Yarden; Gideon Schreiber
Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands.
Ruth Khait; Gideon Schreiber
FRETex: a FRET-based, high-throughput technique to analyze protein-protein interactions.

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All Publications

2013: Yael Phillip; Gideon Schreiber
Formation of protein complexes in crowded environments--from in vitro to in vivo.
FEBS letters 2013;587(8):1046-52.
2013: Amir Apelbaum; Daniel Harari; Shira Warszawski; Ganit Yarden; Gideon Schreiber
Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands.
Molecular and cellular biology 2013;33(4):800-14.
2012: Ruth Khait; Gideon Schreiber
FRETex: a FRET-based, high-throughput technique to analyze protein-protein interactions.
Protein engineering, design & selection : PEDS 2012;25(11):681-7.
2012: Yael Phillip; SANBO QIN; Michal Harel; Ruth Khait; Huan-Xiang Zhou; Gideon Schreiber
Contrasting factors on the kinetic path to protein complex formation diminish the effects of crowding agents.
Biophysical journal 2012;103(5):1011-9.
2012: Yael Phillip; Vladimir Kiss; Gideon Schreiber
Protein-binding dynamics imaged in a living cell.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1461-6.
2011: Doron Levin; Daniel Harari; Gideon Schreiber
Stochastic receptor expression determines cell fate upon interferon treatment.
Molecular and cellular biology 2011;31(16):3252-66.
2011: Gideon Schreiber; Amy E Keating
Protein binding specificity versus promiscuity.
Current opinion in structural biology 2011;21(1):50-61.
2011: Ori Cohavi; Dana Reichmann; Renne Abramovich; Alexander B Tesler; Giuliano Bellapadrona; Daria B Kokh; Rebecca C Wade; Alexander Vaskevich; Israel Rubinstein; Gideon Schreiber
A quantitative, real-time assessment of binding of peptides and proteins to gold surfaces.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(4):1327-36.
2010: Gideon Schreiber; Mark R Walter
Cytokine-receptor interactions as drug targets.
Current opinion in chemical biology 2010;14(4):511-9.
2010: Ori Cohavi; Stefano Corni; Francesca De Rienzo; Rosa Di Felice; Kay-Eberhard Gottschalk; Martin Hoefling; Daria Kokh; Elisa Molinari; Gideon Schreiber; Alexander Vaskevich; Rebecca C Wade
Protein-surface interactions: challenging experiments and computations.
Journal of molecular recognition : JMR 2010;23(3):259-62.
2010: Vladimir Potapov; Mati Cohen; Yuval Inbar; Gideon Schreiber
Protein structure modelling and evaluation based on a 4-distance description of side-chain interactions.
BMC bioinformatics 2010;11():374.
2009: Ofer Rahat; Uri Alon; Yaakov Levy; Gideon Schreiber
Understanding hydrogen-bond patterns in proteins using network motifs.
Bioinformatics (Oxford, England) 2009;25(22):2921-8.
2009: Vladimir Potapov; Mati Cohen; Gideon Schreiber
Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details.
Protein engineering, design & selection : PEDS 2009;22(9):553-60.
2009: Yael Phillip; Eilon Sherman; Gilad Haran; Gideon Schreiber
Common crowding agents have only a small effect on protein-protein interactions.
Biophysical journal 2009;97(3):875-85.
2009: Mati Cohen; Vladimir Potapov; Gideon Schreiber
Four distances between pairs of amino acids provide a precise description of their interaction.
PLoS computational biology 2009;5(8):e1000470.
2009: Ori Cohavi; Dror Tobi; Gideon Schreiber
Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data.
Journal of molecular biology 2009;390(3):503-15.
2009: Michal Harel; Alexander Spaar; Gideon Schreiber
Fruitful and futile encounters along the association reaction between proteins.
Biophysical journal 2009;96(10):4237-48.
2009: Gideon Schreiber; Gilad Haran; H-X Zhou
Fundamental aspects of protein-protein association kinetics.
Chemical reviews 2009;109(3):839-60.
2008: Vladimir Potapov; Dana Reichmann; R Abramovich; D Filchtinski; N Zohar; D Ben Halevy; Marvin Edelman; Vladimir Sobolev; Gideon Schreiber
Computational redesign of a protein-protein interface for high affinity and binding specificity using modular architecture and naturally occurring template fragments.
