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Frank Schweizer

Research Profile

Procedures

Microbial Sensitivity Tests

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George G Zhanel; Heather J Adam; Melanie R Baxter; Andrew J Denisuik; Jeff Fuller; Daryl J Hoban; James A Karlowsky; Philippe R S Lagacé-Wiens; Kimberly A Nichol; Frank Schweizer; Andrew Walkty
Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study.
Yaozu Xu; Gilbert Arthur; Makanjuola Ogunsina; Pranati Samadder; Frank Schweizer
Structure-activity relationships of glucosamine-derived glycerolipids: the role of the anomeric linkage, the cationic charge and the glycero moiety on the antitumor activity.
George G Zhanel; Heather Adam; Andrew Denisuik; Alfred Gin; Daryl J Hoban; Philippe R S Lagacé-Wiens; Christopher D Lawson; Joseph P Lynch; Ethan Rubinstein; Frank Schweizer; Sheryl A Zelenitsky; James A Karlowsky
Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination.

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All Publications

2013: George G Zhanel; Heather J Adam; Melanie R Baxter; Andrew J Denisuik; Jeff Fuller; Daryl J Hoban; James A Karlowsky; Philippe R S Lagacé-Wiens; Kimberly A Nichol; Frank Schweizer; Andrew Walkty
Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study.
The Journal of antimicrobial chemotherapy 2013;68 Suppl 1():i7-i22.
2013: Yaozu Xu; Gilbert Arthur; Makanjuola Ogunsina; Pranati Samadder; Frank Schweizer
Structure-activity relationships of glucosamine-derived glycerolipids: the role of the anomeric linkage, the cationic charge and the glycero moiety on the antitumor activity.
ChemMedChem 2013;8(3):511-20.
2013: George G Zhanel; Heather Adam; Andrew Denisuik; Alfred Gin; Daryl J Hoban; Philippe R S Lagacé-Wiens; Christopher D Lawson; Joseph P Lynch; Ethan Rubinstein; Frank Schweizer; Sheryl A Zelenitsky; James A Karlowsky
Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination.
Drugs 2013;73(2):159-77.
2013: Robel B Teklebrhan; Stacey D Wetmore; James D Xidos; Neil W Owens; Georg Schreckenbach; Frank Schweizer
Conformational preference of fused carbohydrate-templated proline analogues--a computational study.
The journal of physical chemistry. B 2013;117(1):199-205.
2013: Brandon Findlay; Neeloffer Mookherjee; Frank Schweizer
Ultrashort cationic lipopeptides and lipopeptoids selectively induce cytokine production in macrophages.
PloS one 2013;8(2):e54280.
2012: Ramesh Dhondikubeer; Smritilekha Bera; George G Zhanel; Frank Schweizer
Antibacterial activity of amphiphilic tobramycin.
The Journal of antibiotics 2012;65(10):495-8.
2012: Brandon Findlay; George G Zhanel; Frank Schweizer
Investigating the antimicrobial peptide 'window of activity' using cationic lipopeptides with hydrocarbon and fluorinated tails.
International journal of antimicrobial agents 2012;40(1):36-42.
2012: George G Zhanel; Heather Adam; Brandon Findlay; Alfred Gin; Daryl J Hoban; Christopher D Lawson; Joseph P Lynch; Ethan Rubinstein; Frank Schweizer; Andrew Walkty; Sheryl A Zelenitsky; James A Karlowsky
Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.
Expert review of anti-infective therapy 2012;10(4):459-73.
2012: Brandon Findlay; George G Zhanel; Frank Schweizer
Neomycin-phenolic conjugates: polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding.
Bioorganic & medicinal chemistry letters 2012;22(4):1499-503.
2012: Smritilekha Bera; Ramesh Dhondikubeer; Brandon Findlay; George G Zhanel; Frank Schweizer
