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Joan Blanchette-Mackie

Research Profile

Chemicals & Drugs

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Niemann-Pick Diseases

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Anthony T Craig; Oksana Gavrilova; Nancy K Dwyer; William Jou; Stephanie Pack; Eric Liu; Klaus Pechhold; Michael Schmidt; Victor J McAlister; John A Chiorini; E Joan Blanchette-Mackie; David M Harlan; Roland A Owens
Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
Tatsuro Kishida; Igor Kostetskii; Zhibing Zhang; Federico Martinez; Pei Liu; Steven U Walkley; Nancy K Dwyer; E Joan Blanchette-Mackie; Glenn L Radice; Jerome F Strauss
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.
Mei Zhang; M Sun; Nancy K Dwyer; Marcy Comly; Shutish C Patel; R Sundaram; John Hanover; E Joan Blanchette-Mackie
Differential trafficking of the Niemann-Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking.

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All Publications

2009: Anthony T Craig; Oksana Gavrilova; Nancy K Dwyer; William Jou; Stephanie Pack; Eric Liu; Klaus Pechhold; Michael Schmidt; Victor J McAlister; John A Chiorini; E Joan Blanchette-Mackie; David M Harlan; Roland A Owens
Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
Virology journal 2009;6():61.
2004: Tatsuro Kishida; Igor Kostetskii; Zhibing Zhang; Federico Martinez; Pei Liu; Steven U Walkley; Nancy K Dwyer; E Joan Blanchette-Mackie; Glenn L Radice; Jerome F Strauss
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.
The Journal of biological chemistry 2004;279(18):19276-85.
2003: Mei Zhang; M Sun; Nancy K Dwyer; Marcy Comly; Shutish C Patel; R Sundaram; John Hanover; E Joan Blanchette-Mackie
Differential trafficking of the Niemann-Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2003;92(443):63-73; discussion 45.
2002: Zhibing Zhang; Rossana Sapiro; David Kapfhamer; Maja Bucan; Jeff Bray; Vargheese Chennathukuzhi; Peter McNamara; Anne Curtis; Mei Zhang; E Joan Blanchette-Mackie; Jerome F Strauss
A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.
Molecular and cellular biology 2002;22(22):7993-8004.
2002: Mei Sun; Lanfeng Ma; Linda Xu; Jia Li; Wei Zhang; Gyorgy Petrovics; Mazen Makarem; Isabell A Sesterhenn; Mei Zhang; E Joan Blanchette-Mackie; Judd W Moul; Shiv Srivastava; Zhiqiang Zou
A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors.
Molecular medicine (Cambridge, Mass.) 2002;8(10):655-63.
2002: Mei Zhang; Pei Liu; Nancy K Dwyer; Lane K Christenson; Toshio Fujimoto; Federico Martinez; Marcy Comly; John Hanover; E Joan Blanchette-Mackie; Jerome F Strauss
MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria.
The Journal of biological chemistry 2002;277(36):33300-10.
2001: Mei Zhang; Nancy K Dwyer; Dona C Love; Adele Cooney; Marcy Comly; E Neufeld; Peter G Pentchev; E Joan Blanchette-Mackie; John Hanover
Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4466-71.
2001: Mei Zhang; Nancy K Dwyer; Edward B Neufeld; Dona C Love; Adele Cooney; Marcy Comly; S Patel; Hidemichi Watari; Jerome F Strauss; Peter G Pentchev; John Hanover; E Joan Blanchette-Mackie
Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes.
The Journal of biological chemistry 2001;276(5):3417-25.
2000: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; Michiko Watari; Christopher G Burd; Sapana Patel; Peter G Pentchev; Jerome F Strauss
Determinants of NPC1 expression and action: key promoter regions, posttranscriptional control, and the importance of a "cysteine-rich" loop.
Experimental cell research 2000;259(1):247-56.
2000: E Joan Blanchette-Mackie
Intracellular cholesterol trafficking: role of the NPC1 protein.
Biochimica et biophysica acta 2000;1486(1):171-83.
2000: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; Gwo-Shing Sun; J M Glick; Sapana Patel; Edward B Neufeld; Peter G Pentchev; Jerome F Strauss
NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis.
Experimental cell research 2000;255(1):56-66.
2000: Charles J Schultz; E Joan Blanchette-Mackie; R O Scow
Adrenal and liver in normal and cld/cld mice synthesize and secrete hepatic lipase, but the lipase is inactive in cld/cld mice.
