Klaus Schulze-Osthoff

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Dalla Rosa Ilaria; Goffart Steffi; Wurm Melanie; Wiek Constanze; Essmann Frank; Sobek Stefan; Schroeder Peter; Zhang Hongliang; Krutmann Jean; Hanenberg Helmut; Schulze-Osthoff Klaus; Mielke Christian; Pommier Yves; Boege Fritz; Christensen Morten O
Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.
Bantel Heike; Bahr Matthias J; Schulze-Osthoff Klaus
An apoptosis biomarker for prediction of nonalcoholic steatohepatitis.
Los Marek; Panigrahi Soumya; Rashedi Iran; Mandal Sanat; Stetefeld Joerg; Essmann Frank; Schulze-Osthoff Klaus
Apoptin, a tumor-selective killer.

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All Publications

2009: Dalla Rosa Ilaria; Goffart Steffi; Wurm Melanie; Wiek Constanze; Essmann Frank; Sobek Stefan; Schroeder Peter; Zhang Hongliang; Krutmann Jean; Hanenberg Helmut; Schulze-Osthoff Klaus; Mielke Christian; Pommier Yves; Boege Fritz; Christensen Morten O
Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.
Nucleic acids research 2009;37(19):6414-28.
2009: Bantel Heike; Bahr Matthias J; Schulze-Osthoff Klaus
An apoptosis biomarker for prediction of nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2009;50(3):991.
2009: Los Marek; Panigrahi Soumya; Rashedi Iran; Mandal Sanat; Stetefeld Joerg; Essmann Frank; Schulze-Osthoff Klaus
Apoptin, a tumor-selective killer.
Biochimica et biophysica acta 2009;1793(8):1335-42.
2009: Los Marek; Schulze-Osthoff Klaus
Catching chromatin relaxation in act by flow cytometry.
Cell cycle (Georgetown, Tex.) 2009;8(14):2140-1.
2009: Lindenblatt Charlotte; Schulze-Osthoff Klaus; Totzke Gudrun
IkappaBzeta expression is regulated by miR-124a.
Cell cycle (Georgetown, Tex.) 2009;8(13):2019-23.
2009: Hofer Stefan; Rosenhagen Claudia; Nakamura Hajime; Yodoi Junji; Bopp Christian; Zimmermann Johannes B; Goebel Meike; Schemmer Peter; Hoffmann Kartrin; Schulze-Osthoff Klaus; Breitkreutz Raoul; Weigand Markus A
Thioredoxin in human and experimental sepsis.
Critical care medicine 2009;37(7):2155-9.
2009: Ueffing Nana; Singh Kusum K; Christians Andrea; Thorns Christoph; Feller Alfred C; Nagl Florian; Fend Falko; Heikaus Sebastian; Marx Alexander; Zotz Rainer B; Brade Joachim; Schulz Wolfgang A; Schulze-Osthoff Klaus; Schmitz Ingo; Schwerk Christian
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein.
Blood 2009;114(3):572-9.
2009: Sohn D; Graupner V; Neise D; Essmann F; Schulze-Osthoff K; Jänicke R U
Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.
Cell death and differentiation 2009;16(6):869-78.
2009: Los Marek; Maddika Subbareddy; Erb Bettina; Schulze-Osthoff Klaus
Switching Akt: from survival signaling to deadly response.
BioEssays : news and reviews in molecular, cellular and developmental biology 2009;31(5):492-5.
2009: Graupner Vilma; Schulze-Osthoff Klaus; Essmann Frank; Jänicke Reiner U
Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53.
Cell cycle (Georgetown, Tex.) 2009;8(8):1238-48.
2009: Maddika Subbareddy; Panigrahi Soumya; Wiechec Emilia; Wesselborg Sebastian; Fischer Ute; Schulze-Osthoff Klaus; Los Marek
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Molecular and cellular biology 2009;29(5):1235-48.
2009: Bantel Heike; Schulze-Osthoff Klaus
Cell death in sepsis: a matter of how, when, and where.
Critical care (London, England) 2009;13(4):173.
2008: Rudy A; López-Antón N; Barth N; Pettit G R; Dirsch V M; Schulze-Osthoff K; Rehm M; Prehn J H M; Vogler M; Fulda S; Vollmar A M
Role of Smac in cephalostatin-induced cell death.
Cell death and differentiation 2008;15(12):1930-40.
2008: Hombach-Klonisch Sabine; Panigrahi Soumya; Rashedi Iran; Seifert Anja; Alberti Esteban; Pocar Paola; Kurpisz Maciej; Schulze-Osthoff Klaus; Mackiewicz Andrzej; Los Marek
Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications.
Journal of molecular medicine (Berlin, Germany) 2008;86(12):1301-14.
2008: Klonisch Thomas; Wiechec Emilia; Hombach-Klonisch Sabine; Ande Sudharsana R; Wesselborg Sebastian; Schulze-Osthoff Klaus; Los Marek
Cancer stem cell markers in common cancers - therapeutic implications.
Trends in molecular medicine 2008;14(10):450-60.
2008: Ueffing Nana; Schuster Marc; Keil Eric; Schulze-Osthoff Klaus; Schmitz Ingo
Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells.
Blood 2008;112(3):690-8.
