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Andrea Scozzafava

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Francesca Bellissima; Piero Baglioni; Fabrizio Carta; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran; Debora Berti
Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor.
Shyamasri Biswas; Fabrizio Carta; Robert McKenna; Andrea Scozzafava; Claudiu T Supuran
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.
Marta Ferraroni; Irene Matera; Sabrina Reichert; Andrea Scozzafava; Lenz Steimer; Andreas Stolz; Sibylle Bürger; Fabrizio Briganti
The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate.

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All Publications

2013: Francesca Bellissima; Piero Baglioni; Fabrizio Carta; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran; Debora Berti
Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor.
The European physical journal. E, Soft matter 2013;36(5):9862.
2013: Shyamasri Biswas; Fabrizio Carta; Robert McKenna; Andrea Scozzafava; Claudiu T Supuran
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.
Bioorganic & medicinal chemistry 2013;21(8):2314-8.
2013: Marta Ferraroni; Irene Matera; Sabrina Reichert; Andrea Scozzafava; Lenz Steimer; Andreas Stolz; Sibylle Bürger; Fabrizio Briganti
The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate.
The FEBS journal 2013;280(7):1643-52.
2013: Marta Ferraroni; Ludmila A Golovleva; Marina P Kolomytseva; Andrea Scozzafava
X-ray crystallographic and molecular docking studies on a unique chloromuconolactone dehalogenase from Rhodococcus opacus 1CP.
Journal of structural biology 2013;182(1):44-50.
2013: Cemalettin Alp; Nurdan Alcan Alp; Deniz Ekinci; Mehmet Serdar Gültekin; Alfonso Maresca; Andrea Scozzafava; Claudiu T Supuran
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.
Journal of enzyme inhibition and medicinal chemistry 2013;28(2):294-8.
2013: Alfonso Maresca; Andrea Scozzafava; Gheorghe Manole; Daniela Vullo; Claudiu T Supuran
Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids.
Journal of enzyme inhibition and medicinal chemistry 2013;28(2):392-6.
2013: Alfonso Maresca; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions.
Journal of enzyme inhibition and medicinal chemistry 2013;28(2):388-91.
2013: Alfonso Maresca; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases from Mycobacterium tuberculosis.
Journal of enzyme inhibition and medicinal chemistry 2013;28(2):384-7.
2013: Daniela Vullo; Vincenzo Carginale; Viviana De Luca; Sonia Del Prete; Semra Isik; Andrea Scozzafava; Claudiu T Supuran; Clemente Capasso
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Bioorganic & medicinal chemistry letters 2013;23(6):1636-8.
2013: Simona Maria Monti; Andrea Scozzafava; Daniela Vullo; Clemente Capasso; Nina Dathan; Giuseppina De simone; Martha Ludwig; Claudiu T Supuran
Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.
Bioorganic & medicinal chemistry letters 2013;23(6):1626-30.
2013: Tiphaine Rogez-Florent; Andrea Scozzafava; Perrine Six; Claudiu T Supuran; Christine Bal-Mahieu; Patrick Depreux; Catherine Foulon; Raphaël Frédérick; Sébastien Gluszok; Jean-François Goossens; Abigaëlle Gros; Amélie Lansiaux; Bernard Masereel; Samuel Meignan; Laurence Goossens
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.
Bioorganic & medicinal chemistry 2013;21(6):1451-64.
2013: Viviana De Luca; Mosè Rossi; Andrea Scozzafava; Claudiu T Supuran; Daniela Vullo; Vincenzo Carginale; Clemente Capasso
An α-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction.
Bioorganic & medicinal chemistry 2013;21(6):1465-9.
2013: Daniela Vullo; Vincenzo Carginale; Viviana De Luca; Mosè Rossi; Andrea Scozzafava; Claudiu T Supuran; Clemente Capasso
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
Bioorganic & medicinal chemistry 2013;21(6):1534-8.
2013: Fabrizio Carta; Alfonso Maresca; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.
Bioorganic & medicinal chemistry 2013;21(6):1564-9.
2013: Marta Ferraroni; Ludmila A Golovleva; Marina P Kolomytseva; Andrea Scozzafava; Fabrizio Briganti
X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.
Journal of structural biology 2013;181(3):274-82.
2013: Atilla Akdemir; Vincenzo Carginale; Mosè Rossi; Andrea Scozzafava; Claudiu T Supuran; Daniela Vullo; Viviana De Luca; Clemente Capasso
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
Bioorganic & medicinal chemistry letters 2013;23(4):1087-90.
2013: Murat Bozdag; Fabrizio Carta; Tobias Dreker; Roberta Fruttero; Christophe Henry; Andrea Scozzafava; Paolo Tosco; Maura Vallaro; Claudiu T Supuran
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(3):715-9.
2013: Andrea Scozzafava; Fabrizio Carta; Claudiu T Supuran
Secondary and tertiary sulfonamides: a patent review (2008 - 2012).
Expert opinion on therapeutic patents 2013;23(2):203-13.
2013: Kaspars Tars; Daniela Vullo; Raivis Zalubovskis; Aiga Grandane; Andris Kazaks; Janis Leitans; Alons Lends; Andrea Scozzafava; Claudiu T Supuran
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.
Journal of medicinal chemistry 2013;56(1):293-300.
2013: Emanuela Masini; Andrea Scozzafava; Fabrizio Carta; Claudiu T Supuran
Antiglaucoma carbonic anhydrase inhibitors: a patent review.
Expert opinion on therapeutic patents 2013;23(6):705-16.
2013: Andrea Scozzafava; Claudiu T Supuran; Fabrizio Carta
Antiobesity carbonic anhydrase inhibitors: a literature and patent review.
Expert opinion on therapeutic patents 2013;23(6):725-35.
2013: Isao Nishimori; Andrea Scozzafava; Clemente Capasso; Tomoko Minakuchi; Daniela Vullo; Claudiu T Supuran
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
Bioorganic & medicinal chemistry letters 2013;23(1):256-60.
2012: Sonia Del Prete; Semra Isik; Andrea Scozzafava; Claudiu T Supuran; Daniela Vullo; Vincenzo Carginale; Viviana De Luca; Clemente Capasso
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Journal of medicinal chemistry 2012;55(23):10742-8.
2012: Daniela Vullo; Vincenzo Carginale; Viviana De Luca; Mosè Rossi; Andrea Scozzafava; Claudiu T Supuran; Clemente Capasso
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.
Bioorganic & medicinal chemistry letters 2012;22(23):7142-5.
2012: Marta Ferraroni; Irene Matera; Andrea Scozzafava; Lenz Steimer; Andreas Stolz; Sibylle Bürger; Fabrizio Briganti
The generation of a 1-hydroxy-2-naphthoate 1,2-dioxygenase by single point mutations of salicylate 1,2-dioxygenase--rational design of mutants and the crystal structures of the A85H and W104Y variants.
Journal of structural biology 2012;180(3):563-71.
2012: Anna M Marini; Robert McKenna; Susanna Nencetti; Elisa Nuti; Elisabetta Orlandini; Armando Rossello; Silvia Salerno; Andrea Scozzafava; Francesca Simorini; Mayank Aggarwal; Federico Da Settimo; Concettina La Motta; Alfonso Maresca; Sabrina Taliani; Claudiu T Supuran
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.
Journal of medicinal chemistry 2012;55(22):9619-29.
2012: Daniela Vullo; Vincenzo Carginale; Viviana De Luca; Mosè Rossi; Andrea Scozzafava; Claudiu T Supuran; Clemente Capasso
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
Bioorganic & medicinal chemistry letters 2012;22(20):6324-7.
2012: Ilaria Ciullini; Antonella Gullotto; Giovanni Sannia; Andrea Scozzafava; Silvia Tilli; Riccardo Basosi; Fabrizio Briganti
Enzymatic decolorization of spent textile dyeing baths composed by mixtures of synthetic dyes and additives.
Applied microbiology and biotechnology 2012;96(2):395-405.
2012: Mario Sechi; Mauro Carcelli; Alessio Innocenti; Nicolino Pala; Dominga Rogolino; Andrea Scozzafava; Claudiu T Supuran
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(18):5801-6.
2012: Viviana De Luca; Mosè Rossi; Andrea Scozzafava; Claudiu T Supuran; Daniela Vullo; Vincenzo Carginale; Clemente Capasso
Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.
Bioorganic & medicinal chemistry letters 2012;22(17):5630-4.
2012: Jean-Yves Winum; Fabrizio Carta; Alfonso Maresca; Andrea Scozzafava; Claudiu T Supuran
Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.
Chemical communications (Cambridge, England) 2012;48(66):8177-9.
2012: Jean-Yves Winum; Carol Ward; Fabrizio Carta; Alessandro Cecchi; David Harrison; Ian Kunkler; Simon P Langdon; Peter Mullen; Andrea Scozzafava; Claudiu T Supuran
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.
Bioorganic & medicinal chemistry letters 2012;22(14):4681-5.
2012: Fabrizio Carta; Andrea Scozzafava; Claudiu T Supuran
Sulfonamides: a patent review (2008 - 2012).
Expert opinion on therapeutic patents 2012;22(7):747-58.
2012: Roben G Gieling; Lupti Mamnani; Andrea Scozzafava; Claudiu T Supuran; Brian A Telfer; Muhammad Babur; Natalie Burrows; Fabrizio Carta; Jean-Yves Winum; Kaye J Williams
Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.
Journal of medicinal chemistry 2012;55(11):5591-600.
2012: Serdar Durdagi; Vesa P Hytönen; Niklas Kähkönen; Juha A Määttä; Peiwen Pan; Seppo Parkkila; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Protein-protein interactions: inhibition of mammalian carbonic anhydrases I-XV by the murine inhibitor of carbonic anhydrase and other members of the transferrin family.
Journal of medicinal chemistry 2012;55(11):5529-35.
2012: Marta Ferraroni; Ludmila A Golovleva; Marina P Kolomytseva; Irene Matera; Andrea Scozzafava; Alexey Chernykh; Fabrizio Briganti
Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.
Journal of inorganic biochemistry 2012;111():203-9.
2012: Stefano Da Vela; Marta Ferraroni; Eva Keller; Boris A Kolvenbach; Andrea Scozzafava; P F X Corvini; Fabrizio Briganti
Crystallization and preliminary X-ray crystallographic analysis of hydroquinone dioxygenase from Sphingomonas sp. TTNP3.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 5):588-90.
2012: Gianfranco Balboni; Cenzo Congiu; Annalisa Maietti; Alfonso Maresca; Valentina Onnis; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Bioorganic & medicinal chemistry letters 2012;22(9):3063-6.
2012: Alfonso Maresca; Andrea Scozzafava; Stephan Köhler; Jean-Yves Winum; Claudiu T Supuran
Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions.
Journal of inorganic biochemistry 2012;110():36-9.
2012: Kirsty S Hewitson; Antonio Mastrolorenzo; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
Journal of medicinal chemistry 2012;55(7):3513-20.
