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John Blanchard

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
22
Vetting, Matthew
16
Zheng, Renjian
13
Hegde, Subray
12
Argyrou, Argyrides
12
Roderick, Steven
11
Scapin, Giovanna
8
Yu, Michael
8
Magnet, Sophie
7
de Carvalho, Luiz Pedro
6
Marcinkeviciene, JA
6
Vederas, John
5
Sacchettini, James
4
Sutherland, Andrew
4
Frantom, Patrick
4
Errey, James

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Publications

TOP 3
Sikora Alison L; Cahill Sean M; Blanchard John S
Enterobactin synthetase-catalyzed formation of P(1),P(3)-diadenosine-5'-tetraphosphate.
Fan Fan; Vetting Matthew W; Frantom Patrick A; Blanchard John S
Structures and mechanisms of the mycothiol biosynthetic enzymes.
Frantom Patrick A; Zhang Hui-Min; Emmett Mark R; Marshall Alan G; Blanchard John S
Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry.

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All Publications

2009: Sikora Alison L; Cahill Sean M; Blanchard John S
Enterobactin synthetase-catalyzed formation of P(1),P(3)-diadenosine-5'-tetraphosphate.
Biochemistry 2009;48(46):10827-9.
2009: Fan Fan; Vetting Matthew W; Frantom Patrick A; Blanchard John S
Structures and mechanisms of the mycothiol biosynthetic enzymes.
Current opinion in chemical biology 2009;13(4):444-52.
2009: Frantom Patrick A; Zhang Hui-Min; Emmett Mark R; Marshall Alan G; Blanchard John S
Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry.
Biochemistry 2009;48(31):7457-64.
2009: Fan Fan; Blanchard John S
Toward the catalytic mechanism of a cysteine ligase (MshC) from Mycobacterium smegmatis: an enzyme involved in the biosynthetic pathway of mycothiol.
Biochemistry 2009;48(30):7150-9.
2009: Vetting Matthew W; Hegde Subray S; Blanchard John S
Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 5):462-9.
2009: de Carvalho Luiz Pedro S; Frantom Patrick A; Argyrou Argyrides; Blanchard John S
Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Biochemistry 2009;48(9):1996-2004.
2009: Hugonnet Jean-Emmanuel; Tremblay Lee W; Boshoff Helena I; Barry Clifton E; Blanchard John S
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.
Science (New York, N.Y.) 2009;323(5918):1215-8.
2009: Stoll Vincent S; Blanchard John S
Buffers: principles and practice.
Methods in enzymology 2009;463():43-56.
2008: Tremblay L W; Fan F; Vetting M W; Blanchard J S
The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.
Biochemistry 2008;47(50):13326-35.
2008: Khrapunov Sergei; Cheng Huiyong; Hegde Subray; Blanchard John; Brenowitz Michael
Solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA.
The Journal of biological chemistry 2008;283(52):36290-9.
2008: Vetting Matthew W; Errey James C; Blanchard John S
Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 11):978-85.
2008: Sikora Alison L; Frankel Brenda A; Blanchard John S
Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis.
Biochemistry 2008;47(40):10781-9.
2008: Vetting Matthew W; Bareich David C; Yu Michael; Blanchard John S
Crystal structure of RimI from Salmonella typhimurium LT2, the GNAT responsible for N(alpha)-acetylation of ribosomal protein S18.
Protein science : a publication of the Protein Society 2008;17(10):1781-90.
2008: Vetting Matthew W; Park Chi Hye; Hegde Subray S; Jacoby George A; Hooper David C; Blanchard John S
Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.
Biochemistry 2008;47(37):9825-35.
2008: Frankel Brenda A; Blanchard John S
Mechanistic analysis of Mycobacterium tuberculosis Rv1347c, a lysine Nepsilon-acyltransferase involved in mycobactin biosynthesis.
Archives of biochemistry and biophysics 2008;477(2):259-66.
