Michael Schwartz

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Enns Linda C; Morton John F; Mangalindan Ruby Sue; McKnight G Stanley; Schwartz Michael W; Kaeberlein Matt R; Kennedy Brian K; Rabinovitch Peter S; Ladiges Warren C
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.
Wisse Brent E; Schwartz Michael W
Does hypothalamic inflammation cause obesity?
German Jonathan; Kim Francis; Schwartz Gary J; Havel Peter J; Rhodes Christopher J; Schwartz Michael W; Morton Gregory J
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.

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All Publications

2009: Enns Linda C; Morton John F; Mangalindan Ruby Sue; McKnight G Stanley; Schwartz Michael W; Kaeberlein Matt R; Kennedy Brian K; Rabinovitch Peter S; Ladiges Warren C
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(12):1221-31.
2009: Wisse Brent E; Schwartz Michael W
Does hypothalamic inflammation cause obesity?
Cell metabolism 2009;10(4):241-2.
2009: German Jonathan; Kim Francis; Schwartz Gary J; Havel Peter J; Rhodes Christopher J; Schwartz Michael W; Morton Gregory J
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
Endocrinology 2009;150(10):4502-11.
2009: Maloney Ezekiel; Sweet Ian R; Hockenbery David M; Pham Matilda; Rizzo Norma O; Tateya Sanshiro; Handa Priya; Schwartz Michael W; Kim Francis
Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1370-5.
2009: Pamir Nathalie; McMillen Timothy S; Kaiyala Karl J; Schwartz Michael W; LeBoeuf Renée C
Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status.
Endocrinology 2009;150(9):4124-34.
2009: Schur E A; Kleinhans N M; Goldberg J; Buchwald D; Schwartz M W; Maravilla K
Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus.
International journal of obesity (2005) 2009;33(6):653-61.
2009: Sweet I R; Gilbert M; Maloney E; Hockenbery D M; Schwartz M W; Kim F
Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration.
Diabetologia 2009;52(5):921-31.
2009: Sarruf David A; Yu Fang; Nguyen Hong T; Williams Diana L; Printz Richard L; Niswender Kevin D; Schwartz Michael W
Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis.
Endocrinology 2009;150(2):707-12.
2008: Kim Francis; Pham Matilda; Maloney Ezekiel; Rizzo Norma O; Morton Gregory J; Wisse Brent E; Kirk Elizabeth A; Chait Alan; Schwartz Michael W
Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(11):1982-8.
2008: Williams Diana L; Schwartz Michael W; Bastian L Scot; Blevins James E; Baskin Denis G
Immunocytochemistry and laser capture microdissection for real-time quantitative PCR identify hindbrain neurons activated by interaction between leptin and cholecystokinin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008;56(3):285-93.
2007: Wisse Brent E; Kim Francis; Schwartz Michael W
Physiology. An integrative view of obesity.
Science (New York, N.Y.) 2007;318(5852):928-9.
2007: Wisse Brent E; Ogimoto Kayoko; Tang Jingjing; Harris Marvin K; Raines Elaine W; Schwartz Michael W
Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals.
Endocrinology 2007;148(11):5230-7.
2007: Kim Francis; Pham Matilda; Luttrell Ian; Bannerman Douglas D; Tupper Joan; Thaler Joshua; Hawn Thomas R; Raines Elaine W; Schwartz Michael W
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.
Circulation research 2007;100(11):1589-96.
2007: Wisse Brent E; Ogimoto Kayoko; Morton Gregory J; Williams Diana L; Schwartz Michael W
Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance.
Brain research 2007;1144():101-6.
2006: Williams Diana L; Baskin Denis G; Schwartz Michael W
Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation.
Diabetes 2006;55(12):3387-93.
2006: Kaelin Christopher B; Gong Lijie; Xu Allison Wanting; Yao Fayi; Hockman Kristin; Morton Gregory J; Schwartz Michael W; Barsh Gregory S; MacKenzie Robert G
Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2591-602.
2006: Morton G J; Cummings D E; Baskin D G; Barsh G S; Schwartz M W
Central nervous system control of food intake and body weight.
Nature 2006;443(7109):289-95.
2006: Pardini Aaron W; Nguyen Hong T; Figlewicz Dianne P; Baskin Denis G; Williams Diana L; Kim Francis; Schwartz Michael W
Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis.