2012: Seppo Parkkila; Andrea Scozzafava; Fabrizio Carta; Alfonso Maresca; Daniela Vullo; Claudiu T Supuran
Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.
Chemical communications (Cambridge, England) 2012;48(29):3551-3.
2012: Fabrizio Carta; Alfonso Maresca; Andrea Scozzafava; Claudiu T Supuran
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.
Bioorganic & medicinal chemistry 2012;20(7):2266-73.
2012: Fabrizio Carta; Alfonso Maresca; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.
Bioorganic & medicinal chemistry letters 2012;22(6):2182-5.
2012: Fabrizio Carta; Alfonso Maresca; Emanuela Masini; Robert McKenna; Andrea Scozzafava; Mayank Aggarwal; Claudiu T Supuran
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.
Journal of medicinal chemistry 2012;55(4):1721-30.
2012: Fabrizio Carta; Alfonso Maresca; Robert McKenna; Andrea Scozzafava; Mayank Aggarwal; Claudiu T Supuran
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations.
Chemical communications (Cambridge, England) 2012;48(13):1868-70.
2012: Claudiu T Supuran; Andrea Scozzafava
Heterocyclic urea derivatives and methods of use thereof (WO2010142978).
Expert opinion on therapeutic patents 2012;22(2):193-7.
2012: Marta Ferraroni; Irene Matera; Andrea Scozzafava; Lenz Steimer; Andreas Stolz; Sibylle Bürger; Fabrizio Briganti
Crystal structures of salicylate 1,2-dioxygenase-substrates adducts: A step towards the comprehension of the structural basis for substrate selection in class III ring cleaving dioxygenases.
Journal of structural biology 2012;177(2):431-8.
2012: Mario Perez-Sayans; Andrea Scozzafava; Abel Garcia-Garcia; Claudiu T Supuran
Inhibition of V-ATPase and carbonic anhydrases as interference strategy with tumor acidification processes.
Current pharmaceutical design 2012;18(10):1407-13.
2011: Silvia Tilli; Ilaria Ciullini; Andrea Scozzafava; Fabrizio Briganti
Differential decolorization of textile dyes in mixtures and the joint effect of laccase and cellobiose dehydrogenase activities present in extracellular extracts from Funalia trogii.
Enzyme and microbial technology 2011;49(5):465-71.
2011: Edward E Knaus; Andrea Scozzafava; Alessio Innocenti; Claudiu T Supuran
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.
Bioorganic & medicinal chemistry letters 2011;21(19):5892-6.
2011: Marouan Rami; Andrea Scozzafava; Alessio Innocenti; Jean-Louis Montero; Jean-Yves Winum; Claudiu T Supuran
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.
Bioorganic & medicinal chemistry letters 2011;21(18):5210-3.
2011: Isao Nishimori; Andrea Scozzafava; Tomoko Minakuchi; Daniela Vullo; Claudiu T Supuran
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
Bioorganic & medicinal chemistry 2011;19(16):5023-30.
2011: Mohamed-Chiheb Saada; Andrea Scozzafava; Daniela Vullo; Jean-Yves Winum; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.
Bioorganic & medicinal chemistry letters 2011;21(16):4884-7.
2011: Shyamasri Biswas; Robert McKenna; Andrea Scozzafava; Mayank Aggarwal; Özlen Güzel; Claudiu T Supuran
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry 2011;19(12):3732-8.
2011: Daniela Vullo; Isao Nishimori; Tomoko Minakuchi; Andrea Scozzafava; Claudiu T Supuran
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.
Bioorganic & medicinal chemistry letters 2011;21(12):3591-5.
2011: Naama Hen; Meir Bialer; Boris Yagen; Alfonso Maresca; Mayank Aggarwal; Arthur H Robbins; Robert McKenna; Andrea Scozzafava; Claudiu T Supuran
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
Journal of medicinal chemistry 2011;54(11):3977-81.
2011: Ludwig Dubois; Nele Geusens; Adrian L Harris; Fabrizio Carta; Jean-Michel Dogné; Natasja Lieuwes; Bernard Masereel; Alan McIntyre; Sarah Peeters; Andrea Scozzafava; Claudiu T Supuran; Anne Thiry; Simon Wigfield; Philippe Lambin
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011;99(3):424-31.
2011: Francesco Mincione; Francesca Benedini; Stefano Biondi; Alessandro Cecchi; Claudia Temperini; Giuseppe Formicola; Ilaria Pacileo; Andrea Scozzafava; Emanuela Masini; Claudiu T Supuran
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.
Bioorganic & medicinal chemistry letters 2011;21(11):3216-21.
2011: Fabrizio Carta; Vladimir Garaj; Alfonso Maresca; Jason Wagner; Balendu Sankara Avvaru; Arthur H Robbins; Andrea Scozzafava; Robert McKenna; Claudiu T Supuran
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Bioorganic & medicinal chemistry 2011;19(10):3105-19.
2011: Marouan Rami; Alfonso Maresca; Fatma-Zhora Smaine; Jean-Louis Montero; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.
Bioorganic & medicinal chemistry letters 2011;21(10):2975-9.
2011: Andrea Scozzafava; Claudiu T Supuran
Heterocyclic compounds and their uses: a patent evaluation of WO2010151735A2.
Expert opinion on therapeutic patents 2011;21(5):803-6.
2011: Yuanmei Lou; Paul C McDonald; Andrew Minchinton; Arusha Oloumi; Christina Ostlund; Christopher M Overall; Fabio Pacchiano; Calvin Roskelley; Andrea Scozzafava; Claudiu T Supuran; Brent W Sutherland; Nadia Touisni; Dawn Waterhouse; Jean-Yves Winum; Ardalan Ahmadi; Ulrich auf dem Keller; Marcel Bally; Fabrizio Carta; Stephen Chia; Blaise Clarke; David Huntsman; Alastair Kyle; Samuel Leung; Shoukat Dedhar
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
Cancer research 2011;71(9):3364-76.
2011: Khyati Dave; Marc A Ilies; Andrea Scozzafava; Claudia Temperini; Daniela Vullo; Claudiu T Supuran
An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.
Bioorganic & medicinal chemistry letters 2011;21(9):2764-8.
2011: Khyati Dave; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran; Marc A Ilies
Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII.
Organic & biomolecular chemistry 2011;9(8):2790-800.
2011: Fabrizio Carta; Alessio Innocenti; Rebecca A Hall; Fritz A Mühlschlegel; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives.
Bioorganic & medicinal chemistry letters 2011;21(8):2521-6.
2011: Fabio Pacchiano; Fabrizio Carta; Paul C McDonald; Yuanmei Lou; Daniela Vullo; Andrea Scozzafava; Shoukat Dedhar; Claudiu T Supuran
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.
Journal of medicinal chemistry 2011;54(6):1896-902.
2011: Alessandra Cincinelli; Tania Martellini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.
Bioorganic & medicinal chemistry 2011;19(6):1847-51.
2011: Mohamed-Chiheb Saada; Jean-Louis Montero; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms.
Journal of medicinal chemistry 2011;54(5):1170-7.
2011: Serdar Durdagi; Murat Şentürk; Deniz Ekinci; Halis Türker Balaydın; Süleyman Göksu; Ö İrfan Küfrevioğlu; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.
Bioorganic & medicinal chemistry 2011;19(4):1381-9.
2011: Pascale Joseph; Safia Ouahrani-Bettache; Jean-Louis Montero; Isao Nishimori; Tomoko Minakuchi; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Stephan Köhler; Claudiu T Supuran
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
Bioorganic & medicinal chemistry 2011;19(3):1172-8.
2011: Anthony Bertucci; Alessio Innocenti; Andrea Scozzafava; Sylvie Tambutté; Didier Zoccola; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
Bioorganic & medicinal chemistry letters 2011;21(2):710-4.
2011: Peter Burghout; Daniela Vullo; Andrea Scozzafava; Peter W M Hermans; Claudiu T Supuran
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?
Bioorganic & medicinal chemistry 2011;19(1):243-8.
2011: Fabio Pacchiano; Fabrizio Carta; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides.
Bioorganic & medicinal chemistry letters 2011;21(1):102-5.
2010: Alfonso Maresca; Andrea Scozzafava; Claudiu T Supuran
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
Bioorganic & medicinal chemistry letters 2010;20(24):7255-8.
2010: Fabio Pacchiano; Mayank Aggarwal; Balendu Sankara Avvaru; Arthur H Robbins; Andrea Scozzafava; Robert McKenna; Claudiu T Supuran
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chemical communications (Cambridge, England) 2010;46(44):8371-3.
2010: Sébastien Gluszok; Raphaël Frédérick; Catherine Foulon; Frédérique Klupsch; Claudiu T Supuran; Daniela Vullo; Andrea Scozzafava; Jean-François Goossens; Bernard Masereel; Patrick Depreux; Laurence Goossens
Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.
Bioorganic & medicinal chemistry 2010;18(21):7392-401.
2010: Alessio Innocenti; Ilhami Gülçin; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.
Bioorganic & medicinal chemistry letters 2010;20(17):5050-3.
2010: Francesca Viparelli; Simona Maria Monti; Giuseppina De simone; Alessio Innocenti; Andrea Scozzafava; Yan Xu; François M M Morel; Claudiu T Supuran
Inhibition of the R1 fragment of the cadmium-containing zeta-class carbonic anhydrase from the diatom Thalassiosira weissflogii with anions.
Bioorganic & medicinal chemistry letters 2010;20(16):4745-8.
2010: Fabrizio Carta; Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Kai Kaila; Claudiu T Supuran
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Journal of medicinal chemistry 2010;53(15):5511-22.
2010: Balendu Sankara Avvaru; Jason M Wagner; Alfonso Maresca; Andrea Scozzafava; Arthur H Robbins; Claudiu T Supuran; Robert McKenna
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(15):4376-81.
2010: Jason Wagner; Balendu Sankara Avvaru; Arthur H Robbins; Andrea Scozzafava; Claudiu T Supuran; Robert McKenna
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.
Bioorganic & medicinal chemistry 2010;18(14):4873-8.
2010: Irene Matera; Marta Ferraroni; Marina P Kolomytseva; Ludmila A Golovleva; Andrea Scozzafava; Fabrizio Briganti
Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts.
Journal of structural biology 2010;170(3):548-64.
2010: Ozlen Güzel; Alfonso Maresca; Rebecca A Hall; Andrea Scozzafava; Antonio Mastrolorenzo; Fritz A Mühlschlegel; Claudiu T Supuran
Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry letters 2010;20(8):2508-11.
2010: Daniela Vullo; Isao Nishimori; Andrea Scozzafava; Stephan Köhler; Jean-Yves Winum; Claudiu T Supuran
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.
Bioorganic & medicinal chemistry letters 2010;20(7):2178-82.
2010: Pascale Joseph; François Turtaut; Safia Ouahrani-Bettache; Jean-Louis Montero; Isao Nishimori; Tomoko Minakuchi; Daniela Vullo; Andrea Scozzafava; Stephan Köhler; Jean-Yves Winum; Claudiu T Supuran
Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.
