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Martin Schuler

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Martin Schuler
[Medical care of the cancer patient - Is it really so different?].
Daniel C Christoph; Wilfried E Eberhardt; Thomas Gauler; Biftu Hassan; Mathias Hoiczyk; Julia D Maltzman; Daniel J O'Shannessy; Martin Schuler; Cindy Tran; Jeremias Wohlschlaeger; Murry W Wynes; Bernadette Reyna Asuncion; Fred R Hirsch
Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed.
Benjamin Juntermanns; Hideo Andreas Baba; Ali Canbay; Guido Gerken; Matthias Heuer; Andreas Paul; Sonia Radunz; Henning Reis; Martin Schuler; Georgios Charalambos Sotiropoulos; Gernot M Kaiser
Comparison of the sixth and the seventh editions of the UICC classification for perihilar cholangiocarcinoma.

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All Publications

2013: Martin Schuler
[Medical care of the cancer patient - Is it really so different?].
Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen 2013;107(2):116-9.
2013: Daniel C Christoph; Wilfried E Eberhardt; Thomas Gauler; Biftu Hassan; Mathias Hoiczyk; Julia D Maltzman; Daniel J O'Shannessy; Martin Schuler; Cindy Tran; Jeremias Wohlschlaeger; Murry W Wynes; Bernadette Reyna Asuncion; Fred R Hirsch
Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(1):19-30.
2013: Benjamin Juntermanns; Hideo Andreas Baba; Ali Canbay; Guido Gerken; Matthias Heuer; Andreas Paul; Sonia Radunz; Henning Reis; Martin Schuler; Georgios Charalambos Sotiropoulos; Gernot M Kaiser
Comparison of the sixth and the seventh editions of the UICC classification for perihilar cholangiocarcinoma.
Annals of surgical oncology 2013;20(1):277-84.
2012: Daniel C Christoph; Wilfried E Eberhardt; Thomas Gauler; Rodrigo Hepp; Bernadette Reyna Asuncion; Xian Lu; Celine Mascaux; Volker Neumann; Martin Schuler; Georgios Stamatis; Andrea Tannapfel; Dirk Theegarten; Cindy Tran; Stefan Welter; Jeremias Wohlschlaeger; Murry W Wynes; Fred R Hirsch
Folylpoly-glutamate synthetase expression is associated with tumor response and outcome from pemetrexed-based chemotherapy in malignant pleural mesothelioma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(9):1440-8.
2012: Martin Schuler; Jochen Schütte; Martina Uttenreuther-Fischer; Sven Wind; Philipp Harter; Walter Jonat; Patrick Neven; Martine Piccart; Kurt Possinger; Marcus Schmidt; Ahmad Awada; Matthias W Beckmann; Tatiana Besse-Hammer; Jean Luc Canon; Jacques De Grève; Luc Dirix; Peter A Fasching; Frank Fleischer; Nina Gottschalk; Nadia Harbeck
A phase II trial to assess efficacy and safety of afatinib in extensively pretreated patients with HER2-negative metastatic breast cancer.
Breast cancer research and treatment 2012;134(3):1149-59.
2012: Johannes Meiler; Emmanuelle Wesarg; Frank Breitenbuecher; Melanie Guyot; Sandra Hoffarth; Yvonne Höhn; Martin Schuler
Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.
Journal of cancer research and clinical oncology 2012;138(8):1385-94.
2012: Mathias Hoiczyk; Konstantinos Iliodromitis; Thomas Konorza; Sebastian Philipp; Martin Schuler; Agnes Bankfalvi; Sebastian Bauer; Jan Mikael Gerl; Raimund Erbel
Intimal sarcoma of the pulmonary artery with unusual findings: a case report.
Clinical research in cardiology : official journal of the German Cardiac Society 2012;101(5):397-401.
2012: Boyka Markova; Martin Schuler; Patricia S Hähnel; Stephan Herbertz; Stefan Kasper; Frank Breitenbuecher
Pharmacologic inhibition of mTOR antagonizes the cytotoxic activity of pemetrexed in non-small cell lung cancer.
Journal of cancer research and clinical oncology 2012;138(4):545-54.
2011: Silvan Becker; Frank Breitenbuecher; Patricia S Hähnel; Sandra Hoffarth; Boyka Markova; Sina Pleiner; Lars Hennig Schmidt; Rainer Wiewrodt; Martin Schuler
Functional and clinical characterization of the putative tumor suppressor WWOX in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(12):1976-83.
