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Mike Schutkowski

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Protein Array Analysis

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Publications

TOP 3
Sébastien Moniot; Mike Schutkowski; Clemens Steegborn
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
Andreas Funkner; Natalya Gyrych; Hauke Lilie; Christoph Parthier; Mike Schutkowski; Milton T Stubbs; Johnny Zerweck; Gunter Fischer; David M Ferrari
Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.
Michele Tinti; Christopher T Workman; Nikolaj Blom; Søren Brunak; Martina Carducci; Luisa Castagnoli; Stefano Costa; Lars Kiemer; Francesca Langone; Kazuya Machida; Matthias Mann; Bruce J Mayer; Martin L Miller; Jesper V Olsen; Serena Paoluzi; Francesca Sacco; Mike Schutkowski; Christopher M Thompson; Gianni Cesareni
The SH2 Domain Interaction Landscape.

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All Publications

2013: Sébastien Moniot; Mike Schutkowski; Clemens Steegborn
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
Journal of structural biology 2013;182(2):136-43.
2013: Andreas Funkner; Natalya Gyrych; Hauke Lilie; Christoph Parthier; Mike Schutkowski; Milton T Stubbs; Johnny Zerweck; Gunter Fischer; David M Ferrari
Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.
Journal of molecular biology 2013;425(8):1340-62.
2013: Michele Tinti; Christopher T Workman; Nikolaj Blom; Søren Brunak; Martina Carducci; Luisa Castagnoli; Stefano Costa; Lars Kiemer; Francesca Langone; Kazuya Machida; Matthias Mann; Bruce J Mayer; Martin L Miller; Jesper V Olsen; Serena Paoluzi; Francesca Sacco; Mike Schutkowski; Christopher M Thompson; Gianni Cesareni
The SH2 Domain Interaction Landscape.
Cell reports 2013;3(4):1293-305.
2013: Annika Wolf; Markus Glaß; Stefan Hüttelmaier; Christian Ihling; Andrej Mun; Katrin Rietscher; Mike Schutkowski; Andrea Sinz; Aileen Wingenfeld; Mechthild Hatzfeld
Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
Journal of cell science 2013;126(Pt 8):1832-44.
2013: Mahadevan Lakshminarasimhan; David Rauth; Mike Schutkowski; Clemens Steegborn
Sirt1 activation by resveratrol is substrate sequence-selective.
Aging 2013;5(3):151-4.
2012: Karol H Wyszomirski; Mike Schutkowski; Jürgen Alves; Ute Curth; Detlev H Krüger; Petra Mackeldanz; Elisabeth Möncke-Buchner; Monika Reuter
Type III restriction endonuclease EcoP15I is a heterotrimeric complex containing one Res subunit with several DNA-binding regions and ATPase activity.
Nucleic acids research 2012;40(8):3610-22.
2012: Frank Fischer; Melanie Gertz; Mahadevan Lakshminarasimhan; Mike Schutkowski; Benjamin Suenkel; Clemens Steegborn
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
PloS one 2012;7(9):e45098.
2012: Martina Carducci; Luisa Castagnoli; Leonardo Briganti; Stefano Costa; Serena Paoluzi; Livia Perfetto; Mike Schutkowski; Johannes Zerweck; Gianni Cesareni
The protein interaction network mediated by human SH3 domains.
Biotechnology advances 2012;30(1):4-15.
2011: Alexandra Thiele; Gabriele I Stangl; Mike Schutkowski
Deciphering enzyme function using peptide arrays.
Molecular biotechnology 2011;49(3):283-305.
2011: Alexandra Thiele; Johannes Zerweck; Frank Erdmann; Gunter Fischer; Gerd Hause; Susann Kilka; Karolin Krentzlin; Stephanie Pösel; David Rauh; Mike Schutkowski; Matthias Weiwad
Parvulin 17 promotes microtubule assembly by its peptidyl-prolyl cis/trans isomerase activity.
Journal of molecular biology 2011;411(4):896-909.
2011: Silke Kuhfahl; Anja Hauburger; Tino Thieme; Jay Groppe; Christian Ihling; Sladjana Tomic; Mike Schutkowski; Andrea Sinz; Elisabeth Schwarz
Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.