Journal of molecular biology 2008;384(1):109-19.
2008: Eyal Kalie; Diego A Jaitin; Yulia Podoplelova; Jacob Piehler; Gideon Schreiber
The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.
The Journal of biological chemistry 2008;283(47):32925-36.
2008: Mati Cohen; Dana Reichmann; Hani Neuvirth; Gideon Schreiber
Similar chemistry, but different bond preferences in inter versus intra-protein interactions.
Proteins 2008;72(2):741-53.
2008: Ofer Rahat; Assif Yitzhaky; Gideon Schreiber
Cluster conservation as a novel tool for studying protein-protein interactions evolution.
Proteins 2008;71(2):621-30.
2008: Dana Reichmann; Yael Phillip; Asaf Carmi; Gideon Schreiber
On the contribution of water-mediated interactions to protein-complex stability.
Biochemistry 2008;47(3):1051-60.
2007: Yoav Adam; Naama Tayer; Dvir Rotem; Gideon Schreiber; Shimon Schuldiner
The fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporter.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):17989-94.
2007: Michal Harel; Mati Cohen; Gideon Schreiber
On the dynamic nature of the transition state for protein-protein association as determined by double-mutant cycle analysis and simulation.
Journal of molecular biology 2007;371(1):180-96.
2007: Diego A Jaitin; Gideon Schreiber
Upregulation of a small subset of genes drives type I interferon-induced antiviral memory.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(8):653-64.
2007: Hani Neuvirth; Uri Heinemann; David Birnbaum; Naftali Tishby; Gideon Schreiber
ProMateus--an open research approach to protein-binding sites analysis.
Nucleic acids research 2007;35(Web Server issue):W543-8.
2007: Eran Hodis; Gideon Schreiber; Kristian Rother; Joel Sussman
eMovie: a storyboard-based tool for making molecular movies.
Trends in biochemical sciences 2007;32(5):199-204.
2007: Eyal Kalie; Diego A Jaitin; Renne Abramovich; Gideon Schreiber
An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities.
The Journal of biological chemistry 2007;282(15):11602-11.
2007: Noga Kozer; Yosef Yehuda Kuttner; Gilad Haran; Gideon Schreiber
Protein-protein association in polymer solutions: from dilute to semidilute to concentrated.
Biophysical journal 2007;92(6):2139-49.
2007: Dana Reichmann; Ofer Rahat; Mati Cohen; Hani Neuvirth; Gideon Schreiber
The molecular architecture of protein-protein binding sites.
Current opinion in structural biology 2007;17(1):67-76.
2007: Dana Reichmann; Mati Cohen; R Abramovich; Orly Dym; D Lim; N C J Strynadka; Gideon Schreiber
Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.
Journal of molecular biology 2007;365(3):663-79.
2007: Barak Raveh; Ofer Rahat; Ronen Basri; Gideon Schreiber
Rediscovering secondary structures as network motifs--an unsupervised learning approach.
Bioinformatics (Oxford, England) 2007;23(2):e163-9.
2006: Michal Slutzki; Diego A Jaitin; Tuval Ben Yehezkel; Gideon Schreiber
Variations in the unstructured C-terminal tail of interferons contribute to differential receptor binding and biological activity.
Journal of molecular biology 2006;360(5):1019-30.
2006: Diego A Jaitin; Laila Roisman; Eva Jaks; Martynas Gavutis; Jacob Piehler; José Van der Heyden; Gilles Uze; Gideon Schreiber
Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta.
Molecular and cellular biology 2006;26(5):1888-97.
2006: Gideon Schreiber; Yosef Shaul; Kay-Eberhard Gottschalk
Electrostatic design of protein-protein association rates.
Methods in molecular biology (Clifton, N.J.) 2006;340():235-49.
2005: Yosef Yehuda Kuttner; Noga Kozer; Eugenia Segal; Gideon Schreiber; Gilad Haran
Separating the contribution of translational and rotational diffusion to protein association.
Journal of the American Chemical Society 2005;127(43):15138-44.
2005: Laila Roisman; Diego A Jaitin; Darren P Baker; Gideon Schreiber
Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site.
Journal of molecular biology 2005;353(2):271-81.
