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Walter Schunack

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Histamine Release

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Co-Publications
Name
62
Stark, Holger
56
Schwartz, Jean-Charles
49
Ligneau, Xavier
33
Arrang, Jean-Michel
31
Ganellin, Robin
27
Elz, Sigurd
23
Pertz, Heinz
16
Garbarg, Monique
13
Kiec-Kononowicz, Katarzyna
13
Rouleau, Agnès
10
Sasse, Astrid
10
Schlicker, Eberhard
10
Morini, Giovanni
10
Grandi, Daniela
9
Krause, Michael

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Publications

TOP 3
Lazewska Dorota; Wiecek Malgorzata; Ligneau Xavier; Kottke Tim; Weizel Lilia; Seifert Roland; Schunack Walter; Stark Holger; Kiec-Kononowicz Katarzyna
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.
Lazewska Dorota; Kuder Kamil; Ligneau Xavier; Camelin Jean-Claude; Schunack Walter; Stark Holger; Kiec-Kononowicz Katarzyna
Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.
Kuder K J; Ligneau X; Camelin J-C; Lazewska D; Schwartz J-C; Schunack W; Stark H; Kiec-Kononowicz K
Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands.

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All Publications

2009: Lazewska Dorota; Wiecek Malgorzata; Ligneau Xavier; Kottke Tim; Weizel Lilia; Seifert Roland; Schunack Walter; Stark Holger; Kiec-Kononowicz Katarzyna
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.
Bioorganic & medicinal chemistry letters 2009;19(23):6682-5.
2009: Lazewska Dorota; Kuder Kamil; Ligneau Xavier; Camelin Jean-Claude; Schunack Walter; Stark Holger; Kiec-Kononowicz Katarzyna
Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.
Bioorganic & medicinal chemistry 2009;17(8):3037-42.
2009: Kuder K J; Ligneau X; Camelin J-C; Lazewska D; Schwartz J-C; Schunack W; Stark H; Kiec-Kononowicz K
Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2009;58 Suppl 1():47-8.
2008: Weis Robert; Schweiger Klaus; Faist Johanna; Rajkovic Erich; Kungl Andreas J; Fabian Walter M F; Schunack Walter; Seebacher Werner
Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.
Bioorganic & medicinal chemistry 2008;16(24):10326-31.
2008: Levoin Nicolas; Calmels Thierry; Poupardin-Olivier Olivia; Labeeuw Olivier; Danvy Denis; Robert Philippe; Berrebi-Bertrand Isabelle; Ganellin C Robin; Schunack Walter; Stark Holger; Capet Marc
Refined docking as a valuable tool for lead optimization: application to histamine H3 receptor antagonists.
Archiv der Pharmazie 2008;341(10):610-23.
2008: Lazewska Dorota; Kuder Kamil; Ligneau Xavier; Schwartz Jean-Charles; Schunack Walter; Stark Holger; Kiec-Kononowicz Katarzyna
Piperidine variations in search for non-imidazole histamine H(3) receptor ligands.
Bioorganic & medicinal chemistry 2008;16(18):8729-36.
2008: Schunack Walter
[Not smoking, essential for healthy lungs]
Pharmazie in unserer Zeit 2008;37(6):494-9.
2007: Ligneau X; Perrin D; Landais L; Camelin J-C; Calmels T P G; Berrebi-Bertrand I; Lecomte J-M; Parmentier R; Anaclet C; Lin J-S; Bertaina-Anglade V; la Rochelle C Drieu; d'Aniello F; Rouleau A; Gbahou F; Arrang J-M; Ganellin C R; Stark H; Schunack W; Schwartz J-C
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.
The Journal of pharmacology and experimental therapeutics 2007;320(1):365-75.
2006: Schultheiss Gerhard; Hennig Britta; Schunack Walter; Prinz Gundula; Diener Martin
Histamine-induced ion secretion across rat distal colon: involvement of histamine H1 and H2 receptors.
European journal of pharmacology 2006;546(1-3):161-70.
2006: Schunack Walter
[Vitamin D3--a prodrug of different D3-hormones]
Medizinische Klinik (Munich, Germany : 1983) 2006;101 Suppl 1():20-4.
2006: Grandi Daniela; Schunack Walter; Morini Giuseppina
Epithelial cell proliferation is promoted by the histamine H(3) receptor agonist (R)-alpha-methylhistamine throughout the rat gastrointestinal tract.
European journal of pharmacology 2006;538(1-3):141-7.
2006: Lazewska Dorota; Ligneau Xavier; Schwartz Jean-Charles; Schunack Walter; Stark Holger; Kiec-Kononowicz Katarzyna
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(10):3522-9.
