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Klaus Schulze-Osthoff

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Chemicals & Drugs

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Dominic G Hildebrand; Sebastian Hörber; Simon Lehle; Masami Morimatsu; Niels-Arne Münck; Kerstin Obermayer; Johannes Roth; Oliver Rothfuss; Ingo Schmitz; Eva Alexander; Jan Ehrchen; Frank Essmann; Julia-Stefanie Frick; Klaus Schulze-Osthoff
IκBζ Is a Transcriptional Key Regulator of CCL2/MCP-1.
Heike Bantel; Klaus Schulze-Osthoff
TNF Antagonists in IBD: Novel Antiinflammatory Mechanisms Beyond Cytokine Inhibition.
Heidi Braumüller; Kilian Braungart; Ellen Brenner; Frank Essmann; Birgit Fehrenbacher; Falko Fend; Christoph Griessinger; Matthias Hahn; Rupert Handgretinger; Hans-Ulrich Häring; Manfred Kneilling; Tarun Mehra; Friedegund Meier; Ralph Mocikat; Heike Niessner; Marina Pesic; Leticia Quintanilla-Martinez; Felicia Ranta; Mohammed Alkhaled; Sonja Aßmann; Jürgen Bauer; Julia Berdel; Martin Schaller; Karin Schilbach; Klaus Schulze-Osthoff; Susanne Ullrich; Maries van den Broek; Thomas Wieder; Lars Zender; Martin Röcken
T-helper-1-cell cytokines drive cancer into senescence.

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All Publications

2013: Dominic G Hildebrand; Sebastian Hörber; Simon Lehle; Masami Morimatsu; Niels-Arne Münck; Kerstin Obermayer; Johannes Roth; Oliver Rothfuss; Ingo Schmitz; Eva Alexander; Jan Ehrchen; Frank Essmann; Julia-Stefanie Frick; Klaus Schulze-Osthoff
IκBζ Is a Transcriptional Key Regulator of CCL2/MCP-1.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4812-20.
2013: Heike Bantel; Klaus Schulze-Osthoff
TNF Antagonists in IBD: Novel Antiinflammatory Mechanisms Beyond Cytokine Inhibition.
Inflammatory bowel diseases 2013;19(4):E51-2.
2013: Heidi Braumüller; Kilian Braungart; Ellen Brenner; Frank Essmann; Birgit Fehrenbacher; Falko Fend; Christoph Griessinger; Matthias Hahn; Rupert Handgretinger; Hans-Ulrich Häring; Manfred Kneilling; Tarun Mehra; Friedegund Meier; Ralph Mocikat; Heike Niessner; Marina Pesic; Leticia Quintanilla-Martinez; Felicia Ranta; Mohammed Alkhaled; Sonja Aßmann; Jürgen Bauer; Julia Berdel; Martin Schaller; Karin Schilbach; Klaus Schulze-Osthoff; Susanne Ullrich; Maries van den Broek; Thomas Wieder; Lars Zender; Martin Röcken
T-helper-1-cell cytokines drive cancer into senescence.
Nature 2013;494(7437):361-5.
2013: E Keil; D A Liebermann; K Pfeffer; Frank Essmann; R Höcker; B Hoffman; Klaus Schulze-Osthoff; M Schuster; N Ueffing; I Schmitz
Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy.
Cell death and differentiation 2013;20(2):321-32.
2013: Kristin Wahl; Roland Kontermann; Till Krech; Florian Länger; Frank Lehner; Michael P Manns; Andreas Nüssler; Klaus Pfizenmaier; Klaus Schulze-Osthoff; Martin Siegemund; Florian Vondran; Heike Bantel
Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib.
Hepatology (Baltimore, Md.) 2013;57(2):625-36.
2012: Matthias Rosenwald; Guido Sauer; Klaus Schulze-Osthoff; Sebastian Wesselborg; Christoph Peter; Claus Belka; Karin Erika Blume; Anne Ernst; Roman Hennel; Martin Herrmann; Hildegard Keppeler; Uwe Koppe; Kirsten Lauber
Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(12):5722-8.
2012: Marc Schuster; Britta Siegmund; Tim D. Sparwasser; Lisa Schreiber; Klaus Schulze-Osthoff; Michaela Annemann; Linda K Clayton; Stefan Floess; Rainer Glauben; Jochen Huehn; Anja A Kühl; Klaus Pfeffer; Carlos Plaza-Sirvent; Ingo Schmitz
IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.
Immunity 2012;37(6):998-1008.
2012: Christoph Peter; Klaus Schulze-Osthoff; Michaela Waibel; Sebastian Wesselborg; Guowang Xu; Jerzy Adamski; Anna Halama; Hildegard Keppeler; Rainer Lehmann; Kirsten Lauber
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
Autoimmunity 2012;45(8):568-73.
2012: Elodie Lafont; Thierry Levade; Toshiro Okazaki; Klaus Schulze-Osthoff; Nathalie Andrieu-Abadie; Hervé Benoist; Romain Dupont; Bruno Ségui
Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis.
Biochimica et biophysica acta 2012;1821(4):684-93.
2012: Verena Wilhelmi; Ute Fischer; Roel P F Schins; Klaus Schulze-Osthoff; Damiën van Berlo; Catrin Albrecht
Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts.
Toxicology in vitro : an international journal published in association with BIBRA 2012;26(2):323-34.
2012: Diana Joka; Michael P Manns; Sarah Moeller; Jerome Schlue; Klaus Schulze-Osthoff; Bernhard Vaske; Kristin Wahl; Matthias J Bahr; Heike Bantel
Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2012;55(2):455-64.
2012: Kristin Wahl; Matthias J Bahr; Michael P Manns; William Rosenberg; Klaus Schulze-Osthoff; Bernhard Vaske; Heike Bantel
Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography.
PloS one 2012;7(12):e51906.
2012: Heike Bantel; Klaus Schulze-Osthoff
Mechanisms of cell death in acute liver failure.
Frontiers in physiology 2012;3():79.
2011: Kamran Ghoreschi; Ivana Glocova; Anne R Gocke; Rehana Z Hussain; Christina Kellerer; Amy E Lovett-Racke; Haiyan Peng; Michael K Racke; Annedore Respa; Eva Alexander; Jürgen Brück; Caishu Deng; Ralf Dringen; Robert Feil; Susanne Feil; Oliver Rothfuss; Rudolf A Rupec; Klaus Schulze-Osthoff; Nadejda Valtcheva; Martin Röcken
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells.
The Journal of experimental medicine 2011;208(11):2291-303.
2011: Federica Cappuccini; Therese Eldh; Ute Fischer; Marcus Gereke; Holger Jastrow; David Köhler; Klaus Schulze-Osthoff; Martin Stuschke; Dunja Bruder; Verena Jendrossek
New insights into the molecular pathology of radiation-induced pneumopathy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011;101(1):86-92.
