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Giorgio Scita

Research Profile

Chemicals & Drugs

Physiology

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Protein Binding

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Protein Structure, Tertiary

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Achim Werner; Janina Becker; Matthew Calabrese; Andrea Disanza; Gregor Habeck; Holger Lorenz; Nina Reifenberger; Brenda Schulman; Giorgio Scita; Henning Urlaub; Frauke Melchior
SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.
Romina M Wiedmann; Stefan Zahler; Karin von Schwarzenberg; Ernst Wagner; Rebekka Kubisch; Johanna Liebl; Rolf Müller; Andrea Palamidessi; Christina Schempp; Laura Schreiner; Giorgio Scita; Dirk Trauner; Gyorgy Vereb; Angelika M Vollmar
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Arianna Crespi; Andrea Disanza; Ilaria Ferrari; Diego Fornasari; Paola Lonati; Valeria Padovano; Giorgio Scita; Grazia Pietrini
LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.

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All Publications

2013: Achim Werner; Janina Becker; Matthew Calabrese; Andrea Disanza; Gregor Habeck; Holger Lorenz; Nina Reifenberger; Brenda Schulman; Giorgio Scita; Henning Urlaub; Frauke Melchior
SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.
Nature cell biology 2013;15(2):179-88.
2012: Romina M Wiedmann; Stefan Zahler; Karin von Schwarzenberg; Ernst Wagner; Rebekka Kubisch; Johanna Liebl; Rolf Müller; Andrea Palamidessi; Christina Schempp; Laura Schreiner; Giorgio Scita; Dirk Trauner; Gyorgy Vereb; Angelika M Vollmar
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Cancer research 2012;72(22):5976-87.
2012: Arianna Crespi; Andrea Disanza; Ilaria Ferrari; Diego Fornasari; Paola Lonati; Valeria Padovano; Giorgio Scita; Grazia Pietrini
LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.
Journal of cell science 2012;125(Pt 19):4543-54.
2012: Sara Sigismund; Andrea Ciliberto; Stefano Confalonieri; Simona Polo; Giorgio Scita; Pier Paolo Di Fiore
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.
Physiological reviews 2012;92(1):273-366.
2011: Elisabetta Menna; Giorgio Scita; Giuliana Fossati; Michela Matteoli
From filopodia to synapses: the role of actin-capping and anti-capping proteins.
The European journal of neuroscience 2011;34(10):1655-62.
2011: Emanuela Frittoli; Luigi Maddaluno; Gianluca Matteoli; Elisa Mazzini; Andrea Palamidessi; Maria Rescigno; Tatyana M Svitkina; Changsong Yang; Andrea Disanza; Giorgio Scita
The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.
Immunity 2011;35(3):388-99.
2011: Federico Vaggi; Pier Paolo Di Fiore; Andrea Disanza; Nir S Gov; Michela Matteoli; Elisabetta Menna; Francesca Milanesi; Giorgio Scita; Andrea Ciliberto
The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation.
PLoS computational biology 2011;7(7):e1002088.
2011: Angela De Laurentiis; Olivier E Pardo; Andrea Palamidessi; Shaun P Jackson; Simone M Schoenwaelder; Ernst Reichmann; Giorgio Scita; Alexandre Arcaro
The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.
Cellular signalling 2011;23(3):529-41.
2011: Emanuela Frittoli; Andrea Palamidessi; Andrea Disanza; Giorgio Scita
Secretory and endo/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm.
European journal of cell biology 2011;90(2-3):108-14.
2011: Uri Manor; Andrea Disanza; M'hamed Grati; Leonardo Andrade; Harrison Lin; Pier Paolo Di Fiore; Giorgio Scita; Anne E White-Olson
Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
Current biology : CB 2011;21(2):167-72.
2011: Barak Peleg; Andrea Disanza; Giorgio Scita; Nir S Gov
Propagating cell-membrane waves driven by curved activators of actin polymerization.