2008: Stampfuss Jan-Julius; Censarek Petra; Fischer Jens W; Kaber Gernot; Rauch Bernhard H; Freidel Kerstin; Fischer Ute; Schulze-Osthoff Klaus; Grosser Tilo; Grandoch Maria; Schrör Karsten; Weber Artur-Aron
Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1375-8.
2008: Hassan M; Alaoui A; Feyen O; Mirmohammadsadegh A; Essmann F; Tannapfel A; Gulbins E; Schulze-Osthoff K; Hengge U R
The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways.
Oncogene 2008;27(33):4557-68.
2008: Jänicke R U; Sohn D; Schulze-Osthoff K
The dark side of a tumor suppressor: anti-apoptotic p53.
Cell death and differentiation 2008;15(6):959-76.
2008: Hombach-Klonisch Sabine; Paranjothy Ted; Wiechec Emilia; Pocar Paola; Mustafa Tarek; Seifert Anja; Zahl Christian; Gerlach Klaus Luis; Biermann Katharina; Steger Klaus; Hoang-Vu Cuong; Schulze-Osthoff Klaus; Los Marek
Cancer stem cells as targets for cancer therapy: selected cancers as examples.
Archivum immunologiae et therapiae experimentalis 2008;56(3):165-80.
2008: Volkmann Xandra; Anstaett Matthias; Hadem Johannes; Stiefel Penelope; Bahr Matthias J; Lehner Frank; Manns Michael P; Schulze-Osthoff Klaus; Bantel Heike
Caspase activation is associated with spontaneous recovery from acute liver failure.
Hepatology (Baltimore, Md.) 2008;47(5):1624-33.
2008: Maddika S; Wiechec E; Ande S R; Poon I K; Fischer U; Wesselborg S; Jans D A; Schulze-Osthoff K; Los M
Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin.
Oncogene 2008;27(21):3060-5.
2008: Ueffing N; Keil E; Freund C; Kühne R; Schulze-Osthoff K; Schmitz I
Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment.
Cell death and differentiation 2008;15(4):773-82.
2008: Peter Christoph; Waibel Michaela; Radu Caius G; Yang Li V; Witte Owen N; Schulze-Osthoff Klaus; Wesselborg Sebastian; Lauber Kirsten
Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
The Journal of biological chemistry 2008;283(9):5296-305.
2008: Ghavami Saeid; Kerkhoff Claus; Chazin Walter J; Kadkhoda Kamran; Xiao Wenyan; Zuse Anne; Hashemi Mohammad; Eshraghi Mehdi; Schulze-Osthoff Klaus; Klonisch Thomas; Los Marek
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
Biochimica et biophysica acta 2008;1783(2):297-311.
2008: Neise D; Graupner V; Gillissen B F; Daniel P T; Schulze-Osthoff K; Jänicke R U; Essmann F
Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak.
Oncogene 2008;27(10):1387-96.
2008: Knobloch Jürgen; Schmitz Ingo; Götz Katrin; Schulze-Osthoff Klaus; Rüther Ulrich
Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death.
Molecular and cellular biology 2008;28(2):529-38.
2008: Tretiakova Irina; Blaesius Dagmar; Maxia Lucia; Wesselborg Sebastian; Schulze-Osthoff Klaus; Cinatl Jindrich; Michaelis Martin; Werz Oliver
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9.
Apoptosis : an international journal on programmed cell death 2008;13(1):119-31.
2008: Schneider L; Essmann F; Kletke A; Rio P; Hanenberg H; Schulze-Osthoff K; Nürnberg B; Piekorz R P
TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest.
Oncogene 2008;27(1):116-25.
2007: Fischer Ute; Janssen Katja; Schulze-Osthoff Klaus
Does caspase inhibition promote clonogenic tumor growth?
Cell cycle (Georgetown, Tex.) 2007;6(24):3048-53.
2007: Volkmann Xandra; Fischer Ute; Bahr Matthias J; Ott Michael; Lehner Frank; Macfarlane Marion; Cohen Gerald M; Manns Michael P; Schulze-Osthoff Klaus; Bantel Heike
Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver.
Hepatology (Baltimore, Md.) 2007;46(5):1498-508.
2007: Janssen Katja; Pohlmann Stephan; Jänicke Reiner U; Schulze-Osthoff Klaus; Fischer Ute
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment.
Blood 2007;110(10):3662-72.
2007: Schulze-Osthoff Klaus; Häussinger Dieter
Apoptosis in the liver: a matter of ion fluxes and oxidative stress: Third International Conference of the Collaborative Research Center 'Experimental Hepatology' (SFB-575), Düsseldorf, Germany, 13-14 October 2006.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(8):1039-44.
2007: Schneider Leonid; Essmann Frank; Kletke Anja; Rio Paula; Hanenberg Helmut; Wetzel Wiebke; Schulze-Osthoff Klaus; Nürnberg Bernd; Piekorz Roland P
The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.
The Journal of biological chemistry 2007;282(40):29273-83.
2007: Werdehausen Robert; Braun Sebastian; Essmann Frank; Schulze-Osthoff Klaus; Walczak Henning; Lipfert Peter; Stevens Markus F
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
Anesthesiology 2007;107(1):136-43.
