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Thue Schwartz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Holst Birgitte; Egerod Kristoffer L; Jin Chunyu; Petersen Pia Steen; Østergaard Mette Viberg; Hald Jacob; Sprinkel A M Ejernaes; Størling Joachim; Mandrup-Poulsen Thomas; Holst Jens J; Thams Peter; Orskov Cathrine; Wierup Nils; Sundler Frank; Madsen Ole D; Schwartz Thue W
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.
Nygaard Rie; Frimurer Thomas M; Holst Birgitte; Rosenkilde Mette M; Schwartz Thue W
Ligand binding and micro-switches in 7TM receptor structures.
Terpager Marie; Scholl D Jason; Kubale Valentina; Martini Lene; Elling Christian E; Schwartz Thue W
Construction of covalently coupled, concatameric dimers of 7TM receptors.

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All Publications

2009: Holst Birgitte; Egerod Kristoffer L; Jin Chunyu; Petersen Pia Steen; Østergaard Mette Viberg; Hald Jacob; Sprinkel A M Ejernaes; Størling Joachim; Mandrup-Poulsen Thomas; Holst Jens J; Thams Peter; Orskov Cathrine; Wierup Nils; Sundler Frank; Madsen Ole D; Schwartz Thue W
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.
Endocrinology 2009;150(6):2577-85.
2009: Nygaard Rie; Frimurer Thomas M; Holst Birgitte; Rosenkilde Mette M; Schwartz Thue W
Ligand binding and micro-switches in 7TM receptor structures.
Trends in pharmacological sciences 2009;30(5):249-59.
2009: Terpager Marie; Scholl D Jason; Kubale Valentina; Martini Lene; Elling Christian E; Schwartz Thue W
Construction of covalently coupled, concatameric dimers of 7TM receptors.
Journal of receptor and signal transduction research 2009;29(5):235-45.
2008: Engelstoft Maja S; Egerod Kristoffer L; Holst Birgitte; Schwartz Thue W
A gut feeling for obesity: 7TM sensors on enteroendocrine cells.
Cell metabolism 2008;8(6):447-9.
2008: Schwartz Thue W; Hubbell Wayne L
Structural biology: A moving story of receptors.
Nature 2008;455(7212):473-4.
2008: Storjohann Laura; Holst Birgitte; Schwartz Thue W
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39.
Biochemistry 2008;47(35):9198-207.
2008: Jensen Pia C; Thiele Stefanie; Ulven Trond; Schwartz Thue W; Rosenkilde Mette M
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding.
The Journal of biological chemistry 2008;283(34):23121-8.
2008: Storjohann Laura; Holst Birgitte; Schwartz Thue W
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
FEBS letters 2008;582(17):2583-8.
2008: Jorgensen Rasmus; Holliday Nicholas D; Hansen Jakob L; Vrecl Milka; Heding Anders; Schwartz Thue W; Elling Christian E
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer.
Molecular pharmacology 2008;73(2):349-58.
2007: Holliday Nicholas D; Holst Birgitte; Rodionova Elena A; Schwartz Thue W; Cox Helen M
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):3100-12.
2007: Rosenkilde Mette M; Gerlach Lars-Ole; Hatse Sigrid; Skerlj Renato T; Schols Dominique; Bridger Gary J; Schwartz Thue W
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.
The Journal of biological chemistry 2007;282(37):27354-65.
2007: Jensen Pia C; Nygaard Rie; Thiele Stefanie; Elder Amy; Zhu Guoming; Kolbeck Roland; Ghosh Shomir; Schwartz Thue W; Rosenkilde Mette M
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8.
Molecular pharmacology 2007;72(2):327-40.
2007: Schwartz Thue W; Holst Birgitte
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?
Trends in pharmacological sciences 2007;28(8):366-73.
2007: Egerod Kristoffer L; Holst Birgitte; Petersen Pia S; Hansen Jacob B; Mulder Jan; Hökfelt Tomas; Schwartz Thue W
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.
Molecular endocrinology (Baltimore, Md.) 2007;21(7):1685-98.
2007: Jorgensen Rasmus; Kubale Valentina; Vrecl Milka; Schwartz Thue W; Elling Christian E
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s).