2011: Claudia Veltkamp; Kristin Wahl; Matthias Anstaett; Oliver Bachmann; Saskia Gangl; Matthias Hardtke-Wolenski; Florian Länger; Michael P Manns; Sarah Möller; Klaus Schulze-Osthoff; Wolfgang Stremmel; Heike Bantel
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment.
Gut 2011;60(10):1345-53.
2011: Joachim Manns; Florian Paasch; Klaus Schulze-Osthoff; Björn Stork; Sebastian Alers; Merle Daubrawa; Alexandra Dieterle; Stefan Driessen; Nadine Hoffmann; Thomas Iftner; Kirsten Lauber; Antje Löffler; Sebastian Wesselborg
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(9):3250-61.
2011: V Graupner; T Overkamp; O Rothfuss; Klaus Schulze-Osthoff; E Alexander; Peter Daniel; V De Laurenzi; Bernhard Gillissen; Frank Essmann
Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level.
Cell death and differentiation 2011;18(7):1130-9.
2011: Klaus Schulze-Osthoff; Heike Bantel
Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity.
Hepatology (Baltimore, Md.) 2011;53(3):1070.
2011: Gernot Guderian; Christoph Peter; Julia Wiesner; Albert Sickmann; Klaus Schulze-Osthoff; Utz Fischer; Matthias Grimmler
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
The Journal of biological chemistry 2011;286(3):1976-86.
2010: Kusum Singh; Steffen Erkelenz; Stephanie Rattay; Anna Katharina Dehof; Andreas Hildebrandt; Klaus Schulze-Osthoff; Heiner Schaal; Christian Schwerk
Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.
RNA (New York, N.Y.) 2010;16(12):2442-54.
2010: S Schmidt; Leonid Schneider; Frank Essmann; I C Cirstea; F Kuck; Anja Kletke; Reiner U Jänicke; C Wiek; Helmut Hanenberg; M R Ahmadian; Klaus Schulze-Osthoff; Bernd Nürnberg; Roland P Piekorz
The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
Oncogene 2010;29(46):6184-92.
2010: Stephen Schmidt; Frank Essmann; Fabian Kuck; Harish C Thakur; Madhurendra Singh; Anja Kletke; Reiner U Jänicke; Constanze Wiek; Helmut Hanenberg; M Reza Ahmadian; Klaus Schulze-Osthoff; Bernd Nürnberg; Ion C Cirstea; Roland P Piekorz
The centrosome and mitotic spindle apparatus in cancer and senescence.
Cell cycle (Georgetown, Tex.) 2010;9(22):4469-73.
2010: Doreen Brandt; Xandra Volkmann; Matthias Anstätt; Florian Länger; Michael P Manns; Klaus Schulze-Osthoff; Heike Bantel
Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas.
European journal of cancer (Oxford, England : 1990) 2010;46(8):1464-73.
2009: Karin E Blume; Szabolcs Soeroes; Michaela Waibel; Hildegard Keppeler; Sebastian Wesselborg; Martin Herrmann; Klaus Schulze-Osthoff; Kirsten Lauber
Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):8138-47.
2009: Katja Janssen; Sibylle Horn; Mathis T Niemann; Peter T Daniel; Klaus Schulze-Osthoff; Ute Fischer
Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis.
Journal of cell science 2009;122(Pt 24):4481-91.
2009: Ilaria Dalla Rosa; Steffi Goffart; Melanie Wurm; Constanze Wiek; Frank Essmann; Stefan Sobek; Peter Schroeder; Hongliang Zhang; Jean Krutmann; Helmut Hanenberg; Klaus Schulze-Osthoff; Christian Mielke; Yves Pommier; Fritz Boege; Morten Christensen
Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.
Nucleic acids research 2009;37(19):6414-28.
2009: Heike Bantel; Matthias J Bahr; Klaus Schulze-Osthoff
An apoptosis biomarker for prediction of nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2009;50(3):991.
2009: Marek Los; Soumya Panigrahi; Iran Rashedi; Sanat Mandal; Joerg Stetefeld; Frank Essmann; Klaus Schulze-Osthoff
Apoptin, a tumor-selective killer.
Biochimica et biophysica acta 2009;1793(8):1335-42.
2009: Nana Ueffing; Kusum Singh; Andrea Christians; Christoph Thorns; Alfred C Feller; Florian Nagl; Falko Fend; Sebastian Heikaus; Alexander Marx; Rainer B Zotz; Joachim Brade; Wolfgang A Schulz; Klaus Schulze-Osthoff; Ingo Schmitz; Christian Schwerk
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein.
Blood 2009;114(3):572-9.
2009: Marek Los; Klaus Schulze-Osthoff
Catching chromatin relaxation in act by flow cytometry.
Cell cycle (Georgetown, Tex.) 2009;8(14):2140-1.
2009: Charlotte Lindenblatt; Klaus Schulze-Osthoff; Gudrun Totzke
IkappaBzeta expression is regulated by miR-124a.
Cell cycle (Georgetown, Tex.) 2009;8(13):2019-23.
2009: Stefan Hofer; Claudia Rosenhagen; Hajime Nakamura; Junji Yodoi; Christian Bopp; Johannes B Zimmermann; Meike Goebel; Peter Schemmer; Kartrin Hoffmann; Klaus Schulze-Osthoff; Raoul Breitkreutz; Markus A Weigand
Thioredoxin in human and experimental sepsis.
Critical care medicine 2009;37(7):2155-9.
2009: Dennis Sohn; V Graupner; D Neise; Frank Essmann; Klaus Schulze-Osthoff; Reiner U Jänicke
Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.
Cell death and differentiation 2009;16(6):869-78.
2009: Marek Los; Subbareddy Maddika; Bettina Erb; Klaus Schulze-Osthoff
Switching Akt: from survival signaling to deadly response.
BioEssays : news and reviews in molecular, cellular and developmental biology 2009;31(5):492-5.
2009: Vilma Graupner; Klaus Schulze-Osthoff; Frank Essmann; Reiner U Jänicke
Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53.
Cell cycle (Georgetown, Tex.) 2009;8(8):1238-48.
2009: Subbareddy Maddika; Soumya Panigrahi; Emilia Wiechec; Sebastian Wesselborg; Ute Fischer; Klaus Schulze-Osthoff; Marek Los
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Molecular and cellular biology 2009;29(5):1235-48.
2009: Heike Bantel; Klaus Schulze-Osthoff
Cell death in sepsis: a matter of how, when, and where.
Critical care (London, England) 2009;13(4):173.