2007: Troeger Anja; Schmitz Ingo; Siepermann Meinolf; Glouchkova Ludmila; Gerdemann Ulrike; Janka-Schaub Gritta E; Schulze-Osthoff Klaus; Dilloo Dagmar
Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL.
Blood 2007;110(1):384-7.
2007: Vutova Polya; Wirth Martina; Hippe Diana; Gross Uwe; Schulze-Osthoff Klaus; Schmitz Ingo; Lüder Carsten G K
Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8.
Cellular microbiology 2007;9(6):1556-70.
2007: Waibel Michaela; Kramer Stefan; Lauber Kirsten; Lupescu Adrian; Manns Joachim; Schulze-Osthoff Klaus; Lang Florian; Wesselborg Sebastian
Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis.
Apoptosis : an international journal on programmed cell death 2007;12(3):623-30.
2007: Viemann Dorothee; Barczyk Katarzyna; Vogl Thomas; Fischer Ute; Sunderkötter Cord; Schulze-Osthoff Klaus; Roth Johannes
MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program.
Blood 2007;109(6):2453-60.
2007: Janssen K; Hofmann T G; Jans D A; Hay R T; Schulze-Osthoff K; Fischer U
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.
Oncogene 2007;26(11):1557-66.
2007: Jänicke Reiner U; Sohn Dennis; Essmann Frank; Schulze-Osthoff Klaus
The multiple battles fought by anti-apoptotic p21.
Cell cycle (Georgetown, Tex.) 2007;6(4):407-13.
2007: Samraj Ajoy K; Sohn Dennis; Schulze-Osthoff Klaus; Schmitz Ingo
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization.
Molecular biology of the cell 2007;18(1):84-93.
2007: Fischer Ute; Janssen Katja; Schulze-Osthoff Klaus
Cutting-edge apoptosis-based therapeutics: a panacea for cancer?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2007;21(5):273-97.
2006: Sohn Dennis; Essmann Frank; Schulze-Osthoff Klaus; Jänicke Reiner U
p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation.
Cancer research 2006;66(23):11254-62.
2006: Schmitz I; Meyer C; Schulze-Osthoff K
CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma.
Oncogene 2006;25(58):7587-96.
2006: López-Antón Nancy; Rudy Anita; Barth Nicole; Schmitz M Lienhard; Pettit George R; Schulze-Osthoff Klaus; Dirsch Verena M; Vollmar Angelika M
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway.
The Journal of biological chemistry 2006;281(44):33078-86.
2006: Samraj Ajoy K; Keil Eric; Ueffing Nana; Schulze-Osthoff Klaus; Schmitz Ingo
Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis.
The Journal of biological chemistry 2006;281(40):29652-9.
2006: Berg Christoph P; Stein Gerburg M; Klein Reinhild; Pascu Maria; Berg Thomas; Kammer Winfried; Priemer Martin; Nordheim Alfred; Schulze-Osthoff Klaus; Gregor Michael; Wesselborg Sebastian; Berg Peter A
Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(7):846-55.
2006: Haslinger-Löffler B; Wagner B; Brück M; Strangfeld K; Grundmeier M; Fischer U; Völker W; Peters G; Schulze-Osthoff K; Sinha B
Staphylococcus aureus induces caspase-independent cell death in human peritoneal mesothelial cells.
Kidney international 2006;70(6):1089-98.
2006: Jänicke Reiner U; Sohn Dennis; Totzke Gudrun; Schulze-Osthoff Klaus
Caspase-10 in mouse or not?
Science (New York, N.Y.) 2006;312(5782):1874.
2006: Volkmann Xandra; Cornberg Markus; Wedemeyer Heiner; Lehner Frank; Manns Michael P; Schulze-Osthoff Klaus; Bantel Heike
Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2006;43(6):1311-6.
2006: Stoldt Volker R; Schnorr Oliver; Schulze-Osthoff Klaus; Scharf Rudiger E
Transforming growth factor-beta1 enhances the antifibrinolytic and prothrombotic state of growing endothelial cells in a cell cycle-specific manner.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):965-6.
2006: Joselin Alvin P; Schulze-Osthoff Klaus; Schwerk Christian
Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis.
The Journal of biological chemistry 2006;281(18):12475-84.
2006: Totzke Gudrun; Essmann Frank; Pohlmann Stephan; Lindenblatt Charlotte; Jänicke Reiner U; Schulze-Osthoff Klaus
A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.
The Journal of biological chemistry 2006;281(18):12645-54.
2006: Sohn Dennis; Totzke Gudrun; Schulze-Osthoff Klaus; Jänicke Reiner U
Friend or foe? The proteasome in combined cancer therapy.
Cell cycle (Georgetown, Tex.) 2006;5(8):841-5.
2006: Zacharowski Kai; Zacharowski Paula A; Koch Alexander; Baban Aida; Tran Nguyen; Berkels Reinhard; Papewalis Claudia; Schulze-Osthoff Klaus; Knuefermann Pascal; Zähringer Ulrich; Schumann Ralf R; Rettori Valeria; McCann Samuel M; Bornstein Stefan R
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6392-7.
2006: Wolf Sabine C; Schultze Michael; Risler Teut; Rieg Timo; Lang Florian; Schulze-Osthoff Klaus; Brehm Bernhard R
Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1.
Biochemical pharmacology 2006;71(8):1175-83.
