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Manfred Schubert-Zsilavecz

Research Profile

Chemicals & Drugs

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High Pressure Liquid Chromatography

Anatomy

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Germany

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TOP 3
Daniel Merk; Manfred Schubert-Zsilavecz
Repairing mutated proteins - development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.
Estel la Buscató; Sabine Grösch; Bettina Hofmann; Astrid Kaiser; Edmund Kostewicz; Carmen B Rödl; Florian Rörsch; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Joanna M Wisniewska; Mario Wurglics; Astrid Brüggerhoff; Ewgenij Proschak
Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.
Daniel Flesch; Christina Lamers; Daniel Merk; Manfred Schubert-Zsilavecz
Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

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All Publications

2013: Daniel Merk; Manfred Schubert-Zsilavecz
Repairing mutated proteins - development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.
Expert opinion on drug discovery 2013;8(6):691-708.
2013: Estel la Buscató; Sabine Grösch; Bettina Hofmann; Astrid Kaiser; Edmund Kostewicz; Carmen B Rödl; Florian Rörsch; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Joanna M Wisniewska; Mario Wurglics; Astrid Brüggerhoff; Ewgenij Proschak
Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.
Future medicinal chemistry 2013;5(8):865-80.
2013: Daniel Flesch; Christina Lamers; Daniel Merk; Manfred Schubert-Zsilavecz
Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).
Expert opinion on therapeutic patents 2013;23(2):233-67.
2013: Christina Lamers; Daniel Flesch; Manfred Schubert-Zsilavecz; Daniel Merk
Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators.
Expert opinion on therapeutic patents 2013;23(1):47-77.
2013: Kathleen Gerbeth; Jan Hüsch; Manfred Schubert-Zsilavecz; Oliver Werz; Gert Fricker; Mona Abdel-Tawab
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
Fitoterapia 2013;84():99-106.
2013: Patchima Sithisarn; Martin Michaelis; Manfred Schubert-Zsilavecz; Jindrich Cinatl
Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells.
Antiviral research 2013;97(1):41-8.
2013: Jan Hüsch; Manfred Schubert-Zsilavecz; Carsten Skarke; Giovanni Appendino; Christian Artaria; Janine Bohnet; Gert Fricker; Mona Abdel-Tawab
Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
Fitoterapia 2013;84():89-98.
2012: Estel la Buscató; Manfred Schubert-Zsilavecz; Dieter Steinhilber; René Blöcher; Steffen Hahn; Franca-Maria Klingler; Christina Lamers; Ewgenij Proschak
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.
Journal of medicinal chemistry 2012;55(23):10771-5.
2012: A Paulke; Manfred Schubert-Zsilavecz; Gunter P Eckert; Mario Wurglics
Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin.
Die Pharmazie 2012;67(12):991-6.
2012: Kathleen Gerbeth; Jan Hüsch; Jürgen Meins; Antonietta Rossi; Lidia Sautebin; Manfred Schubert-Zsilavecz; Carsten Skarke; Oliver Werz; Katja Wiechmann; Jeffrey S Barrett; Mona Abdel-Tawab
Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats.
Planta medica 2012;78(18):1932-8.
2012: Jan Hüsch; Herbert Rebmann; Manfred Schubert-Zsilavecz; Constanze Setzer; Jürgen Zirkel; Gert Fricker; Kathleen Gerbeth; Mona Abdel-Tawab
Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
Journal of natural products 2012;75(10):1675-82.
2012: Daniel Merk; Manfred Schubert-Zsilavecz
Novel strategies to control lipid metabolism: can the antisense drug mipomersen fulfill the unmet need?
Future medicinal chemistry 2012;4(14):1773-5.
2012: Dieter Steinhilber; Manfred Schubert-Zsilavecz
[Editorial: Pharmazie in unserer Zeit 5/2012].
Pharmazie in unserer Zeit 2012;41(5):371.
2012: Meike Krzywon; Manfred Schubert-Zsilavecz; Thomas van der Burg; Uwe Fuhr; Mona Abdel-Tawab
Study on the dosing accuracy of commonly used disposable insulin pens.
Diabetes technology & therapeutics 2012;14(9):804-9.
2012: Matthias Gabler; Manfred Schubert-Zsilavecz
[Mechanism of action of paracetamol--further contribution to discovery].
Pharmazie in unserer Zeit 2012;41(4):272-4.
2012: Theo Dingermann; Manfred Schubert-Zsilavecz; Martin Schulz
[Editorial: Pharmazie in unserer Zeit 4/2012].
Pharmazie in unserer Zeit 2012;41(4):267.
