Andrea Scozzafava

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Carta Fabrizio; Maresca Alfonso; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.
Innocenti Alessio; Pastorekova Silvia; Pastorek Jaromir; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Alterio Vincenzo; Hilvo Mika; Di Fiore Anna; Supuran Claudiu T; Pan Peiwen; Parkkila Seppo; Scaloni Andrea; Pastorek Jaromir; Pastorekova Silvia; Pedone Carlo; Scozzafava Andrea; Monti Simona Maria; De Simone Giuseppina
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Andrea Scozzafava (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Carta Fabrizio; Maresca Alfonso; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.
Bioorganic & medicinal chemistry 2009;17(20):7093-9.
2009: Innocenti Alessio; Pastorekova Silvia; Pastorek Jaromir; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Bioorganic & medicinal chemistry letters 2009;19(20):5825-8.
2009: Alterio Vincenzo; Hilvo Mika; Di Fiore Anna; Supuran Claudiu T; Pan Peiwen; Parkkila Seppo; Scaloni Andrea; Pastorek Jaromir; Pastorekova Silvia; Pedone Carlo; Scozzafava Andrea; Monti Simona Maria; De Simone Giuseppina
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16233-8.
2009: De Simone Giuseppina; Scozzafava Andrea; Supuran Claudiu T
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?
Chemical biology & drug design 2009;74(3):317-21.
2009: Maresca Alfonso; Carta Fabrizio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.
Bioorganic & medicinal chemistry letters 2009;19(17):4929-32.
2009: Dubois Ludwig; Lieuwes Natasja G; Maresca Alfonso; Thiry Anne; Supuran Claudiu T; Scozzafava Andrea; Wouters Bradly G; Lambin Philippe
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2009;92(3):423-8.
2009: Parkkila Seppo; Innocenti Alessio; Kallio Heini; Hilvo Mika; Scozzafava Andrea; Supuran Claudiu T
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry letters 2009;19(15):4102-6.
2009: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Inhibition of carbonic anhydrase IX: a new strategy against cancer.
Anti-cancer agents in medicinal chemistry 2009;9(6):693-702.
2009: Güzel Ozlen; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Supuran Claudiu T
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Bioorganic & medicinal chemistry 2009;17(14):4894-9.
2009: Bertucci Anthony; Innocenti Alessio; Zoccola Didier; Scozzafava Andrea; Tambutté Sylvie; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
Bioorganic & medicinal chemistry 2009;17(14):5054-8.
2009: Innocenti Alessio; Hilvo Mika; Parkkila Seppo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2009;19(13):3430-3.
2009: Innocenti Alessio; Hall Rebecca A; Schlicker Christine; Scozzafava Andrea; Steegborn Clemens; Mühlschlegel Fritz A; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
Bioorganic & medicinal chemistry 2009;17(13):4503-9.
2009: Güzel Ozlen; Maresca Alfonso; Scozzafava Andrea; Salman Aydin; Balaban Alexandru T; Supuran Claudiu T
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Journal of medicinal chemistry 2009;52(13):4063-7.
2009: Güzel Ozlen; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Supuran Claudiu T
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(12):3170-3.
2009: Güzel Ozlen; Maresca Alfonso; Scozzafava Andrea; Salman Aydin; Balaban Alexandru T; Supuran Claudiu T
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.
Bioorganic & medicinal chemistry letters 2009;19(11):2931-4.
2009: Winum Jean-Yves; Innocenti Alessio; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.
Bioorganic & medicinal chemistry 2009;17(10):3649-52.
2009: Innocenti Alessio; Winum Jean-Yves; Hall Rebecca A; Mühlschlegel Fritz A; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Bioorganic & medicinal chemistry letters 2009;19(10):2642-5.
2009: Abdo Marie-Rose; Vullo Daniela; Saada Mohamed-Chiheb; Montero Jean-Louis; Scozzafava Andrea; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.
Bioorganic & medicinal chemistry letters 2009;19(9):2440-3.
2009: Nishimori Isao; Minakuchi Tomoko; Vullo Daniela; Scozzafava Andrea; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
Journal of medicinal chemistry 2009;52(9):3116-20.
2009: Ebbesen Peter; Pettersen Erik O; Gorr Thomas A; Jobst Gerhard; Williams Kaye; Kieninger Jochen; Wenger Roland H; Pastorekova Silvia; Dubois Ludwig; Lambin Philippe; Wouters Brad G; Van Den Beucken Twan; Supuran Claudiu T; Poellinger Lorenz; Ratcliffe Peter; Kanopka Arvydas; Görlach Agnes; Gasmann Max; Harris Adrian L; Maxwell Patrick; Scozzafava Andrea
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.
Journal of enzyme inhibition and medicinal chemistry 2009;24 Suppl 1():1-39.
2009: Minakuchi Tomoko; Nishimori Isao; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
Journal of medicinal chemistry 2009;52(8):2226-32.
2009: Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(7):1855-7.
2009: Güzel Ozlen; Innocenti Alessio; Hall Rebecca A; Scozzafava Andrea; Mühlschlegel Fritz A; Supuran Claudiu T
Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2009;17(8):3212-5.
2009: Singh Shalini; Khadikar Padmakar V; Scozzafava Andrea; Supuran Claudiu T
QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):337-49.
2009: Morsy Salwa M I; Badawi Abdelfattah M; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):499-505.
2009: Isik Semra; Kockar Feray; Aydin Meltem; Arslan Oktay; Guler Ozen Ozensoy; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
Bioorganic & medicinal chemistry letters 2009;19(6):1662-5.
2009: Crocetti Letizia; Maresca Alfonso; Temperini Claudia; Hall Rebecca A; Scozzafava Andrea; Mühlschlegel Fritz A; Supuran Claudiu T
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Bioorganic & medicinal chemistry letters 2009;19(5):1371-5.
2009: Hilvo Mika; Salzano Anna Maria; Innocenti Alessio; Kulomaa Markku S; Scozzafava Andrea; Scaloni Andrea; Parkkila Seppo; Supuran Claudiu T
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Journal of medicinal chemistry 2009;52(3):646-54.
2009: Innocenti Alessio; Hilvo Mika; Parkkila Seppo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(4):1155-8.
2009: Isik Semra; Kockar Feray; Aydin Meltem; Arslan Oktay; Guler Ozen Ozensoy; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
Bioorganic & medicinal chemistry 2009;17(3):1158-63.
2009: Bertucci Anthony; Innocenti Alessio; Zoccola Didier; Scozzafava Andrea; Allemand Denis; Tambutté Sylvie; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(3):650-3.
2009: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Bioorganic & medicinal chemistry 2009;17(3):1214-21.
2009: Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Vullo Daniela; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):70-6.
2009: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.
Journal of medicinal chemistry 2009;52(2):322-8.
2009: Kolomytseva Marina P; Randazzo Dimetrio; Baskunov Boris P; Scozzafava Andrea; Briganti Fabrizio; Golovleva Ludmila A
Role of surfactants in optimizing fluorene assimilation and intermediate formation by Rhodococcus rhodochrous VKM B-2469.
Bioresource technology 2009;100(2):839-44.
2008: Chernykh A; Myasoedova N; Kolomytseva M; Ferraroni M; Briganti F; Scozzafava A; Golovleva L
Laccase isoforms with unusual properties from the basidiomycete Steccherinum ochraceum strain 1833.
Journal of applied microbiology 2008;105(6):2065-75.
2008: Smaine Fatma-Zohra; Pacchiano Fabio; Rami Marouan; Barragan-Montero Véronique; Vullo Daniela; Scozzafava Andrea; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Bioorganic & medicinal chemistry letters 2008;18(24):6332-5.
