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William Blakemore

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TOP 3
K A Irvine; William F Blakemore
Remyelination protects axons from demyelination-associated axon degeneration.
William F Blakemore; K-A Irvine
Endogenous or exogenous oligodendrocytes for remyelination.
D P J Hunt; K A Irvine; Daniel J Webber; D A S Compston; William F Blakemore; Siddharthan Chandran
Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord.

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All Publications

2008: K A Irvine; William F Blakemore
Remyelination protects axons from demyelination-associated axon degeneration.
Brain : a journal of neurology 2008;131(Pt 6):1464-77.
2008: William F Blakemore; K-A Irvine
Endogenous or exogenous oligodendrocytes for remyelination.
Journal of the neurological sciences 2008;265(1-2):43-6.
2008: D P J Hunt; K A Irvine; Daniel J Webber; D A S Compston; William F Blakemore; Siddharthan Chandran
Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord.
Cell transplantation 2008;17(7):865-73.
2008: William F Blakemore; R J M Franklin
Remyelination in experimental models of toxin-induced demyelination.
Current topics in microbiology and immunology 2008;318():193-212.
2007: Ashwin Woodhoo; V Sahni; Jennifer M Gilson; Anna Setzu; Robin J M Franklin; William F Blakemore; Rhona Mirsky; Kristjan R Jessen
Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System.
Brain : a journal of neurology 2007;130(Pt 8):2175-85.
2007: Alexis Joannides; Daniel J Webber; Olivier Raineteau; Claire Kelly; Karen-Amanda Irvine; Colin Watts; Anne E Rosser; Paul J Kemp; William F Blakemore; Alastair Compston; Maeve A Caldwell; Nicholas D Allen; Siddharthan Chandran
Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells.
Brain : a journal of neurology 2007;130(Pt 5):1263-75.
2007: Karen-Amanda Irvine; William F Blakemore
A different regional response by mouse oligodendrocyte progenitor cells (OPCs) to high-dose X-irradiation has consequences for repopulating OPC-depleted normal tissue.
The European journal of neuroscience 2007;25(2):417-24.
2006: V Tepavcević; William F Blakemore
Haplotype matching is not an essential requirement to achieve remyelination of demyelinating CNS lesions.
Glia 2006;54(8):880-90.
2006: K-A Irvine; William F Blakemore
Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice.
Journal of neuroimmunology 2006;175(1-2):69-76.
2006: Divya M Chari; Chao Zhao; Mark R Kotter; William F Blakemore; Robin J M Franklin
Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system.
Journal of neuroscience research 2006;83(4):594-605.
2006: Divya M Chari; Jennifer M Gilson; Robin J M Franklin; William F Blakemore
Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS.
Experimental neurology 2006;198(1):145-53.
2005: V Tepavcević; William F Blakemore
Glial grafting for demyelinating disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1461):1775-95.
2005: AK Foote; William F Blakemore
Repopulation of oligodendrocyte progenitor cell-depleted tissue in a model of chronic demyelination.
Neuropathology and applied neurobiology 2005;31(4):374-83.
2005: AK Foote; William F Blakemore
Repopulation of oligodendrocyte progenitor cell depleted tissue in a model of chronic demyelination.
Neuropathology and applied neurobiology 2005;31(2):105-14.
2005: AK Foote; William F Blakemore
Inflammation stimulates remyelination in areas of chronic demyelination.
Brain : a journal of neurology 2005;128(Pt 3):528-39.
2005: William F Blakemore
The case for a central nervous system (CNS) origin for the Schwann cells that remyelinate CNS axons following concurrent loss of oligodendrocytes and astrocytes.
Neuropathology and applied neurobiology 2005;31(1):1-10.
2004: A John Crang; Jennifer M Gilson; Wen-Wu Li; William F Blakemore
The remyelinating potential and in vitro differentiation of MOG-expressing oligodendrocyte precursors isolated from the adult rat CNS.
The European journal of neuroscience 2004;20(6):1445-60.
