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Peter Schultz
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23
Ding, Sheng
23
Gray, Nathanael
14
Peters, Eric
12
Stevens, Raymond
12
Wu, Xu
11
Xie, Jianming
10
Wang, Lei
10
Orth, Anthony
10
Deniz, Ashok
9
Brock, Ansgar
9
Supekova, Lubica
9
Anderson, Christopher
8
Romesberg, Floyd
8
Su, Andrew
8
Geierstanger, Bernhard
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All Publications
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2009: Jones Christopher A; Nishiya Naoyuki; London Nyall R; Zhu Weiquan; Sorensen Lise K; Chan Aubrey C; Lim Chinten J; Chen Haoyu; Zhang Qisheng; Schultz Peter G; Hayallah Alaa M; Thomas Kirk R; Famulok Michael; Zhang Kang; Ginsberg Mark H; Li Dean Y
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.
Nature cell biology 2009;11(11):1325-31.
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2009: Zhu Shoutian; Wurdak Heiko; Wang Yan; Galkin Anna; Tao Haiyan; Li Jie; Lyssiotis Costas A; Yan Feng; Tu Buu P; Miraglia Loren; Walker John; Sun Fanxiang; Orth Anthony; Schultz Peter G; Wu Xu
A genomic screen identifies TYRO3 as a MITF regulator in melanoma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):17025-30.
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2009: Lemke Edward A; Gambin Yann; Vandelinder Virginia; Brustad Eric M; Liu Hsiao-Wei; Schultz Peter G; Groisman Alex; Deniz Ashok A
Microfluidic device for single-molecule experiments with enhanced photostability.
Journal of the American Chemical Society 2009;131(38):13610-2.
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2009: Liu Chang C; Choe Hyeryun; Farzan Michael; Smider Vaughn V; Schultz Peter G
Mutagenesis and evolution of sulfated antibodies using an expanded genetic code.
Biochemistry 2009;48(37):8891-8.
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2009: Lee Hyun Soo; Guo Jiantao; Lemke Edward A; Dimla Romerson D; Schultz Peter G
Genetic incorporation of a small, environmentally sensitive, fluorescent probe into proteins in Saccharomyces cerevisiae.
Journal of the American Chemical Society 2009;131(36):12921-3.
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2009: Wu Xu; Schultz Peter G
Synthesis at the interface of chemistry and biology.
Journal of the American Chemical Society 2009;131(35):12497-515.
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2009: Mills Jeremy H; Lee Hyun Soo; Liu Chang C; Wang Jiangyun; Schultz Peter G
A genetically encoded direct sensor of antibody-antigen interactions.
Chembiochem : a European journal of chemical biology 2009;10(13):2162-4.
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2009: Lee Hyun Soo; Dimla Romerson D; Schultz Peter G
Protein-DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid.
Bioorganic & medicinal chemistry letters 2009;19(17):5222-4.
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2009: Liu Chang C; Mack Antha V; Brustad Eric M; Mills Jeremy H; Groff Dan; Smider Vaughn V; Schultz Peter G
Evolution of proteins with genetically encoded "chemical warheads".
Journal of the American Chemical Society 2009;131(28):9616-7.
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2009: Melançon Charles E; Schultz Peter G
One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases.
Bioorganic & medicinal chemistry letters 2009;19(14):3845-7.
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2009: Lyssiotis Costas A; Foreman Ruth K; Staerk Judith; Garcia Michael; Mathur Divya; Markoulaki Styliani; Hanna Jacob; Lairson Luke L; Charette Bradley D; Bouchez Laure C; Bollong Michael; Kunick Conrad; Brinker Achim; Cho Charles Y; Schultz Peter G; Jaenisch Rudolf
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):8912-7.
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2009: Zhu Shoutian; Wurdak Heiko; Wang Jian; Lyssiotis Costas A; Peters Eric C; Cho Charles Y; Wu Xu; Schultz Peter G
A small molecule primes embryonic stem cells for differentiation.
Cell stem cell 2009;4(5):416-26.
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2009: Young Travis S; Ahmad Insha; Brock Ansgar; Schultz Peter G
Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris.
Biochemistry 2009;48(12):2643-53.
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2009: Grünewald Jan; Hunt Grady S; Dong Liqun; Niessen Frank; Wen Ben G; Tsao Meng-Lin; Perera Roshan; Kang Mingchao; Laffitte Bryan A; Azarian Sassan; Ruf Wolfram; Nasoff Marc; Lerner Richard A; Schultz Peter G; Smider Vaughn V
Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4337-42.
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2009: Wikoff William R; Anfora Andrew T; Liu Jun; Schultz Peter G; Lesley Scott A; Peters Eric C; Siuzdak Gary
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3698-703.
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2009: Peters Francis B; Brock Ansgar; Wang Jiangyun; Schultz Peter G
Photocleavage of the polypeptide backbone by 2-nitrophenylalanine.
Chemistry & biology 2009;16(2):148-52.
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2009: Lee Hyun Soo; Spraggon Glen; Schultz Peter G; Wang Feng
Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe.
Journal of the American Chemical Society 2009;131(7):2481-3.
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2009: Wang Weidong; Walker John R; Wang Xia; Tremblay Matthew S; Lee Jae Wook; Wu Xu; Schultz Peter G
Identification of small-molecule inducers of pancreatic beta-cell expansion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1427-32.
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2009: Lee Jongkook; Hong Jiyong; Nam Tae-Gyu; Peters Eric C; Orth Anthony P; Geierstanger Bernhard H; Goldfinger Lawrence E; Ginsberg Mark H; Cho Charles Y; Schultz Peter G
A small molecule inhibitor of alpha4 integrin-dependent cell migration.
Bioorganic & medicinal chemistry 2009;17(3):977-80.
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2009: Dubrovska Anna; Kim Sungeun; Salamone Richard J; Walker John R; Maira Sauveur-Michel; García-Echeverría Carlos; Schultz Peter G; Reddy Venkateshwar A
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):268-73.
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2009: Guo Jiantao; Melançon Charles E; Lee Hyun Soo; Groff Dan; Schultz Peter G
Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids.
Angewandte Chemie (International ed. in English) 2009;48(48):9148-51.
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2009: Chen Peng R; Groff Dan; Guo Jiantao; Ou Weijia; Cellitti Susan; Geierstanger Bernhard H; Schultz Peter G
A facile system for encoding unnatural amino acids in mammalian cells.
Angewandte Chemie (International ed. in English) 2009;48(22):4052-5.
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2009: Groff Dan; Thielges Megan C; Cellitti Susan; Schultz Peter G; Romesberg Floyd E
Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase.
Angewandte Chemie (International ed. in English) 2009;48(19):3478-81.
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2008: Brustad Eric M; Lemke Edward A; Schultz Peter G; Deniz Ashok A
A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer.
Journal of the American Chemical Society 2008;130(52):17664-5.
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2008: Liu Chang C; Mack Antha V; Tsao Meng-Lin; Mills Jeremy H; Lee Hyun Soo; Choe Hyeryun; Farzan Michael; Schultz Peter G; Smider Vaughn V
Protein evolution with an expanded genetic code.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17688-93.
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2008: Brustad Eric; Bushey Mark L; Brock Ansgar; Chittuluru Johnathan; Schultz Peter G
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins.
Bioorganic & medicinal chemistry letters 2008;18(22):6004-6.
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2008: Lee Hyun Soo; Schultz Peter G
Biosynthesis of a site-specific DNA cleaving protein.
Journal of the American Chemical Society 2008;130(40):13194-5.
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2008: Grünewald Jan; Tsao Meng-Lin; Perera Roshan; Dong Liqun; Niessen Frank; Wen Ben G; Kubitz Diane M; Smider Vaughn V; Ruf Wolfram; Nasoff Marc; Lerner Richard A; Schultz Peter G
Immunochemical termination of self-tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11276-80.
