FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ralf Schumann

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Mouse

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Physiology

Co-author Network

Publications

TOP 3
Chin-An Yang; Sandra Bauer; Jan Bornschein; Stephan Hellmig; Christoph Kleinle; Peter Malfertheiner; Carmen Scheibenbogen; Ralf R Schumann; Thomas Wex; Lutz Hamann
A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease.
Martin Eisenblätter; Hermine Gayum; Ariane Buchal; Edith Jasny; Pablo Renner Viveros; Thomas Schneider; Ralf R Schumann; Timo Ulrichs; Janine Zweigner; Ralf Ignatius
Nocardia farcinica activates human dendritic cells and induces secretion of interleukin-23 (IL-23) rather than IL-12p70.
Chin-An Yang; Gerald Grütz; Manuel Guerreiro; Doreen Haase; Lutz Hamann; Martin J Raftery; Günther Schönrich; Ralf R Schumann; Nadine Unterwalder; Hans-Dieter Volk; Carmen Scheibenbogen
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ralf Schumann (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Chin-An Yang; Sandra Bauer; Jan Bornschein; Stephan Hellmig; Christoph Kleinle; Peter Malfertheiner; Carmen Scheibenbogen; Ralf R Schumann; Thomas Wex; Lutz Hamann
A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease.
Helicobacter 2013;18(1):13-21.
2012: Martin Eisenblätter; Hermine Gayum; Ariane Buchal; Edith Jasny; Pablo Renner Viveros; Thomas Schneider; Ralf R Schumann; Timo Ulrichs; Janine Zweigner; Ralf Ignatius
Nocardia farcinica activates human dendritic cells and induces secretion of interleukin-23 (IL-23) rather than IL-12p70.
Infection and immunity 2012;80(12):4195-202.
2012: Chin-An Yang; Gerald Grütz; Manuel Guerreiro; Doreen Haase; Lutz Hamann; Martin J Raftery; Günther Schönrich; Ralf R Schumann; Nadine Unterwalder; Hans-Dieter Volk; Carmen Scheibenbogen
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.
Human immunology 2012;73(8):844-51.
2011: Gunthard Stübs; Ulrich Zähringer; Volker Fingerle; Jörg Rademann; Ralf R Schumann; Nicolas W J Schröder
Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato.
FEMS immunology and medical microbiology 2011;63(1):140-3.
2011: Ralf R Schumann
Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule.
Biochemical Society transactions 2011;39(4):989-93.
2010: Lutz Hamann; George Bedu-Addo; Teunis A Eggelte; Ralf R Schumann; Frank P Mockenhaupt
The toll-like receptor 1 variant S248N influences placental malaria.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2010;10(6):785-9.
2010: Matthew B B McCall; Bart Ferwerda; Joost Hopman; Ivo Ploemen; Boubacar Maiga; Modibo Daou; Amagana Dolo; Cornelus C Hermsen; Ogobara K Doumbo; George Bedu-Addo; Jos W van der Meer; Marita Troye-Blomberg; Andre J A M van der Ven; Ralf R Schumann; Robert W Sauerwein; Frank P Mockenhaupt; Mihai G Netea
Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations.
European cytokine network 2010;21(2):77-83.
2010: Gunthard Stübs; Bernd Rupp; Ralf R Schumann; Nicolas W J Schröder; Jörg Rademann
Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(11):3536-44.
2010: Oliver Kumpf; Evangelos J Giamarellos-Bourboulis; Alexander Koch; Lutz Hamann; Maria Mouktaroudi; Djin-Ye Oh; Eicke Latz; Eva Lorenz; David A Schwartz; Bart Ferwerda; Christina Routsi; Chryssanthi Skalioti; Bart Jan Kullberg; Jos W M van der Meer; Peter M Schlag; Mihai G Netea; Kai Zacharowski; Ralf R Schumann
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
Critical care (London, England) 2010;14(3):R103.