2012: Christina Lamers; Manfred Schubert-Zsilavecz; Daniel Merk
Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present).
Expert opinion on therapeutic patents 2012;22(7):803-41.
2012: Ramona Steri; Janosch Achenbach; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Ewgenij Proschak
Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity.
Biochemical pharmacology 2012;83(12):1674-81.
2012: Daniel Merk; Manfred Schubert-Zsilavecz
[Non-agonist inhibitors of Cdk5-dependent phosphorylation of PPAR as insulin sensitizers in the future?].
Pharmazie in unserer Zeit 2012;41(3):182-3.
2012: Daniel Merk; Dieter Steinhilber; Manfred Schubert-Zsilavecz
Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators.
Future medicinal chemistry 2012;4(8):1015-36.
2012: Florian Rörsch; Gisbert Schneider; Manfred Schubert-Zsilavecz; Estella Buscató; Klaus Deckmann; Gerd Geisslinger; Ewgenij Proschak; Sabine Grösch
Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).
Journal of medicinal chemistry 2012;55(8):3792-803.
2012: Daniel Merk; Manfred Schubert-Zsilavecz
Nuclear receptors as pharmaceutical targets: rise of FXR and rebirth of PPAR?
Future medicinal chemistry 2012;4(5):587-8.
2012: Bettina Hofmann; M Pellowska; Oliver Rau; G Schneider; Manfred Schubert-Zsilavecz; H Stark; M Wacker; Mario Wurglics; A Zivković; A S Kahnt; T J Maier; A A Michel; C B Rödl; K Awwad; I Fleming; M Hoffmann; Dieter Steinhilber
Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor.
British journal of pharmacology 2012;165(7):2304-13.
2012: Daniel Merk; Manfred Schubert-Zsilavecz
New hope or drawbacks: will chronic kidney disease be treatable with small molecules in the near future?
Future medicinal chemistry 2012;4(3):269-71.
2012: Martina Hieke; Bettina Hofmann; Estel la Buscató; Carmen B Rödl; Manfred Schubert-Zsilavecz; Holger Stark; Dieter Steinhilber; Joanna M Wisniewska; Ewgenij Proschak
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
Bioorganic & medicinal chemistry letters 2012;22(5):1969-75.
2011: Kathleen Gerbeth; Simon Kirste; Juergen Meins; Felix Momm; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2011;56(5):998-1005.
2011: Steffen Hahn; Jan Heering; Martina Hieke; Franca-Maria Klingler; Frank Loehr; Karin Meirer; Janosch Achenbach; Eduardo Barbosa-Sicard; Estella Buscató; Volker Doetsch; Ingrid Fleming; Mirjam Schroeder; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Ewgenij Proschak
Complementary screening techniques yielded fragments that inhibit the phosphatase activity of soluble epoxide hydrolase.
ChemMedChem 2011;6(12):2146-9.
2011: Manfred Schubert-Zsilavecz; Daniel Merk
Innovations in the treatment of cystic fibrosis: outriders for the treatment of diseases with other genetic defects?
Future medicinal chemistry 2011;3(16):1969-70.
2011: Jan Hüsch; C C Müller-Goymann; Herbert Rebmann; Martin U Schmidt; Gisbert Schneider; Manfred Schubert-Zsilavecz; Constanze Setzer; Jürgen Zirkel; Bercem Dutagaci; Lothar Fink; Tim Geppert; Clemens Glaubitz; Meike Harms; Mona Abdel-Tawab
Structural properties of so-called NSAID-phospholipid-complexes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;44(1-2):103-16.
2011: Martina Hieke; Julia Ness; Manfred Schubert-Zsilavecz; Ramona Steri; Sascha Weggen; Oliver Werz; Christine Greiner; Heiko Zettl
SAR studies of acidic dual γ-secretase/PPARγ modulators.
Bioorganic & medicinal chemistry 2011;19(18):5372-82.
2011: Christina Lamers; Manfred Schubert-Zsilavecz
[Success in the elucidation of receptor structure: medicinal chemistry of β (2)-agonists].
Pharmazie in unserer Zeit 2011;40(5):423-8.
2011: Manfred Schubert-Zsilavecz; Petra Högger
[Editorial: Pharmazie in unserer Zeit 5/2011].
Pharmazie in unserer Zeit 2011;40(5):371.
2011: M Revermann; R T Schermuly; Manfred Schubert-Zsilavecz; R Steri; Mario Wurglics; Ralf P Brandes; A S Fischer; Gerd Geisslinger; Thorsten J Maier; A Mieth; A Paulke; M Pellowska; L Popescu; Dieter Steinhilber
A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm.
