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Clara Sciorati

Research Profile

Chemicals & Drugs

Physiology

Living Beings

Mouse
Rats

Anatomy

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Publications

TOP 3
Maria Grazia D'Angelo; Sandra Gandossini; Francesca Magri; Filippo Martinelli Boneschi; Clara Sciorati; Giuseppe Stefanoni; Anna Carla Turconi; Sara Bonato; Nereo Bresolin; Erika Brighina; Silvia Brunelli; Dario Cattaneo; Giacomo P Comi; Emilio Clementi
Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients.
Roberta Buono; Emanuele Azzoni; Maria Teresa Bassi; Silvia Brunelli; Viviana Pisa; Clara Sciorati; Chiara Vantaggiato; Emilio Clementi
Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP.
Clara Sciorati; Daniela Miglietta; Viviana Pisa; Emanuele Azzoni; Silvia Brunelli; Roberta Buono; Dario Cattaneo; Emilio Clementi
A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

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All Publications

2012: Maria Grazia D'Angelo; Sandra Gandossini; Francesca Magri; Filippo Martinelli Boneschi; Clara Sciorati; Giuseppe Stefanoni; Anna Carla Turconi; Sara Bonato; Nereo Bresolin; Erika Brighina; Silvia Brunelli; Dario Cattaneo; Giacomo P Comi; Emilio Clementi
Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients.
Pharmacological research : the official journal of the Italian Pharmacological Society 2012;65(4):472-9.
2012: Roberta Buono; Emanuele Azzoni; Maria Teresa Bassi; Silvia Brunelli; Viviana Pisa; Clara Sciorati; Chiara Vantaggiato; Emilio Clementi
Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP.
Stem cells (Dayton, Ohio) 2012;30(2):197-209.
2011: Clara Sciorati; Daniela Miglietta; Viviana Pisa; Emanuele Azzoni; Silvia Brunelli; Roberta Buono; Dario Cattaneo; Emilio Clementi
A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(3):210-7.
2011: Chiara Foglieni; Alessandro Fulgenzi; Clara Sciorati; Daniela Belloni; Elisabetta Ferrero; Maria Elena Ferrero
Ozonated autohemotherapy: protection of kidneys from ischemia in rats subjected to unilateral nephrectomy.
BMC nephrology 2011;12():61.
2010: Paolo Ascenzi; Alessandra di Masi; Clara Sciorati; Emilio Clementi
Peroxynitrite-An ugly biofactor?
BioFactors (Oxford, England) 2010;36(4):264-73.
2010: Clara Sciorati; Roberta Buono; Emanuele Azzoni; Silvana Casati; Pierangela Ciuffreda; Grazia D'Angelo; Dario Cattaneo; Silvia Brunelli; Emilio Clementi
Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans.
British journal of pharmacology 2010;160(6):1550-60.
2009: Clara Sciorati; Thierry Touvier; Roberta Buono; Patrizia Pessina; Stephanie François; Cristiana Perrotta; Raffaella Meneveri; Emilio Clementi; Silvia Brunelli
Necdin is expressed in cachectic skeletal muscle to protect fibers from tumor-induced wasting.
Journal of cell science 2009;122(Pt 8):1119-25.
2008: Raffaella Scardigli; Cesare Gargioli; Daniela Tosoni; Ugo Borello; Maurilio Sampaolesi; Clara Sciorati; Stefano Cannata; Emilio Clementi; Silvia Brunelli; Giulio Cossu
Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules.
PloS one 2008;3(6):e2471.
2007: Daniela Deponti; Stéphanie François; Silvia Baesso; Clara Sciorati; Anna Innocenzi; Vania Broccoli; Françoise Muscatelli; Raffaella Meneveri; Emilio Clementi; Giulio Cossu; Silvia Brunelli
Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.
The Journal of cell biology 2007;179(2):305-19.
2007: Silvia Brunelli; Clara Sciorati; Giuseppe D'Antona; Anna Innocenzi; Diego Covarello; Beatriz G Galvez; Cristiana Perrotta; Angela Monopoli; Francesca Sanvito; Roberto Bottinelli; Ennio Ongini; Giulio Cossu; Emilio Clementi
Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):264-9.
2007: Silvia Brunelli; Patrizia Rovere-Querini; Clara Sciorati; angelo manfredi; Emilio Clementi
Nitric oxide: emerging concepts about its use in cell-based therapies.
Expert opinion on investigational drugs 2007;16(1):33-43.
2006: Clara Sciorati; Beatriz G Galvez; Silvia Brunelli; Enrico Tagliafico; Stefano Ferrari; Giulio Cossu; Emilio Clementi
Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy.
Journal of cell science 2006;119(Pt 24):5114-23.
2006: Andrea Guidarelli; Clara Sciorati; Emilio Clementi; Orazio Cantoni
