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Paul Schumacker

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Stephen Wedgwood; Lyubov Czech; Satyan Lakshminrusimha; Paul T Schumacker; Robin Steinhorn
Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn.
D James Surmeier; Paul T Schumacker
Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease.
Jacqueline M Schriewer; Joseph Bass; Clara Bien Peek; Paul T Schumacker
ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion.

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All Publications

2013: Stephen Wedgwood; Lyubov Czech; Satyan Lakshminrusimha; Paul T Schumacker; Robin Steinhorn
Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn.
Antioxidants & redox signaling 2013;18(14):1765-76.
2013: D James Surmeier; Paul T Schumacker
Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease.
The Journal of biological chemistry 2013;288(15):10736-41.
2013: Jacqueline M Schriewer; Joseph Bass; Clara Bien Peek; Paul T Schumacker
ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion.
Journal of the American Heart Association 2013;2(2):e000159.
2013: Laura A Sena; Chyung-Ru Wang; Paul J Bryce; Teresa Ezponda; David A Hildeman; Amit Jairaman; Sha Li; Jonathan D Licht; Harris Perlman; Murali Prakriya; Paul T Schumacker; Navdeep S Chandel
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.
Immunity 2013;38(2):225-36.
2013: Gregory B Waypa; Molly K Ball; Danijela Dokic; Robert D Guzy; Jeremy D Marks; Paul T Mungai; Jacqueline M Schriewer; Paul T Schumacker
Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.
American journal of respiratory and critical care medicine 2013;187(4):424-32.
2013: Monica R Shah; Robin H Steinhorn; Stephen Wedgwood; Lyubov Czech; Gina A Kim; Satyan Lakshminrusimha; Paul T Schumacker; Kathryn N Farrow
Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells.
International journal of molecular sciences 2013;14(2):4334-48.
2012: Kathryn N Farrow; Satyan Lakshminrusimha; Keng Jin Lee; Marta Perez; Jacqueline M Schriewer; Cody L Smith; Robin Steinhorn; Stephen Wedgwood; Paul T Schumacker
Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells.
Antioxidants & redox signaling 2012;17(3):460-70.
2012: D James Surmeier; Jaime N Guzman; Javier Sanchez; Paul T Schumacker
Physiological phenotype and vulnerability in Parkinson's disease.
Cold Spring Harbor perspectives in medicine 2012;2(7):a009290.
2012: Wenjian Wang; Yin Wang; Benny H J Chang; Sandra B Haudek; Jianyin Long; Paul Overbeek; Paul T Schumacker; Jinrong Wang; Farhad R Danesh
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells.
Cell metabolism 2012;15(2):186-200.
2011: Dalton Surmeier; Jaime N Guzman; J Sanchez-Padilla; Paul T Schumacker
The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease.
Neuroscience 2011;198():221-31.
2011: Paul T Schumacker
Lung cell hypoxia: role of mitochondrial reactive oxygen species signaling in triggering responses.
Proceedings of the American Thoracic Society 2011;8(6):477-84.
2011: Stephen Wedgwood; Tohru Fukai; Satyan Lakshminrusimha; James A Russell; Paul T Schumacker; Robin Steinhorn
Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension.
Antioxidants & redox signaling 2011;15(6):1497-506.
2011: Paul T Mungai; Murali Prakriya; Molly K Ball; Danijela Dokic; Amit Jairaman; Gregory B Waypa; Paul T Schumacker
Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
Molecular and cellular biology 2011;31(17):3531-45.
2011: Gabriel Loor; Jyothisri Kondapalli; Hirotaro Iwase; Navdeep S Chandel; Gregory B Waypa; Robert D Guzy; Terry Vanden Hoek; Paul T Schumacker
Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion.
Biochimica et biophysica acta 2011;1813(7):1382-94.
