Edward Schwarz

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Anatomy

Chemicals & Drugs

Physiology

Disorders

Osteolysis

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Publications

TOP 3
Darowish Michael; Rahman Ra'Kerry; Li Ping; Bukata Susan V; Gelinas Jill; Huang Willis; Flick Lisa M; Schwarz Edward M; O'Keefe Regis J
Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation.
Guo Ruolin; Zhou Quan; Proulx Steven T; Wood Ronald; Ji Rui-Cheng; Ritchlin Christopher T; Pytowski Bronislaw; Zhu Zhenping; Wang Yong-Jun; Schwarz Edward M; Xing Lianping
Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis.
Xie Chao; Liang Bojian; Xue Ming; Lin Angela S P; Loiselle Alayna; Schwarz Edward M; Guldberg Robert E; O'Keefe Regis J; Zhang Xinping
Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

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All Publications

2009: Darowish Michael; Rahman Ra'Kerry; Li Ping; Bukata Susan V; Gelinas Jill; Huang Willis; Flick Lisa M; Schwarz Edward M; O'Keefe Regis J
Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation.
Bone 2009;45(4):661-8.
2009: Guo Ruolin; Zhou Quan; Proulx Steven T; Wood Ronald; Ji Rui-Cheng; Ritchlin Christopher T; Pytowski Bronislaw; Zhu Zhenping; Wang Yong-Jun; Schwarz Edward M; Xing Lianping
Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis.
Arthritis and rheumatism 2009;60(9):2666-76.
2009: Xie Chao; Liang Bojian; Xue Ming; Lin Angela S P; Loiselle Alayna; Schwarz Edward M; Guldberg Robert E; O'Keefe Regis J; Zhang Xinping
Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.
The American journal of pathology 2009;175(2):772-85.
2009: Crane Daniel P; Gromov Kirill; Li Dan; Søballe Kjeld; Wahnes Christian; Büchner Hubert; Hilton Matthew J; O'Keefe Regis J; Murray Clinton K; Schwarz Edward M
Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(8):1008-15.
2009: Loiselle Alayna E; Bragdon Gwynne A; Jacobson Justin A; Hasslund Sys; Cortes Zenia E; Schwarz Edward M; Mitten David J; Awad Hani A; O'Keefe Regis J
Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(6):833-40.
2009: Reynolds David G; Shaikh Saad; Papuga Mark Owen; Lerner Amy L; O'Keefe Regis J; Schwarz Edward M; Awad Hani A
muCT-based measurement of cortical bone graft-to-host union.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(5):899-907.
2009: Naik Amish A; Xie Chao; Zuscik Michael J; Kingsley Paul; Schwarz Edward M; Awad Hani; Guldberg Robert; Drissi Hicham; Puzas J Edward; Boyce Brendan; Zhang Xinping; O'Keefe Regis J
Reduced COX-2 expression in aged mice is associated with impaired fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(2):251-64.
2008: Xie Chao; Ming Xue; Wang Qun; Schwarz Edward M; Guldberg Robert E; O'Keefe Regis J; Zhang Xinping
COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.
Bone 2008;43(6):1075-83.
2008: Wu Qiuqian; Kim Kyung-Ok; Sampson Erik R; Chen Di; Awad Hani; O'Brien Todd; Puzas J Edward; Drissi Hicham; Schwarz Edward M; O'Keefe Regis J; Zuscik Michael J; Rosier Randy N
Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.
Arthritis and rheumatism 2008;58(10):3132-44.
2008: Yazici Cemal; Yanoso Laura; Xie Chao; Reynolds David G; Samulski R Jude; Samulski Jade; Yannariello-Brown Judith; Gertzman Arthur A; Zhang Xinping; Awad Hani A; Schwarz Edward M
The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.
Biomaterials 2008;29(28):3882-7.
2008: Tsutsumi Ryosuke; Hock Colleen; Bechtold C Dustin; Proulx Steven T; Bukata Susan V; Ito Hiromu; Awad Hani A; Nakamura Takashi; O'Keefe Regis J; Schwarz Edward M
Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(10):1340-6.