Journal of medicinal chemistry 2010;53(5):2277-85.
2010: Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamate.
Bioorganic & medicinal chemistry letters 2010;20(5):1548-50.
2010: Alessio Innocenti; Worraanong Leewattanapasuk; Gheorghe Manole; Andrea Scozzafava; Fritz A Mühlschlegel; Claudiu T Supuran
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
Bioorganic & medicinal chemistry letters 2010;20(5):1701-4.
2010: Alessio Innocenti; Rebecca A Hall; Andrea Scozzafava; Fritz A Mühlschlegel; Claudiu T Supuran
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
Bioorganic & medicinal chemistry 2010;18(3):1034-7.
2010: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Seppo Parkkila; Claudiu T Supuran
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.
Journal of medicinal chemistry 2010;53(2):850-4.
2010: Claudia Temperini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme.
Bioorganic & medicinal chemistry letters 2010;20(2):474-8.
2010: Alfonso Maresca; Claudia Temperini; Lionel Pochet; Bernard Masereel; Andrea Scozzafava; Claudiu T Supuran
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Journal of medicinal chemistry 2010;53(1):335-44.
2010: Harun M Said; Claudiu T Supuran; Carsten Hageman; Adrian Staab; Buelent Polat; Astrid Katzer; Andrea Scozzafava; Jelena Anacker; Michael Flentje; Dirk Vordermark
Modulation of carbonic anhydrase 9 (CA9) in human brain cancer.
Current pharmaceutical design 2010;16(29):3288-99.
2010: Isao Nishimori; Tomoko Minakuchi; Alfonso Maresca; Fabrizio Carta; Andrea Scozzafava; Claudiu T Supuran
The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets.
Current pharmaceutical design 2010;16(29):3300-9.
2010: Ozlen Güzel; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors.
Current pharmaceutical design 2010;16(29):3317-26.
2010: Leo Syrjänen; Martti Tolvanen; Mika Hilvo; Ayodeji Olatubosun; Alessio Innocenti; Andrea Scozzafava; Jenni Leppiniemi; Barbara Niederhauser; Vesa P Hytönen; Thomas A Gorr; Seppo Parkkila; Claudiu T Supuran
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates.
BMC biochemistry 2010;11():28.
2009: Fabrizio Carta; Alfonso Maresca; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.
Bioorganic & medicinal chemistry 2009;17(20):7093-9.
2009: Alessio Innocenti; Silvia Pastorekova; Jaromir Pastorek; Andrea Scozzafava; Giuseppina De Simone; Claudiu T Supuran
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Bioorganic & medicinal chemistry letters 2009;19(20):5825-8.
2009: vincenzo alterio; Mika Hilvo; Anna Di Fiore; Claudiu T Supuran; Peiwen Pan; Seppo Parkkila; Andrea Scaloni; Jaromir Pastorek; Silvia Pastorekova; Carlo Pedone; Andrea Scozzafava; Simona Maria Monti; Giuseppina De simone
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16233-8.
2009: Giuseppina De Simone; Andrea Scozzafava; Claudiu T Supuran
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?
Chemical biology & drug design 2009;74(3):317-21.
2009: Alfonso Maresca; Fabrizio Carta; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.
Bioorganic & medicinal chemistry letters 2009;19(17):4929-32.
2009: Ludwig Dubois; Natasja Lieuwes; Alfonso Maresca; Anne Thiry; Claudiu T Supuran; Andrea Scozzafava; Bradly G Wouters; Philippe Lambin
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2009;92(3):423-8.
2009: Seppo Parkkila; Alessio Innocenti; Heini Kallio; Mika Hilvo; Andrea Scozzafava; Claudiu T Supuran
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry letters 2009;19(15):4102-6.
2009: Ozlen Güzel; Alessio Innocenti; Andrea Scozzafava; Aydin Salman; Claudiu T Supuran
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Bioorganic & medicinal chemistry 2009;17(14):4894-9.
2009: Anthony Bertucci; Alessio Innocenti; Didier Zoccola; Andrea Scozzafava; Sylvie Tambutté; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
Bioorganic & medicinal chemistry 2009;17(14):5054-8.
2009: Ozlen Güzel; Alfonso Maresca; Andrea Scozzafava; Aydin Salman; Alexandru T Balaban; Claudiu T Supuran
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Journal of medicinal chemistry 2009;52(13):4063-7.
2009: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Inhibition of carbonic anhydrase IX: a new strategy against cancer.
Anti-cancer agents in medicinal chemistry 2009;9(6):693-702.
2009: Alessio Innocenti; Mika Hilvo; Seppo Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2009;19(13):3430-3.
2009: Alessio Innocenti; Rebecca A Hall; Christine Schlicker; Andrea Scozzafava; Clemens Steegborn; Fritz A Mühlschlegel; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
Bioorganic & medicinal chemistry 2009;17(13):4503-9.
2009: Ozlen Güzel; Alessio Innocenti; Andrea Scozzafava; Aydin Salman; Claudiu T Supuran
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(12):3170-3.
2009: Ozlen Güzel; Alfonso Maresca; Andrea Scozzafava; Aydin Salman; Alexandru T Balaban; Claudiu T Supuran
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.
Bioorganic & medicinal chemistry letters 2009;19(11):2931-4.
2009: Jean-Yves Winum; Alessio Innocenti; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.
Bioorganic & medicinal chemistry 2009;17(10):3649-52.
2009: Alessio Innocenti; Jean-Yves Winum; Rebecca A Hall; Fritz A Mühlschlegel; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Bioorganic & medicinal chemistry letters 2009;19(10):2642-5.
2009: Isao Nishimori; Tomoko Minakuchi; Daniela Vullo; Andrea Scozzafava; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
Journal of medicinal chemistry 2009;52(9):3116-20.
2009: Marie-Rose Abdo; Daniela Vullo; Mohamed-Chiheb Saada; Jean-Louis Montero; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.
Bioorganic & medicinal chemistry letters 2009;19(9):2440-3.
2009: Tomoko Minakuchi; Isao Nishimori; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
Journal of medicinal chemistry 2009;52(8):2226-32.
2009: Ozlen Güzel; Alessio Innocenti; Rebecca A Hall; Andrea Scozzafava; Fritz A Mühlschlegel; Claudiu T Supuran
Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2009;17(8):3212-5.
2009: Peter Ebbesen; Erik O Pettersen; Thomas A Gorr; Gerhard Jobst; Kaye Williams; Jochen Kieninger; Roland H Wenger; Silvia Pastorekova; Ludwig Dubois; Philippe Lambin; Brad G Wouters; Twan van den Beucken; Claudiu T Supuran; Lorenz Poellinger; Peter Ratcliffe; Arvydas Kanopka; Agnes Görlach; Max Gasmann; Adrian L Harris; Patrick Maxwell; Andrea Scozzafava
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.
Journal of enzyme inhibition and medicinal chemistry 2009;24 Suppl 1():1-39.
2009: Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(7):1855-7.
2009: Shalini Singh; Padmakar V Khadikar; Andrea Scozzafava; Claudiu T Supuran
QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):337-49.
2009: Salwa M I Morsy; Abdelfattah M Badawi; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):499-505.
2009: Semra Isik; Feray Kockar; Meltem Aydin; Oktay Arslan; Ozen Ozensoy Guler; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
Bioorganic & medicinal chemistry letters 2009;19(6):1662-5.
2009: Alfonso Maresca; Claudia Temperini; Hoan Vu; Ngoc B Pham; Sally-Ann Poulsen; Andrea Scozzafava; Ronald J Quinn; Claudiu T Supuran
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.
Journal of the American Chemical Society 2009;131(8):3057-62.
2009: Letizia Crocetti; Alfonso Maresca; Claudia Temperini; Rebecca A Hall; Andrea Scozzafava; Fritz A Mühlschlegel; Claudiu T Supuran
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Bioorganic & medicinal chemistry letters 2009;19(5):1371-5.
2009: Alessio Innocenti; Mika Hilvo; Seppo Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(4):1155-8.
2009: Mika Hilvo; Anna Maria Salzano; Alessio Innocenti; Markku S Kulomaa; Andrea Scozzafava; Andrea Scaloni; Seppo Parkkila; Claudiu T Supuran
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Journal of medicinal chemistry 2009;52(3):646-54.
2009: Semra Isik; Feray Kockar; Meltem Aydin; Oktay Arslan; Ozen Ozensoy Guler; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
Bioorganic & medicinal chemistry 2009;17(3):1158-63.
2009: Anthony Bertucci; Alessio Innocenti; Didier Zoccola; Andrea Scozzafava; Denis Allemand; Sylvie Tambutté; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(3):650-3.
2009: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Bioorganic & medicinal chemistry 2009;17(3):1214-21.
2009: Isao Nishimori; Tomoko Minakuchi; Saburo Onishi; Daniela Vullo; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):70-6.
2009: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.
Journal of medicinal chemistry 2009;52(2):322-8.
2009: Marina P Kolomytseva; Dimetrio Randazzo; Boris P Baskunov; Andrea Scozzafava; Fabrizio Briganti; Ludmila A Golovleva
Role of surfactants in optimizing fluorene assimilation and intermediate formation by Rhodococcus rhodochrous VKM B-2469.
Bioresource technology 2009;100(2):839-44.
2008: Fatma-Zohra Smaine; Fabio Pacchiano; Marouan Rami; Véronique Barragan-Montero; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Bioorganic & medicinal chemistry letters 2008;18(24):6332-5.
2008: Maamar Stiti; Alessandro Cecchi; Marouan Rami; Mohamed Abdaoui; Véronique Barragan-Montero; Andrea Scozzafava; Yannick Guari; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.
Journal of the American Chemical Society 2008;130(48):16130-1.
2008: A Chernykh; N Myasoedova; Marina P Kolomytseva; M Ferraroni; Fabrizio Briganti; Andrea Scozzafava; Ludmila A Golovleva
Laccase isoforms with unusual properties from the basidiomycete Steccherinum ochraceum strain 1833.
Journal of applied microbiology 2008;105(6):2065-75.
2008: Alessio Innocenti; Sabrina A Zimmerman; Andrea Scozzafava; James G Ferry; Claudiu T Supuran
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
Bioorganic & medicinal chemistry letters 2008;18(23):6194-8.
2008: Anne Thiry; Stéphanie Rolin; Daniela Vullo; Aurélie Frankart; Andrea Scozzafava; Jean-Michel Dogné; Johan Wouters; Claudiu T Supuran; Bernard Masereel
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
European journal of medicinal chemistry 2008;43(12):2853-60.
2008: Marouan Rami; Alessandro Cecchi; Jean-Louis Montero; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.
ChemMedChem 2008;3(11):1780-8.
2008: Antonella Gullotto; Sergio Branciamore; Ilaria Duchi; Maria Francisca Pareja Caño; Demetrio Randazzo; Silvia Tilli; Paola Giardina; Giovanni Sannia; Andrea Scozzafava; Fabrizio Briganti
Combined action of a bacterial monooxygenase and a fungal laccase for the biodegradation of mono- and poly-aromatic hydrocarbons.