2008: A Rudy; Nancy López-Antón; N Barth; George R Pettit; Verena M Dirsch; Klaus Schulze-Osthoff; Markus Rehm; J H M Prehn; M Vogler; S Fulda; Nicole Barth
Role of Smac in cephalostatin-induced cell death.
Cell death and differentiation 2008;15(12):1930-40.
2008: Sabine Hombach-Klonisch; Soumya Panigrahi; Iran Rashedi; Anja Seifert; Esteban Alberti; Paola Pocar; Maciej Kurpisz; Klaus Schulze-Osthoff; Andrzej Mackiewicz; Marek Los
Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications.
Journal of molecular medicine (Berlin, Germany) 2008;86(12):1301-14.
2008: Thomas Klonisch; Emilia Wiechec; Sabine Hombach-Klonisch; Sudharsana R Ande; Sebastian Wesselborg; Klaus Schulze-Osthoff; Marek Los
Cancer stem cell markers in common cancers - therapeutic implications.
Trends in molecular medicine 2008;14(10):450-60.
2008: Nana Ueffing; Marc Schuster; Eric Keil; Klaus Schulze-Osthoff; Ingo Schmitz
Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells.
Blood 2008;112(3):690-8.
2008: M Hassan; A Alaoui; Oliver Feyen; Alireza Mirmohammadsadegh; Frank Essmann; Andrea Tannapfel; E Gulbins; Klaus Schulze-Osthoff; Ulrich R Hengge
The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways.
Oncogene 2008;27(33):4557-68.
2008: Jan Julius Stampfuss; Petra Censarek; Jens W Fischer; Gernot Kaber; Bernhard H Rauch; Kerstin Freidel; Ute Fischer; Klaus Schulze-Osthoff; Tilo Grosser; Maria Grandoch; Karsten Schrör; Artur-Aron Weber
Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1375-8.
2008: Reiner U Jänicke; Dennis Sohn; Klaus Schulze-Osthoff
The dark side of a tumor suppressor: anti-apoptotic p53.
Cell death and differentiation 2008;15(6):959-76.
2008: Subbareddy Maddika; Emilia Wiechec; Sudharsana Rao Ande; I K Poon; U Fischer; Sebastian Wesselborg; D A Jans; Klaus Schulze-Osthoff; Marek Los
Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin.
Oncogene 2008;27(21):3060-5.
2008: Sabine Hombach-Klonisch; Ted Paranjothy; Emilia Wiechec; Paola Pocar; Tarek Mustafa; Anja Seifert; Christian Zahl; Klaus Luis Gerlach; Katharina Biermann; Klaus Steger; Cuong Hoang-Vu; Klaus Schulze-Osthoff; Marek Los
Cancer stem cells as targets for cancer therapy: selected cancers as examples.
Archivum immunologiae et therapiae experimentalis 2008;56(3):165-80.
2008: Xandra Volkmann; Matthias Anstaett; Johannes Hadem; Penelope Stiefel; Matthias J Bahr; Frank Lehner; Michael P Manns; Klaus Schulze-Osthoff; Heike Bantel
Caspase activation is associated with spontaneous recovery from acute liver failure.
Hepatology (Baltimore, Md.) 2008;47(5):1624-33.
2008: N Ueffing; E Keil; C Freund; R Kühne; Klaus Schulze-Osthoff; Ingo Schmitz
Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment.
Cell death and differentiation 2008;15(4):773-82.
2008: Christoph Peter; Michaela Waibel; Caius G Radu; Li V Yang; Owen N Witte; Klaus Schulze-Osthoff; Sebastian Wesselborg; Kirsten Lauber
Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
The Journal of biological chemistry 2008;283(9):5296-305.
2008: D Neise; V Graupner; Bernhard Gillissen; Peter Daniel; Klaus Schulze-Osthoff; Reiner U Jänicke; Frank Essmann
Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak.
Oncogene 2008;27(10):1387-96.
2008: Saeid Ghavami; Claus Kerkhoff; Walter J Chazin; Kamran Kadkhoda; Wenyan Xiao; Anne Zuse; Mohammad Hashemi; Mehdi Eshraghi; Klaus Schulze-Osthoff; Thomas Klonisch; Marek Los
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
Biochimica et biophysica acta 2008;1783(2):297-311.
2008: Leonid Schneider; Frank Essmann; Anja Kletke; Paula Rio; Helmut Hanenberg; Klaus Schulze-Osthoff; Bernd Nürnberg; Roland P Piekorz
TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest.
Oncogene 2008;27(1):116-25.
2008: Jürgen Knobloch; Ingo Schmitz; Katrin Götz; Klaus Schulze-Osthoff; Ulrich Rüther
Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death.
Molecular and cellular biology 2008;28(2):529-38.
2008: Irina Tretiakova; Dagmar Blaesius; Lucia Maxia; Sebastian Wesselborg; Klaus Schulze-Osthoff; Jindrich Cinatl; Martin Michaelis; Oliver Werz
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9.
Apoptosis : an international journal on programmed cell death 2008;13(1):119-31.
2007: Ute Fischer; Katja Janssen; Klaus Schulze-Osthoff
Does caspase inhibition promote clonogenic tumor growth?
Cell cycle (Georgetown, Tex.) 2007;6(24):3048-53.
2007: Katja Janssen; Stephan Pohlmann; Reiner U Jänicke; Klaus Schulze-Osthoff; Ute Fischer
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment.
Blood 2007;110(10):3662-72.
2007: Xandra Volkmann; Ute Fischer; Matthias J Bahr; Michael Ott; Frank Lehner; Marion Macfarlane; Gerald M Cohen; Michael P Manns; Klaus Schulze-Osthoff; Heike Bantel
Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver.
Hepatology (Baltimore, Md.) 2007;46(5):1498-508.
2007: Leonid Schneider; Frank Essmann; Anja Kletke; Paula Rio; Helmut Hanenberg; Wiebke Wetzel; Klaus Schulze-Osthoff; Bernd Nürnberg; Roland P Piekorz
The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.
The Journal of biological chemistry 2007;282(40):29273-83.
2007: Klaus Schulze-Osthoff; Dieter Häussinger
Apoptosis in the liver: a matter of ion fluxes and oxidative stress: Third International Conference of the Collaborative Research Center 'Experimental Hepatology' (SFB-575), Düsseldorf, Germany, 13-14 October 2006.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(8):1039-44.
2007: Robert Werdehausen; Sebastian Braun; Frank Essmann; Klaus Schulze-Osthoff; Henning Walczak; Peter Lipfert; Markus F Stevens
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
Anesthesiology 2007;107(1):136-43.
2007: Anja Troeger; Ingo Schmitz; Meinolf Siepermann; Ludmila Glouchkova; Ulrike Gerdemann; Gritta E Janka-Schaub; Klaus Schulze-Osthoff; Dagmar Dilloo
Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL.