2008: Kaback Lee A; Soung Do Y; Naik Amish; Geneau Graziello; Schwarz Edward M; Rosier Randy N; O'Keefe Regis J; Drissi Hicham
Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.
Journal of cellular biochemistry 2008;105(1):219-26.
2008: Mensah Kofi A; Schwarz Edward M; Ritchlin Christopher T
Altered bone remodeling in psoriatic arthritis.
Current rheumatology reports 2008;10(4):311-7.
2008: Guo Ruolin; Yamashita Motozo; Zhang Qian; Zhou Quan; Chen Di; Reynolds David G; Awad Hani A; Yanoso Laura; Zhao Lan; Schwarz Edward M; Zhang Ying E; Boyce Brendan F; Xing Lianping
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.
The Journal of biological chemistry 2008;283(34):23084-92.
2008: Zhang Xinping; Awad Hani A; O'Keefe Regis J; Guldberg Robert E; Schwarz Edward M
A perspective: engineering periosteum for structural bone graft healing.
Clinical orthopaedics and related research 2008;466(8):1777-87.
2008: Eliseev R A; Dong Y-F; Sampson E; Zuscik M J; Schwarz E M; O'Keefe R J; Rosier R N; Drissi M H
Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.
Oncogene 2008;27(25):3605-14.
2008: Hasslund Sys; Jacobson Justin A; Dadali Tulin; Basile Patrick; Ulrich-Vinther Michael; Søballe Kjeld; Schwarz Edward M; O'Keefe Regis J; Mitten David J; Awad Hani A
Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(6):824-33.
2008: Zhang Qian; Guo Ruolin; Lu Yan; Zhao Lan; Zhou Quan; Schwarz Edward M; Huang Jing; Chen Di; Jin Zheng-Gen; Boyce Brendan F; Xing Lianping
VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.
The Journal of biological chemistry 2008;283(19):13491-9.
2008: Yao Zhenqiang; Xing Lianping; Qin Chunlin; Schwarz Edward M; Boyce Brendan F
Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.
The Journal of biological chemistry 2008;283(15):9917-24.
2008: Basile Patrick; Dadali Tulin; Jacobson Justin; Hasslund Sys; Ulrich-Vinther Michael; Søballe Kjeld; Nishio Yasuhiko; Drissi M Hicham; Langstein Howard N; Mitten David J; O'Keefe Regis J; Schwarz Edward M; Awad Hani A
Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):466-73.
2008: Xie Chao; Xue Ming; Wang Qun; Schwarz Edward M; O'Keefe Regis J; Zhang Xinping
Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.
The Journal of bone and joint surgery. American volume 2008;90 Suppl 1():9-13.
2008: Li Dan; Gromov Kirill; Søballe Kjeld; Puzas J Edward; O'Keefe Regis J; Awad Hani; Drissi Hicham; Schwarz Edward M
Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(1):96-105.
2008: Kaback Lee A; Soung Do Y; Naik Amish; Smith Nathan; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.
Journal of cellular physiology 2008;214(1):173-82.
2008: Schwarz Edward M;
What potential biologic treatments are available for osteolysis?
The Journal of the American Academy of Orthopaedic Surgeons 2008;16 Suppl 1():S72-5.
2008: Zhang Qian; Guo Ruolin; Schwarz Edward M; Boyce Brendan F; Xing Lianping
TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood.
Arthritis research & therapy 2008;10(2):R37.
2007: Proulx Steven T; Kwok Edmund; You Zhigang; Papuga M Owen; Beck Christopher A; Shealy David J; Ritchlin Christopher T; Awad Hani A; Boyce Brendan F; Xing Lianping; Schwarz Edward M
Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography.
Arthritis and rheumatism 2007;56(12):4024-37.
2007: Boyce Brendan F; Yao Zhenqiang; Zhang Qian; Guo Roulin; Lu Yan; Schwarz Edward M; Xing Lianping
New roles for osteoclasts in bone.