Bioresource technology 2008;99(17):8353-9.
2008: Ozlen Güzel; Alessio Innocenti; Andrea Scozzafava; Aydin Salman; Seppo Parkkila; Mika Hilvo; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2008;16(20):9113-20.
2008: Mika Hilvo; Lina Baranauskiene; Anna Maria Salzano; Andrea Scaloni; Daumantas Matulis; Alessio Innocenti; Andrea Scozzafava; Simona Maria Monti; Anna Di Fiore; Giuseppina De Simone; Mikaela Lindfors; Janne Jänis; Jarkko Valjakka; Silvia Pastoreková; Jaromir Pastorek; Markku S Kulomaa; Henri R Nordlund; Claudiu T Supuran; Seppo Parkkila
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
The Journal of biological chemistry 2008;283(41):27799-809.
2008: Rebecca A Hall; Daniela Vullo; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran; Peter Klappa; Fritz A Mühlschlegel
External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans.
Molecular and biochemical parasitology 2008;161(2):140-9.
2008: Ilaria Ciullini; Silvia Tilli; Andrea Scozzafava; Fabrizio Briganti
Fungal laccase, cellobiose dehydrogenase, and chemical mediators: combined actions for the decolorization of different classes of textile dyes.
Bioresource technology 2008;99(15):7003-10.
2008: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
Bioorganic & medicinal chemistry 2008;16(18):8373-8.
2008: Alessio Innocenti; Fritz A Mühlschlegel; Rebecca A Hall; Clemens Steegborn; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
Bioorganic & medicinal chemistry letters 2008;18(18):5066-70.
2008: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(15):4282-6.
2008: Daniela Vullo; Isao Nishimori; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2008;18(15):4303-7.
2008: Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Bioorganic & medicinal chemistry 2008;16(15):7424-8.
2008: Irene Matera; Marta Ferraroni; Sibylle Bürger; Andrea Scozzafava; Andreas Stolz; Fabrizio Briganti
Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase.
Journal of molecular biology 2008;380(5):856-68.
2008: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?
Organic & biomolecular chemistry 2008;6(14):2499-506.
2008: Alessio Innocenti; Alfonso Maresca; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
Bioorganic & medicinal chemistry letters 2008;18(14):3938-41.
2008: Alessandro Cecchi; Laura Ciani; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Sandra Ristori; Claudiu T Supuran
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.
Bioorganic & medicinal chemistry letters 2008;18(12):3475-80.
2008: Alessio Innocenti; Mika Hilvo; Andrea Scozzafava; Seppo Parkkila; Claudiu T Supuran
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Bioorganic & medicinal chemistry letters 2008;18(12):3593-6.
2008: Katia D'Ambrosio; Rosa-Maria Vitale; Jean-Michel Dogné; Bernard Masereel; Alessio Innocenti; Andrea Scozzafava; Giuseppina De simone; Claudiu T Supuran
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.
Journal of medicinal chemistry 2008;51(11):3230-7.
2008: Jean-Yves Winum; Marouan Rami; Andrea Scozzafava; Jean-Louis Montero; Claudiu Supuran
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.
Medicinal research reviews 2008;28(3):445-63.
2008: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Bioorganic & medicinal chemistry letters 2008;18(8):2567-73.
2008: Anna Di Fiore; Carlo Pedone; Jochen Antel; Harald Waldeck; Andreas Witte; Michael Wurl; Andrea Scozzafava; Claudiu T Supuran; Giuseppina De simone
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(8):2669-74.
2008: Alessio Innocenti; Andrea Scozzafava; Seppo Parkkila; Luca Puccetti; Giuseppina De Simone; Claudiu T Supuran
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.
Bioorganic & medicinal chemistry letters 2008;18(7):2267-71.
2008: Silvia Pastorekova; Daniela Vullo; Isao Nishimori; Andrea Scozzafava; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
Bioorganic & medicinal chemistry 2008;16(7):3530-6.
2008: Franciszek Saczewski; Alessio Innocenti; Jarosław Sławiński; Anita Kornicka; Zdzislaw Brzozowski; Elzbieta Pomarnacka; Andrea Scozzafava; Claudia Temperini; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Bioorganic & medicinal chemistry 2008;16(7):3933-40.
2008: Alessio Innocenti; Mika Hilvo; Andrea Scozzafava; Mikaela Lindfors; Henri R Nordlund; Markku S Kulomaa; Seppo Parkkila; Claudiu T Supuran
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
Bioorganic & medicinal chemistry letters 2008;18(6):1898-903.
2008: Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).
Bioorganic & medicinal chemistry letters 2008;18(5):1583-7.
2008: Katia D'Ambrosio; Bernard Masereel; Anne Thiry; Andrea Scozzafava; Claudiu T Supuran; Giuseppina De Simone
Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.
ChemMedChem 2008;3(3):473-7.
2008: Gabriela Laura Almajan; Stefania-Felicia Barbuceanu; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols.
Journal of enzyme inhibition and medicinal chemistry 2008;23(1):101-7.
2008: Claudia Temperini; Alessandro Cecchi; Nicholas A Boyle; Andrea Scozzafava; Jaime Escribano Cabeza; Paul Wentworth; G Michael Blackburn; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(3):999-1005.
2008: Marouan Rami; Jean-Yves Winum; Alessio Innocenti; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Bioorganic & medicinal chemistry letters 2008;18(2):836-41.
2008: Saori Morishita; Isao Nishimori; Tomoko Minakuchi; Saburo Onishi; Hiroaki Takeuchi; Tetsuro Sugiura; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori.
Journal of gastroenterology 2008;43(11):849-57.
2008: Claudia Temperini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activation and the drug design.
Current pharmaceutical design 2008;14(7):708-15.
2008: Francesco Mincione; Andrea Scozzafava; Claudiu T Supuran
The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents.
Current pharmaceutical design 2008;14(7):649-54.
2008: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Design of zinc binding functions for carbonic anhydrase inhibitors.
Current pharmaceutical design 2008;14(7):615-21.
2008: Ozlen Güzel; Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Aydin Salman; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(1):152-8.
2007: Isao Nishimori; Tomoko Minakuchi; Saburo Onishi; Daniela Vullo; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Bioorganic & medicinal chemistry 2007;15(23):7229-36.
2007: Isao Nishimori; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.
Bioorganic & medicinal chemistry 2007;15(21):6742-7.
2007: Pedro A Colinas; Rodolfo D Bravo; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(18):5086-90.
2007: Fatma-Zohra Smaine; Jean-Yves Winum; Jean-Louis Montero; Zine Regainia; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.
Bioorganic & medicinal chemistry letters 2007;17(18):5096-100.
2007: Claudia Temperini; Alessio Innocenti; Antonio Mastrolorenzo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(17):4866-72.
2007: vincenzo alterio; Giuseppina De simone; Simona Maria Monti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(15):4201-7.
2007: Daniela Vullo; Alessio Innocenti; Isao Nishimori; Andrea Scozzafava; Kai Kaila; Claudiu T Supuran
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
Bioorganic & medicinal chemistry letters 2007;17(15):4107-12.
2007: Isao Nishimori; Saburo Onishi; Daniela Vullo; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
Bioorganic & medicinal chemistry 2007;15(15):5351-7.
2007: Isao Nishimori; Tomoko Minakuchi; Takuhiro Kohsaki; Saburo Onishi; Hiroaki Takeuchi; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(13):3585-94.
2007: Claudiu T Supuran; Andrea Scozzafava
Carbonic anhydrases as targets for medicinal chemistry.
Bioorganic & medicinal chemistry 2007;15(13):4336-50.
2007: Rosa Maria Vitale; Carlo Pedone; Pietro Amodeo; Jochen Antel; Michael Wurl; Andrea Scozzafava; Claudiu T Supuran; Giuseppina De simone
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.
Bioorganic & medicinal chemistry 2007;15(12):4152-8.
2007: Ludwig Dubois; Kim Douma; Claudiu T Supuran; Roland K Chiu; Marc A M J van Zandvoort; Silvia Pastoreková; Andrea Scozzafava; Bradly G Wouters; Philippe Lambin
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;83(3):367-73.
2007: Jean-Yves Winum; Anne Thiry; Khaled El Cheikh; Jean-Michel Dogné; Jean-Louis Montero; Daniela Vullo; Andrea Scozzafava; Bernard Masereel; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.
Bioorganic & medicinal chemistry letters 2007;17(10):2685-91.
2007: Claudia Temperini; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2795-801.
2007: Claudia Temperini; Alessio Innocenti; Annalisa Guerri; Andrea Scozzafava; Stefano Rusconi; Claudiu T Supuran
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Bioorganic & medicinal chemistry letters 2007;17(8):2210-5.
2007: Elisa Nuti; Elisabetta Orlandini; Susanna Nencetti; Armando Rossello; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Bioorganic & medicinal chemistry 2007;15(6):2298-311.
2007: Alessio Innocenti; Daniela Vullo; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Isao Nishimori; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
Bioorganic & medicinal chemistry letters 2007;17(6):1532-7.
2007: M Amelia Santos; Sergio Marques; Daniela Vullo; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1538-43.
2007: Anna Di Fiore; Andrea Scozzafava; Jean-Yves Winum; Jean-Louis Montero; Carlo Pedone; Claudiu T Supuran; Giuseppina De simone
Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1726-31.
2007: Daniela Vullo; Isao Nishimori; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
Bioorganic & medicinal chemistry letters 2007;17(5):1336-40.
2007: Isao Nishimori; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.
Bioorganic & medicinal chemistry letters 2007;17(4):1037-42.
2007: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
Bioorganic & medicinal chemistry letters 2007;17(3):628-35.
2007: Isao Nishimori; Tomoko Minakuchi; Saburo Onishi; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
Journal of medicinal chemistry 2007;50(2):381-8.
2007: Angela Casini; Guido Mastrobuoni; Claudia Temperini; Chiara Gabbiani; Simona Francese; Gloriano Moneti; Claudiu T Supuran; Andrea Scozzafava; Luigi Messori
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme.
Chemical communications (Cambridge, England) 2007;(2):156-8.
2007: Antonio Mastrolorenzo; Stefano Rusconi; Andrea Scozzafava; Giuseppe Barbaro; Claudiu T Supuran
Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors.
Current medicinal chemistry 2007;14(26):2734-48.
2007: Marta Ferraroni; Nina M Myasoedova; Vadim Schmatchenko; Alexey A Leontievsky; Ludmila A Golovleva; Andrea Scozzafava; Fabrizio Briganti
Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases.
BMC structural biology 2007;7():60.
2007: Stefano Rusconi; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
An update in the development of HIV entry inhibitors.
Current topics in medicinal chemistry 2007;7(13):1273-89.
2007: Francesco Mincione; Andrea Scozzafava; Claudiu T Supuran
The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents.
Current topics in medicinal chemistry 2007;7(9):849-54.
2007: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Metal binding functions in the design of carbonic anhydrase inhibitors.