Journal of lipid research 2000;41(2):214-25.
1999: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; Michiko Watari; Edward B Neufeld; Sapana Patel; Peter G Pentchev; Jerome F Strauss
Mutations in the leucine zipper motif and sterol-sensing domain inactivate the Niemann-Pick C1 glycoprotein.
The Journal of biological chemistry 1999;274(31):21861-6.
1999: Edward B Neufeld; Meryl E Wastney; S Patel; Subra Suresh; Adele Cooney; Nancy K Dwyer; C F Roff; K Ohno; JA Morris; ED Carstea; John P Incardona; Jerome F Strauss; marie T vanier; M C Patterson; Roscoe O Brady; Peter G Pentchev; E Joan Blanchette-Mackie
The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.
The Journal of biological chemistry 1999;274(14):9627-35.
1999: Shutish C Patel; Subra Suresh; Ujendra Kumar; Chang-Yong Hu; Adele Cooney; E Joan Blanchette-Mackie; Edward B Neufeld; Ramesh C Patel; Roscoe O Brady; Yogesh C Patel; Peter G Pentchev; Wei-Yi Ong
Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1657-62.
1999: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; J M Glick; Sapana Patel; Edward B Neufeld; Roscoe O Brady; Peter G Pentchev; Jerome F Strauss
Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):805-10.
1998: R O Scow; Charles J Schultz; J W Park; E Joan Blanchette-Mackie
Combined lipase deficiency (cld/cld) in mice affects differently post-translational processing of lipoprotein lipase, hepatic lipase and pancreatic lipase.
Chemistry and physics of lipids 1998;93(1-2):149-55.
1998: S Hasegawa; Griffin P Rodgers; Nancy K Dwyer; Constance Tom Noguchi; E Joan Blanchette-Mackie; N Uyesaka; Alan N Schechter; Eitan Fibach
Sickling of nucleated erythroid precursors from patients with sickle cell anemia.
Experimental hematology 1998;26(4):314-9.
1998: Raphael Schiffmann; Nancy K Dwyer; Irina A Lubensky; Maria Tsokos; V E Sutliff; J S Latimer; Karen P Frei; Roscoe O Brady; Norman W Barton; E Joan Blanchette-Mackie; Ehud Goldin
Constitutive achlorhydria in mucolipidosis type IV.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1207-12.
1997: Dawn L Brasaemle; T Barber; Nathan E Wolins; Ginette Serrero; E Joan Blanchette-Mackie; Constantine Londos
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein.
Journal of lipid research 1997;38(11):2249-63.
1997: Daniela Malide; Nancy K Dwyer; E Joan Blanchette-Mackie; Samuel W Cushman
Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(8):1083-96.
1997: Peter G Pentchev; E Joan Blanchette-Mackie; L Liscum
Biological implications of the Niemann-Pick C mutation.
Sub-cellular biochemistry 1997;28():437-51.
1996: Edward B Neufeld; Adele Cooney; J Pitha; E A Dawidowicz; Nancy K Dwyer; Peter G Pentchev; E Joan Blanchette-Mackie
Intracellular trafficking of cholesterol monitored with a cyclodextrin.
The Journal of biological chemistry 1996;271(35):21604-13.
1996: J W Park; E Joan Blanchette-Mackie; R O Scow
Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum.
The Biochemical journal 1996;317 ( Pt 1)():125-34.
1996: Constantine Londos; J Gruia-Gray; Dawn L Brasaemle; cristina Rondinone; T Takeda; Nancy K Dwyer; T Barber; Alan R Kimmel; E Joan Blanchette-Mackie
Perilipin: possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20 Suppl 3():S97-101.
1995: E Joan Blanchette-Mackie; Nancy K Dwyer; T Barber; R A Coxey; T Takeda; cristina Rondinone; J L Theodorakis; A S Greenberg; Constantine Londos
Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.
Journal of lipid research 1995;36(6):1211-26.
1995: Ehud Goldin; E Joan Blanchette-Mackie; Nancy K Dwyer; Peter G Pentchev; Roscoe O Brady
Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent.
Pediatric research 1995;37(6):687-92.
1994: Daniele Szapary; T Barber; Nancy K Dwyer; E Joan Blanchette-Mackie; S Stoney Simons
Microtubules are not required for glucocorticoid receptor mediated gene induction.
The Journal of steroid biochemistry and molecular biology 1994;51(3-4):143-8.
1994: P G Pentchev; E Joan Blanchette-Mackie; E A Dawidowicz
The NP-C gene: a key to pathways of intracellular cholesterol transport.