2008: Stiti Maamar; Cecchi Alessandro; Rami Marouan; Abdaoui Mohamed; Barragan-Montero Véronique; Scozzafava Andrea; Guari Yannick; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.
Journal of the American Chemical Society 2008;130(48):16130-1.
2008: Innocenti Alessio; Zimmerman Sabrina A; Scozzafava Andrea; Ferry James G; Supuran Claudiu T
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
Bioorganic & medicinal chemistry letters 2008;18(23):6194-8.
2008: Thiry Anne; Rolin Stéphanie; Vullo Daniela; Frankart Aurélie; Scozzafava Andrea; Dogné Jean-Michel; Wouters Johan; Supuran Claudiu T; Masereel Bernard
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
European journal of medicinal chemistry 2008;43(12):2853-60.
2008: Rami Marouan; Cecchi Alessandro; Montero Jean-Louis; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.
ChemMedChem 2008;3(11):1780-8.
2008: Gullotto Antonella; Branciamore Sergio; Duchi Ilaria; Caño Maria Francisca Pareja; Randazzo Demetrio; Tilli Silvia; Giardina Paola; Sannia Giovanni; Scozzafava Andrea; Briganti Fabrizio
Combined action of a bacterial monooxygenase and a fungal laccase for the biodegradation of mono- and poly-aromatic hydrocarbons.
Bioresource technology 2008;99(17):8353-9.
2008: Güzel Ozlen; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Parkkila Seppo; Hilvo Mika; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2008;16(20):9113-20.
2008: Hilvo Mika; Baranauskiene Lina; Salzano Anna Maria; Scaloni Andrea; Matulis Daumantas; Innocenti Alessio; Scozzafava Andrea; Monti Simona Maria; Di Fiore Anna; De Simone Giuseppina; Lindfors Mikaela; Jänis Janne; Valjakka Jarkko; Pastoreková Silvia; Pastorek Jaromir; Kulomaa Markku S; Nordlund Henri R; Supuran Claudiu T; Parkkila Seppo
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
The Journal of biological chemistry 2008;283(41):27799-809.
2008: Hall Rebecca A; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T; Klappa Peter; Mühlschlegel Fritz A
External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans.
Molecular and biochemical parasitology 2008;161(2):140-9.
2008: Ciullini Ilaria; Tilli Silvia; Scozzafava Andrea; Briganti Fabrizio
Fungal laccase, cellobiose dehydrogenase, and chemical mediators: combined actions for the decolorization of different classes of textile dyes.
Bioresource technology 2008;99(15):7003-10.
2008: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
Bioorganic & medicinal chemistry 2008;16(18):8373-8.
2008: Innocenti Alessio; Mühlschlegel Fritz A; Hall Rebecca A; Steegborn Clemens; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
Bioorganic & medicinal chemistry letters 2008;18(18):5066-70.
2008: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(15):4282-6.
2008: Vullo Daniela; Nishimori Isao; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2008;18(15):4303-7.
2008: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Bioorganic & medicinal chemistry 2008;16(15):7424-8.
2008: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?
Organic & biomolecular chemistry 2008;6(14):2499-506.
2008: Innocenti Alessio; Maresca Alfonso; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
Bioorganic & medicinal chemistry letters 2008;18(14):3938-41.
2008: Matera Irene; Ferraroni Marta; Bürger Sibylle; Scozzafava Andrea; Stolz Andreas; Briganti Fabrizio
Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase.
Journal of molecular biology 2008;380(5):856-68.
2008: Cecchi Alessandro; Ciani Laura; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Ristori Sandra; Supuran Claudiu T
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.
Bioorganic & medicinal chemistry letters 2008;18(12):3475-80.
2008: Innocenti Alessio; Hilvo Mika; Scozzafava Andrea; Parkkila Seppo; Supuran Claudiu T
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Bioorganic & medicinal chemistry letters 2008;18(12):3593-6.
2008: D'Ambrosio Katia; Vitale Rosa-Maria; Dogné Jean-Michel; Masereel Bernard; Innocenti Alessio; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.
Journal of medicinal chemistry 2008;51(11):3230-7.
2008: Winum Jean-Yves; Rami Marouan; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.
Medicinal research reviews 2008;28(3):445-63.
2008: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Bioorganic & medicinal chemistry letters 2008;18(8):2567-73.
2008: Di Fiore Anna; Pedone Carlo; Antel Jochen; Waldeck Harald; Witte Andreas; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T; De Simone Giuseppina
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(8):2669-74.
2008: Innocenti Alessio; Scozzafava Andrea; Parkkila Seppo; Puccetti Luca; De Simone Giuseppina; Supuran Claudiu T
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.
Bioorganic & medicinal chemistry letters 2008;18(7):2267-71.
2008: Pastorekova Silvia; Vullo Daniela; Nishimori Isao; Scozzafava Andrea; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
Bioorganic & medicinal chemistry 2008;16(7):3530-6.
2008: Saczewski Franciszek; Innocenti Alessio; Slawinski Jaroslaw; Kornicka Anita; Brzozowski Zdzislaw; Pomarnacka Elzbieta; Scozzafava Andrea; Temperini Claudia; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Bioorganic & medicinal chemistry 2008;16(7):3933-40.
2008: Innocenti Alessio; Hilvo Mika; Scozzafava Andrea; Lindfors Mikaela; Nordlund Henri R; Kulomaa Markku S; Parkkila Seppo; Supuran Claudiu T
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
Bioorganic & medicinal chemistry letters 2008;18(6):1898-903.
2008: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).
Bioorganic & medicinal chemistry letters 2008;18(5):1583-7.
2008: D'Ambrosio Katia; Masereel Bernard; Thiry Anne; Scozzafava Andrea; Supuran Claudiu T; De Simone Giuseppina
Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.
ChemMedChem 2008;3(3):473-7.
2008: Almajan Gabriela Laura; Barbuceanu Stefania-Felicia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols.
Journal of enzyme inhibition and medicinal chemistry 2008;23(1):101-7.
2008: Temperini Claudia; Cecchi Alessandro; Boyle Nicholas A; Scozzafava Andrea; Cabeza Jaime Escribano; Wentworth Paul; Blackburn G Michael; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(3):999-1005.
2008: Rami Marouan; Winum Jean-Yves; Innocenti Alessio; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Bioorganic & medicinal chemistry letters 2008;18(2):836-41.
2008: Güzel Ozlen; Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(1):152-8.
2008: Morishita Saori; Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Takeuchi Hiroaki; Sugiura Tetsuro; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori.
Journal of gastroenterology 2008;43(11):849-57.
2008: Temperini Claudia; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activation and the drug design.
Current pharmaceutical design 2008;14(7):708-15.
2008: Mincione Francesco; Scozzafava Andrea; Supuran Claudiu T
The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents.
Current pharmaceutical design 2008;14(7):649-54.
2008: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Design of zinc binding functions for carbonic anhydrase inhibitors.
Current pharmaceutical design 2008;14(7):615-21.
2007: Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Vullo Daniela; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Bioorganic & medicinal chemistry 2007;15(23):7229-36.
2007: Nishimori Isao; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.
Bioorganic & medicinal chemistry 2007;15(21):6742-7.
2007: Colinas Pedro A; Bravo Rodolfo D; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(18):5086-90.
2007: Smaine Fatma-Zohra; Winum Jean-Yves; Montero Jean-Louis; Regainia Zine; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.
Bioorganic & medicinal chemistry letters 2007;17(18):5096-100.
2007: Temperini Claudia; Innocenti Alessio; Mastrolorenzo Antonio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(17):4866-72.
2007: Alterio Vincenzo; De Simone Giuseppina; Monti Simona Maria; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(15):4201-7.