Blood 2007;110(1):384-7.
2007: Polya Vutova; Martina Wirth; Diana Hippe; Uwe Gross; Klaus Schulze-Osthoff; Ingo Schmitz; Carsten G K Lüder
Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8.
Cellular microbiology 2007;9(6):1556-70.
2007: Dorothee Viemann; Katarzyna Barczyk; Thomas Vogl; Ute Fischer; Cord Sunderkötter; Klaus Schulze-Osthoff; Johannes Roth
MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program.
Blood 2007;109(6):2453-60.
2007: K Janssen; Thomas G Hofmann; D A Jans; Ron Thomas Hay; Klaus Schulze-Osthoff; Ute Fischer
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.
Oncogene 2007;26(11):1557-66.
2007: Michaela Waibel; Stefan Kramer; Kirsten Lauber; Adrian Lupescu; Joachim Manns; Klaus Schulze-Osthoff; Florian Lang; Sebastian Wesselborg
Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis.
Apoptosis : an international journal on programmed cell death 2007;12(3):623-30.
2007: Reiner U Jänicke; Dennis Sohn; Frank Essmann; Klaus Schulze-Osthoff
The multiple battles fought by anti-apoptotic p21.
Cell cycle (Georgetown, Tex.) 2007;6(4):407-13.
2007: Ute Fischer; Katja Janssen; Klaus Schulze-Osthoff
Cutting-edge apoptosis-based therapeutics: a panacea for cancer?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2007;21(5):273-97.
2007: Ajoy K Samraj; Dennis Sohn; Klaus Schulze-Osthoff; Ingo Schmitz
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization.
Molecular biology of the cell 2007;18(1):84-93.
2006: Ingo Schmitz; C Meyer; Klaus Schulze-Osthoff
CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma.
Oncogene 2006;25(58):7587-96.
2006: Dennis Sohn; Frank Essmann; Klaus Schulze-Osthoff; Reiner U Jänicke
p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation.
Cancer research 2006;66(23):11254-62.
2006: Nancy López-Antón; Anita Rudy; Nicole Barth; M Lienhard Schmitz; Lienhard M Schmitz; George R Pettit; Klaus Schulze-Osthoff; Verena M Dirsch; Nicole Barth
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway.
The Journal of biological chemistry 2006;281(44):33078-86.
2006: Ajoy K Samraj; Eric Keil; Nana Ueffing; Klaus Schulze-Osthoff; Ingo Schmitz
Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis.
The Journal of biological chemistry 2006;281(40):29652-9.
2006: Christoph P Berg; Gerburg M Stein; Reinhild Klein; Maria Pascu; Thomas Berg; Winfried Kammer; Martin Priemer; Alfred Nordheim; Klaus Schulze-Osthoff; Michael Gregor; Sebastian Wesselborg; Peter A Berg
Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(7):846-55.
2006: Bettina Haslinger-Löffler; B Wagner; Michaela Brück; Katrin Strangfeld; Matthias Grundmeier; U Fischer; W Völker; Georg Peters; Klaus Schulze-Osthoff; Bhanu Sinha
Staphylococcus aureus induces caspase-independent cell death in human peritoneal mesothelial cells.
Kidney international 2006;70(6):1089-98.
2006: Reiner U Jänicke; Dennis Sohn; Gudrun Totzke; Klaus Schulze-Osthoff
Caspase-10 in mouse or not?
Science (New York, N.Y.) 2006;312(5782):1874.
2006: Xandra Volkmann; Markus Cornberg; Heiner Wedemeyer; Frank Lehner; Michael P Manns; Klaus Schulze-Osthoff; Heike Bantel
Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2006;43(6):1311-6.
2006: Alvin Joselin; Klaus Schulze-Osthoff; Christian Schwerk
Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis.
The Journal of biological chemistry 2006;281(18):12475-84.
2006: Gudrun Totzke; Frank Essmann; Stephan Pohlmann; Charlotte Lindenblatt; Reiner U Jänicke; Klaus Schulze-Osthoff
A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.
The Journal of biological chemistry 2006;281(18):12645-54.
2006: Volker Stoldt; Oliver Schnorr; Klaus Schulze-Osthoff; Rüdiger E Scharf
Transforming growth factor-beta1 enhances the antifibrinolytic and prothrombotic state of growing endothelial cells in a cell cycle-specific manner.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):965-6.
2006: Kai Zacharowski; Paula A Zacharowski; Alexander Koch; Aida Baban; Nguyen Tran; Reinhard Berkels; Claudia Papewalis; Klaus Schulze-Osthoff; Pascal Knuefermann; Ulrich Zähringer; Ralf R Schumann; Valeria Rettori; Samuel M McCann; Stefan R Bornstein
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6392-7.
2006: Sabine C Wolf; Michael Schultze; Teut Risler; Timo Rieg; Florian Lang; Klaus Schulze-Osthoff; Bernhard R Brehm
Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1.
Biochemical pharmacology 2006;71(8):1175-83.
2006: M Burek; Subbareddy Maddika; Christof J Burek; Peter Daniel; Klaus Schulze-Osthoff; Marek Los
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.
Oncogene 2006;25(15):2213-22.
2006: Dennis Sohn; Gudrun Totzke; Klaus Schulze-Osthoff; Reiner U Jänicke
Friend or foe? The proteasome in combined cancer therapy.
Cell cycle (Georgetown, Tex.) 2006;5(8):841-5.
2006: Dennis Sohn; Gudrun Totzke; Frank Essmann; Klaus Schulze-Osthoff; Bodo Levkau; Reiner U Jänicke
The proteasome is required for rapid initiation of death receptor-induced apoptosis.
Molecular and cellular biology 2006;26(5):1967-78.
2006: Jana Wendt; Silke Radetzki; Clarissa von Haefen; Philipp G Hemmati; Dilek Güner; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.
Oncogene 2006;25(7):972-80.
2006: Ajoy K Samraj; Christopher Stroh; Ute Fischer; Klaus Schulze-Osthoff
The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression.
Oncogene 2006;25(2):186-97.
2006: Ute Fischer; Christopher Stroh; Klaus Schulze-Osthoff
Unique and overlapping substrate specificities of caspase-8 and caspase-10.
Oncogene 2006;25(1):152-9.
2005: Dorothee Viemann; Klaus Schulze-Osthoff; Johannes Roth
Potentials and pitfalls of DNA array analysis of the endothelial stress response.
Biochimica et biophysica acta 2005;1746(2):73-84.
2005: Frank Essmann; Stephan Pohlmann; Bernhard Gillissen; Peter Daniel; Klaus Schulze-Osthoff; Reiner U Jänicke
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis.