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2008: Plouffe David; Brinker Achim; McNamara Case; Henson Kerstin; Kato Nobutaka; Kuhen Kelli; Nagle Advait; Adrián Francisco; Matzen Jason T; Anderson Paul; Nam Tae-Gyu; Gray Nathanael S; Chatterjee Arnab; Janes Jeff; Yan S Frank; Trager Richard; Caldwell Jeremy S; Schultz Peter G; Zhou Yingyao; Winzeler Elizabeth A
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9059-64.
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2008: Cellitti Susan E; Jones David H; Lagpacan Leanna; Hao Xueshi; Zhang Qiong; Hu Huiyong; Brittain Scott M; Brinker Achim; Caldwell Jeremy; Bursulaya Badry; Spraggon Glen; Brock Ansgar; Ryu Youngha; Uno Tetsuo; Schultz Peter G; Geierstanger Bernhard H
In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.
Journal of the American Chemical Society 2008;130(29):9268-81.
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2008: Kato Nobutaka; Sakata Tomoyo; Breton Ghislain; Le Roch Karine G; Nagle Advait; Andersen Carsten; Bursulaya Badry; Henson Kerstin; Johnson Jeffrey; Kumar Kota Arun; Marr Felix; Mason Daniel; McNamara Case; Plouffe David; Ramachandran Vandana; Spooner Muriel; Tuntland Tove; Zhou Yingyao; Peters Eric C; Chatterjee Arnab; Schultz Peter G; Ward Gary E; Gray Nathanael; Harper Jeffrey; Winzeler Elizabeth A
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
Nature chemical biology 2008;4(6):347-56.
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2008: Debler Erik W; Kaufmann Gunnar F; Meijler Michael M; Heine Andreas; Mee Jenny M; Pljevaljcic Goran; Di Bilio Angel J; Schultz Peter G; Millar David P; Janda Kim D; Wilson Ian A; Gray Harry B; Lerner Richard A
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex.
Science (New York, N.Y.) 2008;319(5867):1232-5.
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2008: Graziano James J; Liu Wenshe; Perera Roshan; Geierstanger Bernhard H; Lesley Scott A; Schultz Peter G
Selecting folded proteins from a library of secondary structural elements.
Journal of the American Chemical Society 2008;130(1):176-85.
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2008: Supekova Lubica; Supek Frantisek; Lee Jongkook; Chen Shawn; Gray Nathanael; Pezacki John P; Schlapbach Achim; Schultz Peter G
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.
The Journal of biological chemistry 2008;283(1):29-36.
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2008: Brustad Eric; Bushey Mark L; Lee Jae Wook; Groff Dan; Liu Wenshe; Schultz Peter G
A genetically encoded boronate-containing amino acid.
Angewandte Chemie (International ed. in English) 2008;47(43):8220-3.
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2008: Guo Jiantao; Wang Jiangyun; Lee Jong Seok; Schultz Peter G
Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins.
Angewandte Chemie (International ed. in English) 2008;47(34):6399-401.
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2008: Guo Jiantao; Wang Jiangyun; Anderson J Christopher; Schultz Peter G
Addition of an alpha-hydroxy acid to the genetic code of bacteria.
Angewandte Chemie (International ed. in English) 2008;47(4):722-5.
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2007: Tippmann Eric M; Liu Wenshe; Summerer Daniel; Mack Antha V; Schultz Peter G
A genetically encoded diazirine photocrosslinker in Escherichia coli.
Chembiochem : a European journal of chemical biology 2007;8(18):2210-4.
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2007: Lemke Edward A; Summerer Daniel; Geierstanger Bernhard H; Brittain Scott M; Schultz Peter G
Control of protein phosphorylation with a genetically encoded photocaged amino acid.
Nature chemical biology 2007;3(12):769-72.
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2007: Lee Jongkook; Wu Xu; Pasca di Magliano Marina; Peters Eric C; Wang Yan; Hong Jiyong; Hebrok Metthias; Ding Sheng; Cho Charles Y; Schultz Peter G
A small-molecule antagonist of the hedgehog signaling pathway.
Chembiochem : a European journal of chemical biology 2007;8(16):1916-9.
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2007: Lyssiotis Costas A; Walker John; Wu Chunlei; Kondo Toru; Schultz Peter G; Wu Xu
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):14982-7.
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2007: Liu Chang C; Brustad Eric; Liu Wenshe; Schultz Peter G
Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.
Journal of the American Chemical Society 2007;129(35):10648-9.
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2007: Matsuda Shigeo; Fillo Jeremiah D; Henry Allison A; Rai Priyamrada; Wilkens Steven J; Dwyer Tammy J; Geierstanger Bernhard H; Wemmer David E; Schultz Peter G; Spraggon Glen; Romesberg Floyd E
Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs.
Journal of the American Chemical Society 2007;129(34):10466-73.
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2007: Chen Shawn; Schultz Peter G; Brock Ansgar
An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae.
Journal of molecular biology 2007;371(1):112-22.
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2007: Xie Jianming; Supekova Lubica; Schultz Peter G
A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli.
ACS chemical biology 2007;2(7):474-8.
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2007: Chen Shuibing; Takanashi Shinichi; Zhang Qisheng; Xiong Wen; Zhu Shoutian; Peters Eric C; Ding Sheng; Schultz Peter G
Reversine increases the plasticity of lineage-committed mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10482-7.
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2007: Zhang Qisheng; Major Michael B; Takanashi Shinichi; Camp Nathan D; Nishiya Naoyuki; Peters Eric C; Ginsberg Mark H; Jian Xiaoying; Randazzo Paul A; Schultz Peter G; Moon Randall T; Ding Sheng
Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7444-8.
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2007: Hong Jiyong; Lee Jongkook; Min Kyung Hoon; Walker John R; Peters Eric C; Gray Nathanael S; Cho Charles Y; Schultz Peter G
Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation.
ACS chemical biology 2007;2(3):171-5.
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2007: Liu Wenshe; Brock Ansgar; Chen Shuo; Chen Shuibing; Schultz Peter G
Genetic incorporation of unnatural amino acids into proteins in mammalian cells.
Nature methods 2007;4(3):239-44.
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2007: Macpherson Lindsey J; Dubin Adrienne E; Evans Michael J; Marr Felix; Schultz Peter G; Cravatt Benjamin F; Patapoutian Ardem
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
Nature 2007;445(7127):541-5.
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2007: Galkin Anna V; Melnick Jonathan S; Kim Sungjoon; Hood Tami L; Li Nanxin; Li Lintong; Xia Gang; Steensma Ruo; Chopiuk Greg; Jiang Jiqing; Wan Yongqin; Ding Peter; Liu Yi; Sun Fangxian; Schultz Peter G; Gray Nathanael S; Warmuth Markus
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):270-5.
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2007: Xie Jianming; Liu Wenshe; Schultz Peter G
A genetically encoded bidentate, metal-binding amino acid.
Angewandte Chemie (International ed. in English) 2007;46(48):9239-42.
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2007: Wang Jiangyun; Schiller Stefan M; Schultz Peter G
A biosynthetic route to dehydroalanine-containing proteins.
Angewandte Chemie (International ed. in English) 2007;46(36):6849-51.
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2007: Liu Wenshe; Alfonta Lital; Mack Antha V; Schultz Peter G
Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases.
Angewandte Chemie (International ed. in English) 2007;46(32):6073-5.
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2006: Mukherji Mridul; Brill Laurence M; Ficarro Scott B; Hampton Garret M; Schultz Peter G
A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.
Biochemistry 2006;45(51):15529-40.
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2006: Tian Feng; Debler Erik W; Millar David P; Deniz Ashok A; Wilson Ian A; Schultz Peter G
The effects of antibodies on stilbene excited-state energetics.