2007: Vullo Daniela; Innocenti Alessio; Nishimori Isao; Scozzafava Andrea; Kaila Kai; Supuran Claudiu T
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
Bioorganic & medicinal chemistry letters 2007;17(15):4107-12.
2007: Nishimori Isao; Onishi Saburo; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
Bioorganic & medicinal chemistry 2007;15(15):5351-7.
2007: Nishimori Isao; Minakuchi Tomoko; Kohsaki Takuhiro; Onishi Saburo; Takeuchi Hiroaki; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(13):3585-94.
2007: Supuran Claudiu T; Scozzafava Andrea
Carbonic anhydrases as targets for medicinal chemistry.
Bioorganic & medicinal chemistry 2007;15(13):4336-50.
2007: Dubois Ludwig; Douma Kim; Supuran Claudiu T; Chiu Roland K; van Zandvoort Marc A M J; Pastoreková Silvia; Scozzafava Andrea; Wouters Bradly G; Lambin Philippe
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;83(3):367-73.
2007: Vitale Rosa Maria; Pedone Carlo; Amodeo Pietro; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T; De Simone Giuseppina
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.
Bioorganic & medicinal chemistry 2007;15(12):4152-8.
2007: Winum Jean-Yves; Thiry Anne; Cheikh Khaled El; Dogné Jean-Michel; Montero Jean-Louis; Vullo Daniela; Scozzafava Andrea; Masereel Bernard; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.
Bioorganic & medicinal chemistry letters 2007;17(10):2685-91.
2007: Temperini Claudia; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2795-801.
2007: Temperini Claudia; Innocenti Alessio; Guerri Annalisa; Scozzafava Andrea; Rusconi Stefano; Supuran Claudiu T
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Bioorganic & medicinal chemistry letters 2007;17(8):2210-5.
2007: Nuti Elisa; Orlandini Elisabetta; Nencetti Susanna; Rossello Armando; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Bioorganic & medicinal chemistry 2007;15(6):2298-311.
2007: Innocenti Alessio; Vullo Daniela; Pastorek Jaromir; Scozzafava Andrea; Pastorekova Silvia; Nishimori Isao; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
Bioorganic & medicinal chemistry letters 2007;17(6):1532-7.
2007: Santos M Amelia; Marques Sergio; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1538-43.
2007: Di Fiore Anna; Scozzafava Andrea; Winum Jean-Yves; Montero Jean-Louis; Pedone Carlo; Supuran Claudiu T; De Simone Giuseppina
Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1726-31.
2007: Vullo Daniela; Nishimori Isao; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
Bioorganic & medicinal chemistry letters 2007;17(5):1336-40.
2007: Nishimori Isao; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.
Bioorganic & medicinal chemistry letters 2007;17(4):1037-42.
2007: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
Bioorganic & medicinal chemistry letters 2007;17(3):628-35.
2007: Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
Journal of medicinal chemistry 2007;50(2):381-8.
2007: Casini Angela; Mastrobuoni Guido; Temperini Claudia; Gabbiani Chiara; Francese Simona; Moneti Gloriano; Supuran Claudiu T; Scozzafava Andrea; Messori Luigi
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme.
Chemical communications (Cambridge, England) 2007;(2):156-8.
2007: Mastrolorenzo Antonio; Rusconi Stefano; Scozzafava Andrea; Barbaro Giuseppe; Supuran Claudiu T
Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors.
Current medicinal chemistry 2007;14(26):2734-48.
2007: Ferraroni Marta; Myasoedova Nina M; Schmatchenko Vadim; Leontievsky Alexey A; Golovleva Ludmila A; Scozzafava Andrea; Briganti Fabrizio
Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases.
BMC structural biology 2007;7():60.
2007: Rusconi Stefano; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
An update in the development of HIV entry inhibitors.
Current topics in medicinal chemistry 2007;7(13):1273-89.
2007: Mincione Francesco; Scozzafava Andrea; Supuran Claudiu T
The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents.
Current topics in medicinal chemistry 2007;7(9):849-54.
2007: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Metal binding functions in the design of carbonic anhydrase inhibitors.
Current topics in medicinal chemistry 2007;7(9):835-48.
2006: Menchise Valeria; De Simone Giuseppina; Di Fiore Anna; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.
Bioorganic & medicinal chemistry letters 2006;16(24):6204-8.
2006: Winum Jean-Yves; Temperini Claudia; El Cheikh Khaled; Innocenti Alessio; Vullo Daniela; Ciattini Samuele; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
Journal of medicinal chemistry 2006;49(24):7024-31.
2006: Weber Alexander; Böhm Markus; Supuran Claudiu T; Scozzafava Andrea; Sotriffer Christoph A; Klebe Gerhard
3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors.
Journal of chemical information and modeling 2006;46(6):2737-60.
2006: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Therapeutic potential of sulfamides as enzyme inhibitors.
Medicinal research reviews 2006;26(6):767-92.
2006: Saczewski Franciszek; Innocenti Alessio; Brzozowski Zdzislaw; Slawinski Jaroslaw; Pomarnacka Elzbieta; Kornicka Anita; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2006;21(5):563-8.
2006: Temperini Claudia; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.
Bioorganic & medicinal chemistry letters 2006;16(19):5152-6.
2006: De Simone Giuseppina; Vitale Rosa Maria; Di Fiore Anna; Pedone Carlo; Scozzafava Andrea; Montero Jean-Louis; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
Journal of medicinal chemistry 2006;49(18):5544-51.
2006: Saczewski Franciszek; Slawinski Jaroslaw; Kornicka Anita; Brzozowski Zdzislaw; Pomarnacka Elzbieta; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.
Bioorganic & medicinal chemistry letters 2006;16(18):4846-51.
2006: Temperini Claudia; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(27):7057-66.
2006: Winum Jean-Yves; Cecchi Alessandro; Seridi Achour; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides--a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):477-81.
2006: Zareef Muhammad; Innocenti Alessio; Iqbal Rashid; Zaidi Javid H; Arfan Muhammad; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):351-9.
2006: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.
Mini reviews in medicinal chemistry 2006;6(8):921-36.
2006: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4316-20.
2006: Parkkila Seppo; Vullo Daniela; Puccetti Luca; Parkkila Anna-Kaisa; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
Bioorganic & medicinal chemistry letters 2006;16(15):3955-9.
2006: Ferraroni Marta; Kolomytseva Marina P; Solyanikova Inna P; Scozzafava Andrea; Golovleva Ludmila A; Briganti Fabrizio
Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.
Journal of molecular biology 2006;360(4):788-99.
2006: Alterio Vincenzo; Vitale Rosa Maria; Monti Simona Maria; Pedone Carlo; Scozzafava Andrea; Cecchi Alessandro; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
Journal of the American Chemical Society 2006;128(25):8329-35.
2006: Vullo Daniela; Ruusuvuori Eva; Kaila Kai; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Bioorganic & medicinal chemistry letters 2006;16(12):3139-43.
2006: Temperini Claudia; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
Journal of medicinal chemistry 2006;49(10):3019-27.
2006: Nishimori Isao; Vullo Daniela; Minakuchi Tomoko; Morimoto Kaori; Onishi Saburo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
Bioorganic & medicinal chemistry letters 2006;16(8):2182-8.
2006: Vullo Daniela; Steffansen Bente; Brodin Birger; Supuran Claudiu T; Scozzafava Andrea; Nielsen Carsten Uhd
Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.
Bioorganic & medicinal chemistry 2006;14(7):2418-27.
2006: Nishimori Isao; Minakuchi Tomoko; Morimoto Kaori; Sano Shuichi; Onishi Saburo; Takeuchi Hiroaki; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
Journal of medicinal chemistry 2006;49(6):2117-26.