2004: Siddharthan Chandran; Alastair Compston; Eric Jauniaux; Jennifer M Gilson; William F Blakemore; Clive Svendsen
Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors.
Glia 2004;47(4):314-24.
2004: G Li; William F Blakemore
The number of cells expressing the myelin-supporting oligodendrocyte marker PLP-exon 3b remains unchanged in Wallerian degeneration.
Journal of neurotrauma 2004;21(8):1044-9.
2003: William F Blakemore; Jennifer M Gilson; A John Crang
The presence of astrocytes in areas of demyelination influences remyelination following transplantation of oligodendrocyte progenitors.
Experimental neurology 2003;184(2):955-63.
2003: Divya M Chari; W L Huang; William F Blakemore
Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue.
Journal of neuroscience research 2003;73(6):787-93.
2003: Divya M Chari; A John Crang; William F Blakemore
Decline in rate of colonization of oligodendrocyte progenitor cell (OPC)-depleted tissue by adult OPCs with age.
Journal of neuropathology and experimental neurology 2003;62(9):908-16.
2002: Guilin Li; A John Crang; Jon L Rundle; William F Blakemore
Oligodendrocyte progenitor cells in the adult rat CNS express myelin oligodendrocyte glycoprotein (MOG).
Brain pathology (Zurich, Switzerland) 2002;12(4):463-71.
2002: Divya M Chari; William F Blakemore
New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation.
Multiple sclerosis (Houndmills, Basingstoke, England) 2002;8(4):271-7.
2002: Jennifer M Gilson; William F Blakemore
Schwann cell remyelination is not replaced by oligodendrocyte remyelination following ethidium bromide induced demyelination.
Neuroreport 2002;13(9):1205-8.
2002: William F Blakemore; Divya M Chari; Jennifer M Gilson; A John Crang
Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS.
Glia 2002;38(2):155-68.
2002: Divya M Chari; William F Blakemore
Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells.
Glia 2002;37(4):307-13.
2001: GL Hinks; Divya M Chari; MT O'Leary; Chao Zhao; HS Keirstead; William F Blakemore; Robin J M Franklin
Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS.
Neuropathology and applied neurobiology 2001;27(1):59-67.
2001: C M H Brierley; A John Crang; Y Iwashita; Jennifer M Gilson; Neil Scolding; D A S Compston; William F Blakemore
Remyelination of demyelinated CNS axons by transplanted human schwann cells: the deleterious effect of contaminating fibroblasts.
Cell transplantation 2001;10(3):305-15.
2000: Y Iwashita; William F Blakemore
Areas of demyelination do not attract significant numbers of schwann cells transplanted into normal white matter.
Glia 2000;31(3):232-40.
2000: Y Iwashita; James W Fawcett; A John Crang; Robin J M Franklin; William F Blakemore
Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival.
Experimental neurology 2000;164(2):292-302.
2000: William F Blakemore; Jennifer M Gilson; A John Crang
Transplanted glial cells migrate over a greater distance and remyelinate demyelinated lesions more rapidly than endogenous remyelinating cells.
Journal of neuroscience research 2000;61(3):288-94.
2000: Peter M Smith; William F Blakemore
Porcine neural progenitors require commitment to the oligodendrocyte lineage prior to transplantation in order to achieve significant remyelination of demyelinated lesions in the adult CNS.
The European journal of neuroscience 2000;12(7):2414-24.
2000: Simon A Shields; William F Blakemore; Robin J M Franklin
Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated adult rat brain.
Journal of neuroscience research 2000;60(5):571-8.
2000: Y Iwashita; A John Crang; William F Blakemore
Redistribution of bisbenzimide Hoechst 33342 from transplanted cells to host cells.
Neuroreport 2000;11(5):1013-6.
2000: William F Blakemore; R J Franklin
Transplantation options for therapeutic central nervous system remyelination.
Cell transplantation 2000;9(2):289-94.
2000: William F Blakemore; Peter M Smith; Robin J M Franklin
Remyelinating the demyelinated CNS.
Novartis Foundation symposium 2000;231():289-98; discussion 298-306.
