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John Schuetz

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Chandrima Sinha; Sunitha Yarlagadda; Weiqiang Zhang; Aixia Ren; John D Schuetz; Kavisha Arora; Satish Cheepala; Chang-Suk Moon; Anjaparavanda P Naren
Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.
Satish Cheepala; Jean-Sebastien Hulot; Jessica A Morgan; Anjaparavanda P Naren; Yassine Sassi; Weiqiang Zhang; John D Schuetz
Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.
Yu Fukuda; John D Schuetz
ABC transporters and their role in nucleoside and nucleotide drug resistance.

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2013: Chandrima Sinha; Sunitha Yarlagadda; Weiqiang Zhang; Aixia Ren; John D Schuetz; Kavisha Arora; Satish Cheepala; Chang-Suk Moon; Anjaparavanda P Naren
Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.
The Journal of biological chemistry 2013;288(6):3786-94.
2013: Satish Cheepala; Jean-Sebastien Hulot; Jessica A Morgan; Anjaparavanda P Naren; Yassine Sassi; Weiqiang Zhang; John D Schuetz
Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.
Annual review of pharmacology and toxicology 2013;53():231-53.
2012: Yu Fukuda; John D Schuetz
ABC transporters and their role in nucleoside and nucleotide drug resistance.
Biochemical pharmacology 2012;83(8):1073-83.
2011: Yu Fukuda; Lydia Aguilar-Bryan; Martine Vaxillaire; Aurelie Dechaume; Yao Wang; Michael Dean; karobi moitra; Joseph Bryan; John D Schuetz
Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.
The Journal of biological chemistry 2011;286(10):8481-92.
2011: Shinjiro Nagai; Kazumasa Takenaka; Deepa Nachagari; Charles Rose; Kali Domoney; Daxi Sun; Alex Sparreboom; John D Schuetz
Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity.
Cancer research 2011;71(5):1781-91.
2009: John Lynch; Yu Fukuda; Partha Krishnamurthy; Guoqing Du; John D Schuetz
Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins.
Cancer research 2009;69(13):5560-7.
2008: Partha Krishnamurthy; Matthias Schwab; Kazumasa Takenaka; Deepa Nachagari; Jessica Morgan; Mark Leslie; Weinan Du; Kelli Boyd; Meyling Cheok; Hiromitsu Nakauchi; Catia Marzolini; Richard B Kim; Balasubramanian Poonkuzhali; Erin G Schuetz; William Evans; Mary Relling; John D Schuetz
Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.
Cancer research 2008;68(13):4983-9.
2007: Chunying Li; Partha Krishnamurthy; Himabindu Penmatsa; Kevin L Marrs; XueQing Wang; Manuela Zaccolo; Kees Jalink; Min Li; Deborah J Nelson; John D Schuetz; Anjaparavanda P Naren
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.
Cell 2007;131(5):940-51.
2007: Catia Marzolini; Rommel G Tirona; Guillermo Gervasini; Balasubramanian Poonkuzhali; Mahfoud Assem; Wooin Lee; Brenda F Leake; John D Schuetz; Erin G Schuetz; Richard B Kim
A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1769-80.
2007: Kazumasa Takenaka; Jessica A Morgan; George L Scheffer; Masashi Adachi; Clinton F Stewart; Daxi Sun; Markos Leggas; Karin F K Ejendal; Christine A Hrycyna; John D Schuetz
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Cancer research 2007;67(14):6965-72.
2007: Partha Krishnamurthy; Tao Xie; John D Schuetz
The role of transporters in cellular heme and porphyrin homeostasis.
Pharmacology & therapeutics 2007;114(3):345-58.
2007: Cornelia J F De Wolf; Hiroaki Yamaguchi; Ingrid van der Heijden; peter wielinga; Stefanie L Hundscheid; Nobuhito Ono; George L Scheffer; Marcel de Haas; John D Schuetz; Jan Wijnholds; Piet Borst
cGMP transport by vesicles from human and mouse erythrocytes.
The FEBS journal 2007;274(2):439-50.
2006: Partha Krishnamurthy; Guoqing Du; Yu Fukuda; Daxi Sun; Janardhan Sampath; Kelly E Mercer; Junfeng Wang; Beatriz Sosa-Pineda; K Gopal Murti; John D Schuetz
Identification of a mammalian mitochondrial porphyrin transporter.
Nature 2006;443(7111):586-9.