2011: Marcus Schmidt; Ilka Brigitte Petry; Daniel Böhm; Antje Lebrecht; Christian von Törne; Susanne Gebhard; Aslihan Gerhold-Ay; Cristina Cotarelo; Marco Battista; Wiebke Schormann; Evgenia Freis; Silvia Selinski; Katja Ickstadt; Jörg Rahnenführer; Martin Sebastian; Martin Schuler; Heinz Koelbl; Mathias Gehrmann; Jan G Hengstler
Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer.
Breast cancer research and treatment 2011;125(3):637-46.
2011: Daniel C Christoph; Lukas Wittkowski; Jörg Stattaus; Christoph Pöttgen; Kathy Keyvani; Thomas C Gauler; Martin Schuler; Wilfried E E Eberhardt
Very late and isolated leptomeningeal relapse of a pulmonary adenocarcinoma presenting as dementia.
Onkologie 2011;34(6):316-20.
2010: Andreas-Claudius Hoffmann; Peter Wild; Christina Leicht; Simone Bertz; Kathleen D Danenberg; Peter V Danenberg; Robert Stöhr; Michael Stöckle; Jan Lehmann; Martin Schuler; Arndt Hartmann
MDR1 and ERCC1 expression predict outcome of patients with locally advanced bladder cancer receiving adjuvant chemotherapy.
Neoplasia (New York, N.Y.) 2010;12(8):628-36.
2010: Philipp Schütt; Birgit Schütt; Magdalena Switala; Sebastian Bauer; Georgios Stamatis; Bertram Opalka; Wilfried Eberhardt; Martin Schuler; Peter A Horn; Vera Rebmann
Prognostic relevance of soluble human leukocyte antigen-G and total human leukocyte antigen class I molecules in lung cancer patients.
Human immunology 2010;71(5):489-95.
2010: Maximilian J Waldner; Stefan Wirtz; Christoph Becker; Daniel Seidel; Ingrid Tubbe; Kyra Cappel; Patricia S Hähnel; Peter R Galle; Martin Schuler; Markus F Neurath
Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer.
Inflammatory bowel diseases 2010;16(4):559-67.
2010: Sebastian Bauer; Thomas Mühlenberg; Michael Leahy; Mathias Hoiczyk; Thomas Gauler; Martin Schuler; Leendert Looijenga
Therapeutic potential of Mdm2 inhibition in malignant germ cell tumours.
European urology 2010;57(4):679-87.
2010: Ilka Brigitte Petry; Esther Fieber; Marcus Schmidt; Mathias Gehrmann; Susanne Gebhard; Matthias Hermes; Wiebke Schormann; Silvia Selinski; Evgenia Freis; Holger Schwender; Marc Brulport; Katja Ickstadt; Jörg Rahnenführer; Lindsey Maccoux; Jonathan West; Heinz Kölbl; Martin Schuler; Jan G Hengstler
ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):451-60.
2008: Claudia Stolz; Georg Hess; Patricia S Hähnel; Florian Grabellus; Sandra Hoffarth; Kurt W Schmid; Martin Schuler
Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis.
Blood 2008;112(8):3312-21.
2008: Maike Sieben; Kerstin Herzer; Maja Zeidler; Vera Heinrichs; Barbara Leuchs; Martin Schuler; Jan-J Cornelis; Peter Galle; Jean Rommelaere; Markus Moehler
Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein.
World journal of gastroenterology : WJG 2008;14(24):3819-28.
2008: Patricia S Hähnel; Sonja Thaler; Edite Antunes; Christoph Huber; Matthias Theobald; Martin Schuler
Targeting AKT signaling sensitizes cancer to cellular immunotherapy.
Cancer research 2008;68(10):3899-906.
2008: Celio A Marques; Patricia S Hähnel; Catherine Wölfel; Sonja Thaler; Christoph Huber; Matthias Theobald; Martin Schuler
An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression.
Blood 2008;111(3):1413-9.
2008: Sandra Hoffarth; Alexander Zitzer; Rainer Wiewrodt; P S Hähnel; V Beyer; Andreas Kreft; Stefan Biesterfeld; Martin Schuler
pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer.
Cell death and differentiation 2008;15(1):161-70.
2007: Emmanuelle Wesarg; Sandra Hoffarth; Rainer Wiewrodt; Monika Kröll; Stefan Biesterfeld; Christoph Huber; Martin Schuler
Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.
International journal of cancer. Journal international du cancer 2007;121(11):2387-94.
2006: Georg Hess; Thomas Flohr; Karin Kolbe; Sarah Bonn; Martin Schuler; Hans Günter Derigs; Christoph Huber
Effect of rituximab on the long-term outcome after high-dose therapy for relapsed B-cell non-Hodgkin's lymphoma.
Annals of hematology 2006;85(11):769-79.