Angewandte Chemie (International ed. in English) 2006;45(46):7763-5.
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2006: Chen Shuibing; Do Jeong Tae; Zhang Qisheng; Yao Shuyuan; Yan Feng; Peters Eric C; Schöler Hans R; Schultz Peter G; Ding Sheng
Self-renewal of embryonic stem cells by a small molecule.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17266-71.
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2006: Liu Chang C; Schultz Peter G
Recombinant expression of selectively sulfated proteins in Escherichia coli.
Nature biotechnology 2006;24(11):1436-40.
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2006: Schultz Kathryn C; Supekova Lubica; Ryu Youngha; Xie Jianming; Perera Roshan; Schultz Peter G
A genetically encoded infrared probe.
Journal of the American Chemical Society 2006;128(43):13984-5.
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2006: Mukherji Mridul; Bell Russell; Supekova Lubica; Wang Yan; Orth Anthony P; Batalov Serge; Miraglia Loren; Huesken Dieter; Lange Joerg; Martin Christopher; Sahasrabudhe Sudhir; Reinhardt Mischa; Natt Francois; Hall Jonathan; Mickanin Craig; Labow Mark; Chanda Sumit K; Cho Charles Y; Schultz Peter G
Genome-wide functional analysis of human cell-cycle regulators.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14819-24.
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2006: Zeng Huaqiang; Xie Jianming; Schultz Peter G
Genetic introduction of a diketone-containing amino acid into proteins.
Bioorganic & medicinal chemistry letters 2006;16(20):5356-9.
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2006: Xie Jianming; Schultz Peter G
A chemical toolkit for proteins--an expanded genetic code.
Nature reviews. Molecular cell biology 2006;7(10):775-82.
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2006: Wang Jiangyun; Xie Jianming; Schultz Peter G
A genetically encoded fluorescent amino acid.
Journal of the American Chemical Society 2006;128(27):8738-9.
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2006: Summerer Daniel; Chen Shuo; Wu Ning; Deiters Alexander; Chin Jason W; Schultz Peter G
A genetically encoded fluorescent amino acid.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9785-9.
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2006: Berezhna Svitlana Y; Supekova Lubica; Supek Frantisek; Schultz Peter G; Deniz Ashok A
siRNA in human cells selectively localizes to target RNA sites.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7682-7.
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2006: Cho Charles Y; Koo Seung-Hoi; Wang Yan; Callaway Scott; Hedrick Susan; Mak Puiying A; Orth Anthony P; Peters Eric C; Saez Enrique; Montminy Marc; Schultz Peter G; Chanda Sumit K
Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling.
Cell metabolism 2006;3(5):367-78.
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2006: Turner James M; Graziano James; Spraggon Glen; Schultz Peter G
Structural plasticity of an aminoacyl-tRNA synthetase active site.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6483-8.
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2006: Tsao Meng-Lin; Summerer Daniel; Ryu Youngha; Schultz Peter G
The genetic incorporation of a distance probe into proteins in Escherichia coli.
Journal of the American Chemical Society 2006;128(14):4572-3.
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2006: Ryu Youngha; Schultz Peter G
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli.
Nature methods 2006;3(4):263-5.
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2006: Deiters Alexander; Groff Dan; Ryu Youngha; Xie Jianming; Schultz Peter G
A genetically encoded photocaged tyrosine.
Angewandte Chemie (International ed. in English) 2006;45(17):2728-31.
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2006: Collins Cynthia S; Hong Jiyong; Sapinoso Lisa; Zhou Yingyao; Liu Zheng; Micklash Kenneth; Schultz Peter G; Hampton Garret M
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3775-80.
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2006: Luesch Hendrik; Chanda Sumit K; Raya R Marina; DeJesus Paul D; Orth Anthony P; Walker John R; Izpisúa Belmonte Juan Carlos; Schultz Peter G
A functional genomics approach to the mode of action of apratoxin A.
Nature chemical biology 2006;2(3):158-67.
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2006: Melnick Jonathan S; Janes Jeff; Kim Sungjoon; Chang Jim Y; Sipes Daniel G; Gunderson Drew; Jarnes Laura; Matzen Jason T; Garcia Michael E; Hood Tami L; Beigi Ronak; Xia Gang; Harig Richard A; Asatryan Hayk; Yan S Frank; Zhou Yingyao; Gu Xiang-Ju; Saadat Alham; Zhou Vicki; King Frederick J; Shaw Christopher M; Su Andrew I; Downs Robert; Gray Nathanael S; Schultz Peter G; Warmuth Markus; Caldwell Jeremy S
An efficient rapid system for profiling the cellular activities of molecular libraries.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3153-8.
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2006: Sagan Selena M; Rouleau Yanouchka; Leggiadro Cynthia; Supekova Lubica; Schultz Peter G; Su Andrew I; Pezacki John Paul
The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(1):67-79.
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2006: Bose Mohua; Groff Dan; Xie Jianming; Brustad Eric; Schultz Peter G
The incorporation of a photoisomerizable amino acid into proteins in E. coli.
Journal of the American Chemical Society 2006;128(2):388-9.
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2006: Lowery Thomas J; Garcia Sandra; Chavez Lana; Ruiz E Janette; Wu Tom; Brotin Thierry; Dutasta Jean-Pierre; King David S; Schultz Peter G; Pines Alex; Wemmer David E
Optimization of xenon biosensors for detection of protein interactions.
Chembiochem : a European journal of chemical biology 2006;7(1):65-73.
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2006: Warashina Masaki; Min Kyung Hoon; Kuwabara Tomoko; Huynh Alexis; Gage Fred H; Schultz Peter G; Ding Sheng
A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells.
Angewandte Chemie (International ed. in English) 2006;45(4):591-3.
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2005: Tsao Meng-Lin; Tian Feng; Schultz Peter G
Selective Staudinger modification of proteins containing p-azidophenylalanine.
Chembiochem : a European journal of chemical biology 2005;6(12):2147-9.
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2005: Xie Jianming; Schultz Peter G
Adding amino acids to the genetic repertoire.
Current opinion in chemical biology 2005;9(6):548-54.
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2005: Turner James M; Graziano James; Spraggon Glen; Schultz Peter G
Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase.
Journal of the American Chemical Society 2005;127(43):14976-7.
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2005: Willingham A T; Orth A P; Batalov S; Peters E C; Wen B G; Aza-Blanc P; Hogenesch J B; Schultz P G
A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.
Science (New York, N.Y.) 2005;309(5740):1570-3.
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2005: Xie Jianming; Schultz Peter G
An expanding genetic code.
Methods (San Diego, Calif.) 2005;36(3):227-38.
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2005: Zhang Yan; Wang Lei; Schultz Peter G; Wilson Ian A
Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein science : a publication of the Protein Society 2005;14(5):1340-9.
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2005: Liu Jun; Wu Xu; Mitchell Brian; Kintner Chris; Ding Sheng; Schultz Peter G
A small-molecule agonist of the Wnt signaling pathway.
Angewandte Chemie (International ed. in English) 2005;44(13):1987-90.
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2005: Deiters Alexander; Schultz Peter G
In vivo incorporation of an alkyne into proteins in Escherichia coli.
Bioorganic & medicinal chemistry letters 2005;15(5):1521-4.
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2005: Liu Jun; Bang Anne G; Kintner Chris; Orth Anthony P; Chanda Sumit K; Ding Sheng; Schultz Peter G
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1927-32.
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2005: Luesch Hendrik; Wu Tom Y H; Ren Pingda; Gray Nathanael S; Schultz Peter G; Supek Frantisek
A genome-wide overexpression screen in yeast for small-molecule target identification.
Chemistry & biology 2005;12(1):55-63.