2008: Magalhães Maria L B; Argyrou Argyrides; Cahill Sean M; Blanchard John S
Kinetic and mechanistic analysis of the Escherichia coli ribD-encoded bifunctional deaminase-reductase involved in riboflavin biosynthesis.
Biochemistry 2008;47(24):6499-507.
2008: Vetting Matthew W; Frantom Patrick A; Blanchard John S
Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis.
The Journal of biological chemistry 2008;283(23):15834-44.
2008: Tremblay Lee W; Hugonnet Jean-Emmanuel; Blanchard John S
Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.
Biochemistry 2008;47(19):5312-6.
2008: Williams LaKenya; Fan Fan; Blanchard John S; Raushel Frank M
Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC).
Biochemistry 2008;47(16):4843-50.
2008: Magalhães Maria L B; Vetting Matthew W; Gao Feng; Freiburger Lee; Auclair Karine; Blanchard John S
Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.
Biochemistry 2008;47(2):579-84.
2007: Pillai Bindu; Cherney Maia; Diaper Christopher M; Sutherland Andrew; Blanchard John S; Vederas John C; James Michael N G
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.
Biochemical and biophysical research communications 2007;363(3):547-53.
2007: Hugonnet Jean-Emmanuel; Blanchard John S
Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate.
Biochemistry 2007;46(43):11998-2004.
2007: Fan Fan; Luxenburger Andreas; Painter Gavin F; Blanchard John S
Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC).
Biochemistry 2007;46(40):11421-9.
2007: Argyrou Argyrides; Vetting Matthew W; Blanchard John S
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
Journal of the American Chemical Society 2007;129(31):9582-3.
2007: Hegde Subray S; Chandler Jonathan; Vetting Matthew W; Yu Michael; Blanchard John S
Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase.
Biochemistry 2007;46(24):7187-95.
2007: Vetting Matthew W; Hegde Subray S; Hazleton Keith Z; Blanchard John S
Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.
Protein science : a publication of the Protein Society 2007;16(4):755-60.
2006: Yu Michael; Magalhães Maria L B; Cook Paul F; Blanchard John S
Bisubstrate inhibition: Theory and application to N-acetyltransferases.
Biochemistry 2006;45(49):14788-94.
2006: Yu Michael; de Carvalho Luiz Pedro Sorio; Sun Guangxing; Blanchard John S
Activity-based substrate profiling for Gcn5-related N-acetyltransferases: the use of chloroacetyl-coenzyme A to identify protein substrates.
Journal of the American Chemical Society 2006;128(48):15356-7.
2006: Argyrou Argyrides; Jin Lianji; Siconilfi-Baez Linda; Angeletti Ruth H; Blanchard John S
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
Biochemistry 2006;45(47):13947-53.
2006: Wing Corin; Errey James C; Mukhopadhyay Balaram; Blanchard John S; Field Robert A
Expression and initial characterization of WbbI, a putative D-Galf:alpha-D-Glc beta-1,6-galactofuranosyltransferase from Escherichia coli K-12.
Organic & biomolecular chemistry 2006;4(21):3945-50.
2006: Silva Rafael G; de Carvalho Luiz Pedro S; Blanchard John S; Santos Diógenes S; Basso Luiz A
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms.
Biochemistry 2006;45(43):13064-73.
2006: de Carvalho Luiz Pedro S; Blanchard John S
Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Biochemistry 2006;45(29):8988-99.
2006: de Carvalho Luiz Pedro S; Blanchard John S
Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis alpha-isopropylmalate synthase.
Archives of biochemistry and biophysics 2006;451(2):141-8.
2006: Pillai Bindu; Cherney Maia M; Diaper Christopher M; Sutherland Andrew; Blanchard John S; Vederas John C; James Michael N G
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8668-73.
2006: Argyrou Argyrides; Vetting Matthew W; Aladegbami Bola; Blanchard John S
Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.
Nature structural & molecular biology 2006;13(5):408-13.
