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Helmut Schwilden

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Physiology

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Manuel Bornhof; Harald Ihmsen; Helmut Schwilden; David C Yeomans; Alexander Tzabazis
The orofacial formalin test in mice revisited--effects of formalin concentration, age, morphine and analysis method.
Michel M R F Struys; Jörg Fechner; Jürgen Schüttler; Helmut Schwilden
Erroneously published fospropofol pharmacokinetic-pharmacodynamic data and retraction of the affected publications.
Harald Ihmsen; Christian Jeleazcov; Jörg Filitz; Helmut Schwilden; Jürgen Schüttler; Wolfgang Koppert
Increase of propofol requirement after repeated administration for experimental anaesthesia.

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All Publications

2011: Manuel Bornhof; Harald Ihmsen; Helmut Schwilden; David C Yeomans; Alexander Tzabazis
The orofacial formalin test in mice revisited--effects of formalin concentration, age, morphine and analysis method.
The journal of pain : official journal of the American Pain Society 2011;12(6):633-9.
2010: Michel M R F Struys; Jörg Fechner; Jürgen Schüttler; Helmut Schwilden
Erroneously published fospropofol pharmacokinetic-pharmacodynamic data and retraction of the affected publications.
Anesthesiology 2010;112(4):1056-7.
2009: Harald Ihmsen; Christian Jeleazcov; Jörg Filitz; Helmut Schwilden; Jürgen Schüttler; Wolfgang Koppert
Increase of propofol requirement after repeated administration for experimental anaesthesia.
European journal of anaesthesiology 2009;26(9):799-801.
2009: Harald Ihmsen; Joachim Schmidt; Helmut Schwilden; Hubert J Schmitt; Tino Muenster
Influence of disease progression on the neuromuscular blocking effect of mivacurium in children and adolescents with Duchenne muscular dystrophy.
Anesthesiology 2009;110(5):1016-9.
2008: Jörg Filitz; Harald Ihmsen; Werner Günther; Andreas Tröster; Helmut Schwilden; Jürgen Schüttler; Wolfgang Koppert
Supra-additive effects of tramadol and acetaminophen in a human pain model.
Pain 2008;136(3):262-70.
2008: Harald Ihmsen; Michael Schywalsky; Regina Plettke; Michael Priller; Florian Walz; Helmut Schwilden
Concentration-effect relations, prediction probabilities (Pk), and signal-to-noise ratios of different electroencephalographic parameters during administration of desflurane, isoflurane, and sevoflurane in rats.
Anesthesiology 2008;108(2):276-85.
2008: Helmut Schwilden; Jürgen Schüttler
Target controlled anaesthetic drug dosing.
Handbook of experimental pharmacology 2008;(182):425-50.
2008: Jörg Fechner; Helmut Schwilden; Jürgen Schüttler
Pharmacokinetics and pharmacodynamics of GPI 15715 or fospropofol (Aquavan injection) - a water-soluble propofol prodrug.
Handbook of experimental pharmacology 2008;(182):253-66.
2007: Martin F Fromm; Helmut Schwilden; Iouri Bachmakov; Jörg König; Frank Bremer; Jürgen Schüttler
Impact of the CYP3A5 genotype on midazolam pharmacokinetics and pharmacodynamics during intensive care sedation.
European journal of clinical pharmacology 2007;63(12):1129-33.
2007: Harald Ihmsen; K Naguib; Gerhard Schneider; Helmut Schwilden; Jürgen Schüttler; Eberhard Kochs
Teletherapeutic drug administration by long distance closed-loop control of propofol.
British journal of anaesthesia 2007;98(2):189-95.
2006: Christian Jeleazcov; Gerhard Schneider; Michael Daunderer; Bertram Scheller; Jürgen Schüttler; Helmut Schwilden
The discriminant power of simultaneous monitoring of spontaneous electroencephalogram and evoked potentials as a predictor of different clinical states of general anesthesia.
Anesthesia and analgesia 2006;103(4):894-901.
