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Manfred Schwab

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Kai-Oliver Henrich; Manfred Schwab; Frank Westermann
1p36 tumor suppression--a matter of dosage?
Lena M Brueckner; Elisa M Hess; Evgeny Sagulenko; Manfred Schwab; Diana Zheglo; Anne Blumrich; Larissa Savelyeva
Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.
E A Afanasyeva; Pieter Mestdagh; C Kumps; Jo Vandesompele; Volker Ehemann; J Theissen; Matthias Fischer; Marc Zapatka; Benedikt Brors; Larissa Savelyeva; Vitaliya Sagulenko; F Speleman; Manfred Schwab; Frank Westermann
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.

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All Publications

2012: Kai-Oliver Henrich; Manfred Schwab; Frank Westermann
1p36 tumor suppression--a matter of dosage?
Cancer research 2012;72(23):6079-88.
2012: Lena M Brueckner; Elisa M Hess; Evgeny Sagulenko; Manfred Schwab; Diana Zheglo; Anne Blumrich; Larissa Savelyeva
Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.
Human genetics 2012;131(8):1345-59.
2011: E A Afanasyeva; Pieter Mestdagh; C Kumps; Jo Vandesompele; Volker Ehemann; J Theissen; Matthias Fischer; Marc Zapatka; Benedikt Brors; Larissa Savelyeva; Vitaliya Sagulenko; F Speleman; Manfred Schwab; Frank Westermann
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
Cell death and differentiation 2011;18(6):974-84.
2011: Kai-Oliver Henrich; Tobias Bauer; Johannes Schulte; Volker Ehemann; Hedwig Deubzer; Sina Gogolin; Daniel Muth; Matthias Fischer; Axel Benner; Rainer König; Manfred Schwab; Frank Westermann
CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.
Cancer research 2011;71(8):3142-51.
2010: Daniel Muth; Seda Ghazaryan; Isabella Eckerle; Emily Beckett; Christina Pöhler; Julia Batzler; Claudia Beisel; Sina Gogolin; Matthias Fischer; Kai-Oliver Henrich; Volker Ehemann; Paul Gillespie; Manfred Schwab; Frank Westermann
Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma.
Cancer research 2010;70(9):3791-802.
2009: Isabella Eckerle; Daniel Muth; Julia Batzler; Kai-Oliver Henrich; Werner Lutz; Matthias Fischer; Olaf Witt; Manfred Schwab; Frank Westermann
Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.
Cancer letters 2009;285(1):99-107.
2009: Jessica Theissen; Marc Boensch; Rüdiger Spitz; David Betts; Sabine Stegmaier; Holger Christiansen; Felix Niggli; Freimut Schilling; Manfred Schwab; Thorsten Simon; Frank Westermann; Frank Berthold; Barbara Hero
Heterogeneity of the MYCN oncogene in neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):2085-90.
2008: Christian Praml; Wolfgang Schulz; Andreas Claas; Jan Mollenhauer; Annemarie Poustka; Rolf Ackermann; Manfred Schwab; Kai-Oliver Henrich
Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.
Cancer letters 2008;272(1):160-6.
2008: Vitalia Sagulenko; Daniel Muth; Evgeny Sagulenko; Tobias Paffhausen; Manfred Schwab; Frank Westermann
Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death.
Carcinogenesis 2008;29(10):1869-77.
2008: Hedwig E Deubzer; Volker Ehemann; Andreas E Kulozik; Frank Westermann; Larissa Savelyeva; Annette Kopp-Schneider; Daniel Riester; Manfred Schwab; Olaf Witt
Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro.
Cancer letters 2008;264(1):21-8.
2008: Hedwig E Deubzer; Volker Ehemann; Frank Westermann; Ralf Heinrich; Gunhild Mechtersheimer; Andreas E Kulozik; Manfred Schwab; Olaf Witt
Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells.
International journal of cancer. Journal international du cancer 2008;122(8):1891-900.
2008: Frank Westermann; Daniel Muth; Axel Benner; Tobias Bauer; Kai-Oliver Henrich; André Oberthuer; Benedikt Brors; Tim Beissbarth; Jo Vandesompele; Filip Pattyn; Barbara Hero; Rainer König; Matthias Fischer; Manfred Schwab
Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas.