2006: Burek M; Maddika S; Burek C J; Daniel P T; Schulze-Osthoff K; Los M
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.
Oncogene 2006;25(15):2213-22.
2006: Sohn Dennis; Totzke Gudrun; Essmann Frank; Schulze-Osthoff Klaus; Levkau Bodo; Jänicke Reiner U
The proteasome is required for rapid initiation of death receptor-induced apoptosis.
Molecular and cellular biology 2006;26(5):1967-78.
2006: Wendt J; Radetzki S; von Haefen C; Hemmati P G; Güner D; Schulze-Osthoff K; Dörken B; Daniel P T
Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.
Oncogene 2006;25(7):972-80.
2006: Fischer U; Stroh C; Schulze-Osthoff K
Unique and overlapping substrate specificities of caspase-8 and caspase-10.
Oncogene 2006;25(1):152-9.
2006: Samraj A K; Stroh C; Fischer U; Schulze-Osthoff K
The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression.
Oncogene 2006;25(2):186-97.
2005: Viemann Dorothee; Schulze-Osthoff Klaus; Roth Johannes
Potentials and pitfalls of DNA array analysis of the endothelial stress response.
Biochimica et biophysica acta 2005;1746(2):73-84.
2005: Essmann Frank; Pohlmann Stephan; Gillissen Bernhard; Daniel Peter T; Schulze-Osthoff Klaus; Jänicke Reiner U
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis.
The Journal of biological chemistry 2005;280(44):37169-77.
2005: Bantel Heike; Beikler Thomas; Flemmig Thomas F; Schulze-Osthoff Klaus
Caspase activation is involved in chronic periodontitis.
FEBS letters 2005;579(25):5559-64.
2005: Schwerk Christian; Schulze-Osthoff Klaus
Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death.
Oncogene 2005;24(47):7002-11.
2005: Scholz Christian; Richter Antje; Lehmann Mario; Schulze-Osthoff Klaus; Dörken Bernd; Daniel Peter T
Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway.
Oncogene 2005;24(47):7031-42.
2005: Siegmund Daniela; Wicovsky Andreas; Schmitz Ingo; Schulze-Osthoff Klaus; Kreuz Sebastian; Leverkus Martin; Dittrich-Breiholz Oliver; Kracht Michael; Wajant Harald
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing.
Molecular and cellular biology 2005;25(15):6363-79.
2005: Haslinger-Löffler Bettina; Kahl Barbara C; Grundmeier Matthias; Strangfeld Katrin; Wagner Britta; Fischer Ute; Cheung Ambrose L; Peters Georg; Schulze-Osthoff Klaus; Sinha Bhanu
Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells.
Cellular microbiology 2005;7(8):1087-97.
2005: Fischer U; Schulze-Osthoff K
Apoptosis-based therapies and drug targets.
Cell death and differentiation 2005;12 Suppl 1():942-61.
2005: Schwerk Christian; Schulze-Osthoff Klaus
Regulation of apoptosis by alternative pre-mRNA splicing.
Molecular cell 2005;19(1):1-13.
2005: Seidel Nicole; Volkmann Xandra; Länger Florian; Flemming Peer; Manns Michael P; Schulze-Osthoff Klaus; Bantel Heike
The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum.
Hepatology (Baltimore, Md.) 2005;42(1):113-20.
2005: Fischer Ute; Schulze-Osthoff Klaus
New approaches and therapeutics targeting apoptosis in disease.
Pharmacological reviews 2005;57(2):187-215.
2005: Engels Ingo H; Totzke Gudrun; Fischer Ute; Schulze-Osthoff Klaus; Jänicke Reiner U
Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner.
Molecular and cellular biology 2005;25(7):2808-18.
2005: Scholz Christian; Wieder Thomas; Stärck Lilian; Essmann Frank; Schulze-Osthoff Klaus; Dörken Bernd; Daniel Peter T
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway.
Oncogene 2005;24(11):1904-13.
2005: Sohn Dennis; Schulze-Osthoff Klaus; Jänicke Reiner U
Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis.
The Journal of biological chemistry 2005;280(7):5267-73.
2005: Fischer Ute; Steffens Sabine; Frank Susanne; Rainov Nikolai G; Schulze-Osthoff Klaus; Kramm Christof M
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.
Oncogene 2005;24(7):1231-43.
2005: Buddenkotte Jörg; Stroh Christopher; Engels Ingo H; Moormann Corinna; Shpacovitch Victoria M; Seeliger Stephan; Vergnolle Nathalie; Vestweber Dietmar; Luger Thomas A; Schulze-Osthoff Klaus; Steinhoff Martin
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
The Journal of investigative dermatology 2005;124(1):38-45.
2004: Klöpfer Antje; Hasenjäger Anne; Belka Claus; Schulze-Osthoff Klaus; Dörken Bernd; Daniel Peter T
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway.
Oncogene 2004;23(58):9408-18.
2004: Bornstein Stefan R; Zacharowski Paula; Schumann Ralf R; Barthel Andreas; Tran Nguyen; Papewalis Claudia; Rettori Valeria; McCann Samuel M; Schulze-Osthoff Klaus; Scherbaum Werner A; Tarnow Jörg; Zacharowski Kai
Impaired adrenal stress response in Toll-like receptor 2-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16695-700.