2006: Errey James C; Blanchard John S
Functional annotation and kinetic characterization of PhnO from Salmonella enterica.
Biochemistry 2006;45(9):3033-9.
2006: Vetting Matthew W; Yu Michael; Rendle Phillip M; Blanchard John S
The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase.
The Journal of biological chemistry 2006;281(5):2795-802.
2006: Vetting Matthew W; Hegde Subray S; Fajardo J Eduardo; Fiser Andras; Roderick Steven L; Takiff Howard E; Blanchard John S
Pentapeptide repeat proteins.
Biochemistry 2006;45(1):1-10.
2005: Magalhaes Maria L B; Blanchard John S
The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli.
Biochemistry 2005;44(49):16275-83.
2005: Diaper Christopher M; Sutherland Andrew; Pillai Bindu; James Michael N G; Semchuk Paul; Blanchard John S; Vederas John C
The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.
Organic & biomolecular chemistry 2005;3(24):4402-11.
2005: Blanchard John S
Old approach yields new antibiotic.
Nature medicine 2005;11(10):1045-6.
2005: de Carvalho Luiz P S; Argyrou Argyrides; Blanchard John S
Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine.
Journal of the American Chemical Society 2005;127(28):10004-5.
2005: Hegde Subray S; Vetting Matthew W; Roderick Steven L; Mitchenall Lesley A; Maxwell Anthony; Takiff Howard E; Blanchard John S
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.
Science (New York, N.Y.) 2005;308(5727):1480-3.
2005: Vetting Matthew W; de Carvalho Luiz Pedro S; Roderick Steven L; Blanchard John S
A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
The Journal of biological chemistry 2005;280(23):22108-14.
2005: Errey James C; Blanchard John S
Functional characterization of a novel ArgA from Mycobacterium tuberculosis.
Journal of bacteriology 2005;187(9):3039-44.
2005: Magnet Sophie; Blanchard John S
Molecular insights into aminoglycoside action and resistance.
Chemical reviews 2005;105(2):477-98.
2005: Vetting Matthew W; S de Carvalho Luiz Pedro; Yu Michael; Hegde Subray S; Magnet Sophie; Roderick Steven L; Blanchard John S
Structure and functions of the GNAT superfamily of acetyltransferases.
Archives of biochemistry and biophysics 2005;433(1):212-26.
2004: Guillemot Didier; Bonacorsi Stephane; Blanchard John S; Weber Philippe; Simon Sylvie; Guesnon Bruno; Bingen Edouard; Carbon Claude
Amoxicillin-clavulanate therapy increases childhood nasal colonization by methicillin-susceptible Staphylococcus aureus strains producing high levels of penicillinase.
Antimicrobial agents and chemotherapy 2004;48(12):4618-23.
2004: Argyrou Argyrides; Vetting Matthew W; Blanchard John S
Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis.
The Journal of biological chemistry 2004;279(50):52694-702.
2004: Zheng Renjian; Dam Tarum K; Brewer C Fred; Blanchard John S
Active site residues in Mycobacterium tuberculosis pantothenate synthetase required in the formation and stabilization of the adenylate intermediate.
Biochemistry 2004;43(22):7171-8.
2004: Vetting Matthew W; Magnet Sophie; Nieves Edward; Roderick Steven L; Blanchard John S
A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones.
Chemistry & biology 2004;11(4):565-73.
2004: Argyrou Argyrides; Blanchard John S
Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase.
Biochemistry 2004;43(14):4375-84.
2004: Disney Matthew D; Magnet Sophie; Blanchard John S; Seeberger Peter H
Aminoglycoside microarrays to study antibiotic resistance.
Angewandte Chemie (International ed. in English) 2004;43(12):1591-4.
2004: Magnet Sophie; Blanchard John S
Mechanistic and kinetic study of the ATP-dependent DNA ligase of Neisseria meningitidis.