2006: Ombretta Turriziani; Paolo Pagnotti; Alessandra Pierangeli; Federico Focher; Cinzia Baranello; Francesca Bellomi; Francesca Falasca; Jessica Morgan; John D Schuetz; Guido Antonelli
The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.
AIDS research and human retroviruses 2006;22(10):960-7.
2006: Jatinder Lamba; Xin Chen; Lu-Bin Lan; Jin Woo Kim; Xin Wei Wang; Mary Relling; Yasuda Kazuto; Paul B Watkins; Stephen Strom; Daxi Sun; John D Schuetz; Erin G Schuetz
Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.
Pharmacogenetics and genomics 2006;16(6):415-27.
2006: Markos Leggas; John C Panetta; Yanli Zhuang; John D Schuetz; Brad Johnston; Feng Bai; Brian P Sorrentino; Sheng Zhou; Peter J Houghton; Clinton F Stewart
Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.
Cancer research 2006;66(9):4802-7.
2006: Partha Krishnamurthy; John D Schuetz
Role of ABCG2/BCRP in biology and medicine.
Annual review of pharmacology and toxicology 2006;46():381-410.
2005: David Masson; Laurent Lagrost; Anne Athias; Philippe Gambert; Cynthia Brimer-Cline; Lubin Lan; John D Schuetz; Erin G Schuetz; Mahfoud Assem
Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2164-9.
2005: Partha Krishnamurthy; John D Schuetz
The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2005;18(4):349-58.
2004: Clinton F Stewart; Markos Leggas; John D Schuetz; John C Panetta; Pamela J Cheshire; Jennifer Peterson; Najat C Daw; Jesse J Jenkins; Richard Gilbertson; Glen S Germain; Franklin C Harwood; Peter J Houghton
Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice.
Cancer research 2004;64(20):7491-9.
2004: Markos Leggas; Masashi Adachi; George L Scheffer; Daxi Sun; peter wielinga; Guoqing Du; Kelly E Mercer; Yanli Zhuang; John C Panetta; Brad Johnston; Rik J Scheper; Clinton F Stewart; John D Schuetz
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.
Molecular and cellular biology 2004;24(17):7612-21.
2004: Partha Krishnamurthy; Douglas Ross; Takeo Nakanishi; Kimberly J Bailey-Dell; Sheng Zhou; Kelly E Mercer; Balázs Sarkadi; Brian P Sorrentino; John D Schuetz
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
The Journal of biological chemistry 2004;279(23):24218-25.
2004: Mahfoud Assem; Erin G Schuetz; Markos Leggas; Daxi Sun; Kazuto Yasuda; Glen Reid; Noam Zelcer; Masashi Adachi; Stephen Strom; Ronald M Evans; David D Moore; Piet Borst; John D Schuetz
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.
The Journal of biological chemistry 2004;279(21):22250-7.
2004: Peter J Houghton; Glen S Germain; Franklin C Harwood; John D Schuetz; Clinton F Stewart; Elisabeth Buchdunger; Peter Traxler
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.
Cancer research 2004;64(7):2333-7.
2003: Monika Wierdl; Amelia Wall; Christopher L Morton; Janardhan Sampath; Mary K Danks; John D Schuetz; Philip Potter
Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.
Molecular pharmacology 2003;64(2):279-88.
2003: Noam Zelcer; Glen Reid; peter wielinga; Annemieke Kuil; Ingrid van der Heijden; John D Schuetz; Piet Borst
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).
The Biochemical journal 2003;371(Pt 2):361-7.
2003: Monika Wierdl; Christopher L Morton; Linda C Harris; Mary K Danks; John D Schuetz; Philip Potter
p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).
The Journal of pharmacology and experimental therapeutics 2003;304(2):699-705.
2003: Jatinder Lamba; Masashi Adachi; Daxi Sun; Jaana Tammur; Erin G Schuetz; Rando Allikmets; John D Schuetz
Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons.
Human molecular genetics 2003;12(2):99-109.
2003: Charis P Zamber; Jatinder Lamba; Kazuto Yasuda; Jennifer Farnum; Kenneth E Thummel; John D Schuetz; Erin G Schuetz
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.
Pharmacogenetics 2003;13(1):19-28.
2002: peter wielinga; Glen Reid; Eric E Challa; Ingrid van der Heijden; Liesbeth Van Deemter; Marcel de Haas; CA Mol; Annemieke Kuil; E Groeneveld; John D Schuetz; Connie Brouwer; Ronney A De Abreu; Jan Wijnholds; Jos H Beijnen; Piet Borst
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.