Annals of the New York Academy of Sciences 2007;1116():245-54.
2007: Dong Yu-Feng; Soung Do Y; Chang Yoon; Enomoto-Iwamoto Motomi; Paris Mark; O'Keefe Regis J; Schwarz Edward M; Drissi Hicham
Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2805-20.
2007: Proulx Steven T; Kwok Edmund; You Zhigang; Beck Christopher A; Shealy David J; Ritchlin Christopher T; Boyce Brendan F; Xing Lianping; Schwarz Edward M
MRI and quantification of draining lymph node function in inflammatory arthritis.
Annals of the New York Academy of Sciences 2007;1117():106-23.
2007: Zuscik Michael J; Ma Lin; Buckley Taylor; Puzas J Edward; Drissi Hicham; Schwarz Edward M; O'Keefe Regis J
Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations.
Environmental health perspectives 2007;115(9):1276-82.
2007: Awad Hani A; Zhang Xinping; Reynolds David G; Guldberg Robert E; O'Keefe Regis J; Schwarz Edward M
Recent advances in gene delivery for structural bone allografts.
Tissue engineering 2007;13(8):1973-85.
2007: Soung Do Y; Dong Yufeng; Wang YongJun; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(8):1260-70.
2007: Kimelman Nadav; Pelled Gadi; Helm Gregory A; Huard J; Schwarz Edward M; Gazit Dan
Review: gene- and stem cell-based therapeutics for bone regeneration and repair.
Tissue engineering 2007;13(6):1135-50.
2007: Yamashita Teruhito; Yao Zhenqiang; Li Fang; Zhang Qian; Badell I Raul; Schwarz Edward M; Takeshita Sunao; Wagner Erwin F; Noda Masaki; Matsuo Koichi; Xing Lianping; Boyce Brendan F
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.
The Journal of biological chemistry 2007;282(25):18245-53.
2007: Xie Chao; Reynolds David; Awad Hani; Rubery Paul T; Pelled Gadi; Gazit Dan; Guldberg Robert E; Schwarz Edward M; O'Keefe Regis J; Zhang Xinping
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.
Tissue engineering 2007;13(3):435-45.
2007: Zhang Qian; Lu Yan; Proulx Steven T; Guo Ruolin; Yao Zhenqiang; Schwarz Edward M; Boyce Brendan F; Xing Lianping
Increased lymphangiogenesis in joints of mice with inflammatory arthritis.
Arthritis research & therapy 2007;9(6):R118.
2007: Schwarz Edward M; Ritchlin Christopher T
Clinical development of anti-RANKL therapy.
Arthritis research & therapy 2007;9 Suppl 1():S7.
2007: Reynolds David G; Hock Colleen; Shaikh Saad; Jacobson Justin; Zhang Xinping; Rubery Paul T; Beck Christopher A; O'keefe Regis J; Lerner Amy L; Schwarz Edward M; Awad Hani A
Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts.
Journal of biomechanics 2007;40(14):3178-86.
2006: Robertson Galen; Xie Chao; Chen Di; Awad Hani; Schwarz Edward M; O'Keefe Regis J; Guldberg Robert E; Zhang Xinping
Alteration of femoral bone morphology and density in COX-2-/- mice.
Bone 2006;39(4):767-72.
2006: Boyce Brendan F; Schwarz Edward M; Xing Lianping
Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease.
Current opinion in rheumatology 2006;18(4):427-32.
2006: Li Tian-Fang; Chen Di; Wu Qiuqian; Chen Mo; Sheu Tzong-Jen; Schwarz Edward M; Drissi Hicham; Zuscik Michael; O'Keefe Regis J
Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.
The Journal of biological chemistry 2006;281(30):21296-304.
2006: Dong Yu-Feng; Soung Do Y; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
Journal of cellular physiology 2006;208(1):77-86.
2006: Nishio Yasuhiko; Dong Yufeng; Paris Mark; O'Keefe Regis J; Schwarz Edward M; Drissi Hicham
Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.