2009: Gunthard Stübs; Volker Fingerle; Bettina Wilske; Ulf B Göbel; Ulrich Zähringer; Ralf R Schumann; Nicolas W J Schröder
Acylated cholesteryl galactosides are specific antigens of borrelia causing lyme disease and frequently induce antibodies in late stages of disease.
The Journal of biological chemistry 2009;284(20):13326-34.
2009: Djin-Ye Oh; Konstantin Baumann; Osamah Hamouda; Jana K Eckert; Konrad Neumann; Claudia Kücherer; Barbara Bartmeyer; Gabriele Poggensee; Nari Oh; Axel Pruss; Heiko Jessen; Ralf R Schumann
A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression.
AIDS (London, England) 2009;23(3):297-307.
2008: Oliver Kumpf; Ralf R Schumann
Genetic influence on bloodstream infections and sepsis.
International journal of antimicrobial agents 2008;32 Suppl 1():S44-50.
2008: Djin-Ye Oh; S Taube; Osamah Hamouda; Claudia Kücherer; Gabriele Poggensee; H Jessen; J K Eckert; Konrad Neumann; A Storek; M Pouliot; P Borgeat; N Oh; Eckart Schreier; Axel Pruss; K Hattermann; Ralf R Schumann
A functional toll-like receptor 8 variant is associated with HIV disease restriction.
The Journal of infectious diseases 2008;198(5):701-9.
2008: Djin-Ye Oh; Heiko Jessen; Claudia Kücherer; Konrad Neumann; Nari Oh; Gabriele Poggensee; Barbara Bartmeyer; Arne Jessen; Axel Pruss; Ralf R Schumann; Osamah Hamouda
CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual.
PloS one 2008;3(7):e2747.
2008: Nicolas W J Schröder; Jana Eckert; Gunthard Stübs; Ralf R Schumann
Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids.
Immunobiology 2008;213(3-4):329-40.
2007: Bart Ferwerda; Matthew B B McCall; Santos Alonso; Evangelos J Giamarellos-Bourboulis; Maria Mouktaroudi; Neskuts Izagirre; Din Syafruddin; Gibson S Kibiki; Tudor Cristea; Anneke Hijmans; Lutz Hamann; Shoshana Israel; Gehad Elghazali; Marita Troye-Blomberg; Oliver Kumpf; Boubacar Maiga; Amagana Dolo; Ogobara K Doumbo; Cornelus C Hermsen; Anton F H Stalenhoef; Reinout van Crevel; Han G Brunner; Djin-Ye Oh; Ralf R Schumann; Concepcion de la Rúa; Robert W Sauerwein; Bart Jan Kullberg; Andre J A M van der Ven; Jos W M van der Meer; Mihai G Netea
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16645-50.
2007: Ralf R Schumann; Tapping Richard
Genomic variants of TLR1--it takes (TLR-)two to tango.
European journal of immunology 2007;37(8):2059-62.
2007: Markus M Heimesaat; André Fischer; Hannah-Katharina Jahn; Julia Niebergall; M Freudenberg; Michael Blaut; Oliver Liesenfeld; Ralf R Schumann; Ulf B Göbel; Stefan Bereswill
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli.
Gut 2007;56(7):941-8.
2007: Christopher M Johnson; Elizabeth A Lyle; Katherine O Omueti; Vitaly A Stepensky; Olcay Yegin; Erkan Alpsoy; Lutz Hamann; Ralf R Schumann; Tapping Richard
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7520-4.
2007: Ralf R Schumann
Malarial fever: hemozoin is involved but Toll-free.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1743-4.
2007: Markus M Heimesaat; André Fischer; Britta Siegmund; Andreas Kupz; Julia Niebergall; David Fuchs; Hannah-Katharina Jahn; Marina Freudenberg; Christoph Loddenkemper; Arvind Batra; Hans-Anton Lehr; Oliver Liesenfeld; Michael Blaut; Ulf B Göbel; Ralf R Schumann; Stefan Bereswill
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4.