The Journal of pharmacology and experimental therapeutics 2007;322(1):148-54.
2007: Lüttichau Hans R; Johnsen Anders H; Jurlander Jesper; Rosenkilde Mette M; Schwartz Thue W
Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3.
The Journal of biological chemistry 2007;282(24):17794-805.
2007: Holst Birgitte; Mokrosinski Jacek; Lang Manja; Brandt Erik; Nygaard Rie; Frimurer Thomas M; Beck-Sickinger Annette G; Schwartz Thue W
Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.
The Journal of biological chemistry 2007;282(21):15799-811.
2007: Hatse Sigrid; Huskens Dana; Princen Katrien; Vermeire Kurt; Bridger Gary J; De Clercq Erik; Rosenkilde Mette M; Schwartz Thue W; Schols Dominique
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor.
Journal of virology 2007;81(7):3632-9.
2007: Rosenkilde Mette M; Andersen Michael B; Nygaard Rie; Frimurer Thomas M; Schwartz Thue W
Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI.
Molecular pharmacology 2007;71(3):930-41.
2007: Holst Birgitte; Egerod Kristoffer L; Schild Enrico; Vickers Steve P; Cheetham Sharon; Gerlach Lars-Ole; Storjohann Laura; Stidsen Carsten E; Jones Rob; Beck-Sickinger Annette G; Schwartz Thue W
GPR39 signaling is stimulated by zinc ions but not by obestatin.
Endocrinology 2007;148(1):13-20.
2006: Rosenkilde Mette M; David Ralf; Oerlecke Ilka; Benned-Jensen Tau; Geumann Ulf; Beck-Sickinger Anette G; Schwartz Thue W
Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V.
Molecular pharmacology 2006;70(6):1892-901.
2006: Holst Birgitte; Lang Manja; Brandt Erik; Bach Anders; Howard Andrew; Frimurer Thomas M; Beck-Sickinger Annette; Schwartz Thue W
Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor.
Molecular pharmacology 2006;70(3):936-46.
2006: Nygaard Rie; Nielbo Steen; Schwartz Thue W; Poulsen Flemming M
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR.
Biochemistry 2006;45(27):8350-7.
2006: Elling Christian E; Frimurer Thomas M; Gerlach Lars-Ole; Jorgensen Rasmus; Holst Birgitte; Schwartz Thue W
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation.
The Journal of biological chemistry 2006;281(25):17337-46.
2006: Rosenkilde Mette M; Benned-Jensen Tau; Andersen Helene; Holst Peter J; Kledal Thomas N; Lüttichau Hans R; Larsen Jørgen K; Christensen Jan P; Schwartz Thue W
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.
The Journal of biological chemistry 2006;281(19):13199-208.
2006: Holst Birgitte; Schwartz Thue W
Ghrelin receptor mutations--too little height and too much hunger.
The Journal of clinical investigation 2006;116(3):637-41.
2006: Rosenkilde Mette M; Schwartz Thue W
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors.
Current topics in medicinal chemistry 2006;6(13):1319-33.
2006: Schwartz Thue W; Holst Birgitte
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors.
Journal of receptor and signal transduction research 2006;26(1-2):107-28.
2006: Schwartz Thue W; Frimurer Thomas M; Holst Birgitte; Rosenkilde Mette M; Elling Christian E
Molecular mechanism of 7TM receptor activation--a global toggle switch model.
Annual review of pharmacology and toxicology 2006;46():481-519.
2005: Hatse Sigrid; Princen Katrien; De Clercq Erik; Rosenkilde Mette M; Schwartz Thue W; Hernandez-Abad Pedro E; Skerlj Renato T; Bridger Gary J; Schols Dominique
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.
Biochemical pharmacology 2005;70(5):752-61.
2005: Holst Birgitte; Brandt Erik; Bach Anders; Heding Anders; Schwartz Thue W
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling.
Molecular endocrinology (Baltimore, Md.) 2005;19(9):2400-11.
2005: Rosenkilde Mette M; Kledal Thomas N; Schwartz Thue W
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3.
Molecular pharmacology 2005;68(1):11-9.