Biochemistry 2004;43(3):710-7.
2004: Argyrou Argyrides; Blanchard John S
Flavoprotein disulfide reductases: advances in chemistry and function.
Progress in nucleic acid research and molecular biology 2004;78():89-142.
2003: Zheng Renjian; Blanchard John S
Substrate specificity and kinetic isotope effect analysis of the Eschericia coli ketopantoate reductase.
Biochemistry 2003;42(38):11289-96.
2003: Cirilli Maurizio; Zheng Renjian; Scapin Giovanna; Blanchard John S
The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity.
Biochemistry 2003;42(36):10644-50.
2003: Vetting Matthew W; Roderick Steven L; Yu Michael; Blanchard John S
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
Protein science : a publication of the Protein Society 2003;12(9):1954-9.
2003: Vogt Ryan N; Steenkamp Daniel J; Zheng Renjian; Blanchard John S
The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.
The Biochemical journal 2003;374(Pt 3):657-66.
2003: Vetting M; Roderick S L; Hegde S; Magnet S; Blanchard J S
What can structure tell us about in vivo function? The case of aminoglycoside-resistance genes.
Biochemical Society transactions 2003;31(Pt 3):520-2.
2003: Hegde Subray S; Blanchard John S
Kinetic and mechanistic characterization of recombinant Lactobacillus viridescens FemX (UDP-N-acetylmuramoyl pentapeptide-lysine N6-alanyltransferase).
The Journal of biological chemistry 2003;278(25):22861-7.
2003: Williams LaKenya; Zheng Renjian; Blanchard John S; Raushel Frank M
Positional isotope exchange analysis of the pantothenate synthetase reaction.
Biochemistry 2003;42(17):5108-13.
2003: Magnet Sophie; Smith Terry-Ann; Zheng Renjian; Nordmann Patrice; Blanchard John S
Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.
Antimicrobial agents and chemotherapy 2003;47(5):1577-83.
2003: Blanchard John S
Resisting bacterial drug resistance.
Chemistry & biology 2003;10(2):104-6.
2003: Argyrou Argyrides; Sun Guangxing; Palfey Bruce A; Blanchard John S
Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.
Biochemistry 2003;42(7):2218-28.
2003: Sugantino Michele; Zheng Renjian; Yu Michael; Blanchard John S
Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids.
Biochemistry 2003;42(1):191-9.
2002: Argyrou Argyrides; Blanchard John S; Palfey Bruce A
The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis.
Biochemistry 2002;41(49):14580-90.
2002: Schroeder E K; de Souza N; Santos D S; Blanchard J S; Basso L A
Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis.
Current pharmaceutical biotechnology 2002;3(3):197-225.
2002: Vetting Matthew W; Hegde Subray S; Javid-Majd Farah; Blanchard John S; Roderick Steven L
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.
Nature structural biology 2002;9(9):653-8.
2002: Hegde Subray S; Dam Tarun K; Brewer C Fred; Blanchard John S
Thermodynamics of aminoglycoside and acyl-coenzyme A binding to the Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase.
Biochemistry 2002;41(23):7519-27.
2002: Beaman Todd W; Vogel Kurt W; Drueckhammer Dale G; Blanchard John S; Roderick Steven L
Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase.
Protein science : a publication of the Protein Society 2002;11(4):974-9.
2001: Hegde S S; Javid-Majd F; Blanchard J S
Overexpression and mechanistic analysis of chromosomally encoded aminoglycoside 2'-N-acetyltransferase (AAC(2')-Ic) from Mycobacterium tuberculosis.
The Journal of biological chemistry 2001;276(49):45876-81.
2001: Zheng R; Blanchard J S
Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase.
Biochemistry 2001;40(43):12904-12.
2001: Argyrou A; Blanchard J S
Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes.
Biochemistry 2001;40(38):11353-63.
2001: Shi W; Basso L A; Santos D S; Tyler P C; Furneaux R H; Blanchard J S; Almo S C; Schramm V L
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry 2001;40(28):8204-15.