PloS one 2007;2(7):e662.
2006: Markus M Heimesaat; Stefan Bereswill; André Fischer; David Fuchs; Daniela Struck; Julia Niebergall; Hannah-Katharina Jahn; Ildiko R Dunay; Annette Moter; Dorothee Maria Gescher; Ralf R Schumann; Ulf B Göbel; Oliver Liesenfeld
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8785-95.
2006: Frank P Mockenhaupt; Lutz Hamann; Christiane von Gaertner; George Bedu-Addo; Cordula von Kleinsorgen; Ralf R Schumann; Ulrich Bienzle
Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.
The Journal of infectious diseases 2006;194(2):184-8.
2006: A Grabig; D Paclik; C Guzy; Anja Dankof; Daniel Baumgart; J Erckenbrecht; B Raupach; Ulrich Sonnenborn; Jana Eckert; Ralf R Schumann; Bertram Wiedenmann; Axel U Dignass; Andreas Sturm
Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways.
Infection and immunity 2006;74(7):4075-82.
2006: Frank P Mockenhaupt; Jakob P Cramer; Lutz Hamann; M S Stegemann; Jana Eckert; Na-Ri Oh; Rowland N Otchwemah; Ekkehart Dietz; Stephan Ehrhardt; Nicolas W J Schröder; Ulrich Bienzle; Ralf R Schumann
Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.
The Journal of communicable diseases 2006;38(3):230-45.
2006: Janine Zweigner; Ralf R Schumann; Joerg R Weber
The role of lipopolysaccharide-binding protein in modulating the innate immune response.
Microbes and infection / Institut Pasteur 2006;8(3):946-52.
2006: Oliver Kumpf; Lutz Hamann; Peter M Schlag; Ralf R Schumann
Pre- and postoperative cytokine release after in vitro whole blood lipopolysaccharide stimulation and frequent toll-like receptor 4 polymorphisms.
Shock (Augusta, Ga.) 2006;25(2):123-8.
2006: Lutz Hamann; Christiane Glaeser; Axel Hamprecht; Michael Gross; Abuzeid Gomma; Ralf R Schumann
Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis.
Clinica chimica acta; international journal of clinical chemistry 2006;364(1-2):303-7.
2006: Frank P Mockenhaupt; Jakob P Cramer; Lutz Hamann; Miriam S Stegemann; Jana Eckert; Na-Ri Oh; Rowland N Otchwemah; Ekkehart Dietz; Stephan Ehrhardt; Nicolas W J Schröder; Ulrich Bienzle; Ralf R Schumann
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):177-82.
2005: Nicolas W J Schröder; Isabel Diterich; Antje Zinke; Jana Eckert; Christian Draing; Volker von Baehr; Dieter Hassler; Susanne Priem; Katrin Hahn; Kathrin S Michelsen; Thomas Hartung; Gerd R Burmester; Ulf B Göbel; Corinna Hermann; Ralf R Schumann
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2534-40.
2005: Nicolas W J Schröder; D Meister; V Wolff; Claudia Christan; Dogan Kaner; Vesna Haban; Peter Purucker; Corinna Hermann; Annette Moter; Ulf B Göbel; Ralf R Schumann
Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene.
Genes and immunity 2005;6(5):448-51.
2005: Lutz Hamann; Abuzeid Gomma; Nicolas W J Schröder; Cordula Stamme; Christiane Glaeser; Susanne Schulz; Michael Gross; Stefan D Anker; Kim Fox; Ralf R Schumann
A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis.
Journal of molecular medicine (Berlin, Germany) 2005;83(6):478-85.
2005: Nicolas W J Schröder; Ralf R Schumann
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease.
The Lancet infectious diseases 2005;5(3):156-64.