2006: Harald Ihmsen; Christian Jeleazcov; Jürgen Schüttler; Helmut Schwilden; Frank Bremer
[Pharmacodynamics of two different propofol formulations].
Der Anaesthesist 2006;55(6):635-42.
2006: Helmut Schwilden
Concepts of EEG processing: from power spectrum to bispectrum, fractals, entropies and all that.
Best practice & research. Clinical anaesthesiology 2006;20(1):31-48.
2005: Harald Ihmsen; Michael Schywalsky; A Tzabazis; Helmut Schwilden
Development of acute tolerance to the EEG effect of propofol in rats.
British journal of anaesthesia 2005;95(3):367-71.
2005: Helmut Schwilden; Eberhard Kochs; Michael Daunderer; Christian Jeleazcov; Bertram Scheller; Gerhard Schneider; Jürgen Schüttler; Dierk Schwender; G Stockmanns; Ernst Pöppel
Concurrent recording of AEP, SSEP and EEG parameters during anaesthesia: a factor analysis.
British journal of anaesthesia 2005;95(2):197-206.
2005: Christian Jeleazcov; Jörg Fechner; Helmut Schwilden
Electroencephalogram monitoring during anesthesia with propofol and alfentanil: the impact of second order spectral analysis.
Anesthesia and analgesia 2005;100(5):1365-9, table of contents.
2005: Jörg Fechner; Harald Ihmsen; Christine Schiessl; Christian Jeleazcov; James J Vornov; Helmut Schwilden; Jürgen Schüttler
Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteers.
Anesthesia and analgesia 2005;100(3):701-6, table of contents.
2005: Michael Schywalsky; Harald Ihmsen; Rainer Knoll; Helmut Schwilden
Binding of propofol to human serum albumin.
Arzneimittel-Forschung 2005;55(6):303-6.
2004: Frank Bremer; Udo Reulbach; Helmut Schwilden; Jürgen Schüttler
Midazolam therapeutic drug monitoring in intensive care sedation: a 5-year survey.
Therapeutic drug monitoring 2004;26(6):643-9.
2004: Harald Ihmsen; Christian Jeleazcov; Jürgen Schüttler; Helmut Schwilden; Frank Bremer
[Accuracy of target-controlled infusion (TCI) with 2 different propofol formulations].
Der Anaesthesist 2004;53(10):937-43.
2004: Jörg Fechner; Harald Ihmsen; Dirk Hatterscheid; Christian Jeleazcov; Christine Schiessl; James J Vornov; Helmut Schwilden; Jürgen Schüttler
Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion.
Anesthesiology 2004;101(3):626-39.
2004: Christian Jeleazcov; S Egner; Frank Bremer; Helmut Schwilden
Automated EEG preprocessing during anaesthesia: new aspects using artificial neural networks.
Biomedizinische Technik. Biomedical engineering 2004;49(5):125-31.
2004: Helmut Schwilden
[Volatile anaesthetics are outdated--pro].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 2004;39(4):220-2.
2004: A Tzabazis; Harald Ihmsen; Michael Schywalsky; Helmut Schwilden
EEG-controlled closed-loop dosing of propofol in rats.
British journal of anaesthesia 2004;92(4):564-9.
2004: Harald Ihmsen; Sven Albrecht; Werner Hering; Jürgen Schüttler; Helmut Schwilden
Modelling acute tolerance to the EEG effect of two benzodiazepines.
British journal of clinical pharmacology 2004;57(2):153-61.
2003: Christian Jeleazcov; Helmut Schwilden
[Bispectral analysis does not differentiate between anaesthesia EEG and a linear random process].
Biomedizinische Technik. Biomedical engineering 2003;48(10):269-74.
2003: Jörg Fechner; Harald Ihmsen; Dirk Hatterscheid; Christine Schiessl; James J Vornov; Eric Burak; Helmut Schwilden; Jürgen Schüttler
Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers.
Anesthesiology 2003;99(2):303-13.
