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John Schutzbach

Research Profile

Chemicals & Drugs

Concepts & Ideas

Anatomy

Microsomes, Liver

Living Beings

Physiology

Enzyme Activation

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

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Yin Gao; Bin Liu; John S Schutzbach; Scott Strum; Walter A Szarek; Vladimir I Torgov; Natalia S Utkina; Vladimir V Veselovsky; Jason Z Vlahakis; Lei Wang; Leonid L Danilov; TN Druzhinina; Inka Brockhausen
Biochemical characterization of WbdN, a β1,3-glucosyltransferase involved in O-antigen synthesis in enterohemorrhagic Escherichia coli O157.
John S Schutzbach; Inka Brockhausen
Inhibition of glycosyltransferase activities as the basis for drug development.
John S Schutzbach; Helmut Ankel; Inka Brockhausen
Synthesis of cell envelope glycoproteins of Cryptococcus laurentii.

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All Publications

2012: Yin Gao; Bin Liu; John S Schutzbach; Scott Strum; Walter A Szarek; Vladimir I Torgov; Natalia S Utkina; Vladimir V Veselovsky; Jason Z Vlahakis; Lei Wang; Leonid L Danilov; TN Druzhinina; Inka Brockhausen
Biochemical characterization of WbdN, a β1,3-glucosyltransferase involved in O-antigen synthesis in enterohemorrhagic Escherichia coli O157.
Glycobiology 2012;22(8):1092-102.
2009: John S Schutzbach; Inka Brockhausen
Inhibition of glycosyltransferase activities as the basis for drug development.
Methods in molecular biology (Clifton, N.J.) 2009;534():359-73.
2007: John S Schutzbach; Helmut Ankel; Inka Brockhausen
Synthesis of cell envelope glycoproteins of Cryptococcus laurentii.
Carbohydrate research 2007;342(7):881-93.
2006: Inka Brockhausen; Melinda Benn; Shridhar Bhat; Sandra Marone; John G Riley; Pedro J Montoya-Peleaz; Jason Z Vlahakis; Hans Paulsen; John S Schutzbach; Walter A Szarek
UDP-Gal: GlcNAc-R beta1,4-galactosyltransferase--a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme.
Glycoconjugate journal 2006;23(7-8):525-41.
2006: Ejvis Lamani; R Brandon Mewbourne; Damona S Fletcher; Sergei D Maltsev; Leonid L Danilov; Vladimir V Veselovsky; Antonina V Lozanova; Natalia Ya Grigorieva; Olga A Pinsker; Jun Xing; W Thomas Forsee; Herbert C Cheung; John S Schutzbach; Vladimir N Shibaev; Mark J Jedrzejas
Structural studies and mechanism of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase: insights into the initial step of synthesis of dolichyl-phosphate-linked oligosaccharide chains in membranes of endoplasmic reticulum.
Glycobiology 2006;16(7):666-78.
2006: John S Schutzbach
Assay of dolichyl-phospho-mannose synthase reconstituted in a lipid matrix.
Methods in molecular biology (Clifton, N.J.) 2006;347():31-41.
2005: John G Riley; Mohammed Menggad; Pedro J Montoya-Peleaz; Walter A Szarek; Cristina L Marolda; Miguel A Valvano; John S Schutzbach; Inka Brockhausen
The wbbD gene of E. coli strain VW187 (O7:K1) encodes a UDP-Gal: GlcNAc{alpha}-pyrophosphate-R {beta}1,3-galactosyltransferase involved in the biosynthesis of O7-specific lipopolysaccharide.
Glycobiology 2005;15(6):605-13.
2005: Pedro J Montoya-Peleaz; John G Riley; Walter A Szarek; Miguel A Valvano; John S Schutzbach; Inka Brockhausen
Identification of a UDP-Gal: GlcNAc-R galactosyltransferase activity in Escherichia coli VW187.
Bioorganic & medicinal chemistry letters 2005;15(4):1205-11.
2005: Dipak K Banerjee; Elena A Carrasquillo; Patsy Hughey; John S Schutzbach; Juan A Martínez; Krishna Baksi
In vitro phosphorylation by cAMP-dependent protein kinase up-regulates recombinant Saccharomyces cerevisiae mannosylphosphodolichol synthase.
The Journal of biological chemistry 2005;280(6):4174-81.
2003: Xiaojing Yang; Wensheng Qin; Michael Lehotay; Dale Toki; Philip Dennis; John S Schutzbach; Inka Brockhausen
Soluble human core 2 beta6-N-acetylglucosaminyltransferase C2GnT1 requires its conserved cysteine residues for full activity.
Biochimica et biophysica acta 2003;1648(1-2):62-74.
2000: Jun Xing; W Thomas Forsee; Ejvis Lamani; Sergei D Maltsev; Leonid L Danilov; Vladimir N Shibaev; John S Schutzbach; Herbert C Cheung; Mark J Jedrzejas
Investigations of the active site of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase using fluorescent labeled dolichyl-phosphate derivatives.
Biochemistry 2000;39(27):7886-94.
2000: Robert T Cartee; W Thomas Forsee; John S Schutzbach; Janet Yother
Mechanism of type 3 capsular polysaccharide synthesis in Streptococcus pneumoniae.
