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Christian Schudt

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Chemicals & Drugs

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Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Christian Schudt; Rolf Beume; Armin Hatzelmann; Hermann Tenor
Phosphodiesterase inhibitors: history of pharmacology.
Armin Hatzelmann; Esteban J Morcillo; Giuseppe Lungarella; Serge Adnot; Shahin Sanjar; Rolf Beume; Christian Schudt; Hermann Tenor
The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.

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All Publications

2011: Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Circulation 2011;123(11):1194-204.
2011: Christian Schudt; Rolf Beume; Armin Hatzelmann; Hermann Tenor
Phosphodiesterase inhibitors: history of pharmacology.
Handbook of experimental pharmacology 2011;(204):1-46.
2010: Armin Hatzelmann; Esteban J Morcillo; Giuseppe Lungarella; Serge Adnot; Shahin Sanjar; Rolf Beume; Christian Schudt; Hermann Tenor
The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.
Pulmonary pharmacology & therapeutics 2010;23(4):235-56.
2009: Martin Witzenrath; Birgitt Gutbier; Bernd Schmeck; Herrmann Tenor; Joachim Seybold; Raimund Kuelzer; Guido Grentzmann; Armin Hatzelmann; Vincent van Laak; Thomas Tschernig; Tim Mitchell; Christian Schudt; Simone Rosseau; Norbert Suttorp; Hartwig Schütte
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia.
Critical care medicine 2009;37(2):584-90.
2008: Eva Dony; Y-J Lai; Rio Dumitrascu; Soni Pullamsetti; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; D Flockerzi; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
The European respiratory journal 2008;31(3):599-610.
2007: Maria-Jesus Sanz; Julio Cortijo; M A Taha; Miguel Cerdá-Nicolás; E Schatton; B Burgbacher; J Klar; Hermann Tenor; Christian Schudt; Andrew C Issekutz; Armin Hatzelmann; Esteban J Morcillo
Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability.
British journal of pharmacology 2007;152(4):481-92.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Grazyna Kwapiszewska; Rio Dumitrascu; Xia Tian; Norbert Weissmann; Hossein A Ghofrani; Christina Kaulen; Torsten R Dunkern; Christian Schudt; Robert Voswinckel; Jiang Zhou; Arun Samidurai; Walter Klepetko; Renate Paddenberg; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Circulation 2007;115(17):2331-9.
2006: Anna Mais; Thomas Klein; Volker Ullrich; Christian Schudt; Gereon Lauer
Prostanoid pattern and iNOS expression during chondrogenic differentiation of human mesenchymal stem cells.
Journal of cellular biochemistry 2006;98(4):798-809.
2006: Natascha Hermann-Kleiter; Nikolaus Thuille; Christa Pfeifhofer; Thomas Gruber; Michaela Schäfer; Christof Zitt; Armin Hatzelmann; Christian Schudt; Michael Leitges; Gottfried Baier
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Blood 2006;107(12):4841-8.
2006: Soni Pullamsetti; Daniel Maring; Hossein A Ghofrani; Konstantin Mayer; Norbert Weissmann; Bernhard Rosengarten; Martin Lehner; Christian Schudt; Rainer Boer; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Thrombosis and haemostasis 2006;95(4):720-7.
2005: Joachim Seybold; Dirk Thomas; Martin Witzenrath; Sengül Boral; Andreas C Hocke; Alexander Bürger; Armin Hatzelmann; Hermann Tenor; Christian Schudt; Matthias Krüll; Hartwig Schütte; Stefan Hippenstiel; Norbert Suttorp
Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability.
Blood 2005;105(9):3569-76.
2005: Soni Pullamsetti; Stefanie Krick; Hüseyin Yilmaz; Hossein A Ghofrani; Christian Schudt; Norbert Weissmann; Beate Fuchs; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Respiratory research 2005;6():128.
2005: Norbert Weissmann; Nermin Kuzkaya; Beate Fuchs; Vedat Tiyerili; Rolf Schäfer; Hartwig Schütte; Hossein A Ghofrani; Ralph Theo Schermuly; Christian Schudt; Akylbek Sydykov; Bakytbek Egemnazarow; Werner Seeger; Friedrich Grimminger
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.
Respiratory research 2005;6():86.
2004: Ralph Theo Schermuly; Klaus Peter Kreisselmeier; Hossein A Ghofrani; Arun Samidurai; Soni Pullamsetti; Norbert Weissmann; Christian Schudt; Leander Ermert; Werner Seeger; Friedrich Grimminger
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Circulation research 2004;94(8):1101-8.
2003: Ralph Theo Schermuly; H Leuchte; Hossein A Ghofrani; Norbert Weissmann; Frank Rose; Markus G Kohstall; Horst Olschewski; Christian Schudt; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Zardaverine and aerosolised iloprost in a model of acute respiratory failure.