2011: G R Scott Budinger; Gökhan M Mutlu; Daniela Urich; Saul Soberanes; Leonard J Buccellato; Keenan Hawkins; Sergio E Chiarella; Kathryn A Radigan; James Eisenbart; Hemant Agrawal; Sara Berkelhamer; Siegfried Hekimi; Jianke Zhang; Harris Perlman; Paul T Schumacker; Manu Jain; Navdeep S Chandel
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
American journal of respiratory and critical care medicine 2011;183(8):1043-54.
2011: Michael P Murphy; Arne Holmgren; Nils-Göran Larsson; Barry Halliwell; Christopher J Chang; Balaraman Kalyanaraman; Sue Goo Rhee; Paul J Thornalley; Linda Partridge; David Gems; Thomas Nyström; Vsevolod Belousov; Paul T Schumacker; Christine C Winterbourn
Unraveling the biological roles of reactive oxygen species.
Cell metabolism 2011;13(4):361-6.
2011: Rajit K Basu; Susan Hubchak; Tomoko Hayashida; Constance E Runyan; Paul T Schumacker; H William Schnaper
Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression.
American journal of physiology. Renal physiology 2011;300(4):F898-905.
2011: Paul T Schumacker
SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.
Cancer cell 2011;19(3):299-300.
2010: Paul T Schumacker; Jeremy P T Ward
Physiological redox signaling in lung, cardiovascular and neural cells: progress, controversy and potential.
Respiratory physiology & neurobiology 2010;174(3):163-4.
2010: Kathryn N Farrow; Stephen Wedgwood; Keng Jin Lee; Lyubov Czech; Sylvia F Gugino; Satyan Lakshminrusimha; Paul T Schumacker; Robin Steinhorn
Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn.
Respiratory physiology & neurobiology 2010;174(3):272-81.
2010: Gregory B Waypa; Paul T Schumacker
Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?
Respiratory physiology & neurobiology 2010;174(3):201-11.
2010: Gabriel Loor; Jyothisri Kondapalli; Jacqueline M Schriewer; Navdeep S Chandel; Terry Vanden Hoek; Paul T Schumacker
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis.
Free radical biology & medicine 2010;49(12):1925-36.
2010: Jaime N Guzman; Javier Sanchez-Padilla; David Wokosin; Jyothisri Kondapalli; Ema Ilijic; Paul T Schumacker; Dalton Surmeier
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Nature 2010;468(7324):696-700.
2010: Sangkyu Lee; Yue Chen; Hao Luo; Andrew A Wu; Michael Wilde; Paul T Schumacker; Yingming Zhao
The first global screening of protein substrates bearing protein-bound 3,4-Dihydroxyphenylalanine in Escherichia coli and human mitochondria.
Journal of proteome research 2010;9(11):5705-14.
2010: Hye Jin Jung; Joong Sup Shim; Jiyong Lee; Young Mi Song; Ki Chung Park; Seung Hoon Choi; Nam Doo Kim; Jeong Hyeok Yoon; Paul T Mungai; Paul T Schumacker; Ho Jeong Kwon
Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing.
The Journal of biological chemistry 2010;285(15):11584-95.
2010: Jennifer R Desireddi; Kathryn N Farrow; Jeremy D Marks; Gregory B Waypa; Paul T Schumacker
Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices.
Antioxidants & redox signaling 2010;12(5):595-602.
2010: Annie Y Chi; Gregory B Waypa; Paul T Mungai; Paul T Schumacker
Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells.
Antioxidants & redox signaling 2010;12(5):603-10.
2010: Andrew M Evens; Laurie H Sehn; Pedro Farinha; Beverly P Nelson; Adekunle Raji; Yi Lu; Adam Brakman; Vamsi Parimi; Jane N Winter; Paul T Schumacker; Randy D Gascoyne; Leo I Gordon
Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(6):1017-24.
2010: Gregory B Waypa; Jeremy D Marks; Robert D Guzy; Paul T Mungai; Jacqueline Schriewer; Danijela Dokic; Paul T Schumacker
Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells.
Circulation research 2010;106(3):526-35.