Gene 2006;372():62-70.
2006: Schwarz Edward M; Looney R John; Drissi M Hicham; O'Keefe Regis J; Boyce Brendan F; Xing Lianping; Ritchlin Christopher T
Autoimmunity and bone.
Annals of the New York Academy of Sciences 2006;1068():275-83.
2006: Maloney Michael D; Goater J Jeffrey; Parsons Richard; Ito Hiromu; O'Keefe Regis J; Rubery Paul T; Drissi M Hicham; Schwarz Edward M
Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects.
The Journal of bone and joint surgery. American volume 2006;88(4):753-61.
2006: Kaneki Hiroyuki; Guo Ruolin; Chen Di; Yao Zhenqiang; Schwarz Edward M; Zhang Ying E; Boyce Brendan F; Xing Lianping
Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.
The Journal of biological chemistry 2006;281(7):4326-33.
2006: Li Tian-Fang; Darowish Michael; Zuscik Michael J; Chen Di; Schwarz Edward M; Rosier Randy N; Drissi Hicham; O'Keefe Regis J
Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(1):4-16.
2006: Looney R John; Schwarz Edward M; Boyd Allen; O'Keefe Regis J
Periprosthetic osteolysis: an immunologist's update.
Current opinion in rheumatology 2006;18(1):80-7.
2006: Eliseev Roman A; Schwarz Edward M; Zuscik Michael J; O'Keefe Regis J; Drissi Hicham; Rosier Randy N
Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.
Experimental cell research 2006;312(1):40-50.
2005: Andela Valentine B; Schwarz Edward M; O'Keefe Regis J; Puzas Edward J; Rosenblatt Joseph D; Rosier Randy N
A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival.
FEBS letters 2005;579(30):6814-20.
2005: Xing Lianping; Schwarz Edward M; Boyce Brendan F
Osteoclast precursors, RANKL/RANK, and immunology.
Immunological reviews 2005;208():19-29.
2005: Zhang Xinping; Xie Chao; Lin Angela S P; Ito Hiromu; Awad Hani; Lieberman Jay R; Rubery Paul T; Schwarz Edward M; O'Keefe Regis J; Guldberg Robert E
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(12):2124-37.
2005: Ulrich-Vinther Michael; Schwarz Edward M; Pedersen Finn S; Søballe Kjeld; Andreassen Troels T
Gene therapy with human osteoprotegerin decreases callus remodeling with limited effects on biomechanical properties.
Bone 2005;37(6):751-8.
2005: Eliseev Roman A; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham; Rosier Randy N
Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.
Journal of cellular biochemistry 2005;96(6):1262-73.
2005: Ulrich-Vinther M; Stengaard C; Schwarz E M; Goldring M B; Soballe K
Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism.
European cells & materials 2005;10():40-50.
2005: Soloviev Alexander; Schwarz Edward M; Darowish Michael; O'Keefe Regis J
Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005;23(6):1258-65.
2005: Boyce Brendan F; Li Ping; Yao Zhenqiang; Zhang Qian; Badell I Raul; Schwarz Edward M; O'Keefe Regis J; Xing Lianping
TNF-alpha and pathologic bone resorption.
The Keio journal of medicine 2005;54(3):127-31.
2005: Zhang Q; Badell I R; Schwarz E M; Boulukos K E; Yao Z; Boyce B F; Xing L
Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2.
Arthritis and rheumatism 2005;52(9):2708-18.
2005: Wang YongJun; Belflower Ruth M; Dong Yu-Feng; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(9):1624-36.
2005: Koefoed Mette; Ito Hiromu; Gromov Kirill; Reynolds David G; Awad Hani A; Rubery Paul T; Ulrich-Vinther Michael; Soballe Kjeld; Guldberg Robert E; Lin Angela S P; O'Keefe Regis J; Zhang Xinping; Schwarz Edward M
Biological effects of rAAV-caAlk2 coating on structural allograft healing.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):212-8.
2005: Dong Yufeng; Drissi Hicham; Chen Mo; Chen Di; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J
Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta.