British journal of pharmacology 2011;163(8):1721-32.
2011: Martina Hieke; Felix Reisen; Gisbert Schneider; Manfred Schubert-Zsilavecz; Michaela Dittrich; Christine Greiner; Oliver Werz
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
Journal of medicinal chemistry 2011;54(13):4490-507.
2011: Christine Greiner; Heiko Zettl; Andreas Koeberle; Carlo Pergola; Hinnak Northoff; Manfred Schubert-Zsilavecz; Oliver Werz
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.
Bioorganic & medicinal chemistry 2011;19(11):3394-401.
2011: Mona Abdel-Tawab; Oliver Werz; Manfred Schubert-Zsilavecz
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.
Clinical pharmacokinetics 2011;50(6):349-69.
2011: Martina Hieke; Christine Greiner; Theresa M Thieme; Manfred Schubert-Zsilavecz; Oliver Werz; Heiko Zettl
A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Bioorganic & medicinal chemistry letters 2011;21(5):1329-33.
2011: Kathleen Gerbeth; Jürgen Meins; Oliver Werz; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Determination of myrtucommulone from Myrtus communis in human and rat plasma by liquid chromatography/tandem mass spectrometry.
Planta medica 2011;77(5):450-4.
2011: Christian Ude; Alexander Paulke; Michael Nöldner; Manfred Schubert-Zsilavecz; Mario Wurglics
Plasma and brain levels of terpene trilactones in rats after an oral single dose of standardized Ginkgo biloba extract EGb 761®.
Planta medica 2011;77(3):259-64.
2011: Matthias Gabler; Manfred Schubert-Zsilavecz
Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121).
Molecules (Basel, Switzerland) 2011;16(12):10013-28.
2011: Manfred Schubert-Zsilavecz
[Message from the President].
Pharmazie in unserer Zeit 2011;40(1):2.
2010: Michaela Dittrich; Heiko Zettl; Manfred Schubert-Zsilavecz
Functionalization of fatty acid mimetics for solid-phase coupling and subsequent target identification.
Archiv der Pharmazie 2010;343(11-12):625-30.
2010: Klaus Deckmann; Florian Rörsch; Ramona Steri; Manfred Schubert-Zsilavecz; Gerd Geisslinger; Sabine Grösch
Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB.
Biochemical pharmacology 2010;80(9):1365-72.
2010: Laura Rangel-Ordóñez; Michael Nöldner; Manfred Schubert-Zsilavecz; Mario Wurglics
Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761®.
Planta medica 2010;76(15):1683-90.
2010: Manfred Schubert-Zsilavecz
[Treatment of erectile dysfunction].
Pharmazie in unserer Zeit 2010;39(5):385-90.
2010: Theo Dingermann; Manfred Schubert-Zsilavecz
[ Editorial. Pharmazie in unserer Zeit 5/2010].
Pharmazie in unserer Zeit 2010;39(5):331.
2010: Martina Hieke; Julia Ness; Ramona Steri; Michaela Dittrich; Christine Greiner; Oliver Werz; Karlheinz Baumann; Manfred Schubert-Zsilavecz; Sascha Weggen; Heiko Zettl
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Journal of medicinal chemistry 2010;53(12):4691-700.
2010: Ramona Steri; Matthias Rupp; Ewgenij Proschak; Timon Schroeter; Heiko Zettl; Katja Hansen; Oliver Schwarz; Lutz Müller-Kuhrt; Klaus-Robert Müller; Gisbert Schneider; Manfred Schubert-Zsilavecz
Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.
Bioorganic & medicinal chemistry letters 2010;20(9):2920-3.
2010: Theresa M Thieme; Ramona Steri; Ewgenij Proschak; Alexander Paulke; Gisbert Schneider; Manfred Schubert-Zsilavecz
Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Bioorganic & medicinal chemistry letters 2010;20(8):2469-73.
2010: Ramona Steri; Mahmut Kara; Ewgenij Proschak; Dieter Steinhilber; Gisbert Schneider; Manfred Schubert-Zsilavecz
Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription.
Future medicinal chemistry 2010;2(4):575-86.
2010: M Krzywon; Mona Abdel-Tawab; T van der Burg; U Fuhr; Manfred Schubert-Zsilavecz
Dosing accuracy of commonly used disposable insulin pens.
Current medical research and opinion 2010;26(4):901-5.
2010: Henning Blume; Manfred Schubert-Zsilavecz
[Editorial: Pharmazie in unserer Zeit 2/2010].
Pharmazie in unserer Zeit 2010;39(2):91.