PloS one 2011;6(4):e18635.
2010: Thilo Welsch; Alexander Younsi; Andrea Disanza; Jose Antonio Rodriguez; Ana Maria Cuervo; Giorgio Scita; Jan Schmidt
Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells.
Experimental cell research 2010;316(12):1914-24.
2010: A Palamidessi; I Testa; Emanuela Frittoli; S Barozzi; M Garrè; Davide Mazza; Pier Paolo Di Fiore; Alberto Diaspro; Giorgio Scita; Mario Faretta
Understanding biological dynamics: following cells and molecules to track functions and mechanisms.
European biophysics journal : EBJ 2010;39(6):947-57.
2010: Giorgio Scita; Pier Paolo Di Fiore
The endocytic matrix.
Nature 2010;463(7280):464-73.
2010: Maud Hertzog; Francesca Milanesi; Larnele Hazelwood; Andrea Disanza; HongJun Liu; Emilie Perlade; Maria Grazia Malabarba; Sebastiano Pasqualato; Alessio Maiolica; Stefano Confalonieri; Christophe Le Clainche; Nina Offenhauser; Jennifer Block; Klemens Rottner; Pier Paolo Di Fiore; Marie-France Carlier; Niels Volkmann; Dorit Hanein; Giorgio Scita
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.
PLoS biology 2010;8(6):e1000387.
2010: Arianna Tocchetti; Charlotte Blanche Ekalle Soppo; Fabio Zani; Fabrizio Bianchi; Maria Cristina Gagliani; Benedetta Pozzi; Jan Rozman; Ralf Elvert; Nicole Ehrhardt; Birgit Rathkolb; Corinna Moerth; Marion Horsch; Helmut Fuchs; Valérie Gailus-Durner; Johannes Beckers; Martin Klingenspor; Eckhard Wolf; Martin Hrabé de Angelis; Eugenio Scanziani; Carlo Tacchetti; Giorgio Scita; Pier Paolo Di Fiore; Nina Offenhäuser
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PloS one 2010;5(3):e9468.
2009: Bharesh K Chauhan; Andrea Disanza; Sue-Yeon Choi; Sonya C Faber; Ming Lou; Hilary E Beggs; Giorgio Scita; Yi Zheng; Richard Lang
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.
Development (Cambridge, England) 2009;136(21):3657-67.
2009: Jinghui Hu; Flavia Troglio; Alka Mukhopadhyay; Stephanie Everingham; Ester Kwok; Giorgio Scita; Andrew W B Craig
F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation.
Cellular signalling 2009;21(11):1686-97.
2009: Chiara Giuliani; Flavia Troglio; Zhiyong Bai; Falshruti B Patel; Adriana Zucconi; Maria Grazia Malabarba; Andrea Disanza; Theresia B Stradal; giuseppe cassata; Stefano Confalonieri; Jeffrey D Hardin; Martha C Soto; Barth D Grant; Giorgio Scita
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
PLoS genetics 2009;5(10):e1000675.
2009: Andrea Disanza; Emanuela Frittoli; Andrea Palamidessi; Giorgio Scita
Endocytosis and spatial restriction of cell signaling.
Molecular oncology 2009;3(4):280-96.
2009: Carmelo Ferrai; Gabriela Naum-Onganía; Elena Longobardi; Martina Palazzolo; Andrea Disanza; Victor M Diaz; Massimo P Crippa; Giorgio Scita; Francesco Blasi
Induction of HoxB transcription by retinoic acid requires actin polymerization.
Molecular biology of the cell 2009;20(15):3543-51.
2009: Elisabetta Menna; Andrea Disanza; Cinzia Cagnoli; Ursula Schenk; Giuliana Gelsomino; Emanuela Frittoli; Maud Hertzog; Nina Offenhauser; Corinna Sawallisch; Hans-Jürgen Kreienkamp; Frank B Gertler; Pier Paolo Di Fiore; Giorgio Scita; Michela Matteoli
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).