2005: Jensen Kristian K; Manfra Denise J; Grisotto Marcos G; Martin Andrea P; Vassileva Galya; Kelley Kevin; Schwartz Thue W; Lira Sergio A
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3686-94.
2005: Jorgensen Rasmus; Martini Lene; Schwartz Thue W; Elling Christian E
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype.
Molecular endocrinology (Baltimore, Md.) 2005;19(3):812-23.
2005: Casarosa Paola; Waldhoer Maria; LiWang Patricia J; Vischer Henry F; Kledal Thomas; Timmerman Henk; Schwartz Thue W; Smit Martine J; Leurs Rob
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor.
The Journal of biological chemistry 2005;280(5):3275-85.
2004: Princen Katrien; Hatse Sigrid; Vermeire Kurt; Aquaro Stefano; De Clercq Erik; Gerlach Lars-Ole; Rosenkilde Mette; Schwartz Thue W; Skerlj Renato; Bridger Gary; Schols Dominique
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist.
Journal of virology 2004;78(23):12996-3006.
2004: Heydorn Arne; Søndergaard Birgitte P; Ersbøll Bjarne; Holst Birgitte; Nielsen Finn Cilius; Haft Carol Renfrew; Whistler Jennifer; Schwartz Thue W
A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).
The Journal of biological chemistry 2004;279(52):54291-303.
2004: Holst Birgitte; Holliday Nicholas D; Bach Anders; Elling Christian E; Cox Helen M; Schwartz Thue W
Common structural basis for constitutive activity of the ghrelin receptor family.
The Journal of biological chemistry 2004;279(51):53806-17.
2004: McLean Katherine A; Holst Peter J; Martini Lene; Schwartz Thue W; Rosenkilde Mette M
Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74.
Virology 2004;325(2):241-51.
2004: Rosenkilde Mette M; Schwartz Thue W
The chemokine system -- a major regulator of angiogenesis in health and disease.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2004;112(7-8):481-95.
2004: Rosenkilde Mette M; McLean Katherine A; Holst Peter J; Schwartz Thue W
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins.
The Journal of biological chemistry 2004;279(31):32524-33.
2004: Holst Birgitte; Schwartz Thue W
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation.
Trends in pharmacological sciences 2004;25(3):113-7.
2004: Heydorn Arne; Søndergaard Birgitte P; Hadrup Niels; Holst Birgitte; Haft Carol Renfrew; Schwartz Thue W
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting.
FEBS letters 2004;556(1-3):276-80.
2004: Rosenkilde Mette M; Gerlach Lars-Ole; Jakobsen Janus S; Skerlj Renato T; Bridger Gary J; Schwartz Thue W
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor.
The Journal of biological chemistry 2004;279(4):3033-41.
2003: Holst Birgitte; Cygankiewicz Adam; Jensen Tine Halkjaer; Ankersen Michael; Schwartz Thue W
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist.
Molecular endocrinology (Baltimore, Md.) 2003;17(11):2201-10.
2003: Hatse Sigrid; Princen Katrien; Vermeire Kurt; Gerlach Lars-Ole; Rosenkilde Mette M; Schwartz Thue W; Bridger Gary; De Clercq Erik; Schols Dominique
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
FEBS letters 2003;546(2-3):300-6.
2003: Lindow Morten; Nansen Anneline; Bartholdy Christina; Stryhn Annette; Hansen Nils J V; Boesen Thomas P; Wells Timothy N C; Schwartz Thue W; Thomsen Allan R
The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation.
Journal of virology 2003;77(13):7393-400.
2003: Holst Birgitte; Schwartz Thue W
Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe.
Annals of the New York Academy of Sciences 2003;994():1-11.
2003: Waldhoer Maria; Casarosa Paola; Rosenkilde Mette M; Smit Martine J; Leurs Rob; Whistler Jennifer L; Schwartz Thue W
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis.
The Journal of biological chemistry 2003;278(21):19473-82.
2003: Lindow Morten; Lüttichau Hans Rudolf; Schwartz Thue W
Viral leads for chemokine-modulatory drugs.
Trends in pharmacological sciences 2003;24(3):126-30.
