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Frédéric Blanchard

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Emmanuelle David; Olivier Delattre; Pierre Guihard; Dominique Heymann; Marie F Heymann; Karine Laud; Françoise Redini; Franck Tirode; Marc Baud'huin; Frédéric Blanchard
Oncostatin M is a growth factor for Ewing sarcoma.
Pierre Guihard; Dominique Heymann; Françoise Rédini; Carl D Richards; Régis Brion; Bénédicte Brounais; Sylvie Chevalier; Yannic Danger; Emmanuelle David; Joël Delecrin; Hugues Gascan; Frédéric Blanchard
Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling.
M Chemel; C Cozic; J Amiaud; Martine Berreur; Jean-Marie Berthelot; Frédéric Blanchard; G Bougras; R Brion; M F Heymann; Benoît Le Goff; S Touchais; F Verrecchia; Dominique Heymann
Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients.

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All Publications

2012: Emmanuelle David; Olivier Delattre; Pierre Guihard; Dominique Heymann; Marie F Heymann; Karine Laud; Françoise Redini; Franck Tirode; Marc Baud'huin; Frédéric Blanchard
Oncostatin M is a growth factor for Ewing sarcoma.
The American journal of pathology 2012;181(5):1782-95.
2012: Pierre Guihard; Dominique Heymann; Françoise Rédini; Carl D Richards; Régis Brion; Bénédicte Brounais; Sylvie Chevalier; Yannic Danger; Emmanuelle David; Joël Delecrin; Hugues Gascan; Frédéric Blanchard
Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling.
Stem cells (Dayton, Ohio) 2012;30(4):762-72.
2012: M Chemel; C Cozic; J Amiaud; Martine Berreur; Jean-Marie Berthelot; Frédéric Blanchard; G Bougras; R Brion; M F Heymann; Benoît Le Goff; S Touchais; F Verrecchia; Dominique Heymann
Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients.
Annals of the rheumatic diseases 2012;71(1):150-4.
2011: Emmanuelle David; Pierre Guihard; Bénédicte Brounais; Anne Riet; Céline Charrier; Séverine Battaglia; François Gouin; Stéphanie Ponsolle; Ronan Le Bot; Carl D Richards; Dominique Heymann; Françoise Rédini; Frédéric Blanchard
Direct anti-cancer effect of oncostatin M on chondrosarcoma.
International journal of cancer. Journal international du cancer 2011;128(8):1822-35.
2009: Bénédicte Brounais; Emmanuelle David; Céline Chipoy; Valérie Trichet; Virginie Ferré; Céline Charrier; Laurence Duplomb; Martine Berreur; Françoise Rédini; Dominique Heymann; Frédéric Blanchard
Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells.
Bone 2009;44(5):830-9.
2009: Frédéric Blanchard; Laurence Duplomb; Marc Baud'huin; Bénédicte Brounais
The dual role of IL-6-type cytokines on bone remodeling and bone tumors.
Cytokine & growth factor reviews 2009;20(1):19-28.
2008: Kanji Mori; Frédéric Blanchard; Celine Charrier; Severine Battaglia; Kosei Ando; Laurence Duplomb; Leonard D Shultz; Francoise Redini; Dominique Heymann
Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk.
Cancer science 2008;99(11):2170-6.
2008: Bénédicte Brounais; Céline Chipoy; Kanji Mori; Céline Charrier; Séverine Battaglia; Paul Pilet; Carl D Richards; Dominique Heymann; Françoise Rédini; Frédéric Blanchard
Oncostatin M induces bone loss and sensitizes rat osteosarcoma to the antitumor effect of Midostaurin in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5400-9.
2008: Laurence Duplomb; Marc Baud'huin; Céline Charrier; Martine Berreur; Valérie Trichet; Frédéric Blanchard; Dominique Heymann
Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.
Endocrinology 2008;149(7):3688-97.
2007: Kanji Mori; Martine Berreur; Frédéric Blanchard; Catherine Chevalier; Isabelle Guisle-Marsollier; Martial Masson; Françoise Rédini; Dominique Heymann
Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells.
Oncology reports 2007;18(6):1365-71.
2007: Céline Chipoy; B Brounais; Valérie Trichet; Séverine Battaglia; Martine Berreur; Lisa Oliver; Philippe Juin; Françoise Rédini; Dominique Heymann; Frédéric Blanchard
Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53.
Oncogene 2007;26(46):6653-64.
2007: François Lamoureux; Peggy Richard; Yohann Wittrant; Séverine Battaglia; Paul Pilet; Valérie Trichet; Frédéric Blanchard; François Gouin; Bruno Pitard; Dominique Heymann; Françoise Redini
Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption.
Cancer research 2007;67(15):7308-18.
2007: Kanji Mori; Benoît Le Goff; Martine Berreur; Anne Riet; A Moreau; Frédéric Blanchard; C Chevalier; Isabelle Guisle-Marsollier; J Léger; Jérôme Guicheux; M Masson; François Gouin; Françoise Rédini; Dominique Heymann
Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B.