PLoS biology 2009;7(6):e1000138.
2009: Corinna Sawallisch; Kerstin Berhörster; Andrea Disanza; Sara Mantoani; Michael Kintscher; Luminita Stoenica; Alexander Dityatev; Sabrina Sieber; Stefan Kindler; Fabio Morellini; Michaela Schweizer; Tobias M Boeckers; Martin Korte; Giorgio Scita; Hans-Jürgen Kreienkamp
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
The Journal of biological chemistry 2009;284(14):9225-36.
2009: Stefanie M Weiss; Markus Ladwein; Dorothea Schmidt; Julia Ehinger; Silvia Lommel; Kai Städing; Ulrike Beutling; Andrea Disanza; Ronald Frank; Lothar Jänsch; Giorgio Scita; Florian Gunzer; Klemens Rottner; Theresia E B Stradal
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.
Cell host & microbe 2009;5(3):244-58.
2009: Changsong Yang; Matthew Hoelzle; Andrea Disanza; Giorgio Scita; Tatyana M Svitkina
Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion.
PloS one 2009;4(5):e5678.
2008: Andrea Disanza; Giorgio Scita
Cytoskeletal regulation: coordinating actin and microtubule dynamics in membrane trafficking.
Current biology : CB 2008;18(18):R873-5.
2008: Andrea Palamidessi; Emanuela Frittoli; Massimiliano Garré; Mario Faretta; Marina Mione; Ilaria Testa; Alberto Diaspro; Letizia Lanzetti; Giorgio Scita; Pier Paolo Di Fiore
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.
Cell 2008;134(1):135-47.
2008: Emanuela Frittoli; Andrea Palamidessi; Alessandro Pizzigoni; Letizia Lanzetti; Massimiliano Garrè; Flavia Troglio; Albino Troilo; Mitsunori Fukuda; Pier Paolo Di Fiore; Giorgio Scita; Stefano Confalonieri
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway.
Molecular biology of the cell 2008;19(4):1304-16.
2008: Giorgio Scita; Stefano Confalonieri; Pekka Lappalainen; Shiro Suetsugu
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.
Trends in cell biology 2008;18(2):52-60.
2007: Changsong Yang; Lubov Czech; Silke Gerboth; Shin-ichiro Kojima; Giorgio Scita; Tatyana M Svitkina
Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.
PLoS biology 2007;5(11):e317.
2007: Tanja Bosse; Julia Ehinger; Aleksandra Czuchra; Stefanie Benesch; Anika Steffen; Xunwei Wu; Kathrin Schloen; Hartmut H Niemann; Giorgio Scita; Theresia E B Stradal; Cord Brakebusch; Klemens Rottner
Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.
Molecular and cellular biology 2007;27(19):6615-28.
2006: Takushi Miyoshi; Takahiro Tsuji; Chiharu Higashida; Maud Hertzog; Akiko Fujita; Shuh Narumiya; Giorgio Scita; Naoki Watanabe
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing.
The Journal of cell biology 2006;175(6):947-55.
2006: Andrea Disanza; Sara Mantoani; Maud Hertzog; Silke Gerboth; Emanuela Frittoli; Anika Steffen; Kerstin Berhoerster; Hans-Jürgen Kreienkamp; Francesca Milanesi; Pier Paolo Di Fiore; Andrea Ciliberto; Theresia E B Stradal; Giorgio Scita
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.
Nature cell biology 2006;8(12):1337-47.
2006: Nina Offenhäuser; Daniela Castelletti; Lisa Mapelli; Blanche Ekalle Soppo; Maria Cristina Regondi; Paola Rossi; Egidio D'Angelo; Carolina Frassoni; Alida Amadeo; Arianna Tocchetti; Benedetta Pozzi; Andrea Disanza; Douglas Guarnieri; Christer Betsholtz; Giorgio Scita; Ulrike Heberlein; Pier Paolo Di Fiore
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
Cell 2006;127(1):213-26.
