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Rainer Schwaab

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Laurynas Daugela; Nicole Nüsgen; Johannes Oldenburg; Rainer Schwaab; Maja Walier; Osman El-Maarri
Measurements of DNA methylation at seven loci in various tissues of CD1 mice.
Osman El-Maarri; Maja Walier; Frank Behne; Jan van Üüm; Heike Singer; Amalia Diaz-Lacava; Nicole Nüsgen; Barbara Niemann; Matthias Watzka; Jochen Reinsberg; Hans van der Ven; Thomas F Wienker; Birgit Stoffel-Wagner; Rainer Schwaab; Johannes Oldenburg
Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles.
M A Srour; J Grupp; Z Aburubaiha; Thilo Albert; H Brondke; Johannes Oldenburg; Rainer Schwaab
Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein.

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2012: Laurynas Daugela; Nicole Nüsgen; Johannes Oldenburg; Rainer Schwaab; Maja Walier; Osman El-Maarri
Measurements of DNA methylation at seven loci in various tissues of CD1 mice.
PloS one 2012;7(9):e44585.
2011: Osman El-Maarri; Maja Walier; Frank Behne; Jan van Üüm; Heike Singer; Amalia Diaz-Lacava; Nicole Nüsgen; Barbara Niemann; Matthias Watzka; Jochen Reinsberg; Hans van der Ven; Thomas F Wienker; Birgit Stoffel-Wagner; Rainer Schwaab; Johannes Oldenburg
Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles.
PloS one 2011;6(1):e16252.
2008: M A Srour; J Grupp; Z Aburubaiha; Thilo Albert; H Brondke; Johannes Oldenburg; Rainer Schwaab
Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein.
Annals of hematology 2008;87(2):107-12.
2007: Osman El-Maarri; Tim Becker; Judith Junen; Syed Saadi Manzoor; Amalia Diaz-Lacava; Rainer Schwaab; Thomas F Wienker; Johannes Oldenburg
Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males.
Human genetics 2007;122(5):505-14.
2006: J Schröder; Osman El-Maarri; Rainer Schwaab; Clemens R Müller; J Oldenburg
Factor VIII intron-1 inversion: frequency and inhibitor prevalence.
Journal of thrombosis and haemostasis : JTH 2006;4(5):1141-3.
2006: Osman El-Maarri; Heike Singer; Claudia Klein; Matthias Watzka; Ursula Herbiniaux; Hans H Brackmann; Jörg Schröder; Jochen Graw; Clemens R Müller; Wolfgang Schramm; Rainer Schwaab; Thomas Haaf; Peter Hanfland; Johannes Oldenburg
Lack of F8 mRNA: a novel mechanism leading to hemophilia A.
Blood 2006;107(7):2759-65.
2005: Jochen Graw; Hans H Brackmann; Johannes Oldenburg; Reinhard Schneppenheim; Michael Spannagl; Rainer Schwaab
Haemophilia A: from mutation analysis to new therapies.
Nature reviews. Genetics 2005;6(6):488-501.
2005: Osman El-Maarri; Ursula Herbiniaux; Jochen Graw; J Schröder; A Terzic; Matthias Watzka; Hans H Brackmann; W Schramm; Peter Hanfland; Rainer Schwaab; Clemens R Müller; Johannes Oldenburg
Analysis of mRNA in hemophilia A patients with undetectable mutations reveals normal splicing in the factor VIII gene.
Journal of thrombosis and haemostasis : JTH 2005;3(2):332-9.
2004: Johannes Oldenburg; Jörg Schröder; Hans H Brackmann; Clemens Müller-Reible; Rainer Schwaab; Edward G D Tuddenham
Environmental and genetic factors influencing inhibitor development.
Seminars in hematology 2004;41(1 Suppl 1):82-8.
2003: Mahmoud A Srour; Henry Fechner; Xiaomin Wang; Ulrike Siemetzki; Thilo Albert; Johannes Oldenburg; Peter Hanfland; Wolfgang Poller; Hans H Brackmann; Rainer Schwaab
Regulation of human factor IX expression using doxycycline-inducible gene expression system.
Thrombosis and haemostasis 2003;90(3):398-405.
2003: Henry Fechner; Xiaomin Wang; M Srour; Ulrike Siemetzki; Holger Seltmann; Andreas P Sutter; Hans Scherübl; Christos Zouboulis; Rainer Schwaab; Wolfgang Hillen; Heinz-Peter Schultheiss; Wolfgang Poller
A novel tetracycline-controlled transactivator-transrepressor system enables external control of oncolytic adenovirus replication.