2005: Shira Albeck; Yigal Burstein; Orly Dym; Yossi Jacobovitch; Nurit Levi; Ran Meged; Yigal Michael; Yoav Peleg; Jaime Prilusky; Gideon Schreiber; Israel Silman; Tamar Unger; Joel Sussman
Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1364-72.
2005: Yosef Shaul; Gideon Schreiber
Exploring the charge space of protein-protein association: a proteomic study.
Proteins 2005;60(3):341-52.
2005: Dana Reichmann; Ofer Rahat; Shira Albeck; Ran Meged; Orly Dym; Gideon Schreiber
The modular architecture of protein-protein binding interfaces.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):57-62.
2004: Tal Peleg-Shulman; Haim Tsubery; Marina Mironchik; Mati Fridkin; Gideon Schreiber; Yoram Shechter
Reversible PEGylation: a novel technology to release native interferon alpha2 over a prolonged time period.
Journal of medicinal chemistry 2004;47(20):4897-904.
2004: Tal Peleg-Shulman; Laila Roisman; Gordin Zupkovitz; Gideon Schreiber
Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.
The Journal of biological chemistry 2004;279(17):18046-53.
2004: Hani Neuvirth; Ran Raz; Gideon Schreiber
ProMate: a structure based prediction program to identify the location of protein-protein binding sites.
Journal of molecular biology 2004;338(1):181-99.
2004: Noga Kozer; Gideon Schreiber
Effect of crowding on protein-protein association rates: fundamental differences between low and high mass crowding agents.
Journal of molecular biology 2004;336(3):763-74.
2004: Kay-Eberhard Gottschalk; Hani Neuvirth; Gideon Schreiber
A novel method for scoring of docked protein complexes using predicted protein-protein binding sites.
Protein engineering, design & selection : PEDS 2004;17(2):183-9.
2003: Jordan H Chill; Sabine R Quadt; Rina Levy; Gideon Schreiber; Jacob Anglister
The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding.
Structure (London, England : 1993) 2003;11(7):791-802.
2002: Jordan H Chill; Rachel Nivasch; Rina Levy; Shira Albeck; Gideon Schreiber; Jacob Anglister
The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening.
Biochemistry 2002;41(11):3575-85.
2002: Gideon Schreiber
Kinetic studies of protein-protein interactions.
Current opinion in structural biology 2002;12(1):41-7.
2001: T Selzer; Gideon Schreiber
New insights into the mechanism of protein-protein association.
Proteins 2001;45(3):190-8.
2001: Laila Roisman; Jacob Piehler; J Y Trosset; H A Scheraga; Gideon Schreiber
Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13231-6.
2001: Jacob Piehler; Gideon Schreiber
Fast transient cytokine-receptor interactions monitored in real time by reflectometric interference spectroscopy.
Analytical biochemistry 2001;289(2):173-86.
2001: Yoram Shechter; L Preciado-Patt; Gideon Schreiber; Mati Fridkin
Prolonging the half-life of human interferon-alpha 2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1212-7.
2001: Gideon Schreiber
Methods for studying the interaction of barnase with its inhibitor barstar.
Methods in molecular biology (Clifton, N.J.) 2001;160():213-26.
2000: Jacob Piehler; Laila Roisman; Gideon Schreiber
New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface.
The Journal of biological chemistry 2000;275(51):40425-33.
2000: T Selzer; Shira Albeck; Gideon Schreiber
Rational design of faster associating and tighter binding protein complexes.
Nature structural biology 2000;7(7):537-41.
2000: Shira Albeck; R Unger; Gideon Schreiber
Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges.
Journal of molecular biology 2000;298(3):503-20.
1999: Jacob Piehler; Gideon Schreiber
Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2.
Journal of molecular biology 1999;294(1):223-37.
1999: Jacob Piehler; Gideon Schreiber
Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.
Journal of molecular biology 1999;289(1):57-67.
1999: T Selzer; Gideon Schreiber
Predicting the rate enhancement of protein complex formation from the electrostatic energy of interaction.
Journal of molecular biology 1999;287(2):409-19.
1999: Shira Albeck; Gideon Schreiber
Biophysical characterization of the interaction of the beta-lactamase TEM-1 with its protein inhibitor BLIP.
Biochemistry 1999;38(1):11-21.
1997: Gideon Schreiber; C Frisch; Alan Fersht
The role of Glu73 of barnase in catalysis and the binding of barstar.
Journal of molecular biology 1997;270(1):111-22.