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA.
Free radical biology & medicine 2006;41(1):154-64.
2006: Chiara Foglieni; Alessandro Fulgenzi; Paolo Ticozzi; Fabio Pellegatta; Clara Sciorati; Daniela Belloni; Elisabetta Ferrero; Maria Elena Ferrero
Protective effect of EDTA preadministration on renal ischemia.
BMC nephrology 2006;7():5.
2005: Cristiana Perrotta; Clara De Palma; sestina Falcone; Clara Sciorati; Emilio Clementi
Nitric oxide, ceramide and sphingomyelinase-coupled receptors: a tale of enzymes and messengers coordinating cell death, survival and differentiation.
Life sciences 2005;77(14):1732-9.
2005: Stefania Girlanda; Claudio Fortis; Daniela Belloni; Elisabetta Ferrero; Paolo Ticozzi; Clara Sciorati; Moreno Tresoldi; Aurelio Vicari; Thomas Spies; Veronika Groh; Federico Caligaris-Cappio; Manlio Ferrarini
MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes.
Cancer research 2005;65(16):7502-8.
2004: sestina Falcone; Cristiana Perrotta; Clara De Palma; Addolorata Pisconti; Clara Sciorati; Annalisa Capobianco; Patrizia Rovere-Querini; angelo manfredi; Emilio Clementi
Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4452-63.
2004: Cristiana Perrotta; sestina Falcone; Annalisa Capobianco; Annalisa Camporeale; Clara Sciorati; Clara De Palma; Addolorata Pisconti; Patrizia Rovere-Querini; Matteo Bellone; angelo manfredi; Emilio Clementi
Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma.
Cancer research 2004;64(11):3767-71.
2003: Enzo Nisoli; Emilio Clementi; Clara Paolucci; Valeria Cozzi; Cristina Tonello; Clara Sciorati; Renata Bracale; Alessandra Valerio; Maura Francolini; Salvador Moncada; Michele O Carruba
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
Science (New York, N.Y.) 2003;299(5608):896-9.
2002: sestina Falcone; Loredana Mauro; Giacinta de Rose; Clara Paolucci; Clara Sciorati; Sebastiano Ando; Emilio Clementi
Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1.
The Biochemical journal 2002;366(Pt 1):165-73.
2002: Marilena Campanella; Clara Sciorati; Glauco Tarozzo; Massimiliano Beltramo
Flow cytometric analysis of inflammatory cells in ischemic rat brain.
Stroke; a journal of cerebral circulation 2002;33(2):586-92.
2001: Manlio Ferrarini; Giuseppe Consogno; Patrizia Rovere-Querini; Clara Sciorati; Lorenzo Dagna; D Resta; Claudio Rugarli; angelo manfredi
Inhibition of caspases maintains the antineoplastic function of gammadelta T cells repeatedly challenged with lymphoma cells.
Cancer research 2001;61(7):3092-5.
2001: Angelo Quattrini; Isabella Lorenzetti; Clara Sciorati; Massimo Corbo; Stefano C Previtali; M Laura Feltri; Nicola Canal; Lawrence Wrabetz; Raffaello Nemni; Emilio Clementi
Human IgM anti-GM1 autoantibodies modulate intracellular calcium homeostasis in neuroblastoma cells.
Journal of neuroimmunology 2001;114(1-2):213-9.
2000: Letizia Palomba; Piero Sestili; Andrea Guidarelli; Clara Sciorati; Emilio Clementi; Mara Fiorani; Orazio Cantoni
Products of the phospholipase A(2) pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells.
Free radical biology & medicine 2000;29(8):783-9.
2000: Jacopo Meldolesi; Clara Sciorati; Emilio Clementi
The p75 receptor: first insights into the transduction mechanisms leading to either cell death or survival.
Trends in pharmacological sciences 2000;21(7):242-3.
2000: M Rabuffetti; Clara Sciorati; Glauco Tarozzo; Emilio Clementi; angelo manfredi; Massimiliano Beltramo
Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(12):4398-404.
2000: Dorotea Rigamonti; Johannes Bauer; C De Fraja; Luciano Conti; Simonetta Sipione; Clara Sciorati; Emilio Clementi; Abigail S Hackam; Michael R Hayden; Yun Li; J K Cooper; Christopher A Ross; Stefano Govoni; Claudius Vincenz; Elena Cattaneo
Wild-type huntingtin protects from apoptosis upstream of caspase-3.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3705-13.
2000: C De Nadai; Piero Sestili; Orazio Cantoni; JP Lièvremont; Clara Sciorati; Rico Barsacchi; Salvador Moncada; Jacopo Meldolesi; Emilio Clementi
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5480-5.
2000: Piero Sestili; Emilio Clementi; Andrea Guidarelli; Clara Sciorati; Orazio Cantoni