2006: Di Fiore Anna; Pedone Carlo; D'Ambrosio Katia; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.
Bioorganic & medicinal chemistry letters 2006;16(2):437-42.
2006: Supuran Claudiu T; Mastrolorenzo Antonio; Barbaro Giuseppe; Scozzafava Andrea
Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles.
Current pharmaceutical design 2006;12(27):3459-65.
2005: Nishimori Isao; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
Journal of medicinal chemistry 2005;48(24):7860-6.
2005: Temperini Claudia; Scozzafava Andrea; Puccetti Luca; Supuran Claudiu T
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.
Bioorganic & medicinal chemistry letters 2005;15(23):5136-41.
2005: Cecchi Alessandro; Taylor Scott D; Liu Yong; Hill Bryan; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(23):5192-6.
2005: Ozensoy Ozen; Puccetti Luca; Fasolis Giuseppe; Arslan Oktay; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(21):4862-6.
2005: Innocenti Alessio; Villar Raquel; Martinez-Merino Victor; Gil María J; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(21):4872-6.
2005: Ozensoy Ozen; Nishimori Isao; Vullo Daniela; Puccetti Luca; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides.
Bioorganic & medicinal chemistry 2005;13(22):6089-93.
2005: Menchise Valeria; De Simone Giuseppina; Alterio Vincenzo; Di Fiore Anna; Pedone Carlo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.
Journal of medicinal chemistry 2005;48(18):5721-7.
2005: Mincione Francesco; Starnotti Michele; Masini Emanuela; Bacciottini Lucia; Scrivanti Chiara; Casini Angela; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Bioorganic & medicinal chemistry letters 2005;15(17):3821-7.
2005: Nishimori Isao; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(17):3828-33.
2005: Ozensoy Ozen; Isik Semra; Arslan Oktay; Arslan Mikail; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(4):383-7.
2005: Cecchi Alessandro; Hulikova Alzbeta; Pastorek Jaromír; Pastoreková Silvia; Scozzafava Andrea; Winum Jean-Yves; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Journal of medicinal chemistry 2005;48(15):4834-41.
2005: Winum Jean-Yves; Cecchi Alessandro; Montero Jean-Louis; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.
Bioorganic & medicinal chemistry letters 2005;15(13):3302-6.
2005: Chohan Zahid H; Supuran Claudiu T; Scozzafava Andrea
Metal binding and antibacterial activity of ciprofloxacin complexes.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):303-7.
2005: Pastorekova Silvia; Vullo Daniela; Casini Angela; Scozzafava Andrea; Pastorek Jaromir; Nishimori Isao; Supuran Claudiu T
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):211-7.
2005: Puccetti Luca; Fasolis Giuseppe; Vullo Daniela; Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.
Bioorganic & medicinal chemistry letters 2005;15(12):3096-101.
2005: Garaj Vladimir; Puccetti Luca; Fasolis Giuseppe; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Bioorganic & medicinal chemistry letters 2005;15(12):3102-8.
2005: Ferraroni Marta; Seifert Jana; Travkin Vasili M; Thiel Monika; Kaschabek Stefan; Scozzafava Andrea; Golovleva Ludmila; Schlömann Michael; Briganti Fabrizio
Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation.
The Journal of biological chemistry 2005;280(22):21144-54.
2005: Puccetti Luca; Fasolis Giuseppe; Cecchi Alessandro; Winum Jean-Yves; Gamberi Alessandro; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Bioorganic & medicinal chemistry letters 2005;15(9):2359-64.
2005: Winum Jean-Yves; Innocenti Alessio; Nasr Jihane; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(9):2353-8.
2005: Almajan Gabriela Laura; Innocenti Alessio; Puccetti Luca; Manole Gheorghe; Barbuceanu Stefania; Saramet Ioana; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.
Bioorganic & medicinal chemistry letters 2005;15(9):2347-52.
2005: De Simone Giuseppina; Di Fiore Anna; Menchise Valeria; Pedone Carlo; Antel Jochen; Casini Angela; Scozzafava Andrea; Wurl Michael; Supuran Claudiu T
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2005;15(9):2315-20.
2005: Di Fiore Anna; De Simone Giuseppina; Menchise Valeria; Pedone Carlo; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.
Bioorganic & medicinal chemistry letters 2005;15(7):1937-42.
2005: Innocenti Alessio; Antel Jochen; Wurl Michael; Vullo Daniela; Firnges Michael A; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
Bioorganic & medicinal chemistry letters 2005;15(7):1909-13.
2005: Winum Jean-Yves; Dogné Jean-Michel; Casini Angela; de Leval Xavier; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Journal of medicinal chemistry 2005;48(6):2121-5.
2005: Winum Jean-Yves; Innocenti Alessio; Gagnard Valerie; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.
Bioorganic & medicinal chemistry letters 2005;15(6):1683-6.
2005: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Sulfamates and their therapeutic potential.
Medicinal research reviews 2005;25(2):186-228.
2005: Ferraroni Marta; Duchi Ilaria; Myasoedova Nina M; Leontievsky Alexey A; Golovleva Ludmila A; Scozzafava Andrea; Briganti Fabrizio
Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):205-7.
2005: Innocenti Alessio; Firnges Michael A; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(4):1149-54.
2005: Vullo Daniela; Voipio Juha; Innocenti Alessio; Rivera Claudio; Ranki Harri; Scozzafava Andrea; Kaila Kai; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(4):971-6.
2005: Vullo Daniela; Innocenti Alessio; Nishimori Isao; Pastorek Jaromír; Scozzafava Andrea; Pastoreková Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Bioorganic & medicinal chemistry letters 2005;15(4):963-9.
2005: Winum Jean-Yves; Pastorekova Silvia; Jakubickova Lydia; Montero Jean-Louis; Scozzafava Andrea; Pastorek Jaromir; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Bioorganic & medicinal chemistry letters 2005;15(3):579-84.
2005: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Casey Joseph R; Supuran Claudiut
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.
Bioorganic & medicinal chemistry letters 2005;15(3):573-8.
2005: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
Bioorganic & medicinal chemistry letters 2005;15(3):567-71.
2005: Turkmen Hasan; Durgun Mustafa; Yilmaztekin Serpil; Emul Mahmut; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2005;15(2):367-72.
2005: Krungkrai Jerapan; Scozzafava Andrea; Reungprapavut Sutarnthip; Krungkrai Sudaratana R; Rattanajak Roonglawan; Kamchonwongpaisan Sumalee; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?
Bioorganic & medicinal chemistry 2005;13(2):483-9.
2005: Barbaro Giuseppe; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome.
Current pharmaceutical design 2005;11(14):1805-43.
2004: Rusconi Stefano; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
New advances in HIV entry inhibitors development.
Current drug targets. Infectious disorders 2004;4(4):339-55.
2004: Zimmerman Sabrina; Innocenti Alessio; Casini Angela; Ferry James G; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(24):6001-6.
2004: Chazalette Celine; Masereel Bernard; Rolin Stéphanie; Thiry Anne; Scozzafava Andrea; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.
Bioorganic & medicinal chemistry letters 2004;14(23):5781-6.
2004: Cecchi Alessandro; Winum Jean-Yves; Innocenti Alessio; Vullo Daniela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.
Bioorganic & medicinal chemistry letters 2004;14(23):5775-80.
2004: Innocenti Alessio; Firnges Michael A; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
Bioorganic & medicinal chemistry letters 2004;14(23):5769-73.
2004: Rusconi Stefano; Innocenti Alessio; Vullo Daniela; Mastrolorenzo Antonio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.
Bioorganic & medicinal chemistry letters 2004;14(23):5763-7.