The European respiratory journal 2003;22(2):342-7.
2002: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; Norbert Weissmann; Christian Schudt; Hermann Tenor; Werner Seeger; Friedrich Grimminger
Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.
Critical care medicine 2002;30(11):2489-92.
2002: Hermann Tenor; Erik Hedbom; Hans Jörg Häuselmann; Christian Schudt; Armin Hatzelmann
Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes--functional importance of phosphodiesterase 4.
British journal of pharmacology 2002;135(3):609-18.
2001: Ralph Theo Schermuly; E Krupnik; Hermann Tenor; Christian Schudt; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Werner Seeger; Dieter Walmrath; Hossein A Ghofrani
Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity.
American journal of respiratory and critical care medicine 2001;164(9):1694-700.
2001: Armin Hatzelmann; Christian Schudt
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.
The Journal of pharmacology and experimental therapeutics 2001;297(1):267-79.
2000: R Hidi; S Timmermans; E Liu; Christian Schudt; Gordon Dent; Stephen T Holgate; R Djukanović
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
The European respiratory journal 2000;15(2):342-9.
2000: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; Christian Schudt; Hermann Tenor; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
The Journal of pharmacology and experimental therapeutics 2000;292(2):512-20.
1999: Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Christian Schudt; Dieter Walmrath
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1500-6.
1999: Florian Gantner; Christian Schudt; Albrecht Wendel; Armin Hatzelmann
Characterization of the phosphodiesterase (PDE) pattern of in vitro-generated human dendritic cells (DC) and the influence of PDE inhibitors on DC function.
Pulmonary pharmacology & therapeutics 1999;12(6):377-86.
1999: Christian Schudt; Florian Gantner; H Tenors; Armin Hatzelmann
Therapeutic potential of selective PDE inhibitors in asthma.
Pulmonary pharmacology & therapeutics 1999;12(2):123-9.
1998: Florian Gantner; C Götz; Volker Gekeler; Christian Schudt; Albrecht Wendel; Armin Hatzelmann
Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation.
British journal of pharmacology 1998;123(6):1031-8.
1998: Gordon Dent; S R White; Hermann Tenor; K Bodtke; Christian Schudt; Alan R Leff; Helgo Magnussen; Klaus F Rabe
Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors.
Pulmonary pharmacology & therapeutics 1998;11(1):47-56.
1997: Stefan Uhlig; Roland Featherstone; HD Held; R Nüsing; Christian Schudt; Albrecht Wendel
Attenuation by phosphodiesterase inhibitors of lipopolysaccharide-induced thromboxane release and bronchoconstriction in rat lungs.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1453-9.
1997: Florian Gantner; Hermann Tenor; Volker Gekeler; Christian Schudt; Albrecht Wendel; Armin Hatzelmann
Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study.
The Journal of allergy and clinical immunology 1997;100(4):527-35.
1997: Florian Gantner; R Kupferschmidt; Christian Schudt; Albrecht Wendel; Armin Hatzelmann
In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor-alpha release by PDE inhibitors.
British journal of pharmacology 1997;121(2):221-31.
1997: Florian Gantner; Sabine Küsters; Albrecht Wendel; Armin Hatzelmann; Christian Schudt; Gisa Tiegs
Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors.
The Journal of pharmacology and experimental therapeutics 1997;280(1):53-60.
1996: Hermann Tenor; Armin Hatzelmann; Martin K Church; Christian Schudt; Janis K Shute
Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects.
British journal of pharmacology 1996;118(7):1727-35.
1996: Armin Hatzelmann; D Haefner; R Beume; Christian Schudt
Automatic leukocyte differentiation in bronchoalveolar lavage fluids of guinea pigs and brown-Norway rats.
Journal of pharmacological and toxicological methods 1996;35(2):91-9.
1996: Norbert Suttorp; P Ehreiser; Stefan Hippenstiel; M Fuhrmann; Matthias Krüll; Hermann Tenor; Christian Schudt
Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4.
Lung 1996;174(3):181-94.
1995: Hermann Tenor; Armin Hatzelmann; R Kupferschmidt; L Stanciu; R Djukanović; Christian Schudt; Albrecht Wendel; Martin K Church; Janis K Shute
Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(7):625-33.
1995: Hermann Tenor; L Staniciu; Christian Schudt; Armin Hatzelmann; Albrecht Wendel; R Djukanović; Martin K Church; Janis K Shute
Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(7):616-24.
1995: Hermann Tenor; Armin Hatzelmann; Albrecht Wendel; Christian Schudt
Identification of phosphodiesterase IV activity and its cyclic adenosine monophosphate-dependent up-regulation in a human keratinocyte cell line (HaCaT).
The Journal of investigative dermatology 1995;105(1):70-4.