2003: Lüttichau Hans R; Clark-Lewis Ian; Jensen Peter Ø; Moser Claus; Gerstoft Jan; Schwartz Thue W
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
The Journal of biological chemistry 2003;278(13):10928-33.
2003: Gerlach Lars Ole; Jakobsen Janus S; Jensen Kasper P; Rosenkilde Mette R; Skerlj Renato T; Ryde Ulf; Bridger Gary J; Schwartz Thue W
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor.
Biochemistry 2003;42(3):710-7.
2003: Holst Peter J; Lüttichau Hans R; Schwartz Thue W; Rosenkilde Mette M
Virally encoded chemokines and chemokine receptors in the role of viral infections.
Contributions to microbiology 2003;10():232-52.
2002: Holst Birgitte; Elling Christian E; Schwartz Thue W
Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.
The Journal of biological chemistry 2002;277(49):47662-70.
2002: Boesen Thomas P; Soni Bobby; Schwartz Thue W; Halkier Torben
Single-chain vascular endothelial growth factor variant with antagonist activity.
The Journal of biological chemistry 2002;277(43):40335-41.
2002: Waldhoer Maria; Kledal Thomas N; Farrell Helen; Schwartz Thue W
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities.
Journal of virology 2002;76(16):8161-8.
2002: Martini Lene; Hastrup Hanne; Holst Birgitte; Fraile-Ramos Alberto; Marsh Mark; Schwartz Thue W
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype.
Molecular pharmacology 2002;62(1):30-7.
2002: Costa-Neto Claudio M; Miyakawa Ayumi A; Pesquero João B; Oliveira Laerte; Hjorth Siv A; Schwartz Thue W; Paiva Antonio C M
Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants.
Canadian journal of physiology and pharmacology 2002;80(5):413-7.
2002: Fraile-Ramos Alberto; Pelchen-Matthews Annegret; Kledal Thomas N; Browne Helena; Schwartz Thue W; Marsh Mark
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes.
Traffic (Copenhagen, Denmark) 2002;3(3):218-32.
2002: Heding A; Elling C E; Schwartz T W
Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor.
Journal of receptor and signal transduction research 2002;22(1-4):241-52.
2001: Holst P J; Rosenkilde M M; Manfra D; Chen S C; Wiekowski M T; Holst B; Cifire F; Lipp M; Schwartz T W; Lira S A
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
The Journal of clinical investigation 2001;108(12):1789-96.
2001: Mizoue L S; Sullivan S K; King D S; Kledal T N; Schwartz T W; Bacon K B; Handel T M
Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine.
The Journal of biological chemistry 2001;276(36):33906-14.
2001: Lüttichau H R; Gerstoft J; Schwartz T W
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8.
Journal of leukocyte biology 2001;70(2):277-82.
2001: Hatse S; Princen K; Gerlach L O; Bridger G; Henson G; De Clercq E; Schwartz T W; Schols D
Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.
Molecular pharmacology 2001;60(1):164-73.
2001: Fraile-Ramos A; Kledal T N; Pelchen-Matthews A; Bowers K; Schwartz T W; Marsh M
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling.
Molecular biology of the cell 2001;12(6):1737-49.
2001: Holst B; Hastrup H; Raffetseder U; Martini L; Schwartz T W
Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis.
The Journal of biological chemistry 2001;276(23):19793-9.
2001: Lüttichau H R; Lewis I C; Gerstoft J; Schwartz T W
The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor.
European journal of immunology 2001;31(4):1217-20.
2001: Gerlach L O; Skerlj R T; Bridger G J; Schwartz T W
Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor.
The Journal of biological chemistry 2001;276(17):14153-60.
2001: Rosenkilde M M; Waldhoer M; Lüttichau H R; Schwartz T W
Virally encoded 7TM receptors.
Oncogene 2001;20(13):1582-93.
2001: Jensen K K; Martini L; Schwartz T W
Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering.
Biochemistry 2001;40(4):938-45.
2000: Holst B; Elling C E; Schwartz T W
Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor.
Molecular pharmacology 2000;58(2):263-70.
2000: Rosenkilde M M; Kledal T N; Holst P J; Schwartz T W
Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.
The Journal of biological chemistry 2000;275(34):26309-15.