The Journal of biological chemistry 2000;275(6):3907-14.
1998: Inka Brockhausen; John S Schutzbach; W Kuhns
Glycoproteins and their relationship to human disease.
Acta anatomica 1998;161(1-4):36-78.
1997: W Thomas Forsee; D McPherson; John S Schutzbach
Characterization of recombinant yeast dolichyl mannosyl phosphate synthase and site-directed mutagenesis of its cysteine residues.
European journal of biochemistry / FEBS 1997;244(3):953-8.
1997: John S Schutzbach
The role of the lipid matrix in the biosynthesis of dolichyl-linked oligosaccharides.
Glycoconjugate journal 1997;14(2):175-82.
1994: A Lal; John S Schutzbach; W T Forsee; peter neame; Kelley W Moremen
Isolation and expression of murine and rabbit cDNAs encoding an alpha 1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides.
The Journal of biological chemistry 1994;269(13):9872-81.
1994: Helene Bernstein; S P Tucker; Eric Hunter; John S Schutzbach; Richard W Compans
Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides.
Journal of virology 1994;68(1):463-8.
1994: John S Schutzbach
Is there a "dolichol recognition sequence" in enzymes that interact with dolichols and other polyisoprenoid substrates?
Acta biochimica Polonica 1994;41(3):269-74.
1993: John S Schutzbach; J W Zimmerman; W T Forsee
The purification and characterization of recombinant yeast dolichyl-phosphate-mannose synthase. Site-directed mutagenesis of the putative dolichol recognition sequence.
The Journal of biological chemistry 1993;268(32):24190-6.
1992: John S Schutzbach; J W Zimmerman
Yeast dolichyl-phosphomannose synthase: reconstitution of enzyme activity with phospholipids.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(6):460-5.
1990: John S Schutzbach; W T Forsee
Calcium ion activation of rabbit liver alpha 1,2-mannosidase.
The Journal of biological chemistry 1990;265(5):2546-9.
1989: John S Schutzbach; J W Jensen
Bilayer membrane destabilization induced by dolichylphosphate.
Chemistry and physics of lipids 1989;51(3-4):213-8.
1989: W T Forsee; C F Palmer; John S Schutzbach
Purification and characterization of an alpha-1,2-mannosidase involved in processing asparagine-linked oligosaccharides.
The Journal of biological chemistry 1989;264(7):3869-76.
1989: J W Jensen; John S Schutzbach
Phospholipase-induced modulation of dolichyl-phosphomannose synthase activity.
Biochemistry 1989;28(2):851-5.
1988: J W Jensen; John S Schutzbach
Modulation of dolichyl-phosphomannose synthase activity by changes in the lipid environment of the enzyme.
Biochemistry 1988;27(17):6315-20.
1987: John S Schutzbach
A fluorescence assay for alpha-1,2-mannosidases involved in glycoprotein processing reactions.
Analytical biochemistry 1987;167(2):279-83.
1987: J A Monti; S T Christian; John S Schutzbach
Effects of dolichol on membrane permeability.
Biochimica et biophysica acta 1987;905(1):133-42.
1986: J W Jensen; John S Schutzbach
Characterization of mannosyl-transfer reactions catalyzed by dolichyl-mannosyl-phosphate-synthase.
Carbohydrate research 1986;149(1):199-208.
1985: J W Jensen; John S Schutzbach
Activation of dolichyl-phospho-mannose synthase by phospholipids.
European journal of biochemistry / FEBS 1985;153(1):41-8.
1983: W T Forsee; John S Schutzbach
Interaction of alpha-1,2-mannosidase with anionic phospholipids.
European journal of biochemistry / FEBS 1983;136(3):577-82.
1982: W T Forsee; J D Springfield; John S Schutzbach
Effect of phospholipids on alpha-1,2-mannosidase activity.
The Journal of biological chemistry 1982;257(17):9963-7.
1982: J W Jensen; John S Schutzbach
The biosynthesis of oligosaccharide-lipids. Activation of mannosyltransferase II by specific phospholipids.
The Journal of biological chemistry 1982;257(15):9025-9.
1981: J W Jensen; John S Schutzbach
The biosynthesis of oligosaccharide-lipids. Partial purification and characterization of mannosyltransferase II.
The Journal of biological chemistry 1981;256(24):12899-904.
1981: W T Forsee; John S Schutzbach
Purification and characterization of a phospholipid-dependent alpha-mannosidase from rabbit liver.
The Journal of biological chemistry 1981;256(13):6577-82.
1980: J W Jensen; J D Springfield; John S Schutzbach
The biosynthesis of oligosaccharide-lipids. Isolation of an oligosaccharide-P-P-lipid acceptor.
The Journal of biological chemistry 1980;255(23):11268-72.
1980: John S Schutzbach; J D Springfield; J W Jensen
The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage.
The Journal of biological chemistry 1980;255(9):4170-5.