2006: Johannes Meiler; Martin Schuler
Therapeutic targeting of apoptotic pathways in cancer.
Current drug targets 2006;7(10):1361-9.
2006: Carl C Schimanski; R Bahre; Ines Gockel; A Müller; Kirsten Frerichs; V Hörner; Andreas Teufel; Nektaria Simiantonaki; Stefan Biesterfeld; Thomas Wehler; Martin Schuler; Tobias Achenbach; Theodor Junginger; Peter R Galle; Markus Moehler
Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4.
British journal of cancer 2006;95(2):210-7.
2005: Joshua C Goldstein; Cristina Muñoz-Pinedo; Jean-Ehrland Ricci; S R Adams; A Kelekar; Martin Schuler; Roger Y Tsien; Douglas R Green
Cytochrome c is released in a single step during apoptosis.
Cell death and differentiation 2005;12(5):453-62.
2005: Christoph Huber; N Bobek; Jürgen Kuball; S Thaler; Sandra Hoffarth; C Huber; Matthias Theobald; Martin Schuler
Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo.
Cell death and differentiation 2005;12(4):317-25.
2005: Martin Schuler; Douglas R Green
Transcription, apoptosis and p53: catch-22.
Trends in genetics : TIG 2005;21(3):182-7.
2005: Johanna E A Portielje; Wim H J Kruit; Anke J M Eerenberg; Martin Schuler; Alex Sparreboom; Cor H J Lamers; Jan W Gratama; Gerrit Stoter; Christoph Huber; C Erik Hack
Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant.
Cancer immunology, immunotherapy : CII 2005;54(1):37-43.
2004: Jerry E Chipuk; Tomomi Kuwana; Lisa Bouchier-Hayes; Nathalie M Droin; Donald D Newmeyer; Martin Schuler; Douglas R Green
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
Science (New York, N.Y.) 2004;303(5660):1010-4.
2003: Jerry E Chipuk; Ulrich Maurer; Douglas R Green; Martin Schuler
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.
Cancer cell 2003;4(5):371-81.
2003: Javorina Milosevic; Sandra Hoffarth; Claudia Huber; Martin Schuler
The DNA damage-induced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspases.
Oncogene 2003;22(44):6852-6.
2003: Martin Schuler; U Maurer; Joshua C Goldstein; F Breitenbücher; Sandra Hoffarth; Nigel Waterhouse; Douglas R Green
p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation.
Cell death and differentiation 2003;10(4):451-60.
2002: Jürgen Kuball; Martin Schuler; E Antunes Ferreira; Wolfgang Herr; M Neumann; L Obenauer-Kutner; L Westreich; Christoph Huber; Thomas Wölfel; Matthias Theobald
Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man.
Gene therapy 2002;9(13):833-43.
2002: Rammohan V Rao; susana castro-obregon; Harald Frankowski; Martin Schuler; Veronika Stoka; Gabriel del Rio; Dale E Bredesen; H Michael Ellerby
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.
The Journal of biological chemistry 2002;277(24):21836-42.
2002: Jürgen Kuball; Shu Fen Wen; Joachim Leissner; Derek Atkins; Patricia Meinhardt; Erlinda Quijano; Heidrun Engler; Beth Hutchins; Daniel Maneval; Michael J Grace; Mary Ann Fritz; Stephan Störkel; Joachim W Thüroff; Christoph Huber; Martin Schuler
Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(4):957-65.
2001: Jürgen Kuball; Christoph Huber; Martin Schuler
[Gene therapy of solid tumors].
Der Internist 2001;42(10):1321-7.
2001: BB Wolf; Martin Schuler; W Li; B Eggers-Sedlet; W Lee; Pankaj Tailor; P Fitzgerald; G B Mills; Douglas R Green
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.
The Journal of biological chemistry 2001;276(36):34244-51.
2001: Sebastian Kreiter; N Winkelmann; Peter M Schneider; Martin Schuler; Thomas Fischer; Andrew J Ullmann; Christoph Huber; Hans Günter Derigs; Karin Kolbe
Failure of sustained engraftment after non-myeloablative conditioning with low-dose TBI and T cell-reduced allogeneic peripheral stem cell transplantation.
Bone marrow transplantation 2001;28(2):157-61.
2001: Nigel Waterhouse; Joshua C Goldstein; O von Ahsen; Martin Schuler; Donald D Newmeyer; Douglas R Green
Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process.
The Journal of cell biology 2001;153(2):319-28.