Biochemical and biophysical research communications 2011;408(2):300-5.
2011: Chrisovalantis Papadopoulos; Krisztina Arato; Eva Lilienthal; Johannes Zerweck; Mike Schutkowski; Nicolas Chatain; Gerhard Müller-Newen; Walter Becker; Susana de la Luna
Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
The Journal of biological chemistry 2011;286(7):5494-505.
2010: Johannes A Hewel; Jian Liu; Kento Onishi; Vincent Fong; Shamanta Chandran; Jonathan B Olsen; Oxana Pogoutse; Mike Schutkowski; Holger Wenschuh; Dirk F H Winkler; Larry Eckler; Peter W Zandstra; Andrew Emili
Synthetic peptide arrays for pathway-level protein monitoring by liquid chromatography-tandem mass spectrometry.
Molecular & cellular proteomics : MCP 2010;9(11):2460-73.
2010: Alexandra Thiele; Matthias Weiwad; Johannes Zerweck; Gunter Fischer; Mike Schutkowski
High density peptide microarrays for proteome-wide fingerprinting of kinase activities in cell lysates.
Methods in molecular biology (Clifton, N.J.) 2010;669():173-81.
2010: Antonia Masch; Johannes Zerweck; Ulf Reimer; Holger Wenschuh; Mike Schutkowski
Antibody signatures defined by high-content peptide microarray analysis.
Methods in molecular biology (Clifton, N.J.) 2010;669():161-72.
2009: Simani Gaseitsiwe; Davide Valentini; Raija Ahmed; Shahnaz Mahdavifar; Isabelle Magalhaes; Johannes Zerweck; Mike Schutkowski; Emmanuel Gautherot; Felix Montero; Anneka Ehrnst; Marie Reilly; Markus J Maeurer
Major histocompatibility complex class II molecule-human immunodeficiency virus peptide analysis using a microarray chip.
Clinical and vaccine immunology : CVI 2009;16(4):567-73.
2009: Naomi Barak; Piotr Neumann; Madhumati Sevvana; Mike Schutkowski; Kai Naumann; Miroslav Malesević; Heike Reichardt; Gunter Fischer; Milton T Stubbs; David M Ferrari
Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29.
Journal of molecular biology 2009;385(5):1630-42.
2009: Alexandra Thiele; Johannes Zerweck; Matthias Weiwad; Gunter Fischer; Mike Schutkowski
High-density peptide microarrays for reliable identification of phosphorylation sites and upstream kinases.
Methods in molecular biology (Clifton, N.J.) 2009;570():203-19.
2009: Alexandra Thiele; Johannes Zerweck; Mike Schutkowski
Peptide arrays for enzyme profiling.
Methods in molecular biology (Clifton, N.J.) 2009;570():19-65.
2009: Ulrich Reineke; Mike Schutkowski
Epitope mapping protocols. Preface.
Methods in molecular biology (Clifton, N.J.) 2009;524():v-vi.
2009: Peter Lorenz; Michael Kreutzer; Johannes Zerweck; Mike Schutkowski; Hans-Jürgen Thiesen
Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease.
Methods in molecular biology (Clifton, N.J.) 2009;524():247-58.
2009: Johannes Zerweck; Antonia Masch; Mike Schutkowski
Peptide microarrays for profiling of modification state-specific antibodies.
Methods in molecular biology (Clifton, N.J.) 2009;524():169-80.
2008: Simani Gaseitsiwe; Davide Valentini; Shahnaz Mahdavifar; Isabelle Magalhaes; Daniel F Hoft; Johannes Zerweck; Mike Schutkowski; Jan Andersson; Marie Reilly; Markus J Maeurer
Pattern recognition in pulmonary tuberculosis defined by high content peptide microarray chip analysis representing 61 proteins from M. tuberculosis.
PloS one 2008;3(12):e3840.
2007: Tatjana Nahtman; Alexander Jernberg; Shahnaz Mahdavifar; Johannes Zerweck; Mike Schutkowski; Markus J Maeurer; Marie Reilly
Validation of peptide epitope microarray experiments and extraction of quality data.
Journal of immunological methods 2007;328(1-2):1-13.