2010: Paul T Schumacker
A tumor suppressor SIRTainty.
Cancer cell 2010;17(1):5-6.
2010: Paul T Schumacker
Is enough oxygen too much?
Critical care (London, England) 2010;14(4):191.
2009: Mala Shanmugam; Samuel K McBrayer; Jun Qian; Kiril Raikoff; Michael J Avram; Seema Singhal; Varsha Gandhi; Paul T Schumacker; Nancy L Krett; Steven T Rosen
Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine.
The Journal of biological chemistry 2009;284(39):26816-30.
2009: Vijayalakshmi Panduri; G Liu; Sailesh Surapureddi; J Kondapalli; Saul Soberanes; N C de Souza-Pinto; V A Bohr; G R Scott Budinger; Paul T Schumacker; Sigmund A Weitzman; David W Kamp
Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis.
Free radical biology & medicine 2009;47(6):750-9.
2009: Tatyana A Klimova; Eric L Bell; Emelyn H Shroff; Frank D Weinberg; Colleen M Snyder; Goberdan P Dimri; Paul T Schumacker; G R Scott Budinger; Navdeep S Chandel
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):783-94.
2009: Saul Soberanes; Daniela Urich; Christina M Baker; Zach Burgess; Sergio E Chiarella; Eric L Bell; Andrew J Ghio; Andrea De Vizcaya-Ruiz; Jing Liu; Karen M Ridge; David W Kamp; Navdeep S Chandel; Paul T Schumacker; Gökhan M Mutlu; G R Scott Budinger
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
The Journal of biological chemistry 2009;284(4):2176-86.
2008: Olesya A Ulanovskaya; Jelena Janjic; Masato Suzuki; Simran S Sabharwal; Paul T Schumacker; Stephen J Kron; Sergey A Kozmin
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
Nature chemical biology 2008;4(7):418-24.
2008: Andrew M Evens; Paul T Schumacker; Irene B Helenowski; Amareshwar T K Singh; Danijela Dokic; Anjeni Keswani; Elizabeth Kordeluk; Adekunle Raji; Jane N Winter; Borko D Jovanovic; Arne Holmgren; Beverly P Nelson; Leo I Gordon
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
British journal of haematology 2008;141(5):676-80.
2008: G Loor; Paul T Schumacker
Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion.
Cell death and differentiation 2008;15(4):686-90.
2008: István Vadász; Laura A Dada; Arturo Briva; Humberto Trejo; Lynn C Welch; Jiwang Chen; Péter T Tóth; Emilia Lecuona; Lee A Witters; Paul T Schumacker; Navdeep S Chandel; Werner Seeger; Jacob I Sznajder
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
The Journal of clinical investigation 2008;118(2):752-62.
2008: Kathryn N Farrow; Beezly S Groh; Paul T Schumacker; Satyan Lakshminrusimha; Lyubov Czech; Sylvia F Gugino; James A Russell; Robin Steinhorn
Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells.
Circulation research 2008;102(2):226-33.
2008: Gregory B Waypa; Paul T Schumacker
Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question.
Experimental physiology 2008;93(1):133-8.
2008: Robert D Guzy; Bhumika Sharma; Eric Bell; Navdeep S Chandel; Paul T Schumacker
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Molecular and cellular biology 2008;28(2):718-31.
2007: Robert D Guzy; Mathew M Mack; Paul T Schumacker
Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast.
Antioxidants & redox signaling 2007;9(9):1317-28.
2007: Kristin Tracy; Benjamin C Dibling; Benjamin T Spike; James R Knabb; Paul T Schumacker; Kay F Macleod
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Molecular and cellular biology 2007;27(17):6229-42.
2007: Hirotaro Iwase; Emmanuel Robin; Robert D Guzy; Paul T Mungai; Terry Vanden Hoek; Navdeep S Chandel; Jacques Levraut; Paul T Schumacker
Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes.
Free radical biology & medicine 2007;43(4):590-9.