Journal of cellular biochemistry 2005;95(5):1057-68.
2005: Wei Xiaochao; Zhang Xinping; Zuscik Michael J; Drissi M Hicham; Schwarz Edward M; O'Keefe Regis J
Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(7):1136-48.
2005: Carmouche Jonathan J; Puzas J Edward; Zhang Xinping; Tiyapatanaputi Prarop; Cory-Slechta Deborah A; Gelein Robert; Zuscik Michael; Rosier Randy N; Boyce Brendan F; O'Keefe Regis J; Schwarz Edward M
Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.
Environmental health perspectives 2005;113(6):749-55.
2005: Gordon Andrew H; O'Keefe Regis J; Schwarz Edward M; Rosier Randy N; Puzas J Edward
Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.
Cancer research 2005;65(8):3209-17.
2005: Smith Nathan; Dong Yufeng; Lian Jane B; Pratap Jitesh; Kingsley Paul D; van Wijnen Andre J; Stein Janet L; Schwarz Edward M; O'Keefe Regis J; Stein Gary S; Drissi M Hicham
Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development.
Journal of cellular physiology 2005;203(1):133-43.
2005: Ito Hiromu; Koefoed Mette; Tiyapatanaputi Prarop; Gromov Kirill; Goater J Jeffrey; Carmouche Jonathan; Zhang Xinping; Rubery Paul T; Rabinowitz Joseph; Samulski R Jude; Nakamura Takashi; Soballe Kjeld; O'Keefe Regis J; Boyce Brendan F; Schwarz Edward M
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.
Nature medicine 2005;11(3):291-7.
2005: Clark Christine A; Schwarz Edward M; Zhang Xinping; Ziran Navid M; Drissi Hicham; O'Keefe Regis J; Zuscik Michael J
Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.
Biochemical and biophysical research communications 2005;328(3):764-76.
2004: Guldberg R E; Oest M; Lin A S P; Ito H; Chao X; Gromov K; Goater J J; Koefoed M; Schwarz E M; O'Keefe R J; Zhang X
Functional integration of tissue-engineered bone constructs.
Journal of musculoskeletal & neuronal interactions 2004;4(4):399-400.
2004: Schwarz E M; O'Keefe R J; Looney R J
Bone implant interface, osteolysis and potential therapies.
Journal of musculoskeletal & neuronal interactions 2004;4(4):390-2.
2004: Tiyapatanaputi Prarop; Rubery Paul T; Carmouche Jonathan; Schwarz Edward M; O'keefe Regis J; Zhang Xinping
A novel murine segmental femoral graft model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(6):1254-60.
2004: Li Tian-Fang; Zuscik Michael J; Ionescu Andreia M; Zhang Xinping; Rosier Randy N; Schwarz Edward M; Drissi Hicham; O'Keefe Regis J
PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.
Experimental cell research 2004;300(1):159-69.
2004: Ritchlin C T; Schwarz E M; O'Keefe R J; Looney R J
RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis.
Journal of musculoskeletal & neuronal interactions 2004;4(3):276-84.
2004: Li Tian-Fang; Dong Yufeng; Ionescu Andreia M; Rosier Randy N; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.
Experimental cell research 2004;299(1):128-36.
2004: Ulrich-Vinther M; Duch M R; Søballe K; O'Keefe R J; Schwarz E M; Pedersen F S
In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(4):726-34.
2004: Ferguson Cristin M; Schwarz Edward M; Puzas J Edward; Zuscik Michael J; Drissi Hicham; O'Keefe Regis J
Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(4):687-96.
2004: Zhang Xinping; Ziran Navid; Goater J Jeffery; Schwarz Edward M; Puzas J Edward; Rosier Randy N; Zuscik Michael; Drissi Hicham; O'Keefe Regis J
Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.
Bone 2004;34(5):809-17.
2004: Zuscik Michael J; Baden Jonathan F; Wu Qiuqian; Sheu Tzong J; Schwarz Edward M; Drissi Hicham; O'Keefe Regis J; Puzas J Edward; Rosier Randy N
5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.