2010: Ramona Steri; Manfred Schubert-Zsilavecz
[New classes of drugs in the pipeline. New in the treatment of diabetes mellitus].
Pharmazie in unserer Zeit 2010;39(2):142-6.
2010: Kerstin Sander; Yvonne von Coburg; Jean-Claude Camelin; Xavier Ligneau; Oliver Rau; Manfred Schubert-Zsilavecz; Jean-Charles Schwartz; Holger Stark
Acidic elements in histamine H(3) receptor antagonists.
Bioorganic & medicinal chemistry letters 2010;20(5):1581-4.
2010: Gunter P Eckert; Cornelia Franke; Michael Nöldner; Oliver Rau; Mario Wurglics; Manfred Schubert-Zsilavecz; Walter E Müller
Plant derived omega-3-fatty acids protect mitochondrial function in the brain.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;61(3):234-41.
2010: Andreas Koeberle; Antonietta Rossi; Heiko Zettl; Carlo Pergola; Friederike Dehm; Julia Bauer; Christine Greiner; Sina Reckel; Christina Hoernig; Hinnak Northoff; Frank Bernhard; Volker Dötsch; Lidia Sautebin; Manfred Schubert-Zsilavecz; Oliver Werz
The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
The Journal of pharmacology and experimental therapeutics 2010;332(3):840-8.
2010: Michael Lämmerhofer; Reinhard Pell; Marek Mahut; Martin Richter; Simone Schiesel; Heiko Zettl; Michaela Dittrich; Manfred Schubert-Zsilavecz; Wolfgang Lindner
Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers.
Journal of chromatography. A 2010;1217(7):1033-40.
2010: Matthias Rupp; Timon Schroeter; Ramona Steri; Heiko Zettl; Ewgenij Proschak; Katja Hansen; Oliver Rau; Oliver Schwarz; Lutz Müller-Kuhrt; Manfred Schubert-Zsilavecz; Klaus-Robert Müller; Gisbert Schneider
From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma.
ChemMedChem 2010;5(2):191-4.
2010: Heiko Zettl; Manfred Schubert-Zsilavecz; Dieter Steinhilber
Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors.
ChemMedChem 2010;5(2):179-85.
2010: Florian Rörsch; Ivonne Wobst; Heiko Zettl; Manfred Schubert-Zsilavecz; Sabine Grösch; Gerd Geisslinger; Gisbert Schneider; Ewgenij Proschak
Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.
Journal of medicinal chemistry 2010;53(2):911-5.
2010: Dorothee Lang; Christian Ude; Mario Wurglics; Manfred Schubert-Zsilavecz; Jochen Klein
Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2010;13(4):607-14.
2009: Daniel Poeckel; Christine Greiner; Carlo Pergola; Arne Henkel; Laura Popescu; Oliver Rau; Manfred Schubert-Zsilavecz; Oliver Werz
Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways.
European journal of pharmacology 2009;619(1-3):1-7.
2009: Heiko Zettl; Ramona Steri; Michael Lämmerhofer; Manfred Schubert-Zsilavecz
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.
Bioorganic & medicinal chemistry letters 2009;19(15):4421-6.
2009: Mathias Q Müller; Leo J de Koning; Andreas Schmidt; Christian Ihling; Yvonne Syha; Oliver Rau; Karl Mechtler; Manfred Schubert-Zsilavecz; Andrea Sinz
An innovative method to study target protein-drug interactions by mass spectrometry.
Journal of medicinal chemistry 2009;52(9):2875-9.
2009: Rüdiger Graf; Michael Kock; Andreas Bock; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Roland Kaufmann; Thomas Gassenmeier; Heike Beschmann; August Bernd; Stefan Kippenberger
Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes.
Experimental dermatology 2009;18(4):370-7.
2009: Phillip Krüger; Johanna Kanzer; Jessica Hummel; Gert Fricker; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;36(2-3):275-84.
2009: Yusuf Tanrikulu; Oliver Rau; Oliver Schwarz; Ewgenij Proschak; Karsten Siems; Lutz Müller-Kuhrt; Manfred Schubert-Zsilavecz; Gisbert Schneider
Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists.
Chembiochem : a European journal of chemical biology 2009;10(1):75-8.
2009: Christian Ude; Alexander Paulke; Manfred Schubert-Zsilavecz; Mario Wurglics
[Chemistry, pharmacokinetics and metabolism of ginkgo extract].
Pharmazie in unserer Zeit 2009;38(5):418-23.
2009: Theo Dingermann; Manfred Schubert-Zsilavecz
[ Editorial: Pharmazie in unserer Zeit 5/2009].
