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William Blalock

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John G Shelton; William L Blalock; Edmund R White; Linda Steelman; James A McCubrey
Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells.
John G Shelton; Phillip W Moye; Linda Steelman; William L Blalock; John Lee; Richard A Franklin; Martin McMahon; James A McCubrey
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
Fumin Chang; Linda Steelman; John Lee; John G Shelton; Patrick M Navolanic; William L Blalock; Richard A Franklin; James A McCubrey
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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2004: John G Shelton; William L Blalock; Edmund R White; Linda Steelman; James A McCubrey
Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2004;3(4):503-12.
2003: John G Shelton; Phillip W Moye; Linda Steelman; William L Blalock; John Lee; Richard A Franklin; Martin McMahon; James A McCubrey
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
Leukemia 2003;17(9):1765-82.
2003: Fumin Chang; Linda Steelman; John Lee; John G Shelton; Patrick M Navolanic; William L Blalock; Richard A Franklin; James A McCubrey
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Leukemia 2003;17(7):1263-93.
2003: William L Blalock; Patrick M Navolanic; Linda Steelman; John G Shelton; Phillip W Moye; John Lee; Richard A Franklin; A Mirza; Martin McMahon; Martyn K White; James A McCubrey
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
Leukemia 2003;17(6):1058-67.
2003: John G Shelton; Linda Steelman; John Lee; Steven L Knapp; William L Blalock; Phillip W Moye; Richard A Franklin; Steven C Pohnert; Amer M Mirza; Martin McMahon; James A McCubrey
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.
Oncogene 2003;22(16):2478-92.
2003: Fumin Chang; John Lee; Patrick M Navolanic; Linda Steelman; John G Shelton; William L Blalock; Richard A Franklin; James A McCubrey
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
Leukemia 2003;17(3):590-603.
2003: Fumin Chang; Linda Steelman; John G Shelton; John Lee; Patrick M Navolanic; William L Blalock; Richard Franklin; James A McCubrey
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
International journal of oncology 2003;22(3):469-80.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by retroviral infection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():221-52.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by transfection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():203-20.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.
Methods in molecular biology (Clifton, N.J.) 2003;218():185-201.
2002: Oussama A Saleh; William L Blalock; Carlo Burrows; Linda Steelman; Parul D Doshi; John P McKearn; James A McCubrey
Enhanced ability of the progenipoietin-1 to suppress apoptosis in human hematopoietic cells.
International journal of molecular medicine 2002;10(4):385-94.
2001: James A McCubrey; William L Blalock; Oussama A Saleh; M Pearce; Carlo Burrows; Linda Steelman; John Lee; Richard A Franklin; Stephanie M Oberhaus; Phillip W Moye; Parul D Doshi; John P McKearn
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells.
Leukemia 2001;15(8):1203-16.
2001: William L Blalock; M Pearce; Fumin Chang; John Lee; Steven C Pohnert; Carlo Burrows; Linda Steelman; Richard A Franklin; Martin McMahon; James A McCubrey
Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
Leukemia 2001;15(5):794-807.
2001: James A McCubrey; John Lee; Linda Steelman; William L Blalock; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
Cancer detection and prevention 2001;25(4):375-93.
2001: James A McCubrey; Linda Steelman; William L Blalock; John Lee; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.
Advances in enzyme regulation 2001;41():289-323.
2000: Caroline R Weinstein-Oppenheimer; William L Blalock; Linda Steelman; Fumin Chang; James A McCubrey
The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
Pharmacology & therapeutics 2000;88(3):229-79.
2000: Caroline R Weinstein-Oppenheimer; Linda Steelman; P A Algate; William L Blalock; Carlo Burrows; PE Hoyle; John Lee; Phillip W Moye; John G Shelton; Richard Franklin; James A McCubrey
Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells.
Leukemia 2000;14(11):1921-38.
2000: William L Blalock; Phillip W Moye; Fumin Chang; M Pearce; Linda Steelman; Martin McMahon; James A McCubrey
Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
Leukemia 2000;14(6):1080-96.
2000: Phillip W Moye; William L Blalock; PE Hoyle; Fumin Chang; Richard A Franklin; Caroline R Weinstein-Oppenheimer; M Pearce; Linda Steelman; Martin McMahon; James A McCubrey
Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
Leukemia 2000;14(6):1060-79.
2000: PE Hoyle; Phillip W Moye; Linda Steelman; William L Blalock; Richard A Franklin; M Pearce; Holly Cherwinski; E Bosch; Martin McMahon; James A McCubrey
Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
Leukemia 2000;14(4):642-56.
2000: William L Blalock; M Pearce; Linda Steelman; Richard A Franklin; S A McCarthy; Holly Cherwinski; Martin McMahon; James A McCubrey
A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.
Oncogene 2000;19(4):526-36.
2000: James A McCubrey; Linda Steelman; Phillip W Moye; PE Hoyle; Caroline R Weinstein-Oppenheimer; Fumin Chang; M Pearce; Martyn K White; Richard Franklin; William L Blalock
Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.
Advances in enzyme regulation 2000;40():305-37.
1999: William L Blalock; Caroline R Weinstein-Oppenheimer; Fumin Chang; PE Hoyle; Xiao-Yang Wang; P A Algate; Richard A Franklin; Stephanie M Oberhaus; Linda Steelman; James A McCubrey
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs.
Leukemia 1999;13(8):1109-66.
1998: James A McCubrey; Linda Steelman; PE Hoyle; William L Blalock; Caroline R Weinstein-Oppenheimer; Richard A Franklin; Holly Cherwinski; E Bosch; Martin McMahon
Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells.
Leukemia 1998;12(12):1903-29.
1996: Linda Steelman; P A Algate; William L Blalock; Xiao-Yang Wang; K D Prevost; PE Hoyle; James A McCubrey
Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells.
Leukemia 1996;10(3):528-42.