Synthesis and antibacterial activities of amphiphilic neomycin B-based bilipid conjugates and fluorinated neomycin B-based lipids.
Molecules (Basel, Switzerland) 2012;17(8):9129-41.
2012: Brandon Findlay; Paul Szelemej; George G Zhanel; Frank Schweizer
Guanidylation and tail effects in cationic antimicrobial lipopeptoids.
PloS one 2012;7(7):e41141.
2011: Smritilekha Bera; George G Zhanel; Frank Schweizer
Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates.
Carbohydrate research 2011;346(5):560-8.
2011: Dhananjoy Mondal; George G Zhanel; Frank Schweizer
Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants.
Carbohydrate research 2011;346(5):588-94.
2010: Brandon Findlay; George G Zhanel; Frank Schweizer
Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.
Antimicrobial agents and chemotherapy 2010;54(10):4049-58.
2010: Robel B Teklebrhan; Kaidong Zhang; Georg Schreckenbach; Frank Schweizer; Stacey D Wetmore
Intramolecular hydrogen bond-controlled prolyl amide isomerization in glucosyl 3(S)-hydroxy-5-hydroxymethylproline hybrids: a computational study.
The journal of physical chemistry. B 2010;114(35):11594-602.
2010: Dhananjoy Mondal; Frank Schweizer
Synthesis of allose-templated hydroxyornithine and hydroxyarginine analogs.
Carbohydrate research 2010;345(11):1533-40.
2010: Kaidong Zhang; Frank Schweizer
Influence of glucose-templated proline mimetics on the beta-turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S.
Carbohydrate research 2010;345(9):1114-22.
2010: Smritilekha Bera; George G Zhanel; Frank Schweizer
Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates.
The Journal of antimicrobial chemotherapy 2010;65(6):1224-7.
2010: Smritilekha Bera; George G Zhanel; Frank Schweizer
Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents.
Bioorganic & medicinal chemistry letters 2010;20(10):3031-5.
2010: Smritilekha Bera; George G Zhanel; Frank Schweizer
Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity.
Journal of medicinal chemistry 2010;53(9):3626-31.
2010: George G Zhanel; Divna Calic; Frank Schweizer; Sheryl A Zelenitsky; Heather Adam; Philippe R S Lagacé-Wiens; Ethan Rubinstein; Alfred Gin; Daryl J Hoban; James A Karlowsky
New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin.
Drugs 2010;70(7):859-86.
2010: Neil W Owens; Jörg Stetefeld; Erika Lattová; Frank Schweizer
Contiguous O-galactosylation of 4(R)-hydroxy-l-proline residues forms very stable polyproline II helices.
Journal of the American Chemical Society 2010;132(14):5036-42.
2009: Frank Schweizer
Cationic amphiphilic peptides with cancer-selective toxicity.
European journal of pharmacology 2009;625(1-3):190-4.
2009: Neil W Owens; Adrian Lee; Kirk Marat; Frank Schweizer
The implications of (2S,4S)-hydroxyproline 4-O-glycosylation for prolyl amide isomerization.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(40):10649-57.
2009: Kaidong Zhang; Robel B Teklebrhan; Georg Schreckenbach; Stacey Wetmore; Frank Schweizer
Intramolecular hydrogen bond-controlled prolyl amide isomerization in glucosyl 3'(S)-hydroxy-5'-hydroxymethylproline hybrids: influence of a C-5'-hydroxymethyl substituent on the thermodynamics and kinetics of prolyl amide cis/trans isomerization.
The Journal of organic chemistry 2009;74(10):3735-43.
2009: Griselda N Serrano; George G Zhanel; Frank Schweizer
Antibacterial activity of ultrashort cationic lipo-beta-peptides.