2004: Svastová Eliska; Hulíková Alzbeta; Rafajová Monika; Zat'ovicová Miriam; Gibadulinová Adriana; Casini Angela; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T; Pastorek Jaromír; Pastoreková Silvia
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
FEBS letters 2004;577(3):439-45.
2004: Innocenti Alessio; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Bioorganic & medicinal chemistry letters 2004;14(22):5703-7.
2004: Innocenti Alessio; Lehtonen Jonna M; Parkkila Seppo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
Bioorganic & medicinal chemistry letters 2004;14(21):5435-9.
2004: Garaj Vladimir; Puccetti Luca; Fasolis Giuseppe; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.
Bioorganic & medicinal chemistry letters 2004;14(21):5427-33.
2004: Innocenti Alessio; Casini Angela; Alcaro Maria C; Papini Anna M; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.
Journal of medicinal chemistry 2004;47(21):5224-9.
2004: Innocenti Alessio; Zimmerman Sabrina; Ferry James G; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
Bioorganic & medicinal chemistry letters 2004;14(17):4563-7.
2004: Supuran Claudiu T; Casini Angela; Mastrolorenzo Antonio; Scozzafava Andrea
COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.
Mini reviews in medicinal chemistry 2004;4(6):625-32.
2004: Lehtonen Jonna M; Parkkila Seppo; Vullo Daniela; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Bioorganic & medicinal chemistry letters 2004;14(14):3757-62.
2004: Tripodi Sergio A; Del Vecchio Maria Teresa; Supuran Claudiu T; Scozzafava Andrea; Gabrielli M Gabriella; Pastorekova Silvia; Rossie Ranieri; Fasolis Giuseppe; Puccetti Luca
Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):287-91.
2004: Bonnac Laurent; Innocenti Alessio; Winum Jean-Yves; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Barragan Veronique; Supuran Claudiu T
Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):275-8.
2004: Supuran Claudiu T; Scozzafava Andrea
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):269-73.
2004: Mahmood-Ul-Hassan; Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):263-7.
2004: Innocenti Alessio; Zimmerman Sabrina; Ferry James G; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt gamma-class enzyme from the archaeon Methanosarcina thermophila with anions.
Bioorganic & medicinal chemistry letters 2004;14(12):3327-31.
2004: Jaiswal Mona; Khadikar Padmakar V; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(12):3283-90.
2004: Ferraroni Marta; Solyanikova Inna P; Kolomytseva Marina P; Scozzafava Andrea; Golovleva Ludmila; Briganti Fabrizio
Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP.
The Journal of biological chemistry 2004;279(26):27646-55.
2004: de Leval Xavier; Ilies Monica; Casini Angela; Dogné Jean-Michel; Scozzafava Andrea; Masini Emanuela; Mincione Francesco; Starnotti Michele; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Journal of medicinal chemistry 2004;47(11):2796-804.
2004: Ilies Marc A; Masereel Bernard; Rolin Stéphanie; Scozzafava Andrea; Câmpeanu Gheorghe; Cîmpeanu Valentin; Supuran Claudiu T
Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.
Bioorganic & medicinal chemistry 2004;12(10):2717-26.
2004: Abbate Francesco; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide.
Bioorganic & medicinal chemistry letters 2004;14(9):2357-61.
2004: Vullo Daniela; Scozzafava Andrea; Pastorekova Silvia; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Bioorganic & medicinal chemistry letters 2004;14(9):2351-6.
2004: Casey Joseph R; Morgan Patricio E; Vullo Daniela; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.
Journal of medicinal chemistry 2004;47(9):2337-47.
2004: Chohan Zahid H; Supuran Claudiu T; Scozzafava Andrea
Metalloantibiotics: synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):79-84.
2004: Pastorekova Silvia; Casini Angela; Scozzafava Andrea; Vullo Daniela; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(4):869-73.
2004: Vullo Daniela; Franchi Marco; Gallori Enzo; Antel Jochen; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.
Journal of medicinal chemistry 2004;47(5):1272-9.
2004: Supuran Claudiu T; Innocenti Alessio; Mastrolorenzo Antonio; Scozzafava Andrea
Antiviral sulfonamide derivatives.
Mini reviews in medicinal chemistry 2004;4(2):189-200.
2004: Supuran Claudiu T; Vullo Daniela; Manole Gheorghe; Casini Angela; Scozzafava Andrea
Designing of novel carbonic anhydrase inhibitors and activators.
Current medicinal chemistry. Cardiovascular and hematological agents 2004;2(1):49-68.
2004: Weber Alexander; Casini Angela; Heine Andreas; Kuhn Daniel; Supuran Claudiu T; Scozzafava Andrea; Klebe Gerhard
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
Journal of medicinal chemistry 2004;47(3):550-7.
2004: Abbate Francesco; Coetzee Anita; Casini Angela; Ciattini Samuele; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.
Bioorganic & medicinal chemistry letters 2004;14(2):337-41.
2004: Abbate Francesco; Winum Jean-Yves; Potter Barry V L; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.
Bioorganic & medicinal chemistry letters 2004;14(1):231-4.
2004: Winum Jean-Yves; Casini Angela; Mincione Francesco; Starnotti Michele; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Bioorganic & medicinal chemistry letters 2004;14(1):225-9.
2004: Abbate Francesco; Casini Angela; Owa Takashi; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(1):217-23.
2004: Lehtonen Jonna; Shen Bairong; Vihinen Mauno; Casini Angela; Scozzafava Andrea; Supuran Claudiu T; Parkkila Anna-Kaisa; Saarnio Juha; Kivelä Antti J; Waheed Abdul; Sly William S; Parkkila Seppo
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
The Journal of biological chemistry 2004;279(4):2719-27.
2004: Randazzo Demetrio; Ferraroni Marta; Scozzafava Andrea; Golovleva Ludmila; Briganti Fabrizio
Biotransformation of chloroaromatics: the impact of bioavailability and substrate specificity.
Bioinorganic chemistry and applications 2004;():209-23.
2003: Winum Jean-Yves; Vullo Daniela; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Journal of medicinal chemistry 2003;46(25):5471-7.
2003: Vullo Daniela; Franchi Marco; Gallori Enzo; Pastorek Jaromir; Scozzafava Andrea; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):403-6.
2003: Mastrolorenzo Antonio; Zuccati Giuliano; Massi Daniela; Gabrielli Maria G; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Immunohistochemical study of carbonic anhydrase isozymes in human skin.
European journal of dermatology : EJD 2003;13(5):440-4.
2003: Casini Angela; Scozzafava Andrea; Mincione Francesco; Menabuoni Luca; Starnotti Michele; Supuran Claudiu T
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
Bioorganic & medicinal chemistry letters 2003;13(17):2867-73.
2003: Franchi Marco; Vullo Daniela; Gallori Enzo; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions.
Bioorganic & medicinal chemistry letters 2003;13(17):2857-61.
2003: Supuran Claudiu T; Casini Angela; Scozzafava Andrea
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
Medicinal research reviews 2003;23(5):535-58.
2003: Franchi Marco; Vullo Daniela; Gallori Enzo; Pastorek Jaromir; Russo Antonella; Scozzafava Andrea; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):333-8.
2003: Abbate Francesco; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):303-8.
2003: De Simone Giuseppina; Menchise Valeria; Omaggio Salvatore; Pedone Carlo; Scozzafava Andrea; Supuran Claudiu T
Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
Biochemistry 2003;42(30):9013-21.
2003: Casini Angela; Caccia Silvio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II.
Bioorganic & medicinal chemistry letters 2003;13(16):2765-8.
2003: Casini Angela; Abbate Francesco; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?
Bioorganic & medicinal chemistry letters 2003;13(16):2759-63.
