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Dominic Scudiero

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Susan D Mertins; Anne Monks; David S Salomon; Dominic A Scudiero; Michael C Alley; David G Covell; Raymond D Divelbiss; Karen Hite; Melinda G Hollingshead; John E Niederhuber
A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
Paul Klausmeyer; Thomas G McCloud; Dominic A Scudiero; John H Cardellina Ii; Michael J Currens; Robert H Shoemaker
Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα.
Vaibhav Saini; Dominic A Scudiero; Jalpa Shah; Thomas E Silvers; Mark W Burkett; Rene M Delosh; Bingnan Han; Karen Hite; Melinda G Hollingshead; Curtis Hose; Angelena Millione; Anne Monks; Kunio Nagashima; Dianne L Newton; Robert H Shoemaker
Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.

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All Publications

2013: Susan D Mertins; Anne Monks; David S Salomon; Dominic A Scudiero; Michael C Alley; David G Covell; Raymond D Divelbiss; Karen Hite; Melinda G Hollingshead; John E Niederhuber
A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
PloS one 2013;8(2):e57099.
2012: Paul Klausmeyer; Thomas G McCloud; Dominic A Scudiero; John H Cardellina Ii; Michael J Currens; Robert H Shoemaker
Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα.
Bioorganic & medicinal chemistry 2012;20(15):4646-52.
2012: Vaibhav Saini; Dominic A Scudiero; Jalpa Shah; Thomas E Silvers; Mark W Burkett; Rene M Delosh; Bingnan Han; Karen Hite; Melinda G Hollingshead; Curtis Hose; Angelena Millione; Anne Monks; Kunio Nagashima; Dianne L Newton; Robert H Shoemaker
Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.
PloS one 2012;7(8):e41401.
2010: Sarah L Heyerdahl; Julian Rozenberg; Louis Jamtgaard; Vikas Rishi; Lyuba Varticovski; Kelly Akah; Dominic A Scudiero; Robert H Shoemaker; Tatiana S Karpova; Richard N Day; James G McNally; Charles Vinson
The arylstibonic acid compound NSC13746 disrupts B-ZIP binding to DNA in living cells.
European journal of cell biology 2010;89(7):564-73.
2010: Vikas Rishi; Won-Jun Oh; Sarah L Heyerdahl; Jianfei Zhao; Dominic A Scudiero; Robert H Shoemaker; Charles Vinson
12 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers.
Journal of structural biology 2010;170(2):216-25.
2009: Paul Klausmeyer; Qin Zhou; Dominic A Scudiero; Badarch Uranchimeg; Giovanni Melillo; John H Cardellina; Robert H Shoemaker; Ching-Jer Chang; Thomas G McCloud
Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.
Journal of natural products 2009;72(5):805-12.
2009: Tamara L Meragelman; Dominic A Scudiero; R Eric Davis; Louis M Staudt; Thomas G McCloud; John H Cardellina; Robert H Shoemaker
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
Journal of natural products 2009;72(3):336-9.
2008: Paul Klausmeyer; Thomas G McCloud; Badarch Uranchimeg; Giovanni Melillo; Dominic A Scudiero; John H Cardellina; Robert H Shoemaker
Separation and SAR study of HIF-1alpha inhibitory tubulosines from Alangium cf. longiflorum.
Planta medica 2008;74(3):258-63.
2008: Sally A Amundson; Khanh T Do; Lisa C Vinikoor; R Anthony Lee; Christine A Koch-Paiz; Jaeyong Ahn; Mark Reimers; Yidong Chen; Dominic A Scudiero; John N Weinstein; Jeffrey M. Trent; Michael Bittner; Paul S Meltzer; Albert J Fornace
Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen.
Cancer research 2008;68(2):415-24.
2007: Andrew G Jobson; John H Cardellina; Dominic A Scudiero; Sudhir B Kondapaka; Hongliang Zhang; Hijoo Kim; Robert Shoemaker; Yves Pommier
Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.