The Journal of pathology 2007;211(5):555-62.
2007: A Lacreusette; Jean-Michel Nguyen; Marie-Christine Pandolfino; Amir Khammari; Brigitte Dreno; Yannick Jacques; Anne Godard; Frédéric Blanchard
Loss of oncostatin M receptor beta in metastatic melanoma cells.
Oncogene 2007;26(6):881-92.
2007: François Lamoureux; Valérie Trichet; Céline Chipoy; Frédéric Blanchard; François Gouin; Françoise Redini
Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies.
Expert review of anticancer therapy 2007;7(2):169-81.
2007: Benjamin Ory; Frédéric Blanchard; Séverine Battaglia; François Gouin; Françoise Rédini; Dominique Heymann
Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status.
Molecular pharmacology 2007;71(1):333-43.
2006: Sandrine Théoleyre; S Kwan Tat; Patricia Vusio; Frédéric Blanchard; J Gallagher; S Ricard-Blum; Yannick Fortun; Marc Padrines; Françoise Rédini; Dominique Heymann
Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance: role in the interactions with receptor activator of nuclear factor kappaB ligand (RANKL) and RANK.
Biochemical and biophysical research communications 2006;347(2):460-7.
2005: Dominique Heymann; Benjamin Ory; Frédéric Blanchard; Marie-Françoise Heymann; Patrick Coipeau; Céline Charrier; Séverine Couillaud; JEAN PAUL THIERY; François Gouin; Françoise Redini
Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma.
Bone 2005;37(1):74-86.
2005: Frédéric Blanchard; Céline Chipoy
Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?
Drug discovery today 2005;10(3):197-204.
2005: Gregory M Loewen; Erin Tracy; Frédéric Blanchard; Dongfeng Tan; Jihnhee Yu; Sameera Raza; Sei-Ichi Matsui; Heinz Baumann
Transformation of human bronchial epithelial cells alters responsiveness to inflammatory cytokines.
BMC cancer 2005;5():145.
2004: Céline Chipoy; Martine Berreur; Séverine Couillaud; Gilbert Pradal; François M Vallette; Caroline Colombeix; Françoise Rédini; Dominique Heymann; Frédéric Blanchard
Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(11):1850-61.
2004: Yohann Wittrant; Sandrine Théoleyre; Céline Chipoy; Marc Padrines; Frédéric Blanchard; Dominique Heymann; Françoise Rédini
RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis.
Biochimica et biophysica acta 2004;1704(2):49-57.
2004: Sandrine Theoleyre; Yohann Wittrant; Séverine Couillaud; Patricia Vusio; Martine Berreur; C Dunstan; Frédéric Blanchard; Françoise Rédini; Dominique Heymann
Cellular activity and signaling induced by osteoprotegerin in osteoclasts: involvement of receptor activator of nuclear factor kappaB ligand and MAPK.
Biochimica et biophysica acta 2004;1644(1):1-7.
2003: Frédéric Blanchard; Erin Tracy; Joseph Smith; Souvik Chattopadhyay; Yanping Wang; Werner Held; Heinz Baumann
DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor.
Hepatology (Baltimore, Md.) 2003;38(6):1516-28.
2003: Laurence Duplomb; Benjamin Chaigne-Delalande; Patricia Vusio; Sylvie Raher; Yannick Jacques; Anne Godard; Frédéric Blanchard
Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II.
Endocrinology 2003;144(12):5381-9.
2003: Juliette Bitard; Sophie Daburon; Laurence Duplomb; Frédéric Blanchard; Patricia Vuisio; Yannick Jacques; Anne Godard; John Heath; Jean-François Moreau; Jean-Luc Taupin
Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF.
The Journal of biological chemistry 2003;278(18):16253-61.
2002: Eva Grimaud; Frédéric Blanchard; Céline Charrier; François Gouin; Françoise Redini; Dominique Heymann
Leukaemia inhibitory factor (lif) is expressed in hypertrophic chondrocytes and vascular sprouts during osteogenesis.
Cytokine 2002;20(5):224-30.
2002: Frédéric Blanchard; Erin Kinzie; Yanping Wang; Laurence Duplomb; Anne Godard; Werner Held; Bonnie B Asch; Heinz Baumann
FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins.
Oncogene 2002;21(41):6264-77.
2002: William C Burhans; Frédéric Blanchard; H Baumann
Origin licensing and programmed cell death: a hypothesis.
Cell death and differentiation 2002;9(9):870-2.
2002: Frédéric Blanchard; Michael E Rusiniak; Karuna Sharma; Xiaolei Sun; Ivan Todorov; M Mar Castellano; Crisanto Gutierrez; Heinz Baumann; William C Burhans
Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast.
Molecular biology of the cell 2002;13(5):1536-49.