2003: Bencini Alessandro; Bill Eckhard; Scozzafava Andrea; Totti Federico
Density functional characterization of the chemoselective oxidation of catechol by using molecular oxygen: thermodynamics of the reaction between [(triphos)Ir(dtbc)]+ and O2.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(13):3015-23.
2003: Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Zinc complexes of benzothiazole-derived Schiff bases with antibacterial activity.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):259-63.
2003: Santos M Amélia; Marques Sérgio; Gil Marco; Tegoni Matteo; Scozzafava Andrea; Supuran Claudiu T
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):233-42.
2003: Scozzafava Andrea; Owa Takashi; Mastrolorenzo Antonio; Supuran Claudiu T
Anticancer and antiviral sulfonamides.
Current medicinal chemistry 2003;10(11):925-53.
2003: Winum Jean-Yves; Vullo Daniela; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(11):2197-204.
2003: Ilies Marc A; Vullo Daniela; Pastorek Jaromir; Scozzafava Andrea; Ilies Monica; Caproiu Miron T; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Journal of medicinal chemistry 2003;46(11):2187-96.
2003: Scozzafava Andrea; Supuran Claudiu T
Hydroxyurea is a carbonic anhydrase inhibitor.
Bioorganic & medicinal chemistry 2003;11(10):2241-6.
2003: Ilies Monica; Banciu Mircea D; Scozzafava Andrea; Ilies Marc A; Caproiu Miron T; Supuran Claudiu T
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.
Bioorganic & medicinal chemistry 2003;11(10):2227-39.
2003: Vullo Daniela; Franchi Marco; Gallori Enzo; Pastorek Jaromir; Scozzafava Andrea; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2003;13(6):1005-9.
2003: Casini Angela; Antel Jochen; Abbate Francesco; Scozzafava Andrea; David Samuel; Waldeck Harald; Schäfer Siegfried; Supuran Claudiu T
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
Bioorganic & medicinal chemistry letters 2003;13(5):841-5.
2003: Casini Angela; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
Bioorganic & medicinal chemistry letters 2003;13(5):837-40.
2003: Supuran Claudiu T; Scozzafava Andrea; Casini Angela
Carbonic anhydrase inhibitors.
Medicinal research reviews 2003;23(2):146-89.
2003: Ferraroni Marta; Ruiz Tarifa Maria Yolanda; Scozzafava Andrea; Solyanikova Inna P; Kolomytseva Marina P; Golovleva Ludmilla; Briganti Fabrizio
Preliminary crystallographic analysis of 3-chlorocatechol 1,2-dioxygenase of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):188-90.
2002: Casini Angela; Scozzafava Andrea; Mincione Francesco; Menabuoni Luca; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis of water soluble sulfonamides incorporating a 4-sulfamoylphenylmethylthiourea scaffold, with potent intraocular pressure lowering properties.
Journal of enzyme inhibition and medicinal chemistry 2002;17(5):333-43.
2002: Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs.
Environmental health perspectives 2002;110 Suppl 5():801-6.
2002: Maestrelli Francesca; Mura Paola; Casini Angela; Mincione Francesco; Scozzafava Andrea; Supuran Claudiu T
Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents.
Journal of pharmaceutical sciences 2002;91(10):2211-9.
2002: Scozzafava Andrea; Supuran Claudiu T
Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.
Bioorganic & medicinal chemistry letters 2002;12(19):2667-72.
2002: Nielsen Carsten Uhd; Supuran Claudiu T; Scozzafava Andrea; Frokjaer Sven; Steffansen Bente; Brodin Birger
Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line.
Pharmaceutical research 2002;19(9):1337-44.
2002: Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties.
Journal of enzyme inhibition and medicinal chemistry 2002;17(4):261-6.
2002: Abbate Francesco; Supuran Claudiu T; Scozzafava Andrea; Orioli Pierluigi; Stubbs Milton T; Klebe Gerhard
Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.
Journal of medicinal chemistry 2002;45(17):3583-7.
2002: Supuran Claudiu T; Scozzafava Andrea; Clare Brian W
Bacterial protease inhibitors.
Medicinal research reviews 2002;22(4):329-72.
2002: Scozzafava Andrea; Casini Angela; Supuran Claudiu T
Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs.
Current medicinal chemistry 2002;9(12):1167-85.
2002: Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.
Bioorganic & medicinal chemistry letters 2002;12(12):1551-7.
2002: Ferraroni Marta; Ruiz Tarifa Maria Yolanda; Briganti Fabrizio; Scozzafava Andrea; Mangani Stefano; Solyanikova Inna P; Kolomytseva Marina P; Golovleva Ludmilla
4-Chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: crystallization and preliminary crystallographic analysis.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1074-6.
2002: Ferraroni Marta; Tilli Silvia; Briganti Fabrizio; Chegwidden W Richard; Supuran Claudiu T; Wiebauer Karin E; Tashian Richard E; Scozzafava Andrea
Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.
Biochemistry 2002;41(20):6237-44.
2002: Chohan Zahid H; Pervez Humayun; Rauf Abdul; Scozzafava Andrea; Supuran Claudiu T
Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):117-22.
2002: Chohan Zahid H; Rau Abdul; Noreen Sobia; Scozzafava Andrea; Supuran Claudiu T
Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):101-6.
2002: Chohan Zahid H; Iqbal Mohammad S; Iqbal Hummara Sadia; Scozzafava Andrea; Supuran Claudiu T
Transition metal acetylsalicylates and their anti-inflammatory activity.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):87-91.
2002: Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):69-76.
2002: Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.
Bioorganic & medicinal chemistry letters 2002;12(8):1177-80.
2002: Casini Angela; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Laudiu T
Sulfonamides and sulfonylated derivatives as anticancer agents.
Current cancer drug targets 2002;2(1):55-75.
2002: Scozzafava Andrea; Menabuoni Luca; Mincione Francesco; Supuran Claudiu T
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Journal of medicinal chemistry 2002;45(7):1466-76.
2002: Casini Angela; Mincione Francesco; Vullo Daniela; Menabuoni Luca; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold.
Journal of enzyme inhibition and medicinal chemistry 2002;17(1):9-18.
2002: Chohan Zahid H; Farooq M A; Scozzafava Andrea; Supuran Claudiu T
Antibacterial Schiff bases of oxalyl-hydrazine/diamide incorporating pyrrolyl and salicylyl moieties and of their zinc(II) complexes.
Journal of enzyme inhibition and medicinal chemistry 2002;17(1):1-7.
2002: Ilies Monica; Banciu Mircea D; Ilies Marc A; Scozzafava Andrea; Caproiu Miron T; Supuran Claudiu T
Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.
Journal of medicinal chemistry 2002;45(2):504-10.
2002: Masereel Bernard; Rolin Stéphanie; Abbate Francesco; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
Journal of medicinal chemistry 2002;45(2):312-20.
2002: Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.
Journal of medicinal chemistry 2002;45(2):284-91.
2001: Ul-Hassan M; Scozzafava A; Chohan Z H; Supuran C T
Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 2001;16(6):499-505.
2001: Scozzafava A; Mastrolorenzo A; Supuran C T
Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives.
Journal of enzyme inhibition 2001;16(5):425-32.
2001: Scozzafava A; Saramet I; Banciu M D; Supuran C T
Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.
Journal of enzyme inhibition 2001;16(4):351-8.
2001: Randazzo D; Berti D; Briganti F; Baglioni P; Scozzafava A; Di Gennaro P; Galli E; Bestetti G
Efficient polycyclic aromatic hydrocarbons dihydroxylation in direct micellar systems.
Biotechnology and bioengineering 2001;74(3):240-8.
2001: Mincione F; Starnotti M; Menabuoni L; Scozzafava A; Casini A; Supuran C T
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.
Bioorganic & medicinal chemistry letters 2001;11(13):1787-91.
