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Pamela Schwartzberg

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Jennifer L Cannons; Kristina T Lu; Pamela L Schwartzberg
T follicular helper cell diversity and plasticity.
Mala Dutta; Julio Gomez-Rodriguez; Sun-Hee Hwang; Zachary J Kraus; Sang-Yun Lee; Jennifer L Cannons; Jun Cheng; Edward K Wakeland; David L Wiest; Pamela L Schwartzberg
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.
Jennifer L Cannons; Kristina T Lu; Pamela L Schwartzberg
Lymph node choreography: B cells take the lead.

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All Publications

2013: Jennifer L Cannons; Kristina T Lu; Pamela L Schwartzberg
T follicular helper cell diversity and plasticity.
Trends in immunology 2013;34(5):200-7.
2013: Mala Dutta; Julio Gomez-Rodriguez; Sun-Hee Hwang; Zachary J Kraus; Sang-Yun Lee; Jennifer L Cannons; Jun Cheng; Edward K Wakeland; David L Wiest; Pamela L Schwartzberg
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2121-8.
2012: Jennifer L Cannons; Kristina T Lu; Pamela L Schwartzberg
Lymph node choreography: B cells take the lead.
Nature immunology 2012;13(7):630-2.
2012: Fang Zhao; Jennifer L Cannons; Mala Dutta; Gillian M Griffiths; Pamela L Schwartzberg
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Immunity 2012;36(6):1003-16.
2011: Kristina T Lu; John J O'Shea; Hongwei Sun; Lai Wei; Stacie M Anderson; Paul Bible; Jennifer L Cannons; Abdel G Elkahloun; Robin Handon; Yuka Kanno; Pamela L Schwartzberg
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.
Immunity 2011;35(4):622-32.
2011: Julio Gomez-Rodriguez; Zachary J Kraus; Pamela L Schwartzberg
Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.
The FEBS journal 2011;278(12):1980-9.
2011: Ronald N Germain; Pamela L Schwartzberg
The human condition: an immunological perspective.
Nature immunology 2011;12(5):369-72.
2011: Shuling Zhang; Julie A Readinger; Wendy DuBois; Mirkka Janka-Junttila; Richard Robinson; Margaret Pruitt; Val Bliskovsky; Julie Z Wu; Kaori Sakakibara; Jyoti Patel; Carole A Parent; Lino Tessarollo; Pamela L Schwartzberg; Beverly A Mock
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.
Blood 2011;117(4):1228-38.
2011: Jennifer L Cannons; Stuart G Tangye; Pamela L Schwartzberg
SLAM family receptors and SAP adaptors in immunity.
Annual review of immunology 2011;29():665-705.
2010: Aida M Andrés; Megan Y Dennis; Warren W Kretzschmar; Jennifer L Cannons; Shih-Queen Lee-Lin; Belen Hurle; Pamela L Schwartzberg; Scott H Williamson; Carlos D Bustamante; Rasmus Nielsen; Andrew G Clark; Eric Green
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.
PLoS genetics 2010;6(10):e1001157.
2010: Jennifer L Cannons; Julie Z Wu; Julio Gomez-Rodriguez; Jinyi Zhang; Baoxia Dong; Yin Liu; Stephen Shaw; Katherine A Siminovitch; Pamela L Schwartzberg
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2819-27.
2010: Jennifer L Cannons; Hai Qi; Kristina T Lu; Mala Dutta; Julio Gomez-Rodriguez; Jun Cheng; Edward K Wakeland; Ronald N Germain; Pamela L Schwartzberg
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.
Immunity 2010;32(2):253-65.
2009: Julio Gomez-Rodriguez; Nisebita Sahu; Robin Handon; Todd S Davidson; Stacie M Anderson; Martha R Kirby; Avery August; Pamela L Schwartzberg
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Immunity 2009;31(4):587-97.
2009: Svenja Steinfelder; John F Andersen; Jennifer L Cannons; Carl G Feng; Manju Joshi; Dennis Dwyer; Patricia Caspar; Pamela L Schwartzberg; Alan Sher; Dragana Jankovic
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).
The Journal of experimental medicine 2009;206(8):1681-90.
2009: Julie A Readinger; Kristen L Mueller; Ana M Venegas; Reiko Horai; Pamela L Schwartzberg
Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.
Immunological reviews 2009;228(1):93-114.