2005: Lazewska D; Kiec-Kononowicz K; Elz S; Pertz H H; Stark H; Schunack W
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the alkyl derivatives.
Die Pharmazie 2005;60(6):403-10.
2005: Uberti L; Silvotti L; Schunack W; Morini G
Effect of H3 receptor ligands on ethanol-induced damage in rat gastric mucosal cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S64-5.
2005: Apelt J; Grassmann S; Ligneau X; Pertz H H; Ganellin C R; Arrang J M; Schwartz J C; Schunack W; Stark H
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives.
Die Pharmazie 2005;60(2):97-106.
2005: Baldi Elisabetta; Bucherelli Corrado; Schunack Walter; Cenni Gabriele; Blandina Patrizio; Passani M Beatrice
The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat.
Neuropharmacology 2005;48(2):246-51.
2005: Fu Liang-Wu; Schunack Walter; Longhurst John C
Histamine contributes to ischemia-related activation of cardiac spinal afferents: role of H1 receptors and PKC.
Journal of neurophysiology 2005;93(2):713-22.
2004: Stark Holger; Kathmann Markus; Schlicker Eberhard; Schunack Walter; Schlegel Birgit; Sippl Wolfgang
Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists.
Mini reviews in medicinal chemistry 2004;4(9):965-77.
2004: Pertz Heinz H; Elz Sigurd; Schunack Walter
Structure-activity relationships of histamine H1-receptor agonists.
Mini reviews in medicinal chemistry 2004;4(9):935-40.
2004: Grassmann Sven; Apelt Joachim; Ligneau Xavier; Pertz Heinz H; Arrang Jean-Michel; Ganellin C Robin; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives.
Archiv der Pharmazie 2004;337(10):533-45.
2004: Sadek B; Elz S; Pertz H H; Stark H; Schunack W
Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 2():S109-15.
2004: Galeotti Nicoletta; Malmberg-Aiello Petra; Bartolini Alessandro; Schunack Walter; Ghelardini Carla
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.
Neuropharmacology 2004;47(2):295-303.
2004: Pelloux-Léon Nadia; Fkyerat Abdellatif; Piripitsi Antonia; Tertiuk Wasyl; Schunack Walter; Stark Holger; Garbarg Monique; Ligneau Xavier; Arrang Jean-Michel; Schwartz Jean-Charles; Ganellin C Robin
Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain.
Journal of medicinal chemistry 2004;47(12):3264-74.
2004: Meier Galina; Krause Michael; Hüls Annette; Ligneau Xavier; Pertz Heinz H; Arrang Jean-Michel; Ganellin C Robin; Schwartz Jean-Charles; Schunack Walter; Stark Holger
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists.
Journal of medicinal chemistry 2004;47(10):2678-87.
2004: Mikó Tibor; Ligneau Xavier; Pertz Heinz H; Arrang Jean-Michel; Ganellin C Robin; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry 2004;12(10):2727-36.
2004: Adami M; Coruzzi G; Guaita E; Schunack W; Kitbunnadaj R; Timmermann H
Neuronal histamine H(3) receptors mediate antisecretory effects in the rat isolated gastric fundus.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S25-6.
2004: Bruysters Martijn; Pertz Heinz H; Teunissen Aloys; Bakker Remko A; Gillard Michel; Chatelain Pierre; Schunack Walter; Timmerman Henk; Leurs Rob
Mutational analysis of the histamine H1-receptor binding pocket of histaprodifens.
European journal of pharmacology 2004;487(1-3):55-63.
2004: Valcheva-Kuzmanova Stefka V; Popova Petia B; Krasnaliev Ivan J; Galunska Bistra Tz; Belcheva Anna; Schunack Walter
Protective effect of BP 2-94, a histamine H3-receptor agonist prodrug, in a model of carbon tetrachloride-induced hepatotoxicity in rats.
Folia medica 2004;46(2):36-41.
2003: Govoni Marinella; Bakker Remko A; van de Wetering Ineke; Smit Martine J; Menge Wiro M B P; Timmerman Henk; Elz Sigurd; Schunack Walter; Leurs Rob
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
Journal of medicinal chemistry 2003;46(26):5812-24.
2003: Menghin Sonja; Pertz Heinz H; Kramer Kai; Seifert Roland; Schunack Walter; Elz Sigurd
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.
Journal of medicinal chemistry 2003;46(25):5458-70.
2003: Pierpaoli S; Marzocca C; Bello M G; Schunack W; Mannaioni P F; Masini E
Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(9):390-6.