Antimicrobial agents and chemotherapy 2009;53(5):2215-7.
2009: Kaidong Zhang; Frank Schweizer
Design and synthesis of glucose-templated proline-lysine chimera: polyfunctional amino acid chimera with high prolyl cis amide rotamer population.
Carbohydrate research 2009;344(5):576-85.
2009: George G Zhanel; Grace Sniezek; Frank Schweizer; Sheryl A Zelenitsky; Philippe R S Lagacé-Wiens; Ethan Rubinstein; Alfred Gin; Daryl J Hoban; James A Karlowsky
Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus.
Drugs 2009;69(7):809-31.
2008: Smritilekha Bera; George G Zhanel; Frank Schweizer
Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity.
Journal of medicinal chemistry 2008;51(19):6160-4.
2008: Kaidong Zhang; Dhananjoy Mondal; George G Zhanel; Frank Schweizer
Synthesis of glucose-templated lysine analogs and incorporation into the antimicrobial dipeptide sequence kW-OBn.
Carbohydrate research 2008;343(10-11):1644-52.
2008: George G Zhanel; Ashley Lam; Frank Schweizer; Kristjan Thomson; Andrew Walkty; Ethan Rubinstein; Alfred S Gin; Daryl J Hoban; Ayman M Noreddin; James A Karlowsky
Ceftobiprole: a review of a broad-spectrum and anti-MRSA cephalosporin.
American journal of clinical dermatology 2008;9(4):245-54.
2007: Neil W Owens; Craig Braun; Joe D O'Neil; Kirk Marat; Frank Schweizer
Effects of glycosylation of (2S,4R)-4-hydroxyproline on the conformation, kinetics, and thermodynamics of prolyl amide isomerization.
Journal of the American Chemical Society 2007;129(38):11670-1.
2007: Frank Schweizer
Synthesis of fluorescently labelled and internally quenched UDP-Gal probes.
Carbohydrate research 2007;342(12-13):1831-40.
2007: Neil W Owens; Craig Braun; Frank Schweizer
Tuning of the prolyl trans/cis-amide rotamer population by use of C-glucosylproline hybrids.
The Journal of organic chemistry 2007;72(13):4635-43.
2007: Marlin Penner; Frank Schweizer
Ritter-based glycoconjugation of amino acids and peptides--access to novel glycoconjugates displaying a beta-amide linkage between amino acid and sugar moiety.
Carbohydrate research 2007;342(1):7-15.
2006: Frank Schweizer; Ole Hindsgaul
Synthesis of a galacto-configured C-ketoside-based gamma-sugar-amino acid and its use in peptide coupling reactions.
Carbohydrate research 2006;341(10):1730-6.
2002: Anders Lohse; Frank Schweizer; Ole Hindsgaul
Synthesis of a 56 component library of sugar beta-peptides.
Combinatorial chemistry & high throughput screening 2002;5(5):389-94.
2001: Frank Schweizer; Toshiyuki Inazu
Chain extension of sugar delta-lactones with the enolate of tert-butyl bromoacetate and elaboration into functionalized C-ketosides, C-glycosides, and C-glucosyl glycines.
Organic letters 2001;3(25):4115-8.
1999: Frank Schweizer; Ole Hindsgaul
Combinatorial synthesis of carbohydrates.
Current opinion in chemical biology 1999;3(3):291-8.
1998: Frank Schweizer; H Jiao; Ole Hindsgaul; Wah Y Wong; Randall T Irvin
Interaction between the pili of Pseudomonas aeruginosa PAK and its carbohydrate receptor beta-D-GalNAc(1-->4)beta-D-Gal analogs.
Canadian journal of microbiology 1998;44(3):307-11.
1997: A Patricia Campbell; Wah Y Wong; M Houston; Frank Schweizer; PJ Cachia; Randall T Irvin; Ole Hindsgaul; Robert S Hodges; Brian D Sykes
Interaction of the receptor binding domains of Pseudomonas aeruginosa pili strains PAK, PAO, KB7 and P1 to a cross-reactive antibody and receptor analog: implications for synthetic vaccine design.
Journal of molecular biology 1997;267(2):382-402.