The Journal of biological chemistry 2005;280(44):37169-77.
2005: Christian Schwerk; Klaus Schulze-Osthoff
Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death.
Oncogene 2005;24(47):7002-11.
2005: Christian Scholz; Antje Richter; Mario Lehmann; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway.
Oncogene 2005;24(47):7031-42.
2005: Heike Bantel; Thomas Beikler; Thomas F Flemmig; Klaus Schulze-Osthoff
Caspase activation is involved in chronic periodontitis.
FEBS letters 2005;579(25):5559-64.
2005: Daniela Siegmund; Andreas Wicovsky; Ingo Schmitz; Klaus Schulze-Osthoff; Sebastian Kreuz; Martin Leverkus; Oliver Dittrich-Breiholz; Michael Kracht; Harald Wajant
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing.
Molecular and cellular biology 2005;25(15):6363-79.
2005: Bettina Haslinger-Löffler; Barbara C Kahl; Matthias Grundmeier; Katrin Strangfeld; Britta Wagner; Ute Fischer; Ambrose L Cheung; Georg Peters; Klaus Schulze-Osthoff; Bhanu Sinha
Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells.
Cellular microbiology 2005;7(8):1087-97.
2005: Ute Fischer; Klaus Schulze-Osthoff
Apoptosis-based therapies and drug targets.
Cell death and differentiation 2005;12 Suppl 1():942-61.
2005: Christian Schwerk; Klaus Schulze-Osthoff
Regulation of apoptosis by alternative pre-mRNA splicing.
Molecular cell 2005;19(1):1-13.
2005: Nicole Seidel; Xandra Volkmann; Florian Länger; Peer Flemming; Michael P Manns; Klaus Schulze-Osthoff; Heike Bantel
The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum.
Hepatology (Baltimore, Md.) 2005;42(1):113-20.
2005: Ute Fischer; Klaus Schulze-Osthoff
New approaches and therapeutics targeting apoptosis in disease.
Pharmacological reviews 2005;57(2):187-215.
2005: Ingo H Engels; Gudrun Totzke; Ute Fischer; Klaus Schulze-Osthoff; Reiner U Jänicke
Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner.
Molecular and cellular biology 2005;25(7):2808-18.
2005: Christian Scholz; Thomas Wieder; Lilian Stärck; Frank Essmann; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway.
Oncogene 2005;24(11):1904-13.
2005: Dennis Sohn; Klaus Schulze-Osthoff; Reiner U Jänicke
Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis.
The Journal of biological chemistry 2005;280(7):5267-73.
2005: Ute Fischer; Sabine Steffens; Susanne Frank; Nikolai G Rainov; Klaus Schulze-Osthoff; Christof M Kramm
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.
Oncogene 2005;24(7):1231-43.
2005: Jörg Buddenkotte; Christopher Stroh; Ingo H Engels; Corinna Moormann; Victoria M Shpacovitch; Stephan Seeliger; Nathalie Vergnolle; Dietmar Vestweber; Thomas A Luger; Klaus Schulze-Osthoff; Martin Steinhoff
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
The Journal of investigative dermatology 2005;124(1):38-45.
2004: Antje Klöpfer; Anne Hasenjäger; Claus Belka; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway.
Oncogene 2004;23(58):9408-18.
2004: Stefan R Bornstein; Paula A Zacharowski; Ralf R Schumann; Andreas Barthel; Nguyen Tran; Claudia Papewalis; Valeria Rettori; Samuel M McCann; Klaus Schulze-Osthoff; Werner A Scherbaum; Jörg Tarnow; Kai Zacharowski
Impaired adrenal stress response in Toll-like receptor 2-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16695-700.
2004: Heike Bantel; Andreas Lügering; Jan Heidemann; Xandra Volkmann; Christopher Poremba; Christian P Strassburg; Michael Peter Manns; Klaus Schulze-Osthoff
Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury.
Hepatology (Baltimore, Md.) 2004;40(5):1078-87.
2004: Frank Essmann; Ingo H Engels; Gudrun Totzke; Klaus Schulze-Osthoff; Reiner U Jänicke
Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event.
Cancer research 2004;64(19):7065-72.
2004: Karin Schmelz; Thomas Wieder; Ingo Tamm; Antje Müller; Frank Essmann; Christoph C Geilen; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.
Oncogene 2004;23(40):6743-59.
2004: Frank U Müller; Karin Loser; U Kleideiter; J Neumann; C von Wallbrunn; T Dobner; H-H Scheld; Heike Bantel; Ingo H Engels; Klaus Schulze-Osthoff; Wilhelm Schmitz
Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes.
Cell death and differentiation 2004;11(5):485-93.
2004: Pushpa Pandiyan; Dagmar Gärtner; Osman Soezeri; Andreas Radbruch; Klaus Schulze-Osthoff; Monika C Brunner-Weinzierl
CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.
The Journal of experimental medicine 2004;199(6):831-42.
2003: Dominik Krilleke; Esat Ucur; Dianne Pulte; Klaus Schulze-Osthoff; Klaus-Michael Debatin; Ingrid Herr
Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis.
International journal of cancer. Journal international du cancer 2003;107(4):520-7.
2003: Frank Essmann; Heike Bantel; Gudrun Totzke; Ingo H Engels; Bhanu Sinha; Klaus Schulze-Osthoff; Reiner U Jänicke
Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation.
Cell death and differentiation 2003;10(11):1260-72.
2003: Christian Schwerk; Klaus Schulze-Osthoff
Non-apoptotic functions of caspases in cellular proliferation and differentiation.
Biochemical pharmacology 2003;66(8):1453-8.
2003: Bettina Haslinger; Katrin Strangfeld; Georg Peters; Klaus Schulze-Osthoff; Bhanu Sinha
Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway.
Cellular microbiology 2003;5(10):729-41.
2003: Gudrun Totzke; Klaus Schulze-Osthoff; Reiner U Jänicke
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.
Oncogene 2003;22(39):8021-30.
2003: Christopher Stroh; Jürgen Held; Ajoy K Samraj; Klaus Schulze-Osthoff
Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22.
Oncogene 2003;22(34):5367-73.
2003: Bernhard Gillissen; Frank Essmann; Vilma Graupner; Lilian Stärck; Silke Radetzki; Bernd Dörken; Klaus Schulze-Osthoff; Peter Daniel
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
The EMBO journal 2003;22(14):3580-90.
2003: Kirsten Lauber; Erwin Bohn; Stefan Kröber; Yi-jin Xiao; Sibylle G Blumenthal; Ralph K Lindemann; Patrizia Marini; Carolin A Wiedig; Anke Zobywalski; Shairaz Baksh; Yan Xu; Ingo B Autenrieth; Klaus Schulze-Osthoff; Claus Belka; Gernot Stuhler; Sebastian Wesselborg
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
Cell 2003;113(6):717-30.
