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Ina Schuppe-Koistinen

Research Profile

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Chemicals & Drugs

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Oligonucleotide Array Sequence Analysis

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Drug-Induced Liver Injury

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Publications

TOP 3
Ingalill Rafter; Ina Schuppe-Koistinen; Lovisa Strömmer; Hannele Yki-Järvinen; Håkan B Andersson; Ian Cotgreave; Ewa Ehrenborg; Björn Ekblom; Truls Gråberg; Ray W Kim; Anna Kotronen; C Mikael Mattson; B Glinghammar
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.
Kim Boekelheide; Ina Schuppe-Koistinen
SOT/EUROTOX debate: biomarkers from blood and urine will replace traditional histopathological evaluation to determine adverse responses.
Lee Faulkner; Klara Martinsson; Dean J Naisbitt; Helen Powell; Anahi Santoyo-Castelazo; Ina Schuppe-Koistinen; Jonathan D Tugwood; Karin Cederbrant; B Kevin Park
The development of in vitro culture methods to characterize primary T-cell responses to drugs.

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All Publications

2012: Ingalill Rafter; Ina Schuppe-Koistinen; Lovisa Strömmer; Hannele Yki-Järvinen; Håkan B Andersson; Ian Cotgreave; Ewa Ehrenborg; Björn Ekblom; Truls Gråberg; Ray W Kim; Anna Kotronen; C Mikael Mattson; B Glinghammar
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.
International journal of molecular medicine 2012;30(5):1241-9.
2012: Kim Boekelheide; Ina Schuppe-Koistinen
SOT/EUROTOX debate: biomarkers from blood and urine will replace traditional histopathological evaluation to determine adverse responses.
Toxicological sciences : an official journal of the Society of Toxicology 2012;129(2):249-55.
2012: Lee Faulkner; Klara Martinsson; Dean J Naisbitt; Helen Powell; Anahi Santoyo-Castelazo; Ina Schuppe-Koistinen; Jonathan D Tugwood; Karin Cederbrant; B Kevin Park
The development of in vitro culture methods to characterize primary T-cell responses to drugs.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(1):150-8.
2012: Helmi M'Kada; Mona Munteanu; Yen Ngo; Hugo Perazzo; Charles Pierrot-Deseilligny; Thierry Poynard; Nittia Ramanujam; Vlad Ratziu; Yves Samson; Ina Schuppe-Koistinen; Patrick Tilleul; Zahir Amoura; Dominique Bonnefont-Rousselot; Philippe Boulogne; François Bricaire; Olivier Lyon Caen; Pierre Coriat; Olivier Deckmyn; Jean Yves Delattre; Vincent Nicolas Delpech; Bruno Fautrel; Serge Herson; Françoise Imbert-Bismut; David Khayat; Véronique Leblond
Real time identification of drug-induced liver injury (DILI) through daily screening of ALT results: a prospective pilot cohort study.
PloS one 2012;7(8):e42418.
2011: Maja Neiman; Pierre R Dönnes; Stephan Hanschke; Jesper J Hedberg; Ralf Schindler; Ina Schuppe-Koistinen; Jochen M Schwenk; Mathias Uhlén; Peter Nilsson
Plasma profiling reveals human fibulin-1 as candidate marker for renal impairment.
Journal of proteome research 2011;10(11):4925-34.
2011: Helmi M'Kada; Mona Munteanu; Yen Ngo; Hugo Perazzo; Thierry Poynard; Nittia Ramanujam; Vlad Ratziu; Ina Schuppe-Koistinen; Bernard Souberbielle; Dominique Bonnefont-Rousselot; Françoise Imbert-Bismut
What are the best reference values for a normal serum alanine transaminase activity (ALT)? Impact on the presumed prevalence of drug induced liver injury (DILI).
Regulatory toxicology and pharmacology : RTP 2011;60(3):290-5.