2000: Costa-Neto C M; Miyakawa A A; Oliveira L; Hjorth S A; Schwartz T W; Paiva A C
Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor.
British journal of pharmacology 2000;130(6):1263-8.
2000: Rosenkilde M M; Schwartz T W
Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor.
Molecular pharmacology 2000;57(3):602-9.
2000: Elling C E; Raffetseder U; Nielsen S M; Schwartz T W
Disulfide bridge engineering in the tachykinin NK1 receptor.
Biochemistry 2000;39(4):667-75.
2000: Lüttichau H R; Stine J; Boesen T P; Johnsen A H; Chantry D; Gerstoft J; Schwartz T W
A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum.
The Journal of experimental medicine 2000;191(1):171-80.
1999: Elling C E; Thirstrup K; Holst B; Schwartz T W
Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12322-7.
1999: Klasse P J; Rosenkilde M M; Signoret N; Pelchen-Matthews A; Schwartz T W; Marsh M
CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection.
Journal of virology 1999;73(9):7453-66.
1999: Rosenkilde M M; Kledal T N; Bräuner-Osborne H; Schwartz T W
Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74.
The Journal of biological chemistry 1999;274(2):956-61.
1998: Kledal T N; Rosenkilde M M; Schwartz T W
Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28.
FEBS letters 1998;441(2):209-14.
1998: Schwartz T W; IJzerman A P
Principles of agonism: undressing efficacy.
Trends in pharmacological sciences 1998;19(11):433-6.
1998: Rosenkilde M M; Lucibello M; Holst B; Schwartz T W
Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor.
FEBS letters 1998;439(1-2):35-40.
1998: Signoret N; Rosenkilde M M; Klasse P J; Schwartz T W; Malim M H; Hoxie J A; Marsh M
Differential regulation of CXCR4 and CCR5 endocytosis.
Journal of cell science 1998;111 ( Pt 18)():2819-30.
1998: Nielsen S M; Elling C E; Schwartz T W
Split-receptors in the tachykinin neurokinin-1 system--mutational analysis of intracellular loop 3.
European journal of biochemistry / FEBS 1998;251(1-2):217-26.
1998: Holst B; Zoffmann S; Elling C E; Hjorth S A; Schwartz T W
Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor.
Molecular pharmacology 1998;53(1):166-75.
1998: Hjorth S A; Orskov C; Schwartz T W
Constitutive activity of glucagon receptor mutants.
Molecular endocrinology (Baltimore, Md.) 1998;12(1):78-86.
1997: Wells T N; Schwartz T W
Plagiarism of the host immune system: lessons about chemokine immunology from viruses.
Current opinion in biotechnology 1997;8(6):741-8.
1997: Signoret N; Oldridge J; Pelchen-Matthews A; Klasse P J; Tran T; Brass L F; Rosenkilde M M; Schwartz T W; Holmes W; Dallas W; Luther M A; Wells T N; Hoxie J A; Marsh M
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.
The Journal of cell biology 1997;139(3):651-64.
1997: Kledal T N; Rosenkilde M M; Coulin F; Simmons G; Johnsen A H; Alouani S; Power C A; Lüttichau H R; Gerstoft J; Clapham P R; Clark-Lewis I; Wells T N; Schwartz T W
A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.
Science (New York, N.Y.) 1997;277(5332):1656-9.
1997: Turcatti G; Zoffmann S; Lowe J A; Drozda S E; Chassaing G; Schwartz T W; Chollet A
Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands.
The Journal of biological chemistry 1997;272(34):21167-75.
1997: Schwartz T W; Perlman S; Rosenkilde M M; Hjorth S A
How receptor mutagenesis may confirm or confuse receptor classification.
Annals of the New York Academy of Sciences 1997;812():71-84.
1997: Elling C E; Thirstrup K; Nielsen S M; Hjorth S A; Schwartz T W
Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors.
Annals of the New York Academy of Sciences 1997;814():142-51.
1997: Perlman S; Costa-Neto C M; Miyakawa A A; Schambye H T; Hjorth S A; Paiva A C; Rivero R A; Greenlee W J; Schwartz T W
Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: susceptibility to receptor mutations.
Molecular pharmacology 1997;51(2):301-11.