2004: Bantel Heike; Lügering Andreas; Heidemann Jan; Volkmann Xandra; Poremba Christopher; Strassburg Christian P; Manns Michael Peter; Schulze-Osthoff Klaus
Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury.
Hepatology (Baltimore, Md.) 2004;40(5):1078-87.
2004: Essmann Frank; Engels Ingo H; Totzke Gudrun; Schulze-Osthoff Klaus; Jänicke Reiner U
Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event.
Cancer research 2004;64(19):7065-72.
2004: Schmelz Karin; Wieder Thomas; Tamm Ingo; Müller Antje; Essmann Frank; Geilen Christoph-C; Schulze-Osthoff Klaus; Dörken Bernd; Daniel Peter-T
Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.
Oncogene 2004;23(40):6743-59.
2004: Müller F U; Loser K; Kleideiter U; Neumann J; von Wallbrunn C; Dobner T; Scheld H-H; Bantel H; Engels I H; Schulze-Osthoff K; Schmitz W
Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes.
Cell death and differentiation 2004;11(5):485-93.
2004: Pandiyan Pushpa; Gärtner Dagmar; Soezeri Osman; Radbruch Andreas; Schulze-Osthoff Klaus; Brunner-Weinzierl Monika C
CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.
The Journal of experimental medicine 2004;199(6):831-42.
2003: Krilleke Dominik; Ucur Esat; Pulte Dianne; Schulze-Osthoff Klaus; Debatin Klaus-Michael; Herr Ingrid
Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis.
International journal of cancer. Journal international du cancer 2003;107(4):520-7.
2003: Essmann F; Bantel H; Totzke G; Engels I H; Sinha B; Schulze-Osthoff K; Jänicke R U
Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation.
Cell death and differentiation 2003;10(11):1260-72.
2003: Schwerk Christian; Schulze-Osthoff Klaus
Non-apoptotic functions of caspases in cellular proliferation and differentiation.
Biochemical pharmacology 2003;66(8):1453-8.
2003: Haslinger Bettina; Strangfeld Katrin; Peters Georg; Schulze-Osthoff Klaus; Sinha Bhanu
Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway.
Cellular microbiology 2003;5(10):729-41.
2003: Totzke Gudrun; Schulze-Osthoff Klaus; Jänicke Reiner U
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.
Oncogene 2003;22(39):8021-30.
2003: Stroh Christopher; Held Jürgen; Samraj Ajoy Kumar; Schulze-Osthoff Klaus
Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22.
Oncogene 2003;22(34):5367-73.
2003: Gillissen Bernhard; Essmann Frank; Graupner Vilma; Stärck Lilian; Radetzki Silke; Dörken Bernd; Schulze-Osthoff Klaus; Daniel Peter T
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
The EMBO journal 2003;22(14):3580-90.
2003: Lauber Kirsten; Bohn Erwin; Kröber Stefan Martin; Xiao Yi-jin; Blumenthal Sibylle G; Lindemann Ralph K; Marini Patrizia; Wiedig Carolin; Zobywalski Anke; Baksh Shairaz; Xu Yan; Autenrieth Ingo B; Schulze-Osthoff Klaus; Belka Claus; Stuhler Gernot; Wesselborg Sebastian
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
Cell 2003;113(6):717-30.
2003: Schlosser Stephan F; Schuler Markus; Berg Christoph P; Lauber Kirsten; Schulze-Osthoff Klaus; Schmahl Friedrich Wilhelm; Wesselborg Sebastian
Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells.
Antimicrobial agents and chemotherapy 2003;47(6):1912-21.
2003: von Haefen Clarissa; Wieder Thomas; Essmann Frank; Schulze-Osthoff Klaus; Dörken Bernd; Daniel Peter T
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop.
Oncogene 2003;22(15):2236-47.
2003: Zeller Martin; Essmann Frank; Jänicke Reiner U; Schulze-Osthoff Klaus; König Simone
A rapid nonradioactive peptide phosphorylation assay.
Journal of experimental therapeutics & oncology 2003;3(2):59-61.
2003: Berg Christoph P; Rothbart Andreas; Lauber Kirsten; Stein Gerburg M; Engels Ingo H; Belka Claus; Jänicke Reiner U; Schulze-Osthoff Klaus; Wesselborg Sebastian
Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets.
Oncogene 2003;22(5):775-80.
2003: Bantel H; Schulze-Osthoff K
Apoptosis in hepatitis C virus infection.
Cell death and differentiation 2003;10 Suppl 1():S48-58.
2003: Fischer U; Jänicke R U; Schulze-Osthoff K
Many cuts to ruin: a comprehensive update of caspase substrates.
Cell death and differentiation 2003;10(1):76-100.
2003: Daniel Peter T; Schulze-Osthoff Klaus; Belka Claus; Güner Dilek
Guardians of cell death: the Bcl-2 family proteins.
Essays in biochemistry 2003;39():73-88.
2002: Bantel Heike; Schmitz M Lienhard; Raible Armin; Gregor Michael; Schulze-Osthoff Klaus
Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1832-4.
2002: Stroh Christopher; Cassens Uwe; Samraj Ajoy K; Sibrowski Walter; Schulze-Osthoff Klaus; Los Marek
The role of caspases in cryoinjury: caspase inhibition strongly improves the recovery of cryopreserved hematopoietic and other cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1651-3.