Genome biology 2008;9(10):R150.
2007: Evgeny Sagulenko; Larissa Savelyeva; Volker Ehemann; Vitaliya Sagulenko; Wera Hofmann; Katrin Arnold; Andreas Claas; Siegfried Scherneck; Manfred Schwab
Suppression of polyploidy by the BRCA2 protein.
Cancer letters 2007;257(1):65-72.
2007: Małgorzata Sawińska; Jens Guido Schmitt; Evgeny Sagulenko; Frank Westermann; Manfred Schwab; Larissa Savelyeva
Novel aphidicolin-inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene.
Genes, chromosomes & cancer 2007;46(11):991-9.
2007: Frank Westermann; Kai-Oliver Henrich; Jun S Wei; Werner Lutz; Matthias Fischer; Rainer König; Ruprecht Wiedemeyer; Volker Ehemann; Benedikt Brors; Karen Ernestus; Ivo Leuschner; Axel Benner; Javed Khan; Manfred Schwab
High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4695-703.
2007: André Oberthuer; Patrick Warnat; Yvonne Kahlert; Frank Westermann; Rüdiger Spitz; Benedikt Brors; Barbara Hero; Roland Eils; Manfred Schwab; Frank Berthold; Matthias Fischer
Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease.
Cancer letters 2007;250(2):250-67.
2007: Anne Fechter; Isabel Buettel; Elisabeth Kuehnel; Manfred Schwab; Larissa Savelyeva
Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22.
International journal of cancer. Journal international du cancer 2007;120(11):2359-67.
2007: Tobias Paffhausen; Manfred Schwab; Frank Westermann
Targeted MYCN expression affects cytotoxic potential of chemotherapeutic drugs in neuroblastoma cells.
Cancer letters 2007;250(1):17-24.
2007: Fabiola Hormozian; Jens Guido Schmitt; Evgeny Sagulenko; Manfred Schwab; Larissa Savelyeva
FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD).
Cancer letters 2007;246(1-2):82-91.
2007: Kai-Oliver Henrich; Andreas Claas; Christian Praml; Axel Benner; Jan Mollenhauer; Annemarie Poustka; Manfred Schwab; Frank Westermann
Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma.
European journal of cancer (Oxford, England : 1990) 2007;43(3):607-16.
2007: Evgeny Suspitsin; Anna Sokolenko; Alexandr V Togo; Yulia R Lazareva; Elena A Turkevich; Dmitry E Matsko; Kai-Oliver Henrich; Anne-Lise Borresen-Dale; Manfred Schwab; Cees J Cornelisse; Evgeny N Imyanitov
Nonrandom distribution of oncogene amplifications in bilateral breast carcinomas: Possible role of host factors and survival bias.
International journal of cancer. Journal international du cancer 2007;120(2):297-302.
2007: Anne Fechter; Isabel Buettel; Elisabeth Kuehnel; Larissa Savelyeva; Manfred Schwab
Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions.
Genes, chromosomes & cancer 2007;46(1):98-106.
2006: André Oberthuer; Frank Berthold; Patrick Warnat; Barbara Hero; Yvonne Kahlert; Rüdiger Spitz; Karen Ernestus; Rainer König; Stefan Haas; Roland Eils; Manfred Schwab; Benedikt Brors; Frank Westermann; Matthias Fischer
Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(31):5070-8.
2006: Qing-Rong Chen; Sven Bilke; Jun S Wei; Braden T Greer; Seth M Steinberg; Frank Westermann; Manfred Schwab; Javed Khan
Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.
Genes, chromosomes & cancer 2006;45(9):856-62.
2006: Vasileios Askoxylakis; Walter Mier; Sabine Zitzmann; Volker Ehemann; Jianbing Zhang; Susanne Krämer; Carmen Beck; Manfred Schwab; Michael Eisenhut; Uwe Haberkorn
Characterization and development of a peptide (p160) with affinity for neuroblastoma cells.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(6):981-8.