Gene therapy 2003;10(19):1680-90.
2003: Hans H Brackmann; Thilo Albert; Jochen Graw; Johannes Oldenburg; W Schramm; Rainer Schwaab
[Gathering and evaluation of phenotype data of haemophilia A patients for correlation with genotype data].
Hämostaseologie 2003;23(1):24-7.
2003: H Krebs; C Domsch; K Adelhard; Hans H Brackmann; Jochen Graw; J Oldenburg; Rainer Schwaab; W Schramm
[The national GTH haemophilia registry as database within the scope of the German human genome project].
Hämostaseologie 2003;23(1):18-23.
2003: Thilo Albert; S Lange; Johannes Oldenburg; Jochen Graw; W Schramm; Peter Hanfland; Hans H Brackmann; Rainer Schwaab
[Characterization of factor VIII antibody epitopes from haemophilia A patients using cellulose bound FVIII peptide libraries].
Hämostaseologie 2003;23(1):13-7.
2003: Johannes Oldenburg; J Schröder; Jochen Graw; Vytautas Ivaskevicius; Hans H Brackmann; W Schramm; Clemens R Müller; Erhard Seifried; Rainer Schwaab
[Significance of mutation analysis in patients with haemophilia A].
Hämostaseologie 2003;23(1):6-12.
2003: C Uen; J Oldenburg; J Schröder; H-J Brackmann; W Schramm; Rainer Schwaab; R Schneppenheim; Jochen Graw
[2% Haemophilia A patients without mutation in the FVIII gene].
Hämostaseologie 2003;23(1):1-5.
2002: Hans H Brackmann; Wolfgang Effenberger; Rainer Schwaab; Lothar Hess; Peter Hanfland; Johannes Oldenburg
Quality management and quality assurance in haemophilia care: a model at the Bonn haemophilia centre.
Haemophilia : the official journal of the World Federation of Hemophilia 2002;8(3):211-6.
2002: Johannes Oldenburg; Osman El-Maarri; Rainer Schwaab
Inhibitor development in correlation to factor VIII genotypes.
Haemophilia : the official journal of the World Federation of Hemophilia 2002;8 Suppl 2():23-9.
2001: Rainer Schwaab; Johannes Oldenburg
Gene therapy of hemophilia.
Seminars in thrombosis and hemostasis 2001;27(4):417-24.
2001: Johannes Oldenburg; Rainer Schwaab
Molecular biology of blood coagulation.
Seminars in thrombosis and hemostasis 2001;27(4):313-24.
2001: Vytautas Ivaskevicius; R Jurgutis; Simone Rost; A Müller; C Schmitt; Karin Wulff; Falko H Herrmann; Clemens R Müller; Rainer Schwaab; Johannes Oldenburg
Lithuanian haemophilia A and B registry comprising phenotypic and genotypic data.
British journal of haematology 2001;112(4):1062-70.
2000: Johannes Oldenburg; B von Brederlow; Andreas Fregin; Simone Rost; Werner Wolz; W Eberl; Stefan W Eber; E Lenz; Rainer Schwaab; Hans H Brackmann; Wolfgang Effenberger; Ursula Harbrecht; Leon J Schurgers; Cees Vermeer; Clemens R Müller
Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex.
Thrombosis and haemostasis 2000;84(6):937-41.
2000: Johannes Oldenburg; Simone Rost; Osman El-Maarri; Marco Leuer; K Olek; Clemens R Müller; Rainer Schwaab
De novo factor VIII gene intron 22 inversion in a female carrier presents as a somatic mosaicism.
Blood 2000;96(8):2905-6.
2000: Hans H Brackmann; Rainer Schwaab; Wolfgang Effenberger; Lothar Hess; Peter Hanfland; Johannes Oldenburg
Hemophilia treatment. Side effects during immune tolerance induction.
Haematologica 2000;85(10 Suppl):75-7.
2000: Johannes Oldenburg; Hans H Brackmann; Rainer Schwaab
Risk factors for inhibitor development in hemophilia A.
Haematologica 2000;85(10 Suppl):7-13; discussion 13-4.
2000: D Happich; Katharina Madlener; Rainer Schwaab; Peter Hanfland; Bernd Pötzsch
Application of the TaqMan-PCR for genotyping of the prothrombin G20210A mutation and of the thermolabile methylenetetrahydrofolate reductase mutation.