2001: Basso L A; Santos D S; Shi W; Furneaux R H; Tyler P C; Schramm V L; Blanchard J S
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
Biochemistry 2001;40(28):8196-203.
2001: Patel M P; Blanchard J S
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
Biochemistry 2001;40(17):5119-26.
2001: Magnet S; Lambert T; Courvalin P; Blanchard J S
Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase.
Biochemistry 2001;40(12):3700-9.
2001: Paiva A M; Vanderwall D E; Blanchard J S; Kozarich J W; Williamson J M; Kelly T M
Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis.
Biochimica et biophysica acta 2001;1545(1-2):67-77.
2000: Zheng R; Blanchard J S
Identification of active site residues in E. coli ketopantoate reductase by mutagenesis and chemical rescue.
Biochemistry 2000;39(51):16244-51.
2000: Caplan J F; Zheng R; Blanchard J S; Vederas J C
Vinylogous amide analogues of diaminopimelic acid (DAP) as inhibitors of enzymes involved in bacterial lysine biosynthesis.
Organic letters 2000;2(24):3857-60.
2000: Cirilli M; Scapin G; Sutherland A; Vederas J C; Blanchard J S
The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate.
Protein science : a publication of the Protein Society 2000;9(10):2034-7.
2000: Barlow J N; Blanchard J S
Enzymatic synthesis of UDP-(3-deoxy-3-fluoro)-D-galactose and UDP-(2-deoxy-2-fluoro)-D-galactose and substrate activity with UDP-galactopyranose mutase.
Carbohydrate research 2000;328(4):473-80.
2000: Brunhuber N M; Thoden J B; Blanchard J S; Vanhooke J L
Rhodococcus L-phenylalanine dehydrogenase: kinetics, mechanism, and structural basis for catalytic specificity.
Biochemistry 2000;39(31):9174-87.
2000: Born T L; Franklin M; Blanchard J S
Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Haemophilus influenzae met2-encoded homoserine transacetylase.
Biochemistry 2000;39(29):8556-64.
2000: Zheng R; Blanchard J S
Kinetic and mechanistic analysis of the E. coli panE-encoded ketopantoate reductase.
Biochemistry 2000;39(13):3708-17.
2000: Javid-Majd F; Blanchard J S
Mechanistic analysis of the argE-encoded N-acetylornithine deacetylase.
Biochemistry 2000;39(6):1285-93.
1999: Born T L; Blanchard J S
Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Escherichia coli metA-encoded homoserine transsuccinylase.
Biochemistry 1999;38(43):14416-23.
1999: Born T L; Blanchard J S
Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis.
Current opinion in chemical biology 1999;3(5):607-13.
1999: Patel M P; Blanchard J S
Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase.
Biochemistry 1999;38(36):11827-33.
1999: Koo C W; Blanchard J S
Chemical mechanism of Haemophilus influenzae diaminopimelate epimerase.
Biochemistry 1999;38(14):4416-22.
1999: Ledwidge R; Blanchard J S
The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
Biochemistry 1999;38(10):3019-24.
1999: Vanhooke J L; Thoden J B; Brunhuber N M; Blanchard J S; Holden H M
Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism.
Biochemistry 1999;38(8):2326-39.
1998: Cirilli M; Zheng R; Scapin G; Blanchard J S
Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.
Biochemistry 1998;37(47):16452-8.
1998: Wang P F; Marcinkeviciene J; Williams C H; Blanchard J S
Thioredoxin reductase-thioredoxin fusion enzyme from Mycobacterium leprae: comparison with the separately expressed thioredoxin reductase.
Biochemistry 1998;37(46):16378-89.
1998: Wilson T; de Lisle G W; Marcinkeviciene J A; Blanchard J S; Collins D M
Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties.
Microbiology (Reading, England) 1998;144 ( Pt 10)():2687-95.