Journal of cellular biochemistry 2004;92(2):316-31.
2004: Ionescu Andreia M; Drissi Hicham; Schwarz Edward M; Kato Mitsuyasu; Puzas J Edward; McCance Dennis J; Rosier Randy N; Zuscik Michael J; O'Keefe Regis J
CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.
Journal of cellular physiology 2004;198(3):428-40.
2004: Li Ping; Schwarz Edward M; O'Keefe Regis J; Ma Lin; Boyce Brendan F; Xing Lianping
RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(2):207-13.
2004: Li Ping; Schwarz Edward M; O'Keefe Regis J; Ma Lin; Looney R John; Ritchlin Christopher T; Boyce Brendan F; Xing Lianping
Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.
Arthritis and rheumatism 2004;50(1):265-76.
2004: Ito H; Goater J J; Tiyapatanaputi P; Rubery P T; O'Keefe R J; Schwarz E M
Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells.
Gene therapy 2004;11(1):34-41.
2004: Bukata Susan V; Gelinas Jill; Wei Xiaochao; Rosier Randy N; Puzas J Edward; Zhang Xinping; Schwarz Edward M; Song Xiao-yu R; Griswold Don E; O'Keefe Regis J
PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(1):6-12.
2003: Puzas J E; O'Keefe R J; Schwarz E M; Zhang X
Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition.
Journal of musculoskeletal & neuronal interactions 2003;3(4):308-12; discussion 320-1.
2003: Drissi M Hicham; Li Xufeng; Sheu Tzong J; Zuscik Michael J; Schwarz Edward M; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.
Journal of cellular biochemistry 2003;90(6):1287-98.
2003: Huang W; Drissi M H; O'Keefe R J; Schwarz E M
A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis.
Calcified tissue international 2003;73(6):584-93.
2003: Ulrich-Vinther Michael; Maloney Michael D; Schwarz Edward M; Rosier Randy; O'Keefe Regis J
Articular cartilage biology.
The Journal of the American Academy of Orthopaedic Surgeons 2003;11(6):421-30.
2003: Schwarz Edward M; Campbell Debbie; Totterman Saara; Boyd Allen; O'Keefe Regis J; Looney R John
Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(6):1049-55.
2003: Andela Valentine B; Gordon Andrew H; Zotalis George; Rosier Randy N; Goater Jeffrey J; Lewis Gregory D; Schwarz Edward M; Puzas J Edward; O'Keefe Regis J
NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.
Clinical orthopaedics and related research 2003;(415 Suppl):S75-85.
2003: Andela Valentine B; Pirri Michael; Schwarz Edward M; Puzas Edward J; O'Keefe Regis J; Rosenblatt Joseph D; Rosier Randy N
The mevalonate synthesis pathway as a therapeutic target in cancer.
Clinical orthopaedics and related research 2003;(415 Suppl):S59-66.
2003: Zhang Donghui; Schwarz Edward M; Rosier Randy N; Zuscik Michael J; Puzas J Edward; O'Keefe Regis J
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(9):1593-604.
2003: Li Xeufeng; Ionescu Andreia M; Schwarz Edward M; Zhang Xinping; Drissi Hicham; Puzas J Edward; Rosier Randy N; Zuscik Michael J; O'Keefe Regis J
Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(5):908-13.
2003: Li Ping; Schwarz Edward M
The TNF-alpha transgenic mouse model of inflammatory arthritis.
Springer seminars in immunopathology 2003;25(1):19-33.
2003: Ionescu Andreia M; Schwarz Edward M; Zuscik Michael J; Drissi Hicham; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation.
Experimental cell research 2003;288(1):198-207.
2003: Flick Lisa M; Weaver Jason M; Ulrich-Vinther Michael; Abuzzahab Faruk; Zhang Xinping; Dougall William C; Anderson Dirk; O'Keefe Regis J; Schwarz Edward M
Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(4):676-84.