1997: Schwartz T W
[7TM receptors--from the olfactory system and new hormones against HIV infection]
Ugeskrift for laeger 1997;159(9):1239-45.
1997: Elling C E; Thirstrup K; Nielsen S M; Hjorth S A; Schwartz T W
Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors.
Folding & design 1997;2(4):S76-80.
1996: Hastrup H; Schwartz T W
Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis.
FEBS letters 1996;399(3):264-6.
1996: Hjorth S A; Thirstrup K; Schwartz T W
Radioligand-dependent discrepancy in agonist affinities enhanced by mutations in the kappa-opioid receptor.
Molecular pharmacology 1996;50(4):977-84.
1996: Hjorth S A; Schwartz T W
Glucagon and GLP-1 receptors: lessons from chimeric ligands and receptors.
Acta physiologica Scandinavica 1996;157(3):343-5.
1996: Schwartz T W; Rosenkilde M M
Is there a 'lock' for all agonist 'keys' in 7TM receptors?
Trends in pharmacological sciences 1996;17(6):213-6.
1996: Thirstrup K; Elling C E; Hjorth S A; Schwartz T W
Construction of a high affinity zinc switch in the kappa-opioid receptor.
The Journal of biological chemistry 1996;271(14):7875-8.
1996: O'Hare M M; Schwartz T W
Biosynthesis of neuropeptide Y in porcine tissues and generation of N-terminal fragments in neuroblastoma cell lines.
Peptides 1996;17(1):147-53.
1995: Hjorth S A; Thirstrup K; Grandy D K; Schwartz T W
Analysis of selective binding epitopes for the kappa-opioid receptor antagonist nor-binaltorphimine.
Molecular pharmacology 1995;47(6):1089-94.
1995: Schambye H T; Hjorth S A; Weinstock J; Schwartz T W
Interaction between the nonpeptide angiotensin antagonist SKF-108,566 and histidine 256 (HisVI:16) of the angiotensin type 1 receptor.
Molecular pharmacology 1995;47(3):425-31.
1995: Elling C E; Nielsen S M; Schwartz T W
Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.
Nature 1995;374(6517):74-7.
1995: Gether U; Lowe J A; Schwartz T W
Tachykinin non-peptide antagonists: binding domain and molecular mode of action.
Biochemical Society transactions 1995;23(1):96-102.
1995: Perlman S; Schambye H T; Rivero R A; Greenlee W J; Hjorth S A; Schwartz T W
Non-peptide angiotensin agonist. Functional and molecular interaction with the AT1 receptor.
The Journal of biological chemistry 1995;270(4):1493-6.
1994: Hjorth S A; Schambye H T; Greenlee W J; Schwartz T W
Identification of peptide binding residues in the extracellular domains of the AT1 receptor.
The Journal of biological chemistry 1994;269(49):30953-9.
1994: Hjorth S A; Adelhorst K; Pedersen B B; Kirk O; Schwartz T W
Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes.
The Journal of biological chemistry 1994;269(48):30121-4.
1994: Rosenkilde M M; Cahir M; Gether U; Hjorth S A; Schwartz T W
Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.
The Journal of biological chemistry 1994;269(45):28160-4.
1994: Schambye H T; von Wijk B; Hjorth S A; Wienen W; Entzeroth M; Bergsma D J; Schwartz T W
Mutations in transmembrane segment VII of the AT1 receptor differentiate between closely related insurmountable and competitive angiotensin antagonists.
British journal of pharmacology 1994;113(2):331-3.
1994: Gether U; Nilsson L; Lowe J A; Schwartz T W
Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]
The Journal of biological chemistry 1994;269(39):23959-64.
1994: Schambye H T; Hjorth S A; Bergsma D J; Sathe G; Schwartz T W
Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7046-50.
1994: Gether U; Emonds-Alt X; Brelière J C; Fujii T; Hagiwara D; Pradier L; Garret C; Johansen T E; Schwartz T W
Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.
Molecular pharmacology 1994;45(3):500-8.
1994: Jensen C J; Gerard N P; Schwartz T W; Gether U
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
Molecular pharmacology 1994;45(2):294-9.