1998: Patel M P; Marcinkeviciene J; Blanchard J S
Enterococcus faecalis glutathione reductase: purification, characterization and expression under normal and hyperbaric O2 conditions.
FEMS microbiology letters 1998;166(1):155-63.
1998: Basso L A; Zheng R; Musser J M; Jacobs W R; Blanchard J S
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
The Journal of infectious diseases 1998;178(3):769-75.
1998: Born T L; Zheng R; Blanchard J S
Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism.
Biochemistry 1998;37(29):10478-87.
1998: Beaman T W; Blanchard J S; Roderick S L
The conformational change and active site structure of tetrahydrodipicolinate N-succinyltransferase.
Biochemistry 1998;37(29):10363-9.
1998: Scapin G; Cirilli M; Reddy S G; Gao Y; Vederas J C; Blanchard J S
Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase.
Biochemistry 1998;37(10):3278-85.
1998: Wang F; Scapin G; Blanchard J S; Angeletti R H
Substrate binding and conformational changes of Clostridium glutamicum diaminopimelate dehydrogenase revealed by hydrogen/deuterium exchange and electrospray mass spectrometry.
Protein science : a publication of the Protein Society 1998;7(2):293-9.
1998: Blanchard J S
The ying and yang of rifampicin.
Nature medicine 1998;4(1):14-5.
1998: Basso L A; Blanchard J S
Resistance to antitubercular drugs.
Advances in experimental medicine and biology 1998;456():115-44.
1998: Scapin G; Blanchard J S
Enzymology of bacterial lysine biosynthesis.
Advances in enzymology and related areas of molecular biology 1998;72():279-324.
1997: Scapin G; Reddy S G; Zheng R; Blanchard J S
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
Biochemistry 1997;36(49):15081-8.
1997: Marcinkeviciene J; Blanchard J S
Catalytic properties of lipoamide dehydrogenase from Mycobacterium smegmatis.
Archives of biochemistry and biophysics 1997;340(2):168-76.
1997: Wang F; Blanchard J S; Tang X J
Hydrogen exchange/electrospray ionization mass spectrometry studies of substrate and inhibitor binding and conformational changes of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1997;36(13):3755-9.
1997: Beaman T W; Binder D A; Blanchard J S; Roderick S L
Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase.
Biochemistry 1997;36(3):489-94.
1996: Scapin G; Reddy S G; Blanchard J S
Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum.
Biochemistry 1996;35(42):13540-51.
1996: Reddy S G; Scapin G; Blanchard J S
Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes.
Biochemistry 1996;35(41):13294-302.
1996: Binder D A; Blanchard J S; Roderick S L
Crystallization and preliminary crystallographic analysis of tetrahydrodipicolinate-N-succinyltransferase.
Proteins 1996;26(1):115-7.
1996: Reddy S G; Scapin G; Blanchard J S
Expression, purification, and crystallization of meso-diaminopimelate dehydrogenase from Corynebacterium glutamicum.
Proteins 1996;25(4):514-6.
1996: Sacchettini J C; Blanchard J S
The structure and function of the isoniazid target in M. tuberculosis.
Research in microbiology 1996;147(1-2):36-43.
1996: Kliukiené R; Maroziené A; Cénas N; Becker K; Blanchard J S
Photoinactivation of trypanothione reductase and glutathione reductase by Al-phthalocyanine tetrasulfonate and hematoporphyrin.
Biochemical and biophysical research communications 1996;218(2):629-32.
1996: Tao W; Grubmeyer C; Blanchard J S
Transition state structure of Salmonella typhimurium orotate phosphoribosyltransferase.
Biochemistry 1996;35(1):14-21.
1996: Blanchard J S
Molecular mechanisms of drug resistance in Mycobacterium tuberculosis.
Annual review of biochemistry 1996;65():215-39.
1995: Zheng R; Cenas N; Blanchard J S
Catalytic and potentiometric characterization of E201D and E201Q mutants of Trypanosoma congolense trypanothione reductase.