2005: Andreas Sturm; Klaus Rilling; Daniel Baumgart; Konstantinos Gargas; Tay Abou-Ghazalé; Bärbel Raupach; Jana Eckert; Ralf R Schumann; Corinne Enders; Ulrich Sonnenborn; Bertram Wiedenmann; Axel U Dignass
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling.
Infection and immunity 2005;73(3):1452-65.
2005: Nicolas W J Schröder; Ralf R Schumann
Non-LPS targets and actions of LPS binding protein (LBP).
Journal of endotoxin research 2005;11(4):237-42.
2005: Oliver Goldenberg; Olfert Landt; Ralf R Schumann; Ulf B Göbel; Lutz Hamann
Use of locked nucleic acid oligonucleotides as hybridization/FRET probes for quantification of 16S rDNA by real-time PCR.
BioTechniques 2005;38(1):29-30, 32.
2005: Lutz Hamann; Christian Alexander; Cordula Stamme; Ulrich Zähringer; Ralf R Schumann
Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms.
Infection and immunity 2005;73(1):193-200.
2004: Ralf R Schumann
Host cell-pathogen interface: molecular mechanisms and genetics.
Vaccine 2004;22 Suppl 1():S21-4.
2004: Bastian Opitz; Andreas W Püschel; Bernd Schmeck; Andreas C Hocke; Simone Rosseau; Sven Hammerschmidt; Ralf R Schumann; Norbert Suttorp; Stefan Hippenstiel
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae.
The Journal of biological chemistry 2004;279(35):36426-32.
2004: Nicolas W J Schröder; Holger Heine; Christian Alexander; Maria Manukyan; Jana Eckert; Lutz Hamann; Ulf B Göbel; Ralf R Schumann
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2683-91.
2004: Oliver Kann; Anja Hoffmann; Ralf R Schumann; Joerg R Weber; Helmut Kettenmann; Uwe-Karsten Hanisch
The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level.
Journal of neurochemistry 2004;90(3):513-25.
2004: Lutz Hamann; Oliver Kumpf; M Müller; A Visintin; Jana Eckert; Peter M Schlag; Ralf R Schumann
A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling.
Genes and immunity 2004;5(4):283-8.
2004: Werner Hallatschek; Gesa Fiedler; Carsten J Kirschning; Fränzi Creutzburg; Norbert Lamping; Andreas Nüssler; Ralf R Schumann
Inhibition of hepatic transcriptional induction of lipopolysaccharide-binding protein by transforming-growth-factor beta 1.
European journal of immunology 2004;34(5):1441-50.
2004: Sonja Von Aulock; Nicolas W J Schröder; Stephanie Traub; Katja Gueinzius; Eva Lorenz; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses.
Infection and immunity 2004;72(3):1828-31.
2004: Lutz Hamann; Axel Hamprecht; Abuzeid Gomma; Ralf R Schumann
Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes.
Journal of immunological methods 2004;285(2):281-91.
2003: Sonja Von Aulock; Nicolas W J Schröder; Katja Gueinzius; Stephanie Traub; Sebastian Hoffmann; Kathrin Graf; Stefanie Dimmeler; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood.
The Journal of infectious diseases 2003;188(6):938-43.
2003: Nicolas W J Schröder; Ursula Schombel; Holger Heine; Ulf B Göbel; Ulrich Zähringer; Ralf R Schumann
Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto.
The Journal of biological chemistry 2003;278(36):33645-53.
2003: Joerg R Weber; Dorette Freyer; Christian Alexander; Nicolas W J Schröder; Anja Reiss; Carsten Küster; Dagmar Pfeil; Elaine I Tuomanen; Ralf R Schumann
Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein.
Immunity 2003;19(2):269-79.
2003: Nicolas W J Schröder; Corinna Hermann; Lutz Hamann; Ulf B Göbel; Thomas Hartung; Ralf R Schumann
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR.