1993: Zoffmann S; Gether U; Schwartz T W
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
FEBS letters 1993;336(3):506-10.
1993: Schambye H T; Hjorth S A; Schwartz T W
[Non-peptide antagonists to angiotensin II receptors. A review]
Ugeskrift for laeger 1993;155(44):3558-62.
1993: Gether U; Johansen T E; Snider R M; Lowe J A; Emonds-Alt X; Yokota Y; Nakanishi S; Schwartz T W
Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor.
Regulatory peptides 1993;46(1-2):49-58.
1993: Gether U; Yokota Y; Emonds-Alt X; Brelière J C; Lowe J A; Snider R M; Nakanishi S; Schwartz T W
Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6194-8.
1993: Wulff B S; Johansen T E; Dalbøge H; O'Hare M M; Schwartz T W
Processing of two homologous precursors, pro-neuropeptide Y and pro-pancreatic polypeptide, in transfected cell lines expressing different precursor convertases.
The Journal of biological chemistry 1993;268(18):13327-35.
1993: Gether U; Johansen T E; Schwartz T W
Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.
The Journal of biological chemistry 1993;268(11):7893-8.
1993: Gether U; Johansen T E; Snider R M; Lowe J A; Nakanishi S; Schwartz T W
Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.
Nature 1993;362(6418):345-8.
1993: Wulff B S; Catipovic B; Okamoto H; Gether U; Schwartz T W; Johansen T E
Efficient amidation of C-peptide deleted NPY precursors by non-endocrine cells is affected by the presence of Lys-Arg at the C-terminus.
Molecular and cellular endocrinology 1993;91(1-2):135-41.
1992: Gether U; Marray T; Schwartz T W; Johansen T E
Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells.
FEBS letters 1992;296(3):241-4.
1991: Johansen T E; Schifter S; Vogel C K; Tolstoy S; Schwartz T W
Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors.
Molecular and cellular endocrinology 1991;82(1):51-60.
1991: Gether U; Aakerlund L; Schwartz T W
Comparison of peptidyl-glycine alpha-amidation activity in medullary thyroid carcinoma cells, pheochromocytomas, and serum.
Molecular and cellular endocrinology 1991;79(1-3):53-63.
1991: Johansen T E; O'Hare M M; Wulff B S; Schwartz T W
CHO cells synthesize amidated neuropeptide Y from a C-peptide deleted form of the precursor.
Endocrinology 1991;129(1):553-5.
1990: Jørgensen J C; Fuhlendorff J; Schwartz T W
Structure-function studies on neuropeptide Y and pancreatic polypeptide--evidence for two PP-fold receptors in vas deferens.
European journal of pharmacology 1990;186(1):105-14.
1990: Johansen T E; Schøller M S; Tolstoy S; Schwartz T W
Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectors.
FEBS letters 1990;267(2):289-94.
1990: Fuhlendorff J; Johansen N L; Melberg S G; Thøgersen H; Schwartz T W
The antiparallel pancreatic polypeptide fold in the binding of neuropeptide Y to Y1 and Y2 receptors.
The Journal of biological chemistry 1990;265(20):11706-12.
1990: Vangsted A J; Schwartz T W
Production of gastrin-releasing peptide-(18-27) and a stable fragment of its precursor in small cell lung carcinoma cells.
The Journal of clinical endocrinology and metabolism 1990;70(6):1586-93.
1990: Wulff B S; O'Hare M M; Boel E; Theill L E; Schwartz T W
Partial processing of the neuropeptide Y precursor in transfected CHO cells.
FEBS letters 1990;261(1):101-5.
1990: Aakerlund L; Gether U; Fuhlendorff J; Schwartz T W; Thastrup O
Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase.
FEBS letters 1990;260(1):73-8.
1990: Fuhlendorff J; Gether U; Aakerlund L; Langeland-Johansen N; Thøgersen H; Melberg S G; Olsen U B; Thastrup O; Schwartz T W
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):182-6.
1990: Schwartz T W; Fuhlendorff J; Kjems L L; Kristensen M S; Vervelde M; O'Hare M; Krstenansky J L; Bjørnholm B
Signal epitopes in the three-dimensional structure of neuropeptide Y. Interaction with Y1, Y2, and pancreatic polypeptide receptors.