2006: Larissa Savelyeva; Evgeny Sagulenko; Jens Guido Schmitt; Manfred Schwab
Low-frequency common fragile sites: link to neuropsychiatric disorders?
Cancer letters 2006;232(1):58-69.
2006: Kai-Oliver Henrich; Matthias Fischer; Daniel Mertens; Axel Benner; Ruprecht Wiedemeyer; Benedikt Brors; André Oberthuer; Frank Berthold; Jun S Wei; Javed Khan; Manfred Schwab; Frank Westermann
Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):131-8.
2006: Larissa Savelyeva; Evgeny Sagulenko; Jens Guido Schmitt; Manfred Schwab
The neurobeachin gene spans the common fragile site FRA13A.
Human genetics 2006;118(5):551-8.
2005: Sven Bilke; Qing-Rong Chen; Frank Westerman; Manfred Schwab; Daniel Catchpoole; Javed Khan
Inferring a tumor progression model for neuroblastoma from genomic data.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(29):7322-31.
2005: Vasileios Askoxylakis; Sabine Zitzmann; Walter Mier; Keith Graham; Susanne Krämer; Frederic von Wegner; Rainer H A Fink; Manfred Schwab; Michael Eisenhut; Uwe Haberkorn
Preclinical evaluation of the breast cancer cell-binding peptide, p160.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6705-12.
2004: Isabel Büttel; Anne Fechter; Manfred Schwab
Common fragile sites and cancer: targeted cloning by insertional mutagenesis.
Annals of the New York Academy of Sciences 2004;1028():14-27.
2004: Jun S Wei; Braden T Greer; Frank Westermann; Seth M Steinberg; Chang Gue Son; Qing-Rong Chen; Craig C Whiteford; Sven Bilke; Alexei L Krasnoselsky; Nicola Cenacchi; Daniel Catchpoole; Frank Berthold; Manfred Schwab; Javed Khan
Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma.
Cancer research 2004;64(19):6883-91.
2004: Qing-Rong Chen; Sven Bilke; Jun S Wei; Craig C Whiteford; Nicola Cenacchi; Alexei L Krasnoselsky; Braden T Greer; Chang Gue Son; Frank Westermann; Frank Berthold; Manfred Schwab; Daniel Catchpoole; Javed Khan
cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma.
BMC genomics 2004;5():70.
2004: Min-Kyoung Kim; Sabine Zitzmann; Frank Westermann; Katrin Arnold; Stefan Brouwers; Manfred Schwab; Larissa Savelyeva
Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2+/- carriers of familial breast cancer clusters.
Cancer letters 2004;210(1):85-94.
2004: Manfred Schwab
MYCN in neuronal tumours.
Cancer letters 2004;204(2):179-87.
2003: Isabel Wittke; Ruprecht Wiedemeyer; Andrea Pillmann; Larissa Savelyeva; Frank Westermann; Manfred Schwab
Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/Quiescin6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells.
Cancer research 2003;63(22):7742-52.
2003: Manfred Schwab; Frank Westermann; Barbara Hero; Frank Berthold
Neuroblastoma: biology and molecular and chromosomal pathology.
The lancet oncology 2003;4(8):472-80.
2003: Christian Praml; Larissa Savelyeva; Manfred Schwab
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Oncogene 2003;22(30):4765-73.
2003: Britta Mädge; Christoph Geisen; Tarik Möröy; Manfred Schwab
Yaf2 inhibits Myc biological function.
Cancer letters 2003;193(2):171-6.
2003: Isabel Matzner; Larissa Savelyeva; Manfred Schwab
Preferential integration of a transfected marker gene into spontaneously expressed fragile sites of a breast cancer cell line.
Cancer letters 2003;189(2):207-19.
2003: Ruprecht Wiedemeyer; Frank Westermann; Isabel Wittke; Joachim Nowock; Manfred Schwab
Ataxin-2 promotes apoptosis of human neuroblastoma cells.
Oncogene 2003;22(3):401-11.
2002: Bernd Berwanger; Oliver Hartmann; Eckhard Bergmann; Sandra Bernard; Dirk Nielsen; Michael Krause; Ali Kartal; Daniel Flynn; Ruprecht Wiedemeyer; Manfred Schwab; Helmut Schäfer; Holger Christiansen; Martin Eilers
Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.