2003: Gbahou Florence; Rouleau Agnès; Morisset Séverine; Parmentier Régis; Crochet Sylvain; Lin Jian-Sheng; Ligneau Xavier; Tardivel-Lacombe Joël; Stark Holger; Schunack Walter; Ganellin C Robin; Schwartz Jean-Charles; Arrang Jean-Michel
Protean agonism at histamine H3 receptors in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):11086-91.
2003: Seifert Roland; Wenzel-Seifert Katharina; Burckstummer Tilmann; Pertz Heinz H; Schunack Walter; Dove Stefan; Buschauer Armin; Elz Sigurd
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1104-15.
2003: Grassmann Sven; Apelt Joachim; Sippl Wolfgang; Ligneau Xavier; Pertz Heinz H; Zhao Yuan Hui; Arrang Jean Michel; Ganellin C Robin; Schwartz Jean Charles; Schunack Walter; Stark Holger
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities.
Bioorganic & medicinal chemistry 2003;11(10):2163-74.
2003: Carman-Krzan Marija; Bavec Aljosa; Zorko Matjaz; Schunack Walter
Molecular characterization of specific H1-receptor agonists histaprodifen and its Nalpha-substituted analogues on bovine aortic H1-receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(5):538-46.
2003: Malmberg-Aiello P; Ipponi A; Blandina P; Bartolini L; Schunack W
Pro-cognitive effect of a selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, in the rat object recognition test.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52 Suppl 1():S33-4.
2003: Mikó Tibor; Ligneau Xavier; Pertz Heinz H; Ganellin C Robin; Arrang Jean-Michel; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.
Journal of medicinal chemistry 2003;46(8):1523-30.
2003: Liedtke Susanna; Flau Karsten; Kathmann Markus; Schlicker Eberhard; Stark Holger; Meier Galina; Schunack Walter
Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(1):43-50.
2003: Schunack Walter; Schubert-Zsilavecz Manfred
[Regarding public health there is no doubt that in Germany and Europe that it is driven by economic considerations]
Pharmazie in unserer Zeit 2003;32(6):445.
2003: Schunack Walter
[Cardiovascular risk factor reduction. Cholesterol absorption inhibitors: a new action principle]
Pharmazie in unserer Zeit 2003;32(6):498-502.
2003: Schwartz J C; Morisset S; Rouleau A; Ligneau X; Gbahou F; Tardivel-Lacombe J; Stark H; Schunack W; Ganellin C R; Arrang J M
Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.
Journal of neural transmission. Supplementum 2003;(64):1-16.
2002: Lazewska D; Kiec-Kononowicz K; Pertz H H; Elz S; Stark H; Schunack W
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the influence of the additional ether functionality.
Die Pharmazie 2002;57(12):791-5.
2002: Garnham Byron M; Fitzpatrick-Wong Shirley; Schunack Walter; Nürnberg Bernd; Sorrentino Giuseppe; Parkinson Fiona E; Kanfer Julian N; Sitar Daniel S
Activation of phospholipases A2 and D of a human neuroblastoma cell line (LA-N-2) by N-dodecyl-L-lysine amide (compound 24), a putative G protein activator: characteristics of inhibition by (-)-nicotine.
Neurochemical research 2002;27(12):1613-8.
2002: Morini Giuseppina; Grandi Daniela; Schunack Walter
Ligands for histamine H(3) receptors modulate cell proliferation and migration in rat oxyntic mucosa.
British journal of pharmacology 2002;137(2):237-44.
2002: Sasse Astrid; Ligneau Xavier; Rouleau Agnès; Elz Sigurd; Ganellin C Robin; Arrang Jean-Michel; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties.
Journal of medicinal chemistry 2002;45(18):4000-10.
2002: Meier Galina; Ligneau Xavier; Pertz Heinz H; Ganellin C Robin; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists.
Bioorganic & medicinal chemistry 2002;10(8):2535-42.
2002: Bacciottini Lucia; Passani Maria Beatrice; Giovannelli Lisa; Cangioli Iacopo; Mannaioni Pier Francesco; Schunack Walter; Blandina Patrizio
Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat.
The European journal of neuroscience 2002;15(10):1669-80.
2002: Pozzoli Cristina; Todorov Simeon; Schunack Walter; Timmerman Henk; Coruzzi Gabriella; Poli Enzo
Role of histamine H3 receptors in control of mouse intestinal motility in vivo and in vitro: comparison with alpha2-adrenoceptors.
Digestive diseases and sciences 2002;47(5):1065-72.