Trends in cell biology 1994;4(10):365-9.
1994: Peter G Pentchev; Roscoe O Brady; E Joan Blanchette-Mackie; marie T vanier; ED Carstea; C C Parker; Ehud Goldin; C F Roff
The Niemann-Pick C lesion and its relationship to the intracellular distribution and utilization of LDL cholesterol.
Biochimica et biophysica acta 1994;1225(3):235-43.
1994: F F Chao; E Joan Blanchette-Mackie; B F Dickens; W Gamble; Howard S Kruth
Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.
Journal of lipid research 1994;35(1):71-83.
1993: R A Coxey; Peter G Pentchev; G Campbell; E Joan Blanchette-Mackie
Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: a cytochemical freeze-fracture study.
Journal of lipid research 1993;34(7):1165-76.
1993: O C Martin; M E Comly; E Joan Blanchette-Mackie; Peter G Pentchev; Richard E Pagano
Cholesterol deprivation affects the fluorescence properties of a ceramide analog at the Golgi apparatus of living cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2661-5.
1992: R O Scow; E Joan Blanchette-Mackie
Endothelium, the dynamic interface in cardiac lipid transport.
Molecular and cellular biochemistry 1992;116(1-2):181-91.
1992: Hiroshi Masuno; E Joan Blanchette-Mackie; Charles J Schultz; A E Spaeth; R O Scow; Hiromichi Okuda
Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine.
Journal of lipid research 1992;33(9):1343-9.
1992: F F Chao; E Joan Blanchette-Mackie; V V Tertov; S I Skarlatos; Y J Chen; Howard S Kruth
Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome.
The Journal of biological chemistry 1992;267(7):4992-8.
1991: R O Scow; E Joan Blanchette-Mackie
Transport of fatty acids and monoacylglycerols in white and brown adipose tissues.
Brain research bulletin 1991;27(3-4):487-91.
1991: Hiroshi Masuno; Charles J Schultz; J W Park; E Joan Blanchette-Mackie; C Mateo; R O Scow
Glycosylation, activity and secretion of lipoprotein lipase in cultured brown adipocytes of newborn mice. Effect of tunicamycin, monensin, 1-deoxymannojirimycin and swainsonine.
The Biochemical journal 1991;277 ( Pt 3)():801-9.
1991: A S Greenberg; J J Egan; S A Wek; N B Garty; E Joan Blanchette-Mackie; Constantine Londos
Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.
The Journal of biological chemistry 1991;266(17):11341-6.
1991: E Joan Blanchette-Mackie
Lipoprotein lipase and fatty acid transport in heart, adipose tissue and mammary gland: immuno and cytochemistry.
Endocrine regulations 1991;25(1-2):63-9.
1990: C E Argoff; Christine R Kaneski; E Joan Blanchette-Mackie; M Comly; Nancy K Dwyer; A Brown; Roscoe O Brady; Peter G Pentchev
Type C Niemann-Pick disease: documentation of abnormal LDL processing in lymphocytes.
Biochemical and biophysical research communications 1990;171(1):38-45.
1990: Hiroshi Masuno; E Joan Blanchette-Mackie; S S Chernick; R O Scow
Synthesis of inactive nonsecretable high mannose-type lipoprotein lipase by cultured brown adipocytes of combined lipase-deficient cld/cld mice.
The Journal of biological chemistry 1990;265(3):1628-38.
1990: F F Chao; E Joan Blanchette-Mackie; Y J Chen; B F Dickens; E Berlin; L M Amende; S I Skarlatos; W Gamble; James Resau; W T Mergner
Characterization of two unique cholesterol-rich lipid particles isolated from human atherosclerotic lesions.
The American journal of pathology 1990;136(1):169-79.
1989: E Joan Blanchette-Mackie; Nancy K Dwyer; marie T vanier; J Sokol; H F Merrick; M E Comly; C E Argoff; Peter G Pentchev
Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts.
Biochimica et biophysica acta 1989;1006(2):219-26.
1989: E Joan Blanchette-Mackie; Hiroshi Masuno; Nancy K Dwyer; Thomas Olivecrona; R O Scow
Lipoprotein lipase in myocytes and capillary endothelium of heart: immunocytochemical study.
The American journal of physiology 1989;256(6 Pt 1):E818-28.
1989: E Joan Blanchette-Mackie; Nancy K Dwyer; L A Amende
Cytochemical studies of lipid metabolism: immunogold probes for lipoprotein lipase and cholesterol.