2007: Eric L Bell; Tatyana A Klimova; James Eisenbart; Paul T Schumacker; Navdeep S Chandel
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia.
Molecular and cellular biology 2007;27(16):5737-45.
2007: Emmanuel Robin; Robert D Guzy; Gabriel Loor; Hirotaro Iwase; Gregory B Waypa; Jeremy D Marks; Terry Vanden Hoek; Paul T Schumacker
Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion.
The Journal of biological chemistry 2007;282(26):19133-43.
2007: Ram M Subramanian; Navdeep S Chandel; G R Scott Budinger; Paul T Schumacker
Hypoxic conformance of metabolism in primary rat hepatocytes: a model of hepatic hibernation.
Hepatology (Baltimore, Md.) 2007;45(2):455-64.
2006: Gregory B Waypa; Robert D Guzy; Paul T Mungai; Mathew M Mack; Jeremy D Marks; Michael W Roe; Paul T Schumacker
Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells.
Circulation research 2006;99(9):970-8.
2006: Paul T Schumacker
Reactive oxygen species in cancer cells: live by the sword, die by the sword.
Cancer cell 2006;10(3):175-6.
2006: Robert D Guzy; Paul T Schumacker
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.
Experimental physiology 2006;91(5):807-19.
2006: Mir H Ali; Paul T Mungai; Paul T Schumacker
Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants.
American journal of physiology. Lung cellular and molecular physiology 2006;291(1):L38-45.
2006: Zuo-Hui Shao; Chin-Wang Hsu; Wei-Tien Chang; Gregory B Waypa; J Li; D Li; Chang-Qing Li; Travis Anderson; Yimin Qin; Paul T Schumacker; Lance B Becker; Terry Vanden Hoek
Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide.
Cell biology and toxicology 2006;22(3):149-58.
2006: Gregory B Waypa; Paul T Schumacker
Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction.
Novartis Foundation symposium 2006;272():176-92; discussion 192-5, 214-7.
2005: Paul T Schumacker
Hypoxia-inducible factor-1 (HIF-1).
Critical care medicine 2005;33(12 Suppl):S423-5.
2005: Dongdong Li; Jeremy D Marks; Paul T Schumacker; Regina M Young; James R Brorson
Physiological hypoxia promotes survival of cultured cortical neurons.
The European journal of neuroscience 2005;22(6):1319-26.
2005: Robert D Guzy; Beatrice Hoyos; Emmanuel Robin; Hong Chen; Liping Liu; Kyle D Mansfield; M Celeste Simon; Ulrich Hammerling; Paul T Schumacker
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
Cell metabolism 2005;1(6):401-8.
2005: Kyle D Mansfield; Robert D Guzy; Yi Pan; Regina M Young; Timothy P Cash; Paul T Schumacker; M Celeste Simon
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.
Cell metabolism 2005;1(6):393-9.
2005: Gregory B Waypa; Paul T Schumacker
Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):404-14.
2004: Gi Ryang Kweon; Jeremy D Marks; Robert Krencik; Eric H Leung; Paul T Schumacker; Keith Hyland; Un Jung Kang
Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells.
The Journal of biological chemistry 2004;279(50):51783-92.
2004: Mir H Ali; Daryl P Pearlstein; Carol E Mathieu; Paul T Schumacker
Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction.
American journal of physiology. Lung cellular and molecular physiology 2004;287(3):L486-96.
2004: Zuo-Hui Shao; Jing-Tian Xie; Terry Vanden Hoek; Sangeeta R Mehendale; Han H Aung; Chang-Qing Li; Yimin Qin; Paul T Schumacker; Lance B Becker; Chun-Su Yuan
Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress.
Biochimica et biophysica acta 2004;1670(3):165-71.
2004: Zuo-Hui Shao; Terry Vanden Hoek; Chang-Qing Li; Paul T Schumacker; Lance B Becker; Kim Chai Chan; Yimin Qin; Jun-Jie Yin; Chun-Su Yuan
Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro.