2006: Roy M Katso; Olivier E Pardo; Andrea Palamidessi; Clemens M Franz; Marin Marinov; Angela De Laurentiis; Julian Downward; Giorgio Scita; Anne J Ridley; Michael D Waterfield; Alexandre Arcaro
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.
Molecular biology of the cell 2006;17(9):3729-44.
2006: Silvia Goicoechea; Daniel Arneman; Andrea Disanza; Rafael Garcia-Mata; Giorgio Scita; Carol A Otey
Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells.
Journal of cell science 2006;119(Pt 16):3316-24.
2006: Firdous A Khanday; Lakshmi Santhanam; Kenji Kasuno; Tohru Yamamori; Asma Naqvi; Jeremy Dericco; Artem Bugayenko; Ilwola Mattagajasingh; Andrea Disanza; Giorgio Scita; Kaikobad Irani
Sos-mediated activation of rac1 by p66shc.
The Journal of cell biology 2006;172(6):817-22.
2006: Theresia E B Stradal; Giorgio Scita
Protein complexes regulating Arp2/3-mediated actin assembly.
Current opinion in cell biology 2006;18(1):4-10.
2005: Metello Innocenti; Silke Gerboth; Klemens Rottner; Frank P L Lai; Maud Hertzog; Theresia E B Stradal; Emanuela Frittoli; Dominique Didry; Simona Polo; Andrea Disanza; Stefanie Benesch; Pier Paolo Di Fiore; Marie-France Carlier; Giorgio Scita
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.
Nature cell biology 2005;7(10):969-76.
2005: Jing Shi; Giorgio Scita; James E Casanova
WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium.
The Journal of biological chemistry 2005;280(33):29849-55.
2005: Andrea Disanza; Anika Steffen; Maud Hertzog; Emanuela Frittoli; Klemens Rottner; Giorgio Scita
Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement.
Cellular and molecular life sciences : CMLS 2005;62(9):955-70.
2005: Helene bierne; Hiroaki Miki; Metello Innocenti; Giorgio Scita; Frank B Gertler; Tadaomi Takenawa; Pascale Cossart
WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor.
Journal of cell science 2005;118(Pt 7):1537-47.
2004: Assunta Croce; giuseppe cassata; Andrea Disanza; Maria Cristina Gagliani; Carlo Tacchetti; Maria Grazia Malabarba; Marie-France Carlier; Giorgio Scita; Ralf Baumeister; Pier Paolo Di Fiore
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
Nature cell biology 2004;6(12):1173-9.
2004: Andrea Disanza; Marie-France Carlier; Theresia E B Stradal; Dominique Didry; Emanuela Frittoli; Stefano Confalonieri; Assunta Croce; Jürgen Wehland; Pier Paolo Di Fiore; Giorgio Scita
Eps8 controls actin-based motility by capping the barbed ends of actin filaments.
Nature cell biology 2004;6(12):1180-8.
2004: Theresia E B Stradal; Klemens Rottner; Andrea Disanza; Stefano Confalonieri; Metello Innocenti; Giorgio Scita
Regulation of actin dynamics by WASP and WAVE family proteins.
Trends in cell biology 2004;14(6):303-11.
2004: Letizia Lanzetti; Andrea Palamidessi; Liliana B Areces; Giorgio Scita; Pier Paolo Di Fiore
Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases.
Nature 2004;429(6989):309-14.
2004: Metello Innocenti; Adriana Zucconi; Andrea Disanza; Emanuela Frittoli; Liliana B Areces; Anika Steffen; Theresia E B Stradal; Pier Paolo Di Fiore; Marie-France Carlier; Giorgio Scita
Abi1 is essential for the formation and activation of a WAVE2 signalling complex.
