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Matthew Scott

Research Profile

Chemicals & Drugs

Physiology

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Mouse

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Tom A Hartl; Arlen W Johnson; Daniel D Kaplan; Julie Ni; Stephanie Patchett; Cyril Bussiere; Jian Cao; Matthew Fish; Dan Yi Gui; Kaye L Suyama; Sheng Tang; Matthew P Scott
Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila.
Alyssa C Snider; Q Tian Wang; Joanna Wysocka; Mylene W M Yao; Denise Leong; Matthew P Scott
The chromatin remodeling factor Chd1l is required in the preimplantation embryo.
Eszter Vladar; Roy D Bayly; Ashvin M Sangoram; Matthew P Scott; Jeffrey D Axelrod
Microtubules enable the planar cell polarity of airway cilia.

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All Publications

2013: Tom A Hartl; Arlen W Johnson; Daniel D Kaplan; Julie Ni; Stephanie Patchett; Cyril Bussiere; Jian Cao; Matthew Fish; Dan Yi Gui; Kaye L Suyama; Sheng Tang; Matthew P Scott
Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila.
Genetics 2013;194(1):101-15.
2013: Alyssa C Snider; Q Tian Wang; Joanna Wysocka; Mylene W M Yao; Denise Leong; Matthew P Scott
The chromatin remodeling factor Chd1l is required in the preimplantation embryo.
Biology open 2013;2(2):121-31.
2012: Eszter Vladar; Roy D Bayly; Ashvin M Sangoram; Matthew P Scott; Jeffrey D Axelrod
Microtubules enable the planar cell polarity of airway cilia.
Current biology : CB 2012;22(23):2203-12.
2012: Mili Jeon; Matthew P Scott; Kai Zinn
Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila.
Biology open 2012;1(6):548-58.
2012: Manuel E Lopez; Andres D Klein; Matthew P Scott
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C.
Journal of neuroinflammation 2012;9():216.
2011: Dadi Jiang; Thomas M Johnson; Eunice Y Lee; Eunice J Park; Matthew P Scott; Colleen A Brady; Laura D Attardi
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17123-8.
2011: Manuel E Lopez; Andres D Klein; Ubah J Dimbil; Matthew P Scott
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(12):4367-78.
2010: Monique T Barakat; Eric W Humke; Matthew P Scott
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.
Trends in molecular medicine 2010;16(8):337-48.
2010: Qicong Hu; Ljiljana Milenkovic; Hua Jin; Matthew P Scott; Maxence V Nachury; Elias T Spiliotis; W James Nelson
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.
Science (New York, N.Y.) 2010;329(5990):436-9.
2010: Eunice Y Lee; Hongkai Ji; Zhengqing Ouyang; Baiyu Zhou; Wenxiu Ma; Steven A Vokes; Andrew P McMahon; Wing H Wong; Matthew P Scott
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9736-41.
2010: Eric W Humke; Karolin V Dorn; Ljiljana Milenkovic; Matthew P Scott; Rajat Rohatgi
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Genes & development 2010;24(7):670-82.
2010: Ljiljana Milenkovic; Matthew P Scott
Not lost in space: trafficking in the hedgehog signaling pathway.
Science signaling 2010;3(117):pe14.
2010: Dragana Antic; Jennifer L Stubbs; Kaye Suyama; Chris Kintner; Matthew P Scott; Jeffrey D Axelrod
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.
PloS one 2010;5(2):e8999.
2009: Ljiljana Milenkovic; Matthew P Scott; Rajat Rohatgi
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium.
The Journal of cell biology 2009;187(3):365-74.
2009: Monique T Barakat; Matthew P Scott
Tail wags dog: primary cilia and tumorigenesis.
Cancer cell 2009;16(4):276-7.
2009: Jun Zhang; Marko Fonovic; Kaye Suyama; Matthew Bogyo; Matthew P Scott
Rab35 controls actin bundling by recruiting fascin as an effector protein.
Science (New York, N.Y.) 2009;325(5945):1250-4.
2009: Rajat Rohatgi; Ljiljana Milenkovic; Ryan B Corcoran; Matthew P Scott
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3196-201.
2009: Gregor Zimmermann; Li-Ping Wang; Alexander G Vaughan; Devanand S Manoli; Feng Zhang; Karl Deisseroth; Bruce S Baker; Matthew P Scott
Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response.
PloS one 2009;4(4):e5100.
2008: Ryan B Corcoran; Tal Bachar Raveh; Monique T Barakat; Eunice Y Lee; Matthew P Scott
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice.
Cancer research 2008;68(21):8788-95.
2008: Daniel D Kaplan; Gregor Zimmermann; Kaye Suyama; Tobias Meyer; Matthew P Scott
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size.
Genes & development 2008;22(14):1877-93.
2007: Xun Huang; James T Warren; Joann Buchanan; Lawrence I Gilbert; Matthew P Scott
Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease.
Development (Cambridge, England) 2007;134(20):3733-42.
2007: Rajat Rohatgi; Matthew P Scott
Patching the gaps in Hedgehog signalling.
Nature cell biology 2007;9(9):1005-9.
2007: Rajat Rohatgi; Ljiljana Milenkovic; Matthew P Scott
Patched1 regulates hedgehog signaling at the primary cilium.
Science (New York, N.Y.) 2007;317(5836):372-6.
2007: Matthew P Scott
Developmental genomics of the most dangerous animal.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):11865-6.
2007: Jun Zhang; Karen L Schulze; P Robin Hiesinger; Kaye Suyama; Stream Wang; Matthew Fish; Melih Acar; Roger A Hoskins; Hugo J Bellen; Matthew P Scott
Thirty-one flavors of Drosophila rab proteins.
Genetics 2007;176(2):1307-22.
2007: Michael Deans; Dragana Antic; Kaye Suyama; Matthew P Scott; Jeffrey D Axelrod; Lisa V Goodrich
Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(12):3139-47.
2006: Gregor Zimmermann; Eileen E M Furlong; Kaye Suyama; Matthew P Scott
Mes2, a MADF-containing transcription factor essential for Drosophila development.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(12):3387-95.
2006: Stefan Zappe; Matthew Fish; Matthew P Scott; Olav Solgaard
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens.
Lab on a chip 2006;6(8):1012-9.
2006: Ryan B Corcoran; Matthew P Scott
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8408-13.
2005: Xun Huang; Kaye Suyama; Joann Buchanan; Alan J Zhu; Matthew P Scott
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis.
Development (Cambridge, England) 2005;132(22):5115-24.
2005: Dennis C Ko; Ljiljana Milenkovic; Steven M Beier; Hermogenes Manuel; JoAnn Buchanan; Matthew P Scott
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease.
PLoS genetics 2005;1(1):81-95.
2005: Karen S Ho; Kaye Suyama; Matthew Fish; Matthew P Scott
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused.
Development (Cambridge, England) 2005;132(6):1401-12.
2004: Alan Jian Zhu; Matthew P Scott
Incredible journey: how do developmental signals travel through tissue?
Genes & development 2004;18(24):2985-97.
2004: Matthew P Scott; Peter A Lawrence
Obituary: Edward B. Lewis (1918-2004).
Nature 2004;431(7005):143.
2004: Lara S Collier; Kaye Suyama; Joseph H Anderson; Matthew P Scott
Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling.
Genetics 2004;167(2):783-96.
2004: Qun-Tian T Wang; Karolina Piotrowska; Maria Anna Ciemerych; Ljiljana Milenkovic; Matthew P Scott; Ronald W Davis; Magdalena Zernicka-Goetz
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.
Developmental cell 2004;6(1):133-44.
2003: Aurélie Grienenberger; Samir Merabet; John Manak; Isabelle Iltis; Aurélie Fabre; Hélène Bérenger; Matthew P Scott; Jacques Pradel; Yacine Graba
Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function.
Development (Cambridge, England) 2003;130(22):5445-55.
2003: Alan Jian Zhu; Limin Zheng; Kaye Suyama; Matthew P Scott
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.
Genes & development 2003;17(10):1240-52.
2003: Dennis C Ko; Jonathan Binkley; Arend Sidow; Matthew P Scott
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2518-25.
2002: Raphaël Rousset; Keith A Wharton; Gregor Zimmermann; Matthew P Scott
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
The Journal of biological chemistry 2002;277(50):49019-26.