2002: Grassmann Sven; Sadek Bassem; Ligneau Xavier; Elz Sigurd; Ganellin C Robin; Arrang Jean-Michel; Schwartz Jean-Charles; Stark Holger; Schunack Walter
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(4):367-78.
2002: Morini G; Timmerman H; Schunack W; Grandi D
Agonists for the histamine H3-receptor differ in their gastroprotective activity in the rat.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51 Suppl 1():S75-6.
2002: Wiecek M; Kiec-Kononowicz K; Sasse A; Ligneau X; Schwartz J C; Schunack W; Stark H
Impact of lipophilicity on the pharmacological properties of histamine H3-receptor antagonists of the cycloalkyl carbamate class.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51 Suppl 1():S71-2.
2002: Coruzzi G; Poli E; Pozzoli C; Nosalova V; Grandi D; Lazzaretti M; Schunack W
Effect of BP 2.94, a histamine H3-receptor agonist prodrug, on different models of colitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51 Suppl 1():S31-2.
2002: Breitweg-Lehmann Evelyn; Czupalla Cornelia; Storm Rüdiger; Kudlacek Oliver; Schunack Walter; Freissmuth Michael; Nürnberg Bernd
Activation and inhibition of G proteins by lipoamines.
Molecular pharmacology 2002;61(3):628-36.
2002: Apelt Joachim; Ligneau Xavier; Pertz Heinz H; Arrang Jean-Michel; Ganellin C Robin; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.
Journal of medicinal chemistry 2002;45(5):1128-41.
2002: Malmberg-Aiello Petra; Ipponi Alessandra; Bartolini Alessandro; Schunack Walter
Mouse light/dark box test reveals anxiogenic-like effects by activation of histamine H1 receptors.
Pharmacology, biochemistry, and behavior 2002;71(1-2):313-8.
2001: Lazewska D; Kiec-Kononowicz K; Pertz H H; Stark H; Schunack W; Elz S
Piperidine-containing histamine H3-receptor antagonists of the carbamate series: variation of the spacer length.
Die Pharmazie 2001;56(12):927-32.
2001: Schwartz J C; Morisset S; Rouleau A; Tardivel-Lacombe J; Gbahou F; Ligneau X; Héron A; Sasse A; Stark H; Schunack W; Ganellin R C; Arrang J M
Application of genomics to drug design: the example of the histamine H3 receptor.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2001;11(6):441-8.
2001: Krause M; Stark H; Schunack W
Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist.
Current medicinal chemistry 2001;8(11):1329-40.
2001: Schlicker E; Kozlowska H; Kwolek G; Malinowska B; Kramer K; Pertz H H; Elz S; Schunack W
Novel histaprodifen analogues as potent histamine H1-receptor agonists in the pithed and in the anaesthetized rat.
Naunyn-Schmiedeberg's archives of pharmacology 2001;364(1):14-20.
2001: Meier G; Apelt J; Reichert U; Grassmann S; Ligneau X; Elz S; Leurquin F; Ganellin C R; Schwartz J C; Schunack W; Stark H
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(3):249-59.
2001: Morini G; Grandi D; Sasse A; Stark H; Schunack W
Gastroprotective activity of the novel histamine H3-receptor agonist FUB 407.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50 Suppl 2():S116-7.
2001: Morini G; Guaita E; Coruzzi G; Grandi D; Schunack W
Gastroprotection by (R)-alpha-methylhistamine: involvement of nitric oxide?
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50 Suppl 2():S114-5.
2001: Nosalova V; Cerna S; Schunack W; Grandi D; Coruzzi G
Effects of (R)alpha-methylhistamine on experimental colitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50 Suppl 2():S108-9.
2001: Nickel T; Bauer U; Schlicker E; Kathmann M; Göthert M; Sasse A; Stark H; Schunack W
Novel histamine H(3)-receptor antagonists and partial agonists with a non-aminergic structure.
British journal of pharmacology 2001;132(8):1665-72.
2001: Stark H; Sippl W; Ligneau X; Arrang J M; Ganellin C R; Schwartz J C; Schunack W
Different antagonist binding properties of human and rat histamine H3 receptors.
Bioorganic & medicinal chemistry letters 2001;11(7):951-4.
2001: Sasse A; Ligneau X; Sadek B; Elz S; Pertz H H; Ganellin C R; Arrang J M; Schwartz J C; Schunack W; Stark H
Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands.
Archiv der Pharmazie 2001;334(2):45-52.
2001: Sasse A; Schunack W; Stark H
Separation of chiral 4-substituted imidazole derivatives by cyclodextrin-modified capillary electrophoresis.
Biomedical chromatography : BMC 2001;15(1):25-30.