Nature cell biology 2004;6(4):319-27.
2004: Patrizia Sini; Angela Cannas; Anthony J Koleske; Pier Paolo Di Fiore; Giorgio Scita
Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation.
Nature cell biology 2004;6(3):268-74.
2004: Anika Steffen; Klemens Rottner; Julia Ehinger; Metello Innocenti; Giorgio Scita; Jürgen Wehland; Theresia E B Stradal
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.
The EMBO journal 2004;23(4):749-59.
2004: Nina Offenhäuser; Alessandro Borgonovo; Andrea Disanza; Pascale Romano; Isabella Ponzanelli; Gioacchin Iannolo; Pier Paolo Di Fiore; Giorgio Scita
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.
Molecular biology of the cell 2004;15(1):91-8.
2003: Arianna Tocchetti; Stefano Confalonieri; Giorgio Scita; Pier Paolo Di Fiore; Christer Betsholtz
In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.
Genomics 2003;81(2):234-44.
2003: Metello Innocenti; Emanuela Frittoli; Isabella Ponzanelli; John R Falck; Saskia M Brachmann; Pier Paolo Di Fiore; Giorgio Scita
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.
The Journal of cell biology 2003;160(1):17-23.
2002: Filiberto Belli; Alessandro Testori; Licia Rivoltini; Michele Maio; Giovanna Andreola; Mario Roberto Sertoli; Gianfrancesco Gallino; Adriano Piris; Alessandro Cattelan; Ivano Lazzari; Matteo Carrabba; Giorgio Scita; Cristina Santantonio; Lorenzo Pilla; Gabrina Tragni; Claudia Lombardo; Flavio Arienti; Alfonso Marchianò; Paola Queirolo; Francesco Bertolini; Agata Cova; Elda Lamaj; Lucio Ascani; Roberto Camerini; Marco Corsi; Natale Cascinelli; Jonathan J Lewis; Pramod Srivastava; Giorgio Parmiani
Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(20):4169-80.
2002: Pier Paolo Di Fiore; Giorgio Scita
Eps8 in the midst of GTPases.
The international journal of biochemistry & cell biology 2002;34(10):1178-83.
2002: Metello Innocenti; Pierluigi Tenca; Emanuela Frittoli; Mario Faretta; Arianna Tocchetti; Pier Paolo Di Fiore; Giorgio Scita
Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.
The Journal of cell biology 2002;156(1):125-36.
2001: Letizia Lanzetti; Pier Paolo Di Fiore; Giorgio Scita
Pathways linking endocytosis and actin cytoskeleton in mammalian cells.
Experimental cell research 2001;271(1):45-56.
2001: Giorgio Scita; Pierluigi Tenca; Liliana B Areces; Arianna Tocchetti; Emanuela Frittoli; Giuseppina Giardina; Isabella Ponzanelli; P Sini; Metello Innocenti; Pier Paolo Di Fiore
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.
The Journal of cell biology 2001;154(5):1031-44.
2000: Letizia Lanzetti; Vladimir Rybin; Maria Grazia Malabarba; Savvas Christoforidis; Giorgio Scita; Marino Zerial; Pier Paolo Di Fiore
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Nature 2000;408(6810):374-7.
2000: Giorgio Scita; Pierluigi Tenca; Emanuela Frittoli; Arianna Tocchetti; Metello Innocenti; Giuseppina Giardina; Pier Paolo Di Fiore
Signaling from Ras to Rac and beyond: not just a matter of GEFs.
The EMBO journal 2000;19(11):2393-8.
1999: Giorgio Scita; J Nordstrom; Roberta Carbone; Pierluigi Tenca; Giuseppina Giardina; J Silvio Gutkind; Mattias Bjarnegård; Christer Betsholtz; Pier Paolo Di Fiore
EPS8 and E3B1 transduce signals from Ras to Rac.
Nature 1999;401(6750):290-3.