Molecular pharmacology 2007;72(4):876-84.
2007: L Li; Linda Yang; Dominic A Scudiero; S A Miller; Z-X Yu; P Todd Stukenberg; Robert H Shoemaker; robert kotin
Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells.
Gene therapy 2007;14(10):814-27.
2007: Uma Shankavaram; William C Reinhold; Satoshi Nishizuka; Sylvia M Major; Daisaku Morita; Krishna K Chary; Mark Reimers; Uwe Scherf; Ari Kahn; Douglas Dolginow; Jeffrey Cossman; Eric P Kaldjian; Dominic A Scudiero; Emanuel F Petricoin; Lance A Liotta; Jae K Lee; John N Weinstein
Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study.
Molecular cancer therapeutics 2007;6(3):820-32.
2007: William C Reinhold; Mark Reimers; Alika K Maunakea; Sohyoung Kim; Samir Lababidi; Uwe Scherf; Uma Shankavaram; Micah S Ziegler; Claudia Stewart; Hosein Kouros-Mehr; Hengmi Cui; Douglas Dolginow; Dominic A Scudiero; Yves Pommier; David J Munroe; Andrew P Feinberg; John N Weinstein
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.
Molecular cancer therapeutics 2007;6(2):391-403.
2007: Paul Klausmeyer; Thomas G McCloud; Giovanni Melillo; Dominic A Scudiero; John H Cardellina; Robert H Shoemaker
Identification of a new natural camptothecin analogue in targeted screening for HIF-1alpha inhibitors.
Planta medica 2007;73(1):49-52.
2006: Tam L Nguyen; Rick Gussio; jeffrey smith; Deborah A Lannigan; Sidney Hecht; Dominic A Scudiero; Robert H Shoemaker; Daniel W Zaharevitz
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
Bioorganic & medicinal chemistry 2006;14(17):6097-105.
2006: Kimberly J Bussey; Koei Chin; Samir Lababidi; Mark Reimers; William C Reinhold; Wen-Lin Kuo; Fuad G Gwadry; Hosein Kouros-Mehr; Jane Fridlyand; Ajay Jain; Colin Collins; Satoshi Nishizuka; Giovanni Tonon; Anna V Roschke; Kristen S Gehlhaus; Ilan Kirsch; Dominic A Scudiero; Joe Gray; John N Weinstein
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.
Molecular cancer therapeutics 2006;5(4):853-67.
2006: Mikhail G Kolonin; Laura Bover; Jessica Sun; Amado J Zurita; Kim-Anh Do; Johanna Lahdenranta; Marina Cardó-Vila; Ricardo Giordano; Diana E Jaalouk; Michael G Ozawa; Catherine A Moya; Glauco R Souza; Fernanda I Staquicini; Akihiko Kunyiasu; Dominic A Scudiero; Susan Holbeck; Edward A Sausville; Wadih Arap; Renata Pasqualini
Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.
Cancer research 2006;66(1):34-40.
2005: Lars H Jensen; Annemette Vinding Thougaard; Morten Grauslund; Birgitte Søkilde; Elisabeth V Carstensen; Henrik K Dvinge; Dominic A Scudiero; Peter B Jensen; Robert H Shoemaker; Maxwell Sehested
Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
Cancer research 2005;65(16):7470-7.
2005: Vikas Rishi; Timothy Potter; Julie Laudeman; Russel Reinhart; Thomas Silvers; Michael Selby; Timothy Stevenson; Paula Krosky; Andrew G Stephen; Asha Acharya; Jon Moll; Won-Jun Oh; Dominic A Scudiero; Robert H Shoemaker; Charles Vinson
A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors.
Analytical biochemistry 2005;340(2):259-71.
2004: Phyllis A Svingen; David Loegering; Joe Rodriquez; Xue Wei Meng; Peter W Mesner; Susan Holbeck; Anne Monks; Stan Krajewski; Dominic A Scudiero; Edward A Sausville; John C Reed; Yuri A Lazebnik; Scott H Kaufmann
Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6807-20.