The American journal of anatomy 1989;185(2-3):255-63.
1988: E Joan Blanchette-Mackie; Nancy K Dwyer; L M Amende; Howard S Kruth; J D Butler; J Sokol; M E Comly; marie T vanier; Thomas August; Roscoe O Brady
Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8022-6.
1988: S I Skarlatos; L M Amende; F F Chao; E Joan Blanchette-Mackie; W Gamble; Howard S Kruth
Biochemical characterization of isolated cholesterol-phospholipid particles continuously released from rat and human platelets after activation.
Laboratory investigation; a journal of technical methods and pathology 1988;59(3):344-52.
1988: F F Chao; L M Amende; E Joan Blanchette-Mackie; S I Skarlatos; W Gamble; James Resau; W T Mergner; Howard S Kruth
Unesterified cholesterol-rich lipid particles in atherosclerotic lesions of human and rabbit aortas.
The American journal of pathology 1988;131(1):73-83.
1988: G M Swartz; M K Gentry; L M Amende; E Joan Blanchette-Mackie; Carl R Alving
Antibodies to cholesterol.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1902-6.
1987: E Joan Blanchette-Mackie; L M Amende
Electron microscopic visualization of fatty acids in tissues.
Journal of electron microscopy technique 1987;7(3):205-21.
1987: L M Amende; S S Chernick; G F Reed; E Joan Blanchette-Mackie
Effect of heparin on membrane associated clathrin basketwork of cultured cells derived from the stromal-vascular fraction of mouse brown adipose tissue.
Cell biology international reports 1987;11(9):637-44.
1986: E Joan Blanchette-Mackie; M G Wetzel; S S Chernick; J R Paterniti; W Virgil Brown; R O Scow
Effect of the combined lipase deficiency mutation (cld/cld) on ultrastructure of tissues in mice. Diaphragm, heart, brown adipose tissue, lung, and liver.
Laboratory investigation; a journal of technical methods and pathology 1986;55(3):347-62.
1986: L M Amende; E Joan Blanchette-Mackie; R O Scow
Demonstration of fatty acid domains in membranes produced by lipolysis in mouse adipose tissue. A freeze-fracture study.
Cell and tissue research 1986;246(3):495-508.
1986: E Joan Blanchette-Mackie; T Briggs; S S Chernick; R O Scow
Lipolysis of serum-activated triacylglycerol at the surface of J774.1 macrophages. A biochemical--electron-microscopic study.
Cell and tissue research 1986;244(1):95-105.
1985: L M Amende; E Joan Blanchette-Mackie; S S Chernick; R O Scow
Effect of pH on visualization of fatty acids as myelin figures in mouse adipose tissue by freeze-fracture electron microscopy.
Biochimica et biophysica acta 1985;837(1):94-102.
1985: E Joan Blanchette-Mackie; R O Scow
Lipid filling and lipolysis in adipose tissue and cells.
International journal of obesity 1985;9 Suppl 1():7-14.
1985: R O Scow; E Joan Blanchette-Mackie
Why fatty acids flow in cell membranes.
Progress in lipid research 1985;24(3):197-241.
1984: A Reinilä; E Joan Blanchette-Mackie; R O Scow
Uptake of plasma triacylglycerol by a muscular artery in the rat: an ultrastructural study.
Virchows Archiv. B, Cell pathology including molecular pathology 1984;47(1):67-78.
1983: E Joan Blanchette-Mackie; R O Scow
Movement of lipolytic products to mitochondria in brown adipose tissue of young rats: an electron microscope study.
Journal of lipid research 1983;24(3):229-44.
1982: E Joan Blanchette-Mackie; R O Scow
Continuity of intracellular channels with extracellular space in adipose tissue and liver: demonstrated with tannic acid and lanthanum.
The Anatomical record 1982;203(2):205-19.
1981: E Joan Blanchette-Mackie; R O Scow
Lipolysis and lamellar structures in white adipose tissue of young rats: lipid movement in membranes.
Journal of ultrastructure research 1981;77(3):295-318.
1981: E Joan Blanchette-Mackie; R O Scow
Membrane continuities within cells and intercellular contacts in white adipose tissue of young rats.
Journal of ultrastructure research 1981;77(3):277-94.
1980: R O Scow; E Joan Blanchette-Mackie; Louis C Smith
Transport of lipid across capillary endothelium.
Federation proceedings 1980;39(9):2610-7.