Cancer cell 2002;2(5):377-86.
2002: Frank Westermann; Manfred Schwab
Genetic parameters of neuroblastomas.
Cancer letters 2002;184(2):127-47.
2002: Sabine Zitzmann; Volker Ehemann; Manfred Schwab
Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo.
Cancer research 2002;62(18):5139-43.
2002: Manfred Schwab
Amplified MYCN in human neuroblastoma: paradigm for the translation of molecular genetics to clinical oncology.
Annals of the New York Academy of Sciences 2002;963():63-73.
2002: Manfred Schwab; Andreas Claas; Larissa Savelyeva
BRCA2: a genetic risk factor for breast cancer.
Cancer letters 2002;175(1):1-8.
2001: J Zhang; Herbert Spring; Manfred Schwab
Neuroblastoma tumor cell-binding peptides identified through random peptide phage display.
Cancer letters 2001;171(2):153-64.
2001: Detlev Bannasch; Britta Mädge; Manfred Schwab
Functional interaction of Yaf2 with the central region of MycN.
Oncogene 2001;20(41):5913-9.
2001: Larissa Savelyeva; Andreas Claas; I Matzner; P Schlag; W Hofmann; Siegfried Scherneck; B Weber; Manfred Schwab
Constitutional genomic instability with inversions, duplications, and amplifications in 9p23-24 in BRCA2 mutation carriers.
Cancer research 2001;61(13):5179-85.
2001: A Bauer; Larissa Savelyeva; Andreas Claas; Christian Praml; Frank Berthold; Manfred Schwab
Smallest region of overlapping deletion in 1p36 in human neuroblastoma: a 1 Mbp cosmid and PAC contig.
Genes, chromosomes & cancer 2001;31(3):228-39.
2001: Larissa Savelyeva; Manfred Schwab
Amplification of oncogenes revisited: from expression profiling to clinical application.
Cancer letters 2001;167(2):115-23.
2001: Isabel Wittke; Britta Mädge; Ruprecht Wiedemeyer; A Kimchi; Manfred Schwab
DAP-5 is involved in MycN/IFNgamma-induced apoptosis in human neuroblastoma cells.
Cancer letters 2001;162(2):237-43.
2001: J Würfel; S Seiter; Marike J J G Stassar; Andreas Claas; R Kläs; M Rösel; Rachid Marhaba; Larissa Savelyeva; Manfred Schwab; Siegfried Matzku; Margot Zöller
Cloning of the human homologue of the metastasis-associated rat C4.4A.
Gene 2001;262(1-2):35-41.
2001: Andreas Claas; Larissa Savelyeva; Andrea Pillmann; Manfred Schwab
Chromosomal mapping of human genes by radioactive hybridization of cDNAs to CEPH-YAC high density gridded filter sets.
Cancer letters 2001;162(1):125-31.
2000: Andreas Claas; Larissa Savelyeva; Andrea Pillmann; Manfred Schwab
Chromosomal mapping of human genes by radioactive hybridization of cDNAs to Centre d'Etude du Polymorphisme humain high density gridded filter sets.
Cancer letters 2000;156(1):19-25.
2000: LC Amler; A Bauer; R Corvi; S Dihlmann; Christian Praml; W K Cavenee; Manfred Schwab; G M Hampton
Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP.
Genomics 2000;64(2):195-202.
1999: Detlev Bannasch; I Weis; Manfred Schwab
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN.
Oncogene 1999;18(48):6810-7.
1999: Detlev Bannasch; Manfred Schwab
A versatile bait vector allowing rapid isolation of prey vectors in Gal4-dependent yeast two-hybrid screens.
Plasmid 1999;42(2):139-43.
1999: H X An; Andreas Claas; Larissa Savelyeva; S Seitz; P Schlag; Siegfried Scherneck; Manfred Schwab
Two regions of deletion in 9p23-24 in sporadic breast cancer.
Cancer research 1999;59(16):3941-3.
1999: Manfred Schwab
Oncogene amplification in solid tumors.