Molecular pharmacology 2002;62(6):1321-31.
2002: Masashi Adachi; Glen Reid; John D Schuetz
Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5.
Advanced drug delivery reviews 2002;54(10):1333-42.
2002: Ombretta Turriziani; John D Schuetz; Federico Focher; Carolina Scagnolari; Janardhan Sampath; Masashi Adachi; Federica Bambacioni; Elisabetta Riva; Guido Antonelli
Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.
The Biochemical journal 2002;368(Pt 1):325-32.
2002: Masashi Adachi; Janardhan Sampath; Lu-Bin Lan; Daxi Sun; Philip Hargrove; Robin M Flatley; Ann Tatum; Mary Z Edwards; Michele Wezeman; Larry H Matherly; Richard Drake; John D Schuetz
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
The Journal of biological chemistry 2002;277(41):38998-9004.
2002: Kazuto Yasuda; Lu-Bin Lan; Dominique Sanglard; Katryn Furuya; John D Schuetz; Erin G Schuetz
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
The Journal of pharmacology and experimental therapeutics 2002;303(1):323-32.
2002: Sheng Zhou; John J Morris; Yuxiao Barnes; Lubin Lan; John D Schuetz; Brian P Sorrentino
Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12339-44.
2002: Erin G Schuetz; Lubin Lan; Kazuto Yasuda; Richard Kim; Thomas A Kocarek; John D Schuetz; Stephen Strom
Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents.
Molecular pharmacology 2002;62(3):439-45.
2002: Sean Ekins; Richard B Kim; Brenda F Leake; Anne H Dantzig; Erin G Schuetz; Lu-Bin Lan; Kazuto Yasuda; Robert L Shepard; Mark A Winter; John D Schuetz; James H Wikel; Steven A Wrighton
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
Molecular pharmacology 2002;61(5):974-81.
2002: Sean Ekins; Richard B Kim; Brenda F Leake; Anne H Dantzig; Erin G Schuetz; Lu-Bin Lan; Kazuto Yasuda; Robert L Shepard; Mark A Winter; John D Schuetz; James H Wikel; Steven A Wrighton
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Molecular pharmacology 2002;61(5):964-73.
2002: H Pasha Emadi-Konjin; Hui Zhang; Vasuki Anandan; Daxi Sun; John D Schuetz; Katryn Furuya
Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6.
Biochimica et biophysica acta 2002;1574(2):117-30.
2002: Janardhan Sampath; Masashi Adachi; Sigrid Hatse; Lieve Naesens; J Balzarini; Robin M Flatley; Larry H Matherly; John D Schuetz
Role of MRP4 and MRP5 in biology and chemotherapy.
AAPS pharmSci 2002;4(3):E14.
2001: Kenneth E Thummel; C Brimer; Kazuto Yasuda; J Thottassery; T Senn; Y Lin; H Ishizuka; Evan D Kharasch; John D Schuetz; Erin G Schuetz
Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
Molecular pharmacology 2001;60(6):1399-406.
2001: Erin G Schuetz; Stephen Strom; Kazuto Yasuda; V Lecureur; Mahfoud Assem; C Brimer; Jatinder Lamba; Richard B Kim; V Ramachandran; Bernard J Komoroski; Raman Venkataramanan; H Cai; C J Sinal; F J Gonzalez; John D Schuetz
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
The Journal of biological chemistry 2001;276(42):39411-8.
2001: Janardhan Sampath; Daxi Sun; Vincent J Kidd; Jose Grenet; A Gandhi; Linda H. Shapiro; Q Wang; Gerard P Zambetti; John D Schuetz
Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.
The Journal of biological chemistry 2001;276(42):39359-67.
2001: S Zhou; John D Schuetz; Kevin D Bunting; A M Colapietro; Janardhan Sampath; J J Morris; Irina Lagutina; Gerard C Grosveld; M Osawa; H Nakauchi; Brian P Sorrentino
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.
Nature medicine 2001;7(9):1028-34.
2001: Richard B Kim; Brenda F Leake; Edna F Choo; George K Dresser; S V Kubba; Ute I Schwarz; A Taylor; Hong-Guang Xie; J McKinsey; S Zhou; Lu-Bin Lan; John D Schuetz; Erin G Schuetz; Grant R Wilkinson
Identification of functionally variant MDR1 alleles among European Americans and African Americans.