Journal of molecular medicine (Berlin, Germany) 2003;81(6):368-72.
2003: Nicolas W J Schröder; Siegfried Morath; Christian Alexander; Lutz Hamann; Thomas Hartung; Ulrich Zähringer; Ulf B Göbel; Joerg R Weber; Ralf R Schumann
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
The Journal of biological chemistry 2003;278(18):15587-94.
2003: Philipp Henneke; Inga Osmers; Karl Bauer; Norbert Lamping; Hans T Versmold; Ralf R Schumann
Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants.
Journal of perinatal medicine 2003;31(2):176-83.
2002: Karl Georg Häusler; Marco Prinz; Christiane Nolte; Joerg R Weber; Ralf R Schumann; Helmut Kettenmann; Uwe-Karsten Hanisch
Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages.
The European journal of neuroscience 2002;16(11):2113-22.
2002: Olaf Hoffmann; Nikolas Keilwerth; Margarethe Bastholm Bille; Uwe Reuter; Klemens Angstwurm; Ralf R Schumann; Ulrich Dirnagl; Joerg R Weber
Triptans reduce the inflammatory response in bacterial meningitis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(8):988-96.
2002: Lutz Hamann; Cordula Stamme; Artur J Ulmer; Ralf R Schumann
Inhibition of LPS-induced activation of alveolar macrophages by high concentrations of LPS-binding protein.
Biochemical and biophysical research communications 2002;295(2):553-60.
2002: Corinna Hermann; Ingo Spreitzer; Nicolas W J Schröder; Siegfried Morath; Martin D Lehner; Werner Fischer; Christine Schütt; Ralf R Schumann; Thomas Hartung
Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release.
European journal of immunology 2002;32(2):541-51.
2001: Janine Zweigner; H J Gramm; O C Singer; K Wegscheider; Ralf R Schumann
High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes.
Blood 2001;98(13):3800-8.
2001: Kathrin S Michelsen; Alexandra Aicher; Mariette Mohaupt; Thomas Hartung; Stefanie Dimmeler; Carsten J Kirschning; Ralf R Schumann
The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.
The Journal of biological chemistry 2001;276(28):25680-6.
2001: B Opitz; Nicolas W J Schröder; Ingo Spreitzer; Kathrin S Michelsen; Carsten J Kirschning; Werner Hallatschek; Ulrich Zähringer; Thomas Hartung; Ulf B Göbel; Ralf R Schumann
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation.
The Journal of biological chemistry 2001;276(25):22041-7.
2001: Martin D Lehner; Siegfried Morath; K S Michelsen; Ralf R Schumann; Thomas Hartung
Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5161-7.
2001: Nicolas W J Schröder; Dagmar Pfeil; B Opitz; Kathrin S Michelsen; J Amberger; Ulrich Zähringer; Ulf B Göbel; Ralf R Schumann
Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid.
The Journal of biological chemistry 2001;276(13):9713-9.
2000: Nicolas W J Schröder; B Opitz; Norbert Lamping; Kathrin S Michelsen; Ulrich Zähringer; Ulf B Göbel; Ralf R Schumann
Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2683-93.
2000: Norbert Lamping; Ralf R Schumann; R Burger
Detection of two variants of complement component C3 in C3-deficient guinea pigs distinguished by the absence and presence of a thiolester.
Molecular immunology 2000;37(7):333-41.
2000: Klemens Angstwurm; S Reuss; Dorette Freyer; G Arnold; Ulrich Dirnagl; Ralf R Schumann; Joerg R Weber
Induced hypothermia in experimental pneumococcal meningitis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(5):834-8.
2000: Pauline Erwin; H Lewis; S Dolan; P S Tobias; Ralf R Schumann; Norbert Lamping; G Brian Wisdom; Brian J Rowlands; M Isla Halliday
Lipopolysaccharide binding protein in acute pancreatitis.
Critical care medicine 2000;28(1):104-9.
