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Victoria Scott

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Andrew M Swensen; Timothy A Vortherms; Michael F Jarvis; Lance Lee; Tao Li; Wende Niforatos; Richard J Perner; Michael R Schrimpf; Victoria E Scott; Steve McGaraughty
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.
Xenia Beebe; Janel M Boyce-Rustay; Daria Darczak; Diana L Donnelly-Roberts; Pamela Franklin; Erica Gomez; Rodger F Henry; Richard Janis; Michael F Jarvis; Karen Kage; Kennan Marsh; Ivan Milicic; Marian T Namovic; Wende Niforatos; Gricelda Simler; Andrew O Stewart; Carol S Surowy; Andrew Swensen; Timothy A Vortherms; Jill M Wetter; Chengmin Zhong; Chang Z Zhu; Scott Baker; Victoria E Scott
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.
George A Doherty; Michael F Jarvis; Helmut Mack; Kennan Marsh; Victoria E Scott; Timothy A Vortherms; Jill M Wetter; Pramila Bhatia; Andrew O Stewart
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.

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2012: Andrew M Swensen; Timothy A Vortherms; Michael F Jarvis; Lance Lee; Tao Li; Wende Niforatos; Richard J Perner; Michael R Schrimpf; Victoria E Scott; Steve McGaraughty
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.
Assay and drug development technologies 2012;10(6):542-50.
2012: Xenia Beebe; Janel M Boyce-Rustay; Daria Darczak; Diana L Donnelly-Roberts; Pamela Franklin; Erica Gomez; Rodger F Henry; Richard Janis; Michael F Jarvis; Karen Kage; Kennan Marsh; Ivan Milicic; Marian T Namovic; Wende Niforatos; Gricelda Simler; Andrew O Stewart; Carol S Surowy; Andrew Swensen; Timothy A Vortherms; Jill M Wetter; Chengmin Zhong; Chang Z Zhu; Scott Baker; Victoria E Scott
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.
Bioorganic & medicinal chemistry 2012;20(13):4128-39.
2012: George A Doherty; Michael F Jarvis; Helmut Mack; Kennan Marsh; Victoria E Scott; Timothy A Vortherms; Jill M Wetter; Pramila Bhatia; Andrew O Stewart
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.
Bioorganic & medicinal chemistry letters 2012;22(4):1716-8.
2011: Timothy A Vortherms; Di Zhang; Carol S Surowy; Andrew M Swensen; Rama Thimmapaya; C Brent Putman; Diana L Donnelly-Roberts; Richard S Janis; Michael F Jarvis; James T Limberis; Ruth L Martin; Marian T Namovic; Torben R Neelands; Wende Niforatos; Victoria E Scott
Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011;60(7):683-93.
2008: Jun Chen; Xu-Feng Zhang; Michael E Kort; Jeffrey R Huth; Chaohong Sun; Laura J Miesbauer; Steven C Cassar; Torben R Neelands; Victoria E Scott; Robert B Moreland; Regina M Reilly; Philip J Hajduk; Philip R Kym; Charles W Hutchins; Connie R Faltynek
Molecular determinants of species-specific activation or blockade of TRPA1 channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(19):5063-71.
2008: Rachel Davis-Taber; Scott Baker; Sonya G Lehto; Chengmin Zhong; Carol S Surowy; Connie R Faltynek; Victoria E Scott; Prisca Honore
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.
The journal of pain : official journal of the American Pain Society 2008;9(5):449-56.
2008: Xenia Beebe; Daria Darczak; Rachel Davis-Taber; Marie E Uchic; Victoria E Scott; Michael F Jarvis; Andrew O Stewart
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).
Bioorganic & medicinal chemistry letters 2008;18(6):2162-6.
2008: John Malysz; Victoria E Scott; Connie R Faltynek; Murali Gopalakrishnan
Characterization of human ASIC2a homomeric channels stably expressed in murine Ltk- cells.
Life sciences 2008;82(1-2):30-40.
2007: Arturo Perez-Medrano; Michael E Brune; Steven A Buckner; Michael J Coghlan; Thomas A Fey; Murali Gopalakrishnan; Robert J Gregg; Michael E Kort; Victoria E Scott; James P Sullivan; Kristi Whiteaker; William A Carroll
Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
Journal of medicinal chemistry 2007;50(24):6265-73.