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2005: Deiters Alexander; Geierstanger Bernhard H; Schultz Peter G
Site-specific in vivo labeling of proteins for NMR studies.
Chembiochem : a European journal of chemical biology 2005;6(1):55-8.
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2005: Ding Sheng; Schultz Peter G
Small molecules and future regenerative medicine.
Current topics in medicinal chemistry 2005;5(4):383-95.
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2004: Venkateshrao Swarnalatha; Yin Jun; Jarzecki Andrzej A; Schultz Peter G; Spiro Thomas G
Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by Resonance Raman spectroscopy.
Journal of the American Chemical Society 2004;126(50):16361-7.
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2004: Tian Feng; Tsao Meng-Lin; Schultz Peter G
A phage display system with unnatural amino acids.
Journal of the American Chemical Society 2004;126(49):15962-3.
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2004: Xu Ran; Hanson Sarah R; Zhang Zhiwen; Yang Yu-Ying; Schultz Peter G; Wong Chi-Huey
Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli.
Journal of the American Chemical Society 2004;126(48):15654-5.
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2004: Cropp T Ashton; Schultz Peter G
An expanding genetic code.
Trends in genetics : TIG 2004;20(12):625-30.
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2004: Deiters Alexander; Cropp T Ashton; Summerer Daniel; Mukherji Mridul; Schultz Peter G
Site-specific PEGylation of proteins containing unnatural amino acids.
Bioorganic & medicinal chemistry letters 2004;14(23):5743-5.
-
2004: Spence Megan M; Ruiz E Janette; Rubin Seth M; Lowery Thomas J; Winssinger Nicolas; Schultz Peter G; Wemmer David E; Pines Alexander
Development of a functionalized xenon biosensor.
Journal of the American Chemical Society 2004;126(46):15287-94.
-
2004: Wu Ning; Deiters Alexander; Cropp T Ashton; King David; Schultz Peter G
A genetically encoded photocaged amino acid.
Journal of the American Chemical Society 2004;126(44):14306-7.
-
2004: Wu Xu; Walker John; Zhang Jie; Ding Sheng; Schultz Peter G
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
Chemistry & biology 2004;11(9):1229-38.
-
2004: Williams Bryn; Watanabe Coran M H; Schultz Peter G; Rimbach Gerald; Krucker Thomas
Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability.
Neurobiology of aging 2004;25(7):955-62.
-
2004: Ding Sheng; Schultz Peter G
A role for chemistry in stem cell biology.
Nature biotechnology 2004;22(7):833-40.
-
2004: Zhang Zhiwen; Alfonta Lital; Tian Feng; Bursulaya Badry; Uryu Sean; King David S; Schultz Peter G
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):8882-7.
-
2004: Anderson J Christopher; Wu Ning; Santoro Stephen W; Lakshman Vishva; King David S; Schultz Peter G
An expanded genetic code with a functional quadruplet codon.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7566-71.
-
2004: Yin Jun; Mills Jeremy H; Schultz Peter G
A catalysis-based selection for peroxidase antibodies with increased activity.
Journal of the American Chemical Society 2004;126(10):3006-7.
-
2004: Huang Qihong; Raya Angel; DeJesus Paul; Chao Sheng-Hao; Quon Kim C; Caldwell Jeremy S; Chanda Sumit K; Izpisua-Belmonte Juan C; Schultz Peter G
Identification of p53 regulators by genome-wide functional analysis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3456-61.
-
2004: Wu Xu; Ding Sheng; Ding Qiang; Gray Nathanael S; Schultz Peter G
Small molecules that induce cardiomyogenesis in embryonic stem cells.
Journal of the American Chemical Society 2004;126(6):1590-1.
-
2004: Zimmermann Nicole; Meggers Eric; Schultz Peter G
A second-generation copper(II)-mediated metallo-DNA-base pair.
Bioorganic chemistry 2004;32(1):13-25.
-
2004: Wignall Sarah M; Gray Nathanael S; Chang Young-Tae; Juarez Lolita; Jacob Richard; Burlingame Al; Schultz Peter G; Heald Rebecca
Identification of a novel protein regulating microtubule stability through a chemical approach.
Chemistry & biology 2004;11(1):135-46.
-
2004: Zhang Zhiwen; Gildersleeve Jeff; Yang Yu-Ying; Xu Ran; Loo Joseph A; Uryu Sean; Wong Chi-Huey; Schultz Peter G
A new strategy for the synthesis of glycoproteins.
Science (New York, N.Y.) 2004;303(5656):371-3.
-
2004: Chen Shuibing; Zhang Qisheng; Wu Xu; Schultz Peter G; Ding Sheng
Dedifferentiation of lineage-committed cells by a small molecule.
Journal of the American Chemical Society 2004;126(2):410-1.
-
2004: Wu Tom Y H; Hassig Christian; Wu Yiqin; Ding Sheng; Schultz Peter G
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Bioorganic & medicinal chemistry letters 2004;14(2):449-53.
-
2004: Zheng Lianxing; Liu Jun; Batalov Sergei; Zhou Demin; Orth Anthony; Ding Sheng; Schultz Peter G
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):135-40.
-
2003: Lowery Thomas J; Rubin Seth M; Ruiz E Janette; Spence Megan M; Winssinger Nicolas; Schultz Peter G; Pines Alexander; Wemmer David E
Applications of laser-polarized 129Xe to biomolecular assays.
Magnetic resonance imaging 2003;21(10):1235-9.
-
2003: Gildersleeve Jeff; Varvak Alex; Atwell Shane; Evans Doug; Schultz Peter G
Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases.
Angewandte Chemie (International ed. in English) 2003;42(48):5971-3.
-
2003: Alfonta Lital; Zhang Zhiwen; Uryu Sean; Loo Joseph A; Schultz Peter G
Site-specific incorporation of a redox-active amino acid into proteins.
Journal of the American Chemical Society 2003;125(48):14662-3.
-
2003: Santoro Stephen W; Anderson J Christopher; Lakshman Vishva; Schultz Peter G
An archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coli.
Nucleic acids research 2003;31(23):6700-9.
-
2003: Chanda Sumit K; White Suhaila; Orth Anthony P; Reisdorph Richard; Miraglia Loren; Thomas Russell S; DeJesus Paul; Mason Daniel E; Huang Qihong; Vega Raquel; Yu De-Hua; Nelson Christian G; Smith Brendan M; Terry Robert; Linford Alicia S; Yu Yang; Chirn Gung-wei; Song Chuanzheng; Labow Mark A; Cohen Dalia; King Frederick J; Peters Eric C; Schultz Peter G; Vogt Peter K; Hogenesch John B; Caldwell Jeremy S
Genome-scale functional profiling of the mammalian AP-1 signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12153-8.
-
2003: Wu Tom Y H; Schultz Peter G; Ding Sheng
One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines.
Organic letters 2003;5(20):3587-90.
-
2003: Deiters Alexander; Cropp T Ashton; Mukherji Mridul; Chin Jason W; Anderson J Christopher; Schultz Peter G
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae.
Journal of the American Chemical Society 2003;125(39):11782-3.
-
2003: Li Shuyu; Cutler Gene; Liu Jane Jijun; Hoey Timothy; Chen Liangbiao; Schultz Peter G; Liao Jiayu; Ling Xuefeng Bruce
A comparative analysis of HGSC and Celera human genome assemblies and gene sets.
Bioinformatics (Oxford, England) 2003;19(13):1597-605.
-
2003: Wu Tom Y H; Wagner Klaus W; Bursulaya Badry; Schultz Peter G; Deveraux Quinn L
Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction.
Chemistry & biology 2003;10(8):759-67.
-
2003: Chin Jason W; Cropp T Ashton; Anderson J Christopher; Mukherji Mridul; Zhang Zhiwen; Schultz Peter G
An expanded eukaryotic genetic code.