Brain research 2006;1112(1):169-78.
2006: Schwartz Michael W
Central nervous system regulation of food intake.
Obesity (Silver Spring, Md.) 2006;14 Suppl 1():1S-8S.
2006: Wisse Brent E; Ogimoto Kayoko; Schwartz Michael W
Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins.
Peptides 2006;27(2):265-73.
2006: Gelling Richard W; Morton Gregory J; Morrison Christopher D; Niswender Kevin D; Myers Martin G; Rhodes Christopher J; Schwartz Michael W
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Cell metabolism 2006;3(1):67-73.
2005: Morton Gregory J; Gelling Richard W; Niswender Kevin D; Morrison Christopher D; Rhodes Christopher J; Schwartz Michael W
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
Cell metabolism 2005;2(6):411-20.
2005: Xu Allison Wanting; Kaelin Christopher B; Morton Gregory J; Ogimoto Kayoko; Stanhope Kimber; Graham James; Baskin Denis G; Havel Peter; Schwartz Michael W; Barsh Gregory S
Effects of hypothalamic neurodegeneration on energy balance.
PLoS biology 2005;3(12):e415.
2005: Morrison Christopher D; Morton Gregory J; Niswender Kevin D; Gelling Richard W; Schwartz Michael W
Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E1051-7.
2005: Sindelar Dana K; Palmiter Richard D; Woods Stephen C; Schwartz Michael W
Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y.
Peptides 2005;26(12):2597-602.
2005: Fishel Mark A; Watson G Stennis; Montine Thomas J; Wang Qin; Green Pattie S; Kulstad J Jacob; Cook David G; Peskind Elaine R; Baker Laura D; Goldgaber Dmitry; Nie Wei; Asthana Sanjay; Plymate Stephen R; Schwartz Michael W; Craft Suzanne
Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults.
Archives of neurology 2005;62(10):1539-44.
2005: Kim Francis; Tysseling Kelly A; Rice Julie; Gallis Byron; Haji Lutfiyah; Giachelli Cecilia M; Raines Elaine W; Corson Marshall A; Schwartz Michael W
Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells.
Journal of molecular and cellular cardiology 2005;39(2):327-34.
2005: Williams Diana L; Schwartz Michael W
Out of synch: Clock mutation causes obesity in mice.
Cell metabolism 2005;1(6):355-6.
2005: Porte Daniel; Baskin Denis G; Schwartz Michael W
Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans.
Diabetes 2005;54(5):1264-76.
2005: Xu Allison Wanting; Kaelin Christopher B; Takeda Kiyoshi; Akira Shizuo; Schwartz Michael W; Barsh Gregory S
PI3K integrates the action of insulin and leptin on hypothalamic neurons.
The Journal of clinical investigation 2005;115(4):951-8.
2005: Morton Gregory J; Blevins James E; Williams Diana L; Niswender Kevin D; Gelling Richard W; Rhodes Christopher J; Baskin Denis G; Schwartz Michael W
Leptin action in the forebrain regulates the hindbrain response to satiety signals.
The Journal of clinical investigation 2005;115(3):703-10.
2005: Schwartz Michael W; Porte Daniel
Diabetes, obesity, and the brain.
Science (New York, N.Y.) 2005;307(5708):375-9.
2004: Schwartz Michael W; Niswender Kevin D
Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance?
The Journal of clinical endocrinology and metabolism 2004;89(12):5889-97.
2004: Wisse Brent E; Ogimoto Kayoko; Morton Gregory J; Wilkinson Charles W; Frayo R Scott; Cummings David E; Schwartz Michael W
Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis.
American journal of physiology. Endocrinology and metabolism 2004;287(6):E1107-13.
2004: Niswender Kevin D; Baskin Denis G; Schwartz Michael W
Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis.
Trends in endocrinology and metabolism: TEM 2004;15(8):362-9.
2004: Gelling Richard W; Overduin Joost; Morrison Christopher D; Morton Gregory J; Frayo R Scott; Cummings David E; Schwartz Michael W
Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding.
Endocrinology 2004;145(10):4575-82.
2004: Sindelar Dana K; Ste Marie Linda; Miura Grant I; Palmiter Richard D; McMinn Julie E; Morton Gregory J; Schwartz Michael W
Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia.
Endocrinology 2004;145(7):3363-8.