Biochemistry 1995;34(39):12697-703.
1995: Marcinkeviciene J A; Magliozzo R S; Blanchard J S
Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation.
The Journal of biological chemistry 1995;270(38):22290-5.
1995: Quémard A; Sacchettini J C; Dessen A; Vilcheze C; Bittman R; Jacobs W R; Blanchard J S
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
Biochemistry 1995;34(26):8235-41.
1995: Marcinkeviciene J A; Blanchard J S
Quinone reductase reaction catalyzed by Streptococcus faecalis NADH peroxidase.
Biochemistry 1995;34(20):6621-7.
1995: Scapin G; Blanchard J S; Sacchettini J C
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1995;34(11):3502-12.
1995: Reddy S G; Sacchettini J C; Blanchard J S
Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1995;34(11):3492-501.
1995: Dessen A; Quémard A; Blanchard J S; Jacobs W R; Sacchettini J C
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science (New York, N.Y.) 1995;267(5204):1638-41.
1994: Leichus B N; Blanchard J S
Isotopic analysis of the reaction catalyzed by glycerol dehydrogenase.
Biochemistry 1994;33(48):14642-9.
1994: Tanaka Y; Tao W; Blanchard J S; Hehre E J
Transition state structures for the hydrolysis of alpha-D-glucopyranosyl fluoride by retaining and inverting reactions of glycosylases.
The Journal of biological chemistry 1994;269(51):32306-12.
1994: Cenas N; Bironaite D; Dickancaite E; Anusevicius Z; Sarlauskas J; Blanchard J S
Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase.
Biochemical and biophysical research communications 1994;204(1):224-9.
1994: Brunhuber N M; Banerjee A; Jacobs W R; Blanchard J S
Cloning, sequencing, and expression of Rhodococcus L-phenylalanine dehydrogenase. Sequence comparisons to amino-acid dehydrogenases.
The Journal of biological chemistry 1994;269(23):16203-11.
1994: Cenas N K; Arscott D; Williams C H; Blanchard J S
Mechanism of reduction of quinones by Trypanosoma congolense trypanothione reductase.
Biochemistry 1994;33(9):2509-15.
1994: Brunhuber N M; Blanchard J S
The biochemistry and enzymology of amino acid dehydrogenases.
Critical reviews in biochemistry and molecular biology 1994;29(6):415-67.
1992: Leichus B N; Bradley M; Nadeau K; Walsh C T; Blanchard J S
Kinetic isotope effect analysis of the reaction catalyzed by Trypanosoma congolense trypanothione reductase.
Biochemistry 1992;31(28):6414-20.
1992: Leichus B N; Blanchard J S
Pig heart lipoamide dehydrogenase: solvent equilibrium and kinetic isotope effects.
Biochemistry 1992;31(12):3065-72.
1991: Sweet W L; Blanchard J S
Human erythrocyte glutathione reductase: chemical mechanism and structure of the transition state for hydride transfer.
Biochemistry 1991;30(35):8702-9.
1991: Stoll V S; Blanchard J S
Chemical mechanism and rate-limiting steps in the reaction catalyzed by Streptococcus faecalis NADH peroxidase.
Biochemistry 1991;30(4):942-8.
1990: Vanoni M A; Wong K K; Ballou D P; Blanchard J S
Glutathione reductase: comparison of steady-state and rapid reaction primary kinetic isotope effects exhibited by the yeast, spinach, and Escherichia coli enzymes.
Biochemistry 1990;29(24):5790-6.
1990: Sweet W L; Blanchard J S
Fumarase: viscosity dependence of the kinetic parameters.
Archives of biochemistry and biophysics 1990;277(1):196-202.
1990: Stoll V S; Blanchard J S
Buffers: principles and practice.
Methods in enzymology 1990;182():24-38.