2000: Ralf R Schumann; Eicke Latz
Lipopolysaccharide-binding protein.
Chemical immunology 2000;74():42-60.
2000: Lutz Hamann; Ralf R Schumann; Hans-Dieter Flad; Lore Brade; Ernst Th Rietschel; Artur J Ulmer
Binding of lipopolysaccharide (LPS) to CHO cells does not correlate with LPS-induced NF-kappaB activation.
European journal of immunology 2000;30(1):211-6.
1999: Dorette Freyer; R Manz; A Ziegenhorn; Markus Weih; Klemens Angstwurm; W D Döcke; Andreas Meisel; Ralf R Schumann; Gilbert Schönfelder; Ulrich Dirnagl; Joerg R Weber
Cerebral endothelial cells release TNF-alpha after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4308-14.
1999: Marco Prinz; Oliver Kann; Henning Draheim; Ralf R Schumann; Helmut Kettenmann; Joerg R Weber; Uwe-Karsten Hanisch
Microglial activation by components of gram-positive and -negative bacteria: distinct and common routes to the induction of ion channels and cytokines.
Journal of neuropathology and experimental neurology 1999;58(10):1078-89.
1999: Ralf R Schumann; Janine Zweigner
A novel acute-phase marker: lipopolysaccharide binding protein (LBP).
Clinical chemistry and laboratory medicine : CCLM / FESCC 1999;37(3):271-4.
1998: Klemens Angstwurm; Dorette Freyer; Ulrich Dirnagl; Uwe-Karsten Hanisch; Ralf R Schumann; Karl M Einhäupl; Joerg R Weber
Tumour necrosis factor alpha induces only minor inflammatory changes in the central nervous system, but augments experimental meningitis.
Neuroscience 1998;86(2):627-34.
1998: Norbert Lamping; R Dettmer; Nicolas W J Schröder; Dagmar Pfeil; Werner Hallatschek; R Burger; Ralf R Schumann
LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.
The Journal of clinical investigation 1998;101(10):2065-71.
1998: Ralf R Schumann; Dagmar Pfeil; Dorette Freyer; W Buerger; Norbert Lamping; Carsten J Kirschning; U B Goebel; Joerg R Weber
Lipopolysaccharide and pneumococcal cell wall components activate the mitogen activated protein kinases (MAPK) erk-1, erk-2, and p38 in astrocytes.
Glia 1998;22(3):295-305.
1998: Ralf R Schumann; Claus Belka; D Reuter; Norbert Lamping; Carsten J Kirschning; Joerg R Weber; Dagmar Pfeil
Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells.
Blood 1998;91(2):577-84.
1997: Carsten J Kirschning; J Au-Young; Norbert Lamping; D Reuter; Dagmar Pfeil; J J Seilhamer; Ralf R Schumann
Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins.
Genomics 1997;46(3):416-25.
1997: M M Wurfel; Brian G Monks; Robin R Ingalls; R L Dedrick; RL Delude; D Zhou; Norbert Lamping; Ralf R Schumann; Rolf Thieringer; Matthew J Fenton; Samuel D Wright; Douglas T Golenbock
Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
The Journal of experimental medicine 1997;186(12):2051-6.
1997: Ralf R Schumann; Norbert Lamping; A Hoess
Interchangeable endotoxin-binding domains in proteins with opposite lipopolysaccharide-dependent activities.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5599-605.
1997: Carsten J Kirschning; A Unbehaun; G Fiedler; Werner Hallatschek; Norbert Lamping; Dagmar Pfeil; Ralf R Schumann
The transcriptional activation pattern of lipopolysaccharide binding protein (LBP) involving transcription factors AP-1 and C/EBP beta.
Immunobiology 1997;198(1-3):124-35.