2004: Blevins James E; Schwartz Michael W; Baskin Denis G
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(1):R87-96.
2004: Morton Gregory J; Mystkowski Paul; Matsumoto Alvin M; Schwartz Michael W
Increased hypothalamic melanin concentrating hormone gene expression during energy restriction involves a melanocortin-independent, estrogen-sensitive mechanism.
Peptides 2004;25(4):667-74.
2003: Blevins James E; Eakin Thomas J; Murphy Joyce A; Schwartz Michael W; Baskin Denis G
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin.
Brain research 2003;993(1-2):30-41.
2003: Drazen Deborah L; Wortman Matthew D; Schwartz Michael W; Clegg Deborah J; van Dijk Gertjan; Woods Stephen C; Seeley Randy J
Adrenalectomy alters the sensitivity of the central nervous system melanocortin system.
Diabetes 2003;52(12):2928-34.
2003: Wisse Brent E; Schwartz Michael W; Cummings David E
Melanocortin signaling and anorexia in chronic disease states.
Annals of the New York Academy of Sciences 2003;994():275-81.
2003: Watson G S; Peskind E R; Asthana S; Purganan K; Wait C; Chapman D; Schwartz M W; Plymate S; Craft S
Insulin increases CSF Abeta42 levels in normal older adults.
Neurology 2003;60(12):1899-903.
2003: Morton Gregory J; Niswender Kevin D; Rhodes Christopher J; Myers Martin G; Blevins James E; Baskin Denis G; Schwartz Michael W
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
Endocrinology 2003;144(5):2016-24.
2003: Niswender Kevin D; Gallis Byron; Blevins James E; Corson Marshall A; Schwartz Michael W; Baskin Denis G
Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(3):275-83.
2003: Schwartz Michael W; Woods Stephen C; Seeley Randy J; Barsh Gregory S; Baskin Denis G; Leibel Rudolph L
Is the energy homeostasis system inherently biased toward weight gain?
Diabetes 2003;52(2):232-8.
2003: Niswender Kevin D; Morrison Christopher D; Clegg Deborah J; Olson Ryan; Baskin Denis G; Myers Martin G; Seeley Randy J; Schwartz Michael W
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia.
Diabetes 2003;52(2):227-31.
2003: Niswender Kevin D; Schwartz Michael W
Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities.
Frontiers in neuroendocrinology 2003;24(1):1-10.
2003: Woods Stephen C; Seeley Randy J; Baskin Denis G; Schwartz Michael W
Insulin and the blood-brain barrier.
Current pharmaceutical design 2003;9(10):795-800.
2003: Cummings David E; Schwartz Michael W
Genetics and pathophysiology of human obesity.
Annual review of medicine 2003;54():453-71.
2002: Porte Daniel; Baskin Denis G; Schwartz Michael W
Leptin and insulin action in the central nervous system.
Nutrition reviews 2002;60(10 Pt 2):S20-9; discussion S68-84, 85-7.
2002: Barsh Gregory S; Schwartz Michael W
Genetic approaches to studying energy balance: perception and integration.
Nature reviews. Genetics 2002;3(8):589-600.
2002: Cummings David E; Clement Karine; Purnell Jonathan Q; Vaisse Christian; Foster Karen E; Frayo R Scott; Schwartz Michael W; Basdevant Arnaud; Weigle David S
Elevated plasma ghrelin levels in Prader Willi syndrome.
Nature medicine 2002;8(7):643-4.
2002: Blevins James E; Schwartz Michael W; Baskin Denis G
Peptide signals regulating food intake and energy homeostasis.
Canadian journal of physiology and pharmacology 2002;80(5):396-406.
2002: Schwartz M W
Neuronal pathways regulating food intake and body adiposity.
Annales d'endocrinologie 2002;63(2 Pt 1):117-20.
2002: Sindelar Dana K; Mystkowski Paul; Marsh Donald J; Palmiter Richard D; Schwartz Michael W
Attenuation of diabetic hyperphagia in neuropeptide Y--deficient mice.
Diabetes 2002;51(3):778-83.
2002: Grill Harvey J; Schwartz Michael W; Kaplan Joel M; Foxhall James S; Breininger John; Baskin Denis G
Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake.
Endocrinology 2002;143(1):239-46.