2002: Bitzer Michael; Armeanu Sorin; Prinz Florian; Ungerechts Guy; Wybranietz Wolfgang; Spiegel Martin; Bernlöhr Christian; Cecconi Francesco; Gregor Michael; Neubert Wolfgang J; Schulze-Osthoff Klaus; Lauer Ulrich M
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.
The Journal of biological chemistry 2002;277(33):29817-24.
2002: Chlichlia Katerina; Los Marek; Schulze-Osthoff Klaus; Gazzolo Louis; Schirrmacher Volker; Khazaie Khashayarsha
Redox events in HTLV-1 Tax-induced apoptotic T-cell death.
Antioxidants & redox signaling 2002;4(3):471-7.
2002: Brehm Bernhard R; Wolf Sabine C; Freudenberg Jens; Friedmann Folkert; Heinle Helmut; Schulze-Osthoff Klaus
Modulation of the beta-adrenergic receptor system of vascular smooth muscle cells in vitro and in vivo by chronically elevated endothelin-1 levels.
Biochemical pharmacology 2002;63(7):1361-9.
2002: Los Marek; Mozoluk Malgorzata; Ferrari Davide; Stepczynska Anna; Stroh Christopher; Renz Andrea; Herceg Zdenko; Wang Zhao-Qi; Schulze-Osthoff Klaus
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.
Molecular biology of the cell 2002;13(3):978-88.
2002: Shpacovitch Victoria M; Brzoska Thomas; Buddenkotte Jörg; Stroh Christoph; Sommerhoff Christian P; Ansel John C; Schulze-Osthoff Klaus; Bunnett Nigel W; Luger Thomas A; Steinhoff Martin
Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells.
The Journal of investigative dermatology 2002;118(2):380-5.
2001: Berg C P; Engels I H; Rothbart A; Lauber K; Renz A; Schlosser S F; Schulze-Osthoff K; Wesselborg S
Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis.
Cell death and differentiation 2001;8(12):1197-206.
2001: Rudner J; Lepple-Wienhues A; Budach W; Berschauer J; Friedrich B; Wesselborg S; Schulze-Osthoff K; Belka C
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis.
Journal of cell science 2001;114(Pt 23):4161-72.
2001: Bantel H; Sinha B; Domschke W; Peters G; Schulze-Osthoff K; Jänicke R U
alpha-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling.
The Journal of cell biology 2001;155(4):637-48.
2001: Wieder T; Prokop A; Bagci B; Essmann F; Bernicke D; Schulze-Osthoff K; Dörken B; Schmalz H G; Daniel P T; Henze G
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(11):1735-42.
2001: Luetjens C M; Kögel D; Reimertz C; Düssmann H; Renz A; Schulze-Osthoff K; Nieminen A L; Poppe M; Prehn J H
Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.
Molecular pharmacology 2001;60(5):1008-19.
2001: Burek C; Roth J; Koch H G; Harzer K; Los M; Schulze-Osthoff K
The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells.
Oncogene 2001;20(45):6493-502.
2001: Bantel H; Lügering A; Poremba C; Lügering N; Held J; Domschke W; Schulze-Osthoff K
Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2001;34(4 Pt 1):758-67.
2001: Renz A; Berdel W E; Kreuter M; Belka C; Schulze-Osthoff K; Los M
Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo.
Blood 2001;98(5):1542-8.
2001: Held J; Schulze-Osthoff K
Potential and caveats of TRAIL in cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(4):243-52.
2001: Jänicke R U; Engels I H; Dunkern T; Kaina B; Schulze-Osthoff K; Porter A G
Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells.
Oncogene 2001;20(36):5043-53.
2001: Roth J; Goebeler M; Ludwig S; Wagner L; Kilian K; Sorg C; Harms E; Schulze-Osthoff K; Koch H
Homocysteine inhibits tumor necrosis factor-induced activation of endothelium via modulation of nuclear factor-kappa b activity.
Biochimica et biophysica acta 2001;1540(2):154-65.
2001: Lauber K; Appel H A; Schlosser S F; Gregor M; Schulze-Osthoff K; Wesselborg S
The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.
The Journal of biological chemistry 2001;276(32):29772-81.
2001: Daniel P T; Wieder T; Sturm I; Schulze-Osthoff K
The kiss of death: promises and failures of death receptors and ligands in cancer therapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(7):1022-32.
2001: Friedrich K; Wieder T; Von Haefen C; Radetzki S; Jänicke R; Schulze-Osthoff K; Dörken B; Daniel P T
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance.
Oncogene 2001;20(22):2749-60.
2001: Belka C; Schmid B; Marini P; Durand E; Rudner J; Faltin H; Bamberg M; Schulze-Osthoff K; Budach W
Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL.
Oncogene 2001;20(17):2190-6.
2001: Bantel H; Ruck P; Gregor M; Schulze-Osthoff K
Detection of elevated caspase activation and early apoptosis in liver diseases.
European journal of cell biology 2001;80(3):230-9.
2001: Stepczynska A; Lauber K; Engels I H; Janssen O; Kabelitz D; Wesselborg S; Schulze-Osthoff K
Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Oncogene 2001;20(10):1193-202.