Science (New York, N.Y.) 2003;301(5635):964-7.
-
2003: Anderson J Christopher; Schultz Peter G
Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression.
Biochemistry 2003;42(32):9598-608.
-
2003: Yin Jun; Beuscher Albert E; Andryski Scott E; Stevens Raymond C; Schultz Peter G
Structural plasticity and the evolution of antibody affinity and specificity.
Journal of molecular biology 2003;330(4):651-6.
-
2003: Chin Jason W; Cropp T Ashton; Chu Stephanie; Meggers Eric; Schultz Peter G
Progress toward an expanded eukaryotic genetic code.
Chemistry & biology 2003;10(6):511-9.
-
2003: Ding Sheng; Wu Tom Y H; Brinker Achim; Peters Eric C; Hur Wooyoung; Gray Nathanael S; Schultz Peter G
Synthetic small molecules that control stem cell fate.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7632-7.
-
2003: Zhang Zhiwen; Smith Brian A C; Wang Lei; Brock Ansgar; Cho Charles; Schultz Peter G
A new strategy for the site-specific modification of proteins in vivo.
Biochemistry 2003;42(22):6735-46.
-
2003: Liao Jiayu; Schultz Peter G
Three sweet receptor genes are clustered in human chromosome 1.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(5):291-301.
-
2003: Matsuda Shigeo; Henry Allison A; Schultz Peter G; Romesberg Floyd E
The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs.
Journal of the American Chemical Society 2003;125(20):6134-9.
-
2003: Licht Stuart S; Sonnleitner Alois; Weiss Shimon; Schultz Peter G
A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis.
Biochemistry 2003;42(10):2916-25.
-
2003: Liu Haitian; Wang Lei; Brock Ansgar; Wong Chi-Huey; Schultz Peter G
A method for the generation of glycoprotein mimetics.
Journal of the American Chemical Society 2003;125(7):1702-3.
-
2003: Yin Jun; Andryski Scott E; Beuscher Albert E; Stevens Raymond C; Schultz Peter G
Structural evidence for substrate strain in antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):856-61.
-
2003: Mehl Ryan A; Anderson J Christopher; Santoro Stephen W; Wang Lei; Martin Andrew B; King David S; Horn David M; Schultz Peter G
Generation of a bacterium with a 21 amino acid genetic code.
Journal of the American Chemical Society 2003;125(4):935-9.
-
2003: Lin Qing; Barbas Carlos F; Schultz Peter G
Small-molecule switches for zinc finger transcription factors.
Journal of the American Chemical Society 2003;125(3):612-3.
-
2003: Salomon Arthur R; Ficarro Scott B; Brill Laurence M; Brinker Achim; Phung Qui T; Ericson Christer; Sauer Karsten; Brock Ansgar; Horn David M; Schultz Peter G; Peters Eric C
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):443-8.
-
2003: Wang Lei; Zhang Zhiwen; Brock Ansgar; Schultz Peter G
Addition of the keto functional group to the genetic code of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):56-61.
-
2003: Wang Lei; Xie Jianming; Deniz Ashok A; Schultz Peter G
Unnatural amino acid mutagenesis of green fluorescent protein.
The Journal of organic chemistry 2003;68(1):174-6.
-
2003: Wieland Stefan F; Vega Raquel G; Müller Rolf; Evans Claire F; Hilbush Brian; Guidotti Luca G; Sutcliffe J Gregor; Schultz Peter G; Chisari Francis V
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes.
Journal of virology 2003;77(2):1227-36.
-
2003: Santoro Stephen W; Schultz Peter G
Directed evolution of the substrate specificities of a site-specific recombinase and an aminoacyl-tRNA synthetase using fluorescence-activated cell sorting (FACS).
Methods in molecular biology (Clifton, N.J.) 2003;230():291-312.
-
2002: Wu Yiqin; Fa Ming; Tae Eunju Lee; Schultz Peter G; Romesberg Floyd E
Enzymatic phosphorylation of unnatural nucleosides.
Journal of the American Chemical Society 2002;124(49):14626-30.
-
2002: Chapman Eli; Ding Sheng; Schultz Peter G; Wong Chi-Huey
A potent and highly selective sulfotransferase inhibitor.
Journal of the American Chemical Society 2002;124(49):14524-5.
-
2002: Wu Xu; Ding Sheng; Ding Qiang; Gray Nathanael S; Schultz Peter G
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Journal of the American Chemical Society 2002;124(49):14520-1.
-
2002: Schultz Peter G; Yin Jun; Lerner Richard A
The chemistry of the antibody molecule.
Angewandte Chemie (International ed. in English) 2002;41(23):4427-37.
-
2002: Su Andrew I; Pezacki John P; Wodicka Lisa; Brideau Amy D; Supekova Lubica; Thimme Robert; Wieland Stefan; Bukh Jens; Purcell Robert H; Schultz Peter G; Chisari Francis V
Genomic analysis of the host response to hepatitis C virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15669-74.
-
2002: Zimmermann Nicole; Meggers Eric; Schultz Peter G
A novel silver(i)-mediated DNA base pair.
Journal of the American Chemical Society 2002;124(46):13684-5.
-
2002: Wu Tom Y H; Schultz Peter G
A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and beta-carbolines.
Organic letters 2002;4(23):4033-6.
-
2002: Chin Jason W; Schultz Peter G
In vivo photocrosslinking with unnatural amino Acid mutagenesis.
Chembiochem : a European journal of chemical biology 2002;3(11):1135-7.
-
2002: Yu Chengzhi; Henry Allison A; Romesberg Floyd E; Schultz Peter G
Polymerase recognition of unnatural base pairs.
Angewandte Chemie (International ed. in English) 2002;41(20):3841-4.
-
2002: Santoro Stephen W; Wang Lei; Herberich Brad; King David S; Schultz Peter G
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity.
Nature biotechnology 2002;20(10):1044-8.
-
2002: Chang Young-Tae; Choi Gildon; Bae Yoe-Sik; Burdett Matthew; Moon Ho-Sang; Lee Jae Wook; Gray Nathanael S; Schultz Peter G; Meijer Laurent; Chung Sung-Kee; Choi Kwan Yong; Suh Pann-Ghill; Ryu Sung Ho
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase.
Chembiochem : a European journal of chemical biology 2002;3(9):897-901.
-
2002: Zhang Zhiwen; Wang Lei; Brock Ansgar; Schultz Peter G
The selective incorporation of alkenes into proteins in Escherichia coli.
Angewandte Chemie (International ed. in English) 2002;41(15):2840-2.
-
2002: Su Andrew I; Guidotti Luca G; Pezacki John Paul; Chisari Francis V; Schultz Peter G
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11181-6.
-
2002: Winssinger Nicolas; Ficarro Scott; Schultz Peter G; Harris Jennifer L
Profiling protein function with small molecule microarrays.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11139-44.
-
2002: Li Shuyu; Liao Jiayu; Cutler Gene; Hoey Timothy; Hogenesch John B; Cooke Michael P; Schultz Peter G; Ling Xuefeng Bruce
Comparative analysis of human genome assemblies reveals genome-level differences.
Genomics 2002;80(2):138-9.
-
2002: Chin Jason W; Martin Andrew B; King David S; Wang Lei; Schultz Peter G
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11020-4.
-
2002: Schultz P G; Lerner R A
Completing the circle.
Nature 2002;418(6897):485.
-
2002: Chin Jason W; Santoro Stephen W; Martin Andrew B; King David S; Wang Lei; Schultz Peter G
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli.
Journal of the American Chemical Society 2002;124(31):9026-7.
-
2002: Supekova Lubica; Pezacki John Paul; Su Andrew I; Loweth Colin J; Riedl Rainer; Geierstanger Bernhard; Schultz Peter G; Wemmer David E
Genomic effects of polyamide/DNA interactions on mRNA expression.