The American journal of Chinese medicine 2004;32(1):89-95.
2003: Zuo-Hui Shao; Lance B Becker; Terry Vanden Hoek; Paul T Schumacker; Chang-Qing Li; Danhong Zhao; Kim Wojcik; Travis Anderson; Yimin Qin; Lucy Dey; Chun-Su Yuan
Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(6):463-9.
2003: Jacques Levraut; Hirotaro Iwase; Zuo-Hui Shao; Terry Vanden Hoek; Paul T Schumacker
Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H549-58.
2003: Zuo-Hui Shao; Terry Vanden Hoek; Jingtian Xie; Kim Wojcik; Kim Chai Chan; Chang-Qing Li; Kimm J Hamann; Yimin Qin; Paul T Schumacker; Lance B Becker; Chun-Su Yuan
Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes.
Cardiovascular toxicology 2003;3(4):331-9.
2003: Paul T Schumacker
Current paradigms in cellular oxygen sensing.
Advances in experimental medicine and biology 2003;543():57-71.
2003: Gilles Lebuffe; Paul T Schumacker; Zuo-Hui Shao; Travis Anderson; Hirotoro Iwase; Terry Vanden Hoek
ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H299-308.
2002: Paul T Schumacker
Angiotensin II signaling in the brain: compartmentalization of redox signaling?
Circulation research 2002;91(11):982-4.
2002: Paul T Schumacker
Hypoxia, anoxia, and O2 sensing: the search continues.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L918-21.
2002: Gregory B Waypa; Jeremy D Marks; Mathew M Mack; Chan Boriboun; Paul T Mungai; Paul T Schumacker
Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes.
Circulation research 2002;91(8):719-26.
2002: Gregory B Waypa; Paul T Schumacker
O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens.
Respiratory physiology & neurobiology 2002;132(1):81-91.
2002: Andre Kulisz; Ningfang Chen; Navdeep S Chandel; Zuohui Shao; Paul T Schumacker
Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes.
American journal of physiology. Lung cellular and molecular physiology 2002;282(6):L1324-9.
2002: Mir H Ali; Paul T Schumacker
Endothelial responses to mechanical stress: where is the mechanosensor?
Critical care medicine 2002;30(5 Suppl):S198-206.
2002: Paul T Schumacker
Straining to understand mechanotransduction in the lung.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L881-2.
2002: Daryl P Pearlstein; Mir H Ali; Paul T Mungai; Karen L Hynes; Bruce Gewertz; Paul T Schumacker
Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):566-73.
2002: Zuo-Hui Shao; Terry Vanden Hoek; Yimin Qin; Lance B Becker; Paul T Schumacker; Chang-Qing Li; Lucy Dey; Eugene Barth; Howard J Halpern; Gerald M. Rosen; Chun-Su Yuan
Baicalein attenuates oxidant stress in cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H999-H1006.
2001: Navdeep S Chandel; Paul T Schumacker; RH Arch
Reactive oxygen species are downstream products of TRAF-mediated signal transduction.
The Journal of biological chemistry 2001;276(46):42728-36.
2001: Gregory B Waypa; Navdeep S Chandel; Paul T Schumacker
Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing.
Circulation research 2001;88(12):1259-66.
2001: Zhenhai Yao; Bradley C McPherson; Huiping Liu; Zuohui Shao; Chunying Li; Yimin Qin; Terry Vanden Hoek; Lance B Becker; Paul T Schumacker
Signal transduction of flumazenil-induced preconditioning in myocytes.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1249-55.
2001: Zuohui Shao; Chunying Li; Lance B Becker; Terry Vanden Hoek; Paul T Schumacker; Anoja S Attele; Li Zhang; J Xie; C Yuan
Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes.
Journal of ethnopharmacology 2001;74(1):63-8.