1999: Simon A Shields; Jennifer M Gilson; William F Blakemore; Robin J M Franklin
Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination.
Glia 1999;28(1):77-83.
1999: HS Keirstead; T Ben-Hur; Bernard Rogister; MT O'Leary; Monique Dubois-Dalcq; William F Blakemore
Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(17):7529-36.
1999: Nick D Jeffery; William F Blakemore
Spinal cord injury in small animals 2. Current and future options for therapy.
The Veterinary record 1999;145(7):183-90.
1999: William F Blakemore; HS Keirstead
The origin of remyelinating cells in the central nervous system.
Journal of neuroimmunology 1999;98(1):69-76.
1999: Nick D Jeffery; A John Crang; MT O'Leary; Sarah J Hodge; William F Blakemore
Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord.
The European journal of neuroscience 1999;11(5):1508-14.
1999: Nick D Jeffery; William F Blakemore
Spinal cord injury in small animals. 1. Mechanisms of spontaneous recovery.
The Veterinary record 1999;144(15):407-13.
1999: HS Keirstead; William F Blakemore
The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination.
Advances in experimental medicine and biology 1999;468():183-97.
1998: J S McKay; William F Blakemore; Robin J M Franklin
Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes.
Neuropathology and applied neurobiology 1998;24(6):498-506.
1998: AC Palmer; William F Blakemore; Robin J M Franklin; L M Frost; R E Gough; J C M Lewis; D F Macdougall; MT O'Leary; L R Stocker
Paralysis in hedgehogs (Erinaceus europaeus) associated with demyelination.
The Veterinary record 1998;143(20):550-2.
1998: Robin J M Franklin; William F Blakemore
Transplanting myelin-forming cells into the central nervous system: principles and practice.
Methods (San Diego, Calif.) 1998;16(3):311-9.
1998: MT O'Leary; Raymond Bujdoso; William F Blakemore
Rejection of wild-type and genetically engineered major histocompatibility complex-deficient glial cell xenografts in the central nervous system results in bystander demyelination and Wallerian degeneration.
Neuroscience 1998;85(1):269-80.
1998: HS Keirstead; H C Hughes; William F Blakemore
A quantifiable model of axonal regeneration in the demyelinated adult rat spinal cord.
Experimental neurology 1998;151(2):303-13.
1998: HS Keirstead; Joel M Levine; William F Blakemore
Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord.
Glia 1998;22(2):161-70.
1998: A John Crang; Jennifer M Gilson; William F Blakemore
The demonstration by transplantation of the very restricted remyelinating potential of post-mitotic oligodendrocytes.
Journal of neurocytology 1998;27(7):541-53.
1997: HS Keirstead; William F Blakemore
Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord.
Journal of neuropathology and experimental neurology 1997;56(11):1191-201.
1997: Robin J M Franklin; Jennifer M Gilson; William F Blakemore
Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system.
Journal of neuroscience research 1997;50(2):337-44.
1997: A John Crang; William F Blakemore
Attempts to produce astrocyte cultures devoid of oligodendrocyte generating potential by the use of antimitotic treatment reveal the presence of quiescent oligodendrocyte precursors.
Journal of neuroscience research 1997;49(1):64-71.
1997: MT O'Leary; William F Blakemore
Oligodendrocyte precursors survive poorly and do not migrate following transplantation into the normal adult central nervous system.
Journal of neuroscience research 1997;48(2):159-67.
1997: Robin J M Franklin; William F Blakemore
To what extent is oligodendrocyte progenitor migration a limiting factor in the remyelination of multiple sclerosis lesions?
Multiple sclerosis (Houndmills, Basingstoke, England) 1997;3(2):84-7.
1997: MT O'Leary; William F Blakemore
Use of a rat Y chromosome probe to determine the long-term survival of glial cells transplanted into areas of CNS demyelination.
Journal of neurocytology 1997;26(4):191-206.
1997: J S McKay; William F Blakemore; Robin J M Franklin
The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS.
Neuropathology and applied neurobiology 1997;23(1):50-8.