Seminars in cancer biology 1999;9(4):319-25.
1999: Manfred Schwab
Human neuroblastoma: from basic science to clinical debut of cellular oncogenes.
Die Naturwissenschaften 1999;86(2):71-8.
1999: P Perri; Christian Praml; Larissa Savelyeva; Andrea Pillmann; Manfred Schwab
Fine mapping of distal 1p loci reveals TP73 at D1S468.
Cytogenetics and cell genetics 1999;84(1-2):111-4.
1999: Manfred Schwab
From fish to FISH: the comparative pathology of neuroblastomas in humans, mice and fish.
Journal of cancer research and clinical oncology 1999;125(3-4):141-9.
1999: Larissa Savelyeva; Andreas Claas; H An; Ruthild G Weber; Peter Lichter; Manfred Schwab
Retention of polysomy at 9p23-24 during karyotypic evolution in human breast cancer cell line COLO 824.
Genes, chromosomes & cancer 1999;24(1):87-93.
1998: Christian Praml; Larissa Savelyeva; P Perri; Manfred Schwab
Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells.
Cancer research 1998;58(22):5014-8.
1998: Christian Praml; LC Amler; S Dihlmann; Lothar Finke; P Schlag; Manfred Schwab
Secretory type II phospholipase A2 (PLA2G2A) expression status in colorectal carcinoma derived cell lines and in normal colonic mucosa.
Oncogene 1998;17(15):2009-12.
1998: Werner Lutz; Simone Fulda; Irmela Jeremias; Klaus-Michael Debatin; Manfred Schwab
MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.
Oncogene 1998;17(3):339-46.
1998: Manfred Schwab
Amplification of oncogenes in human cancer cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(6):473-9.
1998: Christoph Claas; S Seiter; Andreas Claas; Larissa Savelyeva; Manfred Schwab; Margot Zöller
Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy.
The Journal of cell biology 1998;141(1):267-80.
1998: Larissa Savelyeva; Andreas Claas; S Gier; P Schlag; Lothar Finke; J Mangion; Michael R Stratton; Manfred Schwab
An interstitial tandem duplication of 9p23-24 coexists with a mutation in the BRCA2 gene in the germ line of three brothers with breast cancer.
Cancer research 1998;58(5):863-6.
1997: Frank Berthold; K Sahin; Barbara Hero; H Christiansen; M Gehring; D Harms; S Horz; F Lampert; Manfred Schwab; J Terpe
The current contribution of molecular factors to risk estimation in neuroblastoma patients.
European journal of cancer (Oxford, England : 1990) 1997;33(12):2092-7.
1997: Werner Lutz; Manfred Schwab
In vivo regulation of single copy and amplified N-myc in human neuroblastoma cells.
Oncogene 1997;15(3):303-15.
1997: S Dihlmann; LC Amler; Manfred Schwab; A Wenzel
Variations in the expression of the adenomatous polyposis coli (APC) tumor suppressor gene in human cancer cell lines of different tissue origin.
Oncology research 1997;9(3):119-27.
1996: W Lutz; M Stöhr; J Schürmann; A Wenzel; A Löhr; Manfred Schwab
Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.
Oncogene 1996;13(4):803-12.
1996: Manfred Schwab; Christian Praml; LC Amler
Genomic instability in 1p and human malignancies.
Genes, chromosomes & cancer 1996;16(4):211-29.
1996: LC Amler; J Schürmann; Manfred Schwab
The DDX1 gene maps within 400 kbp 5' to MYCN and is frequently coamplified in human neuroblastoma.
Genes, chromosomes & cancer 1996;15(2):134-7.
1995: Christian Praml; Larissa Savelyeva; D Le Paslier; Linda D Siracusa; Arthur M Buchberg; Manfred Schwab; LC Amler
Human homologue of a candidate for the Mom1 locus, the secretory type II phospholipase A2 (PLA2S-II), maps to 1p35-36.1/D1S199.
Cancer research 1995;55(23):5504-6.
1995: M Gehring; F Berthold; L Edler; Manfred Schwab; LC Amler
The 1p deletion is not a reliable marker for the prognosis of patients with neuroblastoma.