2001: Morton G J; Schwartz M W
The NPY/AgRP neuron and energy homeostasis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25 Suppl 5():S56-62.
2001: Niswender K D; Morton G J; Stearns W H; Rhodes C J; Myers M G; Schwartz M W
Intracellular signalling. Key enzyme in leptin-induced anorexia.
Nature 2001;413(6858):794-5.
2001: Schwartz M W
Progress in the search for neuronal mechanisms coupling type 2 diabetes to obesity.
The Journal of clinical investigation 2001;108(7):963-4.
2001: Wisse B E; Schwartz M W
Role of melanocortins in control of obesity.
Lancet 2001;358(9285):857-9.
2001: Wisse B E; Frayo R S; Schwartz M W; Cummings D E
Reversal of cancer anorexia by blockade of central melanocortin receptors in rats.
Endocrinology 2001;142(8):3292-301.
2001: Adage T; Scheurink A J; de Boer S F; de Vries K; Konsman J P; Kuipers F; Adan R A; Baskin D G; Schwartz M W; van Dijk G
Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3639-45.
2001: Baskin D G; Blevins J E; Schwartz M W
How the brain regulates food intake and body weight: the role of leptin.
Journal of pediatric endocrinology & metabolism : JPEM 2001;14 Suppl 6():1417-29.
2000: McMinn J E; Sindelar D K; Havel P J; Schwartz M W
Leptin deficiency induced by fasting impairs the satiety response to cholecystokinin.
Endocrinology 2000;141(12):4442-8.
2000: Mystkowski P; Seeley R J; Hahn T M; Baskin D G; Havel P J; Matsumoto A M; Wilkinson C W; Peacock-Kinzig K; Blake K A; Schwartz M W
Hypothalamic melanin-concentrating hormone and estrogen-induced weight loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(22):8637-42.
2000: Schwartz M W
Biomedicine. Staying slim with insulin in mind.
Science (New York, N.Y.) 2000;289(5487):2066-7.
2000: Kaiyala K J; Prigeon R L; Kahn S E; Woods S C; Schwartz M W
Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.
Diabetes 2000;49(9):1525-33.
2000: Baskin D G; Breininger J F; Schwartz M W
SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats.
Regulatory peptides 2000;92(1-3):9-15.
2000: McMinn J E; Wilkinson C W; Havel P J; Woods S C; Schwartz M W
Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(2):R695-703.
2000: Hagan M M; Rushing P A; Pritchard L M; Schwartz M W; Strack A M; Van Der Ploeg L H; Woods S C; Seeley R J
Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(1):R47-52.
2000: Mystkowski P; Shankland E; Schreyer S A; LeBoeuf R C; Schwartz R S; Cummings D E; Kushmerick M; Schwartz M W
Validation of whole-body magnetic resonance spectroscopy as a tool to assess murine body composition.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(6):719-24.
2000: McMinn J E; Baskin D G; Schwartz M W
Neuroendocrine mechanisms regulating food intake and body weight.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2000;1(1):37-46.
2000: Benoit S C; Schwartz M W; Lachey J L; Hagan M M; Rushing P A; Blake K A; Yagaloff K A; Kurylko G; Franco L; Danhoo W; Seeley R J
A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3442-8.
2000: Schwartz M W; Woods S C; Porte D; Seeley R J; Baskin D G
Central nervous system control of food intake.
Nature 2000;404(6778):661-71.
2000: Havel P J; Hahn T M; Sindelar D K; Baskin D G; Dallman M F; Weigle D S; Schwartz M W
Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.
Diabetes 2000;49(2):244-52.
2000: Porte D; Seeley R J; Woods S C; Baskin D G; Figlewicz D P; Schwartz M W
Comments on the relation among GAD-65, IA-2 antibodies and body adiposity.
Diabetologia 2000;43(1):134.
1999: Baskin D G; Figlewicz Lattemann D; Seeley R J; Woods S C; Porte D; Schwartz M W
Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight.
Brain research 1999;848(1-2):114-23.
1999: Marsh D J; Miura G I; Yagaloff K A; Schwartz M W; Barsh G S; Palmiter R D
Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues.
Brain research 1999;848(1-2):66-77.
1999: Kaiyala K J; Prigeon R L; Kahn S E; Woods S C; Porte D; Schwartz M W
Reduced beta-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding.