2003: Li Xuefeng; Schwarz Edward M; Zuscik Michael J; Rosier Randy N; Ionescu Andreia M; Puzas J Edward; Drissi Hicham; Sheu Tzong-Jen; O'Keefe Regis J
Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.
Endocrinology 2003;144(6):2514-23.
2003: Andela Valentine B; Gingold Brett I; Souza Mary D; O'Keefe Regis J; Puzas Edward J; Schwarz Edward M; Rosier Randy N
Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.
Cancer letters 2003;194(1):37-43.
2003: Sheu Tzong-Jen; Schwarz Edward M; Martinez Daniel A; O'Keefe Regis J; Rosier Randy N; Zuscik Michael J; Puzas J Edward
A phage display technique identifies a novel regulator of cell differentiation.
The Journal of biological chemistry 2003;278(1):438-43.
2003: Huang Willis; O'Keefe Regis J; Schwarz Edward M
Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation.
Arthritis research & therapy 2003;5(1):R49-59.
2002: Huang Willis; Schwarz Edward M
Mechanisms of bone resorption and new bone formation in spondyloarthropathies.
Current rheumatology reports 2002;4(6):513-7.
2002: Zuscik Michael J; O'Keefe Regis J; Gunter Thomas E; Puzas J Edward; Schwarz Edward M; Rosier Randy N
Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(5):1079-90.
2002: Andela Valentine B; Sheu Tzong-Jen; Puzas Edward J; Schwarz Edward M; O'Keefe Regis J; Rosier Randy N
Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB.
Biochemical and biophysical research communications 2002;297(2):237-41.
2002: Ulrich-Vinther Michael; Maloney Michael D; Goater J Jeffrey; Søballe Kjeld; Goldring Mary B; O'Keefe Regis J; Schwarz Edward M
Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes.
Arthritis and rheumatism 2002;46(8):2095-104.
2002: Ulrich-Vinther Michael; Carmody Emily E; Goater J Jeffrey; S balle Kjeld; O'Keefe Regis J; Schwarz Edward M
Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis.
The Journal of bone and joint surgery. American volume 2002;84-A(8):1405-12.
2002: Zuscik Michael J; Pateder Dhruv B; Puzas J Edward; Schwarz Edward M; Rosier Randy N; O'Keefe Regis J
Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(4):811-8.
2002: Soloviev Alexander; Schwarz Edward M; Kuprash Dmitry V; Nedospasov Sergei A; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(4):714-22.
2002: Zhang Xinping; Schwarz Edward M; Young Donald A; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.
The Journal of clinical investigation 2002;109(11):1405-15.
2002: Zuscik Michael J; D'Souza Mary; Ionescu Andreia M; Gunter Karlene K; Gunter Thomas E; O'Keefe Regis J; Schwarz Edward M; Puzas J Edward; Rosier Randy N
Growth plate chondrocyte maturation is regulated by basal intracellular calcium.
Experimental cell research 2002;276(2):310-9.
2002: Carmody Emily E; Schwarz Edward M; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles.
Arthritis and rheumatism 2002;46(5):1298-308.
2002: Sheu Tzong-Jen; Schwarz Edward M; O'Keefe Regis J; Rosier Randy N; Puzas J Edward
Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(5):915-22.
2002: Andela Valentine B; Rosenblatt Joseph D; Schwarz Edward M; Puzas Edward J; O'Keefe Regis J; Rosier Randy N
Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis.
Clinical orthopaedics and related research 2002;(397):228-39.
2002: Goater J Jeffrey; O'Keefe Regis J; Rosier Randy N; Puzas J Edward; Schwarz Edward M
Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(2):169-73.
2002: Good Christopher R; O'Keefe Regis J; Puzas J Edward; Schwarz Edward M; Rosier Randy N
Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors.
Journal of surgical oncology 2002;79(3):174-9.
2002: Childs Lisa M; Paschalis Eleftherios P; Xing Lianping; Dougall William C; Anderson Dirk; Boskey Adele L; Puzas J Edward; Rosier Randy N; O'Keefe Regis J; Boyce Brendan F; Schwarz Edward M
In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(2):192-9.