Thrombosis and haemostasis 2000;84(1):144-5.
2000: Rainer Schwaab; Johannes Oldenburg; G Kemball-Cook; Thilo Albert; C Juhler; Peter Hanfland; Jørgen Ingerslev
Assay discrepancy in mild haemophilia A due to a factor VIII missense mutation (Asn694Ile) in a large Danish family.
British journal of haematology 2000;109(3):523-8.
2000: Hans H Brackmann; E Effenberger; Lothar Hess; Rainer Schwaab; Johannes Oldenburg
NovoSeven in immune tolerance therapy.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2000;11 Suppl 1():S39-44.
2000: Hans H Brackmann; Rainer Schwaab; Wolfgang Effenberger; Lothar Hess; Peter Hanfland; Johannes Oldenburg
Antibodies to factor VIII in hemophilia A patients.
Vox sanguinis 2000;78 Suppl 2():187-90.
2000: Johannes Oldenburg; Hans H Brackmann; Peter Hanfland; Rainer Schwaab
Molecular genetics in haemophilia A.
Vox sanguinis 2000;78 Suppl 2():33-8.
1999: D Happich; Rainer Schwaab; Peter Hanfland; D Hoernschemeyer
Allelic discrimination of factor V Leiden using a 5' nuclease assay.
Thrombosis and haemostasis 1999;82(4):1294-6.
1999: A Haack; Wolfgang Poller; S Schneider-Rasp; P Thalheimer; C Schmitt; Peter Hanfland; Hans H Brackmann; Rainer Schwaab
Highly sensitive and species-specific assay for quantification of human transgene expression levels.
Haemophilia : the official journal of the World Federation of Hemophilia 1999;5(5):334-9.
1999: A Haack; C Schmitt; Wolfgang Poller; Johannes Oldenburg; Peter Hanfland; Hans H Brackmann; Rainer Schwaab
Analysis of expression kinetics and activity of a new B-domain truncated and full-length FVIII protein in three different cell lines.
Annals of hematology 1999;78(3):111-6.
1999: Johannes Oldenburg; Rainer Schwaab; Hans H Brackmann
Induction of immune tolerance in haemophilia A inhibitor patients by the 'Bonn Protocol': predictive parameter for therapy duration and outcome.
Vox sanguinis 1999;77 Suppl 1():49-54.
1998: Birgit Stoffel-Wagner; Matthias Watzka; Stephan Steckelbroeck; Rainer Schwaab; Johannes Schramm; Frank Bidlingmaier; Dietrich Klingmüller
Expression of CYP19 (aromatase) mRNA in the human temporal lobe.
Biochemical and biophysical research communications 1998;244(3):768-71.
1998: Johannes Oldenburg; J Schröder; C Schmitt; H H Brackmann; Rainer Schwaab
Small deletion/insertion mutations within poly-A runs of the factor VIII gene mitigate the severe haemophilia A phenotype.
Thrombosis and haemostasis 1998;79(2):452-3.
1998: Hans H Brackmann; Wolfgang Effenberger; Lothar Hess; Rainer Schwaab; Johannes Oldenburg
Immune tolerance induction: a role for recombinant activated factor VII (rFVIIa)?
European journal of haematology. Supplementum 1998;63():18-23.
1998: I Scharrer; O Neutzling; Rainer Schwaab; Johannes Oldenburg; H Ehrlich
Experiences with recombinant factor VIII products: development of inhibitors and immune tolerance therapy.
Annals of hematology 1998;76 Suppl 1():A1-6.
1997: Rainer Schwaab; Johannes Oldenburg; M R Lalloz; Ulrike Schwaab; S Pemberton; Peter Hanfland; Hans H Brackmann; Edward G D Tuddenham; Katerina Michaelides
Factor VIII gene mutations found by a comparative study of SSCP, DGGE and CMC and their analysis on a molecular model of factor VIII protein.
Human genetics 1997;101(3):323-32.
1997: Johannes Oldenburg; E M Quenzel; Ursula Harbrecht; Andreas Fregin; Wolfram Kress; Clemens R Müller; Hans-Joerg Hertfelder; Rainer Schwaab; Hans H Brackmann; Peter Hanfland
Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy.
British journal of haematology 1997;98(1):240-4.