1989: Schiering N; Stoll V S; Blanchard J S; Pai E F
Crystallization and preliminary x-ray diffraction study of the flavoprotein NADH peroxidase from Streptococcus faecalis 10C1.
The Journal of biological chemistry 1989;264(35):21144-5.
1989: Matsui H; Blanchard J S; Brewer C F; Hehre E J
Alpha-secondary tritium kinetic isotope effects for the hydrolysis of alpha-D-glucopyranosyl fluoride by exo-alpha-glucanases.
The Journal of biological chemistry 1989;264(15):8714-6.
1989: Wong K K; Blanchard J S
Human erythrocyte glutathione reductase: pH dependence of kinetic parameters.
Biochemistry 1989;28(8):3586-90.
1988: Wong K K; Vanoni M A; Blanchard J S
Glutathione reductase: solvent equilibrium and kinetic isotope effects.
Biochemistry 1988;27(18):7091-6.
1988: Stoll V S; Blanchard J S
Kinetic mechanism and nucleotide specificity of NADH peroxidase.
Archives of biochemistry and biophysics 1988;260(2):752-62.
1987: Cubells J F; Blanchard J S; Makman M H
The effects of in vivo inactivation of GABA-transaminase and glutamic acid decarboxylase on levels of GABA in the rat retina.
Brain research 1987;419(1-2):208-15.
1986: Cubells J F; Blanchard J S; Smith D M; Makman M H
In vivo action of enzyme-activated irreversible inhibitors of glutamic acid decarboxylase and gamma-aminobutyric acid transaminase in retina vs. brain.
The Journal of pharmacology and experimental therapeutics 1986;238(2):508-14.
1986: Butera L; Englard S; Blanchard J S; Avigad G
Structures of D-threo-2,5-hexodiulose 1-phosphate and D-threo-2,5-hexodiulose 1,6-bisphosphate (5-keto-D-fructose mono- and bis-phosphate) in solution by 13C-N.M.R. spectroscopy.
Carbohydrate research 1986;148(2):179-88.
1985: Burger R M; Blanchard J S; Horwitz S B; Peisach J
The redox state of activated bleomycin.
The Journal of biological chemistry 1985;260(29):15406-9.
1985: Englard S; Blanchard J S; Midelfort C F
Gamma-butyrobetaine hydroxylase: stereochemical course of the hydroxylation reaction.
Biochemistry 1985;24(5):1110-6.
1984: Orr G A; Blanchard J S
High-performance ion-exchange separation of oxidized and reduced nicotinamide adenine dinucleotides.
Analytical biochemistry 1984;142(1):232-4.
1984: Blanchard J S
Buffers for enzymes.
Methods in enzymology 1984;104():404-14.
1983: Blanchard J S; Englard S
gamma-butyrobetaine hydroxylase: primary and secondary tritium kinetic isotope effects.
Biochemistry 1983;22(25):5922-9.
1982: Blanchard J S; Englard S; Kondo A
gamma-Butyrobetaine hydroxylase: a unique protective effect of catalase.
Archives of biochemistry and biophysics 1982;219(2):327-34.
1982: Blanchard J S; Brewer C F; Englard S; Avigad G
Solution structure of 5-keto-D-fructose: relevance to the specificity of hexose kinases.
Biochemistry 1982;21(1):75-81.
1981: Kondo A; Blanchard J S; Englard S
Purification and properties of calf liver gamma-butyrobetaine hydroxylase.
Archives of biochemistry and biophysics 1981;212(2):338-46.
1980: Cook P F; Blanchard J S; Cleland W W
Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions.
Biochemistry 1980;19(21):4853-8.
1980: Blanchard J S; Cleland W W
Use of isotope effects to deduce the chemical mechanism of fumarase.
Biochemistry 1980;19(19):4506-13.
1980: Blanchard J S; Cleland W W
Kinetic and chemical mechanisms of yeast formate dehydrogenase.
Biochemistry 1980;19(15):3543-50.

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