2000: Navdeep S Chandel; David S McClintock; C E Feliciano; T M Wood; J Andres Melendez; Ana M Rodriguez; Paul T Schumacker
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
The Journal of biological chemistry 2000;275(33):25130-8.
2000: Navdeep S Chandel; Matthew G Vander Heiden; Craig Thompson; Paul T Schumacker
Redox regulation of p53 during hypoxia.
Oncogene 2000;19(34):3840-8.
2000: HA Shiels; X Li; Paul T Schumacker; Emin Maltepe; PA Padrid; Anne I Sperling; Craig Thompson; Tullia Lindsten
TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.
The American journal of pathology 2000;157(2):679-88.
2000: Navdeep S Chandel; W C Trzyna; David S McClintock; Paul T Schumacker
Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):1013-21.
2000: N S Chandel; Paul T Schumacker
Cellular oxygen sensing by mitochondria: old questions, new insight.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(5):1880-9.
2000: Matthew G Vander Heiden; Navdeep S Chandel; X X Li; Paul T Schumacker; Marco Colombini; Craig Thompson
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4666-71.
2000: Terry Vanden Hoek; Lance B Becker; Zuo-Hui Shao; Chang-Qing Li; Paul T Schumacker
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Circulation research 2000;86(5):541-8.
1999: Zhenhai Yao; J Tong; X Tan; Chunying Li; Zuohui Shao; W C Kim; Terry Vanden Hoek; Lance B Becker; Clarence Alvin Head; Paul T Schumacker
Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes.
The American journal of physiology 1999;277(6 Pt 2):H2504-9.
1999: Lance B Becker; Terry Vanden Hoek; Zuo-Hui Shao; Chang-Qing Li; Paul T Schumacker
Generation of superoxide in cardiomyocytes during ischemia before reperfusion.
The American journal of physiology 1999;277(6 Pt 2):H2240-6.
1999: Mir H Ali; S A Schlidt; Navdeep S Chandel; Karen L Hynes; Paul T Schumacker; Bruce Gewertz
Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction.
The American journal of physiology 1999;277(5 Pt 1):L1057-65.
1999: Zuo-Hui Shao; Chang-Qing Li; Terry Vanden Hoek; Lance B Becker; Paul T Schumacker; Ji An Wu; Anoja S Attele; Chun-Su Yuan
Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes.
Journal of molecular and cellular cardiology 1999;31(10):1885-95.
1999: Matthew G Vander Heiden; Navdeep S Chandel; Paul T Schumacker; Craig Thompson
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.
Molecular cell 1999;3(2):159-67.
1999: Craig Thompson; Jeffrey C Rathmell; Kenneth A Frauwirth; Tullia Lindsten; Charles Rudin; Joseph T Opferman; Philip G Ashton-Rickardt; Marian H Harris; Navdeep S Chandel; Paul T Schumacker; Matthew G Vander Heiden
What keeps a resting T cell alive?
Cold Spring Harbor symposia on quantitative biology 1999;64():383-7.
1999: James R Brorson; Paul T Schumacker; H Zhang
Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):147-58.
1998: Navdeep S Chandel; Emin Maltepe; E Goldwasser; C E Mathieu; M Celeste Simon; Paul T Schumacker
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11715-20.
1998: Terry Vanden Hoek; Lance B Becker; Zuohui Shao; Chunying Li; Paul T Schumacker
Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes.
The Journal of biological chemistry 1998;273(29):18092-8.
1998: J Duranteau; Navdeep S Chandel; Andre Kulisz; Zuohui Shao; Paul T Schumacker
Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes.
The Journal of biological chemistry 1998;273(19):11619-24.
1998: G R Scott Budinger; J Duranteau; Navdeep S Chandel; Paul T Schumacker
Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor.
The Journal of biological chemistry 1998;273(6):3320-6.
1997: Matthew G Vander Heiden; Navdeep S Chandel; Edward K Williamson; Paul T Schumacker; Craig Thompson
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.
Cell 1997;91(5):627-37.