2007: Chaohong Sun; Danying Song; Rachel Davis-Taber; Leo W Barrett; Victoria E Scott; Paul L Richardson; Ana Pereda-Lopez; Marie E Uchic; Larry R Solomon; Marc R Lake; Karl A Walter; Philip J Hajduk; Edward T Olejniczak
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7875-80.
2007: Wende Niforatos; Xu-Feng Zhang; Marc R Lake; Karl A Walter; Torben R Neelands; Thomas F Holzman; Victoria E Scott; Connie R Faltynek; Robert B Moreland; Jun Chen
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
Molecular pharmacology 2007;71(5):1209-16.
2007: Karen Kage; Paul L Richardson; Linda M Traphagen; Jean M Severin; Ana Pereda-Lopez; Thomas Lubben; Rachel Davis-Taber; Melissa H Vos; Diane M Bartley; Karl Walter; John Harlan; Larry Solomon; Usha Warrior; Thomas F Holzman; Connie R Faltynek; Carol S Surowy; Victoria E Scott
A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase.
Journal of neuroscience methods 2007;161(1):47-54.
2007: Jun Chen; Marc R Lake; Reza S Sabet; Wende Niforatos; Steve D Pratt; Steven C Cassar; Jing Xu; Sujatha M Gopalakrishnan; Ana Pereda-Lopez; Murali Gopalakrishnan; Thomas F Holzman; Robert B Moreland; Karl A Walter; Connie R Faltynek; Usha Warrior; Victoria E Scott
Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists.
Journal of biomolecular screening 2007;12(1):61-9.
2006: Robert J Altenbach; Michael E Brune; Steven A Buckner; Michael J Coghlan; Anthony V Daza; Adebola Fabiyi; Murali Gopalakrishnan; Rodger F Henry; Albert Khilevich; Michael E Kort; Ivan Milicic; Victoria E Scott; Jamie C Smith; Kristi Whiteaker; William A Carroll
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
Journal of medicinal chemistry 2006;49(23):6869-87.
2005: Rama Thimmapaya; Torben R Neelands; Wende Niforatos; Rachel Davis-Taber; Won Choi; C Brent Putman; Paul Kroeger; jeremy packer; Murali Gopalakrishnan; Connie R Faltynek; Carol S Surowy; Victoria E Scott
Distribution and functional characterization of human Nav1.3 splice variants.
The European journal of neuroscience 2005;22(1):1-9.
2004: Murali Gopalakrishnan; Steven A Buckner; Char-Chang Shieh; Thomas A Fey; Adebola Fabiyi; Kristi Whiteaker; Rachel Davis-Taber; Ivan Milicic; Anthony V Daza; Victoria E Scott; Neil A Castle; David Printzenhoff; Brecht London; Sean C Turner; William A Carroll; James P Sullivan; Michael J Coghlan; Michael E Brune
In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
British journal of pharmacology 2004;143(1):81-90.
2004: Xu-Feng Zhang; Chang Z Zhu; Rama Thimmapaya; Won S Choi; Prisca Honore; Victoria E Scott; Paul Kroeger; James P Sullivan; Connie R Faltynek; Murali Gopalakrishnan; Char-Chang Shieh
Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury.
Brain research 2004;1009(1-2):147-58.
2004: Irene Drizin; Robert J Altenbach; Steven A Buckner; Kristi Whiteaker; Victoria E Scott; John F Darbyshire; Venkata K Jayanti; Rodger F Henry; Michael J Coghlan; Murali Gopalakrishnan; William A Carroll
Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers.
Bioorganic & medicinal chemistry 2004;12(8):1895-904.
2004: Arturo Perez-Medrano; Steven A Buckner; Michael J Coghlan; Robert J Gregg; Murali Gopalakrishnan; Michael E Kort; John K Lynch; Victoria E Scott; James P Sullivan; Kristi Whiteaker; William A Carroll
Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
Bioorganic & medicinal chemistry letters 2004;14(2):397-400.
2004: Victoria E Scott; Rachel Davis-Taber; Christopher Silvia; Lisa Hoogenboom; Won Choi; Paul Kroeger; Kristi Whiteaker; Murali Gopalakrishnan
Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells.
European journal of pharmacology 2004;483(2-3):195-205.