2011: Katja Matheis; Michael Merz; Teresa Padro; Hannes Planatscher; Annamaria Rossi; Nicole Schneiderhan-Marra; Ina Schuppe-Koistinen; Peter Thomann; Jean-Marc Vidal; Christiane Andriamandroso; Nadir Arber; Lina Badimon; Xavier Benain; Kaïdre Bendjama; Isabelle Clavier; Peter Colman; Hüseyin Firat; Jens Goepfert; Steve Hall; Thomas Joos; Sarah Kraus; Axel Kretschmer; David Laurie; Béatrice Molac
A generic operational strategy to qualify translational safety biomarkers.
Drug discovery today 2011;16(13-14):600-8.
2010: Samer Sourial; Lydia Searchfield; Ina Schuppe-Koistinen; Graham R Betton; Daniela Riccardi; Sally A Price
Application of Dolichos biflorus in immunoassay detection of kidney collecting duct biomarkers.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010;15(5):424-35.
2010: Erik Alm; Ralf Torgrip; K Magnus Aberg; Ina Schuppe-Koistinen; Johan Lindberg
Time-resolved biomarker discovery in 1H-NMR data using generalized fuzzy Hough transform alignment and parallel factor analysis.
Analytical and bioanalytical chemistry 2010;396(5):1681-9.
2009: Ulf Andersson; Johan Lindberg; Shunghuang Wang; Raji Balasubramanian; Maritha Marcusson-Ståhl; Mira Hannula; Chenhui Zeng; Peter J Juhasz; Johan Kolmert; Jonas Bäckström; Lars Nord; Kerstin Nilsson; Steve Martin; Björn Glinghammar; Karin Cederbrant; Ina Schuppe-Koistinen
A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2009;14(8):572-86.
2009: Erik Alm; Ralf Torgrip; K Magnus Aberg; Ina Schuppe-Koistinen; Johan Lindberg
A solution to the 1D NMR alignment problem using an extended generalized fuzzy Hough transform and mode support.
Analytical and bioanalytical chemistry 2009;395(1):213-23.
2009: Angelica Butura; Kerstin Nilsson; Kengathevy Morgan; Timothy R Morgan; Samuel W French; Inger Johansson; Ina Schuppe-Koistinen; Magnus Ingelman-Sundberg
The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model.
Journal of hepatology 2009;50(3):572-83.
2008: K Magnus Aberg; Ralf Torgrip; Johan Kolmert; Ina Schuppe-Koistinen; Johan Lindberg
Feature detection and alignment of hyphenated chromatographic-mass spectrometric data. Extraction of pure ion chromatograms using Kalman tracking.
Journal of chromatography. A 2008;1192(1):139-46.
2008: Aram Adourian; Ezra Jennings; Raji Balasubramanian; Wade M Hines; Doris Damian; Thomas N Plasterer; Clary B Clish; Paul Stroobant; Robert McBurney; Elwin Verheij; Ivana Bobeldijk; Jan van der Greef; Johan Lindberg; Kerstin Kenne; Ulf Andersson; Heike Hellmold; Kerstin Nilsson; Hugh Salter; Ina Schuppe-Koistinen
Correlation network analysis for data integration and biomarker selection.
Molecular bioSystems 2008;4(3):249-59.
2007: Eleni Skordi; Ivan K S Yap; Sandrine P Claus; Francois-Pierre Martin; Olivier Cloarec; Johan Lindberg; Ina Schuppe-Koistinen; Elaine Holmes; Jeremy K Nicholson
Analysis of time-related metabolic fluctuations induced by ethionine in the rat.
Journal of proteome research 2007;6(12):4572-81.
2007: Leonard Csenki; Erik Alm; Ralf Torgrip; K Magnus Aberg; Lars I Nord; Ina Schuppe-Koistinen; Johan Lindberg
Proof of principle of a generalized fuzzy Hough transform approach to peak alignment of one-dimensional 1H NMR data.
Analytical and bioanalytical chemistry 2007;389(3):875-85.
2007: Elin Thysell; Elin Pohjanen; Johan Lindberg; Ina Schuppe-Koistinen; Thomas Moritz; Pär Jonsson; Henrik Antti
Reliable profile detection in comparative metabolomics.