Pharmazie in unserer Zeit 2009;38(5):391.
2009: Heiko Zettl; Manfred Schubert-Zsilavecz
[Various therapy options. Medical Chemistry of platelet aggregation inhibitors].
Pharmazie in unserer Zeit 2009;38(4):314-9.
2009: Mona Abdel-Tawab; Heiko Zettl; Manfred Schubert-Zsilavecz
Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity.
Current medicinal chemistry 2009;16(16):2042-63.
2009: Christian Ude; Manfred Schubert-Zsilavecz
[Iron, calcium and magnesium salts].
Pharmazie in unserer Zeit 2009;38(3):224-31.
2009: Andreas Link; Manfred Schubert-Zsilavecz
[Pharmazie in unserer Zeit 3/2009].
Pharmazie in unserer Zeit 2009;38(3):201.
2009: Petra Schoettler; Theo Dingermann; Manfred Schubert-Zsilavecz
[Pharmazie in unserer Zeit 1/2009].
Pharmazie in unserer Zeit 2009;38(1):3.
2009: Ewgenij Proschak; Kerstin Sander; Heiko Zettl; Yusuf Tanrikulu; Oliver Rau; Petra Schneider; Manfred Schubert-Zsilavecz; Holger Stark; Gisbert Schneider
From molecular shape to potent bioactive agents II: fragment-based de novo design.
ChemMedChem 2009;4(1):45-8.
2009: Ewgenij Proschak; Heiko Zettl; Yusuf Tanrikulu; Martin Weisel; Jan M Kriegl; Oliver Rau; Manfred Schubert-Zsilavecz; Gisbert Schneider
From molecular shape to potent bioactive agents I: bioisosteric replacement of molecular fragments.
ChemMedChem 2009;4(1):41-4.
2008: Oliver Werz; Christine Greiner; Andreas Koeberle; Christina Hoernig; Sven George; Laura Popescu; Ivonne Syha; Manfred Schubert-Zsilavecz; Dieter Steinhilber
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
Journal of medicinal chemistry 2008;51(17):5449-53.
2008: Daniel Poeckel; Christine Greiner; Moritz Verhoff; Oliver Rau; Lars Tausch; Christina Hörnig; Dieter Steinhilber; Manfred Schubert-Zsilavecz; Oliver Werz
Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes.
Biochemical pharmacology 2008;76(1):91-7.
2008: Phillip Krüger; Rambod Daneshfar; Gunter P Eckert; Jochen Klein; Dietrich A Volmer; Ute Bahr; Walter E Müller; Michael Karas; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Metabolism of boswellic acids in vitro and in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1135-42.
2008: A Paulke; Michael Nöldner; Manfred Schubert-Zsilavecz; Mario Wurglics
St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses.
Die Pharmazie 2008;63(4):296-302.
2008: Oliver Rau; Yvonne Syha; Heiko Zettl; Michael Kock; Andreas Bock; Manfred Schubert-Zsilavecz
Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
Archiv der Pharmazie 2008;341(3):191-5.
2008: Oliver Rau; Heiko Zettl; Laura Popescu; Dieter Steinhilber; Manfred Schubert-Zsilavecz
The treatment of dyslipidemia--what's left in the pipeline?
ChemMedChem 2008;3(2):206-21.
2008: Holger Stark; Manfred Schubert-Zsilavecz
[Liebe Kolleginnen und Kollegen].
Pharmazie in unserer Zeit 2008;37(6):441.
2008: Kerstin Sander; Heiko Zettl; Manfred Schubert-Zsilavecz; Holger Stark
[Antitussives and expectorants].
Pharmazie in unserer Zeit 2008;37(6):462-71.
2008: Manfred Schubert-Zsilavecz; Theo Dingermann
[Statement of the DPhG: Opinion of the DPhG of the draft of a Law on genetic studies in humans (genetic diagnosis)].
Pharmazie in unserer Zeit 2008;37(5):425.
2008: Susanne Alban; Theo Dingermann; Henning Blume; Manfred Schubert-Zsilavecz
[Statement from the DPhG: DPhG opinion on the proposed health claims regulation].
Pharmazie in unserer Zeit 2008;37(5):424-5.
2008: Christian Ude; Manfred Schubert-Zsilavecz
[The medicinal chemistry of alpha 1 blockers].
Pharmazie in unserer Zeit 2008;37(4):284-8.
2008: Ramona Steri; Manfred Schubert-Zsilavecz
[High-throughput screening for inhibitors of bacterial transglycosylase].
Pharmazie in unserer Zeit 2008;37(4):278-9.