Clinical pharmacology and therapeutics 2001;70(2):189-99.
2001: V Lecureur; JV Thottassery; Daxi Sun; Erin G Schuetz; J Lahti; Gerard P Zambetti; John D Schuetz
Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo.
Oncogene 2001;20(3):303-13.
2000: C Brimer; J T Dalton; Z Zhu; John D Schuetz; Kazuto Yasuda; E Vanin; Mary Relling; Y Lu; Erin G Schuetz
Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein.
Pharmaceutical research 2000;17(7):803-10.
2000: Erin G Schuetz; D R Umbenhauer; Kazuto Yasuda; C Brimer; L Nguyen; Mary Relling; John D Schuetz; A H Schinkel
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.
Molecular pharmacology 2000;57(1):188-97.
2000: V Lecureur; Daxi Sun; P Hargrove; Erin G Schuetz; Richard B Kim; Lu-Bin Lan; John D Schuetz
Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.
Molecular pharmacology 2000;57(1):24-35.
1999: John D Schuetz; MC Connelly; D Sun; S G Paibir; Patricia M Flynn; Ranga Srinivas; A Kumar; Arnold Fridland
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Nature medicine 1999;5(9):1048-51.
1999: V M Belkov; Eugene Y Krynetski; John D Schuetz; Yuri Yanishevski; E Masson; S Mathew; Susana Raimondi; Ching-Hon Pui; Mary Relling; William Evans
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.
Blood 1999;93(5):1643-50.
1999: JV Thottassery; Daxi Sun; Gerard P Zambetti; A Troutman; V P Sukhatme; Erin G Schuetz; John D Schuetz
Sp1 and egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene.
The Journal of biological chemistry 1999;274(5):3199-206.
1998: Erin G Schuetz; C Brimer; John D Schuetz
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.
Molecular pharmacology 1998;54(6):1113-7.
1998: Bart Lutterbach; D Sun; John D Schuetz; Scott W Hiebert
The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein.
Molecular and cellular biology 1998;18(6):3604-11.
1998: Erin G Schuetz; Kazuto Yasuda; K Arimori; John D Schuetz
Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene.
Archives of biochemistry and biophysics 1998;350(2):340-7.
1998: Michael Fessing; Eugene Y Krynetski; John D Schuetz; William Evans
Structural and functional analysis of the human TPMT gene promoter.
Advances in experimental medicine and biology 1998;431():315-8.
1997: Eugene Y Krynetski; Michael Fessing; CR Yates; D Sun; John D Schuetz; William Evans
Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library.
Pharmaceutical research 1997;14(12):1672-8.
1997: JV Thottassery; Gerard P Zambetti; K Arimori; Erin G Schuetz; John D Schuetz
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):11037-42.
1997: Katryn Furuya; G Bradley; Daxi Sun; E G Schuetz; John D Schuetz
Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis.
Cancer research 1997;57(17):3708-16.
1997: A J Galpin; John D Schuetz; E Masson; Yuri Yanishevski; T W Synold; Julio Barredo; Ching-Hon Pui; Mary Relling; William Evans
Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity.
Molecular pharmacology 1997;52(1):155-63.
1997: Katryn Furuya; JV Thottassery; Erin G Schuetz; M Sharif; John D Schuetz
Bromocriptine transcriptionally activates the multidrug resistance gene (pgp2/mdr1b) by a novel pathway.
The Journal of biological chemistry 1997;272(17):11518-25.
1996: Eugene Y Krynetski; H L Tai; C R Yates; Michael Fessing; T Loennechen; John D Schuetz; Mary Relling; William Evans
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Pharmacogenetics 1996;6(4):279-90.
1996: Erin G Schuetz; A H Schinkel; Mary Relling; John D Schuetz
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4001-5.
1996: Erin G Schuetz; William T Beck; John D Schuetz
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Molecular pharmacology 1996;49(2):311-8.
1996: John D Schuetz; Erin G Schuetz; JV Thottassery; P S Guzelian; S Strom; D Sun
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Molecular pharmacology 1996;49(1):63-72.
1996: E Masson; Timothy W Synold; Mary Relling; John D Schuetz; John T Sandlund; Ching-Hon Pui; William Evans
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.
Leukemia 1996;10(1):56-60.