2002: Michelle N Arbeitman; Eileen E M Furlong; Farhad Imam; Eric A Johnson; Brian H Null; Bruce S Baker; Mark A Krasnow; Matthew P Scott; Ronald W Davis; Kevin P White
Gene expression during the life cycle of Drosophila melanogaster.
Science (New York, N.Y.) 2002;297(5590):2270-5.
2002: David R P Tree; Joshua M Shulman; Raphaël Rousset; Matthew P Scott; David Gubb; Jeffrey D Axelrod
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.
Cell 2002;109(3):371-81.
2002: Karen S Ho; Matthew P Scott
Sonic hedgehog in the nervous system: functions, modifications and mechanisms.
Current opinion in neurobiology 2002;12(1):57-63.
2001: Joseph B Weiss; Kaye Suyama; H H Lee; Matthew P Scott
Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation.
Cell 2001;107(3):387-98.
2001: Eileen E M Furlong; Erik Andersen; Brian H Null; Kevin P White; Matthew P Scott
Patterns of gene expression during Drosophila mesoderm development.
Science (New York, N.Y.) 2001;293(5535):1629-33.
2001: R B Corcoran; Matthew P Scott
A mouse model for medulloblastoma and basal cell nevus syndrome.
Journal of neuro-oncology 2001;53(3):307-18.
2001: Keith A Wharton; Gregor Zimmermann; Raphaël Rousset; Matthew P Scott
Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling.
Developmental biology 2001;234(1):93-106.
2001: Raphaël Rousset; J A Mack; Keith A Wharton; Jeffrey D Axelrod; Ken M Cadigan; Matthew Fish; Roel Nusse; Matthew P Scott
Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
Genes & development 2001;15(6):658-71.
2001: Dennis C Ko; Michael D Gordon; J Y Jin; Matthew P Scott
Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events.
Molecular biology of the cell 2001;12(3):601-14.
2001: E E Furlong; D Profitt; Matthew P Scott
Automated sorting of live transgenic embryos.
Nature biotechnology 2001;19(2):153-6.
2001: RJ Wechsler-Reya; Matthew P Scott
The developmental biology of brain tumors.
Annual review of neuroscience 2001;24():385-428.
2000: Sophie Chauvet; Samir Merabet; David Bilder; Matthew P Scott; Jacques Pradel; Yacine Graba
Distinct hox protein sequences determine specificity in different tissues.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4064-9.
2000: W Zeng; Keith A Wharton; J A Mack; K Wang; M Gadbaw; K Suyama; P S Klein; Matthew P Scott
naked cuticle encodes an inducible antagonist of Wnt signalling.
Nature 2000;403(6771):789-95.
2000: Matthew P Scott
Development: the natural history of genes.
Cell 2000;100(1):27-40.
1999: Michelle Aszterbaum; J Epstein; Anthony E Oro; V Douglas; P E LeBoit; Matthew P Scott; Ervin H Epstein
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice.
Nature medicine 1999;5(11):1285-91.
1999: Ljiljana Milenkovic; Lisa V Goodrich; Kay Higgins; Matthew P Scott
Mouse patched1 controls body size determination and limb patterning.
Development (Cambridge, England) 1999;126(20):4431-40.
1999: Z Li; Chris A Karlovich; Matthew Fish; Matthew P Scott; Richard Myers
A putative Drosophila homolog of the Huntington's disease gene.
Human molecular genetics 1999;8(9):1807-15.
1999: RV Pearse; Lara S Collier; Matthew P Scott; Clifford J Tabin
Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators.
Developmental biology 1999;212(2):323-36.
1999: Lisa V Goodrich; D Jung; Kay Higgins; Matthew P Scott
Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube.
Developmental biology 1999;211(2):323-34.
1999: RJ Wechsler-Reya; Matthew P Scott
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
Neuron 1999;22(1):103-14.
1998: Lisa V Goodrich; Matthew P Scott
Hedgehog and patched in neural development and disease.
Neuron 1998;21(6):1243-57.
1998: Anthony E Oro; Matthew P Scott
Splitting hairs: dissecting roles of signaling systems in epidermal development.
Cell 1998;95(5):575-8.
1998: Joseph B Weiss; Tonia Von Ohlen; Dervla M Mellerick; Gregory R Dressler; Chris Q Doe; Matthew P Scott
Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity.