Chemistry & biology 2002;9(7):821-7.
-
2002: Gildersleeve Jeff; Janes Jeff; Ulrich Helle; Yang Priscilla; Barbas Carlos; Schultz Peter G
Development of a genetic selection for catalytic antibodies.
Bioorganic & medicinal chemistry letters 2002;12(12):1691-4.
-
2002: Xia Gang; Chen Liangjing; Sera Takashi; Fa Ming; Schultz Peter G; Romesberg Floyd E
Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6597-602.
-
2002: Perez Omar D; Chang Young-Tae; Rosania Gustavo; Sutherlin Dan; Schultz Peter G
Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors.
Chemistry & biology 2002;9(4):475-83.
-
2002: Santoro Stephen W; Schultz Peter G
Directed evolution of the site specificity of Cre recombinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4185-90.
-
2002: Su Andrew I; Cooke Michael P; Ching Keith A; Hakak Yaron; Walker John R; Wiltshire Tim; Orth Anthony P; Vega Raquel G; Sapinoso Lisa M; Moqrich Aziz; Patapoutian Ardem; Hampton Garret M; Schultz Peter G; Hogenesch John B
Large-scale analysis of the human and mouse transcriptomes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4465-70.
-
2002: Ding Sheng; Gray Nathanael S; Ding Qiang; Wu Xu; Schultz Peter G
Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines.
Journal of combinatorial chemistry 2002;4(2):183-6.
-
2002: Chang Young-Tae; Choi Jaehwa; Ding Sheng; Prieschl Eva E; Baumruker Thomas; Lee Jae-Mok; Chung Sung-Kee; Schultz Peter G
The synthesis and biological characterization of a ceramide library.
Journal of the American Chemical Society 2002;124(9):1856-7.
-
2002: Wang Lei; Brock Ansgar; Schultz Peter G
Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli.
Journal of the American Chemical Society 2002;124(9):1836-7.
-
2002: Watanabe Coran M H; Supekova Lubica; Schultz Peter G
Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin gamma(I)(1).
Chemistry & biology 2002;9(2):245-51.
-
2002: Anderson J Christopher; Magliery Thomas J; Schultz Peter G
Exploring the limits of codon and anticodon size.
Chemistry & biology 2002;9(2):237-44.
-
2002: Ding Sheng; Gray Nathanael S; Wu Xu; Ding Qiang; Schultz Peter G
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
Journal of the American Chemical Society 2002;124(8):1594-6.
-
2002: Wang Lei; Schultz Peter G
Expanding the genetic code.
Chemical communications (Cambridge, England) 2002;(1):1-11.
-
2001: Chang Y T; Wignall S M; Rosania G R; Gray N S; Hanson S R; Su A I; Merlie J; Moon H S; Sangankar S B; Perez O; Heald R; Schultz P G
Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.
Journal of medicinal chemistry 2001;44(26):4497-500.
-
2001: Atwell S; Meggers E; Spraggon G; Schultz P G
Structure of a copper-mediated base pair in DNA.
Journal of the American Chemical Society 2001;123(49):12364-7.
-
2001: Ding S; Gray N S; Ding Q; Schultz P G
A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines.
The Journal of organic chemistry 2001;66(24):8273-6.
-
2001: Wu T Y; Ding S; Gray N S; Schultz P G
Solid-phase synthesis of 2,3,5-trisubstituted indoles.
Organic letters 2001;3(24):3827-30.
-
2001: Lin Q; Jiang F; Schultz P G; Gray N S
Design of allele-specific protein methyltransferase inhibitors.
Journal of the American Chemical Society 2001;123(47):11608-13.
-
2001: Su A I; Welsh J B; Sapinoso L M; Kern S G; Dimitrov P; Lapp H; Schultz P G; Powell S M; Moskaluk C A; Frierson H F; Hampton G M
Molecular classification of human carcinomas by use of gene expression signatures.
Cancer research 2001;61(20):7388-93.
-
2001: Wang L; Schultz P G
A general approach for the generation of orthogonal tRNAs.
Chemistry & biology 2001;8(9):883-90.
-
2001: Pastrnak M; Schultz P G
Phage selection for site-specific incorporation of unnatural amino acids into proteins in vivo.
Bioorganic & medicinal chemistry 2001;9(9):2373-9.
-
2001: Spence M M; Rubin S M; Dimitrov I E; Ruiz E J; Wemmer D E; Pines A; Yao S Q; Tian F; Schultz P G
Functionalized xenon as a biosensor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10654-7.
-
2001: Yin J; Mundorff E C; Yang P L; Wendt K U; Hanway D; Stevens R C; Schultz P G
A comparative analysis of the immunological evolution of antibody 28B4.
Biochemistry 2001;40(36):10764-73.
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2001: Verdugo D E; Cancilla M T; Ge X; Gray N S; Chang Y T; Schultz P G; Negishi M; Leary J A; Bertozzi C R
Discovery of estrogen sulfotransferase inhibitors from a purine library screen.
Journal of medicinal chemistry 2001;44(17):2683-6.
-
2001: Tae E L; Wu Y; Xia G; Schultz P G; Romesberg F E
Efforts toward expansion of the genetic alphabet: replication of DNA with three base pairs.
Journal of the American Chemical Society 2001;123(30):7439-40.
-
2001: Watanabe C M; Wolffram S; Ader P; Rimbach G; Packer L; Maguire J J; Schultz P G; Gohil K
The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6577-80.
-
2001: Grunwell J R; Glass J L; Lacoste T D; Deniz A A; Chemla D S; Schultz P G
Monitoring the conformational fluctuations of DNA hairpins using single-pair fluorescence resonance energy transfer.
Journal of the American Chemical Society 2001;123(18):4295-303.
-
2001: Wang L; Brock A; Herberich B; Schultz P G
Expanding the genetic code of Escherichia coli.
Science (New York, N.Y.) 2001;292(5516):498-500.
-
2001: Magliery T J; Anderson J C; Schultz P G
Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of "shifty" four-base codons with a library approach in Escherichia coli.
Journal of molecular biology 2001;307(3):755-69.
-
2001: Jiang C H; Tsien J Z; Schultz P G; Hu Y
The effects of aging on gene expression in the hypothalamus and cortex of mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1930-4.
-
2001: Deniz A A; Laurence T A; Dahan M; Chemla D S; Schultz P G; Weiss S
Ratiometric single-molecule studies of freely diffusing biomolecules.
Annual review of physical chemistry 2001;52():233-53.
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2000: Rampon C; Jiang C H; Dong H; Tang Y P; Lockhart D J; Schultz P G; Tsien J Z; Hu Y
Effects of environmental enrichment on gene expression in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12880-4.
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2000: Simeonov A; Matsushita M; Juban E A; Thompson E H; Hoffman T Z; Beuscher A E; Taylor M J; Wirsching P; Rettig W; McCusker J K; Stevens R C; Millar D P; Schultz P G; Lerner R A; Janda K D
Blue-fluorescent antibodies.
Science (New York, N.Y.) 2000;290(5490):307-13.
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2000: Bishop A C; Ubersax J A; Petsch D T; Matheos D P; Gray N S; Blethrow J; Shimizu E; Tsien J Z; Schultz P G; Rose M D; Wood J L; Morgan D O; Shokat K M
A chemical switch for inhibitor-sensitive alleles of any protein kinase.
Nature 2000;407(6802):395-401.
-
2000: Berger M; Wu Y; Ogawa A K; McMinn D L; Schultz P G; Romesberg F E
Universal bases for hybridization, replication and chain termination.
Nucleic acids research 2000;28(15):2911-4.
-
2000: Guo Z; Zhou D; Schultz P G
Designing small-molecule switches for protein-protein interactions.