2003: Stephan F Schlosser; Markus Schuler; Christoph P Berg; Kirsten Lauber; Klaus Schulze-Osthoff; Friedrich Wilhelm Schmahl; Sebastian Wesselborg
Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells.
Antimicrobial agents and chemotherapy 2003;47(6):1912-21.
2003: Clarissa von Haefen; Thomas Wieder; Frank Essmann; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop.
Oncogene 2003;22(15):2236-47.
2003: Martin Zeller; Frank Essmann; Reiner U Jänicke; Klaus Schulze-Osthoff; Simone Koenig
A rapid nonradioactive peptide phosphorylation assay.
Journal of experimental therapeutics & oncology 2003;3(2):59-61.
2003: Christoph P Berg; Andreas Rothbart; Kirsten Lauber; Gerburg M Stein; Ingo H Engels; Claus Belka; Reiner U Jänicke; Klaus Schulze-Osthoff; Sebastian Wesselborg
Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets.
Oncogene 2003;22(5):775-80.
2003: Peter Daniel; Klaus Schulze-Osthoff; Claus Belka; Dilek Güner
Guardians of cell death: the Bcl-2 family proteins.
Essays in biochemistry 2003;39():73-88.
2003: Heike Bantel; Klaus Schulze-Osthoff
Apoptosis in hepatitis C virus infection.
Cell death and differentiation 2003;10 Suppl 1():S48-58.
2003: Ute Fischer; Reiner U Jänicke; Klaus Schulze-Osthoff
Many cuts to ruin: a comprehensive update of caspase substrates.
Cell death and differentiation 2003;10(1):76-100.
2002: Heike Bantel; M Lienhard Schmitz; Armin Raible; Michael Gregor; Klaus Schulze-Osthoff
Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1832-4.
2002: Christopher Stroh; Uwe Cassens; Ajoy K Samraj; Walter Sibrowski; Klaus Schulze-Osthoff; Marek Los
The role of caspases in cryoinjury: caspase inhibition strongly improves the recovery of cryopreserved hematopoietic and other cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1651-3.
2002: Michael Bitzer; Sorin Armeanu; Florian Prinz; Guy Ungerechts; Wolfgang A Wybranietz; Martin Spiegel; Christian Bernlöhr; Francesco Cecconi; Michael Gregor; Wolfgang J Neubert; Klaus Schulze-Osthoff; Ulrich M Lauer
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.
The Journal of biological chemistry 2002;277(33):29817-24.
2002: Katerina Chlichlia; Marek Los; Klaus Schulze-Osthoff; Louis Gazzolo; Volker Schirrmacher; Khashayarsha Khazaie
Redox events in HTLV-1 Tax-induced apoptotic T-cell death.
Antioxidants & redox signaling 2002;4(3):471-7.
2002: Bernhard R Brehm; Sabine C Wolf; Jens Freudenberg; Folkert Friedmann; Helmut Heinle; Klaus Schulze-Osthoff
Modulation of the beta-adrenergic receptor system of vascular smooth muscle cells in vitro and in vivo by chronically elevated endothelin-1 levels.
Biochemical pharmacology 2002;63(7):1361-9.
2002: Marek Los; Malgorzata Mozoluk; Davide Ferrari; Anna Stepczynska; Christopher Stroh; Andrea Renz; Zdenko Herceg; Zhao-Qi Wang; Klaus Schulze-Osthoff
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.
Molecular biology of the cell 2002;13(3):978-88.
2002: Victoria M Shpacovitch; Thomas Brzoska; Jörg Buddenkotte; Christopher Stroh; Christian P Sommerhoff; John C Ansel; Klaus Schulze-Osthoff; Nigel W Bunnett; Thomas A Luger; Martin Steinhoff
Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells.
The Journal of investigative dermatology 2002;118(2):380-5.
2001: Christoph P Berg; Ingo H Engels; A Rothbart; Kirsten Lauber; A Renz; Stephan F Schlosser; Klaus Schulze-Osthoff; Sebastian Wesselborg
Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis.
Cell death and differentiation 2001;8(12):1197-206.
2001: Justine Rudner; Albrecht Lepple-Wienhues; Wilfried Budach; J Berschauer; B Friedrich; Sebastian Wesselborg; Klaus Schulze-Osthoff; Claus Belka
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis.
Journal of cell science 2001;114(Pt 23):4161-72.
2001: Heike Bantel; Bhanu Sinha; Wolfram Domschke; Georg Peters; Klaus Schulze-Osthoff; Reiner U Jänicke
alpha-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling.
The Journal of cell biology 2001;155(4):637-48.
2001: Thomas Wieder; A Prokop; B Bagci; Frank Essmann; D Bernicke; Klaus Schulze-Osthoff; Bernd Dörken; Hans-Günther Schmalz; Peter Daniel; Günter Henze
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts.
Leukemia 2001;15(11):1735-42.
2001: Craig Marc Luetjens; Donat Kögel; Claus Reimertz; Heiko Düssmann; Andrea Renz; Klaus Schulze-Osthoff; Anna-Liisa Nieminen; Monika Poppe; Jochen H M Prehn
Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.
Molecular pharmacology 2001;60(5):1008-19.
2001: Christof J Burek; J Roth; H G Koch; Klaus Harzer; Marek Los; Klaus Schulze-Osthoff
The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells.
Oncogene 2001;20(45):6493-502.
2001: Heike Bantel; Andreas Lügering; Christopher Poremba; Norbert Lügering; J Held; Wolfram Domschke; Klaus Schulze-Osthoff
Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2001;34(4 Pt 1):758-67.
2001: Andrea Renz; Wolfgang E Berdel; Michael Kreuter; Claus Belka; Klaus Schulze-Osthoff; Marek Los
Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo.
Blood 2001;98(5):1542-8.
2001: Johannes Roth; Matthias Goebeler; S Ludwig; L Wagner; K Kilian; Clemens Sorg; E Harms; Klaus Schulze-Osthoff; H Koch
Homocysteine inhibits tumor necrosis factor-induced activation of endothelium via modulation of nuclear factor-kappa b activity.
Biochimica et biophysica acta 2001;1540(2):154-65.
2001: Reiner U Jänicke; Ingo H Engels; T Dunkern; B Kaina; Klaus Schulze-Osthoff; AG Porter
Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells.
Oncogene 2001;20(36):5043-53.
2001: Kirsten Lauber; H A Appel; Stephan F Schlosser; Michael Gregor; Klaus Schulze-Osthoff; Sebastian Wesselborg
The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.