2004: Aaron D Schimmer; Kate Welsh; Clemencia Pinilla; Zhiliang Wang; Maryla Krajewska; Marie-Josee Bonneau; Irene M Pedersen; Shinichi Kitada; Fiona L Scott; Beatrice Bailly-Maitre; Gennadi V Glinsky; Dominic A Scudiero; Edward A Sausville; Guy S Salvesen; Adel Nefzi; John M Ostresh; Richard A Houghten; John C Reed
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer cell 2004;5(1):25-35.
2003: Anna V Roschke; Giovanni Tonon; Kristen S Gehlhaus; Nicolas McTyre; Kimberly J Bussey; Samir Lababidi; Dominic A Scudiero; John N Weinstein; Ilan R Kirsch
Karyotypic complexity of the NCI-60 drug-screening panel.
Cancer research 2003;63(24):8634-47.
2003: Giovanni Di Pasquale; Beverly L Davidson; Colleen S Stein; Inês Martins; Dominic A Scudiero; Anne Monks; John A Chiorini
Identification of PDGFR as a receptor for AAV-5 transduction.
Nature medicine 2003;9(10):1306-12.
2003: Constance J Glover; Karen Hite; Renee DeLosh; Dominic A Scudiero; Matthew J Fivash; Lindsey R Smith; Robert J Fisher; Jia Wei Wu; Yigong Shi; Rachael A Kipp; George L McLendon; Edward A Sausville; Robert H Shoemaker
A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.
Analytical biochemistry 2003;320(2):157-69.
2003: Satoshi Nishizuka; Sing-Tsung Chen; Fuad G Gwadry; Jes Alexander; Sylvia M Major; Uwe Scherf; William C Reinhold; Mark Waltham; Lu Charboneau; Lynn Young; Kimberly J Bussey; Sohyoung Kim; Samir Lababidi; Jae K Lee; Stefania Pittaluga; Dominic A Scudiero; Edward A Sausville; Peter J Munson; Emanuel F Petricoin; Lance A Liotta; Stephen M Hewitt; Mark Raffeld; John N Weinstein
Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling.
Cancer research 2003;63(17):5243-50.
2002: Annamaria Rapisarda; Badarch Uranchimeg; Dominic A Scudiero; Mike Selby; Edward A Sausville; Robert H Shoemaker; Giovanni Melillo
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
Cancer research 2002;62(15):4316-24.
2002: Zhiyuan Xu; Zhong-Ping Chen; Areti Malapetsa; Moulay A Alaoui-Jamali; Josée Bergeron; Anne Monks; Timothy G Myers; Gérard Mohr; Edward A Sausville; Dominic A Scudiero; Raquel Aloyz; Lawrence Panasci
DNA repair protein levels vis-à-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program.
Anti-cancer drugs 2002;13(5):511-9.
2002: Zhong-Ping Chen; Areti Malapetsa; Anne Monks; Timothy G Myers; Gérard Mohr; Edward A Sausville; Dominic A Scudiero; Lawrence Panasci
Nucleotide excision repair protein levels vis-à-vis anticancer drug resistance in 60 human tumor cell lines.
Ai zheng = Aizheng = Chinese journal of cancer 2002;21(3):233-9.
2002: Robert H Shoemaker; Dominic A Scudiero; Giovanni Melillo; Michael J Currens; Anne P Monks; Alfred A Rabow; David G Covell; Edward A Sausville
Application of high-throughput, molecular-targeted screening to anticancer drug discovery.
Current topics in medicinal chemistry 2002;2(3):229-46.
2001: Ivo Meinhold-Heerlein; Frank Stenner-Liewen; Heike Liewen; Shinichi Kitada; Maryla Krajewska; Stan Krajewski; Juan M Zapata; Anne Monks; Dominic A Scudiero; Thomas Bauknecht; John C Reed
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.
The American journal of pathology 2001;158(4):1335-44.