1996: E Masson; Mary Relling; Timothy W Synold; Q Liu; John D Schuetz; John T Sandlund; Ching-Hon Pui; William Evans
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.
The Journal of clinical investigation 1996;97(1):73-80.
1995: John D Schuetz; Stephen C Strom; Erin G Schuetz
Induction of P-glycoprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells.
Journal of cellular physiology 1995;165(2):261-72.
1995: D S Sonnichsen; Q Liu; Erin G Schuetz; John D Schuetz; A Pappo; Mary Relling
Variability in human cytochrome P450 paclitaxel metabolism.
The Journal of pharmacology and experimental therapeutics 1995;275(2):566-75.
1995: Erin G Schuetz; Katryn Furuya; John D Schuetz
Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.
The Journal of pharmacology and experimental therapeutics 1995;275(2):1011-8.
1995: John D Schuetz; J A Silverman; JV Thottassery; Katryn Furuya; Erin G Schuetz
Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(10):1321-32.
1995: S S Ghosh; A K Basu; Shobha Ghosh; R Hagley; L Kramer; John D Schuetz; WM Grogan; P Guzelian; C O Watlington
Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats.
Biochemical pharmacology 1995;50(1):49-54.
1995: John D Schuetz; P S Guzelian
Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene.
Biochimica et biophysica acta 1995;1261(1):161-5.
1995: Eugene Y Krynetski; John D Schuetz; A J Galpin; Ching-Hon Pui; Mary Relling; William Evans
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):949-53.
1995: Erin G Schuetz; John D Schuetz; M T Thompson; R A Fisher; J R Madariage; Stephen C Strom
Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes.
Molecular carcinogenesis 1995;12(2):61-5.
1994: Katryn Furuya; Rolf Gebhardt; Erin G Schuetz; John D Schuetz
Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver.
Biochimica et biophysica acta 1994;1219(3):636-44.
1994: Mary Relling; J Nemec; Erin G Schuetz; John D Schuetz; F J Gonzalez; K R Korzekwa
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.
Molecular pharmacology 1994;45(2):352-8.
1994: John D Schuetz; D L Beach; P S Guzelian
Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.
Pharmacogenetics 1994;4(1):11-20.
1993: Erin G Schuetz; John D Schuetz; Stephen C Strom; M T Thompson; R A Fisher; D T Molowa; D Li; P S Guzelian
Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes.
Hepatology (Baltimore, Md.) 1993;18(5):1254-62.
1993: John D Schuetz; S Kauma; P S Guzelian
Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.
The Journal of clinical investigation 1993;92(2):1018-24.
1993: John D Schuetz; Erin G Schuetz
Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(1):31-40.
1992: Erin G Schuetz; John D Schuetz; WM Grogan; A Naray-Fejes-Toth; G Fejes-Toth; J Raucy; P Guzelian; K Gionela; C O Watlington
Expression of cytochrome P450 3A in amphibian, rat, and human kidney.
Archives of biochemistry and biophysics 1992;294(1):206-14.
1992: Hans-Joerg burgerh; John D Schuetz; Erin G Schuetz; P S Guzelian
Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2145-9.
1992: David C Spink; H P Eugster; D W Lincoln; John D Schuetz; Erin G Schuetz; J A Johnson; Laurence S Kaminsky; John F Gierthy
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA.
Archives of biochemistry and biophysics 1992;293(2):342-8.
1990: Hans-Joerg burgerh; Erin G Schuetz; John D Schuetz; P S Guzelian
Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes.
Archives of biochemistry and biophysics 1990;281(2):204-11.
1990: Erin G Schuetz; John D Schuetz; B May; P S Guzelian
Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.
The Journal of biological chemistry 1990;265(2):1188-92.
1989: John D Schuetz; D T Molowa; P S Guzelian
Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.
Archives of biochemistry and biophysics 1989;274(2):355-65.
1989: Larry H Matherly; John D Schuetz; E Westin; I David Goldman
A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.
Analytical biochemistry 1989;182(2):338-45.
1989: John D Schuetz; E H Westin; Larry H Matherly; R Pincus; Paul Steven Swerdlow; I David Goldman
Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.
The Journal of biological chemistry 1989;264(27):16261-7.
1988: John D Schuetz; Larry H Matherly; E H Westin; I David Goldman
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
The Journal of biological chemistry 1988;263(20):9840-7.
1988: John D Schuetz; K M Gorse; I David Goldman; E H Westin
Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.
The Journal of biological chemistry 1988;263(16):7708-12.