2001: Stark H; Krause M; Rouleau A; Garbarg M; Schwartz J C; Schunack W
Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine.
Bioorganic & medicinal chemistry 2001;9(1):191-8.
2001: Stark H; Arrang J M; Ligneau X; Garbarg M; Ganellin C R; Schwartz J C; Schunack W
The histamine H3 receptor and its ligands.
Progress in medicinal chemistry 2001;38():279-308.
2000: Morisset S; Rouleau A; Ligneau X; Gbahou F; Tardivel-Lacombe J; Stark H; Schunack W; Ganellin C R; Schwartz J C; Arrang J M
High constitutive activity of native H3 receptors regulates histamine neurons in brain.
Nature 2000;408(6814):860-4.
2000: Ligneau X; Morisset S; Tardivel-Lacombe J; Gbahou F; Ganellin C R; Stark H; Schunack W; Schwartz J C; Arrang J M
Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.
British journal of pharmacology 2000;131(7):1247-50.
2000: Stark H; Ligneau X; Sadek B; Ganellin C R; Arrang J M; Schwartz J C; Schunack W
Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists.
Bioorganic & medicinal chemistry letters 2000;10(20):2379-82.
2000: Stark H; Sadek B; Krause M; Hüls A; Ligneau X; Ganellin C R; Arrang J M; Schwartz J C; Schunack W
Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds.
Journal of medicinal chemistry 2000;43(21):3987-94.
2000: Rouleau A; Stark H; Schunack W; Schwartz J C
Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug.
The Journal of pharmacology and experimental therapeutics 2000;295(1):219-25.
2000: Sasse A; Sadek B; Ligneau X; Elz S; Pertz H H; Luger P; Ganellin C R; Arrang J M; Schwartz J C; Schunack W; Stark H
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency.
Journal of medicinal chemistry 2000;43(17):3335-43.
2000: Malmberg-Aiello P; Ipponi A; Bartolini A; Schunack W
Antiamnesic effect of metoprine and of selective histamine H(1) receptor agonists in a modified mouse passive avoidance test.
Neuroscience letters 2000;288(1):1-4.
2000: Kiec-Kononowicz K; Wiecek M; Sasse A; Ligneau X; Elz S; Ganellin C R; Schwartz J C; Stark H; Schunack W
Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity.
Die Pharmazie 2000;55(5):349-55.
2000: Sasse A; Stark H; Ligneau X; Elz S; Reidemeister S; Ganellin C R; Schwartz J C; Schunack W
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors.
Bioorganic & medicinal chemistry 2000;8(5):1139-49.
2000: Bacciottini L; Giovannelli L; Passani M B; Schunack W; Mannaioni P F; Blandina P
Ciproxifan and cimetidine modulate c-fos expression in septal neurons, and acetylcholine release from hippocampus of freely moving rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2000;49 Suppl 1():S41-2.
2000: Morini G; Grandi D; Stark H; Schunack W
Histamine H(3)-receptor antagonists inhibit gastroprotection by (R)-alpha-methylhistamine in the rat.
British journal of pharmacology 2000;129(8):1597-600.
2000: Elz S; Kramer K; Pertz H H; Detert H; ter Laak A M; Kühne R; Schunack W
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.
Journal of medicinal chemistry 2000;43(6):1071-84.
2000: Reidemeister S; Stark H; Ligneau X; Ganellin C R; Schwartz J C; Schunack W
Substituted N-phenylcarbamates as histamine H3 receptor antagonists with improved in vivo potency.
Die Pharmazie 2000;55(2):83-6.
2000: Bertaccini G; Morini G; Coruzzi G; Schunack W
Histamine H3 receptors in the guinea pig ileum: evidence for a postjunctional location.
Journal of physiology, Paris 2000;94(1):1-4.
2000: Elz S; Kramer K; Leschke C; Schunack W
Ring-substituted histaprodifen analogues as partial agonists for histamine H(1) receptors: synthesis and structure-activity relationships.
European journal of medicinal chemistry 2000;35(1):41-52.
1999: Sasse A; Stark H; Reidemeister S; Hüls A; Elz S; Ligneau X; Ganellin C R; Schwartz J C; Schunack W
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity.
Journal of medicinal chemistry 1999;42(20):4269-74.
1999: Morini G; Grandi D; Bertaccini G; Leschke C; Schunack W
Stereoselective inhibition of ethanol-induced gastric lesions in the rat by the H(3)-receptor agonist (R)-alpha-methylhistamine and its (S)-configured isomer.
Pharmacology 1999;59(4):192-200.