Omics : a journal of integrative biology 2007;11(2):209-24.
2006: Pär Jonsson; Elin Sjövik Johansson; Anna Wuolikainen; Johan Lindberg; Ina Schuppe-Koistinen; Miyako Kusano; Michael Sjöström; Johan Trygg; Thomas Moritz; Henrik Antti
Predictive metabolite profiling applying hierarchical multivariate curve resolution to GC-MS data--a potential tool for multi-parametric diagnosis.
Journal of proteome research 2006;5(6):1407-14.
2006: Ragnar Stolt; Ralf Torgrip; Johan Lindberg; Leonard Csenki; Johan Kolmert; Ina Schuppe-Koistinen; Sven P Jacobsson
Second-order peak detection for multicomponent high-resolution LC/MS data.
Analytical chemistry 2006;78(4):975-83.
2005: Helena Idborg; Leila Zamani; Per-Olof Edlund; Ina Schuppe-Koistinen; Sven P Jacobsson
Metabolic fingerprinting of rat urine by LC/MS Part 2. Data pretreatment methods for handling of complex data.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;828(1-2):14-20.
2005: Helena Idborg; Leila Zamani; Per-Olof Edlund; Ina Schuppe-Koistinen; Sven P Jacobsson
Metabolic fingerprinting of rat urine by LC/MS Part 1. Analysis by hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;828(1-2):9-13.
2005: David Brott; Sarah Gould; H Jones; J Schofield; H Prior; J P Valentin; S Bjurstrom; Kerstin Kenne; Ina Schuppe-Koistinen; Anne M Katein; L Foster-Brown; Graham R Betton; Rudy Richardson; G Evans; Calvert Louden
Biomarkers of drug-induced vascular injury.
Toxicology and applied pharmacology 2005;207(2 Suppl):441-5.
2004: Angelica Butura; Inger Johansson; Kerstin Nilsson; Lars Wärngård; Magnus Ingelman-Sundberg; Ina Schuppe-Koistinen
Differentiation of human hepatoma cells during confluence as revealed by gene expression profiling.
Biochemical pharmacology 2004;67(7):1249-58.
2003: Helena Idborg-Björkman; Per-Olof Edlund; Olav M Kvalheim; Ina Schuppe-Koistinen; Sven P Jacobsson
Screening of biomarkers in rat urine using LC/electrospray ionization-MS and two-way data analysis.
Analytical chemistry 2003;75(18):4784-92.
2003: Bo Franzén; Kristina Duvefelt; Carina Jonsson; Britta Engelhardt; jan ottervald; Monica Wickman; Yang Yang; Ina Schuppe-Koistinen
Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-alpha.
Brain research. Molecular brain research 2003;115(2):130-46.
2002: Christina Lind; Robert Gerdes; Ylva Hamnell; Ina Schuppe-Koistinen; Helena Brockenhuus von Löwenhielm; Arne Holmgren; Ian A Cotgreave
Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis.
Archives of biochemistry and biophysics 2002;406(2):229-40.
2002: Ina Schuppe-Koistinen; Anna-Lena Frisk; Lars Janzon
Molecular profiling of hepatotoxicity induced by a aminoguanidine carboxylate in the rat: gene expression profiling.
Toxicology 2002;179(3):197-219.
2002: Heike Hellmold; Charlotte B Nilsson; Ina Schuppe-Koistinen; Kerstin Kenne; Lars Wärngård
Identification of end points relevant to detection of potentially adverse drug reactions.
Toxicology letters 2002;127(1-3):239-43.
2002: Ian A Cotgreave; Robert Gerdes; Ina Schuppe-Koistinen; Christina Lind
S-glutathionylation of glyceraldehyde-3-phosphate dehydrogenase: role of thiol oxidation and catalysis by glutaredoxin.
Methods in enzymology 2002;348():175-82.
1998: Christina Lind; Robert Gerdes; Ina Schuppe-Koistinen; Ian A Cotgreave
Studies on the mechanism of oxidative modification of human glyceraldehyde-3-phosphate dehydrogenase by glutathione: catalysis by glutaredoxin.
Biochemical and biophysical research communications 1998;247(2):481-6.