Genes & development 1998;12(22):3591-602.
1998: R L Johnson; Matthew P Scott
New players and puzzles in the Hedgehog signaling pathway.
Current opinion in genetics & development 1998;8(4):450-6.
1998: Michelle Aszterbaum; A Rothman; R L Johnson; M Fisher; J Xie; Jeannette Bonifas; Xinjiang Zhang; Matthew P Scott; Ervin H Epstein
Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome.
The Journal of investigative dermatology 1998;110(6):885-8.
1998: David Bilder; Yacine Graba; Matthew P Scott
Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning.
Development (Cambridge, England) 1998;125(9):1781-90.
1997: Lisa V Goodrich; L Milenković; Kay Higgins; Matthew P Scott
Altered neural cell fates and medulloblastoma in mouse patched mutants.
Science (New York, N.Y.) 1997;277(5329):1109-13.
1997: J C Sisson; Karen S Ho; Kaye Suyama; Matthew P Scott
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.
Cell 1997;90(2):235-45.
1997: J Xie; R L Johnson; Xinjiang Zhang; J W Bare; Frederic M Waldman; P H Cogen; A G Menon; Robert S Warren; L C Chen; Matthew P Scott; Ervin H Epstein
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.
Cancer research 1997;57(12):2369-72.
1997: Anthony E Oro; Kay Higgins; Z Hu; Jeannette Bonifas; Ervin H Epstein; Matthew P Scott
Basal cell carcinomas in mice overexpressing sonic hedgehog.
Science (New York, N.Y.) 1997;276(5313):817-21.
1997: Matthew P Scott
Summary: a common language.
Cold Spring Harbor symposia on quantitative biology 1997;62():555-62.
1997: R L Johnson; Matthew P Scott
Control of cell growth and fate by patched genes.
Cold Spring Harbor symposia on quantitative biology 1997;62():205-15.
1996: R L Johnson; A L Rothman; J Xie; Lisa V Goodrich; J W Bare; Jeannette Bonifas; Anthony Quinn; Richard Myers; D R Cox; Ervin H Epstein; Matthew P Scott
Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
Science (New York, N.Y.) 1996;272(5268):1668-71.
1996: Lisa V Goodrich; R L Johnson; Ljiljana Milenkovic; J A McMahon; Matthew P Scott
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Genes & development 1996;10(3):301-12.
1995: R L Johnson; J K Grenier; Matthew P Scott
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets.
Development (Cambridge, England) 1995;121(12):4161-70.
1995: David Bilder; Matthew P Scott
Genomic regions required for morphogenesis of the Drosophila embryonic midgut.
Genetics 1995;141(3):1087-100.
1995: A McCormick; N Coré; Stephen Kerridge; Matthew P Scott
Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene.
Development (Cambridge, England) 1995;121(9):2799-812.
1994: Matthew P Scott
Intimations of a creature.
Cell 1994;79(7):1121-4.
1994: J R Manak; L D Mathies; Matthew P Scott
Regulation of a decapentaplegic midgut enhancer by homeotic proteins.
Development (Cambridge, England) 1994;120(12):3605-19.
1994: L D Mathies; Stephen Kerridge; Matthew P Scott
Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes.
Development (Cambridge, England) 1994;120(10):2799-809.
1994: K Schuske; J E Hooper; Matthew P Scott
patched overexpression causes loss of wingless expression in Drosophila embryos.
Developmental biology 1994;164(1):300-11.
1994: Deborah J Andrew; M A Horner; M G Petitt; Sarah M Smolik; Matthew P Scott
Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes.
The EMBO journal 1994;13(5):1132-44.
1994: J R Manak; Matthew P Scott
A class act: conservation of homeodomain protein functions.
Development (Cambridge, England). Supplement 1994;():61-77.
1993: W Zeng; Deborah J Andrew; L D Mathies; M A Horner; Matthew P Scott
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity.
Development (Cambridge, England) 1993;118(2):339-52.
1993: Matthew P Scott
A rational nomenclature for vertebrate homeobox (HOX) genes.
Nucleic acids research 1993;21(8):1687-8.
1992: Deborah J Andrew; Matthew P Scott
Downstream of the homeotic genes.
The New biologist 1992;4(1):5-15.