Science (New York, N.Y.) 2000;288(5473):2042-5.
-
2000: Deniz A A; Laurence T A; Beligere G S; Dahan M; Martin A B; Chemla D S; Dawson P E; Schultz P G; Weiss S
Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5179-84.
-
2000: Ly D H; Lockhart D J; Lerner R A; Schultz P G
Mitotic misregulation and human aging.
Science (New York, N.Y.) 2000;287(5462):2486-92.
-
2000: Rosania G R; Chang Y T; Perez O; Sutherlin D; Dong H; Lockhart D J; Schultz P G
Myoseverin, a microtubule-binding molecule with novel cellular effects.
Nature biotechnology 2000;18(3):304-8.
-
2000: Mundorff E C; Hanson M A; Varvak A; Ulrich H; Schultz P G; Stevens R C
Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry 2000;39(4):627-32.
-
1999: Martin A B; Schultz P G
Opportunities at the interface of chemistry and biology.
Trends in cell biology 1999;9(12):M24-8.
-
1999: Yang P L; Schultz P G
Mutational analysis of the affinity maturation of antibody 48G7.
Journal of molecular biology 1999;294(5):1191-201.
-
1999: Chang Y T; Schultz P G
Versatile fluorescence labeling method using activated esters on solid support.
Bioorganic & medicinal chemistry letters 1999;9(17):2479-82.
-
1999: Romesberg F E; Schultz P G
A mutational study of a Diels-Alderase catalytic antibody.
Bioorganic & medicinal chemistry letters 1999;9(13):1741-4.
-
1999: Cho C Y; Liu C W; Wemmer D E; Schultz P G
Cyclic and linear oligocarbamate ligands for human thrombin.
Bioorganic & medicinal chemistry 1999;7(6):1171-9.
-
1999: Yao S; Anex D S; Caldwell W B; Arnold D W; Smith K B; Schultz P G
SDS capillary gel electrophoresis of proteins in microfabricated channels.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5372-7.
-
1999: Rosania G R; Merlie J; Gray N; Chang Y T; Schultz P G; Heald R
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):4797-802.
-
1999: Liu D R; Schultz P G
Progress toward the evolution of an organism with an expanded genetic code.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):4780-5.
-
1999: Deniz A A; Dahan M; Grunwell J R; Ha T; Faulhaber A E; Chemla D S; Weiss S; Schultz P G
Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Förster distance dependence and subpopulations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3670-5.
-
1999: Ha T; Ting A Y; Liang J; Caldwell W B; Deniz A A; Chemla D S; Schultz P G; Weiss S
Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):893-8.
-
1998: Romesberg F E; Santarsiero B D; Spiller B; Yin J; Barnes D; Schultz P G; Stevens R C
Structural and kinetic evidence for strain in biological catalysis.
Biochemistry 1998;37(41):14404-9.
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1998: Pedersen H; Hölder S; Sutherlin D P; Schwitter U; King D S; Schultz P G
A method for directed evolution and functional cloning of enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10523-8.
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1998: Gray N S; Wodicka L; Thunnissen A M; Norman T C; Kwon S; Espinoza F H; Morgan D O; Barnes G; LeClerc S; Meijer L; Kim S H; Lockhart D J; Schultz P G
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science (New York, N.Y.) 1998;281(5376):533-8.
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1998: Ma L; Hsieh-Wilson L C; Schultz P G
Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7251-6.
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1998: Romesberg F E; Spiller B; Schultz P G; Stevens R C
Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science (New York, N.Y.) 1998;279(5358):1929-33.
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1998: Yu J; Choi S Y; Moon K D; Chung H H; Youn H J; Jeong S; Park H; Schultz P G
A glycosidase antibody elicited against a chair-like transition state analog by in vitro immunization.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2880-4.
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1998: Blackwood M E; Rush T S; Romesberg F; Schultz P G; Spiro T G
Alternative modes of substrate distortion in enzyme and antibody catalyzed ferrochelation reactions.
Biochemistry 1998;37(3):779-82.
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1998: Ulrich H D; Schultz P G
Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies.
Journal of molecular biology 1998;275(1):95-111.
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1998: Thorson J S; Cornish V W; Barrett J E; Cload S T; Yano T; Schultz P G
A biosynthetic approach for the incorporation of unnatural amino acids into proteins.
Methods in molecular biology (Clifton, N.J.) 1998;77():43-73.
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1997: Liu D R; Magliery T J; Schultz P G
Characterization of an 'orthogonal' suppressor tRNA derived from E. coli tRNA2(Gln).
Chemistry & biology 1997;4(9):685-91.
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1997: Ulrich H D; Mundorff E; Santarsiero B D; Driggers E M; Stevens R C; Schultz P G
The interplay between binding energy and catalysis in the evolution of a catalytic antibody.
Nature 1997;389(6648):271-5.
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1997: Koh J T; Cornish V W; Schultz P G
An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis.
Biochemistry 1997;36(38):11314-22.
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1997: Liu D R; Magliery T J; Pastrnak M; Schultz P G
Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10092-7.
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1997: Park Y; Luo J; Schultz P G; Kirsch J F
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism.
Biochemistry 1997;36(34):10517-25.
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1997: Wedemayer G J; Patten P A; Wang L H; Schultz P G; Stevens R C
Structural insights into the evolution of an antibody combining site.
Science (New York, N.Y.) 1997;276(5319):1665-9.
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1997: Wedemayer G J; Wang L H; Patten P A; Schultz P G; Stevens R C
Crystal structures of the free and liganded form of an esterolytic catalytic antibody.
Journal of molecular biology 1997;268(2):390-400.
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1997: Johnsson K; Froland W A; Schultz P G
Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis.
The Journal of biological chemistry 1997;272(5):2834-40.
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1997: Ulrich H D; Moore F L; Schultz P G
Germline diversity within the mouse Igk-V9 gene family.
Immunogenetics 1997;47(1):91-5.
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1996: Cload S T; Liu D R; Froland W A; Schultz P G
Development of improved tRNAs for in vitro biosynthesis of proteins containing unnatural amino acids.
Chemistry & biology 1996;3(12):1033-8.
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1996: Alivisatos A P; Johnsson K P; Peng X; Wilson T E; Loweth C J; Bruchez M P; Schultz P G
Organization of 'nanocrystal molecules' using DNA.
Nature 1996;382(6592):609-11.
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1996: Hsieh-Wilson L C; Schultz P G; Stevens R C
Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5363-7.
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1996: Ulrich H D; Driggers E M; Schultz P G
Antibody catalysis of pericyclic reactions.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1996;50(4):328-32.
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1996: Sera T; Schultz P G
In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2920-5.
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1996: Patten P A; Gray N S; Yang P L; Marks C B; Wedemayer G J; Boniface J J; Stevens R C; Schultz P G
The immunological evolution of catalysis.
Science (New York, N.Y.) 1996;271(5252):1086-91.
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1996: Driggers E M; Schultz P G
Catalytic antibodies.
Advances in protein chemistry 1996;49():261-87.
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1995: Ulrich H D; Patten P A; Yang P L; Romesberg F E; Schultz P G
Expression studies of catalytic antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11907-11.
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1995: Schultz P G; Lerner R A
From molecular diversity to catalysis: lessons from the immune system.
Science (New York, N.Y.) 1995;269(5232):1835-42.
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1995: Ku J; Schultz P G
Alternate protein frameworks for molecular recognition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6552-6.
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1995: Moran E J; Wilson T E; Cho C Y; Cherry S R; Schultz P G
Novel biopolymers for drug discovery.
Biopolymers 1995;37(3):213-9.
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1995: Mendel D; Cornish V W; Schultz P G
Site-directed mutagenesis with an expanded genetic code.
Annual review of biophysics and biomolecular structure 1995;24():435-62.