Current topics in medicinal chemistry 2007;7(9):835-48.
2006: Valeria Menchise; Giuseppina De simone; Anna Di Fiore; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.
Bioorganic & medicinal chemistry letters 2006;16(24):6204-8.
2006: Jean-Yves Winum; Claudia Temperini; Khaled El Cheikh; Alessio Innocenti; Daniela Vullo; Samuele Ciattini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
Journal of medicinal chemistry 2006;49(24):7024-31.
2006: Alexander Weber; Markus Böhm; Claudiu T Supuran; Andrea Scozzafava; Christoph A Sotriffer; Gerhard Klebe
3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors.
Journal of chemical information and modeling 2006;46(6):2737-60.
2006: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Therapeutic potential of sulfamides as enzyme inhibitors.
Medicinal research reviews 2006;26(6):767-92.
2006: Franciszek Saczewski; Alessio Innocenti; Zdzislaw Brzozowski; Jarosław Slawiński; Elzbieta Pomarnacka; Anita Kornicka; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2006;21(5):563-8.
2006: Claudia Temperini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.
Bioorganic & medicinal chemistry letters 2006;16(19):5152-6.
2006: Claudia Temperini; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(27):7057-66.
2006: Franciszek Saczewski; Jarosław Sławiński; Anita Kornicka; Zdzislaw Brzozowski; Elzbieta Pomarnacka; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.
Bioorganic & medicinal chemistry letters 2006;16(18):4846-51.
2006: Giuseppina De simone; Rosa Maria Vitale; Anna Di Fiore; Carlo Pedone; Andrea Scozzafava; Jean-Louis Montero; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
Journal of medicinal chemistry 2006;49(18):5544-51.
2006: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4316-20.
2006: Jean-Yves Winum; Alessandro Cecchi; Achour Seridi; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides--a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):477-81.
2006: Muhammad Zareef; Alessio Innocenti; Rashid Iqbal; Javid H Zaidi; Muhammad Arfan; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):351-9.
2006: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.
Mini reviews in medicinal chemistry 2006;6(8):921-36.
2006: Seppo Parkkila; Daniela Vullo; Luca Puccetti; Anna-Kaisa Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
Bioorganic & medicinal chemistry letters 2006;16(15):3955-9.
2006: Marta Ferraroni; Marina P Kolomytseva; Inna P Solyanikova; Andrea Scozzafava; Ludmila A Golovleva; Fabrizio Briganti
Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.
Journal of molecular biology 2006;360(4):788-99.
2006: vincenzo alterio; Rosa Maria Vitale; Simona Maria Monti; Carlo Pedone; Andrea Scozzafava; Alessandro Cecchi; Giuseppina De simone; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
Journal of the American Chemical Society 2006;128(25):8329-35.
2006: Daniela Vullo; Eva Ruusuvuori; Kai Kaila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Bioorganic & medicinal chemistry letters 2006;16(12):3139-43.
2006: Claudia Temperini; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
Journal of medicinal chemistry 2006;49(10):3019-27.
2006: Isao Nishimori; Daniela Vullo; Tomoko Minakuchi; Kaori Morimoto; Saburo Onishi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
Bioorganic & medicinal chemistry letters 2006;16(8):2182-8.
2006: Daniela Vullo; Bente Steffansen; Birger Brodin; Claudiu T Supuran; Andrea Scozzafava; Carsten Uhd Nielsen
Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.
Bioorganic & medicinal chemistry 2006;14(7):2418-27.
2006: Isao Nishimori; Tomoko Minakuchi; Kaori Morimoto; Shuichi Sano; Saburo Onishi; Hiroaki Takeuchi; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
Journal of medicinal chemistry 2006;49(6):2117-26.
2006: Anna Di Fiore; Carlo Pedone; Katia D'Ambrosio; Andrea Scozzafava; Giuseppina De simone; Claudiu T Supuran
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.
Bioorganic & medicinal chemistry letters 2006;16(2):437-42.
2006: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
The sulfamide motif in the design of enzyme inhibitors.
Expert opinion on therapeutic patents 2006;16(1):27-47.
2006: Claudiu T Supuran; Antonio Mastrolorenzo; Giuseppe Barbaro; Andrea Scozzafava
Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles.
Current pharmaceutical design 2006;12(27):3459-65.
2005: Isao Nishimori; Daniela Vullo; Alessio Innocenti; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
Journal of medicinal chemistry 2005;48(24):7860-6.
2005: Claudia Temperini; Andrea Scozzafava; Luca Puccetti; Claudiu T Supuran
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.
Bioorganic & medicinal chemistry letters 2005;15(23):5136-41.
2005: Alessandro Cecchi; Scott D Taylor; Yong Liu; Bryan Hill; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(23):5192-6.
2005: Ozen Ozensoy; Isao Nishimori; Daniela Vullo; Luca Puccetti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides.
Bioorganic & medicinal chemistry 2005;13(22):6089-93.
2005: Ozen Ozensoy; Luca Puccetti; Giuseppe Fasolis; Oktay Arslan; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(21):4862-6.
2005: Alessio Innocenti; Raquel Villar; Victor Martinez-Merino; María J Gil; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(21):4872-6.
2005: Valeria Menchise; Giuseppina De simone; vincenzo alterio; Anna Di Fiore; Carlo Pedone; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.
Journal of medicinal chemistry 2005;48(18):5721-7.
2005: Francesco Mincione; Michele Starnotti; Emanuela Masini; Lucia Bacciottini; Chiara Scrivanti; Angela Casini; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Bioorganic & medicinal chemistry letters 2005;15(17):3821-7.
2005: Isao Nishimori; Daniela Vullo; Alessio Innocenti; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(17):3828-33.
2005: Ozen Ozensoy; Semra Isik; Oktay Arslan; Mikail Arslan; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(4):383-7.
2005: Alessandro Cecchi; Alzbeta Hulikova; Jaromir Pastorek; Silvia Pastoreková; Andrea Scozzafava; Jean-Yves Winum; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Journal of medicinal chemistry 2005;48(15):4834-41.
2005: Jean-Yves Winum; Alessandro Cecchi; Jean-Louis Montero; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.
Bioorganic & medicinal chemistry letters 2005;15(13):3302-6.
2005: Luca Puccetti; Giuseppe Fasolis; Daniela Vullo; Zahid H Chohan; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.
Bioorganic & medicinal chemistry letters 2005;15(12):3096-101.
2005: Vladimir Garaj; Luca Puccetti; Giuseppe Fasolis; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Bioorganic & medicinal chemistry letters 2005;15(12):3102-8.
2005: Marta Ferraroni; Jana Seifert; Vasili M Travkin; Monika Thiel; Stefan R Kaschabek; Andrea Scozzafava; Ludmila A Golovleva; Michael Schlömann; Fabrizio Briganti
Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation.
The Journal of biological chemistry 2005;280(22):21144-54.
2005: Zahid H Chohan; Claudiu T Supuran; Andrea Scozzafava
Metal binding and antibacterial activity of ciprofloxacin complexes.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):303-7.
2005: Silvia Pastorekova; Daniela Vullo; Angela Casini; Andrea Scozzafava; Jaromir Pastorek; Isao Nishimori; Claudiu T Supuran
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):211-7.
2005: Luca Puccetti; Giuseppe Fasolis; Alessandro Cecchi; Jean-Yves Winum; Alessandro Gamberi; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Bioorganic & medicinal chemistry letters 2005;15(9):2359-64.
2005: Jean-Yves Winum; Alessio Innocenti; Jihane Nasr; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(9):2353-8.
2005: Gabriela Laura Almajan; Alessio Innocenti; Luca Puccetti; Gheorghe Manole; Stefania Barbuceanu; Ioana Saramet; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.
Bioorganic & medicinal chemistry letters 2005;15(9):2347-52.
2005: Giuseppina De simone; Anna Di Fiore; Valeria Menchise; Carlo Pedone; Jochen Antel; Angela Casini; Andrea Scozzafava; Michael Wurl; Claudiu T Supuran
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2005;15(9):2315-20.
2005: Anna Di Fiore; Giuseppina De simone; Valeria Menchise; Carlo Pedone; Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.
Bioorganic & medicinal chemistry letters 2005;15(7):1937-42.
2005: Alessio Innocenti; Jochen Antel; Michael Wurl; Daniela Vullo; Michael A Firnges; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
Bioorganic & medicinal chemistry letters 2005;15(7):1909-13.
2005: Jean-Yves Winum; Jean-Michel Dogné; Angela Casini; Xavier de Leval; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Journal of medicinal chemistry 2005;48(6):2121-5.
2005: Jean-Yves Winum; Alessio Innocenti; Valérie Gagnard; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.
Bioorganic & medicinal chemistry letters 2005;15(6):1683-6.
2005: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Sulfamates and their therapeutic potential.
Medicinal research reviews 2005;25(2):186-228.
2005: Alessio Innocenti; Michael A Firnges; Jochen Antel; Michael Wurl; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(4):1149-54.
2005: Daniela Vullo; Juha Voipio; Alessio Innocenti; Claudio Rivera; Harri Ranki; Andrea Scozzafava; Kai Kaila; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(4):971-6.
2005: Daniela Vullo; Alessio Innocenti; Isao Nishimori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastoreková; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Bioorganic & medicinal chemistry letters 2005;15(4):963-9.
2005: Marta Ferraroni; Ilaria Duchi; Nina M Myasoedova; Alexey A Leontievsky; Ludmila A Golovleva; Andrea Scozzafava; Fabrizio Briganti
Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):205-7.
2005: Jean-Yves Winum; Silvia Pastorekova; Lydia Jakubickova; Jean-Louis Montero; Andrea Scozzafava; Jaromir Pastorek; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Bioorganic & medicinal chemistry letters 2005;15(3):579-84.
2005: Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Joseph R Casey; Claudiut Supuran
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.
Bioorganic & medicinal chemistry letters 2005;15(3):573-8.
2005: Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
Bioorganic & medicinal chemistry letters 2005;15(3):567-71.
2005: Hasan Turkmen; Mustafa Durgun; Serpil Yilmaztekin; Mahmut Emul; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2005;15(2):367-72.
2005: Jerapan Krungkrai; Andrea Scozzafava; Sutarnthip Reungprapavut; Sudaratana R Krungkrai; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?
Bioorganic & medicinal chemistry 2005;13(2):483-9.
2005: Giuseppe Barbaro; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome.
Current pharmaceutical design 2005;11(14):1805-43.
2004: Sabrina Zimmerman; Alessio Innocenti; Angela Casini; James G Ferry; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(24):6001-6.
2004: Celine Chazalette; Bernard Masereel; Stéphanie Rolin; Anne Thiry; Andrea Scozzafava; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.
Bioorganic & medicinal chemistry letters 2004;14(23):5781-6.
2004: Alessandro Cecchi; Jean-Yves Winum; Alessio Innocenti; Daniela Vullo; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.
Bioorganic & medicinal chemistry letters 2004;14(23):5775-80.