2009: Y Jeffrey Chiang; Martha S Jordan; Reiko Horai; Pamela L Schwartzberg; Gary A Koretzky; Richard J Hodes
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
The Journal of biological chemistry 2009;284(7):4429-38.
2008: Carl G Feng; Lixin Zheng; Dragana Jankovic; Andre Bafica; Jennifer L Cannons; Wendy T Watford; Damien Chaussabel; Sara Hieny; Patricia Caspar; Pamela L Schwartzberg; Michael J Lenardo; Alan Sher
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.
Nature immunology 2008;9(11):1279-87.
2008: Hai Qi; Jennifer L Cannons; Frederick Klauschen; Pamela L Schwartzberg; Ronald N Germain
SAP-controlled T-B cell interactions underlie germinal centre formation.
Nature 2008;455(7214):764-9.
2008: Julio Gómez-Rodríguez; Valance Washington; Jun Cheng; Amalia Dutra; Evgenia Pak; Pentao Liu; Daniel W McVicar; Pamela L Schwartzberg
Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs.
Nucleic acids research 2008;36(18):e117.
2008: Julie A Readinger; Gillian M Schiralli; Jian-Kang Jiang; Craig J Thomas; Avery August; Andrew J Henderson; Pamela L Schwartzberg
Selective targeting of ITK blocks multiple steps of HIV replication.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6684-9.
2007: Reiko Horai; Kristen L Mueller; Robin A Handon; Jennifer L Cannons; Stacie M Anderson; Martha R Kirby; Pamela L Schwartzberg
Requirements for selection of conventional and innate T lymphocyte lineages.
Immunity 2007;27(5):775-85.
2007: Julio Gomez-Rodriguez; Julie A Readinger; Irene C Viorritto; Kristen L Mueller; Richard A Houghtling; Pamela L Schwartzberg
Tec kinases, actin, and cell adhesion.
Immunological reviews 2007;218():45-64.
2007: Marsilio Adriani; Joseph Aoki; Reiko Horai; Angela M Thornton; Akihiro Konno; Martha Kirby; Stacie M Anderson; Richard Siegel; Fabio Candotti; Pamela L Schwartzberg
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.
Clinical immunology (Orlando, Fla.) 2007;124(1):41-8.
2007: Ling Zhao; Jennifer L Cannons; Stacie Anderson; Martha Kirby; Liping Xu; Lucio H Castilla; Pamela L Schwartzberg; Rémy Bosselut; P Paul Liu
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus.
Blood 2007;109(8):3432-40.
2007: Pamela L Schwartzberg
Formin the way.
Immunity 2007;26(2):139-41.
2007: Akihiro Konno; Martha Kirby; Stacie A Anderson; Pamela L Schwartzberg; Fabio Candotti
The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP).
International immunology 2007;19(2):185-92.
2006: Marjorie J Lindhurst; Giuseppe Fiermonte; Shiwei Song; Eduard Struys; Francesco De Leonardis; Pamela L Schwartzberg; Amy Chen; Alessandra Castegna; Nanda Verhoeven; Christopher K Mathews; Ferdinando Palmieri; Leslie G Biesecker
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15927-32.
2006: Christine Broussard; Christine Fleischacker; Christine Fleischecker; Reiko Horai; Madeva Chetana; Ana M Venegas; Leslie L Sharp; Stephen M Hedrick; BJ Fowlkes; Pamela L Schwartzberg
Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.
Immunity 2006;25(1):93-104.
2006: Jennifer L Cannons; Li J Yu; Dragana Jankovic; Shane Crotty; Reiko Horai; Martha Kirby; Stacie Anderson; Allen W Cheever; Alan Sher; Pamela L Schwartzberg
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.
The Journal of experimental medicine 2006;203(6):1551-65.
2006: Ning Gao; Pamela L Schwartzberg; Julie A Wilder; Bruce R Blazar; Dorothy Yuan
B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2758-64.
2006: Martha S Jordan; Jeffrey Sadler; Jessica E Austin; Lisa D Finkelstein; ANDREW SINGER; Pamela L Schwartzberg; Gary A Koretzky
Functional hierarchy of the N-terminal tyrosines of SLP-76.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2430-8.
2005: Lisa D Finkelstein; Yoji Shimizu; Pamela L Schwartzberg
Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5923-30.