1999: Windhorst A D; Timmerman H; Klok R P; Custers F G; Menge W M; Leurs R; Stark H; Schunack W; Gielen E G; van Kroonenburgh M J; Herscheid J D
Radiosynthesis and biodistribution of 123I-labeled antagonists of the histamine H3 receptor as potential SPECT ligands.
Nuclear medicine and biology 1999;26(6):651-9.
1999: Sasse A; Kiec-Kononowicz K; Stark H; Motyl M; Reidemeister S; Ganellin C R; Ligneau X; Schwartz J C; Schunack W
Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity.
Journal of medicinal chemistry 1999;42(4):593-600.
1998: Ganellin C R; Leurquin F; Piripitsi A; Arrang J M; Garbarg M; Ligneau X; Schunack W; Schwartz J C
Synthesis of potent non-imidazole histamine H3-receptor antagonists.
Archiv der Pharmazie 1998;331(12):395-404.
1998: Kathmann M; Schlicker E; Marr I; Werthwein S; Stark H; Schunack W
Ciproxifan and chemically related compounds are highly potent and selective histamine H3-receptor antagonists.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(6):623-7.
1998: Ligneau X; Lin J; Vanni-Mercier G; Jouvet M; Muir J L; Ganellin C R; Stark H; Elz S; Schunack W; Schwartz J
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1998;287(2):658-66.
1998: Krause M; Ligneau X; Stark H; Garbarg M; Schwartz J C; Schunack W
4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity.
Journal of medicinal chemistry 1998;41(21):4171-6.
1998: Kramer K; Elz S; Pertz H H; Schunack W
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
Bioorganic & medicinal chemistry letters 1998;8(18):2583-8.
1998: Stark H; Ligneau X; Arrang J M; Schwartz J C; Schunack W
General construction pattern of histamine H3-receptor antagonists: change of a paradigm.
Bioorganic & medicinal chemistry letters 1998;8(15):2011-6.
1998: Wolf C; Schulze F R; Buschauer A; Schunack W
Combined histamine H1/H2 receptor antagonists: part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;6(3):187-96.
1998: Schulze F R; Buschauer A; Schunack W
Combined histamine H1/H2 receptor antagonists: part I. Pharmacological hybrids with pheniramine- and roxatidine-like substructures.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;6(3):177-86.
1998: Stark H; Hüls A; Ligneau X; Purand K; Pertz H; Arrang J M; Schwartz J C; Schunack W
Development of FUB 181, a selective histamine H3-receptor antagonist of high oral in vivo potency with 4-(omega-(arylalkyloxy)alkyl)-1H-imidazole structure.
Archiv der Pharmazie 1998;331(6):211-8.
1998: Lamberti C; Ipponi A; Bartolini A; Schunack W; Malmberg-Aiello P
Antidepressant-like effects of endogenous histamine and of two histamine H1 receptor agonists in the mouse forced swim test.
British journal of pharmacology 1998;123(7):1331-6.
1998: Timm J; Marr I; Werthwein S; Elz S; Schunack W; Schlicker E
H2 receptor-mediated facilitation and H3 receptor-mediated inhibition of noradrenaline release in the guinea-pig brain.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(3):232-9.
1998: Malmberg-Aiello P; Lamberti C; Ipponi A; Bartolini A; Schunack W
Evidence for hypernociception induction following histamine H1 receptor activation in rodents.
Life sciences 1998;63(6):463-76.
1997: Leschke C; Storm R; Breitweg-Lehmann E; Exner T; Nürnberg B; Schunack W
Alkyl-substituted amino acid amides and analogous di- and triamines: new non-peptide G protein activators.
Journal of medicinal chemistry 1997;40(19):3130-9.
1997: Stark H; Hüls A; Ligneau X; Arrang J M; Schwartz J C; Schunack W
Search for novel leads for histamine H3-receptor antagonists: oxygen-containing derivatives.
Die Pharmazie 1997;52(7):495-500.
1997: Stark H; Ligneau X; Lipp R; Arrang J M; Schwartz J C; Schunack W
Search for novel leads for histamine H3-receptor antagonists: amine derivatives.
Die Pharmazie 1997;52(6):419-23.
1997: Rouleau A; Garbarg M; Ligneau X; Mantion C; Lavie P; Advenier C; Lecomte J M; Krause M; Stark H; Schunack W; Schwartz J C
Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1085-94.
1997: Mannaioni P F; Bello M G; Di Bello M G; Mirabella C; Gai P; Schunack W; Masini E
Interaction between histamine and nitric oxide in rat mast cells and in isolated guinea pig hearts.
International archives of allergy and immunology 1997;113(1-3):297-9.