2008: Heiko Zettl; Manfred Schubert-Zsilavecz; Carsten D Siebert
[The medicinal chemistry of tricyclic antidepressives. Targets and stereochemistry].
Pharmazie in unserer Zeit 2008;37(3):206-13.
2008: Martina Hieke; Heiko Zettl; Manfred Schubert-Zsilavecz
[GPCR--structure of the human beta-2 receptor clarified].
Pharmazie in unserer Zeit 2008;37(3):191-2.
2008: Ulrike Holzgrabe; Manfred Schubert-Zsilavecz
[Helping ourselves to promote our scientific advancement].
Pharmazie in unserer Zeit 2008;37(1):97.
2007: K Griessmann; Astrid Kaunzinger; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
A rapid HPLC-UV method for the quantification of erythromycin in dermatological preparations.
Die Pharmazie 2007;62(9):668-71.
2007: Laura Popescu; Oliver Rau; Jark Böttcher; Yvonne Syha; Manfred Schubert-Zsilavecz
Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists.
Archiv der Pharmazie 2007;340(7):367-71.
2007: Heiko Zettl; Manfred Schubert-Zsilavecz; Carsten D Siebert
[From cocaine to innovative antiemetics. The medicinal chemistry of 5-ht3 receptor antagonists].
Pharmazie in unserer Zeit 2007;36(5):354-61.
2007: Oliver Rau; Heiko Zettl; Laura Popescu; Dieter Steinhilber; Manfred Schubert-Zsilavecz
[New targets and drugs for treatment of lipid metabolism disorders].
Pharmazie in unserer Zeit 2007;36(2):142-8.
2007: Dieter Steinhilber; Manfred Schubert-Zsilavecz
[Molecular pharmacology and medicinal chemistry of fibrate].
Pharmazie in unserer Zeit 2007;36(2):108-12.
2006: Swetlana Derksen; Oliver Rau; Petra Schneider; Manfred Schubert-Zsilavecz; Gisbert Schneider
Virtual screening for PPAR modulators using a probabilistic neural network.
ChemMedChem 2006;1(12):1346-50.
2006: Oliver Rau; Mario Wurglics; Theo Dingermann; Mona Abdel-Tawab; Manfred Schubert-Zsilavecz
Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.
Die Pharmazie 2006;61(11):952-6.
2006: Oliver Rau; Mario Wurglics; Alexander Paulke; Jessica Zitzkowski; Nadine Meindl; Andreas Bock; Theo Dingermann; Mona Abdel-Tawab; Manfred Schubert-Zsilavecz
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma.
Planta medica 2006;72(10):881-7.
2006: Sandra Ulrich; Stefan Loitsch; Oliver Rau; Andreas von Knethen; Bernhard Brüne; Manfred Schubert-Zsilavecz; Jürgen M Stein
Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism.
Cancer research 2006;66(14):7348-54.
2006: Claudia-Carolin Weber; Karen Reising; Walter E Müller; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Modulation of Pgp function by boswellic acids.
Planta medica 2006;72(6):507-13.
2006: Alexander Paulke; Manfred Schubert-Zsilavecz; Mario Wurglics
Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;832(1):109-13.
2006: Susanne Kreutz; Horst-Werner Korf; Manfred Schubert-Zsilavecz
[Selective cannabinoid receptor antagonists].
Pharmazie in unserer Zeit 2006;35(6):512-20.
2006: Ernst Mutschler; Manfred Schubert-Zsilavecz
[In].
Pharmazie in unserer Zeit 2006;35(6):471.
2006: Mario Wurglics; Manfred Schubert-Zsilavecz
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Clinical pharmacokinetics 2006;45(5):449-68.
2005: Karen Reising; Juergen Meins; Baerbel Bastian; Gunter Eckert; Walter E Mueller; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry.
Analytical chemistry 2005;77(20):6640-5.
2005: Leslie N Johnson-Anuna; Gunter P Eckert; Jan H Keller; Urule Igbavboa; Cornelia Franke; Thomas Fechner; Manfred Schubert-Zsilavecz; Michael Karas; Walter E Müller; W Gibson Wood
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex.
The Journal of pharmacology and experimental therapeutics 2005;312(2):786-93.
2005: P Pfuhl; U Kärcher; N Häring; Alwin Baumeister; Mona Abdel Tawab; Manfred Schubert-Zsilavecz
Simultaneous determination of niacin, niacinamide and nicotinuric acid in human plasma.
Journal of pharmaceutical and biomedical analysis 2005;36(5):1045-52.