1997: Terry Vanden Hoek; Chunying Li; Zuohui Shao; Paul T Schumacker; Lance B Becker
Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion.
Journal of molecular and cellular cardiology 1997;29(9):2571-83.
1997: Terry Vanden Hoek; Zuohui Shao; Chunying Li; Paul T Schumacker; Lance B Becker
Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes.
Journal of molecular and cellular cardiology 1997;29(9):2441-50.
1997: Navdeep S Chandel; G R Scott Budinger; S H Choe; Paul T Schumacker
Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes.
The Journal of biological chemistry 1997;272(30):18808-16.
1997: H V Connolly; L A Maginniss; Paul T Schumacker
Transit time heterogeneity in canine small intestine: significance for oxygen transport.
The Journal of clinical investigation 1997;99(2):228-38.
1996: Navdeep S Chandel; G R Scott Budinger; Paul T Schumacker
Molecular oxygen modulates cytochrome c oxidase function.
The Journal of biological chemistry 1996;271(31):18672-7.
1996: Terry Vanden Hoek; Zuohui Shao; Chunying Li; R Zak; Paul T Schumacker; Lance B Becker
Reperfusion injury on cardiac myocytes after simulated ischemia.
The American journal of physiology 1996;270(4 Pt 2):H1334-41.
1996: G R Scott Budinger; Ted Feldman; Paul T Schumacker
O2 supply dependence of respiration in patients with mitral stenosis undergoing valvuloplasty.
American journal of respiratory and critical care medicine 1996;153(3):1034-40.
1996: G R Scott Budinger; Navdeep S Chandel; Zuo-Hui Shao; Chang-Qing Li; A Melmed; Lance B Becker; Paul T Schumacker
Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes.
The American journal of physiology 1996;270(1 Pt 1):L44-53.
1995: Navdeep S Chandel; G R Scott Budinger; R A Kemp; Paul T Schumacker
Inhibition of cytochrome-c oxidase activity during prolonged hypoxia.
The American journal of physiology 1995;268(6 Pt 1):L918-25.
1995: Paul T Schumacker; J Kazaglis; H V Connolly; R W Samsel; Michael F O'Connor; Jason G Umans
Systemic and gut O2 extraction during endotoxemia. Role of nitric oxide synthesis.
American journal of respiratory and critical care medicine 1995;151(1):107-15.
1994: R W Samsel; Paul T Schumacker
Systemic hemorrhage augments local O2 extraction in canine intestine.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;77(5):2291-8.
1994: R W Samsel; Gregory A Schmidt; Jesse B Hall; L D Wood; Sanjeev G Shroff; Paul T Schumacker
Cardiovascular physiology teaching: computer simulations vs. animal demonstrations.
The American journal of physiology 1994;266(6 Pt 3):S36-46.
1994: Paul T Schumacker; J S Soble; Ted Feldman
Oxygen delivery and uptake relationships in patients with aortic stenosis.
American journal of respiratory and critical care medicine 1994;149(5):1123-31.
1994: L A Maginniss; H Connolly; R W Samsel; Paul T Schumacker
Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(4):1454-61.
1994: R W Samsel; T H Lewis; William M. Sanders; L D Wood; Paul T Schumacker
The effect of adrenergic agonists on the systemic response to hemorrhage.
Journal of critical care 1994;9(1):25-33.
1994: Marc B Hershenson; Mark E Wylam; Naresh M Punjabi; Jason G Umans; Paul T Schumacker; Richard W Mitchell; Julian Solway
Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(2):743-9.
1993: Constantine A Manthous; Paul T Schumacker; Anne S Pohlman; Gregory A Schmidt; Jesse B Hall; R W Samsel; L D Wood
Absence of supply dependence of oxygen consumption in patients with septic shock.
Journal of critical care 1993;8(4):203-11.
1993: Jason G Umans; Mark E Wylam; R W Samsel; J Edwards; Paul T Schumacker
Effects of endotoxin in vivo on endothelial and smooth-muscle function in rabbit and rat aorta.