1997: Nick D Jeffery; William F Blakemore
Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination.
Brain : a journal of neurology 1997;120 ( Pt 1)():27-37.
1997: Robin J M Franklin; William F Blakemore
Transplanting oligodendrocyte progenitors into the adult CNS.
Journal of anatomy 1997;190 ( Pt 1)():23-33.
1996: MP Targett; J Sussman; Neil Scolding; M T O'Leary; D A S Compston; William F Blakemore
Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain.
Neuropathology and applied neurobiology 1996;22(3):199-206.
1996: N J Olby; William F Blakemore
A new method of quantifying the extent of tissue loss following spinal cord injury in the rat.
Experimental neurology 1996;138(1):82-92.
1996: Robin J M Franklin; S A Bayley; William F Blakemore
Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord but not in normal spinal cord.
Experimental neurology 1996;137(2):263-76.
1995: William F Blakemore; N J Olby; Robin J M Franklin
The use of transplanted glial cells to reconstruct glial environments in the CNS.
Brain pathology (Zurich, Switzerland) 1995;5(4):443-50.
1995: Robin J M Franklin; William F Blakemore
Glial-cell transplantation and plasticity in the O-2A lineage--implications for CNS repair.
Trends in neurosciences 1995;18(3):151-6.
1995: William F Blakemore; A John Crang; Robin J M Franklin; K Tang; S Ryder
Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS.
Glia 1995;13(2):79-91.
1995: N J Olby; MT O'Leary; MP Targett; William F Blakemore
The effect of injection technique on the passive spread of astrocytes following transplantation into rat spinal cord white matter.
Restorative neurology and neuroscience 1995;7(3):171-4.
1995: Robin J M Franklin; S A Bayley; Richard Milner; Charles ffrench-Constant; William F Blakemore
Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter.
Glia 1995;13(1):39-44.
1994: William F Blakemore; Robin J M Franklin; A John Crang
Repair of demyelinated lesions by glial cell transplantation.
Journal of neurology 1994;242(1 Suppl 1):S61-3.
1994: M Jung; A John Crang; William F Blakemore; D Hoppe; Helmut Kettenmann; Jacqueline Trotter
In vitro and in vivo characterisation of glial cells immortalised with a temperature sensitive SV40 T antigen-containing retrovirus.
Journal of neuroscience research 1994;37(2):182-96.
1994: MP Targett; William F Blakemore
The use of xenografting to evaluate the remyelinating potential of glial cell cultures.
Eye (London, England) 1994;8 ( Pt 2)():238-44.
1993: Susan C Barnett; Robin J M Franklin; William F Blakemore
In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature-sensitive mutant gene of the SV40 large T antigen.
The European journal of neuroscience 1993;5(10):1247-60.
1993: Robin J M Franklin; William F Blakemore
Requirements for Schwann cell migration within CNS environments: a viewpoint.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1993;11(5):641-9.
1993: Jacqueline Trotter; A John Crang; Melitta Schachner; William F Blakemore
Lines of glial precursor cells immortalised with a temperature-sensitive oncogene give rise to astrocytes and oligodendrocytes following transplantation into demyelinated lesions in the central nervous system.
Glia 1993;9(1):25-40.
1993: Robin J M Franklin; A John Crang; William F Blakemore
The reconstruction of an astrocytic environment in glia-deficient areas of white matter.
Journal of neurocytology 1993;22(5):382-96.
1993: Andrew Groves; Susan C Barnett; Robin J M Franklin; A John Crang; M Mayer; William F Blakemore; Mark Noble
Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells.
Nature 1993;362(6419):453-5.
1993: Robin J M Franklin; A John Crang; William F Blakemore
The role of astrocytes in the remyelination of glia-free areas of demyelination.
Advances in neurology 1993;59():125-33.
1992: William F Blakemore
Transplanted cultured type-1 astrocytes can be used to reconstitute the glia limitans of the CNS: the structure which prevents Schwann cells from myelinating CNS axons.
Neuropathology and applied neurobiology 1992;18(5):460-6.