2004: Alessio Innocenti; Michael A Firnges; Jochen Antel; Michael Wurl; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
Bioorganic & medicinal chemistry letters 2004;14(23):5769-73.
2004: Stefano Rusconi; Alessio Innocenti; Daniela Vullo; Antonio Mastrolorenzo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.
Bioorganic & medicinal chemistry letters 2004;14(23):5763-7.
2004: Stefano Rusconi; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
New advances in HIV entry inhibitors development.
Current drug targets. Infectious disorders 2004;4(4):339-55.
2004: Eliska Svastová; Alzbeta Hulíková; Monika Rafajová; Miriam Zat'ovicová; Adriana Gibadulinová; Angela Casini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran; Jaromir Pastorek; Silvia Pastoreková
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
FEBS letters 2004;577(3):439-45.
2004: Alessio Innocenti; Jochen Antel; Michael Wurl; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Bioorganic & medicinal chemistry letters 2004;14(22):5703-7.
2004: Alessio Innocenti; Jonna M Lehtonen; Seppo Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
Bioorganic & medicinal chemistry letters 2004;14(21):5435-9.
2004: Vladimir Garaj; Luca Puccetti; Giuseppe Fasolis; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.
Bioorganic & medicinal chemistry letters 2004;14(21):5427-33.
2004: Alessio Innocenti; Angela Casini; Maria Claudia Alcaro; Anna Maria Papini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.
Journal of medicinal chemistry 2004;47(21):5224-9.
2004: Alessio Innocenti; Sabrina Zimmerman; James G Ferry; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
Bioorganic & medicinal chemistry letters 2004;14(17):4563-7.
2004: Claudiu T Supuran; Angela Casini; Antonio Mastrolorenzo; Andrea Scozzafava
COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.
Mini reviews in medicinal chemistry 2004;4(6):625-32.
2004: Jonna M Lehtonen; Seppo Parkkila; Daniela Vullo; Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Bioorganic & medicinal chemistry letters 2004;14(14):3757-62.
2004: Marta Ferraroni; Inna P Solyanikova; Marina P Kolomytseva; Andrea Scozzafava; Ludmila A Golovleva; Fabrizio Briganti
Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP.
The Journal of biological chemistry 2004;279(26):27646-55.
2004: Alessio Innocenti; Sabrina Zimmerman; James G Ferry; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt gamma-class enzyme from the archaeon Methanosarcina thermophila with anions.
Bioorganic & medicinal chemistry letters 2004;14(12):3327-31.
2004: Mona Jaiswal; Padmakar V Khadikar; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(12):3283-90.
2004: Sergio Antonio Tripodi; Maria Teresa del Vecchio; Claudiu T Supuran; Andrea Scozzafava; M Gabriella Gabrielli; Silvia Pastorekova; Ranieri Rossie; Giuseppe Fasolis; Luca Puccetti
Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):287-91.
2004: Laurent Bonnac; Alessio Innocenti; Jean-Yves Winum; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Veronique Barragan; Claudiu T Supuran
Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):275-8.
2004: Claudiu T Supuran; Andrea Scozzafava
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):269-73.
2004: Zahid H Chohan; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):263-7.
2004: Xavier de Leval; Monica Ilies; Angela Casini; Jean-Michel Dogné; Andrea Scozzafava; Emanuela Masini; Francesco Mincione; Michele Starnotti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Journal of medicinal chemistry 2004;47(11):2796-804.
2004: Marc A Ilies; Bernard Masereel; Stéphanie Rolin; Andrea Scozzafava; Gheorghe Câmpeanu; Valentin Cîmpeanu; Claudiu T Supuran
Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.
Bioorganic & medicinal chemistry 2004;12(10):2717-26.
2004: Francesco Abbate; Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide.
Bioorganic & medicinal chemistry letters 2004;14(9):2357-61.
2004: Daniela Vullo; Andrea Scozzafava; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Bioorganic & medicinal chemistry letters 2004;14(9):2351-6.
2004: Joseph R Casey; Patricio E Morgan; Daniela Vullo; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.
Journal of medicinal chemistry 2004;47(9):2337-47.
2004: Daniela Vullo; Marco Franchi; Enzo Gallori; Jochen Antel; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.
Journal of medicinal chemistry 2004;47(5):1272-9.
2004: Silvia Pastorekova; Angela Casini; Andrea Scozzafava; Daniela Vullo; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(4):869-73.
2004: Zahid H Chohan; Claudiu T Supuran; Andrea Scozzafava
Metalloantibiotics: synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):79-84.
2004: Claudiu T Supuran; Alessio Innocenti; Antonio Mastrolorenzo; Andrea Scozzafava
Antiviral sulfonamide derivatives.
Mini reviews in medicinal chemistry 2004;4(2):189-200.
2004: Alexander Weber; Angela Casini; Andreas Heine; Daniel Kuhn; Claudiu T Supuran; Andrea Scozzafava; Gerhard Klebe
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
Journal of medicinal chemistry 2004;47(3):550-7.
2004: Jonna Lehtonen; bairong shen; Mauno Vihinen; Angela Casini; Andrea Scozzafava; Claudiu T Supuran; Anna-Kaisa Parkkila; Juha Saarnio; Aarre Kivelä; Abdul Waheed; William S Sly; Seppo Parkkila
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
The Journal of biological chemistry 2004;279(4):2719-27.
2004: Francesco Abbate; Anita Coetzee; Angela Casini; Samuele Ciattini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.
Bioorganic & medicinal chemistry letters 2004;14(2):337-41.
2004: Francesco Abbate; Jean-Yves Winum; Barry V L Potter; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.
Bioorganic & medicinal chemistry letters 2004;14(1):231-4.
2004: Jean-Yves Winum; Angela Casini; Francesco Mincione; Michele Starnotti; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Bioorganic & medicinal chemistry letters 2004;14(1):225-9.
2004: Francesco Abbate; Angela Casini; Takashi Owa; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(1):217-23.
2004: Demetrio Randazzo; Marta Ferraroni; Andrea Scozzafava; Ludmila A Golovleva; Fabrizio Briganti
Biotransformation of chloroaromatics: the impact of bioavailability and substrate specificity.
Bioinorganic chemistry and applications 2004;():209-23.
2004: Claudiu T Supuran; Daniela Vullo; Gheorghe Manole; Angela Casini; Andrea Scozzafava
Designing of novel carbonic anhydrase inhibitors and activators.
Current medicinal chemistry. Cardiovascular and hematological agents 2004;2(1):49-68.
2003: Jean-Yves Winum; Daniela Vullo; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Journal of medicinal chemistry 2003;46(25):5471-7.
2003: Daniela Vullo; Marco Franchi; Enzo Gallori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):403-6.
2003: Antonio Mastrolorenzo; Giuliano Zuccati; Daniela Massi; Maria G Gabrielli; Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Immunohistochemical study of carbonic anhydrase isozymes in human skin.
European journal of dermatology : EJD 2003;13(5):440-4.
2003: Angela Casini; Andrea Scozzafava; Francesco Mincione; Luca Menabuoni; Michele Starnotti; Claudiu T Supuran
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
Bioorganic & medicinal chemistry letters 2003;13(17):2867-73.
2003: Marco Franchi; Daniela Vullo; Enzo Gallori; Jochen Antel; Michael Wurl; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions.
Bioorganic & medicinal chemistry letters 2003;13(17):2857-61.
2003: Claudiu T Supuran; Angela Casini; Andrea Scozzafava
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
Medicinal research reviews 2003;23(5):535-58.
2003: Angela Casini; Silvio Caccia; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II.
Bioorganic & medicinal chemistry letters 2003;13(16):2765-8.
2003: Angela Casini; Francesco Abbate; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?
Bioorganic & medicinal chemistry letters 2003;13(16):2759-63.
2003: Giuseppina De simone; Valeria Menchise; Salvatore Omaggio; Carlo Pedone; Andrea Scozzafava; Claudiu T Supuran
Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
Biochemistry 2003;42(30):9013-21.
2003: Marco Franchi; Daniela Vullo; Enzo Gallori; Jaromir Pastorek; Antonella Russo; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):333-8.
2003: Francesco Abbate; Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):303-8.
2003: Andrea Bencini; Eckhard Bill; Andrea Scozzafava; Federico Totti
Density functional characterization of the chemoselective oxidation of catechol by using molecular oxygen: thermodynamics of the reaction between [(triphos)Ir(dtbc)]+ and O2.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(13):3015-23.
2003: Zahid H Chohan; Andrea Scozzafava; Claudiu T Supuran
Zinc complexes of benzothiazole-derived Schiff bases with antibacterial activity.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):259-63.
2003: M Amélia Santos; Sérgio Marques; Marco Gil; Matteo Tegoni; Andrea Scozzafava; Claudiu T Supuran
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):233-42.
2003: Andrea Scozzafava; Takashi Owa; Antonio Mastrolorenzo; Claudiu T Supuran
Anticancer and antiviral sulfonamides.
Current medicinal chemistry 2003;10(11):925-53.
2003: Jean-Yves Winum; Daniela Vullo; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(11):2197-204.
2003: Monica Ilies; Daniela Vullo; Jaromir Pastorek; Andrea Scozzafava; Marc A Ilies; Miron T Caproiu; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Journal of medicinal chemistry 2003;46(11):2187-96.
2003: Andrea Scozzafava; Claudiu T Supuran
Hydroxyurea is a carbonic anhydrase inhibitor.
Bioorganic & medicinal chemistry 2003;11(10):2241-6.
2003: Monica Ilies; Mircea D Banciu; Andrea Scozzafava; Marc A Ilies; Miron T Caproiu; Claudiu T Supuran
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.
Bioorganic & medicinal chemistry 2003;11(10):2227-39.
2003: Daniela Vullo; Marco Franchi; Enzo Gallori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2003;13(6):1005-9.
2003: Angela Casini; Jochen Antel; Francesco Abbate; Andrea Scozzafava; Samuel David; Harald Waldeck; Siegfried Schäfer; Claudiu T Supuran
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
Bioorganic & medicinal chemistry letters 2003;13(5):841-5.
2003: Angela Casini; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
Bioorganic & medicinal chemistry letters 2003;13(5):837-40.
2003: Claudiu T Supuran; Andrea Scozzafava; Angela Casini
Carbonic anhydrase inhibitors.
Medicinal research reviews 2003;23(2):146-89.
2003: Marta Ferraroni; Maria Yolanda Ruiz Tarifa; Andrea Scozzafava; Inna P Solyanikova; Marina P Kolomytseva; Ludmila A Golovleva; Fabrizio Briganti
Preliminary crystallographic analysis of 3-chlorocatechol 1,2-dioxygenase of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):188-90.
2002: Andrea Scozzafava; Claudiu T Supuran
Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.
Bioorganic & medicinal chemistry letters 2002;12(19):2667-72.
2002: Angela Casini; Andrea Scozzafava; Francesco Mincione; Luca Menabuoni; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis of water soluble sulfonamides incorporating a 4-sulfamoylphenylmethylthiourea scaffold, with potent intraocular pressure lowering properties.
