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Walter Schuler

Research Profile

Chemicals & Drugs

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Drug Dose Response Relationship

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T-Lymphocytes

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Publications

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Maurice J van Eis; Eric Vangrevelinghe; Juergen Wagner; Wilhelm Stark; Andre Strauss; Sandra W Cowan-Jacob; Jean-Pierre Evenou; Philipp Floersheim; Christoph Gaul; Anette von Matt; Lauren Monovich; Gabriele Rummel; Walter Schuler; Nicolas Soldermann
2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.
Tara L Naylor; Huaping Tang; Boris A Ratsch; Andreas Enns; Alice Loo; Liqing Chen; Peter Lenz; Nigel J Waters; Walter Schuler; Bernd Dörken; Yung-Mae Yao; Markus Warmuth; Georg Lenz; Frank Stegmeier
Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.
Rene Hersperger; Karl-Heinz Buchheit; Salvatore Cammisuli; Albert Enz; Olivier Lohse; Monique Ponelle; Walter Schuler; Alain Schweitzer; Christoph Walker; Hartmut Zehender; Gerhard Zenke; Alfred G Zimmerlin; Markus Zollinger; Lazzaro Mazzoni; John R Fozard
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.

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All Publications

2011: Maurice J van Eis; Eric Vangrevelinghe; Juergen Wagner; Wilhelm Stark; Andre Strauss; Sandra W Cowan-Jacob; Jean-Pierre Evenou; Philipp Floersheim; Christoph Gaul; Anette von Matt; Lauren Monovich; Gabriele Rummel; Walter Schuler; Nicolas Soldermann
2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.
Bioorganic & medicinal chemistry letters 2011;21(24):7367-72.
2011: Tara L Naylor; Huaping Tang; Boris A Ratsch; Andreas Enns; Alice Loo; Liqing Chen; Peter Lenz; Nigel J Waters; Walter Schuler; Bernd Dörken; Yung-Mae Yao; Markus Warmuth; Georg Lenz; Frank Stegmeier
Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.
Cancer research 2011;71(7):2643-53.
2004: Rene Hersperger; Karl-Heinz Buchheit; Salvatore Cammisuli; Albert Enz; Olivier Lohse; Monique Ponelle; Walter Schuler; Alain Schweitzer; Christoph Walker; Hartmut Zehender; Gerhard Zenke; Alfred G Zimmerlin; Markus Zollinger; Lazzaro Mazzoni; John R Fozard
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Journal of medicinal chemistry 2004;47(20):4950-7.
2004: Christoph Knosalla; Ryan David; Kathleen Moran; Bernd Gollackner; Walter Schuler; David H Sachs; Michel Awwad; Henk-Jan Schuurman; David K C Cooper
Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation.
Xenotransplantation 2004;11(4):353-60.
2004: Walter Schuler; Marc Bigaud; Volker Brinkmann; Franco E Di Padova; Sabine Geisse; Hermann Gram; Valerie Hungerford; Beate Kleuser; Colette Kristofic; Klaus Menninger; Reet Tees; Grazyna Wieczorek; Corinne Wilt; Catherine Wioland; Mauro Zurini
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.
Transplantation 2004;77(5):717-26.
2003: Miroslaw Majewski; Magdalena Korecka; Joanne Joergensen; Leona Fields; Plamen Kossev; Walter Schuler; Leslie Shaw; Mariusz A Wasik
Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses.
Transplantation 2003;75(10):1710-7.
2001: Gerhard Zenke; U Strittmatter; S Fuchs; Valerie QUESNIAUX; Volker Brinkmann; Walter Schuler; Mauro Zurini; Albert Enz; A Billich; JJ Sanglier; T Fehr
Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7165-71.
2000: Miroslaw Majewski; Magdalena Korecka; Plamen Kossev; Shiqing Li; J Goldman; J Moore; Leslie E Silberstein; Peter C Nowell; Walter Schuler; Leslie M Shaw; Mariusz A Wasik
The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4285-90.
2000: Henk-Jan Schuurman; Jan Ringers; Walter Schuler; Wim Slingerland; margreet jonker
Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation.
Transplantation 2000;69(5):737-42.
2000: Bernard Hausen; Jan F Gummert; Gerald J Berry; Uwe Christians; Natalie J Serkova; Tuija Ikonen; Laurie Hook; F Legay; Walter Schuler; MH Schreier; randall morris
Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin.
Transplantation 2000;69(4):488-96.
2000: Bernard Hausen; Tuija Ikonen; Norman P Briffa; Gerald J Berry; Uwe Christians; Robert C Robbins; Laurie Hook; Natalie J Serkova; Leslie Z Benet; Walter Schuler; randall morris
Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.
Transplantation 2000;69(1):76-86.
1999: Maximilian Grassberger; Thomas Baumruker; Albert Enz; Peter Hiestand; T Hultsch; Frank S Kalthoff; Walter Schuler; M Schulz; F J Werner; Anthony Winiski; B Wolff; Gerhard Zenke
A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology.
The British journal of dermatology 1999;141(2):264-73.
1999: JJ Sanglier; Valerie QUESNIAUX; T Fehr; H Hofmann; M Mahnke; Klaus Memmert; Walter Schuler; Gerhard Zenke; L Gschwind; Claudine Maurer; Wolfgang Schilling
Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity.
The Journal of antibiotics 1999;52(5):466-73.
1999: Richard Sedrani; L H Jones; A M Jutzi-Eme; Walter Schuler; Sylvain Cottens
Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity.
Bioorganic & medicinal chemistry letters 1999;9(3):459-62.
1999: Henk-Jan Schuurman; Charles Pally; Gisbert Weckbecker; Walter Schuler; Christian Bruns
SDZ RAD inhibits cold ischemia-induced vascular remodeling.
Transplantation proceedings 1999;31(1-2):1024-5.
1999: Rene Hersperger; Walter Schuler; Gerhard Zenke
Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin.
Bioorganic & medicinal chemistry letters 1999;9(2):227-32.
1998: Henk-Jan Schuurman; Walter Schuler; Jan Ringers; margreet jonker
The macrolide SDZ RAD is efficacious in a nonhuman primate model of allotransplantation.
Transplantation proceedings 1998;30(5):2198-9.
1998: Richard Sedrani; Sylvain Cottens; Joerg Kallen; Walter Schuler
Chemical modification of rapamycin: the discovery of SDZ RAD.
Transplantation proceedings 1998;30(5):2192-4.
1997: T Fehr; Valerie QUESNIAUX; JJ Sanglier; Lukas Oberer; L Gschwind; Monique Ponelle; Wolfgang Schilling; S Wehrli; Albert Enz; Gerhard Zenke; Walter Schuler
Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes.
The Journal of antibiotics 1997;50(11):893-9.
1997: Walter Schuler; Richard Sedrani; Sylvain Cottens; B Häberlin; M Schulz; Henk-Jan Schuurman; Gerhard Zenke; Hans-Günter Zerwes; MH Schreier
SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.
Transplantation 1997;64(1):36-42.
1997: Henk-Jan Schuurman; Sylvain Cottens; S Fuchs; Joanne Joergensen; T Meerloo; Richard Sedrani; M Tanner; Gerhard Zenke; Walter Schuler
SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.
Transplantation 1997;64(1):32-5.
1996: Henk-Jan Schuurman; J C Hengy; J Ringers; J Vonderscher; Walter Schuler; M Jonker
Neoral pharmacokinetics in cynomolgus monkeys: relation to efficacy in renal allografting.
Transplantation proceedings 1996;28(6):3142-4.
1996: T Fehr; JJ Sanglier; Walter Schuler; L Gschwind; M Ponelle; Wolfgang Schilling; C Wioland
Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain.
The Journal of antibiotics 1996;49(3):230-3.
1994: Valerie QUESNIAUX; S Wehrli; C Wioland; Walter Schuler; MH Schreier
Effects of rapamycin on hematopoiesis.
Transplantation proceedings 1994;26(6):3135-40.
1994: Valerie QUESNIAUX; S Wehrli; C Steiner; Joanne Joergensen; Henk-Jan Schuurman; P Herrman; MH Schreier; Walter Schuler
The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo.
Blood 1994;84(5):1543-52.