1992: A John Crang; Robin J M Franklin; William F Blakemore; Mark Noble; Susan C Barnett; Andrew Groves; Jacqueline Trotter; M Schachner
The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals.
Journal of neuroimmunology 1992;40(2-3):243-53.
1992: Robin J M Franklin; A John Crang; William F Blakemore
The behaviour of meningeal cells following glial cell transplantation into chemically-induced areas of demyelination in the CNS.
Neuropathology and applied neurobiology 1992;18(2):189-200.
1992: Robin J M Franklin; A John Crang; William F Blakemore
Type 1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the O-2A lineage.
Developmental neuroscience 1992;14(2):85-92.
1991: William F Blakemore; Robin J M Franklin
Transplantation of glial cells into the CNS.
Trends in neurosciences 1991;14(8):323-7.
1991: Robin J M Franklin; A John Crang; William F Blakemore
Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord.
Journal of neurocytology 1991;20(5):420-30.
1991: A John Crang; William F Blakemore
Remyelination of demyelinated rat axons by transplanted mouse oligodendrocytes.
Glia 1991;4(3):305-13.
1991: A John Crang; Robin J M Franklin; William F Blakemore; Jacqueline Trotter; M Schachner; Susan C Barnett; Mark Noble
Transplantation of normal and genetically engineered glia into areas of demyelination.
Annals of the New York Academy of Sciences 1991;633():563-5.
1990: A E Williams; William F Blakemore
Pathogenesis of meningitis caused by Streptococcus suis type 2.
The Journal of infectious diseases 1990;162(2):474-81.
1990: A E Williams; William F Blakemore
Pathology of Streptococcal meningitis following intravenous intracisternal and natural routes of infection.
Neuropathology and applied neurobiology 1990;16(4):345-56.
1990: William F Blakemore; A John Crang; Robin J M Franklin
Transplantation of glial cell cultures into areas of demyelination in the adult CNS.
Progress in brain research 1990;82():225-32.
1989: A John Crang; William F Blakemore
The effect of the number of oligodendrocytes transplanted into X-irradiated, glial-free lesions on the extent of oligodendrocyte remyelination.
Neuroscience letters 1989;103(3):269-74.
1989: William F Blakemore; A John Crang
The relationship between type-1 astrocytes, Schwann cells and oligodendrocytes following transplantation of glial cell cultures into demyelinating lesions in the adult rat spinal cord.
Journal of neurocytology 1989;18(4):519-28.
1989: R E McKerrell; William F Blakemore; M Fred Heath; J Plumb; M J Bennett; Rodney J Pollitt; Christopher J Danpure
Primary hyperoxaluria (L-glyceric aciduria) in the cat: a newly recognised inherited disease.
The Veterinary record 1989;125(2):31-4.
1989: William F Blakemore; B A Summers; J Sedgwick
Lymphocyte-myelin sheath interactions in acute experimental allergic encephalomyelitis.
Journal of neuroimmunology 1989;23(1):19-24.
1989: William F Blakemore; B A Summers; M G Appel
Evidence of oligodendrocyte infection and degeneration in canine distemper encephalomyelitis.
Acta neuropathologica 1989;77(5):550-3.
1989: Christopher J Danpure; P R Jennings; J Mistry; R A Chalmers; R E McKerrell; William F Blakemore; M Fred Heath
Enzymological characterization of a feline analogue of primary hyperoxaluria type 2: a model for the human disease.
Journal of inherited metabolic disease 1989;12(4):403-14.
1988: A E Williams; William F Blakemore; T J Alexander
A murine model of Streptococcus suis type 2 meningitis in the pig.
Research in veterinary science 1988;45(3):394-9.
1988: William F Blakemore; A John Crang
Extensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system.
Developmental neuroscience 1988;10(1):1-11.
1988: William F Blakemore; M Fred Heath; M J Bennett; C H Cromby; Rodney J Pollitt
Primary hyperoxaluria and L-glyceric aciduria in the cat.
Journal of inherited metabolic disease 1988;11 Suppl 2():215-7.