2001: Wieder T; Essmann F; Prokop A; Schmelz K; Schulze-Osthoff K; Beyaert R; Dörken B; Daniel P T
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Blood 2001;97(5):1378-87.
2001: Brehm B R; Wolf S C; Bertsch D; Klaussner M; Wesselborg S; Schüler S; Schulze-Osthoff K
Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells.
Cardiovascular research 2001;49(2):430-9.
2001: Los M; Stroh C; Jänicke R U; Engels I H; Schulze-Osthoff K
Caspases: more than just killers?
Trends in immunology 2001;22(1):31-4.
2001: Schmidt M; Lügering N; Lügering A; Pauels H G; Schulze-Osthoff K; Domschke W; Kucharzik T
Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1344-51.
2001: Brehm B R; Bock C; Wesselborg S; Pfeiffer S; Schüler S; Schulze-Osthoff K
Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan.
Biochemical pharmacology 2001;61(1):119-27.
2001: Renz A; Burek C; Mier W; Mozoluk M; Schulze-Osthoff K; Los M
Cytochrome c is rapidly extruded from apoptotic cells and detectable in serum of anticancer-drug treated tumor patients.
Advances in experimental medicine and biology 2001;495():331-4.
2000: Bantel H; Berg C; Vieth M; Stolte M; Kruis W; Schulze-Osthoff K
Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis.
The American journal of gastroenterology 2000;95(12):3452-7.
2000: Hehner S P; Breitkreutz R; Shubinsky G; Unsoeld H; Schulze-Osthoff K; Schmitz M L; Dröge W
Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4319-28.
2000: Engels I H; Stepczynska A; Stroh C; Lauber K; Berg C; Schwenzer R; Wajant H; Jänicke R U; Porter A G; Belka C; Gregor M; Schulze-Osthoff K; Wesselborg S
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
Oncogene 2000;19(40):4563-73.
2000: Schmidt M; Lügering N; Pauels H G; Schulze-Osthoff K; Domschke W; Kucharzik T
IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway.
European journal of immunology 2000;30(6):1769-77.
2000: Los M; Neubüser D; Coy J F; Mozoluk M; Poustka A; Schulze-Osthoff K
Functional characterization of DNase X, a novel endonuclease expressed in muscle cells.
Biochemistry 2000;39(25):7365-73.
2000: Bantel H; Ruck P; Schulze-Osthoff K
In situ monitoring of caspase activation in hepatobiliary diseases.
Cell death and differentiation 2000;7(5):504-5.
2000: Belka C; Rudner J; Wesselborg S; Stepczynska A; Marini P; Lepple-Wienhues A; Faltin H; Bamberg M; Budach W; Schulze-Osthoff K
Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis.
Oncogene 2000;19(9):1181-90.
2000: Stier S; Totzke G; Grünewald E; Neuhaus T; Fronhoffs S; Sachinidis A; Vetter H; Schulze-Osthoff K; Ko Y
Identification of syntenin and other TNF-inducible genes in human umbilical arterial endothelial cells by suppression subtractive hybridization.
FEBS letters 2000;467(2-3):299-304.
1999: Belka C; Heinrich V; Marini P; Faltin H; Schulze-Osthoff K; Bamberg M; Budach W
Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells.
International journal of radiation biology 1999;75(10):1257-64.
1999: Belka C; Marini P; Lepple-Wienhues A; Budach W; Jekle A; Los M; Lang F; Schulze-Osthoff K; Gulbins E; Bamberg M
The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.
Oncogene 1999;18(35):4983-92.
1999: Fiebich B L; Hofer T J; Lieb K; Huell M; Butcher R D; Schumann G; Schulze-Osthoff K; Bauer J
The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha.
Neuropharmacology 1999;38(9):1325-33.
1999: Bantel H; Engels I H; Voelter W; Schulze-Osthoff K; Wesselborg S
Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis.
Cancer research 1999;59(9):2083-90.
1999: Ferrari D; Stroh C; Schulze-Osthoff K
P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells.
The Journal of biological chemistry 1999;274(19):13205-10.
1999: Wesselborg S; Engels I H; Rossmann E; Los M; Schulze-Osthoff K
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.
Blood 1999;93(9):3053-63.
1999: Ferrari D; Los M; Bauer M K; Vandenabeele P; Wesselborg S; Schulze-Osthoff K
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death.
FEBS letters 1999;447(1):71-5.
1999: Riehemann K; Behnke B; Schulze-Osthoff K
Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB.
FEBS letters 1999;442(1):89-94.
1999: Bitzer M; Prinz F; Bauer M; Spiegel M; Neubert W J; Gregor M; Schulze-Osthoff K; Lauer U
Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32).
Journal of virology 1999;73(1):702-8.
1998: Stroh C; Schulze-Osthoff K
Death by a thousand cuts: an ever increasing list of caspase substrates.
Cell death and differentiation 1998;5(12):997-1000.
1998: Bantel H; Brüning T; Schulze-Osthoff K
Activation of caspases by death receptors.
European cytokine network 1998;9(4):681-4.
1998: Los M; Khazaie K; Schulze-Osthoff K; Baeuerle P A; Schirrmacher V; Chlichlia K
Human T cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3050-5.
1998: Ferrari D; Stepczynska A; Los M; Wesselborg S; Schulze-Osthoff K
Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis.
The Journal of experimental medicine 1998;188(5):979-84.