1997: Carman-Krzan M; Krzan M; Schunack W
Pharmacological properties of cardiovascular histamine H1 receptor binding sites: characterisation with 2-phenylhistamines.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(4):431-7.
1997: Belcheva A; Marazova K; Lozeva V; Schunack W
Effects of (R)-alpha-methylhistamine and its prodrug BP 2.94 on gastric mucosal lesions in cold/restraint stressed rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 1():S113-4.
1997: Morini G; Grandi D; Krause M; Schunack W
Gastric mucosal injury by nonsteroidal anti-inflammatory drugs is reduced by (R)-alpha-methylhistamine and its pro-drugs in the rat.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 1():S101-2.
1997: Mannaioni P F; Bello M G; Di Bello M G; Schunack W; Masini E
Histamine up-regulates the generation of nitric oxide, and nitric oxide down-regulates the release of histamine in cardiovascular preparations.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 1():S97-8.
1996: Krause M; Rouleau A; Stark H; Garbarg M; Schwartz J C; Schunack W
Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine: from alkylaryl to substituted diaryl derivatives.
Die Pharmazie 1996;51(10):720-6.
1996: Hüls A; Purand K; Stark H; Reidemeister S; Ligneau X; Arrang J M; Schwartz J C; Schunack W
Novel histamine H3-receptor antagonists with benzyl ether structure or related moieties: synthesis and structure-activity relationships.
Archiv der Pharmazie 1996;329(8-9):379-85.
1996: Schlicker E; Kathmann M; Bitschnau H; Marr I; Reidemeister S; Stark H; Schunack W
Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: evidence for H3 receptor heterogeneity?
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(5):482-8.
1996: Krause M; Rouleau A; Stark H; Luger P; Garbarg M; Schwartz J C; Schunack W
New potent azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine containing a heteroarylphenyl partial structure.
Archiv der Pharmazie 1996;329(4):209-15.
1996: Stark H; Purand K; Ligneau X; Rouleau A; Arrang J M; Garbarg M; Schwartz J C; Schunack W
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity.
Journal of medicinal chemistry 1996;39(5):1157-63.
1996: Stark H; Purand K; Hüls A; Ligneau X; Garbarg M; Schwartz J C; Schunack W
[125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor.
Journal of medicinal chemistry 1996;39(6):1220-6.
1996: Wolf C; Schunack W
Synthesis and pharmacology of combined histamine H1-/H2-receptor antagonists containing diphenhydramine and cyproheptadine derivatives.
Archiv der Pharmazie 1996;329(2):87-94.
1996: Detert H; Seifert R; Schunack W
Cationic amphiphiles with G-protein-stimulatory activity: studies on the role of the basic domain in the activation process.
Die Pharmazie 1996;51(2):67-72.
1995: Krause M; Rouleau A; Stark H; Luger P; Lipp R; Garbarg M; Schwart J C; Schunack W
Synthesis, X-ray crystallography, and pharmacokinetics of novel azomethine prodrugs of (R)-alpha-methylhistamine: highly potent and selective histamine H3 receptor agonists.
Journal of medicinal chemistry 1995;38(20):4070-9.
1995: Schlicker E; Pertz H; Bitschnau H; Purand K; Kathmann M; Elz S; Schunack W
Effects of iodoproxyfan, a potent and selective histamine H3 receptor antagonist, on alpha 2 and 5-HT3 receptors.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44(7):296-300.
1995: Kiec-Kononowicz K; Ligneau X; Schwartz J C; Schunack W
Pyrazoles as potential histamine H3-receptor antagonists.
Archiv der Pharmazie 1995;328(5):469-72.
1995: Kiec-Kononowicz K; Ligneau X; Stark H; Schwartz J C; Schunack W
Azines and diazines as potential histamine H3-receptor antagonists.
Archiv der Pharmazie 1995;328(5):445-50.
1995: Leschke C; Elz S; Garbarg M; Schunack W
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
Journal of medicinal chemistry 1995;38(8):1287-94.
1995: Hagelüken A; Grünbaum L; Klinker J F; Nürnberg B; Harhammer R; Schultz G; Leschke C; Schunack W; Seifert R
Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells.
Biochemical pharmacology 1995;49(7):901-914.
1995: Hagelüken A; Nürnberg B; Harhammer R; Grünbaum L; Schunack W; Seifert R
The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins.
Molecular pharmacology 1995;47(2):234-40.
1994: Monti J M; Jantos H; Leschke C; Elz S; Schunack W
The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1994;4(4):459-62.
1994: Ligneau X; Garbarg M; Vizuete M L; Diaz J; Purand K; Stark H; Schunack W; Schwartz J C
[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors.