The Journal of biological chemistry 2001;276(32):29772-81.
2001: J Held; Klaus Schulze-Osthoff
Potential and caveats of TRAIL in cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(4):243-52.
2001: Peter Daniel; Thomas Wieder; Isrid Sturm; Klaus Schulze-Osthoff
The kiss of death: promises and failures of death receptors and ligands in cancer therapy.
Leukemia 2001;15(7):1022-32.
2001: K Friedrich; Thomas Wieder; Clarissa von Haefen; Silke Radetzki; Reiner U Jänicke; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance.
Oncogene 2001;20(22):2749-60.
2001: Claus Belka; B Schmid; Patrizia Marini; E Durand; Justine Rudner; Heidrun Faltin; D D; Klaus Schulze-Osthoff; Wilfried Budach
Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL.
Oncogene 2001;20(17):2190-6.
2001: Anna Stepczynska; Kirsten Lauber; Ingo H Engels; Ottmar Janssen; D Kabelitz; Sebastian Wesselborg; Klaus Schulze-Osthoff
Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Oncogene 2001;20(10):1193-202.
2001: Heike Bantel; P Ruck; Michael Gregor; Klaus Schulze-Osthoff
Detection of elevated caspase activation and early apoptosis in liver diseases.
European journal of cell biology 2001;80(3):230-9.
2001: Thomas Wieder; Frank Essmann; A Prokop; Karin Schmelz; Klaus Schulze-Osthoff; Rudi Beyaert; Bernd Dörken; Peter Daniel
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Blood 2001;97(5):1378-87.
2001: Bernhard R Brehm; Sabine C Wolf; D Bertsch; Martina Klaussner; Sebastian Wesselborg; S Schüler; Klaus Schulze-Osthoff
Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells.
Cardiovascular research 2001;49(2):430-9.
2001: Michael Schmidt; Norbert Lügering; Andreas Lügering; Hans-Gerd Pauels; Klaus Schulze-Osthoff; Wolfram Domschke; Torsten Kucharzik
Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1344-51.
2001: Andrea Renz; Christof J Burek; W Mier; Malgorzata Mozoluk; Klaus Schulze-Osthoff; Marek Los
Cytochrome c is rapidly extruded from apoptotic cells and detectable in serum of anticancer-drug treated tumor patients.
Advances in experimental medicine and biology 2001;495():331-4.
2001: Marek Los; Christopher Stroh; Reiner U Jänicke; Ingo H Engels; Klaus Schulze-Osthoff
Caspases: more than just killers?
Trends in immunology 2001;22(1):31-4.
2001: Bernhard R Brehm; C Bock; Sebastian Wesselborg; S Pfeiffer; S Schüler; Klaus Schulze-Osthoff
Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan.
Biochemical pharmacology 2001;61(1):119-27.
2000: Heike Bantel; C Berg; M Vieth; M Stolte; W Kruis; Klaus Schulze-Osthoff
Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis.
The American journal of gastroenterology 2000;95(12):3452-7.
2000: Steffen P Hehner; Raoul Breitkreutz; G Shubinsky; H Unsoeld; Klaus Schulze-Osthoff; M Lienhard Schmitz; Wulf Dröge
Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4319-28.
2000: Ingo H Engels; Anna Stepczynska; Christopher Stroh; Kirsten Lauber; C Berg; Ralph Schwenzer; Harald Wajant; Reiner U Jänicke; AG Porter; Claus Belka; Michael Gregor; Klaus Schulze-Osthoff; Sebastian Wesselborg
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
Oncogene 2000;19(40):4563-73.
2000: Marek Los; D Neubüser; J F Coy; Malgorzata Mozoluk; A Poustka; Klaus Schulze-Osthoff
Functional characterization of DNase X, a novel endonuclease expressed in muscle cells.
Biochemistry 2000;39(25):7365-73.
2000: Michael Schmidt; Norbert Lügering; Hans-Gerd Pauels; Klaus Schulze-Osthoff; Wolfram Domschke; Torsten Kucharzik
IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway.
European journal of immunology 2000;30(6):1769-77.
2000: Heike Bantel; P Ruck; Klaus Schulze-Osthoff
In situ monitoring of caspase activation in hepatobiliary diseases.
Cell death and differentiation 2000;7(5):504-5.
2000: Claus Belka; Justine Rudner; Sebastian Wesselborg; Anna Stepczynska; Patrizia Marini; Albrecht Lepple-Wienhues; Heidrun Faltin; D D; Wilfried Budach; Klaus Schulze-Osthoff
Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis.
Oncogene 2000;19(9):1181-90.
2000: Sebastian Stier; Gudrun Totzke; Elisabeth Grünewald; Thomas Neuhaus; Stefan Fronhoffs; Agapios Sachinidis; Hans Vetter; Klaus Schulze-Osthoff; Yon Ko
Identification of syntenin and other TNF-inducible genes in human umbilical arterial endothelial cells by suppression subtractive hybridization.
FEBS letters 2000;467(2-3):299-304.
1999: Claus Belka; Vanessa Heinrich; Patrizia Marini; Heidrun Faltin; Klaus Schulze-Osthoff; D D; Wilfried Budach
Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells.
International journal of radiation biology 1999;75(10):1257-64.
1999: Claus Belka; Patrizia Marini; Albrecht Lepple-Wienhues; Wilfried Budach; andreas jekle; Marek Los; Florian Lang; Klaus Schulze-Osthoff; Erich Gulbins; D D
The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.
Oncogene 1999;18(35):4983-92.
1999: Bernd L Fiebich; T J Hofer; Klaus Lieb; Michael Huell; R D Butcher; G Schumann; Klaus Schulze-Osthoff; J Bauer
The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha.
Neuropharmacology 1999;38(9):1325-33.
1999: D Ferrari; C Stroh; Klaus Schulze-Osthoff
P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells.
The Journal of biological chemistry 1999;274(19):13205-10.
1999: Heike Bantel; Ingo H Engels; Wolfgang Voelter; Klaus Schulze-Osthoff; Sebastian Wesselborg
Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis.
Cancer research 1999;59(9):2083-90.
1999: Sebastian Wesselborg; Ingo H Engels; E Rossmann; Marek Los; Klaus Schulze-Osthoff
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.
Blood 1999;93(9):3053-63.
1999: D Ferrari; Marek Los; MK Bauer; P Vandenabeele; Sebastian Wesselborg; Klaus Schulze-Osthoff
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death.
FEBS letters 1999;447(1):71-5.
1999: Kristina Riehemann; B Behnke; Klaus Schulze-Osthoff
Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB.
FEBS letters 1999;442(1):89-94.
1999: Michael Bitzer; Florian Prinz; M Bauer; Martin Spiegel; Wolfgang J Neubert; Michael Gregor; Klaus Schulze-Osthoff; Ulrich M Lauer
Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32).