2005: Stacie K Loftus; Jennifer L Cannons; Arturo Incao; Evgenia Pak; Amy Chen; Patricia M Zerfas; Mark A Bryant; Leslie G Biesecker; Pamela L Schwartzberg; William J Pavan
Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency.
PLoS genetics 2005;1(3):e38.
2005: Pamela L Schwartzberg; Lisa D Finkelstein; Julie A Readinger
TEC-family kinases: regulators of T-helper-cell differentiation.
Nature reviews. Immunology 2005;5(4):284-95.
2005: Kim E Nichols; Jamie Hom; Shun-You Gong; Arupa Ganguly; Cindy S Ma; Jennifer L Cannons; Stuart G Tangye; Pamela L Schwartzberg; Gary A Koretzky; Paul L Stein
Regulation of NKT cell development by SAP, the protein defective in XLP.
Nature medicine 2005;11(3):340-5.
2005: Derek Dombroski; Richard A Houghtling; Christine M Labno; Patricia Precht; Aya Takesono; Natasha J Caplen; Daniel D Billadeau; Ronald L Wange; Janis Burkhardt; Pamela L Schwartzberg
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1385-92.
2005: Kim E Nichols; Cindy S Ma; Jennifer L Cannons; Pamela L Schwartzberg; Stuart G Tangye
Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.
Immunological reviews 2005;203():180-99.
2005: Leslie J Berg; Lisa D Finkelstein; Julie Lucas; Pamela L Schwartzberg
Tec family kinases in T lymphocyte development and function.
Annual review of immunology 2005;23():549-600.
2004: Reiko Horai; Akiko Nakajima; Katsuyoshi Habiro; Motoko Kotani; Susumu Nakae; Taizo Matsuki; Aya Nambu; Shinobu Saijo; Hayato Kotaki; Katsuko Sudo; Akihiko Okahara; Hidetoshi Tanioka; Toshimi Ikuse; Naoto Ishii; Pamela L Schwartzberg; Ryo Abe; Yoichiro Iwakura
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
The Journal of clinical investigation 2004;114(11):1603-11.
2004: Jennifer L Cannons; Li J Yu; Brenna Hill; Lilia Mijares; Derek Dombroski; Kim E Nichols; Anthony Antonellis; Gary A Koretzky; Kevin Gardner; Pamela L Schwartzberg
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.
Immunity 2004;21(5):693-706.
2004: Jill M Mooney; Jennifer Klem; Christoph Wülfing; Lilia Mijares; Pamela L Schwartzberg; Michael Bennett; John Schatzle
The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3953-61.
2004: Lisa D Finkelstein; Pamela L Schwartzberg
Tec kinases: shaping T-cell activation through actin.
Trends in cell biology 2004;14(8):443-51.
2004: Jun Cheng; Amalia Dutra; Aya Takesono; Lisa Garrett-Beal; Pamela L Schwartzberg
Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media.
Genesis (New York, N.Y. : 2000) 2004;39(2):100-4.
2004: Jennifer L Cannons; Pamela L Schwartzberg
Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases?
Current opinion in immunology 2004;16(3):296-303.
2004: Aya Takesono; Reiko Horai; Michiko Mandai; Derek Dombroski; Pamela L Schwartzberg
Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac.
Current biology : CB 2004;14(10):917-22.
2004: Raman Sood; P I Bader; M C Speer; Yvonne H Edwards; Erica M Eddings; R T Blair; Ping Hu; Mezbah U Faruque; Christiane M Robbins; H Zhang; J Leuders; K Morrison; D Thompson; Pamela L Schwartzberg; Paul S Meltzer; Jeffrey M. Trent
Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis.
Cytogenetic and genome research 2004;106(1):61-7.
2003: Pamela L Schwartzberg
Amplifying Btk's signal.
Immunity 2003;19(5):634-6.
2003: Christine M Labno; Carol M Lewis; Daoqi You; Daisy W Leung; Aya Takesono; Natalie Kamberos; Abhinav Seth; Lisa D Finkelstein; Michael K Rosen; Pamela L Schwartzberg; Janis Burkhardt
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.
Current biology : CB 2003;13(18):1619-24.
2003: Shane Crotty; Ellen N Kersh; Jennifer L Cannons; Pamela L Schwartzberg; Rafi Ahmed
SAP is required for generating long-term humoral immunity.
Nature 2003;421(6920):282-7.