2001: Martin Schuler; Richard Herrmann; J L De Greve; A K Stewart; U Gatzemeier; D J Stewart; L Laufman; Richard J Gralla; Jürgen Kuball; R Buhl; Claus Peter Heussel; Friedrich Kommoss; A P Perruchoud; F A Shepherd; Mary Ann Fritz; J A Horowitz; Christoph Huber; C Rochlitz
Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(6):1750-8.
2000: K C Zimmermann; Nigel Waterhouse; Joshua C Goldstein; Martin Schuler; Douglas R Green
Aspirin induces apoptosis through release of cytochrome c from mitochondria.
Neoplasia (New York, N.Y.) 2000;2(6):505-13.
2000: Martin Schuler; Ella Bossy-Wetzel; Joshua C Goldstein; Patrick Fitzgerald; Douglas R Green
p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.
The Journal of biological chemistry 2000;275(10):7337-42.
1999: Johanna E A Portielje; Wim H J Kruit; Martin Schuler; J Beck; Cor H J Lamers; Gerrit Stoter; Christoph Huber; M de Boer-Dennert; A Rakhit; Reinder L H Bolhuis; Walter Aulitzky
Phase I study of subcutaneously administered recombinant human interleukin 12 in patients with advanced renal cell cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):3983-9.
1999: BB Wolf; Martin Schuler; F Echeverri; Douglas R Green
Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.
The Journal of biological chemistry 1999;274(43):30651-6.
1999: U Brass; T Tretter; Folker Schneller; Martin Schuler; Christoph Huber; Christian Peschel
IFN-alpha stimulates proliferation and cytokine secretion of CD40-stimulated B cell chronic lymphocytic leukemia cells in vitro.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(4):335-43.
1999: Rainer Wiewrodt; Martin Schuler; C Huber; Roland Buhl
[Gene therapy in cancers of the lung and pleura].
Pneumologie (Stuttgart, Germany) 1999;53(3):176-84.
1999: Martin Schuler; T Tretter; Folker Schneller; Christoph Huber; Christian Peschel
Autocrine transforming growth factor-beta from chronic lymphocytic leukemia-B cells interferes with proliferative T cell signals.
Immunobiology 1999;200(1):128-39.
1998: Folker Schneller; Martin Schuler; K Schumacher; J Thaler; Christian Peschel; Christoph Huber; Walter Aulitzky
Idarubicin and intermediate-dose cytarabine for myeloid blast crisis of chronic myelogenous leukemia--results of a phase-II trial.
Annals of hematology 1998;77(5):225-9.
1998: T Tretter; Martin Schuler; Folker Schneller; U Brass; M Esswein; MJ Aman; Christoph Huber; Christian Peschel
Direct cellular interaction with activated CD4(+) T cells overcomes hyporesponsiveness of B-cell chronic lymphocytic leukemia in vitro.
Cellular immunology 1998;189(1):41-50.
1998: Martin Schuler; C Rochlitz; J A Horowitz; J Schlegel; A P Perruchoud; Friedrich Kommoss; C T Bolliger; H U Kauczor; P Dalquen; Mary Ann Fritz; S Swanson; Richard Herrmann; Christoph Huber
A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer.
Human gene therapy 1998;9(14):2075-82.
1998: Martin Schuler; U Bruntsch; Ernst Späth-Schwalbe; H Schrezenmeier; Christian Peschel; Lothar Färber; KJ Burger; Joachim Leissner; C Huber; Walter Aulitzky
Lack of efficacy of recombinant human interleukin-6 in patients with advanced renal cell cancer: results of a phase II study.
European journal of cancer (Oxford, England : 1990) 1998;34(5):754-6.
1996: Martin Schuler; Christian Peschel; Folker Schneller; Jan Fichtner; Lothar Färber; Christoph Huber; Walter Aulitzky
Immunomodulatory and hematopoietic effects of recombinant human interleukin-6 in patients with advanced renal cell cancer.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(11):903-10.
1995: Martin Schuler; Walter Aulitzky; Folker Schneller; Christian Peschel; Christoph Huber
[Interferon-alpha in therapy of malignant hemoblastoses].
Der Internist 1995;36(12):1133-8.
1995: H Schönbohn; Martin Schuler; Karin Kolbe; Christian Peschel; Christoph Huber; W Bemb; Walter Aulitzky
Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia.
Annals of hematology 1995;71(4):161-8.
1995: Martin Schuler; Christoph Huber; Christian Peschel
Cytokines in the pathophysiology and treatment of chronic B-cell malignancies. A review.
Annals of hematology 1995;71(2):57-63.
1994: Walter Aulitzky; Martin Schuler; Christian Peschel; Christoph Huber
Interleukins. Clinical pharmacology and therapeutic use.
Drugs 1994;48(5):667-77.