Journal of virology 1999;73(1):702-8.
1998: C Stroh; Klaus Schulze-Osthoff
Death by a thousand cuts: an ever increasing list of caspase substrates.
Cell death and differentiation 1998;5(12):997-1000.
1998: Heike Bantel; T Brüning; Klaus Schulze-Osthoff
Activation of caspases by death receptors.
European cytokine network 1998;9(4):681-4.
1998: Marek Los; Khashayarsha Khazaie; Klaus Schulze-Osthoff; P A Baeuerle; Volker Schirrmacher; Katerina Chlichlia
Human T cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3050-5.
1998: D Ferrari; Anna Stepczynska; Marek Los; Sebastian Wesselborg; Klaus Schulze-Osthoff
Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis.
The Journal of experimental medicine 1998;188(5):979-84.
1998: Klaus Schulze-Osthoff; D Ferrari; Marek Los; Sebastian Wesselborg; M E Peter
Apoptosis signaling by death receptors.
European journal of biochemistry / FEBS 1998;254(3):439-59.
1998: M Vogt; MK Bauer; D Ferrari; Klaus Schulze-Osthoff
Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells.
FEBS letters 1998;429(1):67-72.
1998: Claus Belka; Patrizia Marini; Wilfried Budach; Klaus Schulze-Osthoff; F Lang; Erich Gulbins; D D
Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand.
Radiation research 1998;149(6):588-95.
1998: MK Bauer; M Vogt; Marek Los; J Siegel; Sebastian Wesselborg; Klaus Schulze-Osthoff
Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression.
The Journal of biological chemistry 1998;273(14):8048-55.
1998: Steffen P Hehner; M Heinrich; P M Bork; M Vogt; F Ratter; Volker Lehmann; Klaus Schulze-Osthoff; Wulf Dröge; M Lienhard Schmitz
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.
The Journal of biological chemistry 1998;273(3):1288-97.
1997: D Ferrari; Sebastian Wesselborg; MK Bauer; Klaus Schulze-Osthoff
Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65.
The Journal of cell biology 1997;139(7):1635-43.
1997: Klaus Lieb; Bernd L Fiebich; Mathias Berger; J Bauer; Klaus Schulze-Osthoff
The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4952-8.
1997: Sebastian Wesselborg; MK Bauer; M Vogt; M Lienhard Schmitz; Klaus Schulze-Osthoff
Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.
The Journal of biological chemistry 1997;272(19):12422-9.
1997: MK Bauer; Sebastian Wesselborg; Klaus Schulze-Osthoff
The Caenorhabditis elegans death protein Ced-4 contains a motif with similarity to the mammalian 'death effector domain'.
FEBS letters 1997;402(2-3):256-8.
1997: MK Bauer; K Lieb; Klaus Schulze-Osthoff; M Berger; Peter J Gebicke-Haerter; J Bauer; B L Fiebich
Expression and regulation of cyclooxygenase-2 in rat microglia.
European journal of biochemistry / FEBS 1997;243(3):726-31.
1997: Klaus Schulze-Osthoff; MK Bauer; M Vogt; Sebastian Wesselborg
Oxidative stress and signal transduction.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1997;67(5):336-42.
1996: F Ratter; Matthias Germer; T Fischbach; Klaus Schulze-Osthoff; Marcus E Peter; Wulf Dröge; Peter H Krammer; Volker Lehmann
S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.
International immunology 1996;8(7):1139-47.
1996: S Grimm; MK Bauer; PA Baeuerle; Klaus Schulze-Osthoff
Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.
The Journal of cell biology 1996;134(1):13-23.
1996: Klaus Schulze-Osthoff; MK Bauer; M Vogt; Marek Los
Role of ICE-related and other proteases in Fas-mediated apoptosis.
Cell death and differentiation 1996;3(2):177-84.
1996: Heike L Pahl; B Krauss; Klaus Schulze-Osthoff; T Decker; E B Traenckner; M Vogt; C Myers; T Parks; P Warring; A Mühlbacher; A P Czernilofsky; PA Baeuerle
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.
The Journal of experimental medicine 1996;183(4):1829-40.
1996: H Schenk; M Vogt; Wulf Dröge; Klaus Schulze-Osthoff
Thioredoxin as a potent costimulus of cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):765-71.
1995: Klaus Schulze-Osthoff; Marek Los; PA Baeuerle
Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes.
Biochemical pharmacology 1995;50(6):735-41.
1995: Marek Los; H Schenk; K Hexel; PA Baeuerle; Wulf Dröge; Klaus Schulze-Osthoff
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
The EMBO journal 1995;14(15):3731-40.
1995: Marek Los; M Van de Craen; Louis C Penning; H Schenk; M Westendorp; PA Baeuerle; Wulf Dröge; Peter H Krammer; Walter Fiers; Klaus Schulze-Osthoff
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.
Nature 1995;375(6526):81-3.
1995: M O Westendorp; Vladimir Shatrov; Klaus Schulze-Osthoff; R Frank; M Kraft; Marek Los; Peter H Krammer; Wulf Dröge; Volker Lehmann
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
The EMBO journal 1995;14(3):546-54.
1995: Marek Los; Wulf Dröge; K Stricker; PA Baeuerle; Klaus Schulze-Osthoff
Hydrogen peroxide as a potent activator of T lymphocyte functions.
European journal of immunology 1995;25(1):159-65.
1995: Klaus Schulze-Osthoff; H Schenk; Wulf Dröge
Effects of thioredoxin on activation of transcription factor NF-kappa B.
Methods in enzymology 1995;252():253-64.
1994: Wulf Dröge; Klaus Schulze-Osthoff; S Mihm; D Galter; H Schenk; H P Eck; S Roth; H Gmünder
Functions of glutathione and glutathione disulfide in immunology and immunopathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(14):1131-8.
1994: Klaus Schulze-Osthoff; Peter H Krammer; Wulf Dröge
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.
The EMBO journal 1994;13(19):4587-96.
1994: Klaus Schulze-Osthoff; Henning Walczak; Wulf Dröge; Peter H Krammer
Cell nucleus and DNA fragmentation are not required for apoptosis.
The Journal of cell biology 1994;127(1):15-20.
1994: Marek Los; Wulf Dröge; Klaus Schulze-Osthoff
Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.
The Biochemical journal 1994;302 ( Pt 1)():119-23.
1994: S Bergmann; Vladimir Shatrov; F Ratter; S Schiemann; Klaus Schulze-Osthoff; Volker Lehmann
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1736-43.
1994: H Schenk; M Klein; Wilhelm Erdbrügger; Wulf Dröge; Klaus Schulze-Osthoff
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1672-6.