2003: Pamela L Schwartzberg
Genetic approaches to tyrosine kinase signaling pathways in the immune system.
Immunologic research 2003;27(2-3):481-8.
2002: Aya Takesono; Lisa D Finkelstein; Pamela L Schwartzberg
Beyond calcium: new signaling pathways for Tec family kinases.
Journal of cell science 2002;115(Pt 15):3039-48.
2002: Andrew P Makrigiannis; Amanda T Pau; Pamela L Schwartzberg; Daniel W McVicar; Thomas W Beck; Stephen K Anderson
A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice.
Genomics 2002;79(3):437-44.
2001: EM Schaeffer; George S Yap; CM Lewis; Michael J Czar; Daniel W McVicar; Allen W Cheever; Alan Sher; Pamela L Schwartzberg
Mutation of Tec family kinases alters T helper cell differentiation.
Nature immunology 2001;2(12):1183-8.
2001: Michael J Czar; Jayanta Debnath; EM Schaeffer; CM Lewis; Pamela L Schwartzberg
Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.
Biochemical Society transactions 2001;29(Pt 6):863-7.
2001: Pamela L Schwartzberg
Immunology. Tampering with the immune system.
Science (New York, N.Y.) 2001;293(5528):228-9.
2001: Michael J Czar; Pamela L Schwartzberg
XLP: one gene, many players.
Clinical immunology (Orlando, Fla.) 2001;100(1):2-3.
2001: Michael J Czar; Ellen N Kersh; Lilia Mijares; G Lanier; J Lewis; G Yap; Amy Chen; Alan Sher; Colin S Duckett; Rafi Ahmed; Pamela L Schwartzberg
Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7449-54.
2001: CM Lewis; Christine Broussard; Michael J Czar; Pamela L Schwartzberg
Tec kinases: modulators of lymphocyte signaling and development.
Current opinion in immunology 2001;13(3):317-25.
2001: Mario Chamorro; Michael J Czar; Jayanta Debnath; G Cheng; Michael J Lenardo; Harold Varmus; Pamela L Schwartzberg
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
BMC immunology 2001;2():3.
2000: Kay-Uwe Wagner; Estefania Claudio; Edmund B Rucker; Gregory Riedlinger; Christine Broussard; Pamela L Schwartzberg; Ulrich Siebenlist; Lothar Hennighausen
Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly.
Development (Cambridge, England) 2000;127(22):4949-58.
2000: Edward M Schaeffer; Christine Broussard; Jayanta Debnath; S Anderson; Daniel W McVicar; Pamela L Schwartzberg
Tec family kinases modulate thresholds for thymocyte development and selection.
The Journal of experimental medicine 2000;192(7):987-1000.
2000: X Shan; Michael J Czar; Stephen C Bunnell; Pinghu Liu; Yusen Liu; Pamela L Schwartzberg; Ronald L Wange
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
Molecular and cellular biology 2000;20(18):6945-57.
2000: Edward M Schaeffer; Pamela L Schwartzberg
Tec family kinases in lymphocyte signaling and function.
Current opinion in immunology 2000;12(3):282-8.
2000: Z Sun; Christopher W Arendt; Wilfried Ellmeier; Edward M Schaeffer; Mary Jean Sunshine; L Gandhi; Justin P Annes; D Petrzilka; Abraham Kupfer; Pamela L Schwartzberg; Dan R Littman
PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes.
Nature 2000;404(6776):402-7.
1999: EM Schaeffer; Jayanta Debnath; G Yap; Daniel W McVicar; X C Liao; Dan R Littman; Alan Sher; Harold Varmus; Michael J Lenardo; Pamela L Schwartzberg
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.) 1999;284(5414):638-41.
1999: Jayanta Debnath; Mario Chamorro; Michael J Czar; EM Schaeffer; Michael J Lenardo; Harold Varmus; Pamela L Schwartzberg
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.
Molecular and cellular biology 1999;19(2):1498-507.
1995: Q Hu; David Davidson; Pamela L Schwartzberg; F Macchiarini; Michael J Lenardo; J A Bluestone; L A Matis
Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage.
The Journal of biological chemistry 1995;270(4):1928-34.
1994: Juan Carlos Zúñiga-Pflücker; D Jiang; Pamela L Schwartzberg; Michael J Lenardo
Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice.
The Journal of experimental medicine 1994;180(4):1517-21.