2001: Jean-Luc Taupin; Patrick Legembre; Juliette Bitard; Sophie Daburon; Vincent Pitard; Frédéric Blanchard; Laurence Duplomb; Anne Godard; Yannick Jacques; Jean-François Moreau
Identification of agonistic and antagonistic antibodies against gp190, the leukemia inhibitory factor receptor, reveals distinct roles for its two cytokine-binding domains.
The Journal of biological chemistry 2001;276(51):47975-81.
2001: Frédéric Blanchard; Yong Wang; Erin Kinzie; Laurence Duplomb; Anne Godard; Heinz Baumann
Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms.
The Journal of biological chemistry 2001;276(50):47038-45.
2000: Frédéric Blanchard; Laurence Duplomb; Yong Wang; O Robledo; Erin Kinzie; Vincent Pitard; Anne Godard; Yannick Jacques; Heinz Baumann
Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase.
The Journal of biological chemistry 2000;275(37):28793-801.
2000: Yong Wang; O Robledo; Erin Kinzie; Frédéric Blanchard; C Richards; A Miyajima; Heinz Baumann
Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor.
The Journal of biological chemistry 2000;275(33):25273-85.
1999: Frédéric Blanchard; Laurence Duplomb; Sylvie Raher; Patricia Vusio; B Hoflack; Yannick Jacques; Anne Godard
Mannose 6-Phosphate/Insulin-like growth factor II receptor mediates internalization and degradation of leukemia inhibitory factor but not signal transduction.
The Journal of biological chemistry 1999;274(35):24685-93.
1999: Jean-Luc Taupin; Véronique Miossec; Vincent Pitard; Frédéric Blanchard; Sophie Daburon; Sylvie Raher; Yannick Jacques; Anne Godard; Jean-François Moreau
Binding of leukemia inhibitory factor (LIF) to mutants of its low affinity receptor, gp190, reveals a LIF binding site outside and interactions between the two cytokine binding domains.
The Journal of biological chemistry 1999;274(20):14482-9.
1998: Frédéric Blanchard; Sylvie Raher; Laurence Duplomb; Patricia Vusio; Vincent Pitard; Jean-Luc Taupin; Jean-François Moreau; B Hoflack; Stéphane Minvielle; Yannick Jacques; Anne Godard
The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor.
The Journal of biological chemistry 1998;273(33):20886-93.
1997: Frédéric Blanchard; Vincent Pitard; Jean-Luc Taupin; Sylvie Raher; Marie-Martine Hallet; Jean-François Moreau; Anne Godard; Yannick Jacques
Epitope-function relationships of human leukemia inhibitory factor receptors using a novel set of anti-gp190 mAB.
International immunology 1997;9(12):1775-84.
1997: Vincent Pitard; Jean-Luc Taupin; Véronique Miossec; Frédéric Blanchard; M Cransac; I Jollet; AB Vernallis; K Hudson; Anne Godard; Yannick Jacques; Jean-François Moreau
Production and characterization of monoclonal antibodies against the leukemia inhibitory factor low affinity receptor, gp190.
Journal of immunological methods 1997;205(2):177-90.
1997: François Davodeau; Marie-Alix Peyrat; A Necker; R Dominici; Frédéric Blanchard; C Leget; J Gaschet; P Costa; Yannick Jacques; Anne Godard; H Vie; Alessandro Poggi; François Romagné; Marc Bonneville
Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpha-chains.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5603-11.
1996: Dominique Heymann; Anne Godard; Sylvie Raher; N Bentouimou; Frédéric Blanchard; M Cherel; Marie-Martine Hallet; Yannick Jacques
Leukemia inhibitory factor (LIF) and oncastsin M (OSM) high affinity binding require additional receptor subunits besides GP130 and GP190.
Cytokine 1996;8(3):197-205.
1996: Dominique Heymann; Jean Harb; S Ringeard; Frédéric Blanchard; D Lassort; Sylvie Raher; Anne Godard
[Modulation of integrin alpha-v-beta-1 expression on human tumor cells by leukemia inhibitory factor (LIF) and oncostatin M (OSM)].
Bulletin du cancer 1996;83(1):13-21.
1995: Dominique Heymann; Jean Harb; S Ringeard; Frédéric Blanchard; D Lassort; Sylvie Raher; Anne Godard
Upmodulation of alpha v beta 1 integrin expression on human tumor cells by human interleukin for DA cells/leukemia inhibitory factor and oncostatin M: correlation with increased cell adhesion on fibronectin.
Journal of cellular biochemistry 1995;58(3):305-14.
1995: Dominique Heymann; Frédéric Blanchard; Sylvie Raher; DD De Groote; Anne Godard
Modulation of LIF expression in human melanoma cells by oncostatin M.
Immunology letters 1995;46(3):245-51.
1995: Dominique Heymann; Anne Godard; Sylvie Raher; S Ringeard; D Lassort; Frédéric Blanchard; Jean Harb
Human interleukin for DA cells/leukemia inhibitory factor and oncostatin M enhance membrane expression of intercellular adhesion molecule-1 on melanoma cells but not the shedding of its soluble form.
Cytokine 1995;7(2):111-7.