Cancer research 1995;55(22):5366-9.
1995: Christian Praml; Lothar Finke; C Herfarth; P Schlag; Manfred Schwab; LC Amler
Deletion mapping defines different regions in 1p34.2-pter that may harbor genetic information related to human colorectal cancer.
Oncogene 1995;11(7):1357-62.
1995: R Corvi; Larissa Savelyeva; Manfred Schwab
Duplication of N-MYC at its resident site 2p24 may be a mechanism of activation alternative to amplification in human neuroblastoma cells.
Cancer research 1995;55(16):3471-4.
1995: LC Amler; R Corvi; Christian Praml; Larissa Savelyeva; D Le Paslier; Manfred Schwab
A reciprocal translocation (1;15) (36.2;q24) in a neuroblastoma cell line is accompanied by DNA duplication and may signal the site of a putative tumor suppressor-gene.
Oncogene 1995;10(6):1095-101.
1995: R Corvi; Larissa Savelyeva; Stephen Breit; A Wenzel; R Handgretinger; J Barak; M Oren; LC Amler; Manfred Schwab
Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma.
Oncogene 1995;10(6):1081-6.
1995: LC Amler; R Corvi; Christian Praml; Larissa Savelyeva; D Le Paslier; Manfred Schwab
Reciprocal translocation at 1p36.2/D1S160 in a neuroblastoma cell line: isolation of a YAC clone at the break.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):527-30.
1995: R Corvi; Larissa Savelyeva; LC Amler; R Handgretinger; Manfred Schwab
Cytogenetic evolution of MYCN and MDM2 amplification in the neuroblastoma LS tumour and its cell line.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):520-3.
1995: A Wenzel; Manfred Schwab
The mycN/max protein complex in neuroblastoma. Short review.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):516-9.
1994: Larissa Savelyeva; R Corvi; Manfred Schwab
Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells.
American journal of human genetics 1994;55(2):334-40.
1994: R Corvi; LC Amler; Larissa Savelyeva; M Gehring; Manfred Schwab
MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5523-7.
1994: Manfred Schwab
Human neuroblastoma: amplification of the N-myc oncogene and loss of a putative cancer-preventing gene on chromosome 1p.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1994;135():7-16.
1994: A Wenzel; Celina Cziepluch; J Schürmann; Manfred Schwab
The N-myc oncoprotein is a transcriptional activator and associates with max and RB1 proteins.
Progress in clinical and biological research 1994;385():59-66.
1994: Manfred Schwab
Where pathology meets molecular biology: N-myc amplification in human neuroblastoma as a paradigm for the clinical use of an oncogene alteration.
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():26-33.
1993: Peter Barker; Larissa Savelyeva; Manfred Schwab
Translocation junctions cluster at the distal short arm of chromosome 1 (1p36.1-2) in human neuroblastoma cells.
Oncogene 1993;8(12):3353-8.
1993: Celina Cziepluch; A Wenzel; J Schürmann; Manfred Schwab
Activation of gene transcription by the amino terminus of the N-Myc protein does not require association with the protein encoded by the retinoblastoma suppressor gene RB1.
Oncogene 1993;8(10):2833-8.
1993: Manfred Schwab
Genes, chromosomes and cancer. First meeting of the "Arbeitsgemeinschaft Molekular- und Zytogenetik (AEK)" of the Deutsche Krebsgesellschaft.
Journal of cancer research and clinical oncology 1993;119(7):434-8.
1992: Manfred Schwab
Molecular cytogenetics of human neuroblastoma.
Biochimica et biophysica acta 1992;1114(1):43-50.
1992: K van der Bosch; I Becker; Larissa Savelyeva; S Brüderlein; P Schlag; Manfred Schwab
Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell lines.
Genes, chromosomes & cancer 1992;5(1):91-5.
1992: LC Amler; Y Shibasaki; Larissa Savelyeva; Manfred Schwab
Amplification of the N-myc gene in human neuroblastomas: tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site.
Mutation research 1992;276(3):291-7.