The Journal of pharmacology and experimental therapeutics 1994;271(1):452-9.
1994: Schlicker E; Kathmann M; Reidemeister S; Stark H; Schunack W
Novel histamine H3 receptor antagonists: affinities in an H3 receptor binding assay and potencies in two functional H3 receptor models.
British journal of pharmacology 1994;112(4):1043-8.
1994: Schulze F R; Alisch R A; Buschauer A; Schunack W
[Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures]
Archiv der Pharmazie 1994;327(7):455-62.
1994: Schunack W; Stark H
Design of histamine H3-receptor agonists and antagonists.
European journal of drug metabolism and pharmacokinetics 1994;19(3):173-8.
1994: Hagelüken A; Grünbaum L; Nürnberg B; Harhammer R; Schunack W; Seifert R
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Biochemical pharmacology 1994;47(10):1789-95.
1994: Seifert R; Hagelüken A; Höer A; Höer D; Grünbaum L; Offermanns S; Schwaner I; Zingel V; Schunack W; Schultz G
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.
Molecular pharmacology 1994;45(4):578-86.
1994: Kleine-Tebbe J; Josties C; Frank G; Stalleicken D; Buschauer A; Schunack W; Kunkel G; Czarnetzki B
Inhibition of IgE- and non-IgE-mediated histamine release from human basophil leukocytes in vitro by a histamine H1-antagonist, desethoxycarbonyl-loratadine.
The Journal of allergy and clinical immunology 1994;93(2):494-500.
1992: Lipp R; Arrang J M; Garbarg M; Luger P; Schwartz J C; Schunack W
Synthesis, absolute configuration, stereoselectivity, and receptor selectivity of (alpha R, beta S)-alpha,beta-dimethylhistamine, a novel high potent histamine H3 receptor agonist.
Journal of medicinal chemistry 1992;35(23):4434-41.
1992: Seifert R; Höer A; Offermanns S; Buschauer A; Schunack W
Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue.
Molecular pharmacology 1992;42(2):227-34.
1992: Sellier C; Elz S; Buschauer A; Schunack W
The effect of lipophilic substituents on the H2-histaminergic activity of some close analogues of impromidine.
Archiv der Pharmazie 1992;325(8):471-6.
1992: Kleine-Tebbe J; Wicht L; Gagné H; Friese A; Schunack W; Schudt C; Kunkel G
Inhibition of IgE-mediated histamine release from human peripheral leukocytes by selective phosphodiesterase inhibitors.
Agents and actions 1992;36(3-4):200-6.
1992: Hirschfeld J; Buschauer A; Elz S; Schunack W; Ruat M; Traiffort E; Schwartz J C
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Journal of medicinal chemistry 1992;35(12):2231-8.
1992: Kleine-Tebbe J; Buschauer A; Friese A; Schunack W; Kunkel G
Modulation of IgE-mediated histamine release from human leukocytes by a new class of histamine H2-agonists.
Agents and actions 1992;35(3-4):185-91.
1991: Lipp R; Arrang J M; Buschmann J; Garbarg M; Luger P; Schunack W; Schwartz J C
Novel chiral H3-receptor agonists.
Agents and actions. Supplements 1991;33():277-82.
1991: Arrang J M; Garbarg M; Schwartz J C; Lipp R; Stark H; Schunack W; Lecomte J M
The histamine H3-receptor: pharmacology, roles and clinical implications studied with agonists.
Agents and actions. Supplements 1991;33():55-67.
1990: Schlicker E; Schunack W; Göthert M
Histamine H3 receptor-mediated inhibition of noradrenaline release in pig retina discs.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(5):497-501.
1990: Kleine-Tebbe J; Schramm J; Bolz M; Lipp R; Schunack W; Kunkel G
Influence of histamine H3-antagonists on human leukocytes.
Agents and actions 1990;30(1-2):137-9.
1990: Arrang J M; Roy J; Morgat J L; Schunack W; Schwartz J C
Histamine H3 receptor binding sites in rat brain membranes: modulations by guanine nucleotides and divalent cations.
European journal of pharmacology 1990;188(4-5):219-27.
1990: Ruat M; Traiffort E; Bouthenet M L; Schwartz J C; Hirschfeld J; Buschauer A; Schunack W
Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1658-62.
1989: Schunack W
Pharmacology of H2-receptor antagonists: an overview.
The Journal of international medical research 1989;17 Suppl 1():9A-16A.
1987: Schunack W
What are the differences between the H2-receptor antagonists?
Alimentary pharmacology & therapeutics 1987;1 Suppl 1():493S-503S.

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