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1994: Ku J; Schultz P G
Phage display of catalytically active staphylococcal nuclease.
Bioorganic & medicinal chemistry 1994;2(12):1413-5.
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1994: Cornish V W; Kaplan M I; Veenstra D L; Kollman P A; Schultz P G
Stabilizing and destabilizing effects of placing beta-branched amino acids in protein alpha-helices.
Biochemistry 1994;33(40):12022-31.
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1994: Jacobsen J R; Schultz P G
Antibody catalysis of peptide bond formation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5888-92.
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1994: Prudent J R; Uno T; Schultz P G
Expanding the scope of RNA catalysis.
Science (New York, N.Y.) 1994;264(5167):1924-7.
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1994: Huang L; Sera T; Schultz P G
A permutational approach toward protein-DNA recognition.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3969-73.
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1994: Cornish V W; Benson D R; Altenbach C A; Hideg K; Hubbell W L; Schultz P G
Site-specific incorporation of biophysical probes into proteins.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):2910-4.
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1993: Chung H H; Benson D R; Cornish V W; Schultz P G
Probing the role of loop 2 in Ras function with unnatural amino acids.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10145-9.
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1993: Angeles T S; Smith R G; Darsley M J; Sugasawara R; Sanchez R I; Kenten J; Schultz P G; Martin M T
Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization.
Biochemistry 1993;32(45):12128-35.
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1993: Judice J K; Gamble T R; Murphy E C; de Vos A M; Schultz P G
Probing the mechanism of staphylococcal nuclease with unnatural amino acids: kinetic and structural studies.
Science (New York, N.Y.) 1993;261(5128):1578-81.
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1993: Cho C Y; Moran E J; Cherry S R; Stephans J C; Fodor S P; Adams C L; Sundaram A; Jacobs J W; Schultz P G
An unnatural biopolymer.
Science (New York, N.Y.) 1993;261(5126):1303-5.
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1993: Hsieh L C; Yonkovich S; Kochersperger L; Schultz P G
Controlling chemical reactivity with antibodies.
Science (New York, N.Y.) 1993;260(5106):337-9.
-
1993: Chung H H; Benson D R; Schultz P G
Probing the structure and mechanism of Ras protein with an expanded genetic code.
Science (New York, N.Y.) 1993;259(5096):806-9.
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1993: Lesley S A; Patten P A; Schultz P G
A genetic approach to the generation of antibodies with enhanced catalytic activities.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1160-5.
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1992: Mendel D; Ellman J A; Chang Z; Veenstra D L; Kollman P A; Schultz P G
Probing protein stability with unnatural amino acids.
Science (New York, N.Y.) 1992;256(5065):1798-802.
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1992: Jacobsen J R; Prudent J R; Kochersperger L; Yonkovich S; Schultz P G
An efficient antibody-catalyzed aminoacylation reaction.
Science (New York, N.Y.) 1992;256(5055):365-7.
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1992: Ellman J A; Mendel D; Schultz P G
Site-specific incorporation of novel backbone structures into proteins.
Science (New York, N.Y.) 1992;255(5041):197-200.
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1991: Martin M T; Napper A D; Schultz P G; Rees A R
Mechanistic studies of a tyrosine-dependent catalytic antibody.
Biochemistry 1991;30(40):9757-61.
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1991: Pei D H; Ulrich H D; Schultz P G
A combinatorial approach toward DNA recognition.
Science (New York, N.Y.) 1991;253(5026):1408-11.
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1991: Scanlon T S; Schultz P G
Recent advances in catalytic antibodies.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1991;332(1263):157-64.
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1991: Jackson D Y; Prudent J R; Baldwin E P; Schultz P G
A mutagenesis study of a catalytic antibody.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):58-62.
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1991: Nakayama G R; Schultz P G
Approaches to the design of semisynthetic metal-dependent catalytic antibodies.
Ciba Foundation symposium 1991;159():72-81; discussion 81-90.
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1991: Shokat K M; Schultz P G
The generation of antibody combining sites containing catalytic residues.
Ciba Foundation symposium 1991;159():118-28; discussion 128-34.
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1991: Ellman J; Mendel D; Anthony-Cahill S; Noren C J; Schultz P G
Biosynthetic method for introducing unnatural amino acids site-specifically into proteins.
Methods in enzymology 1991;202():301-36.
-
1991: Shokat K M; Schultz P G
Catalytic antibodies.
Methods in enzymology 1991;203():327-51.
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1990: Pei D; Corey D R; Schultz P G
Site-specific cleavage of duplex DNA by a semisynthetic nuclease via triple-helix formation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9858-62.
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1990: Cochran A G; Schultz P G
Antibody-catalyzed porphyrin metallation.
Science (New York, N.Y.) 1990;249(4970):781-3.
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1990: Noren C J; Anthony-Cahill S J; Suich D J; Noren K A; Griffith M C; Schultz P G
In vitro suppression of an amber mutation by a chemically aminoacylated transfer RNA prepared by runoff transcription.
Nucleic acids research 1990;18(1):83-8.
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1990: Shokat K M; Schultz P G
Catalytic antibodies.
Annual review of immunology 1990;8():335-63.
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1989: Robertson S A; Noren C J; Anthony-Cahill S J; Griffith M C; Schultz P G
The use of 5'-phospho-2 deoxyribocytidylylriboadenosine as a facile route to chemical aminoacylation of tRNA.
Nucleic acids research 1989;17(23):9649-60.
-
1989: Anthony-Cahill S J; Griffith M C; Noren C J; Suich D J; Schultz P G
Site-specific mutagenesis with unnatural amino acids.
Trends in biochemical sciences 1989;14(10):400-3.
-
1989: Corey D R; Pei D; Schultz P G
Generation of a catalytic sequence-specific hybrid DNase.
Biochemistry 1989;28(21):8277-86.
-
1989: Baldwin E; Schultz P G
Generation of a catalytic antibody by site-directed mutagenesis.
Science (New York, N.Y.) 1989;245(4922):1104-7.
-
1989: Noren C J; Anthony-Cahill S J; Griffith M C; Schultz P G
A general method for site-specific incorporation of unnatural amino acids into proteins.
Science (New York, N.Y.) 1989;244(4901):182-8.
-
1989: Shokat K M; Leumann C J; Sugasawara R; Schultz P G
A new strategy for the generation of catalytic antibodies.
Nature 1989;338(6212):269-71.
-
1989: Corey D R; Schultz P G
Introduction of a metal-dependent regulatory switch into an enzyme.
The Journal of biological chemistry 1989;264(7):3666-9.
-
1989: Zuckermann R N; Schultz P G
Site-selective cleavage of structured RNA by a staphylococcal nuclease-DNA hybrid.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):1766-70.
-
1989: Pollack S J; Nakayama G R; Schultz P G
Design of catalytic antibodies.
Methods in enzymology 1989;178():551-68.
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1988: Pollack S J; Nakayama G R; Schultz P G
Introduction of nucleophiles and spectroscopic probes into antibody combining sites.
Science (New York, N.Y.) 1988;242(4881):1038-40.
-
1988: Schultz P G
The interplay between chemistry and biology in the design of enzymatic catalysts.
Science (New York, N.Y.) 1988;240(4851):426-33.
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1987: Corey D R; Schultz P G
Generation of a hybrid sequence-specific single-stranded deoxyribonuclease.
Science (New York, N.Y.) 1987;238(4832):1401-3.
-
1987: Pollack S J; Schultz P G
Antibody catalysis by transition state stabilization.
Cold Spring Harbor symposia on quantitative biology 1987;52():97-104.
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1986: Pollack S J; Jacobs J W; Schultz P G
Selective chemical catalysis by an antibody.
Science (New York, N.Y.) 1986;234(4783):1570-3.
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