2005: Manfred Schubert-Zsilavecz
[Cutaneous administration rather than swallowing].
Krankenpflege Journal 2005;43(7-10):186.
2005: Manfred Schubert-Zsilavecz; Holger Stark
[The medicinal chemistry of L-type calcium channel blockers].
Pharmazie in unserer Zeit 2005;34(5):374-9.
2005: H C Ernst Mutschler; Manfred Schubert-Zsilavecz
[Cardiovascular diseases, the most frequent cause of death].
Pharmazie in unserer Zeit 2005;34(5):359.
2005: Holger Stark; Yvonne Syha; Laura Popescu; Manfred Schubert-Zsilavecz
[New drugs for GERD treatment].
Pharmazie in unserer Zeit 2005;34(3):224-7.
2005: Manfred Schubert-Zsilavecz; Holger Stark
[Proton pump inhibitors].
Pharmazie in unserer Zeit 2005;34(3):194-9.
2005: Yvonne Syha; Laura Popescu; Mario Wurglics; Manfred Schubert-Zsilavecz
[The history of ulcer treatment].
Pharmazie in unserer Zeit 2005;34(3):188-92.
2004: Gunter P Eckert; Jan-Henning Keller; Claudia Jourdan; Michael Karas; Dietrich A Volmer; Manfred Schubert-Zsilavecz; Walter E Müller
Hyperforin modifies neuronal membrane properties in vivo.
Neuroscience letters 2004;367(2):139-43.
2004: S Schulte-Löbbert; Gisela Holoubek; Walter E Müller; Manfred Schubert-Zsilavecz; Mario Wurglics
Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products.
The Journal of pharmacy and pharmacology 2004;56(6):813-8.
2004: Manfred Schubert-Zsilavecz; Holger Stark
[Resumption-inhibition in presynaptic action: the medicinal].
Pharmazie in unserer Zeit 2004;33(4):282-7.
2004: Walter E Müller; Manfred Schubert-Zsilavecz
[Collagenin and collagen].
Pharmazie in unserer Zeit 2004;33(4):267.
2004: Holger Stark; Manfred Schubert-Zsilavecz
[Development, structures, and new trends. H1-antihistamines].
Pharmazie in unserer Zeit 2004;33(2):92-8.
2004: Anja Altmann; Daniel Poeckel; Lutz Fischer; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Oliver Werz
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.
British journal of pharmacology 2004;141(2):223-32.
2003: Jan-Henning Keller; Michael Karas; Walter E Müller; Dietrich A Volmer; Gunter P Eckert; Mona Abdel Tawab; Henning H Blume; Theo Dingermann; Manfred Schubert-Zsilavecz
Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry.
Analytical chemistry 2003;75(22):6084-8.
2003: S Schulte-Löbbert; Kerstin Westerhoff; A Wilke; Manfred Schubert-Zsilavecz; Mario Wurglics
Development of a high-performance-liquid-chromatographic method for the determination of biapigenin in biorelevant media.
Journal of pharmaceutical and biomedical analysis 2003;33(1):53-60.
2003: Mona Abdel Tawab; Ute Bahr; Michael Karas; Mario Wurglics; Manfred Schubert-Zsilavecz
Degradation of ginsenosides in humans after oral administration.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(8):1065-71.
2003: Walter Schunack; Manfred Schubert-Zsilavecz
[Regarding public health there is no doubt that in Germany and Europe that it is driven by economic considerations].
Pharmazie in unserer Zeit 2003;32(6):445.
2003: Theo Dingermann; Manfred Schubert-Zsilavecz
[Two classes of medicine: what are the consequences of treatment advances with new recombinant proteins?].
Pharmazie in unserer Zeit 2003;32(5):361.
2003: Mario Wurglics; Manfred Schubert-Zsilavecz
[Charge conformity and biopharmaceutic characterization. St. John's Wort extract preparations in comparison].
Pharmazie in unserer Zeit 2003;32(3):236-41.
2003: Theo Dingermann; Manfred Schubert-Zsilavecz
[St. John's wort flowers and basis for use...].
Pharmazie in unserer Zeit 2003;32(3):177.
2003: Karin Nemec; Manfred Schubert-Zsilavecz
[From teprotide to captopril. Rational design of ACE inhibitors].
Pharmazie in unserer Zeit 2003;32(1):11-6.
2003: Ernst Mutschler; Manfred Schubert-Zsilavecz
[Living collegenin and collagen].
Pharmazie in unserer Zeit 2003;32(1):5.
2002: Kerstin Westerhoff; Astrid Kaunzinger; Mario Wurglics; Jennifer B Dressman; Manfred Schubert-Zsilavecz
Biorelevant dissolution testing of St John's wort products.