Journal of enzyme inhibition and medicinal chemistry 2002;17(5):333-43.
2002: Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs.
Environmental health perspectives 2002;110 Suppl 5():801-6.
2002: Francesca Maestrelli; Paola Mura; Angela Casini; Francesco Mincione; Andrea Scozzafava; Claudiu T Supuran
Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents.
Journal of pharmaceutical sciences 2002;91(10):2211-9.
2002: Carsten Uhd Nielsen; Claudiu T Supuran; Andrea Scozzafava; Sven Frokjaer; Bente Steffansen; Birger Brodin
Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line.
Pharmaceutical research 2002;19(9):1337-44.
2002: Francesco Abbate; Claudiu T Supuran; Andrea Scozzafava; Pierluigi Orioli; Milton T Stubbs; Gerhard Klebe
Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.
Journal of medicinal chemistry 2002;45(17):3583-7.
2002: Zahid H Chohan; Andrea Scozzafava; Claudiu T Supuran
Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties.
Journal of enzyme inhibition and medicinal chemistry 2002;17(4):261-6.
2002: Claudiu T Supuran; Andrea Scozzafava; Brian W Clare
Bacterial protease inhibitors.
Medicinal research reviews 2002;22(4):329-72.
2002: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.
Bioorganic & medicinal chemistry letters 2002;12(12):1551-7.
2002: Andrea Scozzafava; Angela Casini; Claudiu T Supuran
Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs.
Current medicinal chemistry 2002;9(12):1167-85.
2002: Marta Ferraroni; Maria Yolanda Ruiz Tarifa; Fabrizio Briganti; Andrea Scozzafava; Stefano Mangani; Inna P Solyanikova; Marina P Kolomytseva; Ludmila A Golovleva
4-Chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: crystallization and preliminary crystallographic analysis.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1074-6.
2002: Marta Ferraroni; Silvia Tilli; Fabrizio Briganti; W Richard Chegwidden; Claudiu T Supuran; Karin E Wiebauer; Richard E Tashian; Andrea Scozzafava
Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.
Biochemistry 2002;41(20):6237-44.
2002: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.
Bioorganic & medicinal chemistry letters 2002;12(8):1177-80.
2002: Zahid H Chohan; Humayun Pervez; Abdul Rauf; Andrea Scozzafava; Claudiu T Supuran
Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):117-22.
2002: Zahid H Chohan; Abdul Rau; Sobia Noreen; Andrea Scozzafava; Claudiu T Supuran
Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):101-6.
2002: Zahid H Chohan; Mohammad S Iqbal; Hummara Sadia Iqbal; Andrea Scozzafava; Claudiu T Supuran
Transition metal acetylsalicylates and their anti-inflammatory activity.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):87-91.
2002: Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):69-76.
2002: Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Journal of medicinal chemistry 2002;45(7):1466-76.
2002: Angela Casini; Andrea Scozzafava; Antonio Mastrolorenzo; Laudiu T Supuran
Sulfonamides and sulfonylated derivatives as anticancer agents.
Current cancer drug targets 2002;2(1):55-75.
2002: Angela Casini; Francesco Mincione; Daniela Vullo; Luca Menabuoni; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold.
Journal of enzyme inhibition and medicinal chemistry 2002;17(1):9-18.
2002: Zahid H Chohan; M A Farooq; Andrea Scozzafava; Claudiu T Supuran
Antibacterial Schiff bases of oxalyl-hydrazine/diamide incorporating pyrrolyl and salicylyl moieties and of their zinc(II) complexes.
Journal of enzyme inhibition and medicinal chemistry 2002;17(1):1-7.
2002: Marc A Ilies; Mircea D Banciu; Monica Ilies; Andrea Scozzafava; Miron T Caproiu; Claudiu T Supuran
Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.
Journal of medicinal chemistry 2002;45(2):504-10.
2002: Bernard Masereel; Stéphanie Rolin; Francesco Abbate; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
Journal of medicinal chemistry 2002;45(2):312-20.
2002: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.
Journal of medicinal chemistry 2002;45(2):284-91.
2001: M Ul-Hassan; Andrea Scozzafava; Zahid H Chohan; Claudiu T Supuran
Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 2001;16(6):499-505.
2001: Andrea Scozzafava; A Mastrolorenzo; Claudiu T Supuran
Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives.
Journal of enzyme inhibition 2001;16(5):425-32.
2001: Andrea Scozzafava; I Saramet; Mircea D Banciu; Claudiu T Supuran
Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.
Journal of enzyme inhibition 2001;16(4):351-8.
2001: D Randazzo; Debora Berti; Fabrizio Briganti; Piero Baglioni; Andrea Scozzafava; Patrizia Di Gennaro; Enrica Galli; Giuseppina Bestetti
Efficient polycyclic aromatic hydrocarbons dihydroxylation in direct micellar systems.
Biotechnology and bioengineering 2001;74(3):240-8.
2001: Francesco Mincione; Michele Starnotti; Luca Menabuoni; Andrea Scozzafava; Angela Casini; Claudiu T Supuran
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.
Bioorganic & medicinal chemistry letters 2001;11(13):1787-91.
2001: Andrea Scozzafava; A Mastrolorenzo; Claudiu T Supuran
Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.
Bioorganic & medicinal chemistry letters 2001;11(13):1675-8.
2001: Claudiu T Supuran; Fabrizio Briganti; Silvia Tilli; W Richard Chegwidden; Andrea Scozzafava
Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?
Bioorganic & medicinal chemistry 2001;9(3):703-14.
2001: Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; G Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
Bioorganic & medicinal chemistry letters 2001;11(4):575-82.
2001: Andrea Scozzafava; Francesco Mincione; Luca Menabuoni; Claudiu T Supuran
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating phthaloyl and phthalimido moieties.
Drug design and discovery 2001;17(4):337-48.
2001: Andrea Scozzafava; A Mastrolorenzo; Claudiu T Supuran
Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin?
Journal of enzyme inhibition 2001;16(1):55-63.
2001: Angela Casini; Francesco Mincione; Marc A Ilies; Luca Menabuoni; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties.
Journal of enzyme inhibition 2001;16(2):113-23.
2000: Angela Casini; Andrea Scozzafava; Francesco Mincione; Luca Menabuoni; Marc A Ilies; Claudiu T Supuran
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Journal of medicinal chemistry 2000;43(25):4884-92.
2000: Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Fabrizio Briganti; G Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Journal of medicinal chemistry 2000;43(23):4542-51.
2000: Fabrizio Briganti; Enrica Pessione; Carlo Giunta; Roberto Mazzoli; Andrea Scozzafava
Purification and catalytic properties of two catechol 1,2-dioxygenase isozymes from benzoate-grown cells of Acinetobacter radioresistens.
Journal of protein chemistry 2000;19(8):709-16.
2000: A Guerri; Fabrizio Briganti; Andrea Scozzafava; C T Supuran; Stefano Mangani
Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.
Biochemistry 2000;39(40):12391-7.
2000: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Journal of medicinal chemistry 2000;43(20):3677-87.
2000: Andrea Scozzafava; A Mastrolorenzo; Claudiu T Supuran
Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents.
Bioorganic & medicinal chemistry letters 2000;10(16):1887-91.
2000: Monica Ilies; Claudiu T Supuran; Andrea Scozzafava; Angela Casini; Francesco Mincione; Luca Menabuoni; Miron T Caproiu; M Maganu; Mircea D Banciu
Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions.
Bioorganic & medicinal chemistry 2000;8(8):2145-55.
2000: Andrea Scozzafava; Marc A Ilies; G Manole; Claudiu T Supuran
Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-beta-alanine hydroxamate moieties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11(1):69-79.
2000: Andrea Scozzafava; Claudiu T Supuran
Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Journal of medicinal chemistry 2000;43(9):1858-65.
2000: Claudiu T Supuran; Andrea Scozzafava; Fabrizio Briganti; BW Clare
Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.
Journal of medicinal chemistry 2000;43(9):1793-806.
2000: Andrea Bencini; E Bill; F Mariotti; Federico Totti; Andrea Scozzafava; A Vargas
Density functional description of the early stages of the dioxygenation of [(MeC(CH2PPh2)3)M(catecholate)]+ complexes [M = Co(III), Ir(III)]: toward a rationalization of the catalytic mechanism of ring-opening dioxygenases.
Inorganic chemistry 2000;39(7):1418-25.
2000: Debora Berti; D Randazzo; Fabrizio Briganti; Piero Baglioni; Andrea Scozzafava; Patrizia Di Gennaro; Enrica Galli; Giuseppina Bestetti
Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production.
Journal of inorganic biochemistry 2000;79(1-4):103-8.
2000: Andrea Scozzafava; Claudiu T Supuran
Protease inhibitors: synthesis of clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties.
Bioorganic & medicinal chemistry letters 2000;10(5):499-502.
2000: Claudiu T Supuran; Fabrizio Briganti; Luca Menabuoni; G Mincione; Francesco Mincione; Andrea Scozzafava
Carbonic anhydrase inhibitors - part 78(#). Synthesis of water-soluble sulfonamides incorporating beta-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route.
European journal of medicinal chemistry 2000;35(3):309-21.
2000: Andrea Scozzafava; Claudiu T Supuran
Protease inhibitors - part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase.
European journal of medicinal chemistry 2000;35(3):299-307.
2000: Andrea Scozzafava; Claudiu T Supuran
Protease inhibitors. Part 8: synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties.
Bioorganic & medicinal chemistry 2000;8(3):637-45.
2000: Claudiu T Supuran; Andrea Scozzafava
Protease inhibitors. Part 7. Inhibition of Clostridium histolyticum collagenase with sulfonylated derivatives of L-valine hydroxamate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(1):67-76.
2000: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(1):29-41.
2000: Andrea Scozzafava; Fabrizio Briganti; Marc A Ilies; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Journal of medicinal chemistry 2000;43(2):292-300.
2000: Marc A Ilies; Claudiu T Supuran; Andrea Scozzafava
Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances.
Metal-based drugs 2000;7(2):57-62.
2000: Claudiu T Supuran; Andrea Scozzafava
Activation of carbonic anhydrase isozymes.
EXS 2000;(90):197-219.
2000: Claudiu T Supuran; Andrea Scozzafava
Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors.
Journal of enzyme inhibition 2000;15(6):597-610.
2000: Andrea Scozzafava; Mircea D Banciu; A Popescu; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis of Schiff bases of hydroxybenzaldehydes with aromatic sulfonamides and their reactions with arylsulfonyl isocyanates.
Journal of enzyme inhibition 2000;15(6):533-46.
2000: Claudiu T Supuran; Andrea Scozzafava
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole.
Journal of enzyme inhibition 2000;15(5):471-86.
2000: Andrea Scozzafava; Mircea D Banciu; A Popescu; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives.
Journal of enzyme inhibition 2000;15(5):443-53.
2000: Claudiu T Supuran; Andrea Scozzafava; Marc A Ilies; Fabrizio Briganti
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes.
Journal of enzyme inhibition 2000;15(4):381-401.