2001: Scozzafava A; Mastrolorenzo A; Supuran C T
Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.
Bioorganic & medicinal chemistry letters 2001;11(13):1675-8.
2001: Supuran C T; Briganti F; Tilli S; Chegwidden W R; Scozzafava A
Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?
Bioorganic & medicinal chemistry 2001;9(3):703-14.
2001: Scozzafava A; Menabuoni L; Mincione F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
Bioorganic & medicinal chemistry letters 2001;11(4):575-82.
2001: Scozzafava A; Mastrolorenzo A; Supuran C T
Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin?
Journal of enzyme inhibition 2001;16(1):55-63.
2001: Scozzafava A; Mincione F; Menabuoni L; Supuran C T
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating phthaloyl and phthalimido moieties.
Drug design and discovery 2001;17(4):337-48.
2001: Casini A; Mincione F; Ilies M A; Menabuoni L; Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties.
Journal of enzyme inhibition 2001;16(2):113-23.
2000: Casini A; Scozzafava A; Mincione F; Menabuoni L; Ilies M A; Supuran C T
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Journal of medicinal chemistry 2000;43(25):4884-92.
2000: Briganti F; Pessione E; Giunta C; Mazzoli R; Scozzafava A
Purification and catalytic properties of two catechol 1,2-dioxygenase isozymes from benzoate-grown cells of Acinetobacter radioresistens.
Journal of protein chemistry 2000;19(8):709-16.
2000: Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Journal of medicinal chemistry 2000;43(23):4542-51.
2000: Scozzafava A; Supuran C T
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Journal of medicinal chemistry 2000;43(20):3677-87.
2000: Guerri A; Briganti F; Scozzafava A; Supuran C T; Mangani S
Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.
Biochemistry 2000;39(40):12391-7.
2000: Ilies M; Supuran C T; Scozzafava A; Casini A; Mincione F; Menabuoni L; Caproiu M T; Maganu M; Banciu M D
Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions.
Bioorganic & medicinal chemistry 2000;8(8):2145-55.
2000: Scozzafava A; Mastrolorenzo A; Supuran C T
Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents.
Bioorganic & medicinal chemistry letters 2000;10(16):1887-91.
2000: Scozzafava A; Ilies M A; Manole G; Supuran C T
Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-beta-alanine hydroxamate moieties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11(1):69-79.
2000: Scozzafava A; Supuran C T
Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Journal of medicinal chemistry 2000;43(9):1858-65.
2000: Supuran C T; Scozzafava A; Briganti F; Clare B W
Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.
Journal of medicinal chemistry 2000;43(9):1793-806.
2000: Bencini A; Bill E; Mariotti F; Totti F; Scozzafava A; Vargas A
Density functional description of the early stages of the dioxygenation of [(MeC(CH2PPh2)3)M(catecholate)]+ complexes [M = Co(III), Ir(III)]: toward a rationalization of the catalytic mechanism of ring-opening dioxygenases.
Inorganic chemistry 2000;39(7):1418-25.
2000: Berti D; Randazzo D; Briganti F; Baglioni P; Scozzafava A; Di Gennaro P; Galli E; Bestetti G
Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production.
Journal of inorganic biochemistry 2000;79(1-4):103-8.
2000: Supuran C T; Briganti F; Menabuoni L; Mincione G; Mincione F; Scozzafava A
Carbonic anhydrase inhibitors - part 78(#). Synthesis of water-soluble sulfonamides incorporating beta-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route.
European journal of medicinal chemistry 2000;35(3):309-21.
2000: Scozzafava A; Supuran C T
Protease inhibitors - part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase.
European journal of medicinal chemistry 2000;35(3):299-307.
2000: Scozzafava A; Supuran C T
Protease inhibitors: synthesis of clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties.
Bioorganic & medicinal chemistry letters 2000;10(5):499-502.
2000: Scozzafava A; Supuran C T
Protease inhibitors. Part 8: synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties.
Bioorganic & medicinal chemistry 2000;8(3):637-45.
2000: Supuran C T; Scozzafava A
Protease inhibitors. Part 7. Inhibition of Clostridium histolyticum collagenase with sulfonylated derivatives of L-valine hydroxamate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(1):67-76.
2000: Scozzafava A; Supuran C T
Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(1):29-41.
2000: Scozzafava A; Supuran C T
Carbonic anhydrase activators - part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties.
European journal of medicinal chemistry 2000;35(1):31-9.
2000: Scozzafava A; Briganti F; Ilies M A; Supuran C T
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Journal of medicinal chemistry 2000;43(2):292-300.
2000: Ilies M A; Supuran C T; Scozzafava A
Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances.
Metal-based drugs 2000;7(2):57-62.
2000: Supuran C T; Scozzafava A
Activation of carbonic anhydrase isozymes.
EXS 2000;(90):197-219.
2000: Supuran C T; Scozzafava A
Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors.
Journal of enzyme inhibition 2000;15(6):597-610.
2000: Scozzafava A; Banciu M D; Popescu A; Supuran C T
Carbonic anhydrase inhibitors: synthesis of Schiff bases of hydroxybenzaldehydes with aromatic sulfonamides and their reactions with arylsulfonyl isocyanates.
Journal of enzyme inhibition 2000;15(6):533-46.
2000: Supuran C T; Scozzafava A
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole.
Journal of enzyme inhibition 2000;15(5):471-86.
2000: Scozzafava A; Banciu M D; Popescu A; Supuran C T
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives.
Journal of enzyme inhibition 2000;15(5):443-53.
2000: Supuran C T; Scozzafava A; Ilies M A; Briganti F
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes.
Journal of enzyme inhibition 2000;15(4):381-401.
2000: Supuran C T; Briganti F; Scozzafava A; Ilies M A
Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.
Journal of enzyme inhibition 2000;15(4):335-56.
2000: Scozzafava A; Iorga B; Supuran C T
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives).
Journal of enzyme inhibition 2000;15(2):139-61.
2000: Supuran C T; Briganti F; Mincione G; Scozzafava A
Protease inhibitors: Synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of clostridium histolyticum collagenase.
Journal of enzyme inhibition 2000;15(2):111-28.
2000: Barboiu M; Supuran C T; Menabuoni L; Scozzafava A; Mincione F; Briganti F; Mincione G
Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide.
Journal of enzyme inhibition 2000;15(1):23-46.
2000: Clare B W; Scozzafava A; Briganti F; Iorga B; Supuran C T
Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations.
Journal of enzyme inhibition 2000;15(3):235-64.
1999: Supuran C T; Scozzafava A
Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators.
Bioorganic & medicinal chemistry 1999;7(12):2915-23.
1999: Mincione G; Menabuoni L; Briganti F; Mincione F; Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors. Part 79. Synthesis of topically acting sulfonamides incorporating GABA moieties in their molecule, with long-lasting intraocular pressure-lowering properties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;9(2):185-99.
1999: Borras J; Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties: is the tail more important than the ring?
Bioorganic & medicinal chemistry 1999;7(11):2397-406.
1999: Scozzafava A; Briganti F; Mincione G; Menabuoni L; Mincione F; Supuran C T
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Journal of medicinal chemistry 1999;42(18):3690-700.
1999: Supuran C T; Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G
Carbonic anhydrase inhibitors. Part 71. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering sulfonamides incorporating picolinoyl moieties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;8(4):317-28.
1999: Supuran C T; Scozzafava A; Mincione F; Menabuoni L; Briganti F; Mincione G; Jitianu M
Carbonic anhydrase inhibitors. Part 60(#). The topical intraocular pressure-lowering properties of metal complexes of a heterocyclic sulfonamide: influence of the metal ion upon biological activity.
European journal of medicinal chemistry 1999;34(7-8):585-95.