2001: LJ Yu; J Matias; Dominic A Scudiero; Karen Hite; Anne Monks; Edward A Sausville; David J Waxman
P450 enzyme expression patterns in the NCI human tumor cell line panel.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(3):304-12.
2000: Sally A Amundson; Timothy G Myers; Dominic A Scudiero; Shinichi Kitada; J C Reed; Albert J Fornace
An informatics approach identifying markers of chemosensitivity in human cancer cell lines.
Cancer research 2000;60(21):6101-10.
2000: Ingo Tamm; S M Kornblau; Harry Segall; Stan Krajewski; Kate Welsh; Shinichi Kitada; Dominic A Scudiero; G Tudor; Y H Qui; Anne Monks; Michael Andreeff; John C Reed
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1796-803.
2000: Uwe Scherf; Douglas T Ross; Mark Waltham; Lawrence H Smith; Jae K Lee; Lorraine Tanabe; Kurt W Kohn; William C Reinhold; Timothy G Myers; D T Andrews; Dominic A Scudiero; Michael B Eisen; Edward A Sausville; Yves Pommier; David Botstein; Patrick O Brown; John N Weinstein
A gene expression database for the molecular pharmacology of cancer.
Nature genetics 2000;24(3):236-44.
1998: Ingo Tamm; Y Wang; Edward A Sausville; Dominic A Scudiero; N Vigna; T Oltersdorf; John C Reed
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.
Cancer research 1998;58(23):5315-20.
1998: Shinichi Takayama; Stan Krajewski; Maryla Krajewska; Shinichi Kitada; Juan M Zapata; K Kochel; Deborah A Knee; Dominic A Scudiero; G Tudor; G J Miller; T Miyashita; M Yamada; John C Reed
Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.
Cancer research 1998;58(14):3116-31.
1998: Dominic A Scudiero; Anne Monks; Edward A Sausville
Cell line designation change: multidrug-resistant cell line in the NCI anticancer screen.
Journal of the National Cancer Institute 1998;90(11):862.
1998: Shinichi Kitada; Maryla Krajewska; X Zhang; Dominic A Scudiero; Juan M Zapata; Hong-Gang Wang; Ahmed Shabaik; G Tudor; Stan Krajewski; Timothy G Myers; G S Johnson; Edward A Sausville; John C Reed
Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.
The American journal of pathology 1998;152(1):51-61.
1997: Anne Monks; Dominic A Scudiero; G S Johnson; KD Paull; Edward A Sausville
The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets.
Anti-cancer drug design 1997;12(7):533-41.
1997: Patrick M O'Connor; J Jackman; I Bae; Timothy G Myers; S Fan; Michihiro Mutoh; Dominic A Scudiero; Anne Monks; Edward A Sausville; John N Weinstein; SH Friend; Albert J Fornace; Kurt W Kohn
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer research 1997;57(19):4285-300.
1997: Timothy G Myers; N L Anderson; Mark Waltham; Guang Li; JK Buolamwini; Dominic A Scudiero; KD Paull; Edward A Sausville; John N Weinstein
A protein expression database for the molecular pharmacology of cancer.
Electrophoresis 1997;18(3-4):647-53.
1997: J N Weinstein; Timothy G Myers; P M O'Connor; S H Friend; Albert J Fornace; K W Kohn; T Fojo; S E Bates; L V Rubinstein; N L Anderson; JK Buolamwini; W W van Osdol; Anne Monks; Dominic A Scudiero; Edward A Sausville; Daniel W Zaharevitz; B Bunow; Vellarkad Viswanadhan; G S Johnson; R E Wittes; KD Paull
An information-intensive approach to the molecular pharmacology of cancer.
Science (New York, N.Y.) 1997;275(5298):343-9.
1996: I Bae; ML Smith; MS Sheikh; Qimin Zhan; Dominic A Scudiero; S H Friend; Patrick M O'Connor; Albert J Fornace
An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.
Cancer research 1996;56(4):840-7.