The American journal of physiology 1999;277(4 Pt 1):E659-67.
1999: Sindelar D K; Havel P J; Seeley R J; Wilkinson C W; Woods S C; Schwartz M W
Low plasma leptin levels contribute to diabetic hyperphagia in rats.
Diabetes 1999;48(6):1275-80.
1999: Baskin D G; Hahn T M; Schwartz M W
Leptin sensitive neurons in the hypothalamus.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(5):345-50.
1999: van Dijk G; Seeley R J; Thiele T E; Friedman M I; Ji H; Wilkinson C W; Burn P; Campfield L A; Tenenbaum R; Baskin D G; Woods S C; Schwartz M W
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat.
The American journal of physiology 1999;276(5 Pt 2):R1425-33.
1999: Schwartz M W; Baskin D G; Kaiyala K J; Woods S C
Model for the regulation of energy balance and adiposity by the central nervous system.
The American journal of clinical nutrition 1999;69(4):584-96.
1999: Baskin D G; Breininger J F; Schwartz M W
Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.
Diabetes 1999;48(4):828-33.
1999: Hagan M M; Rushing P A; Schwartz M W; Yagaloff K A; Burn P; Woods S C; Seeley R J
Role of the CNS melanocortin system in the response to overfeeding.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(6):2362-7.
1999: Baskin D G; Schwartz M W; Seeley R J; Woods S C; Porte D; Breininger J F; Jonak Z; Schaefer J; Krouse M; Burghardt C; Campfield L A; Burn P; Kochan J P
Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(3):353-62.
1999: Seeley R J; Schwartz M W
Neuroendocrine regulation of food intake.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1999;88(428):58-61.
1998: McMinn J E; Seeley R J; Wilkinson C W; Havel P J; Woods S C; Schwartz M W
NPY-induced overfeeding suppresses hypothalamic NPY mRNA expression: potential roles of plasma insulin and leptin.
Regulatory peptides 1998;75-76():425-31.
1998: Porte D; Seeley R J; Woods S C; Baskin D G; Figlewicz D P; Schwartz M W
Obesity, diabetes and the central nervous system.
Diabetologia 1998;41(8):863-81.
1998: Woods S C; Seeley R J; Porte D; Schwartz M W
Signals that regulate food intake and energy homeostasis.
Science (New York, N.Y.) 1998;280(5368):1378-83.
1998: Schwartz M W; Erickson J C; Baskin D G; Palmiter R D
Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene.
Endocrinology 1998;139(5):2629-35.
1998: Baskin D G; Seeley R J; Kuijper J L; Lok S; Weigle D S; Erickson J C; Palmiter R D; Schwartz M W
Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting.
Diabetes 1998;47(4):538-43.
1998: Weigle D S; Selfridge L E; Schwartz M W; Seeley R J; Cummings D E; Havel P J; Kuijper J L; BeltrandelRio H
Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting.
Diabetes 1998;47(2):298-302.
1998: Craft S; Peskind E; Schwartz M W; Schellenberg G D; Raskind M; Porte D
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.
Neurology 1998;50(1):164-8.
1998: Palmiter R D; Erickson J C; Hollopeter G; Baraban S C; Schwartz M W
Life without neuropeptide Y.
Recent progress in hormone research 1998;53():163-99.
1997: Schwartz M W; Seeley R J; Woods S C; Weigle D S; Campfield L A; Burn P; Baskin D G
Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.
Diabetes 1997;46(12):2119-23.
1997: Seeley R J; Yagaloff K A; Fisher S L; Burn P; Thiele T E; van Dijk G; Baskin D G; Schwartz M W
Melanocortin receptors in leptin effects.
Nature 1997;390(6658):349.
1997: Schwartz M W; Strack A M; Dallman M F
Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes.
Regulatory peptides 1997;72(2-3):105-12.
1997: Schwartz M W; Prigeon R L; Kahn S E; Nicolson M; Moore J; Morawiecki A; Boyko E J; Porte D
Evidence that plasma leptin and insulin levels are associated with body adiposity via different mechanisms.
Diabetes care 1997;20(9):1476-81.
1997: Chavez M; Seeley R J; Green P K; Wilkinson C W; Schwartz M W; Woods S C
Adrenalectomy increases sensitivity to central insulin.
Physiology & behavior 1997;62(3):631-4.