1997: Johannes Oldenburg; J K Picard; Rainer Schwaab; Hans H Brackmann; Edward G D Tuddenham; E Simpson
HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII.
Thrombosis and haemostasis 1997;77(2):238-42.
1997: Johannes Oldenburg; Tiemo Grimm; J Becker; K Olek; Hans H Brackmann; Rainer Schwaab
Mutations in severe hemophilia A: distribution within the factor VIII gene, origin and influence on inhibitor development.
Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine 1997;34():224-30.
1996: Reinhard Schneppenheim; Ulrich Budde; S Krey; E Drewke; F Bergmann; E Lechler; Johannes Oldenburg; Rainer Schwaab
Results of a screening for von Willebrand disease type 2N in patients with suspected haemophilia A or von Willebrand disease type 1.
Thrombosis and haemostasis 1996;76(4):598-602.
1996: William C Nichols; K Amano; P M Cacheris; M S Figueiredo; K Michaelides; Rainer Schwaab; L Hoyer; Randal J Kaufman; David Ginsburg
Moderation of hemophilia A phenotype by the factor V R506Q mutation.
Blood 1996;88(4):1183-7.
1996: Wolfgang Poller; S Schneider-Rasp; U Liebert; F Merklein; P Thalheimer; A Haack; Rainer Schwaab; C Schmitt; Hans H Brackmann
Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host.
Gene therapy 1996;3(6):521-30.
1996: J Becker; Rainer Schwaab; A Möller-Taube; U Schwaab; W Schmidt; Hans H Brackmann; Tiemo Grimm; K Olek; Johannes Oldenburg
Characterization of the factor VIII defect in 147 patients with sporadic hemophilia A: family studies indicate a mutation type-dependent sex ratio of mutation frequencies.
American journal of human genetics 1996;58(4):657-70.
1996: Hans H Brackmann; Johannes Oldenburg; Rainer Schwaab
Immune tolerance for the treatment of factor VIII inhibitors--twenty years' 'bonn protocol'.
Vox sanguinis 1996;70 Suppl 1():30-5.
1996: Francesco Giannelli; Peter M Green; S S Sommer; M C Poon; M Ludwig; Rainer Schwaab; P H Reitsma; M Goossens; A Yoshioka; George G Brownlee
Haemophilia B (sixth edition): a database of point mutations and short additions and deletions.
Nucleic acids research 1996;24(1):103-18.
1995: Rainer Schwaab; Hans H Brackmann; C Meyer; J Seehafer; M Kirchgesser; A Haack; K Olek; Edward G D Tuddenham; Johannes Oldenburg
Haemophilia A: mutation type determines risk of inhibitor formation.
Thrombosis and haemostasis 1995;74(6):1402-6.
1995: Rainer Schwaab; Johannes Oldenburg; U Schwaab; D J Johnson; W Schmidt; K Olek; H H Brackman; Edward G D Tuddenham
Characterization of mutations within the factor VIII gene of 73 unrelated mild and moderate haemophiliacs.
British journal of haematology 1995;91(2):458-64.
1994: J P Faber; Wolfgang Poller; S Weidinger; M Kirchgesser; Rainer Schwaab; F Bidlingmaier; K Olek
Identification and DNA sequence analysis of 15 new alpha 1-antitrypsin variants, including two PI*Q0 alleles and one deficient PI*M allele.
American journal of human genetics 1994;55(6):1113-21.
1994: Edward G D Tuddenham; Rainer Schwaab; J Seehafer; D S Millar; Jane Gitschier; M Higuchi; S Bidichandani; J M Connor; L W Hoyer; A Yoshioka
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.
Nucleic acids research 1994;22(22):4851-68.
1994: G Mertes; M Ludwig; B Finkelnburg; M Krawczak; Rainer Schwaab; Hans H Brackmann; K Olek
A G+3-to-T donor splice site mutation leads to skipping of exon 50 in von Willebrand factor mRNA.
Genomics 1994;24(1):190-1.
1994: Francesco Giannelli; Peter M Green; S S Sommer; D P Lillicrap; M Ludwig; Rainer Schwaab; P H Reitsma; M Goossens; A Yoshioka; George G Brownlee
Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994.
Nucleic acids research 1994;22(17):3534-46.
1994: Edward G D Tuddenham; Rainer Schwaab; J Seehafer; D S Millar; Jane Gitschier; M Higuchi; S Bidichandani; J M Connor; L W Hoyer; A Yoshioka
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.