The American review of respiratory disease 1993;148(6 Pt 1):1638-45.
1993: Paul T Schumacker; Navdeep S Chandel; A G Agusti
Oxygen conformance of cellular respiration in hepatocytes.
The American journal of physiology 1993;265(4 Pt 1):L395-402.
1993: Mark E Wylam; R W Samsel; Paul T Schumacker; Jason G Umans
Extracellular calcium and intrinsic tone in the human umbilical artery.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1475-81.
1992: R Drazenovic; R W Samsel; Mark E Wylam; Claire Doerschuk; Paul T Schumacker
Regulation of perfused capillary density in canine intestinal mucosa during endotoxemia.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(1):259-65.
1991: R W Samsel; Paul T Schumacker
Oxygen delivery to tissues.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1991;4(10):1258-67.
1991: R W Samsel; D Cherqui; A Pietrabissa; William M. Sanders; M Roncella; J C Emond; Paul T Schumacker
Hepatic oxygen and lactate extraction during stagnant hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(1):186-93.
1990: Paul T Schumacker; R W Samsel
Oxygen supply and consumption in the adult respiratory distress syndrome.
Clinics in chest medicine 1990;11(4):715-22.
1990: Mark E Wylam; R W Samsel; Jason G Umans; Richard W Mitchell; Alan R Leff; Paul T Schumacker
Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro.
The American review of respiratory disease 1990;142(6 Pt 1):1263-7.
1989: Jacob I Sznajder; A Nahum; G Crawford; E R Pollak; Paul T Schumacker; L D Wood
Alveolar pressure inhomogeneity and gas exchange during constant-flow ventilation in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(4):1489-94.
1989: Paul T Schumacker; R W Samsel
Analysis of oxygen delivery and uptake relationships in the Krogh tissue model.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(3):1234-44.
1989: D W Ray; E P Ingenito; M Strek; Paul T Schumacker; Julian Solway
Longitudinal distribution of canine respiratory heat and water exchanges.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(6):2788-98.
1989: Donald L Bredle; R W Samsel; Paul T Schumacker; SM Cain
Critical O2 delivery to skeletal muscle at high and low PO2 in endotoxemic dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(6):2553-8.
1989: Paul T Schumacker; R W Samsel; Jacob I Sznajder; L D Wood; Julian Solway
Gas density dependence of regional VA/V and VA/Q inequality during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1722-9.
1989: Paul T Schumacker; R W Samsel
Oxygen delivery and uptake by peripheral tissues: physiology and pathophysiology.
Critical care clinics 1989;5(2):255-69.
1988: Paul T Schumacker; Julian Solway; L D Wood; Jacob I Sznajder
Lobar contribution to VA/Q inequality during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(5):2132-7.
1988: R W Samsel; D P Nelson; William M. Sanders; L D Wood; Paul T Schumacker
Effect of endotoxin on systemic and skeletal muscle O2 extraction.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(3):1377-82.
1988: D P Nelson; R W Samsel; L D Wood; Paul T Schumacker
Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(6):2410-9.
1988: R W Samsel; Paul T Schumacker
Determination of the critical O2 delivery from experimental data: sensitivity to error.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(5):2074-82.
1988: A Nahum; Jacob I Sznajder; Julian Solway; L D Wood; Paul T Schumacker
Pressure, flow, and density relationships in airway models during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(5):2066-73.
1987: D P Nelson; C Beyer; R W Samsel; L D Wood; Paul T Schumacker
Pathological supply dependence of O2 uptake during bacteremia in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(4):1487-92.
1987: Paul T Schumacker; J Rowland; S Saltz; D P Nelson; L D Wood
Effects of hyperthermia and hypothermia on oxygen extraction by tissues during hypovolemia.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(3):1246-52.
1987: Paul T Schumacker; Jacob I Sznajder; A Nahum; L D Wood
Ventilation-perfusion inequality during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(3):1255-63.