1997: Carsten J Kirschning; A Unbehaun; Norbert Lamping; Dagmar Pfeil; F Herrmann; Ralf R Schumann
Control of transcriptional activation of the lipopolysaccharide binding protein (LBP) gene by proinflammatory cytokines.
Cytokines, cellular & molecular therapy 1997;3(1):59-62.
1996: Norbert Lamping; A Hoess; B Yu; T C Park; Carsten J Kirschning; Dagmar Pfeil; D Reuter; Samuel D Wright; F Herrmann; Ralf R Schumann
Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4648-56.
1996: Ralf R Schumann; Carsten J Kirschning; A Unbehaun; H P Aberle; H P Knope; Norbert Lamping; R J Ulevitch; F Herrmann
The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins.
Molecular and cellular biology 1996;16(7):3490-503.
1996: Regine Landmann; H P Knopf; S Link; Sebastiano Sansano; Ralf R Schumann; Werner Zimmerli
Human monocyte CD14 is upregulated by lipopolysaccharide.
Infection and immunity 1996;64(5):1762-9.
1996: Ralf R Schumann; Dagmar Pfeil; Norbert Lamping; Carsten J Kirschning; G Scherzinger; P Schlag; Leonid Karawajew; F Herrmann
Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14.
Blood 1996;87(7):2805-14.
1996: Ralf R Schumann; T Nakarai; HJ Gruss; M A Brach; U von Arnim; Carsten J Kirschning; Leonid Karawajew; Wolf-Dieter Ludwig; J C Renauld; Jerome Ritz; F Herrmann
Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells.
Blood 1996;87(6):2419-27.
1996: Ernst Th Rietschel; Helmut Brade; Otto Holst; Lore Brade; Sven Müller-Loennies; Uwe Mamat; Ulrich Zähringer; F Beckmann; Ulrich Seydel; Klaus Brandenburg; Artur J Ulmer; T Mattern; Holger Heine; J Schletter; Harald Loppnow; Uwe Schönbeck; Hans-Dieter Flad; Sunna Hauschildt; U F Schade; F Di Padova; S Kusumoto; Ralf R Schumann
Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.
Current topics in microbiology and immunology 1996;216():39-81.
1995: Regine Landmann; F Scherer; Ralf R Schumann; S Link; Sebastiano Sansano; Werner Zimmerli
LPS directly induces oxygen radical production in human monocytes via LPS binding protein and CD14.
Journal of leukocyte biology 1995;57(3):440-9.
1995: Ralf R Schumann
Mechanisms of transcriptional activation of lipopolysaccharide binding protein (LBP).
Progress in clinical and biological research 1995;392():297-304.
1994: HJ Gruss; M A Brach; Ralf R Schumann; F Herrmann
Regulation of MCP-1/JE gene expression during monocytic differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):4907-14.
1994: Ralf R Schumann; E T Rietschel; Harald Loppnow
The role of CD14 and lipopolysaccharide-binding protein (LBP) in the activation of different cell types by endotoxin.
Medical microbiology and immunology 1994;183(6):279-97.
1994: H P Knopf; F Otto; R Engelhardt; Marina A Freudenberg; Chris Galanos; F Herrmann; Ralf R Schumann
Discordant adaptation of human peritoneal macrophages to stimulation by lipopolysaccharide and the synthetic lipid A analogue SDZ MRL 953. Down-regulation of TNF-alpha and IL-6 is paralleled by an up-regulation of IL-1 beta and granulocyte colony-stimulating factor expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):287-99.
1994: Ralf R Schumann; Norbert Lamping; Carsten J Kirschning; H P Knopf; A Hoess; F Herrmann
Lipopolysaccharide binding protein: its role and therapeutical potential in inflammation and sepsis.
Biochemical Society transactions 1994;22(1):80-2.
1992: Ralf R Schumann
Function of lipopolysaccharide (LPS)-binding protein (LBP) and CD14, the receptor for LPS/LBP complexes: a short review.
Research in immunology 1992;143(1):11-5.