2003: Helmut Schwilden; Jörg Fechner; Sven Albrecht; Werner Hering; Harald Ihmsen; Jürgen Schüttler
Testing and modelling the interaction of alfentanil and propofol on the EEG.
European journal of anaesthesiology 2003;20(5):363-72.
2003: Michael Schywalsky; Harald Ihmsen; A Tzabazis; Jörg Fechner; Eric Burak; James J Vornov; Helmut Schwilden
Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats.
European journal of anaesthesiology 2003;20(3):182-90.
2002: Helmut Schwilden; Christian Jeleazcov
Does the EEG during isoflurane/alfentanil anesthesia differ from linear random data?
Journal of clinical monitoring and computing 2002;17(7-8):449-57.
2002: Harald Ihmsen; A Tzabazis; Michael Schywalsky; Helmut Schwilden
Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects.
European journal of anaesthesiology 2002;19(3):177-88.
2001: Helmut Schwilden; Jürgen Schüttler
200 years of nitrous oxide (laughing gas)--and the end of an era?
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 2001;36(10):640.
2001: Jürgen Schüttler; Helmut Schwilden
[200 years of nitrous oxide--at the end of an era?].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 2001;36(10):640.
2001: Thomas M Hemmerling; Jürgen Schuettler; Helmut Schwilden
Desflurane reduces the effective therapeutic infusion rate (ETI) of cisatracurium more than isoflurane, sevoflurane, or propofol.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2001;48(6):532-7.
2000: M St Pierre; B Landsleitner; Helmut Schwilden; Jürgen Schuettler
Awareness during laryngoscopy and intubation: quantitating incidence following induction of balanced anesthesia with etomidate and cisatracurium as detected with the isolated forearm technique.
Journal of clinical anesthesia 2000;12(2):104-8.
1999: Sven Albrecht; Werner Hering; Harald Ihmsen; Helmut Schwilden; Jürgen Schüttler
[Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 1999;34(10):634-7.
1999: Sven Albrecht; Harald Ihmsen; Werner Hering; Gerd Geisslinger; J Dingemanse; Helmut Schwilden; Jürgen Schüttler
The effect of age on the pharmacokinetics and pharmacodynamics of midazolam.
Clinical pharmacology and therapeutics 1999;65(6):630-9.
1999: Jürgen Schüttler; Helmut Schwilden
Present state of closed-loop drug delivery in anesthesia and intensive care.
Acta anaesthesiologica Belgica 1999;50(4):187-91.
1999: Helmut Schwilden; Jürgen Schüttler
Depth of anesthesia: the value of surrogates to measure an unobservable state.
Acta anaesthesiologica Belgica 1999;50(4):177-82.
1998: Jörg Fechner; Sven Albrecht; Harald Ihmsen; Rainer Knoll; Helmut Schwilden; Jürgen Schüttler
[Predictability and precision of "target-controlled infusion" (TCI) of propofol with the "Disoprifusor TCI" system].
Der Anaesthesist 1998;47(8):663-8.
1997: J Dingemanse; J Häussler; Werner Hering; Harald Ihmsen; S Albrecht; M Zell; Helmut Schwilden; Jürgen Schüttler
Pharmacokinetic-pharmacodynamic modelling of the EEG effects of Ro 48-6791, a new short-acting benzodiazepine, in young and elderly subjects.
British journal of anaesthesia 1997;79(5):567-74.
1997: Helmut Schwilden
[Anesthesiology].
Arzneimittel-Forschung 1997;47(10):1172-3.
1996: Werner Hering; Harald Ihmsen; Sven Albrecht; Helmut Schwilden; Jürgen Schüttler
[RO 48-6791--a short acting benzodiazepine. Pharmacokinetics and pharmacodynamics in young and old subjects in comparison to midazolam].
Der Anaesthesist 1996;45(12):1211-4.
1996: Sven Albrecht; Werner Hering; Jürgen Schüttler; Helmut Schwilden
[New intravenous anesthetics. Remifentanil, S(+)-ketamine, eltanolone and target controlled infusion].
Der Anaesthesist 1996;45(12):1129-41.