1995: Wieslaw Cholody; L Hernandez; L Hassner; Dominic A Scudiero; D B Djurickovic; Christopher J Michejda
Bisimidazoacridones and related compounds: new antineoplastic agents with high selectivity against colon tumors.
Journal of medicinal chemistry 1995;38(16):3043-52.
1994: Kamran Gharehbaghi; KD Paull; James A Kelley; Joseph J Barchi; Victor E Marquez; D A Cooney; Anne Monks; Dominic A Scudiero; K Krohn; Hiremagalur N Jayaram
Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase.
International journal of cancer. Journal international du cancer 1994;56(6):892-9.
1993: Eric Solary; F Leteurtre; KD Paull; Dominic A Scudiero; E Hamel; Yves Pommier
Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.
Biochemical pharmacology 1993;45(12):2449-56.
1992: John N Weinstein; Kurt W Kohn; Michael R Grever; Vellarkad Viswanadhan; L V Rubinstein; Anne Monks; Dominic A Scudiero; L Welch; A D Koutsoukos; A J Chiausa
Neural computing in cancer drug development: predicting mechanism of action.
Science (New York, N.Y.) 1992;258(5081):447-51.
1992: L Wu; A M Smythe; S F Stinson; L A Mullendore; Anne Monks; Dominic A Scudiero; KD Paull; A D Koutsoukos; L V Rubinstein; Michael R Boyd
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening.
Cancer research 1992;52(11):3029-34.
1991: Anne Monks; Dominic A Scudiero; P Skehan; R Shoemaker; KD Paull; D Vistica; C Hose; J Langley; P Cronise; A Vaigro-Wolff
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
Journal of the National Cancer Institute 1991;83(11):757-66.
1991: D T Vistica; P Skehan; Dominic A Scudiero; Anne Monks; A Pittman; Michael R Boyd
Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production.
Cancer research 1991;51(10):2515-20.
1990: R H Smith; Dominic A Scudiero; Christopher J Michejda
1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents.
Journal of medicinal chemistry 1990;33(9):2579-83.
1990: L V Rubinstein; Robert H Shoemaker; KD Paull; R M Simon; S Tosini; P Skehan; Dominic A Scudiero; Anne Monks; Michael R Boyd
Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.
Journal of the National Cancer Institute 1990;82(13):1113-8.
1990: P Skehan; R Storeng; Dominic A Scudiero; Anne Monks; J McMahon; D Vistica; J T Warren; H Bokesch; S Kenney; Michael R Boyd
New colorimetric cytotoxicity assay for anticancer-drug screening.
Journal of the National Cancer Institute 1990;82(13):1107-12.
1990: D T Vistica; Dominic A Scudiero; P Skehan; Anne Monks; Michael R Boyd
New carbon dioxide-independent basal growth medium for culture of diverse tumor and nontumor cells of human and nonhuman origin.
Journal of the National Cancer Institute 1990;82(12):1055-61.
1989: KD Paull; Robert H Shoemaker; L Hodes; Anne Monks; Dominic A Scudiero; Lawrence V Rubinstein; J Plowman; Michael R Boyd
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.
Journal of the National Cancer Institute 1989;81(14):1088-92.
1988: Dominic A Scudiero; Robert H Shoemaker; KD Paull; Anne Monks; S Tierney; T H Nofziger; M J Currens; D Seniff; Michael R Boyd
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.
Cancer research 1988;48(17):4827-33.
1988: M C Alley; Dominic A Scudiero; Anne Monks; M L Hursey; M J Czerwinski; D L Fine; B J Abbott; J G Mayo; Robert H Shoemaker; Michael R Boyd
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer research 1988;48(3):589-601.
1988: Robert H Shoemaker; Anne Monks; M C Alley; Dominic A Scudiero; D L Fine; T L McLemore; B J Abbott; KD Paull; J G Mayo; Michael R Boyd
Development of human tumor cell line panels for use in disease-oriented drug screening.
Progress in clinical and biological research 1988;276():265-86.