1999: Briganti F; Scozzafava A; Supuran C T
Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties.
Bioorganic & medicinal chemistry letters 1999;9(14):2043-8.
1999: Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Journal of medicinal chemistry 1999;42(14):2641-50.
1999: Benvenuti M; Briganti F; Scozzafava A; Golovleva L; Travkin V M; Mangani S
Crystallization and preliminary crystallographic analysis of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E: a novel dioxygenase involved in the biodegradation of polychlorinated aromatic compounds.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 4):901-3.
1999: Menabuoni L; Scozzafava A; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors. Water-soluble, topically effective intraocular pressure lowering agents derived from isonicotinic acid and aromatic/heterocyclic sulfonamides: is the tail more important than the ring?
Journal of enzyme inhibition 1999;14(6):457-74.
1999: Popescu A; Simion A; Scozzafava A; Briganti F; Supuran C T
Carbonic anhydrase inhibitors. Schiff bases of some aromatic sulfonamides and their metal complexes: towards more selective inhibitors of carbonic anhydrase isozyme IV.
Journal of enzyme inhibition 1999;14(6):407-23.
1999: Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors. Arylsulfonylureido- and arylureido-substituted aromatic and heterocyclic sulfonamides: towards selective inhibitors of carbonic anhydrase isozyme I.
Journal of enzyme inhibition 1999;14(5):343-63.
1999: Supuran C T; Scozzafava A; Briganti F
Carbonic anhydrase inhibitors: N-cyanosulfonamides, a new class of high affinity isozyme II and IV inhibitors.
Journal of enzyme inhibition 1999;14(4):289-306.
1998: Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: novel compounds containing S-NH moieties: sulfenamido-sulfonamides, sulfenimido-sulfonamides and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 1998;13(6):419-42.
1998: Briganti F; Mangani S; Pedocchi L; Scozzafava A; Golovleva L A; Jadan A P; Solyanikova I P
XAS characterization of the active sites of novel intradiol ring-cleaving dioxygenases: hydroxyquinol and chlorocatechol dioxygenases.
FEBS letters 1998;433(1-2):58-62.
1998: Supuran C T; Scozzafava A; Briganti F; Loloiu G; Maior O
Sulfonylamido derivatives of 2-aminophenoxathiin-10,10-dioxide and related compounds possess antifungal action due to the possible inhibition of lanosterol-14-alpha-demethylase.
Journal of enzyme inhibition 1998;13(4):291-310.
1998: Mincione F; Menabuoni L; Briganti F; Mincione G; Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents.
Journal of enzyme inhibition 1998;13(4):267-84.
1998: Supuran C T; Scozzafava A; Saramet I; Banciu M D
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with heterocyclic mercaptans, sulfenamides, sulfonamides and their metal complexes.
Journal of enzyme inhibition 1998;13(3):177-94.
1998: Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 1998;13(2):103-23.
1998: Scozzafava A; Nicolae A; Maior O; Briganti F; Supuran C T
The antifungal activity of 2,2'-diamino-4,4'-dithiazole derivatives is due to the possible inhibition of lanosterol-14-alpha-demethylase.
Journal of enzyme inhibition 1998;14(1):49-68.
1997: Briganti F; Pessione E; Giunta C; Scozzafava A
Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens.
FEBS letters 1997;416(1):61-4.
1997: Supuran C T; Briganti F; Scozzafava A
Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV.
Journal of enzyme inhibition 1997;12(3):175-90.
1997: Briganti F; Mangani S; Orioli P; Scozzafava A; Vernaglione G; Supuran C T
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.
Biochemistry 1997;36(34):10384-92.
1997: Supuran C T; Scozzafava A
Novel aromatic/heterocyclic sulfonamides and their metal complexes as inhibitors of carbonic anhydrase isozymes I, II and IV.
Journal of enzyme inhibition 1997;12(1):37-51.
1997: Travkin V M; Jadan A P; Briganti F; Scozzafava A; Golovleva L A
Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T.
FEBS letters 1997;407(1):69-72.
1996: Borràs J; Casanova J; Cristea T; Gheorghe A; Scozzafava A; Supuran C T; Tudor V
Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase.
Metal-based drugs 1996;3(3):143-8.
1994: Bertini I; Briganti F; Mangani S; Nolting H F; Scozzafava A
X-ray absorption studies on catechol 2,3-dioxygenase from Pseudomonas putida mt2.
Biochemistry 1994;33(35):10777-84.
1994: Bertini I; Briganti F; Mangani S; Nolting H F; Scozzafava A
Substrate, substrate analogue, and inhibitor interactions with the ferrous active site of catechol 2,3-dioxygenase monitored through XAS studies.
FEBS letters 1994;350(2-3):207-12.
1994: Bertini I; Briganti F; Scozzafava A
Aliphatic and aromatic inhibitors binding to the active site of catechol 2,3-dioxygenase from Pseudomonas putida mt-2.
FEBS letters 1994;343(1):56-60.
1994: Mangani S; Orioli P L; Scozzafava A; Messori L; Carloni P
EXAFS studies of Fe(III)-phosvitin at high metal to protein ratios.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1994;7(2):104-8.
1993: Bertini I; Briganti F; Calzolai L; Messori L; Scozzafava A
Selective interaction of ferricyanide with cluster I of Clostridium pasteurianum 2[Fe4S4] ferredoxin.
FEBS letters 1993;332(3):268-72.
1993: Scozzafava A; Viezzoli M S
The role of the active site amino acid residues on the catalytic activity of Cu2Zn2SOD.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1993;19(1-2):193-204.
1992: Bertini I; Briganti F; Luchinat C; Messori L; Monnanni R; Scozzafava A; Vallini G
1H-NMR studies on partially and fully reduced 2(4Fe-4S) ferredoxin from Clostridium pasteurianum.
European journal of biochemistry / FEBS 1992;204(2):831-9.
1991: Bertini I; Briganti F; Luchinat C; Messori L; Monnanni R; Scozzafava A; Vallini G
2D 1H NMR studies of oxidized 2(Fe4S4) ferredoxin from Clostridium pasteurianum.
FEBS letters 1991;289(2):253-6.
1990: Bal W; Bertini I; Kozlowski H; Monnanni R; Scozzafava A; Siatecki G Z
The unusual behavior of the inhibitor S(+)(1-amino-2-phenylethyl)phosphonic acid towards carboxypeptidase A.
Journal of inorganic biochemistry 1990;40(3):227-35.
1990: Bertini I; Briganti F; Monnanni R; Scozzafava A; Carlozzi P; Materassi R
1H NMR studies of Chromatium vinosum cytochrome c'.
Archives of biochemistry and biophysics 1990;282(1):84-90.
1989: Banci L; Bertini I; Luchinat C; Scozzafava A
Cyanide and azide behave in a similar fashion versus cuprozinc-superoxide dismutase.
The Journal of biological chemistry 1989;264(17):9742-4.
1986: Bertini I; Luchinat C; Messori L; Monnanni R; Scozzafava A
The metal-binding properties of ovotransferrin. An investigation of cobalt(II) derivatives.
The Journal of biological chemistry 1986;261(3):1139-46.
1984: Bertini I; Luchinat C; Messori L; Scozzafava A
Cobalt(II) as an NMR probe for the investigation of the coordination sites of conalbumin.
European journal of biochemistry / FEBS 1984;141(2):375-8.
1982: Bertini I; Luchinat C; Monnanni R; Scozzafava A
Different behavior of sulfonamides with respect to copper-substituted bovine and human carbonic anhydrases.
Journal of inorganic biochemistry 1982;16(2):155-60.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Andrea Scozzafava

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Procedures

Occupations

Anatomy

Disorders

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Andrea Scozzafava (preview)

All Publications