Nucleic acids research 1994;22(17):3511-33.
1994: L Kochhan; M R Lalloz; Johannes Oldenburg; John H McVey; K Olek; Hans H Brackmann; Edward G D Tuddenham; Rainer Schwaab
Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(4):497-501.
1994: D David; I Moreira; M R Lalloz; H A Rosa; Rainer Schwaab; S Morais; M J Diniz; G de Deus; M Campos; João Lavinha
Analysis of the essential sequences of the factor VIII gene in twelve haemophilia A patients by single-stranded conformation polymorphism.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(2):257-64.
1994: M R Lalloz; Rainer Schwaab; John H McVey; K Michaelides; Edward G D Tuddenham
Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene.
British journal of haematology 1994;86(4):804-9.
1994: Rainer Schwaab; Johannes Oldenburg; Hans H Brackmann; Peter Hanfland
[Hemophilia A: molecular biology and carrier diagnosis].
Infusionstherapie und Transfusionsmedizin 1994;21(2):116-25.
1993: G Mertes; M Ludwig; Rainer Schwaab; H H Brackmann; K Olek
Delta C in exon 18 of the von Willebrand gene is uncommon in German vWD type III patients.
Thrombosis and haemostasis 1993;70(6):1064-5.
1993: Johannes Oldenburg; Rainer Schwaab; Tiemo Grimm; Klaus Zerres; P Hakenberg; Hans H Brackmann; K Olek
Direct and indirect estimation of the sex ratio of mutation frequencies in hemophilia A.
American journal of human genetics 1993;53(6):1229-38.
1993: Francesco Giannelli; Peter M Green; Katherine A High; S Sommer; M C Poon; M Ludwig; Rainer Schwaab; P H Reitsma; M Goossens; A Yoshioka
Haemophilia B: database of point mutations and short additions and deletions--fourth edition, 1993.
Nucleic acids research 1993;21(13):3075-87.
1993: Hans H Brackmann; E Aygören; I Scharrer; Rainer Schwaab; U Hammerstein; Johannes Oldenburg
Two years' experience with two recombinant factor VIII concentrates.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(3):421-4.
1993: Rainer Schwaab; Johannes Oldenburg; E G Tuddenham; Hans H Brackmann; K Olek
Mutations in haemophilia A.
British journal of haematology 1993;83(3):450-8.
1991: Edward G D Tuddenham; David N Cooper; Jane Gitschier; M Higuchi; L W Hoyer; A Yoshioka; I R Peake; Rainer Schwaab; K Olek; Haig Kazazian
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene.
Nucleic acids research 1991;19(18):4821-33.
1991: Rainer Schwaab; M Ludwig; L Kochhan; Johannes Oldenburg; John H McVey; H Egli; Hans H Brackmann; K Olek
Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain.
Thrombosis research 1991;61(3):225-34.
1990: Rainer Schwaab; M Ludwig; Johannes Oldenburg; Hans H Brackmann; H Egli; L Kochhan; K Olek
Identical point mutations in the factor VIII gene that have different clinical manifestations of hemophilia A.
American journal of human genetics 1990;47(4):743-4.
1989: M Higuchi; L Kochhan; Rainer Schwaab; H Egli; Hans H Brackmann; Jürgen Horst; K Olek
Molecular defects in hemophilia A: identification and characterization of mutations in the factor VIII gene and family analysis.
Blood 1989;74(3):1045-51.
1989: B Ewerhardt; M Ludwig; Rainer Schwaab; Reinhard Schneppenheim; K Olek
An EcoRI polymorphism in the human von Willebrand factor (vWF) gene.
Nucleic acids research 1989;17(13):5416.
1989: M Ludwig; Rainer Schwaab; A Eigel; Jürgen Horst; H Egli; Hans H Brackmann; K Olek
Identification of a single nucleotide C-to-T transition and five different deletions in patients with severe hemophilia B.
American journal of human genetics 1989;45(1):115-22.
1988: Rainer Schwaab; Johannes Oldenburg; M Higuchi; M Ludwig; L Kochhan; Jürgen Horst; Hans H Brackmann; H Egli; K Olek
Haemophilia A: carrier detection by DNA analysis.
Blut 1988;57(2):85-90.
1988: M Ludwig; Rainer Schwaab; K Olek; Hans H Brackmann; H Egli
Haemophilia B+ with inhibitor.
Thrombosis and haemostasis 1988;59(2):340.