2003: Ashutosh S Parihar; Duncan R Groebe; Victoria E Scott; Jianlin Feng; Xu-Feng Zhang; Usha Warrior; Murali Gopalakrishnan; Char-Chang Shieh
Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry.
Assay and drug development technologies 2003;1(5):647-54.
2003: Rachel Davis-Taber; Eduardo J Molinari; Robert J Altenbach; Kristi Whiteaker; Char-Chang Shieh; Gary Rotert; Steven A Buckner; John Malysz; Ivan Milicic; Jeffrey S McDermott; Gary Gintant; Michael J Coghlan; William A Carroll; Victoria E Scott; Murali Gopalakrishnan
[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.
Molecular pharmacology 2003;64(1):143-53.
2003: Sean C Turner; William A Carroll; Tammie K White; Michael E Brune; Steven A Buckner; Murali Gopalakrishnan; Adebola Fabiyi; Michael J Coghlan; Victoria E Scott; Neil A Castle; Anthony V Daza; Ivan Milicic; James P Sullivan
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Bioorganic & medicinal chemistry letters 2003;13(10):1741-4.
2003: Murali Gopalakrishnan; Thomas R Miller; Steven A Buckner; Ivan Milicic; Eduardo J Molinari; Kristi Whiteaker; Rachel Davis-Taber; Victoria E Scott; Christopher Cassidy; James P Sullivan; William A Carroll
Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.
British journal of pharmacology 2003;138(2):393-9.
2002: Murali Gopalakrishnan; Steven A Buckner; Kristi Whiteaker; Char-Chang Shieh; Eduardo J Molinari; Ivan Milicic; Anthony V Daza; Rachel Davis-Taber; Victoria E Scott; Donna J Sellers; Russell Chess-Williams; Christopher Chapple; Yi Liu; Dong Liu; Jorge D Brioni; James P Sullivan; Michael Williams; William A Carroll; Michael J Coghlan
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization.
The Journal of pharmacology and experimental therapeutics 2002;303(1):379-86.
2001: Kristi Whiteaker; Sujatha M Gopalakrishnan; Duncan R Groebe; Char-Chang Shieh; Usha Warrior; David J Burns; Michael J Coghlan; Victoria E Scott; Murali Gopalakrishnan
Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators.
Journal of biomolecular screening 2001;6(5):305-12.
2001: Kristi Whiteaker; Rachel Davis-Taber; Victoria E Scott; Murali Gopalakrishnan
Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes.
Journal of pharmacological and toxicological methods 2001;46(1):45-50.
2000: Rachel Davis-Taber; Won Choi; J Feng; L Hoogenboom; Teresa McNally; Paul Kroeger; Char-Chang Shieh; Robert L Simmer; Jorge D Brioni; James P Sullivan; Murali Gopalakrishnan; Victoria E Scott
Molecular characterization of human SUR2-containing K(ATP) channels.
Gene 2000;256(1-2):261-70.
2000: Steven A Buckner; Ivan Milicic; Anthony V Daza; Rachel Davis-Taber; Victoria E Scott; James P Sullivan; Jorge D Brioni
Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor.
European journal of pharmacology 2000;400(2-3):287-95.
2000: Murali Gopalakrishnan; Eduardo J Molinari; Char-Chang Shieh; LM Monteggia; Jean M Roch; Kristi Whiteaker; Victoria E Scott; James P Sullivan; Jorge D Brioni
Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells.
British journal of pharmacology 2000;129(7):1323-32.
1999: Thomas R Miller; R D Taber; Eduardo J Molinari; Kristi Whiteaker; LM Monteggia; Victoria E Scott; Jorge D Brioni; James P Sullivan; Murali Gopalakrishnan
Pharmacological and molecular characterization of ATP-sensitive K+ channels in the TE671 human medulloblastoma cell line.
European journal of pharmacology 1999;370(2):179-85.
1999: Murali Gopalakrishnan; Kristi Whiteaker; Eduardo J Molinari; Rachel Davis-Taber; Victoria E Scott; Char-Chang Shieh; Steven A Buckner; Ivan Milicic; John C Cain; Steve P Postl; James P Sullivan; Jorge D Brioni
Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells.
The Journal of pharmacology and experimental therapeutics 1999;289(1):551-8.