2007: Victor Tapia; Juliane Bongartz; Mike Schutkowski; Nicole Bruni; Armin A Weiser; Bernhard Ay; Rudolf Volkmer; Michal Or-Guil
Affinity profiling using the peptide microarray technology: a case study.
Analytical biochemistry 2007;363(1):108-18.
2006: Dirk Wildemann; Frank Erdmann; Birte Hernandez Alvarez; Gerlind Stoller; Xiao Zhen Zhou; Jörg Fanghänel; Mike Schutkowski; Kun Ping Lu; Gunter Fischer
Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries.
Journal of medicinal chemistry 2006;49(7):2147-50.
2005: Mike Schutkowski; Ulrich Reineke; Ulf Reimer
Peptide arrays for kinase profiling.
Chembiochem : a European journal of chemical biology 2005;6(3):513-21.
2005: Chao Yu; Miroslav Malesevic; Günther Jahreis; Mike Schutkowski; Gunter Fischer; Cordelia Schiene-Fischer
The architecture of protein-ligand binding sites revealed through template-assisted intramolecular peptide-peptide interactions.
Angewandte Chemie (International ed. in English) 2005;44(9):1408-12.
2005: Yixin Zhang; Frank Erdmann; Ria Baumgrass; Mike Schutkowski; Gunter Fischer
Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression.
The Journal of biological chemistry 2005;280(6):4842-50.
2005: Angie S Mah; Andrew E H Elia; Geeta Devgan; Jason Ptacek; Mike Schutkowski; Michael Snyder; Michael B Yaffe; Raymond J Deshaies
Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening.
BMC biochemistry 2005;6():22.
2004: Yixin Zhang; Ria Baumgrass; Ria Raumgrass; Mike Schutkowski; Gunter Fischer
Branches on the alpha-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding.
Chembiochem : a European journal of chemical biology 2004;5(7):1006-9.
2004: Mike Schutkowski; Ulf Reimer; Sören Panse; Liying Dong; Jose Lizcano; Dario R Alessi; Jens Schneider-Mergener
High-content peptide microarrays for deciphering kinase specificity and biology.
Angewandte Chemie (International ed. in English) 2004;43(20):2671-4.
2004: Leszek Rychlewski; Maik Kschischo; Liying Dong; Mike Schutkowski; Ulf Reimer
Target specificity analysis of the Abl kinase using peptide microarray data.
Journal of molecular biology 2004;336(2):307-11.
2004: Sören Panse; Liying Dong; Antje Burian; Robert Carus; Mike Schutkowski; Ulf Reimer; Jens Schneider-Mergener
Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and fluorescence-based assays.
Molecular diversity 2004;8(3):291-9.
2003: Jérôme Boudeau; Annette F Baas; Maria Deak; Nick A Morrice; Agnieszka Kieloch; Mike Schutkowski; Alan R Prescott; Hans Clevers; Dario R Alessi
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
The EMBO journal 2003;22(19):5102-14.
2002: Yixin Zhang; Susanne Füssel; Ulf Reimer; Mike Schutkowski; Gunter Fischer
Substrate-based design of reversible Pin1 inhibitors.
Biochemistry 2002;41(39):11868-77.
2002: Jose Lizcano; Maria Deak; Nick Morrice; Agnieszka Kieloch; C James Hastie; Liying Dong; Mike Schutkowski; Ulf Reimer; Dario R Alessi
Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
The Journal of biological chemistry 2002;277(31):27839-49.
2000: Matthias Weiwad; Gerd Küllertz; Mike Schutkowski; Gunter Fischer
Evidence that the substrate backbone conformation is critical to phosphorylation by p42 MAP kinase.
FEBS letters 2000;478(1-2):39-42.
1999: Oliver Bieri; Jakob Wirz; Bruno Hellrung; Mike Schutkowski; Mario Drewello; Thomas Kiefhaber
The speed limit for protein folding measured by triplet-triplet energy transfer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9597-601.
1998: C Schiene; Ulf Reimer; Mike Schutkowski; Gunter Fischer
Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases.
FEBS letters 1998;432(3):202-6.
1998: Ulf Reimer; G Scherer; Mario Drewello; S Kruber; Mike Schutkowski; Gunter Fischer
Side-chain effects on peptidyl-prolyl cis/trans isomerisation.