2002: Mungo David V; Zhang Xinping; O'Keefe Regis J; Rosier Randy N; Puzas J Edward; Schwarz Edward M
COX-1 and COX-2 expression in osteoid osteomas.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(1):159-62.
2002: Pateder Dhruv B; Sheu Tzong Jen; O'Keefe Regis J; Puzas J Edward; Schwarz Edward M; Constine Louis S; Okunieff Paul; Rosier Randy N
Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes.
Radiation research 2002;157(1):62-8.
2002: Looney R John; Boyd Allen; Totterman Saara; Seo Gwy-Suk; Tamez-Pena Jose; Campbell Debbie; Novotny Leonore; Olcott Christopher; Martell John; Hayes F Ann; O'Keefe Regis J; Schwarz Edward M
Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear.
Arthritis research 2002;4(1):59-63.
2001: Childs L M; Goater J J; O'Keefe R J; Schwarz E M
Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis.
The Journal of bone and joint surgery. American volume 2001;83-A(12):1789-97.
2001: Pateder D B; Ferguson C M; Ionescu A M; Schwarz E M; Rosier R N; Puzas J E; O'Keefe R J
PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling.
Journal of cellular physiology 2001;188(3):343-51.
2001: Pollice P F; Rosier R N; Looney R J; Puzas J E; Schwarz E M; O'Keefe R J
Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components.
The Journal of bone and joint surgery. American volume 2001;83-A(7):1057-61.
2001: Pateder D B; Eliseev R A; O'Keefe R J; Schwarz E M; Okunieff P; Constine L S; Puzas J E; Rosier R N
The role of autocrine growth factors in radiation damage to the epiphyseal growth plate.
Radiation research 2001;155(6):847-57.
2001: Zhang X; Morham S G; Langenbach R; Young D A; Xing L; Boyce B F; Puzas E J; Rosier R N; O'Keefe R J; Schwarz E M
Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):660-70.
2001: Ionescu A M; Schwarz E M; Vinson C; Puzas J E; Rosier R; Reynolds P R; O'Keefe R J
PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling.
The Journal of biological chemistry 2001;276(15):11639-47.
2001: Childs L M; Goater J J; O'Keefe R J; Schwarz E M
Efficacy of etanercept for wear debris-induced osteolysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):338-47.
2001: Grimsrud C D; Romano P R; D'Souza M; Puzas J E; Schwarz E M; Reynolds P R; Roiser R N; O'Keefe R J
BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(1):18-25.
2000: Andela V B; Schwarz E M; Puzas J E; O'Keefe R J; Rosier R N
Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.
Cancer research 2000;60(23):6557-62.
2000: Ferguson C M; Schwarz E M; Reynolds P R; Puzas J E; Rosier R N; O'Keefe R J
Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation.
Endocrinology 2000;141(12):4728-35.
2000: Schwarz E M; Benz E B; Lu A P; Goater J J; Mollano A V; Rosier R N; Puzas J E; Okeefe R J
Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(6):849-55.
2000: Schwarz E M
The adeno-associated virus vector for orthopaedic gene therapy.
Clinical orthopaedics and related research 2000;(379 Suppl):S31-9.
2000: Li P; Sanz I; O'Keefe R J; Schwarz E M
NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5990-7.
2000: Schwarz E M; Lu A P; Goater J J; Benz E B; Kollias G; Rosier R N; Puzas J E; O'Keefe R J
Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):472-80.
2000: Pateder D B; Rosier R N; Schwarz E M; Reynolds P R; Puzas J E; D'Souza M; O'Keefe R J
PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes.
Experimental cell research 2000;256(2):555-62.
2000: Goater J; Müller R; Kollias G; Firestein G S; Sanz I; O'Keefe R J; Schwarz E M
Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.
The Journal of rheumatology 2000;27(4):983-9.
2000: Schwarz E M; Looney R J; O'Keefe R J
Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis.
Arthritis research 2000;2(3):165-8.

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