2000: Claudiu T Supuran; Fabrizio Briganti; Andrea Scozzafava; Marc A Ilies
Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.
Journal of enzyme inhibition 2000;15(4):335-56.
2000: Andrea Scozzafava; B Iorga; Claudiu T Supuran
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives).
Journal of enzyme inhibition 2000;15(2):139-61.
2000: Claudiu T Supuran; Fabrizio Briganti; G Mincione; Andrea Scozzafava
Protease inhibitors: Synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of clostridium histolyticum collagenase.
Journal of enzyme inhibition 2000;15(2):111-28.
2000: M Barboiu; Claudiu T Supuran; Luca Menabuoni; Andrea Scozzafava; Francesco Mincione; Fabrizio Briganti; G Mincione
Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide.
Journal of enzyme inhibition 2000;15(1):23-46.
2000: BW Clare; Andrea Scozzafava; Fabrizio Briganti; B Iorga; Claudiu T Supuran
Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations.
Journal of enzyme inhibition 2000;15(3):235-64.
2000: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators - part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties.
European journal of medicinal chemistry 2000;35(1):31-9.
1999: Claudiu T Supuran; Andrea Scozzafava
Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators.
Bioorganic & medicinal chemistry 1999;7(12):2915-23.
1999: G Mincione; Luca Menabuoni; Fabrizio Briganti; Francesco Mincione; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Part 79. Synthesis of topically acting sulfonamides incorporating GABA moieties in their molecule, with long-lasting intraocular pressure-lowering properties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;9(2):185-99.
1999: J Borras; Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Fabrizio Briganti; G Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties: is the tail more important than the ring?
Bioorganic & medicinal chemistry 1999;7(11):2397-406.
1999: Andrea Scozzafava; Fabrizio Briganti; G Mincione; Luca Menabuoni; Francesco Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Journal of medicinal chemistry 1999;42(18):3690-700.
1999: Claudiu T Supuran; Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Fabrizio Briganti; G Mincione
Carbonic anhydrase inhibitors. Part 71. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering sulfonamides incorporating picolinoyl moieties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;8(4):317-28.
1999: Fabrizio Briganti; Andrea Scozzafava; Claudiu T Supuran
Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties.
Bioorganic & medicinal chemistry letters 1999;9(14):2043-8.
1999: Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Fabrizio Briganti; G Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Journal of medicinal chemistry 1999;42(14):2641-50.
1999: Claudiu T Supuran; Andrea Scozzafava; Francesco Mincione; Luca Menabuoni; Fabrizio Briganti; G Mincione; M Jitianu
Carbonic anhydrase inhibitors. Part 60(#). The topical intraocular pressure-lowering properties of metal complexes of a heterocyclic sulfonamide: influence of the metal ion upon biological activity.
European journal of medicinal chemistry 1999;34(7-8):585-95.
1999: Manuela Benvenuti; Fabrizio Briganti; Andrea Scozzafava; Ludmila A Golovleva; Vasili M Travkin; Stefano Mangani
Crystallization and preliminary crystallographic analysis of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E: a novel dioxygenase involved in the biodegradation of polychlorinated aromatic compounds.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 4):901-3.
1999: Luca Menabuoni; Andrea Scozzafava; Francesco Mincione; Fabrizio Briganti; G Mincione; Claudiu T Supuran
Carbonic anhydrase inhibitors. Water-soluble, topically effective intraocular pressure lowering agents derived from isonicotinic acid and aromatic/heterocyclic sulfonamides: is the tail more important than the ring?
Journal of enzyme inhibition 1999;14(6):457-74.
1999: A Popescu; A Simion; Andrea Scozzafava; Fabrizio Briganti; Claudiu T Supuran
Carbonic anhydrase inhibitors. Schiff bases of some aromatic sulfonamides and their metal complexes: towards more selective inhibitors of carbonic anhydrase isozyme IV.
Journal of enzyme inhibition 1999;14(6):407-23.
1999: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Arylsulfonylureido- and arylureido-substituted aromatic and heterocyclic sulfonamides: towards selective inhibitors of carbonic anhydrase isozyme I.
Journal of enzyme inhibition 1999;14(5):343-63.
1999: Claudiu T Supuran; Andrea Scozzafava; Fabrizio Briganti
Carbonic anhydrase inhibitors: N-cyanosulfonamides, a new class of high affinity isozyme II and IV inhibitors.
Journal of enzyme inhibition 1999;14(4):289-306.
1998: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: novel compounds containing S-NH moieties: sulfenamido-sulfonamides, sulfenimido-sulfonamides and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 1998;13(6):419-42.
1998: Fabrizio Briganti; Stefano Mangani; L Pedocchi; Andrea Scozzafava; Ludmila A Golovleva; AP Jadan; Inna P Solyanikova
XAS characterization of the active sites of novel intradiol ring-cleaving dioxygenases: hydroxyquinol and chlorocatechol dioxygenases.
FEBS letters 1998;433(1-2):58-62.
1998: Claudiu T Supuran; Andrea Scozzafava; Fabrizio Briganti; G Loloiu; O Maior
Sulfonylamido derivatives of 2-aminophenoxathiin-10,10-dioxide and related compounds possess antifungal action due to the possible inhibition of lanosterol-14-alpha-demethylase.
Journal of enzyme inhibition 1998;13(4):291-310.
1998: Francesco Mincione; Luca Menabuoni; Fabrizio Briganti; G Mincione; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents.
Journal of enzyme inhibition 1998;13(4):267-84.
1998: Claudiu T Supuran; Andrea Scozzafava; I Saramet; Mircea D Banciu
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with heterocyclic mercaptans, sulfenamides, sulfonamides and their metal complexes.
Journal of enzyme inhibition 1998;13(3):177-94.
1998: Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 1998;13(2):103-23.
1998: Andrea Scozzafava; A Nicolae; O Maior; Fabrizio Briganti; Claudiu T Supuran
The antifungal activity of 2,2'-diamino-4,4'-dithiazole derivatives is due to the possible inhibition of lanosterol-14-alpha-demethylase.
Journal of enzyme inhibition 1998;14(1):49-68.
1997: Fabrizio Briganti; Enrica Pessione; Carlo Giunta; Andrea Scozzafava
Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens.
FEBS letters 1997;416(1):61-4.
1997: Fabrizio Briganti; Stefano Mangani; Pierluigi Orioli; Andrea Scozzafava; G Vernaglione; Claudiu T Supuran
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.
Biochemistry 1997;36(34):10384-92.
1997: Claudiu T Supuran; Fabrizio Briganti; Andrea Scozzafava
Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV.
Journal of enzyme inhibition 1997;12(3):175-90.
1997: Vasili M Travkin; AP Jadan; Fabrizio Briganti; Andrea Scozzafava; Ludmila A Golovleva
Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T.
FEBS letters 1997;407(1):69-72.
1997: Claudiu T Supuran; Andrea Scozzafava
Novel aromatic/heterocyclic sulfonamides and their metal complexes as inhibitors of carbonic anhydrase isozymes I, II and IV.
Journal of enzyme inhibition 1997;12(1):37-51.
1996: J Borràs; J Casanova; T Cristea; A Gheorghe; Andrea Scozzafava; Claudiu T Supuran; V Tudor
Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase.
Metal-based drugs 1996;3(3):143-8.
1994: Ivano Bertini; Fabrizio Briganti; Stefano Mangani; H F Nolting; Andrea Scozzafava
X-ray absorption studies on catechol 2,3-dioxygenase from Pseudomonas putida mt2.
Biochemistry 1994;33(35):10777-84.
1994: Ivano Bertini; Fabrizio Briganti; Stefano Mangani; H F Nolting; Andrea Scozzafava
Substrate, substrate analogue, and inhibitor interactions with the ferrous active site of catechol 2,3-dioxygenase monitored through XAS studies.
FEBS letters 1994;350(2-3):207-12.
1994: Ivano Bertini; Fabrizio Briganti; Andrea Scozzafava
Aliphatic and aromatic inhibitors binding to the active site of catechol 2,3-dioxygenase from Pseudomonas putida mt-2.
FEBS letters 1994;343(1):56-60.
1994: Stefano Mangani; Pierluigi Orioli; Andrea Scozzafava; Luigi Messori; P Carloni
EXAFS studies of Fe(III)-phosvitin at high metal to protein ratios.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1994;7(2):104-8.
1993: Ivano Bertini; Fabrizio Briganti; L Calzolai; Luigi Messori; Andrea Scozzafava
Selective interaction of ferricyanide with cluster I of Clostridium pasteurianum 2[Fe4S4] ferredoxin.
FEBS letters 1993;332(3):268-72.
1993: Andrea Scozzafava; Maria Silvia Viezzoli
The role of the active site amino acid residues on the catalytic activity of Cu2Zn2SOD.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1993;19(1-2):193-204.
1992: Ivano Bertini; Fabrizio Briganti; Claudio Luchinat; Luigi Messori; R Monnanni; Andrea Scozzafava; G Vallini
1H-NMR studies on partially and fully reduced 2(4Fe-4S) ferredoxin from Clostridium pasteurianum.
European journal of biochemistry / FEBS 1992;204(2):831-9.
1991: Ivano Bertini; Fabrizio Briganti; Claudio Luchinat; Luigi Messori; R Monnanni; Andrea Scozzafava; G Vallini
2D 1H NMR studies of oxidized 2(Fe4S4) ferredoxin from Clostridium pasteurianum.
FEBS letters 1991;289(2):253-6.
1990: Wojciech Bal; Ivano Bertini; Henryk Kozlowski; R Monnanni; Andrea Scozzafava; G Z Siatecki
The unusual behavior of the inhibitor S(+)(1-amino-2-phenylethyl)phosphonic acid towards carboxypeptidase A.
Journal of inorganic biochemistry 1990;40(3):227-35.
1990: Ivano Bertini; Fabrizio Briganti; R Monnanni; Andrea Scozzafava; P Carlozzi; R Materassi
1H NMR studies of Chromatium vinosum cytochrome c'.
Archives of biochemistry and biophysics 1990;282(1):84-90.
1989: Lucia Banci; Ivano Bertini; Claudio Luchinat; Andrea Scozzafava
Cyanide and azide behave in a similar fashion versus cuprozinc-superoxide dismutase.
The Journal of biological chemistry 1989;264(17):9742-4.
1986: Ivano Bertini; Claudio Luchinat; Luigi Messori; R Monnanni; Andrea Scozzafava
The metal-binding properties of ovotransferrin. An investigation of cobalt(II) derivatives.
The Journal of biological chemistry 1986;261(3):1139-46.
1984: Ivano Bertini; Claudio Luchinat; Luigi Messori; Andrea Scozzafava
Cobalt(II) as an NMR probe for the investigation of the coordination sites of conalbumin.
European journal of biochemistry / FEBS 1984;141(2):375-8.
1982: Ivano Bertini; Claudio Luchinat; R Monnanni; Andrea Scozzafava
Different behavior of sulfonamides with respect to copper-substituted bovine and human carbonic anhydrases.
Journal of inorganic biochemistry 1982;16(2):155-60.