Journal of molecular biology 1998;279(2):449-60.
1998: Mike Schutkowski; A Bernhardt; Xiao Zhen Zhou; M Shen; Ulf Reimer; JU Rahfeld; Kun Ping Lu; Gunter Fischer
Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition.
Biochemistry 1998;37(16):5566-75.
1998: Matthias Brandsch; Frank Thunecke; Gerd Küllertz; Mike Schutkowski; Gunter Fischer; Klaus Neubert
Evidence for the absolute conformational specificity of the intestinal H+/peptide symporter, PEPT1.
The Journal of biological chemistry 1998;273(7):3861-4.
1997: Michael B Yaffe; Mike Schutkowski; M Shen; Xiao Zhen Zhou; P Todd Stukenberg; JU Rahfeld; J Xu; Jian Kuang; Marc W Kirschner; Gunter Fischer; Lewis C Cantley; Kun Ping Lu
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.
Science (New York, N.Y.) 1997;278(5345):1957-60.
1997: Ulf Reimer; N el Mokdad; Mike Schutkowski; Gunter Fischer
Intramolecular assistance of cis/trans isomerization of the histidine-proline moiety.
Biochemistry 1997;36(45):13802-8.
1997: B Janowski; S Wöllner; Mike Schutkowski; Gunter Fischer
A protease-free assay for peptidyl prolyl cis/trans isomerases using standard peptide substrates.
Analytical biochemistry 1997;252(2):299-307.
1997: Ulf Reimer; Mario Drewello; M Jakob; Gunter Fischer; Mike Schutkowski
Conformational state of a 25-mer peptide from the cyclophilin-binding loop of the HIV type 1 capsid protein.
The Biochemical journal 1997;326 ( Pt 1)():181-5.
1997: A Bernhardt; Mario Drewello; Mike Schutkowski
The solid-phase synthesis of side-chain-phosphorylated peptide-4-nitroanilides.
The journal of peptide research : official journal of the American Peptide Society 1997;50(2):143-52.
1997: Mike Schutkowski; M Jakob; G Landgraf; Ilona Born; Klaus Neubert; G Fischer
Probing substrate backbone function in prolyl oligopeptidase catalysis--large positional effects of peptide bond monothioxylation.
European journal of biochemistry / FEBS 1997;245(2):381-5.
1996: A Kaspari; Angelika Schierhorn; Mike Schutkowski
Solid-phase synthesis of peptide-4-nitroanilides.
International journal of peptide and protein research 1996;48(5):486-94.
1996: Mike Schutkowski; Mario Drewello; S Wöllner; M Jakob; Ulf Reimer; G Scherer; Angelika Schierhorn; Gunter Fischer
Extended binding sites of cyclophilin as revealed by the interaction with HIV-1 Gag polyprotein derived oligopeptides.
FEBS letters 1996;394(3):289-94.
1995: Wolfgang Brandt; T Lehmann; I Thondorf; I Born; Mike Schutkowski; Jens-Ulrich Rahfeld; Klaus Neubert; A Barth
A model of the active site of dipeptidyl peptidase IV predicted by comparative molecular field analysis and molecular modelling simulations.
International journal of peptide and protein research 1995;46(6):494-507.
1995: Mike Schutkowski; S Wöllner; Gunter Fischer
Inhibition of peptidyl-prolyl cis/trans isomerase activity by substrate analog structures: thioxo tetrapeptide-4-nitroanilides.
Biochemistry 1995;34(40):13016-26.
1995: Mike Schutkowski; Carmen Mrestani-Klaus; Klaus Neubert
Synthesis of dipeptide 4-nitroanilides containing non-proteinogenic amino acids.
International journal of peptide and protein research 1995;45(3):257-65.
1994: Mike Schutkowski; Klaus Neubert; G Fischer
Influence on proline-specific enzymes of a substrate containing the thioxoaminoacyl-prolyl peptide bond.
European journal of biochemistry / FEBS 1994;221(1):455-61.
1991: Jens-Ulrich Rahfeld; Mike Schutkowski; J Faust; Klaus Neubert; A Barth; J Heins
Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney.
Biological chemistry Hoppe-Seyler 1991;372(5):313-8.