1992: LC Amler; Manfred Schwab
Multiple amplicons of discrete sizes encompassing N-myc in neuroblastoma cells evolve through differential recombination from a large precursor DNA.
Oncogene 1992;7(4):807-9.
1991: A Wenzel; Celina Cziepluch; Ute Hamann; J Schürmann; Manfred Schwab
The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells.
The EMBO journal 1991;10(12):3703-12.
1991: Ute Hamann; A Wenzel; R Frank; Manfred Schwab
The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367.
Oncogene 1991;6(10):1745-51.
1991: D Zink; A Weith; T Martinsson; Manfred Schwab
Analysis of chromosome band 1p36 alterations by chromosomal in situ suppression hybridization with a microclone DNA bank.
Genes, chromosomes & cancer 1991;3(5):407-10.
1991: S Hiller; Stephen Breit; Z Q Wang; E F Wagner; Manfred Schwab
Localization of regulatory elements controlling human MYCN expression.
Oncogene 1991;6(6):969-77.
1991: Manfred Schwab
Is there a neuroblastoma anti-oncogene?
Progress in clinical and biological research 1991;366():1-9.
1991: Manfred Schwab
Enhanced expression of the cellular oncogene MYCN and progression of human neuroblastoma.
Advances in enzyme regulation 1991;31():329-38.
1990: I Leister; A Weith; S Brüderlein; Celina Cziepluch; D Kangwanpong; P Schlag; Manfred Schwab
Human colorectal cancer: high frequency of deletions at chromosome 1p35.
Cancer research 1990;50(22):7232-5.
1990: Manfred Schwab
Amplification of the MYCN oncogene and deletion of putative tumour suppressor gene in human neuroblastomas.
Brain pathology (Zurich, Switzerland) 1990;1(1):41-6.
1990: Lothar Schweigerer; Stephen Breit; A Wenzel; K Tsunamoto; R Ludwig; Manfred Schwab
Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.
Cancer research 1990;50(14):4411-6.
1990: Manfred Schwab
[Amplification of N-myc in neuroblastoma: paradigm for clinical use of an oncogene alteration].
Klinische Pädiatrie 1990;202(4):197-201.
1990: S Brüderlein; K van der Bosch; P Schlag; Manfred Schwab
Cytogenetics and DNA amplification in colorectal cancers.
Genes, chromosomes & cancer 1990;2(1):63-70.
1990: Manfred Schwab
Oncogene amplification in neoplastic development and progression of human cancers.
Critical reviews in oncogenesis 1990;2(1):35-51.
1990: Manfred Schwab; LC Amler
Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer.
Genes, chromosomes & cancer 1990;1(3):181-93.
1989: LC Amler; Manfred Schwab
Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA.
Molecular and cellular biology 1989;9(11):4903-13.
1989: A Weith; T Martinsson; Celina Cziepluch; S Brüderlein; LC Amler; F Berthold; Manfred Schwab
Neuroblastoma consensus deletion maps to 1p36.1-2.
Genes, chromosomes & cancer 1989;1(2):159-66.
1989: Stephen Breit; Manfred Schwab
Suppression of MYC by high expression of NMYC in human neuroblastoma cells.
Journal of neuroscience research 1989;24(1):21-8.
1989: T Martinsson; A Weith; Celina Cziepluch; Manfred Schwab
Chromosome 1 deletions in human neuroblastomas: generation and fine mapping of microclones from the distal 1p region.
Genes, chromosomes & cancer 1989;1(1):67-78.
1989: Manfred Schwab
Genetic principles of tumor suppression.
Biochimica et biophysica acta 1989;989(1):49-64.
1989: Manfred Schwab; R Oehlmann; S Brüderlein; Y Wakamatsu
Amplified DNA in cells of genetic melanoma of Xiphophorus.
Oncogene 1989;4(2):139-44.
1989: Manfred Schwab
Suppression of genetic melanoma in the fish Xiphophorus.
Ciba Foundation symposium 1989;142():181-97; discussion 197-8.
1989: Manfred Schwab
Genetic suppression of malignancy.
IARC scientific publications 1989;(96):239-54.
1988: Manfred Schwab; John M Bishop
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9585-9.