Annals of the New York Academy of Sciences 1990;611():35-47.
1989: Sheikh S P; Holst J J; Orskov C; Ekman R; Schwartz T W
Release of PYY from pig intestinal mucosa; luminal and neural regulation.
Regulatory peptides 1989;26(3):253-66.
1989: O'Hare M M; Schwartz T W
Expression and precursor processing of neuropeptide Y in human and murine neuroblastoma and pheochromocytoma cell lines.
Cancer research 1989;49(24 Pt 1):7015-9.
1989: O'Hare M M; Schwartz T W
Expression and precursor processing of neuropeptide Y in human pheochromocytoma and neuroblastoma tumors.
Cancer research 1989;49(24 Pt 1):7010-4.
1989: Sheikh S P; Sheikh M I; Schwartz T W
Y2-type receptors for peptide YY on renal proximal tubular cells in the rabbit.
The American journal of physiology 1989;257(6 Pt 2):F978-84.
1989: Holst J J; Hansen M; Bork E; Schwartz T W
Elevated plasma concentrations of C-flanking gastrin-releasing peptide in small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(12):1831-8.
1989: Jørgensen J C; Sheikh S P; Forman A; Nørgård M; Schwartz T W; Ottesen B
Neuropeptide Y in the human female genital tract: localization and biological action.
The American journal of physiology 1989;257(2 Pt 1):E220-7.
1989: Busch-Sørensen M; Sheikh S P; O'Hare M; Tortora O; Schwartz T W; Gammeltoft S
Regional distribution of neuropeptide Y and its receptor in the porcine central nervous system.
Journal of neurochemistry 1989;52(5):1545-52.
1989: Sheikh S P; O'Hare M M; Tortora O; Schwartz T W
Binding of monoiodinated neuropeptide Y to hippocampal membranes and human neuroblastoma cell lines.
The Journal of biological chemistry 1989;264(12):6648-54.
1989: Sheikh S P; Håkanson R; Schwartz T W
Y1 and Y2 receptors for neuropeptide Y.
FEBS letters 1989;245(1-2):209-14.
1988: Schwartz T W
Effect of amino acid analogs on the processing of the pancreatic polypeptide precursor in primary cell cultures.
The Journal of biological chemistry 1988;263(23):11504-10.
1988: Gether U; Nielsen H V; Schwartz T W
Tyrosylation and purification of peptides for radioiodination.
Journal of chromatography 1988;447(2):341-9.
1988: Sheikh S P; Holst J J; Skak-Nielsen T; Knigge U; Warberg J; Theodorsson-Norheim E; Hökfelt T; Lundberg J M; Schwartz T W
Release of NPY in pig pancreas: dual parasympathetic and sympathetic regulation.
The American journal of physiology 1988;255(1 Pt 1):G46-54.
1988: O'Hare M M; Tenmoku S; Aakerlund L; Hilsted L; Johnsen A; Schwartz T W
Neuropeptide Y in guinea pig, rabbit, rat and man. Identical amino acid sequence and oxidation of methionine-17.
Regulatory peptides 1988;20(4):293-304.
1988: Tenmoku S; Ottesen B; O'Hare M M; Sheikh S; Bardrum B; Hansen B; Walker B; Murphy R F; Schwartz T W
Interaction of NPY and VIP in regulation of myometrial blood flow and mechanical activity.
Peptides 1988;9(2):269-75.
1987: Schwartz T W; Sheikh S P; O'Hare M M
Receptors on phaeochromocytoma cells for two members of the PP-fold family--NPY and PP.
FEBS letters 1987;225(1-2):209-14.
1987: Schwartz T W; Hansen H F; Gether U; Aakerlund L
Processing or inactivation of antimicrobial peptides.
Nature 1987;329(6139):494.
1987: O'Hare M M; Tortora O; Gether U; Nielsen H V; Schwartz T W
High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.
Journal of chromatography 1987;389(2):379-88.
1986: Nielsen H V; Gether U; Schwartz T W
Cat pancreatic eicosapeptide and its biosynthetic intermediate. Conservation of a monobasic processing site.
The Biochemical journal 1986;240(1):69-74.

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