The Journal of pharmacy and pharmacology 2002;54(12):1615-21.
2002: Astrid Kaunzinger; Alwin Baumeister; Klaus Cuda; Norbert Häring; Barbara S Schug; Henning H Blume; Klaus Raddatz; Gerhard Fischer; Manfred Schubert-Zsilavecz
Determination of 11-keto-boswellic acid in human plasma.
Journal of pharmaceutical and biomedical analysis 2002;28(3-4):729-39.
2002: Anja Altmann; Lutz Fischer; Manfred Schubert-Zsilavecz; Dieter Steinhilber; Oliver Werz
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization.
Biochemical and biophysical research communications 2002;290(1):185-90.
2002: Walter E Müller; Manfred Schubert-Zsilavecz
[Editorial: atypical neuroleptics].
Pharmazie in unserer Zeit 2002;31(6):523.
2002: Karin Nemec; Manfred Schubert-Zsilavecz
[Progress is nescessary! New antidementia drugs].
Pharmazie in unserer Zeit 2002;31(4):376-80.
2001: Mona Abdel Tawab; Astrid Kaunzinger; Ute Bahr; Michael Karas; Mario Wurglics; Manfred Schubert-Zsilavecz
Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma.
Journal of chromatography. B, Biomedical sciences and applications 2001;761(2):221-7.
2001: Mario Wurglics; Kerstin Westerhoff; Astrid Kaunzinger; A Wilke; Alwin Baumeister; Jennifer B Dressman; Manfred Schubert-Zsilavecz
Comparison of German St. John's wort products according to hyperforin and total hypericin content.
Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) 2001;41(4):560-6.
2001: Bruno Danieli; L Falcone; D Monti; Sergio Riva; S Gebhardt; Manfred Schubert-Zsilavecz
Regioselective enzymatic glycosylation of natural polyhydroxylated compounds: galactosylation and glucosylation of protopanaxatriol ginsenosides.
The Journal of organic chemistry 2001;66(1):262-9.
2001: Karin Nemec; Manfred Schubert-Zsilavecz
[Future therapies for metabolic bone diseases. New concepts and targets].
Pharmazie in unserer Zeit 2001;30(6):548-52.
2001: Karin Nemec; Manfred Schubert-Zsilavecz
[Current status of clinical usefulness. Bisphosphonates for treatment of bone diseases].
Pharmazie in unserer Zeit 2001;30(6):505-10.
2001: Ernst Mutschler; Manfred Schubert-Zsilavecz
[Risk factors in hypertension: a disease with fatal consequences].
Pharmazie in unserer Zeit 2001;30(4):279.
2001: Manfred Schubert-Zsilavecz; Mario Wurglics
[Better blood sugar control in diabetics. Insulin glargin--a long-acting insulin analogue].
Pharmazie in unserer Zeit 2001;30(2):125-30.
1999: S Steurer; Mario Wurglics; Werner Likussar; K Burmistrov; Astrid Michelitsch; Manfred Schubert-Zsilavecz
Lack of correlation between surface and interfacial activities of saponins and their hemolytic properties.
Die Pharmazie 1999;54(10):766-7.
1999: G Ollesch; Astrid Kaunzinger; D Juchelka; Manfred Schubert-Zsilavecz; Ulrich Ermler
Phospholipid bound to the flavohemoprotein from Alcaligenes eutrophus.
European journal of biochemistry / FEBS 1999;262(2):396-405.
1999: Bruno Danieli; M Luisetti; S Steurer; Astrid Michelitsch; Werner Likussar; Sergio Riva; J Reiner; Manfred Schubert-Zsilavecz
Application of lipase-catalyzed regioselective esterification in the preparation of digitonin derivatives.
Journal of natural products 1999;62(5):670-3.
1998: Franz Bucar; M Resch; Rudolf Bauer; M Burits; E Knauder; Manfred Schubert-Zsilavecz
5-Methylflavasperone and rhamnetin from Guiera senegalensis and their antioxidative and 5-lipoxygenase inhibitory activity.
Die Pharmazie 1998;53(12):875-8.
1998: Franz Bucar; S M Jachak; Y Noreem; T Kartnig; P Perera; Lars Bohlin; Manfred Schubert-Zsilavecz
Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis.
Planta medica 1998;64(4):373-4.
1995: Franz Bucar; T Kartnig; G Paschek; E Winkler; Manfred Schubert-Zsilavecz
Flavonoid glycosides from Lycopus europaeus.
Planta medica 1995;61(5):489.