1997: Schwartz M W; Seeley R J; Woods S C
Wasting illness as a disorder of body weight regulation.
The Proceedings of the Nutrition Society 1997;56(2):785-91.
1997: Schwartz M W
Regulation of appetite and body weight.
Hospital practice (1995) 1997;32(7):109-12, 117-9.
1997: Schwartz M W; Seeley R J
Seminars in medicine of the Beth Israel Deaconess Medical Center. Neuroendocrine responses to starvation and weight loss.
The New England journal of medicine 1997;336(25):1802-11.
1996: Seeley R J; van Dijk G; Campfield L A; Smith F J; Burn P; Nelligan J A; Bell S M; Baskin D G; Woods S C; Schwartz M W
Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):664-8.
1996: Seeley R J; Matson C A; Chavez M; Woods S C; Dallman M F; Schwartz M W
Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding.
The American journal of physiology 1996;271(3 Pt 2):R819-23.
1996: Schwartz M W; Seeley R J; Campfield L A; Burn P; Baskin D G
Identification of targets of leptin action in rat hypothalamus.
The Journal of clinical investigation 1996;98(5):1101-6.
1996: Figlewicz D P; Schwartz M W; Seeley R J; Chavez M; Baskin D G; Woods S C; Porte D
Endocrine regulation of food intake and body weight.
The Journal of laboratory and clinical medicine 1996;127(4):328-32.
1996: Schwartz M W; Baskin D G; Bukowski T R; Kuijper J L; Foster D; Lasser G; Prunkard D E; Porte D; Woods S C; Seeley R J; Weigle D S
Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice.
Diabetes 1996;45(4):531-5.
1996: Baura G D; Foster D M; Kaiyala K; Porte D; Kahn S E; Schwartz M W
Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs.
Diabetes 1996;45(1):86-90.
1996: Woods S C; Chavez M; Park C R; Riedy C; Kaiyala K; Richardson R D; Figlewicz D P; Schwartz M W; Porte D; Seeley R J
The evaluation of insulin as a metabolic signal influencing behavior via the brain.
Neuroscience and biobehavioral reviews 1996;20(1):139-44.
1995: Baskin D G; Norwood B J; Schwartz M W; Koerker D J
Estradiol inhibits the increase of hypothalamic neuropeptide Y messenger ribonucleic acid expression induced by weight loss in ovariectomized rats.
Endocrinology 1995;136(12):5547-54.
1995: Schwartz M W; Dallman M F; Woods S C
Hypothalamic response to starvation: implications for the study of wasting disorders.
The American journal of physiology 1995;269(5 Pt 2):R949-57.
1995: Kaiyala K J; Woods S C; Schwartz M W
New model for the regulation of energy balance and adiposity by the central nervous system.
The American journal of clinical nutrition 1995;62(5 Suppl):1123S-1134S.
1995: Chavez M; Kaiyala K; Madden L J; Schwartz M W; Woods S C
Intraventricular insulin and the level of maintained body weight in rats.
Behavioral neuroscience 1995;109(3):528-31.
1995: Schwartz M W; Boyko E J; Kahn S E; Ravussin E; Bogardus C
Reduced insulin secretion: an independent predictor of body weight gain.
The Journal of clinical endocrinology and metabolism 1995;80(5):1571-6.
1995: Sipols A J; Baskin D G; Schwartz M W
Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression.
Diabetes 1995;44(2):147-51.
1994: Verchere C B; Kowalyk S; Shen G H; Brown M R; Schwartz M W; Baskin D G; Taborsky G J
Major species variation in the expression of galanin messenger ribonucleic acid in mammalian celiac ganglion.
Endocrinology 1994;135(3):1052-9.
1994: Kahn S E; Prigeon R L; McCulloch D K; Boyko E J; Bergman R N; Schwartz M W; Neifing J L; Ward W K; Beard J C; Palmer J P
The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects.
Diabetes 1994;43(4):587-92.
1994: Baskin D G; Schwartz M W; Sipols A J; D'Alessio D A; Goldstein B J; White M F
Insulin receptor substrate-1 (IRS-1) expression in rat brain.
Endocrinology 1994;134(4):1952-5.
1993: Kahn S E; Prigeon R L; McCulloch D K; Boyko E J; Bergman R N; Schwartz M W; Neifing J L; Ward W K; Beard J C; Palmer J P
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.