1998: Schulze-Osthoff K; Ferrari D; Los M; Wesselborg S; Peter M E
Apoptosis signaling by death receptors.
European journal of biochemistry / FEBS 1998;254(3):439-59.
1998: Vogt M; Bauer M K; Ferrari D; Schulze-Osthoff K
Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells.
FEBS letters 1998;429(1):67-72.
1998: Belka C; Marini P; Budach W; Schulze-Osthoff K; Lang F; Gulbins E; Bamberg M
Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand.
Radiation research 1998;149(6):588-95.
1998: Bauer M K; Vogt M; Los M; Siegel J; Wesselborg S; Schulze-Osthoff K
Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression.
The Journal of biological chemistry 1998;273(14):8048-55.
1998: Hehner S P; Heinrich M; Bork P M; Vogt M; Ratter F; Lehmann V; Schulze-Osthoff K; Dröge W; Schmitz M L
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.
The Journal of biological chemistry 1998;273(3):1288-97.
1997: Ferrari D; Wesselborg S; Bauer M K; Schulze-Osthoff K
Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65.
The Journal of cell biology 1997;139(7):1635-43.
1997: Lieb K; Fiebich B L; Berger M; Bauer J; Schulze-Osthoff K
The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4952-8.
1997: Wesselborg S; Bauer M K; Vogt M; Schmitz M L; Schulze-Osthoff K
Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.
The Journal of biological chemistry 1997;272(19):12422-9.
1997: Bauer M K; Lieb K; Schulze-Osthoff K; Berger M; Gebicke-Haerter P J; Bauer J; Fiebich B L
Expression and regulation of cyclooxygenase-2 in rat microglia.
European journal of biochemistry / FEBS 1997;243(3):726-31.
1997: Bauer M K; Wesselborg S; Schulze-Osthoff K
The Caenorhabditis elegans death protein Ced-4 contains a motif with similarity to the mammalian 'death effector domain'.
FEBS letters 1997;402(2-3):256-8.
1997: Schulze-Osthoff K; Bauer M K; Vogt M; Wesselborg S
Oxidative stress and signal transduction.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1997;67(5):336-42.
1996: Ratter F; Germer M; Fischbach T; Schulze-Osthoff K; Peter M E; Dröge W; Krammer P H; Lehmann V
S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.
International immunology 1996;8(7):1139-47.
1996: Grimm S; Bauer M K; Baeuerle P A; Schulze-Osthoff K
Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.
The Journal of cell biology 1996;134(1):13-23.
1996: Schulze-Osthoff K; Bauer M K; Vogt M; Los M
Role of ICE-related and other proteases in Fas-mediated apoptosis.
Cell death and differentiation 1996;3(2):177-84.
1996: Pahl H L; Krauss B; Schulze-Osthoff K; Decker T; Traenckner E B; Vogt M; Myers C; Parks T; Warring P; Mühlbacher A; Czernilofsky A P; Baeuerle P A
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.
The Journal of experimental medicine 1996;183(4):1829-40.
1996: Schenk H; Vogt M; Dröge W; Schulze-Osthoff K
Thioredoxin as a potent costimulus of cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):765-71.
1995: Schulze-Osthoff K; Los M; Baeuerle P A
Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes.
Biochemical pharmacology 1995;50(6):735-41.
1995: Los M; Schenk H; Hexel K; Baeuerle P A; Dröge W; Schulze-Osthoff K
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
The EMBO journal 1995;14(15):3731-40.
1995: Los M; Van de Craen M; Penning L C; Schenk H; Westendorp M; Baeuerle P A; Dröge W; Krammer P H; Fiers W; Schulze-Osthoff K
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.
Nature 1995;375(6526):81-3.
1995: Westendorp M O; Shatrov V A; Schulze-Osthoff K; Frank R; Kraft M; Los M; Krammer P H; Dröge W; Lehmann V
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
The EMBO journal 1995;14(3):546-54.
1995: Los M; Dröge W; Stricker K; Baeuerle P A; Schulze-Osthoff K
Hydrogen peroxide as a potent activator of T lymphocyte functions.
European journal of immunology 1995;25(1):159-65.
1995: Schulze-Osthoff K; Schenk H; Dröge W
Effects of thioredoxin on activation of transcription factor NF-kappa B.
Methods in enzymology 1995;252():253-64.
1994: Dröge W; Schulze-Osthoff K; Mihm S; Galter D; Schenk H; Eck H P; Roth S; Gmünder H
Functions of glutathione and glutathione disulfide in immunology and immunopathology.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(14):1131-8.
1994: Schulze-Osthoff K; Walczak H; Dröge W; Krammer P H
Cell nucleus and DNA fragmentation are not required for apoptosis.
The Journal of cell biology 1994;127(1):15-20.
1994: Schulze-Osthoff K; Krammer P H; Dröge W
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.
The EMBO journal 1994;13(19):4587-96.
1994: Los M; Dröge W; Schulze-Osthoff K
Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.
The Biochemical journal 1994;302 ( Pt 1)():119-23.
1994: Bergmann S; Shatrov V; Ratter F; Schiemann S; Schulze-Osthoff K; Lehmann V
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1736-43.
1994: Schenk H; Klein M; Erdbrügger W; Dröge W; Schulze-Osthoff K
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1672-6.

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