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively.
The European journal of neuroscience 2000;12(1):145-54.
1999: Andrea Guidarelli; Emilio Clementi; Clara Sciorati; Orazio Cantoni
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells.
Journal of neurochemistry 1999;73(4):1667-73.
1999: Clara Sciorati; Patrizia Rovere-Querini; Manlio Ferrarini; Clara Paolucci; S Heltai; R Vaiani; Emilio Clementi; angelo manfredi
Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1570-6.
1999: JP Lièvremont; Clara Sciorati; Eugenio Morandi; Clara Paolucci; G Bunone; G Della Valle; Jacopo Meldolesi; Emilio Clementi
The p75(NTR)-induced apoptotic program develops through a ceramide-caspase pathway negatively regulated by nitric oxide.
The Journal of biological chemistry 1999;274(22):15466-72.
1999: Manlio Ferrarini; MA Imro; Clara Sciorati; S Heltai; Maria Pia Protti; C Pellicciari; Patrizia Rovere-Querini; angelo manfredi; Claudio Rugarli
Blockade of the Fas-triggered intracellular signaling pathway in human melanomas is circumvented by cytotoxic lymphocytes.
International journal of cancer. Journal international du cancer 1999;81(4):573-9.
1998: Andrea Guidarelli; Emilio Clementi; Clara Sciorati; Orazio Cantoni
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage.
British journal of pharmacology 1998;125(5):1074-80.
1998: Enzo Nisoli; Emilio Clementi; Cristina Tonello; Clara Sciorati; Luca Briscini; Michele O Carruba
Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures.
British journal of pharmacology 1998;125(4):888-94.
1998: angelo manfredi; S Heltai; Patrizia Rovere-Querini; Clara Sciorati; Clara Paolucci; Giovanni Galati; Claudio Rugarli; R Vaiani; Emilio Clementi; Manlio Ferrarini
Mycobacterium tuberculosis exploits the CD95/CD95 ligand system of gammadelta T cells to cause apoptosis.
European journal of immunology 1998;28(6):1798-806.
1997: Andrea Guidarelli; L Brambilla; Emilio Clementi; Clara Sciorati; Orazio Cantoni
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks.
Experimental cell research 1997;237(1):176-85.
1997: Clara Sciorati; G Nisticò; Jacopo Meldolesi; Emilio Clementi
Nitric oxide effects on cell growth: GMP-dependent stimulation of the AP-1 transcription complex and cyclic GMP-independent slowing of cell cycling.
British journal of pharmacology 1997;122(4):687-97.
1997: Andrea Guidarelli; Emilio Clementi; Clara Sciorati; Flaminio Nicola Cattabeni; Orazio Cantoni
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide.
The Journal of pharmacology and experimental therapeutics 1997;283(1):66-74.
1997: Clara Sciorati; Patrizia Rovere-Querini; Manlio Ferrarini; S Heltai; angelo manfredi; Emilio Clementi
Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes.
The Journal of biological chemistry 1997;272(37):23211-5.
1996: Emilio Clementi; M Riccio; Clara Sciorati; G Nisticò; Jacopo Meldolesi
The type 2 ryanodine receptor of neurosecretory PC12 cells is activated by cyclic ADP-ribose. Role of the nitric oxide/cGMP pathway.
The Journal of biological chemistry 1996;271(30):17739-45.
1996: Patrizia Rovere-Querini; Emilio Clementi; Manlio Ferrarini; S Heltai; Clara Sciorati; Maria Grazia Sabbadini; Claudio Rugarli; angelo manfredi
CD95 engagement releases calcium from intracellular stores of long term activated, apoptosis-prone gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4631-7.
1995: Emilio Clementi; Clara Sciorati; G Nisticò
Growth factor-induced Ca2+ responses are differentially modulated by nitric oxide via activation of a cyclic GMP-dependent pathway.
Molecular pharmacology 1995;48(6):1068-77.
1995: Emilio Clementi; Clara Sciorati; M Riccio; M Miloso; Jacopo Meldolesi; G Nisticò
Nitric oxide action on growth factor-elicited signals. Phosphoinositide hydrolysis and [Ca2+]i responses are negatively modulated via a cGMP-dependent protein kinase I pathway.
The Journal of biological chemistry 1995;270(38):22277-82.
1995: Emilio Clementi; I Vecchio; Clara Sciorati; G Nisticò
Nitric oxide modulation of agonist-evoked intracellular Ca2+ release in neurosecretory PC-12 cells: inhibition of phospholipase C activity via cyclic GMP-dependent protein kinase I.
Molecular pharmacology 1995;47(3):517-24.