Diabetes 1993;42(11):1663-72.
1993: Baura G D; Foster D M; Porte D; Kahn S E; Bergman R N; Cobelli C; Schwartz M W
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.
The Journal of clinical investigation 1993;92(4):1824-30.
1993: Baskin D G; Sipols A J; Schwartz M W; White M F
Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine.
Regulatory peptides 1993;48(1-2):257-66.
1993: Schwartz M W; Figlewicz D P; Woods S C; Porte D; Baskin D G
Insulin, neuropeptide Y, and food intake.
Annals of the New York Academy of Sciences 1993;692():60-71.
1993: Baskin D G; Gierke E P; Wilcox B J; Matsumoto A M; Schwartz M W
Food intake and estradiol effects on insulin binding in brain and liver.
Physiology & behavior 1993;53(4):757-62.
1993: Israel P A; Park C R; Schwartz M W; Green P K; Sipols A J; Woods S C; Porte D; Figlewicz D P
Effect of diet-induced obesity and experimental hyperinsulinemia on insulin uptake into CSF of the rat.
Brain research bulletin 1993;30(5-6):571-5.
1993: Boswell T; Richardson R D; Schwartz M W; D'Alessio D A; Woods S C; Sipols A J; Baskin D G; Kenagy G J
NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding.
Brain research bulletin 1993;32(4):379-84.
1993: Schwartz M W; Sipols A J; Grubin C E; Baskin D G
Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase.
Brain research bulletin 1993;31(3-4):361-7.
1992: Schwartz M W; Figlewicz D P; Baskin D G; Woods S C; Porte D
Insulin in the brain: a hormonal regulator of energy balance.
Endocrine reviews 1992;13(3):387-414.
1992: Schwartz M W; Sipols A J; Marks J L; Sanacora G; White J D; Scheurink A; Kahn S E; Baskin D G; Woods S C; Figlewicz D P
Inhibition of hypothalamic neuropeptide Y gene expression by insulin.
Endocrinology 1992;130(6):3608-16.
1992: Kahn S E; Bergman R N; Schwartz M W; Taborsky G J; Porte D
Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans.
The American journal of physiology 1992;262(4 Pt 1):E518-23.
1992: Kahn S E; McCulloch D K; Schwartz M W; Palmer J P; Porte D
Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1992;74(1):192-7.
1991: Schwartz M W; Bergman R N; Kahn S E; Taborsky G J; Fisher L D; Sipols A J; Woods S C; Steil G M; Porte D
Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.
The Journal of clinical investigation 1991;88(4):1272-81.
1991: Schwartz M W; Marks J L; Sipols A J; Baskin D G; Woods S C; Kahn S E; Porte D
Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats.
Endocrinology 1991;128(5):2645-7.
1991: McCulloch D K; Kahn S E; Schwartz M W; Koerker D J; Palmer J P
Effect of nicotinic acid-induced insulin resistance on pancreatic B cell function in normal and streptozocin-treated baboons.
The Journal of clinical investigation 1991;87(4):1395-401.
1990: Kahn S E; Klaff L J; Schwartz M W; Beard J C; Bergman R N; Taborsky G J; Porte D
Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose.
The Journal of clinical endocrinology and metabolism 1990;71(4):994-1002.
1990: Schwartz M W; Sipols A; Kahn S E; Lattemann D F; Taborsky G J; Bergman R N; Woods S C; Porte D
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.
The American journal of physiology 1990;259(3 Pt 1):E378-83.
1990: Schwartz M W; Figlewicz D F; Kahn S E; Baskin D G; Greenwood M R; Porte D
Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats.
Peptides 1990;11(3):467-72.
1990: Saad M F; Kahn S E; Nelson R G; Pettitt D J; Knowler W C; Schwartz M W; Kowalyk S; Bennett P H; Porte D
Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1990;70(5):1247-53.
1990: Kahn S E; D'Alessio D A; Schwartz M W; Fujimoto W Y; Ensinck J W; Taborsky G J; Porte D
Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells.
Diabetes 1990;39(5):634-8.
1989: Kahn S E; Beard J C; Schwartz M W; Ward W K; Ding H L; Bergman R N; Taborsky G J; Porte D
Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance.
Diabetes 1989;38(5):562-8.

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