1995: Christian Schudt; Hermann Tenor; Armin Hatzelmann
PDE isoenzymes as targets for anti-asthma drugs.
The European respiratory journal 1995;8(7):1179-83.
1995: Armin Hatzelmann; Hermann Tenor; Christian Schudt
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
British journal of pharmacology 1995;114(4):821-31.
1994: Klaus F Rabe; Hermann Tenor; Gordon Dent; Christian Schudt; M Nakashima; Helgo Magnussen
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
The American journal of physiology 1994;266(5 Pt 1):L536-43.
1993: W Fischer; Christian Schudt; Albrecht Wendel
Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice.
Biochemical pharmacology 1993;45(12):2399-404.
1993: Klaus F Rabe; Hermann Tenor; Gordon Dent; Christian Schudt; S Liebig; Helgo Magnussen
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
The American journal of physiology 1993;264(5 Pt 1):L458-64.
1993: Norbert Suttorp; U Weber; T Welsch; Christian Schudt
Role of phosphodiesterases in the regulation of endothelial permeability in vitro.
The Journal of clinical investigation 1993;91(4):1421-8.
1991: Christian Schudt; S Winder; S Forderkunz; Armin Hatzelmann; Volker Ullrich
Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(6):682-90.
1991: L Gaal; Christian Schudt; Peter Illes
Effects of phosphodiesterase inhibition on the excitability of hippocampal pyramidal neurons in vitro.
European journal of pharmacology 1991;202(1):117-20.
1991: Christian Schudt; S Winder; B Müller; D Ukena
Zardaverine as a selective inhibitor of phosphodiesterase isozymes.
Biochemical pharmacology 1991;42(1):153-62.
1991: U Kilian; R Beume; Manfrid Eltze; Dietrich Häfner; G Hanauer; Christian Schudt
Telenzepine and its enantiomers, M1-selective antimuscarinics, in guinea pig lung function tests.
Agents and actions. Supplements 1991;34():131-47.
1991: Christian Schudt; S Winder; Manfrid Eltze; U Kilian; R Beume
Zardaverine: a cyclic AMP specific PDE III/IV inhibitor.
Agents and actions. Supplements 1991;34():379-402.
1990: M Galvan; Christian Schudt
Actions of the phosphodiesterase inhibitor zardaverine on guinea-pig ventricular muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(2):221-7.
1990: Heinz Bönisch; R Boer; M Dobler; Christian Schudt
Pharmacological characterization of muscarine receptors of PC12 (rat phaeochromocytoma) cells.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(3):158-64.
1989: Ivo W Graziadei; G Zernig; A Grassegger; R Boer; Christian Schudt; Hartmut Glossmann
Hydrophobic calcium channel ligands: methodical problems and their solution.
The American journal of cardiology 1989;64(17):43I-50I.
1989: M Galvan; R Boer; Christian Schudt
Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia.
European journal of pharmacology 1989;167(1):1-10.
1989: Christian Schudt; R Boer; Manfrid Eltze; R Riedel; G Grundler; N J Birdsall
The affinity, selectivity and biological activity of telenzepine enantiomers.
European journal of pharmacology 1989;165(1):87-96.
1989: R Boer; A Grassegger; Christian Schudt; Hartmut Glossmann
(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors.
European journal of pharmacology 1989;172(2):131-45.
1989: U Kilian; R Beume; Manfrid Eltze; Christian Schudt
Is phosphodiesterase inhibition a relevant bronchospasmolytic principle?
Agents and actions. Supplements 1989;28():331-48.
1988: Christian Schudt; C Auriga; B Kinder; N J Birdsall
The binding of [3H]telenzepine to muscarinic acetylcholine receptors in calf forebrain.
European journal of pharmacology 1988;145(1):87-90.
1988: Christian Schudt; C Auriga; N J Birdsall; R Boer
Does the prolonged occupancy of M1 receptors by telenzepine protect them against the action of vagally released acetylcholine?
Pharmacology 1988;37 Suppl 1():32-9.
1987: W Bohnenkamp; Manfrid Eltze; K Heintze; W Kromer; R Riedel; Christian Schudt
Specificity of the substituted benzimidazole B 823-08: a prodrug for gastric proton pump inhibition.
Pharmacology 1987;34(5):269-78.
1986: W Beil; Manfrid Eltze; K Heintze; K Klemm; R Riedel; Christian Schudt; K F Sewing; A Simon
The sulphoxide moiety of substituted benzimidazoles is essential for inhibition of parietal cell K+/H+-ATPase.
British journal of pharmacology 1986;88(2):389-95.
1985: Manfrid Eltze; S Gönne; R Riedel; B Schlotke; Christian Schudt; W A Simon
Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug.
European journal of pharmacology 1985;112(2):211-24.